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Fmoc-D-Thr(Trt)-OH
Standard building block of introduction of D-threonine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Thr(Trt)-OH, N-α-Fmoc-O-trityl-D-threonine / (2R,3S). Product Category: Amino Acids. CAS No. 682800-84-6. Mole weight: 583.67. Product ID: ACM682800846-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-D-Tic-OH
Standard building block of introduction of D-Tic amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Tic-OH, N-1-Fmoc-D-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid. Product Category: Amino Acids. CAS No. 130309-33-0. Mole weight: 399.44. Product ID: ACM130309330. Alfa Chemistry ISO 9001:2015 Certified. Categories: (3R)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
Fmoc-D-Trp(Boc)-OH
Standard building block of introduction of D-tryptophan amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Trp(Boc)-OH, N-α-Fmoc-N-in-t.-Boc-D-tryptophan. Product Category: Amino Acids. CAS No. 163619-04-3. Molecular formula: C31H30N2O6. Mole weight: 526.58. Product ID: ACM163619043. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-D-Trp-OH
Standard building block of introduction of D-tryptophan amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Trp-OH, N-α-Fmoc-D-tryptophan. Product Category: Amino Acids. CAS No. 86123-11-7. Mole weight: 426.46. Product ID: ACM86123117. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-D-Tyr(tBu)-OH
Standard building block of introduction of D-tyrosine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Tyr(tBu)-OH, N-α-Fmoc-O-t.-butyl-D-tyrosine. Product Category: Amino Acids. CAS No. 118488-18-9. Molecular formula: C28H29NO5. Mole weight: 459.53. Product ID: ACM118488189. Alfa Chemistry ISO 9001:2015 Certified. Categories: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid.
Fmoc-D-Val-OH
Standard building block of introduction of D-valine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-D-Val-OH, N-α-Fmoc-D-valine. Product Category: Amino Acids. CAS No. 84624-17-9. Molecular formula: C20H21NO4. Mole weight: 339.39. Purity: Peak Area by HPLC ≥95%. Product ID: ACM84624179. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoic acid.
Fmoc-γ-azidohomoalanine
A useful tool for the synthesis of branched, side-chain modified, cyclic peptides and peptide tools for click chemistry by Fmoc SPPS. The side-chain azido group is completely stable to piperidine and TFA, but can be readily converted to an amine on the solid phase or in solution by reduction with thiols or phosphines. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-γ-azidohomoalanine. Product Category: Amino Acids. CAS No. 942518-20-9. Molecular formula: C19H18N4O4. Mole weight: 366.37. Purity: Peak Area by HPLC ≥95%. Product ID: ACM942518209. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gla(OtBu)2-OH
Fmoc-Gla(OtBu)2-OH is a building block for the introduction of γ-carboxyglutamic acid (Gla). γ-Carboxylation of glutamic acid is a rare post-translational modification that occurs in blood coagulation factors and in some snake and cone snail venoms. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gla(OtBu)2-OH, Fmoc-γ-carboxy-Glu(OtBu) 2-OH, Fmoc-gamma-carboxy-L-glutamic acid gamma,gamma-di-t-butyl ester. Product Category: Amino Acids. CAS No. 111662-64-7. Molecular formula: C29H35NO8. Mole weight: 525.59. Purity: Peak Area by HPLC ≥95%. Product ID: ACM111662647-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gln(Dmcp)-OH
A superior derivative to Fmoc-Gln(Trt)-OH for the synthesis of Gln-containing peptides by Fmoc SPPS. Fmoc-Gln(Dmcp)-OH is more soluble in DMF than Fmoc-Gln(Trt)-OH, thereby facilitating coupling reactions at higher concentration. Cleavage of the Dmcp group is rapid, even when the residue is located at the N-terminus of a peptide. Coupling of Dmcp-protected derivatives is faster than that of the corresponding hindered Trt derivatives. Dmcp-protected peptides have enhanced solubility. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln(Dmcp)-OH, N-α-Fmoc-N-γ-(1-cyclopropyl-1-methylethyl)-L-glutamine. Product Category: Amino Acids. CAS No. 172947-20-5. Mole weight: 450.53. Product ID: ACM172947205. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gln-OH
Building block for introduction of glutamine by Fmoc SPPS. Not compatible with uronium and phosphonium coupling reagents. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln-OH, N-α-Fmoc-L-glutamine. Product Category: Amino Acids. CAS No. 71989-20-3. Mole weight: 368.38. Product ID: ACM71989203. Alfa Chemistry ISO 9001:2015 Certified. Categories: N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine.
Fmoc-Gln(Trt)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Fmoc-Gln(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp. Literature references P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln(Trt)-OH, N-α-Fmoc-N-γ-trityl-L-glutamine. Product Category: Amino Acids. CAS No. 132327-80-1. Molecular formula: C39H34N2O5. Mole weight: 610.7. Product ID: ACM132327801. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid.
Fmoc-Gln(Trt)-OPfp
Pre-formed pentafluorophenyl ester for coupling of glutamine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln(Trt)-OPfp, N-α-Fmoc-N-γ-trityl-L-glutamine pentafluorophenyl ester. Product Category: Amino Acids. CAS No. 132388-65-9. Mole weight: 776.75. Product ID: ACM132388659-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu-O-2-PhiPr
An excellent tool for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS. The 2-PhiPr group can be selectively removed on the resin with 1% TFA in DCM in the presence of the standard t-butyl-based side-chain protecting groups. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-O-2-PhiPr, N-α-Fmoc-L-glutamic acid α-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 207305-97-3. Mole weight: 487.54. Product ID: ACM207305973-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(O-2-PhiPr)-OH
Quasi-orthogonally-protected Glu derivative. The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Glu(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(O-2-PhiPr)-OH, N-α-Fmoc-L-glutamic acid γ-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 200616-39-3. Mole weight: 487.54. Product ID: ACM200616393-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu-OAll
Orthogonally-protected building block for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS.The α-allyl ester can be selectively removed in the presence of Fmoc- and tBu-based protecting groups by treatment with Pd(Ph3P)4/ CHCl3/AcOH/NMM, thereby facilitating the synthesis of branched esters and amides, and lactones and lactams incorporating a glutamyl unit. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-OAll, N-α-Fmoc-L-glutamic acid α-allyl ester. Product Category: Amino Acids. CAS No. 144120-54-7. Molecular formula: C23H23NO6. Mole weight: 409.43. Product ID: ACM144120547. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic-acid-alpha allyl ester.
Fmoc-Glu(OAll)-OH
Orthogonally-protected building block for the synthesis of peptides modified at the Glu side chain by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OAll)-OH. Product Category: Amino Acids. CAS No. 133464-46-7. Molecular formula: C23H23NO6. Mole weight: 409.43. Product ID: ACM133464467. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu-OBzl
Building block for introduction of aspartic acid bearing TFA-labile benzyl ester protection. Benzyl group is removed by hydrogenation over Pd/C or with strong acids such as TFMSA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-OBzl, N-α-Fmoc-L-glutamic acid α-benzyl ester. Product Category: Amino Acids. CAS No. 122350-52-1. Mole weight: 459.49. Product ID: ACM122350521-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OBzl)-OH
Building block for introduction of glutamic acid bearing TFA-labile benzyl ester side-chain protection. Benzyl group is removed by hydrogenation over Pd/C or with strong acids such as TFMSA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OBzl)-OH, N-α-Fmoc-L-glutamic acid γ-benzyl ester. Product Category: Amino Acids. CAS No. 123639-61-2. Mole weight: 459.49. Product ID: ACM123639612. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID10553436.
Fmoc-Glu-ODmab
Quasi-orthogonally-protected Glu derivative. The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Glu(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-ODmab, N-α-Fmoc-L-glutamic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester. Product Category: Amino Acids. CAS No. 172611-75-5. Mole weight: 680.79. Product ID: ACM172611755. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu-OtBu
Selectively protected building block for library synthesis or the preparation of γ-glutamyl peptides by Fmoc SPPS. After condensation of the side-chain carboxy with an appropriate amine or alcohol, the γ-amino and carboxy functions can be selectively unmasked with 20% piperidine in DMF and 50% TFA in DCM respectively, facilitating the synthesis of branched esters, amides, lactams and lactones containing the glutamyl unit. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-OtBu, N-α-Fmoc-L-glutamic acid α-t.-butyl ester. Product Category: Amino Acids. CAS No. 84793-07-7. Molecular formula: C24H27NO6. Mole weight: 425.47. Product ID: ACM84793077. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OtBu)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of glutamic acid amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OtBu)-OH, N-α-Fmoc-L-glutamic acid γ-t.-butyl ester. Product Category: Amino Acids. CAS No. 71989-18-9. Molecular formula: C24H27NO6. Mole weight: 425.47. Product ID: ACM71989189-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OtBu)-Ser(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Glu-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OtBu)-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 909115-33-9. Mole weight: 552.62. Product ID: ACM909115339-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of glycine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gly-OH, FMOC-Glycine, N-α-Fmoc-glycine. Product Category: Amino Acids. CAS No. 29022-11-5. Molecular formula: C17H15NO4. Mole weight: 297.31. Product ID: ACM29022115. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OH-13C2,15N
Fmoc-Gly-OH-13C2,15N. Uses: Peptide synthesis. Additional or Alternative Names: N-(9-Fluorenylmethoxycarbonyl)-glycine-13C2,15N, Glycine-13C2,15N, N-Fmoc. Product Category: Amino Acids. CAS No. 285978-13-4. Molecular formula: (H15N-Fmoc)13CH213CO2H. Mole weight: 300.28. Canonical SMILES: O[13C](=O)[13CH2][15NH]C(=O)OCC1c2ccccc2-c3ccccc13. Product ID: ACM285978134-3. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OH (15N)
Fmoc-Asp(OtBu)-OH is an aspartate derivative containing amine-protecting group Fmoc. Uses: Peptide synthesis. Additional or Alternative Names: N-(9-Fluorenylmethoxycarbonyl)-glycine-15N, Glycine-15N, N-Fmoc. Product Category: Amino Acids. CAS No. 125700-33-6. Molecular formula: (15NH-Fmoc)CH2CO2H. Mole weight: 298.3. Purity: 98 atom % 15N. Canonical SMILES: OC(=O)C[15NH]C(=O)OCC1c2ccccc2-c3ccccc13. Product ID: ACM125700336-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OH-2-13C
Fmoc-Gly-OH-2-13C. Uses: Peptide synthesis. Additional or Alternative Names: N-(9-Fluorenylmethoxycarbonyl)-glycine-2-13C, Glycine-2-13C, N-Fmoc. Product Category: Amino Acids. CAS No. 175453-19-7. Molecular formula: (HN-Fmoc)13CH2CO2H. Mole weight: 298.3. Canonical SMILES: OC(=O)[13CH2]NC(=O)OCC1c2ccccc2-c3ccccc13. Product ID: ACM175453197-2. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OH (U-13C2, 15N)
Fmoc-Asp(OtBu)-OH is an aspartate derivative containing amine-protecting group Fmoc. Uses: Peptide synthesis. Product Category: Amino Acids. CAS No. 285978-13-4. Molecular formula: Fmoc-15NH-13CH213COOH. Mole weight: 300.3. Purity: 99 atom % 13C 98 atom % 15N. Canonical SMILES: O[13C](=O)[13CH2][15NH]C(=O)OCC1c2ccccc2-c3ccccc13. Product ID: ACM285978134-2. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gly-OPfp
Pre-formed pentafluorophenyl ester for coupling of glycine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gly-OPfp, N-α-Fmoc-glycine pentafluorophenyl ester. Product Category: Amino Acids. CAS No. 86060-85-7. Mole weight: 463.35. Product ID: ACM86060857-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hArg(Pbf)-OH
Fmoc-homoArg(Pbf)-OH is a useful tool for the introduction of homoarginine during Fmoc SPPS. It can be used in exactly the same manner as Fmoc-Arg(Pbf)-OH. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-hArg(Pbf)-OH, N-α-Fmoc-N G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-homoarginine. Product Category: Amino Acids. CAS No. 1159680-21-3. Molecular formula: C35H42N4O7S. Mole weight: 662.8. IUPACName: (2R)-6-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxycarbonylamino)hexanoic acid. Canonical SMILES: CC1=C(C(=C(C2=C1OC(C2)(C)C)C)S(=O)(=O)NC(=NCCCCC(C(=O)O)NC(=O)OCC3C4C=CC=CC4C5C3C=CC=C5)N)C. Product ID: ACM1159680213. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hCys(Trt)-OH
Fmoc-homoCys(Trt)-OH is a useful tool for the introduction of homocysteine during Fmoc SPPS. It can be used in exactly the same manner as Fmoc-Cys(Trt)-OH. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-hCys(Trt)-OH, Fmoc-S-trityl-L-homocysteine. Product Category: Amino Acids. CAS No. 167015-23-8. Molecular formula: C38H33NO4S. Mole weight: 599.74. Product ID: ACM167015238. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hGlu(OtBu)-OH
A useful homolog of glutamic acid for the study of protein-protein interactions, tumor targeting, and SAR studies. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-hGlu(OtBu)-OH, Fmoc-L-α-homoglutamic acid 6-t-butyl ester,(S)-2-(Fmoc-amino)adipic acid 6-t-butyl ester. Product Category: Amino Acids. CAS No. 159751-47-0. Mole weight: 439.5. Product ID: ACM159751470. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-His(Boc)-OH-CHA
The N-im-Boc group is unstable to prolonged treatment with piperidine ; the utility of this derivative is therefore limited to the preparation of short sequences by Fmoc SPPS. This derivative is supplied as a CHA-salt. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-His(Boc)-OH-CHA, N-α-Fmoc-N-im-t.-Boc-L-histidine cyclohexylammonium salt. Product Category: Amino Acids. CAS No. 210820-99-8. Mole weight: 477.51. Product ID: ACM210820998-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-His(Clt)-OH
A useful derivative for the convergent synthesis of peptide due to the enhanced stability of Clt group compared to Trt group to mildy acidic reagents. Fmoc-His-(Clt)-OH gives approximately a third less racemization when compared to Fmoc-His(Trt)-OH during slow coupling reactions. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-His(Clt)-OH, N-α-Fmoc-N-im-2-chlorotrityl-L-histidine. Product Category: Amino Acids. CAS No. 224032-19-3. Mole weight: 654.15. Product ID: ACM224032193-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-His(Mtt)-OH
The Mtt group can be removed from the side-chain of histidine by treatment with dilute TFA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-His(Mtt)-OH, N-α-Fmoc-N-im-methyltrityl-L-histidine. Product Category: Amino Acids. CAS No. 133367-34-7. Mole weight: 633.73. Product ID: ACM133367347-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-His(Trt)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of histidine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-His(Trt)-OH, N-α-Fmoc-N-im-trityl-L-histidine. Product Category: Amino Acids. CAS No. 109425-51-6. Molecular formula: C40H33N3O4. Mole weight: 619.71. Product ID: ACM109425516. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hLeu-OH
Standard building block for introduction of homoleucine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-hLeu-OH, Fmoc-homo-L-leucine. Product Category: Amino Acids. CAS No. 180414-94-2. Mole weight: 367.44. Product ID: ACM180414942-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hLys(Boc)-OH
This homolog of lysine has been used to modulate ion-pairing interactions between Lys and enzyme carboxylate groups in SAR studies. Uses: Fmoc-hlys(boc)-oh can be used as a building block in the solid phase peptide synthesis. Additional or Alternative Names: Fmoc-hLys(Boc)-OH, N-α-Fmoc-N-ω-t.-Boc-L-homolysine. Product Category: Amino Acids. CAS No. 194718-17-7. Mole weight: 482.57. Product ID: ACM194718177-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Fmoc-L-Holys(Boc)-OH.
Fmoc-homopropargylglycine
Building block for the introduction by Fmoc SPPS. of an amino acid bearing an alkyne side chain. Such derivatives are useful tools for the synthesis of cyclic peptides by an alkyne-alkyne Glaser coupling, involving Cu(OAc)2/pyridine and heating to 60 °Cusing microwaves. Uses: Fmoc-hpg-oh has a wide range of applications in scientific research. it can be used to synthesize peptides with desirable biological properties such as antimicrobial activity, anticancer activity, and enzyme inhibitory activity. these peptides can be used in drug discovery and development, as well as in the treatment of a wide range of diseases. Additional or Alternative Names: Fmoc-homopropargylglycine. Product Category: Amino Acids. CAS No. 942518-21-0. Molecular formula: C21H19NO4. Mole weight: 349.38. IUPACName: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hex-5-ynoic acid. Canonical SMILES: C#CCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13. Density: 1.265±0.06 g/mL. Product ID: ACM942518210. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-hPhe-OH
Standard building block for introduction of homophenylalanine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-hPhe-OH, Fmoc-homo-L-phenylalanine. Product Category: Amino Acids. CAS No. 132684-59-4. Molecular formula: C25H23NO4. Mole weight: 401.45. Product ID: ACM132684594. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Hse(Trt)-OH
Building block which enables side-chain modification of homoserine serines by Fmoc SPPS. The Trt group can be removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This derivative has been employed to prepare oligonucleotide conjugates. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Hse(Trt)-OH, N-α-Fmoc-O-trityl-L-homoserine. Product Category: Amino Acids. CAS No. 111061-55-3. Mole weight: 583.67. Product ID: ACM111061553. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Hyp-OH
Building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Hyp-OH, N-α-Fmoc-L-trans-4-hydroxyproline. Product Category: Amino Acids. CAS No. 88050-17-3. Mole weight: 353.37. Product ID: ACM88050173. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid.
Fmoc-Hyp(tBu)-OH
Standard building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Hyp(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-trans-4-hydroxyproline, Fmoc-(2S,4R)-(-)-4-t-butoxypyrrolidine-2-carboxylic acid. Product Category: Amino Acids. CAS No. 122996-47-8. Molecular formula: C24H27NO5. Mole weight: 409.47. Product ID: ACM122996478. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S,4R)-4-(tert-butoxy)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid.
Fmoc-Ile-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of isoleucine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Ile-OH, N-α-Fmoc-L-isoleucine. Product Category: Amino Acids. CAS No. 71989-23-6. Molecular formula: C21H23NO4. Mole weight: 353.41. Product ID: ACM71989236. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-Fmoc-L-isoleucine.
Fmoc-Ile-OH-13C6,15N
Fmoc-Ile-OH-13C6,15N. Uses: Peptide synthesis. Additional or Alternative Names: N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine-13C6,15N, L-Isoleucine-13C6,15N, N-Fmoc, 13C and 15N Labeled Fmoc-Ile-OH. Product Category: Amino Acids. CAS No. 1217442-29-9. Molecular formula: 13CH313CH213CH(13CH3)13CH(15NH-Fmoc)13CO2H. Mole weight: 360.36. Canonical SMILES: [13CH3][13CH2][13C@H]([13CH3])[13C@H]([15NH]C(=O)OCC1c2ccccc2-c3ccccc13)[13C](O)=O. Product ID: ACM1217442299-2. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Ile-Thr(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Ile-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Ile-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 957780-52-8. Mole weight: 494.58. Product ID: ACM957780528-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Isn-OH
Standard building block for introduction of isonipecotic acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Isn-OH, N-α-Fmoc-piperidine-4-carboxylic acid, Fmoc-Inp-OH. Product Category: Amino Acids. CAS No. 148928-15-8. Mole weight: 351.4. Product ID: ACM148928158-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-L-(2,6-di-Me)Tyr-OH
Fmoc-2,6-dimethyl-L-tyrosine is a derivative of L-tyrosine, which is one of the 20 naturally occurring amino acids. It is an acronym for 9-Fluorenylmethyloxycarbonyl-2,6-dimethyltyrosine. Fmoc-2,6-dimethyl-L-tyrosine is also referred to as fluorenylmethoxycarbonyl-2,6-dimethyltyrosine or Fmoc-Dmt-OH. Fmoc-Dmt-OH has a molecular weight of 393.45 and a molecular formula of C23H21NO5. Uses: Fmoc-2,6-dimethyl-l-tyrosine has several research applications, including the synthesis of peptides, proteins, and peptidomimetics. it is also used as a building block of combinatorial libraries for the discovery of new drug candidates. fmoc-2,6-dimethyl-l-tyrosine has been incorporated into various bioactive peptides and proteins to improve their stability, activity, and specificity. it has also been used as a precursor for the synthesis of novel peptidomimetics with potential therapeutic applications. Additional or Alternative Names: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-dimethyl-L-tyrosine, Fmoc-2,6-dimethyl-L-tyrosine, (S)-N-Fmoc-2,6-Dimethyltyrosine. Product Category: Amino Acids. CAS No. 206060-54-0. Molecular formula: C26H25NO5. Mole weight: 431.5. Purity: Peak Area by HPLC ≥95%. IUPACName: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid. Canonical SMILES: CC1=CC(=CC(=C1CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C)O. Density: 1.290 g/cm3. Product ID: ACM206060540. Alfa Che
FMoc-L-4-(OtButylcarboxyMethyl)phe-OH
FMoc-L-4-(OtButylcarboxyMethyl)phe-OH. Uses: Designed for use in research and industrial production. CAS No. 222842-99-1. Molecular formula: C30H31NO6. Mole weight: 501.57. Product ID: ACM222842991. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-L-beta -homoalanine
Fmoc-L-beta-homoalanine is a modified form of the amino acid beta-homoalanine, which is naturally found in certain fungi, algae, and invertebrates. It is primarily used as a building block for solid-phase peptide synthesis (SPPS) due to its ability to form stable amide bonds. Fmoc-L-beta-homoalanine is also a useful tool in the study of peptide-protein interactions, as it can serve as a non-natural amino acid substitute. Uses: Fmoc-l-beta-homoalanine has a range of applications in scientific experiments, particularly in the fields of peptide synthesis and drug discovery. it can be used as a building block for the synthesis of various peptides, including antimicrobial peptides and peptidomimetics. it has also been investigated as a potential drug candidate for various diseases, including cancer and infectious diseases. Additional or Alternative Names: Fmoc--HoAla-OH, Fmoc-Beta-HoAla-OH, Fmoc-β-homoalanine, Fmoc-β-HomoAla-OH. Product Category: Amino Acids. CAS No. 193954-26-6. Molecular formula: C19H19NO4. Mole weight: 325.4. Purity: Peak Area by HPLC ≥95%. IUPACName: (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid. Canonical SMILES: CC(CC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13. Density: 1.255 g/cm3. Product ID: ACM193954266-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: (3S)-3-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)BUTANOIC ACID.
Fmoc-L-cysteic acid
Fmoc-L-cysteic acid is an Fmoc protected cysteine derivative potentially useful for proteomics studies, and solid phase peptide synthesis techniques. Cysteine is versatile amino acid involved with many biological processes, including the formation of disulfide bonds - a critical component of protein structure. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function. Uses: Fmoc-l-cysteic acid is an fmoc protected cysteine derivative. Additional or Alternative Names: (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-sulfopropanoic acid. Product Category: Amino Acids. CAS No. 751470-47-0. Molecular formula: C18H17NO7S. Mole weight: 391.4. Purity: ≥ 98% (HPLC). Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CS(=O)(=O)O)C(=O)O. Density: ~1.50 g/cm3. Product ID: ACM751470470. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Leu-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of leucine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Leu-OH, N-α-Fmoc-L-leucine. Product Category: Amino Acids. CAS No. 35661-60-0. Molecular formula: C21H23NO4. Mole weight: 353.41. Product ID: ACM35661600-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Leu-Ser(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Leu-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Leu-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 339531-50-9. Mole weight: 480.55. Product ID: ACM339531509. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Leu-Thr(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Leu-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Leu-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 955048-89-2. Mole weight: 494.58. Product ID: ACM955048892-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-L-selenomethionine
Fmoc-selenomethionine can be introduced under standard conditions. Any selenoxide formed during synthesis can be easily reduced back to selenide by treatment with β-mercaptoethanol. Introduction of selenium can help facilitate solid phase and solution structural determination and the study of peptide-protein interactions. Uses: Fmoc solid-phase peptide synthesis. Additional or Alternative Names: Fmoc-selenomethionine, N-Fmoc-L-amino-4-(methylselanyl)butanoic acid. Product Category: Amino Acids. CAS No. 1217852-49-7. Molecular formula: C20H21NO4Se. Mole weight: 418.4. Purity: Peak Area by HPLC ≥95%. Product ID: ACM1217852497. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-L-Lys(Nvoc)-OH is a lysine derivative compatible with solid-phase peptide synthesis (SPPS). Uses: Photocaged amino acids such as these are useful in the synthesis of photocleavable chemical tools for spatial and temporal control over released molecules in biological applications. Additional or Alternative Names: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-6-((4,5-dimethoxy-2-nitrobenzyloxy)carbonylamino)hexanoic acid, N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(((4,5-dimethoxy-2-nitrobenzyl)oxy)carbonyl)-L-lysine, Lysine with photoremovable NVOC, Photocaged amino acid, Photocleavable lysine derivative. Product Category: Amino Acids. CAS No. 150571-28-1. Molecular formula: C31H33N3O10. Mole weight: 607.6. IUPACName: (2S)-6-[(4,5-dimethoxy-2-nitrophenyl)methoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid. Canonical SMILES: COC1=C(C=C(C(=C1)COC(=O)NCCCCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)[N+](=O)[O-])OC. Density: 1.326±0.06 g/cm3. Product ID: ACM150571281. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(5-FAM)-OH
FMOC-Lys(5-FAM)-OH is a building block for in-sequence Lysine labeling by FAM. FAM is a commonly used donor dye for preparing FRET peptides. Uses: Peptide synthesis. Product Category: Amino Acids. CAS No. 1242933-88-5. Molecular formula: C42H34N2O10. Mole weight: 726.7. Purity: Peak Area by HPLC ≥90%. Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CCCCNC(=O)C4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O)C(=O)O. Product ID: ACM1242933885. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Ac)-OH
Building block for introduction of N-ε-acetyl-lysine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Ac)-OH, N-α-Fmoc-N-ε-acetyl-L-lysine. Product Category: Amino Acids. CAS No. 159766-56-0. Molecular formula: C23H26N2O5. Mole weight: 410.46. Product ID: ACM159766560-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Alloc)-OH
Orthogonally-protected building block for the synthesis of branched and cyclic peptides and peptides modified at the Lys side chain by Fmoc SPPS. The Alloc group can be selectively removed in the presence of standard Fmoc- and t-butyl-based protecting groups by treatment with Pd(Ph3P)4/CHCl3/AcOH/NMM. Uses: Peptide synthesis. Additional or Alternative Names: Nα-Fmoc-Nε-Alloc-L-lysine. Product Category: Amino Acids. CAS No. 146982-27-6. Molecular formula: C25H28N2O6. Mole weight: 452.5. Canonical SMILES: OC(=O)[C@H](CCCCNC(=O)OCC=C)NC(=O)OCC1c2ccccc2-c3ccccc13. Product ID: ACM146982276. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-6-{[(prop-2-en-1-yloxy)carbonyl]amino}hexanoic acid.
Fmoc-Lys(biotin)-OH
A modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(biotin)-OH, N-α-Fmoc-N-ε-biotinyl-L-lysine. Product Category: Amino Acids. CAS No. 146987-10-2. Molecular formula: C31H38N4O6S. Mole weight: 594.72. Purity: Peak Area by HPLC ≥90%. Canonical SMILES: C1C2C(C(S1)CCCCC(=O)NCCCCC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)NC(=O)N2. Density: 1.3±0.1 g/cm3. Product ID: ACM146987102. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(biotinyl-ε-aminocaproyl)-OH
A modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS., in which the biotin is separated from the lysine side-chain by a 6 C-atom spacer. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(biotinyl-ε-aminocaproyl)-OH, N-α-Fmoc-N-ε-(biotinylcaproyl)-L-lysine. Product Category: Amino Acids. CAS No. 160158-05-4. Mole weight: 707.88. Product ID: ACM160158054-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Boc-Abz)-OH
Building block for the preparation of fluorescent labelled peptides. The anthranilic acid attached at the side-chain of lysine is highly sensitive and its fluorescence spectrum does not overlap with those of Trp, Phe, and Tyr. Uses: Peptide synthesis. Additional or Alternative Names: Boc-Abz-(Fmoc-Lys-OH)#Fmoc-ablysin(Boc)-OH. Product Category: Amino Acids. CAS No. 159322-59-5. Molecular formula: C33H37N3O7. Mole weight: 587.6. Purity: Peak Area by HPLC ≥90%. IUPACName: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]amino]hexanoic acid. Canonical SMILES: CC(C)(C)OC(=O)NC1=CC=CC=C1C(=O)NCCCCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24. Density: 1.3±0.1 g/cm3. Product ID: ACM159322595-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Boc)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of lysine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Boc)-OH, N-α-Fmoc-N-ε-t.-Boc-L-lysine. Product Category: Amino Acids. CAS No. 71989-26-9. Molecular formula: C26H32N2O6. Mole weight: 468.54. Product ID: ACM71989269. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Boc)-OH (1-13C)
L-Lysine N-Fmoc/Boc (1-13C) is a protected amino acid used to synthesize isotope-labeled peptides for MS-based protein quantitation. Uses: Biomolecular nmr, proteomics. Additional or Alternative Names: N-α-Fluorenylmethoxycarbonyl-N-ε-tert-butoxycarbonyl-L-lysine. Product Category: Amino Acids. CAS No. 1242058-72-5. Molecular formula: Boc-NH(CH2)4CH(NH-Fmoc)13COOH. Mole weight: 469.5. Purity: Peak Area by HPLC ≥95%. ECNumber: 276-256-4 (Unlabeled). Product ID: ACM1242058725-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Boc)-Thr(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Lys-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Boc)-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 911838-56-7. Mole weight: 609.71. Product ID: ACM911838567-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Dabcyl)-OH
A modified lysine derivative for the preparation of chromogenically-labeled peptides by Fmoc SPPS. The Dabcyl group quenches the fluorescence of EDANS, Mca, TET, JOE, FAM fluorophores, making it an extremely useful tool for the synthesis of fluorescence-quenched peptide substrates. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Dabcyl)-OH. Product Category: Amino Acids. CAS No. 146998-27-8. Molecular formula: C36H37N5O5. Mole weight: 619.71. Product ID: ACM146998278-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Dde)-OH
Quasi-orthogonally-protected Lys derivative for Fmoc SPPS. The Fmoc group can be removed selectively by treatment with piperidine; the Dde group is cleaved with 2% hydrazine in DMF. When removing Dde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group. Lys(Dde) has been employed in the following applications: synthesis of branched peptides and di-epitopic peptides ; preparation of MAP core molecules and lipo-MAPs; construction of cyclic peptides , TASP molecules , templates for combinatorial chemistry and synthetic proteins ; preparation of peptides modified at the lysine side-chain.It has been reported that Dde can migrate from the side-chain of Lys to the unprotected side-chain of another Lys residue , and from the β-amino group to the α-amino group of Dpr. In the former instance, this problem can be overcome by using Fmoc-Lys(ivDde)-OH or using DBU/DMF (2:98) for Fmoc group removal.Full orthogonality of Dde with Fmoc has recently been demonstrated when hydroxylamine is used for Dde removal. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Dde)-OH, N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine. Product Category: Amino Acids. CAS No. 150629-67-7. Molecular formula: C31H36N2O6. Mole weight: 532.63. Product ID: ACM150629677. Alfa Chemistry ISO 9001:2015
Fmoc-Lys(Fmoc)-OH
Useful derivative for the synthesis of branched peptides. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Fmoc)-OH, N-α,ε-di-Fmoc-L-lysine. Product Category: Amino Acids. CAS No. 78081-87-5. Molecular formula: C36H34N2O6. Mole weight: 590.66. Product ID: ACM78081875. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2,6-bis({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid.
Fmoc-Lys(iPr,Boc)-OH
Fmoc-Lys(iPr, Boc)-OH is used for incorporation of N-d-isopropyl-lysine (Lys(iPr)) during Fmoc SPPS. Lys(iPr) has been utilized in the GnRH antagonist Degarelix and the LHRH antagonist Antide. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(iPr,Boc)-OH, N-α-Fmoc-N-ε-isopropyl-N-ε-t.-Boc-L-lysine. Product Category: Amino Acids. CAS No. 201003-48-7. Mole weight: 510.62. Product ID: ACM201003487-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(ivDde)-OH
This orthogonally-protected lysine derivative is based on the hindered Dde variant ivDde. It has very similar chemical properties to Fmoc-Lys(Dde)-OH, except that the side-chain ivDde group is considerably more stable to piperidine than Dde, and is less prone to migrate from protected to unprotected lysine side-chains.When removing ivDde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(ivDde)-OH, N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine. Product Category: Amino Acids. CAS No. 204777-78-6. Molecular formula: C34H42N2O6. Mole weight: 574.71. IUPACName: (2S)-6-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid. Canonical SMILES: CC(C)CC(=C1C(=O)CC(CC1=O)(C)C)NCCCCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24. Density: 1.2±0.1 g/cm3. Product ID: ACM204777786. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Lys(Me)2-OH · HCl
A novel derivative for the introduction of dimethyl-lysine during Fmoc SPPS. Ref contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Lys(Me)2-OH HCl, N-α-Fmoc-N-ε-dimethyl-N-L-lysine · hydrochloride. Product Category: Amino Acids. CAS No. 252049-10-8. Molecular formula: C23H28N2O4·HCl. Mole weight: 396.4·36.5. Product ID: ACM252049108. Alfa Chemistry ISO 9001:2015 Certified.