USBiological 4 - Products
Worldwide
Our biochemicals, antibodies, recombinant proteins, cell culture media and molecular biology kits are used in virtually all scientific applications.From affordable research quantities to larger bulk amounts.
| Product | Description | |
|---|---|---|
| Dextran 2000 (MW~2,000,000) | Dextran 2000 (MW~2000000) is a complex glucan that is used during surgery to prevent deep venous thrombosis and post-operative thrombosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 9004-54-0. Pack Sizes: 5g, 10g. Molecular Formula: N/A, Molecular Weight: 2000000. US Biological Life Sciences. |  Worldwide |
| Dextran 40(Mw.=ca. 40000) | Dextran 40(Mw.=ca. 40000). Group: Molecular Biology. CAS No. 9004-54-0. Pack Sizes: 25g, 100g. US Biological Life Sciences. | Worldwide |
| D-γ-Tocotrienol | γ-Tocotrienol exhibits antioxidant properties and belongs to the vitamin E family. It is naturally found in wheat germ oil and bran. In addition, α-tocopherol and γ-tocotrienol derivatives are potential lead compounds for developing anticancer and antiproliferative agents against MCF-7 and MDA-MB-231 breast cancer cells and the A549 lung cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 14101-61-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H42O2. US Biological Life Sciences. | Worldwide |
| D-Gluconic Acid Aluminum Complex | D-Gluconic Acid Aluminum Complex is an effective antacid. Group: Biochemicals. Grades: Highly Purified. CAS No. 13755-41-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C6H13AlO9; (C4H11NO3), Molecular Weight: 256.141211399999. US Biological Life Sciences. | Worldwide |
| Di(α-tocopherol) Phosphate | Di(α-tocopherol) Phosphate is used as a vitamin E supplement. Group: Biochemicals. Grades: Highly Purified. CAS No. 311313-37-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C58H99O6P. US Biological Life Sciences. | Worldwide |
| Diastovaricin I (30-Hydroxy-naphthomycin C) | Antibiotic. Antibacterial. Inducer of Friend mouse erythroleukemia cells. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 102281-52-7. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Dibenzo[b,def]chrysene | Dibenzo[b,def]chrysene is a carcinogenic, polycyclic aromatic hydrocarbon whose derivatives have the ability to deliver high-power-conversion efficiencies in bulk heterojunction solar cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 189-64-0. Pack Sizes: 10mg, 100mg. Molecular Formula: C24H14. US Biological Life Sciences. | Worldwide |
| Dibenzylamine-d10 | Dibenzylamine-d10 is the isotope labelled analog of Dibenzylamine (D417505); a chemical contaminant in L-(+)- β-hydroxybutyrate that exhibits direct anticonvulsant actions in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 923282-09-1. Pack Sizes: 25mg, 250mg. Molecular Formula: C14H5D10N, Molecular Weight: 207.34. US Biological Life Sciences. | Worldwide |
| Dichloromethane. (Methylene Chloride) | Methylene Chloride is a solvent used in the synthesis and polymerization of bicyclic ketals, which are class of materials for drug delivery to sensitive tissues. Group: Biochemicals. Grades: Highly Purified. CAS No. 75-09-2. Pack Sizes: 50mL, 100mL. Molecular Formula: CH2Cl2. US Biological Life Sciences. | Worldwide |
| Didodecyl 3,3'-Thiodipropionate | Didodecyl 3,3'-Thiodipropionate is an antioxidant used as a modifier to stabilize acrylonitrile-?butadiene-?styrene (ABS) graft copolymers due to a strong synergistic effect. Group: Biochemicals. Grades: Highly Purified. CAS No. 123-28-4. Pack Sizes: 10g, 50g. Molecular Formula: C30H58O4S. US Biological Life Sciences. | Worldwide |
| Diethylene Glycol Monolaurate | Diethylene Glycol Monolaurate is a non-ionic surfactant that can be used as an emulsifier. It is a potent nonionic detergent. Group: Biochemicals. Grades: Highly Purified. CAS No. 141-20-8. Pack Sizes: 1g, 5g. Molecular Formula: C16H32O4. US Biological Life Sciences. | Worldwide |
| Diethyl Malonate-d2 | Diethyl Malonate-d2 is the isotope labelled analog of Diethyl Malonate (D444420). Diethyl Malonate occurs naturally in grapes and strawberries. It is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes. Group: Biochemicals. Grades: Highly Purified. CAS No. 4303-49-5. Pack Sizes: 1g, 5g. Molecular Formula: C7H10D2O4. US Biological Life Sciences. | Worldwide |
| Differolide | Signal substance. Microbial bioregulator. Group: Biochemicals. Grades: Highly Purified. CAS No. 106750-00-9. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Dihydrochlamydocin | Phytotoxin. Derivative of HDAC inhibitor chlamydocin. Similar chemical structure to the TAN-1746 compounds (potent HDAC inhibitors). Group: Biochemicals. Grades: Highly Purified. CAS No. 59678-46-5. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| Dihydromanumycin A | Derivative of the farnesyltransferase inhibitor Manumycin A. This compound has not yet been thoroughly tested for its biological activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Dihydro Normorphine 3-O- β-D-Glucuronide | Dihydro Normorphine 3-O- β-D-Glucuronide is a glucuronide derivative of Dihydro Normorphine (D450350). Group: Biochemicals. Grades: Highly Purified. CAS No. 491847-30-4. Pack Sizes: 1mg. Molecular Formula: C22H27NO9, Molecular Weight: 449.45. US Biological Life Sciences. | Worldwide |
| Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2-fluoro-1,1-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785) | A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 96201-88-6. Pack Sizes: 10mg. Molecular Formula: C??H??F?NNaO?, Primary Target: DHODH. US Biological Life Sciences. | Worldwide |
| Diisobutyl Phosphate-d14 | Diisobutyl Phosphate-d14 is the isotope labelled analog of Diisobutyl Phosphate (D455480); an analyte found in human urine and municipal wastewaters. Also an intermediate in the microbial degradation of trialkyl phosphates which are used as flame retardants and plasticizers. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C8H5D14O4P. US Biological Life Sciences. | Worldwide |
| Dillapiol | Dillapiol is an organic compound and essential oil commonly extracted from dill weed, though it can be found in a variety of other plants such as fennel root. Group: Biochemicals. Grades: Highly Purified. CAS No. 484-31-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C12H14O4, Molecular Weight: 222.24. US Biological Life Sciences. | Worldwide |
| Dimethicone Deuterated; | Dimethicone Deuterated is an isotope labelled compound of Dimethicone (D460940) which is a silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: (CD3OSi)n, Molecular Weight: -62.14. US Biological Life Sciences. | Worldwide |
| Dimethyl Adipate | Dimethyl Adipate is used as a chemical intermediate (polymers, agrochemicals), a speciality solvent (inks, coatings, adhesives), an emollient and can also be utilized as a paint remover and plasticiser. Group: Biochemicals. Grades: Highly Purified. CAS No. 627-93-0. Pack Sizes: 2.5g, 10g. Molecular Formula: C8H14O4, Molecular Weight: 174.19. US Biological Life Sciences. | Worldwide |
| Dimethylallyl Pyrophosphate Triammonium Salt | Dimethylallyl Pyrophosphate Triammonium Salt is a synthetic reagent in biochemical reactions. It is a natural occurring intermediate in biosynthetic pathways for the synthesis of natural products. Group: Biochemicals. Grades: Highly Purified. CAS No. 1186-30-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C5H21N3O7P2, Molecular Weight: 297.18. US Biological Life Sciences. | Worldwide |
| Dimethylsulfoxide (DMSO) for Cell Culture | Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets ACS testing requirements.In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90% of frozen cells will become inactive. It is particularly important in the freezing and long-term storage of embryonic stem cells and hematopoietic stem cells, which are often frozen in a mixture of 10% DMSO, a freezing medium, and 30% fetal bovine serum. In the cryogenic freezing of heteroploid cell lines (MDCK, VERO, etc.) a mixture of 10% DMSO with 90% EMEM (70% EMEM + 30% fetal bovine serum + antibiotic mixture) is used. Group: Biochemicals. Alternative Names: Methyl Sulfoxide; Dimethylsulfoxide; DMSO. Grades: Cell Culture Grade. CAS No. 67-68-5. Pack Sizes: 5x5ml, 5x10ml, 25ml, 50ml, 100ml. Molecular Formula: C2H6SO, Molecular Weight: 78.13. US Biological Life Sciences. | Worldwide |
| Dipeptidyl Peptidase 3 (DPP3), GST-Tag, Recombinant, Human (Lyophilized) | Human DPP3 (GenBank Accession No. NM_130443), (full length) with N-terminal GST tag, expressed in a Baculovirus infected Sf9 cell expression system. Group: Molecular Biology. Grades: Purified. Pack Sizes: custom. US Biological Life Sciences. | Worldwide |
| Diphenhydramine Citrate | Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic. Group: Biochemicals. Grades: Highly Purified. CAS No. 88637-37-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C23H29NO8. US Biological Life Sciences. | Worldwide |
| Discrete-HA Oligomeric-HA8 | Discrete-HA Oligomeric-HA8 is a monodisperse octameric hyaluronic acid. Hyaluronic acid contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: NA, Molecular Weight: 1535.3. US Biological Life Sciences. | Worldwide |
| Disulfoton-D10 | Isotope labelled Disulfoton (D493695), which is an organophosphate acetylcholinesterase inhibitor (1) binding to muscarinic receptors (2), is most commonly used for its pesticidal & insecticidal properties in the agricultural industry. Disulfoton and degredation products may be found in soil (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C8H9D10O2PS3, Molecular Weight: 284.47. US Biological Life Sciences. | Worldwide |
| Divin (DIVision Inhibitor, N-((E)-(2-Hydroxynaphthalen-1-yl)methylidene)-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide, (E)-N-((2-Hydroxynaphthalen-1-yl)methylene)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)propanehydrazide) | A cell-permeable, stable benzimidazolylpropane hydrazone that acts as a potent bacteriostatic agent and reduces the growth rate and transmembrane potential of bacterial cells without altering their membrane permeability. Blocks bacterial cell division by disturbing divisome assembly and causing dissociation of late division proteins from the divisome (MIC = 3, 5, 12.5, and 12.5uM against V. cholerae, C. crescentus CB15N strain and JW5503 and YJE24 strains of E. coli, respectively). Also shown to reduce peptidoglycan remodeling and arrest the constriction in dividing cells. Does neither affect the tubulin homologue, FtsZ, nor interfere with replication, partitioning, and orientation of chromosomes. Exhibits low toxicity in mammalian cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| DL-Ethyl Lactate | DL-Ethyl Lactate is a green and environmentally benign solvent with effectiveness comparable to petroleum-based solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 97-64-3. Pack Sizes: 1g, 10 g. Molecular Formula: C5H10O3. US Biological Life Sciences. | Worldwide |
| DL-Lysine Hydrochloride 99+% | Appearance: White to off-white crystalline powder. Group: Biochemicals. Alternative Names: DL-Lys-OH·HCl; (R,S)-2,6-Diaminohexanoic acid monohydrochloride. Grades: Highly Purified. CAS No. 70-53-1. Pack Sizes: 50g, 250g. US Biological Life Sciences. | Worldwide |
| Dl-lysine monohydrate | Dl-lysine monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 885701-25-7. Pack Sizes: 500mg, 1g. Molecular Formula: C6H16N2O3, Molecular Weight: 164.2. US Biological Life Sciences. | Worldwide |
| DL-Panthenol | DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair. Group: Biochemicals. Grades: Highly Purified. CAS No. 16485-10-2. Pack Sizes: 1g, 10g. Molecular Formula: C9H19NO4. US Biological Life Sciences. | Worldwide |
| DMBO (CCDC-272761) | An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-a and heparin-binding-EGF in a surface plasmon resonance assay. At concentrations of 10-80uM, this compound dose-dependently inhibits the proliferation of VEGF-expressing LM8G7 cells (IC50=13uM), and TNF-a-expressing OVSAHO cells (IC50=19uM). At 195uM, a 99% reduction in cell growth is observed in HB-EGF-expressing SKOV-3 cultures. This compound inhibits heparanase-mediated degradation of heparin sulfate in LM8G7 cells (IC50=65uM and 104-206uM, in an enzymatic and a cell based assay, respectively). At 0.5-5uM, it markedly prevents the migration and invasion of the same culture, in a dose-dependent manner. In addition, it completely suppresses liver metastatic nodules of osteosarcoma mice injected with LM8G7 cells at 0.5mg/kg without any signs of toxicity in vivo, and demonstrates a synergistic anti-tumor effect when Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| DNA Methyltransferase Inhibitor V, RSC133 (DNA MTase Inhibitor V, (E) -3- (3- (1H-Indol-3-yl) acrylamido) benzamide, ID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133) | A cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-binding site and enhance the efficiency of iPSC production from both murine MEF (10uM starting 5 d post KSOM viral infection) and human foreskin fibroblast (10uM starting same day as or 5 d post KSOM viral infection) cultures with accompanying cellular Dnmt1 activity reduction, affecting hFF viability only at high concentrations (78% of control post 72h 100uM treatment). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: Dnmt1. US Biological Life Sciences. | Worldwide |
| DNQX Disodium Salt (AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX) | A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66uM and 0.35uM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate andnMDA receptors in studying brain functions and disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 2379-57-9. Pack Sizes: 10mg. Molecular Formula: C?H?N?O?Na?, Primary Target: AMPA. US Biological Life Sciences. | Worldwide |
| Docosahexaenoic Acid-13C22 | 13C22 labelled of docosahexaenoic acid (D494500). Omega-3 fatty acid found in marine fish oils and in many phospholipids. Major structural component of excitable membranes of the retina and brain; synthesized in the liver from α-linolenic acid. Nutritional supplement. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: 13C22H32O2, Molecular Weight: 350.33. US Biological Life Sciences. | Worldwide |
| Doramapimod (1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea, BRRB 796) | Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors, doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Group: Biochemicals. Grades: Highly Purified. CAS No. 285983-48-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Doxepin-13C3 | Doxepin-13C3 is a derivative of Doxepin Hydrochloride (D550000), which is used clinically to treat anxiety and depression. Doxepin is an antidepressant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1613C3H21NO, Molecular Weight: 282.35. US Biological Life Sciences. | Worldwide |
| DP2 Antagonist I (CRTH2 Antagonist I, GPR44 Antagonist I, (4-Chloro-2- ( (2-methyl-5- (propylsulfonyl) phenyl) ethynyl) phenoxy) acetic Acid) | A cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 2.0 and 2.4nM against 1.5nM PGD2 for human & murine DP2 binding, respectively), exhibiting much reduced potency against DP1 (Ki = 1.58uM; IC50 = 10uM), PGE receptor EP2 (54% inhibition at 10uM), and little or no activity toward 49 other receptors and ion channels. Effectively inhibits PGD2-induced cellular activation (IC50 = 32 and 80nM, respectively, using CHO-CRTH2 or human whole blood) in vitro and is efficacious in alleviating airway eosinophil infiltration in OVA-sensitized mice (30mg/kg; p.o.) in vivo with good oral bioavailability. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??ClO?S. US Biological Life Sciences. | Worldwide |
| DP2 Antagonist II (CRTH2 Antagonist II, GPR44 Antagonist II, (R)-(5-Chloro-1'-(5-chloro-2-fluorobenzyl)-2,2',5'-trioxospiro(indole-3,3?-pyrrolidin)-1(2H)-yl)acetic Acid) | The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 receptor CRTH2/DP2 (Ki = 5.3 and 5.0nM against human & murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I, but less oral bioavailability in mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??Cl?FN?O?. US Biological Life Sciences. | Worldwide |
| DPDPE (Delta Opioid Receptor Agonist, DPDPE) | A potent agonist selective for delta opioid receptor (EC50 = 5.2nM). Exhibits anti-convulsant effects in vivo in rats, also used in nociceptive studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 88373-73-3. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?S?, Peptide Sequence: Tyr-D-Pen-Gly-Phe-D-Pen (2-5 disulfide bond). US Biological Life Sciences. | Worldwide |
| DTSSP Crosslinker | DTSSP crosslinker is membrane-impermeable, thus enabling cell-surface crosslinking without interfering with intercellular proteins. Group: Biochemicals. Alternative Names: 1-3- [3- (2, 5-dioxo-3-sulfopyrrolidin-1-yl ) oxy-3-oxopropyl ] disulfanyl propanoyl oxy] -2, 5-dioxopyrrolidine-3-sulfonic acid; Sulfo-DSP; DTBSSP. Grades: Purified. CAS No. 81069-02-5. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| DTSSP Crosslinker (Sulfo-DSP; DTBSSP) | DTSSP is a water-soluble crosslinking agent with primary amine-reactivity, N-hydroxysulfosuccinimi de (Sulfo-NHS) esters at both ends and contains a cleavable, 8-atom (12A?) spacer arm. The disulfide bond in the spacer arm is cleavable with reducing agents such as DTT, TCEP, etc. DTSSP crosslinker is membrane-impermeable, thus enabling cell-surface crosslinking without interfering with intercellular proteins. Group: Biochemicals. Alternative Names: 1-? [3-? [3-? (2, 5-dioxo-?3-sulfopyrrolidin-1-yl ) oxy-3-oxopropyl ] disulfanyl propanoyl oxy] -2, 5-dioxopyrrolidine-3-sulfonic acid; Sulfo-DSP; DTBSSP. Grades: Highly Purified. CAS No. 81069-02-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| DUB Inhibitor IV, b-AP15 (NSC687852, 3, 5-bis ( (4-Nitrophenyl) methylidene) -1-prop-2-enoylpiperidin-4-one, (3E, 5E) -1-Acryloyl-3, 5-bis (4-nitrobenzylidene) piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II) | A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50=2.1uM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50=0.8uM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.4. US Biological Life Sciences. | Worldwide |
| DUB Inhibitor VI, P22077 (1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone, USP7 Inhibitor II, USP47 Inhibitor II) | A cell-permeable thiophenylethanone that is shown to inhibit USP7 and USP47 deubiquitinase activity (IC50=8.01 & 8.74uM, respectively), while exhibiting much reduced affinity toward ATXN3, BAP1, and USP1, and displaying no inhibitory activity toward other known PR-619 targets (IC50 >50uM). Both P22077 and PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however PR619 treatment results in upregulation of both K48- and K63-linked, while P22077 exposure results in mainly enrichment of K48-linked polyUb chains. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| DUB Inhibitor V, PR-619 | A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains. Group: Biochemicals. Alternative Names: PR619; UCH-L1 Inhibitor IV; UCH-L3 Inhibitor II; UCH-L5/UCH37 Inhibitor III; USP5 Inhibitor II; USP7 Inhibitor I; USP9X Inhibitor II; USP14 Inhibitor IV; USP14 Inhibitor IV; USP47 Inhibitor I; 2,6-Diaminopyridine-3,5-bis(thiocyanate); 3,5-Dithiocyanatopyridine-2,6-diamine. Grades: Highly Purified. CAS No. 21645-32-1. Pack Sizes: 25mg. Molecular Formula: C?H?N?S?, Molecular Weight: 223.3. US Biological Life Sciences. | Worldwide |
| Dynamin Inhibitor V, 34-2 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide) | A cell-permeable, allosteric Dynamin inhibitor (IC50=6.9uM and 14uM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10uM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50=4.0 - 37uM). It was further shown to be 6-fold more active (IC50=5.0uM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50=1.3uM) than Dynasore in another Dynamin I GTPase activity assay. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Dynorphin A (1-17) (Kappa Opioid Receptor Agonist) | An endogenous agonist for kappa opioid receptors. Involved in several neurological disorders, including neuropathic pain, stress, depression, and Alzheimer's and Parkinson's diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 80448-90-4. Pack Sizes: 500ug, 1mg, 5mg, 10mg. Molecular Formula: C99H155N31O23, Molecular Weight: 2147.5. US Biological Life Sciences. | Worldwide |
| (E)-3-Chloro-2-propen-1-ol | (E)-3-Chloro-2-propen-1-ol is an intermediate in synthesizing trans-1,3,3-Trichloro-1-propene (T773965), a reagent in the oxidation of trichlorovinyl compounds and tetrachloroethylene during epoxidation. Group: Biochemicals. Grades: Highly Purified. CAS No. 4643-6-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C3H5ClO. US Biological Life Sciences. | Worldwide |
| EBP1 Inhibitor, WS6 (N- (6- (4- (2- (4- ( (4- methyl piperazin-1-yl) methyl ) -3- (trifluoro methyl ) phenylamino) -2-oxoethyl) phenoxy) pyrimidin-4-yl) cyclopropane carboxamide, xHCl, Erb3 Binding Protein-1 Inhibitor, IKK Inhibitor XV, PA2G4 Inhibitor) | A cell-permeable phenoxypyrimidin-cyclopropane carboxamide compound that effectively stimulates the growth of primary beta cells in cultured primary rat and human islets in vitro (ECmax in 4 d = 200 and 400nM, respectively) and in the murine type 1 diabetes (T1D) model RIP-DTA in vivo (170% of control pancreas Ki-67-positive beta cells in 1 wk; 5mg/kg i.p. q.o.d.) by interacting with IKKε and EBP1/PA2G4/Erb3 binding protein-1 and blocking the known suppressor function of EBP1 toward E2F-mediated transcription. Likewise, dual inhibition of EBP1 (with shRNA) and IKK (1uM) is shown to fully recapitulate the proliferating effect of WS6 in R7T1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?; xHCl. US Biological Life Sciences. | Worldwide |
| Echinomycin (Quinomycin A) | Antibiotic. Antitumor compound. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent hypoxia-inducible factor 1 (HIF-1) DNA binding activity inhibitor. Apoptosis inducer. Antibacterial, antifungal and antiviral. Group: Biochemicals. Alternative Names: Echinomycin, Actinoleukin, Antibiotic 1491, Antibiotic 59266, Antibiotic X 948, Antibiotic X 53III; N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester. Grades: Highly Purified. CAS No. 512-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H64N12O12S2. US Biological Life Sciences. | Worldwide |
| Echinosporin (NSC357683, XK 213, (1S, 4aS, 5S, 7aS) -5-Hydroxy-8-oxo-1, 4a, 5, 7a-tetrahydro-1, 5- (epoxymethano) cyclopenta[c] pyran-3-carboxamide) | Antibiotic. Cell cycle inhibitor at the G(2)/M phase. Antitumor compound. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 79127-35-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| eEF2K Inhibitor, A-484954 (7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic Elongation Factor-2 Kinase Inhibitor, A-484954) | A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50=280nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.CAS No.142557-61-7. Group: Biochemicals. Grades: Highly Purified. CAS No. 142557-61-7. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 289.3. US Biological Life Sciences. | Worldwide |
| eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1, 2, 3]thiadiazol-6-yl)-3-(3, 4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) | A cell-permeable N,N'-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2a in cells at 10uM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175mg/kg, in vivo.CAS No:1257423-87-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 1257423-87-2. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N?OS, Molecular Weight: 339.2. US Biological Life Sciences. | Worldwide |
| eIF2-GTP-tRNAiMet Ternary Complex Inhibitor Negative Control, NCPdCPU (1-(2-chloro-5-nitrophenyl)-3-(3,4-dichlorophenyl)urea) | A negative control for eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| EIPA (Ethylisopropyl Amiloride, 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide) | EIPA (Ethylisopropyl Amiloride, 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide). Group: Biochemicals. Grades: Highly Purified. CAS No. 1154-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Elaiophylin (Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846I, Gopalamicin, Salbomycin, Azalomycin B, SNA 4606-3) | Antibiotic. Active against Gram-positive bacteria, protozoa and tumors. Testosterone 5alpha-reductase inhibitor. Nitric oxide synthase (NOS) inhibitor. Immunosuppressive and enhances the antifungal activity of rapamycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 37318-06-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Elasnin (3,5-Dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)-2H-pyran-2-one) | Inhibitor of human leukocyte elastase (IC50=1.3ug/ml), different other elastases and chymotrypsin (IC50=82ug/ml). Group: Biochemicals. Grades: Highly Purified. CAS No. 68112-21-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Elastase Inhibitor V (2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one) | A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8nM), but not O2 - generation, in fLMP-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Eliprodil (alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX) | A negative allosteric modulator selective for NR2B containingnMDA receptors (IC50 = 1, >100, and >100uM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for alpha1 receptor (Ki = 0.013uM), one of the two types of unique non-opioid, non-phencyclidine brain alpha receptors. Blocks neuronal voltage-gated Ca2+. Group: Biochemicals. Grades: Highly Purified. CAS No. 119431-25-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Elmycin B ((1aR, 3S, 5bR, 11S, 11aR, 11bR)-10, 11, 11a-Trihydroxy-3-methyl-3, 4, 5b, 11, 11a, 11b-hexahydrotetrapheno[5, 6-b]oxirene-5, 6(1aH, 2H)-dion) | Antibiotic. Antibacterial. Moderate cytotoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 128233-09-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Elzasonan | Elzasonan is a selective 5-hydroxytryptamine 1B receptor antagonist that was developed by Pfizer (and then later discontinued in 2008) to treat patients with major depressive disorder and obsessive compulsive disorder. Group: Biochemicals. Grades: Highly Purified. CAS No. 361343-19-3. Pack Sizes: 50mg, 500mg. Molecular Formula: C22H23Cl2N3OS, Molecular Weight: 448.41. US Biological Life Sciences. | Worldwide |
| Emapunil (AC-5216, XBD-173) | Emapunil (AC-5216, XBD-173) is a translocator protein, TSPO 18kD ligand. Group: Biochemicals. Alternative Names: N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide. Grades: Highly Purified. CAS No. 226954-04-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ENA Extract, Bovine, Rabbit | ENA Extract is a pool of rabbit and/or bovine tissue extracts that will form precipitins with autoantibodies that bind Sm, Ro/SS-A, La/SS-B, nRNP, Scl-70, and Jo-1 when tested by immunodiffusion. Group: Biologicals. Grades: Purified. Pack Sizes: 250ul. US Biological Life Sciences. | Worldwide |
| EphA Antagonist (4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid, EphA2 Antagonist, EphA4 Antagoinst, Ephrin Receptor Antagonist, Rtk2 Antagonist, Rtk1 Antagonist) | A pyrrolyl benzoic acid that effectively competes against ephrin-B3 for EphA4 binding as well as against ephrin-A1/-A2/-A3/-A5 for EphA2 and EphA4 binding by targeting EphA2/A4 high affinity ephrin-binding pocket in a reversible manner, exhibiting much reduced or no potency against ephrin-A4 for EphA2/EphA4 binding, ephrin-A5 for EphA3/A5/A6/A7 binding, ephrin-B2 for B1/B2/B3/B4/B6 binding, or ephrin-B2 for EphA4 binding. Shown to inhibit ephrin-A1-induced EphA2 phosphorylation (by 92% at 200uM) and ephrin-A5-induced EphA4 phosphorylation (by 79% at 400uM) in cultures in vitro and prevent ephrin-A5-induced growth cone collapse of neurons in 6-d chicken embryo retina (by 100% at 400uM) ex vivo, as well as rescue human mutant SOD-1 A4V transgene-induced axonopathy in zebrafish embryos (500uM from 6 to 30hpf) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| epi-Aszonalenin A (Epiaszonalenin A) | Derivative of aszonalenin, a substance P inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 908853-14-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H25N3O3. US Biological Life Sciences. | Worldwide |
| (±)-Epibatidine Dihydrochloride (2-(6-chloropyridin-3-yl)-7-azabicyclo[2. 2. 1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine) | A potent partial agonist selective for alpha7 nAChRs (EC50 = 34uM). Widely used in investigating the roles of alpha7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 501684-93-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClN? 2HCl xH2O. US Biological Life Sciences. | Worldwide |
| Epicatechin 5-O- β-D-glucuronide | Epicatechin 5-O- β-D-glucuronide is a product from the metabolism of [2-14C](-)-epicatechin ingested by rats. Endothelial cells contributes significantly to metabolism of Epicatechin 5-O- β-D-glucuronide. Group: Biochemicals. Grades: Highly Purified. CAS No. 223614-70-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22O12, Molecular Weight: 466.39. US Biological Life Sciences. | Worldwide |
| Epithelial Cell Extract, Human | Human epithelial cell extract. Contains the following antigenic components from human whole cell extract as tested by western blot: SS-A (Ro) with 60kD and 52kD bands, SS-B (La) with 50kD band (note that the SS-A 52kD and the SS-B 50kD bands overlap due to their size), Scl-70 (topoisomerase I) with 105kD band, RNP with 68kD and 33kD bands, Smith with 26kD and 25kD bands, Jo-1 with 53kD band, and Ribosomal P with 38kD band. Bands are present using Western blot qualified antisera. Other antigens may be present. Group: Biologicals. Grades: Purified. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Epoxomicin | Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Group: Biochemicals. Alternative Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide, BU 4061T. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 100ug, 250ug, 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 554.7. US Biological Life Sciences. | Worldwide |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.