Alfa Chemistry. - Products
Alfa Chemistry is an ISO 9001:2015 Certified Supplier of various building blocks, reagents, catalysts, nanomaterials, reference materials, and research chemicals. In-stock products can be shipped quickly.
| Product | Description | |
|---|---|---|
| Isostearic Acid | Functions both as an emollient and co-emulsifier. It is a light yellow liquid used in personal care formulations for its function as both an emollient and co-emulsifier. It serves as a smooth, dry feeling emollient able to assist the skin in replenishing its natural moisture. Also, Isostearic Acid when neutralized serves as an extremely effective and stable co-emulsifier used in the preparation of Oil in Water, low viscosity emulsion systems. When incorporated in a formulation in place of stearic acid, it reduces the fatty feel to a non-fatty feel. Uses: Emulsions for skin and hair care products. Group: Surfactants/emulsifiers. CAS No. 30399-84-9. Appearance: White to yellowish clear liquid. Catalog: CI-SC-0246. |  |
| Isostearoyl hydrolyzed collagen | Heterocyclic Organic Compound. Alternative Names: Proteins, hydrolyzates, leather, reaction products with isostearoyl chloride. CAS No. 111174-63-1. Molecular formula: C18H35O. Mole weight: 267.47. Canonical SMILES: CC(C)CCCCCCCCCCCCCC[C]=O. Catalog: ACM111174631. | |
| Isostearyl Neopentanoate | Cosmetic liquid emollient offering smooth application properties and a soft, moisturized after-feel to the skin. Uses: Creams, lotions, shaving creams and cream shampoos. Group: Emollients/oils/wax. CAS No. 58958-60-40. Appearance: Clear light yellow liquid, odorless. Catalog: CI-SC-0427. | |
| Isosteviol | Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects. Group: Inhibitors. Alternative Names: (4α,8β,13β)-13--Methyl-16-oxo-17-norkauran-18-oic acid. CAS No. 27975-19-5. Molecular formula: C20H30O3. Mole weight: 318.45. Appearance: Powder. Purity: 0.98. IUPACName: (1R, 4S, 5R, 9S, 10R, 13S)-5, 9, 13-trimethyl-14-oxotetracyclo[11.2.1.01, 10.04, 9]hexadecane-5-carboxylic acid. Canonical SMILES: C[C@]12CC[C@H]3[C@@]4 (CCC[C@@] ([C@H]4CC[C@@]3 (C1)CC2=O) (C)C (=O)O)C. Density: 1.15±0.1 g/ml. Catalog: ACM27975195. | |
| ISOSTEVIOLMONOSIDE | Stevia. Group: Diterpene glycosides (stevia). CAS No. 1185737-09-0. Mole weight: 480.59. Appearance: White powder. Catalog: ACM1185737090. | |
| Isothebaine | Isothebaine is a benzimidazole compound that acts as a competitive inhibitor of protopine, an enzyme which catalyzes the conversion of tryptophan to 5-hydroxytryptophan. It inhibits the synthesis of serotonin and melatonin. Isothebaine has been shown to have effective analgesic properties in animal models and is used for the treatment of pain. Isothebaine has been shown to have regulatory effects on radiation-induced damage and cervical cancer cell cultures, as well as anti-cancer effects in cell culture models. This drug also inhibits the growth of several types of cancer cells by inhibiting the production of DNA molecules, proteins, and other important cellular components. Isothebaine has also been found to be effective against plant families that are known for causing metabolic disorders. Group: Other alkaloids. CAS No. 568-21-8. Molecular formula: C19H21NO3. Mole weight: 311.37 g/mol. Canonical SMILES: CN1CCC2=CC (=C (C3=C2[C@@H]1CC4=C3C (=CC=C4)OC)O)OC. Catalog: ACM568218. | |
| Isoxanthohumol | Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). Group: Inhibitors. Alternative Names: (±)-Isoxanthohumol. CAS No. 521-48-2. Molecular formula: C21H22O5. Mole weight: 354.4. Appearance: Powder. Purity: 0.98. Canonical SMILES: CC (=CCC1=C (C=C (C2=C1OC (CC2=O)C3=CC=C (C=C3)O)OC)O)C. Catalog: ACM521482. | |
| Isoxazole, 5-(cyclohexylidenemethyl)-(9ci) | Heterocyclic Organic Compound. CAS No. 113352-01-5. Catalog: ACM113352015. | |
| Isoxazolo[4,5-b]pyridin-3-amine | Heterocyclic Organic Compound. Alternative Names: isoxazolo[4,5-b]pyridin-3-amine, 114080-93-2, Isoxazolo[4,5-b]pyridin-3-ylamine, [1,2]oxazolo[4,5-b]pyridin-3-amine, ACMC-209ypk, SureCN2395997, CTK0H0529, MolPort-004-757-692, ANW-49254, AKOS006339655, AG-L-60359, PB21304, RP20183, AK-30698, AM802949, BR-30698, KB-53017, 3-AMINO-ISOXAZOLO[4,5-B]PYRIDINE, Isoxazolo[4,5-b]pyridin-3-amine (9CI), X9078. CAS No. 114080-93-2. Molecular formula: C6H5N3O. Mole weight: 135.123400 [g/mol]. Purity: 0.96. IUPACName: [1,2]oxazolo[4,5-b]pyridin-3-amine. Canonical SMILES: C1=CC2=C(C(=NO2)N)N=C1. Density: 1.421g/cm³. Catalog: ACM114080932. | |
| Isoxazolo[5,4-e]indolizine(9ci) | Heterocyclic Organic Compound. CAS No. 110799-54-7. Catalog: ACM110799547. | |
| Ispronicline | Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults. Group: Agonists. Alternative Names: Ispronicline; AZD3480; AZD-3480; AZD 3480; TC 1734; TC-01734; TC1734; TC01734; TC 1734; TC 01734; RJR 1734; RJR-1734; RJR1734. CAS No. 252870-53-4. Molecular formula: C14H22N2O. Mole weight: 234.34. Appearance: Oily liquid. Purity: >98%. IUPACName: (S,E)-5-(5-isopropoxypyridin-3-yl)-N-methylpent-4-en-2-amine. Canonical SMILES: C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1. Catalog: ACM252870534. | |
| ITIC-Cl | ITCI-CI is a low band acceptor-donor-acceptor molecule with indacenodithieno[3,2-b]thiophene (IT) as a central donor atom and 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile (IC) as an acceptor end group. It is also a non-fullerene electron acceptor with a push-pull structure that induces an intramolecular charge transfer and extends absorption. Uses: Itci-ci can be mainly used in the fabrication of polymeric solar cells with an efficiency that is less than 11% and excellent thermal stability. Group: N-type small molecules. Alternative Names: 3,9-bis(2-methylene-((3-(1,1-dicyanomethylene)-6,7-dichloro)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']dithiophene,ITIC-2Cl. CAS No. 2253663-81-7. Mole weight: 1565.72. Catalog: ACM2253663817. | |
| Itraconazole | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor. Group: Inhibitors. Alternative Names: 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one. CAS No. 84625-61-6. Molecular formula: C35H38Cl2N8O4. Mole weight: 705.63. Appearance: Off-white crystalline solid. Purity: 0.9981. Canonical SMILES: ClC1=C (C=CC (Cl) =C1) [C@@]2 (O[C@@H] (COC3=CC=C (N4CCN (C5=CC=C (N (C=NN6C (C) CC) C6=O) C=C5) CC4) C=C3) CO2) CN7C=NC=N7. Density: 1.4 g/cm³. ECNumber: 283-347-2. Catalog: ACM84625616. | |
| IUN78876 | IUN78876, also known as 7-benzyl-4-(2,4-difluorobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one is a chemical reagent for research use. Group: Others. Alternative Names: IUN78876; IUN-78876; IUN 78876. CAS No. 1638178-87-6. Molecular formula: C23H22F2N4O. Mole weight: 408.45. Appearance: Solid powder. Purity: >98%. IUPACName: 7-benzyl-4-(2,4-difluorobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one. Canonical SMILES: O=C1N (CC2=CC=C (F)C=C2F)C3=NCCN3C4=C1CN (CC5=CC=CC=C5)CC4. Catalog: ACM1638178876. | |
| Ivermectin B1a | Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310). Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19. Group: Inhibitors. Alternative Names: 5-O-Demethyl-22,23-dihydro-avermectin A1a. CAS No. 71827-03-7. Molecular formula: C48H74O14. Mole weight: 875.09. Appearance: White to off-white solid. Purity: 0.85. IUPACName: (1R, 4S, 5'S, 6R, 6'R, 8R, 10E, 12S, 13S, 14E, 16E, 20R, 21R, 24S)-6'-[(2S)-butan-2-yl]-21, 24-dihydroxy-12-[(2R, 4S, 5S, 6S)-5-[(2S, 4S, 5S, 6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5', 11, 13, 22-tetramethylspiro[3, 7, 19-trioxatetracyclo[15.6.1.14, 8.020, 24]pentacosa-10, 14, 16, 22-tetraene-6, 2'-oxane]-2-one. Canonical SMILES: CC[C@H] (C)[C@@H]1[C@H] (CC[C@@]2 (O1)C[C@@H]3C[C@H] (O2)C/C=C (/[C@H] ([C@H] (/C=C/C=C/4\CO[C@H]5[C@@]4 ([C@@H] (C=C ([C@H]5O)C)C (=O)O3)O)C)O[C@H]6C[C@@H] ([C@H] ([C@@H] (O6)C)O[C@H]7C[C@@H] ([C@H] ([C@@H] (O7)C)O)OC)OC)\C)C. Catalog: ACM71827037-1. | |
| Ivy Extract | Extract obtained from Hedera Helix (Ivy) leaves and stems. Contains 20% extract dissolved in water and glycerin. Has good soothing, anti-irritant and skin-softening properties. Uses: Creams, lotions, bath care products and after sun lotions. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84082-54-2 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0818. | |
| Iwr-1-exo | Heterocyclic Organic Compound. Alternative Names: IWR-1-exo; exo-IWR-1. CAS No. 1127442-87-8. Molecular formula: C25H19N3O3. Mole weight: C25H19N3O3. Purity: >99 %. IUPACName: CHEBI:62883. Catalog: ACM1127442878. | |
| IXA4 | IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 transiently activates protective IRE1/XBP1s signaling in liver without inducing RIDD or TRAF2/JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1-dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven metabolic dysfunction. Group: Inhibitors. Alternative Names: IXA4; IXA-4; IXA 4. CAS No. 1185329-96-7. Molecular formula: C24H28N4O4. Mole weight: 436.51. Appearance: Solid powder. Purity: >98%. IUPACName: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide. Canonical SMILES: CC1=CC=C (OCCN (C (CN2N=CC (NC (=O)CCOC3=CC=CC=C3)=C2)=O)C)C=C1. Catalog: ACM1185329967. | |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Group: Inhibitors. Alternative Names: IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. Appearance: Solid. Purity: 0.9984. Canonical SMILES: O=C ([C@@H] ([C@H] ([C@H] (CCC[C@]1 (O[C@]1 (C[C@H] (N2)/C (C)=C/C3=CSC (C)=N3)[H])C)C)O)C)C (C) ([C@H] (CC2=O)O)C. Catalog: ACM219989841. | |
| J51 | Band gap: 1.99 eV. Group: Organic field effect transistor (ofet) materialsorganic solar cell (opv) materials. Alternative Names: Poly[(5,6-difluoro-2-octyl-2H-benzotriazole-4,7-diyl)-2,5-thiophenediyl[4,8-bis[5-(2-hexyldecyl)-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]-2,5-thiophenediyl]. CAS No. 1393529-03-7. Molecular formula: (C72H93F2N3S6)n. Catalog: ACM1393529037. | |
| Jaborandi Extract | Extract obtained from Pilocarpus Pennatifloius (Jaborandi) leaves. Contains 20% extract dissolved in water and glycerin. Has invigorating, cooling and stimulating properties. Uses: Hair tonics and lotions, toners and bath products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84696-42-4 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0847. | |
| Jasplakinolide | Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity. Group: Inhibitors. Alternative Names: (3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone. CAS No. 102396-24-7. Molecular formula: C36H45BrN4O6. Mole weight: 709.7. Appearance: Solid. Purity: 95%+. IUPACName: (4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone. Canonical SMILES: CC1CC (OC (=O)CC (NC (=O)C (N (C (=O)C (NC (=O)C (CC (=C1)C)C)C)C)CC2=C (NC3=CC=CC=C32)Br)C4=CC=C (C=C4)O)C. Catalog: ACM102396247. | |
| Jatamanvaltrate B | Terpenoids. CAS No. 1134138-66-1. Molecular formula: C32H50O13. Mole weight: 642.73. Appearance: Oil. Purity: 0.98. IUPACName: [(1S,4aR,6S,7R,7aS)-6-acetyloxy-4a,7-dihydroxy-1-(3-methylbutanoyloxy)-7-(3-methylbutanoyloxymethyl)-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4-yl]methyl 3-methyl-2-(3-methylbutanoyloxy)butanoate. Canonical SMILES: CC (C)CC (=O)OCC1 (C (CC2 (C1C (OC=C2COC (=O)C (C (C)C)OC (=O)CC (C)C)OC (=O)CC (C)C)O)OC (=O)C)O. Catalog: ACM1134138661. | |
| Jatrorrhizine chloride | Jatrorrhizine chloride is a compound with hypoglycemic effects that has been isolated from the roots of the Chinese herb Jatropha curcas. It has been shown to have an optical sensor effect through its interaction with a specific receptor in the eye. The compound has also been shown to inhibit 3t3-l1 preadipocyte differentiation and promote apoptosis in these cells. Jatrorrhizine chloride can be used as a potential pharmacological agent for the treatment of obesity, diabetes, and cancer. Group: Other alkaloids. CAS No. 6681-15-8. Molecular formula: C20H20ClNO4. Mole weight: 373.83 g/mol. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)O)OC)OC. [Cl-]. Catalog: ACM6681158-1. | |
| Jatrorrhizine hydrochloride | Jatrorrhizine hydrochloride is a naturally occurring compound, which has been shown to have hypoglycemic effects and can be used for the treatment of skin cancer. It is an analogue of berberine that inhibits mitochondrial membrane potential, leading to cell death by inhibiting energy metabolism and causing chromatographic analysis. Jatrorrhizine hydrochloride also inhibits the synthesis of proteins required for glycolysis, including hexokinase 2 (HK2), phosphofructokinase 1 (PFK1), and pyruvate kinase M2 (PKM2). This drug is metabolized by esterases or glucuronidases to form benzalkonium chloride or ginsenoside RG3. This active form binds to penicillin-binding protein, which may lead to metabolic disorders such as hepatic steatosis. Group: Other alkaloids. CAS No. 2106804-01-5. Molecular formula: C20H20NO4·HCl. Mole weight: 374.84 g/mol. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)O)OC)OC. [Cl-]. Catalog: ACM2106804015. | |
| Jatrorrhizine iodide | Jatrorrhizine iodide is a natural compound that belongs to the group of polymerase chain inhibitors. Jatrorrhizine iodide is a competitive inhibitor of the enzyme DNA-dependent RNA polymerase, which prevents transcription and replication. Jatrorrhizine iodide has been shown to have hypoglycemic effects in 3T3-L1 preadipocytes, which may be due to its ability to inhibit glucose uptake into cells by binding to the glucose transporter GLUT4. It has also been shown that this drug can inhibit multidrug efflux pump activity in pharmacological agents, thereby increasing their effect. Group: Other alkaloids. CAS No. 1168-00-9. Molecular formula: C20H20INO4. Mole weight: 465.28 g/mol. Canonical SMILES: [I-]. COc1cc2c (CC[n+]3cc4c (OC)c (OC)ccc4cc23)cc1O. Catalog: ACM1168009. | |
| Jervine | Jervine is a natural drug that has been shown to have synergistic effects with other drugs, such as angiogenic processes and matrix effects. Jervine is an ester hydrochloride derived from the bark of the tree Jervisia japonica. It has been shown to have significant cytotoxicity against human leukemia cells HL-60 in vitro. The mechanism of action of jervine is not yet fully understood, but it may be due to the presence of nitrogen atoms or sesquiterpene lactones. Group: Other alkaloids. Alternative Names: (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.6 g/mol. Canonical SMILES: C[C@H]1C[C@@H]2[C@H] ([C@H] ([C@]3 (O2)CC[C@H]4[C@@H]5CC=C6C[C@H] (CC[C@@]6 ([C@H]5C (=O)C4=C3C)C)O)C)NC1. Catalog: ACM469590. | |
| Jesaconitine | Jesaconitine is a natural compound that has been shown to have anti-inflammatory properties. It has been shown to inhibit the activity of cyclooxygenase and lipoxygenase enzymes, which are involved in the production of prostaglandins. Jesaconitine also inhibits the expression of nuclear DNA and suppresses myeloma cells by inhibiting their ability to synthesize proteins. Jesaconitine has also been shown to inhibit chronic arthritis in animal models by suppressing inflammation and preventing joint damage. This compound is not active against nonsteroidal anti-inflammatory drugs such as ibuprofen, diclofenac, and naproxen. Jesaconitine can be extracted from the plant Angelica Dahurica or synthesized in laboratories. It is soluble in trifluoroacetic acid (TFA) and can be analyzed using nuclear magnetic resonance spectroscopy with high values for matrix effect and control analysis. Group: Other alkaloids. Alternative Names: Diesaconitine(1a,3a,6a,14a,15a,16b)-20-Ethyl-1,6,16-triMethoxy-4-(MethoxyMethyl)-aconitane-3,8,13,14,15-pentol 8-Acetate 14-(4-Meth oxybenzoate). CAS No. 16298-90-1. Molecular formula: C35H49NO12. Mole weight: 675.76 g/mol. Canonical SMILES: CCN1C[C@@]2 ([C@@H] (C[C@@H] ([C@@]34[C@@H]2[C@H] ([C@@H] ([C@H]31)[C@@]5 ([C@@H]6[C@H]4C[C@@] ([C@@H]6OC (=O)C7=CC=C (C=C7)OC) ([C@H] ([C@@H]5O)OC)O)OC (=O)C)OC)OC)O)COC. Catalog: ACM16298901. | |
| Jfd00244 | JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2. Group: Inhibitors. CAS No. 96969-83-4. Molecular formula: C30H26N2O4. Mole weight: 478.54. Appearance: Solid. Purity: 0.9803. Canonical SMILES: O=C1C2=C (C=CC=C2)C (C3=C (NCCC4=CC=C (O)C=C4)C=CC (NCCC5=CC=C (O)C=C5)=C13)=O. Catalog: ACM96969834. | |
| JH-X-119-01 | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Group: Inhibitors. Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C (NC1=CC=C (NC (C2=CC=CC (NC (C=C)=O)=C2)=O)C=C1)C3=NC (C4=CC=NN4)=CC=C3. Catalog: ACM2227368547. | |
| JMS-17-2 | JMS-17-2 is a potent and selective antagonist of CX3CR1. Group: Antagonists. Alternative Names: JMS-17-2; JMS172; JMS 17 2; JMS17-2; JMS-172; JMS 17-2; JMS-17 2. CAS No. 1380392-05-1. Molecular formula: C25H26ClN3O. Mole weight: 419.95. Appearance: Solid powder. Purity: >98%. IUPACName: 5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one. Canonical SMILES: O=C1C2=CC=CN2C3=C (C=CC=C3)N1CCCN4CCC (C5=CC=C (Cl)C=C5)CC4. Catalog: ACM1380392051. | |
| JNJ-40411813 | JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ-40411813 acts as a PAM at the cloned mGlu2 receptor: EC50=147 ± 42 nmol/L in a [(35)S]GTPγS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50=64 ± 29 nmol/L in a Ca(2+) mobilization assay with hmGlu2 G α16 cotransfected HEK293 cells. JNJ-40411813 displaced [(3)H]JNJ-40068782 and [(3)H]JNJ-46281222 (mGlu2 receptor PAMs), while it failed to displace [(3)H]LY341495 (a competitive mGlu2/3 receptor antagonist). JNJ-40411813 is an interesting candidate to explore the therapeutic potential of mGlu2 PAMs, in in vivo rodents experiments as well as in clinical studies. Group: Others. Alternative Names: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. Appearance: Solid powder. Purity: >98%. IUPACName: 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone. Canonical SMILES: ClC1=C (N2CCC (C3=CC=CC=C3)CC2)C=CN (CCCC)C1=O. Catalog: ACM1127498036. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable. Group: Agonists. Alternative Names: JNJ 63533054; JNJ63533054; JNJ-63533054. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.79. Appearance: Solid powder. Purity: >98%. IUPACName: 3-Chloro-N-[2-oxo-2-[[ (1S) -1-phenylethyl]amino]ethyl]benzamide. Canonical SMILES: O=C (NCC (N[C@H] (C1=CC=CC=C1)C)=O)C2=CC=CC (Cl)=C2. Catalog: ACM1802326664. | |
| JNJ-63576253 | JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells. Group: Antagonists. Alternative Names: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253. CAS No. 2110426-27-0. Molecular formula: C23H21F3N6O2S. Mole weight: 502.52. Appearance: Solid powder. Purity: >98%. IUPACName: 5- (8-Oxo-5- (6- (piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5, 7-diazaspiro[3. 4]octan-7-yl)-3- (trifluoromethyl)-picolinonitrile. Canonical SMILES: N#CC1=NC=C (N (C2=O)C (N (C3=CC=C (OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C (F) (F)F. Catalog: ACM2110426270. | |
| Jojoba Castor Beads | Tiny, spherically shaped beads consisting of natural jojoba oil and castor oil, round shape warrants effective but gentle exfoliation, not animal tested. 40/60 mesh size, white/vanilla color, ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Facial scrubs, specialty bar soap, body washes, body scrubs, shower gels. Group: Sensory modifiers. CAS No. 92457-12-0/8001-78-3. Appearance: Small, round beads, faint odor. Catalog: CI-SC-0175. | |
| Jojoba Gel | Anhydrous transparent viscous gel consisting of jojoba oil (Simmondsia chinensis) combined with polymers (ethylene-propylene-styrene copolymer & ethylene-butylene-styrene copolymer). Uses: All kinds of emulsions (creams, lotions, cleansers, hair creams, makeup foundations), lip care products, massage oils, baby oils. Group: Skin actives. CAS No. 61789-91-1/66070-58-4/68648-89-5. Appearance: Viscous pale yellow fluid, odorless. Catalog: CI-SC-0726. | |
| Jojoba Meal Extract | Extract obtained from Simmondsia Chinensis (Jojoba) seeds. Contains 20% extract dissolved in water and glycerin. Has good moisturizing and soothing properties. Widely used to for blemished, irritated or sensitive skin. Uses: Creams and lotions, bath care products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 90045-98-0 / 122-99-6. Appearance: Light to medium yellow liquid, characteristic odor. Catalog: CI-SC-0903. | |
| Jojoba Pearls, Green | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/12001-99-9. Appearance: Small, round green beads, faint odor. Catalog: CI-SC-0261. | |
| Jojoba Pearls, Orange | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/2379-74-0/51274-00-1. Appearance: Small, round orange beads, faint odor. Catalog: CI-SC-0263. | |
| Jojoba Pearls, Red | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/2379-74-0. Appearance: Small, round red beads, faint odor. Catalog: CI-SC-0262. | |
| Jojoba Protein HP, Hydrolyzed | Hydrolyzed (fragmented) proteins enzymatically extracted from the jojoba plant, 100% natural, MW 1800-2400 kD. Precipitations of proteins in the bottom of the container is normal. Uses: Lotions, creams, sun care products & after sun products, hair shampoos, leave-in-conditioners, hair mousse, shower gels, makeup products (mascara, foundations). Group: Skin actives. CAS No. 100684-35-3 / 7732-18-5 / 122-99-6 / 24634-61-5. Appearance: Dark brown, cloudy, faint odor. Catalog: CI-SC-0582. | |
| Joro spider toxin(jstx-3) | Heterocyclic Organic Compound. Alternative Names: JSTX-3;JORO SPIDER TOXIN;JORO-SPIDER-TOXIN, [125I];JORO SPIDER TOXIN JSTX-3; N1- (5- (3- (3- (4-Aminobutylamino) propylamino) propanamido) pentyl) -2- (2- (2, 4-dihydroxyphenyl) acetamido) succinamide; (S) -N-[5-[[3-[[4-[ (3-Aminopropyl) amino]butyl]amino]propionyl]amino]. CAS No. 112163-33-4. Molecular formula: C27H47N7O6. Mole weight: 565.71. Appearance: Off-white lyophilized solid. Catalog: ACM112163334. | |
| Josamycin | A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. Alternative Names: Iosalide;Vilprafen;Leucomycin A3;EN 141. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 827.99. Appearance: light yellow powder. Purity: 0.98. IUPACName: josamycin. Density: 1.2 g/cm³. ECNumber: 240-871-6. Catalog: ACM16846245. | |
| JQKD82 HCl | JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50=0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently. Group: Inhibitors. Alternative Names: JQKD82 HCl; JQKD82 hydrochloride; JQKD82; JQKD-82; JQKD 82; PCK82; PCK-82; PCK 82. CAS No. 2410512-38-6. Molecular formula: C27H43Cl3N4O5. Mole weight: 610.01. Appearance: Solid powder. Purity: >98%. IUPACName: 2,4-diisopropoxyphenyl 2- ( ( (2- ( (2- (dimethylamino) ethyl) (ethyl) amino) -2-oxoethyl) amino) methyl) isonicotinate trihydrochloride. Canonical SMILES: O=C (OC1=CC=C (OC (C)C)C=C1OC (C)C)C2=CC=NC (CNCC (N (CCN (C)C)CC)=O)=C2. [H]Cl. [H]Cl. [H]Cl. Catalog: ACM2410512386. | |
| JTE-607 HCl | JTE-607, also known as TO-207, is a cytokine production inhibitor potentially for the treatment of systemic inflammatory response, and induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Group: Inhibitors. Alternative Names: TO-207; TO 207; TO207; JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride. CAS No. 188791-09-5. Molecular formula: C25H33Cl4N3O5. Mole weight: 597.36. Appearance: Solid powder. Purity: >98%. IUPACName: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Canonical SMILES: O=C (OCC)[C@H] (CC1=CC=CC=C1)NC (C2=CC (Cl)=C (OCCN3CCN (C)CC3)C (Cl)=C2O)=O. [H]Cl. [H]Cl. Catalog: ACM188791095. | |
| Juniper Extract | Extract obtained from Juniperus Communis (Juniper) fruits. Contains 20% extract dissolved in water and glycerin. Has soothing, anti-irritant and calming properties. Uses: Creams, lotions and bath products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84603-69-0 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0832. | |
| JX-06 | JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme. Group: Inhibitors. Alternative Names: JX-06; JX 06; JX06. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.49. Appearance: Solid powder. Purity: >98%. IUPACName: Bis(morpholinothiocarbonyl) disulfide. Canonical SMILES: S=C(SSC(N1CCOCC1)=S)N2CCOCC2. Catalog: ACM729464. | |
| JYN42346 | JYN42346, also known as Complement factor D-IN-2, is an inhibitor of complement factor D. JYN42346 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. JYN42346 can be used for the research of autoimmune diseases. JYN42346 was first reported in patent WO2015130838A1 (compound 190). Group: Inhibitors. Alternative Names: Complement factor D-IN-2; JYN42346; JYN 42346; JYN-42346. CAS No. 1903742-34-6. Molecular formula: C27H24BrN7O3. Mole weight: 574.44. Appearance: Solid powder. Purity: >98%. IUPACName: (1R,3S,5R)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide. Canonical SMILES: O=C ([C@H]1N (C (CN2N=C (C (C)=O)C3=C2C=CC (C4=CN=C (C)N=C4)=C3)=O)[C@]5 ([H])C[C@]5 ([H])C1)NC6=NC (Br)=CC=C6. Catalog: ACM1903742346. | |
| K19 Dye | K19 Dye is an amphiphilic ruthenium sensitizer with a good molar extinction coefficient, which remains stable under thermal stress and light soaking. It can be synthesized by forming a reaction mixture of 4,4'-Bis(p-hexyloxystyryl)-2,2'-bipyridine, dichloro(p-cymene)ruthenium(II) dimer, and 4,4'-dicarboxylic acid-2,2'-bipyridine. It shows an overall power conversion efficiency (PCE) of 11% and can be used as an active material in electrochemical applications.]. Uses: Electron transfer from k-19 dye to the conduction band of titania is completed within 20 fs while charge recombination has a half-life of 800 μs. the high extinction coefficient of this sensitizer enable realization of a new generation thin-film dye-sensitized solar cells (dscs) yielding high conversion efficiency at full sunlight, even with viscous electrolytes based on ionic liqs. or nonvolatile solvents, making solar cell devices exhibit excellent stability under light soaking. Group: Dye sensitizers. Alternative Names: Ru(4,4-dicarboxylic acid-2,2 inverted exclamation marka-bipyridine)(4,4 inverted exclamation marka-bis(p-hexyloxystyryl)-2,2-bipyridine)(NCS)2. CAS No. 847665-45-6. Molecular formula: C52H52N6O6RuS2. Mole weight: 1022.21. Appearance: Black powder. Canonical SMILES: CCCCCCOC1=CC=C (C=C1)C=CC2=CC (=NC=C2)C3=NC=CC (=C3)C=CC4=CC=C (C=C4)OCCCCCC. C1=CN=C (C=C1C (=O)O)C2=NC=CC (=C2)C (=O)O. C (=[N-])=S. C (=[N-])=S. [Ru+2]. Catalog: ACM847665456-1. | |
| k-252a | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. Group: Inhibitors. CAS No. 99533-80-9. Molecular formula: C27H21N3O5. Mole weight: 467.47. Purity: >98 %. Catalog: ACM99533809. | |
| Kaempferide | Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins. Kaempferide has antiviral activities. Group: Inhibitors. CAS No. 491-54-3. Molecular formula: C16H12O6. Mole weight: 300.26. Appearance: Solid. Purity: 0.99. Canonical SMILES: O=C1C (O)=C (C2=CC=C (OC)C=C2)OC3=CC (O)=CC (O)=C13. Catalog: ACM491543. | |
| Kaempferol | Kaempferol is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276 - 278°C (529 - 532°F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol acts as an Antioxidants by reducing oxidative stress. Many studies suggest that consuming kaempferol may reduce the risk of various cancers, and it is currently under consideration as a possible cancer treatment. Group: Inhibitors. Alternative Names: 5,7,4'-Trihydroxyflavonol. CAS No. 520-18-3. Molecular formula: C15H10O6. Mole weight: 286.24. Appearance: Yellow powder. Purity: 0.98. IUPACName: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)chromen-4-one. Canonical SMILES: C1=CC (=CC=C1C2=C (C (=O)C3=C (C=C (C=C3O2)O)O)O)O. Density: 1.2981 g/cm³. ECNumber: 208-287-6. Catalog: ACM520183. | |
| Kaempferol 3,4'-Diglucoside 7-Rhamnoside | Flavonoids. CAS No. 1131009-93-2. Molecular formula: C33H40O20. Mole weight: 756.7. Appearance: Light beige-yellow powder. Purity: 0.98. IUPACName: 5-hydroxy-3-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[4-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one. Canonical SMILES: CC1C (C (C (C (O1)OC2=CC (=C3C (=C2)OC (=C (C3=O)OC4C (C (C (C (O4)CO)O)O)O)C5=CC=C (C=C5)OC6C (C (C (C (O6)CO)O)O)O)O)O)O)O. Catalog: ACM1131009932. | |
| Kaempferol-3-O-(6'''-Trans-P-Coumaroyl-2''-Glucosyl)Rhamnoside | Phenols. CAS No. 111957-48-3. Molecular formula: C36H36O17. Mole weight: 740.66. Catalog: ACM111957483. | |
| Kaempferol 3-Robinoside 7-Glucoside | Flavonoids. CAS No. 114924-89-9. Molecular formula: C33H40O20. Mole weight: 756.7. Appearance: Yellow powder. Purity: 0.98. Catalog: ACM114924899. | |
| Kakadu Plum Extract | Australian Fruit also called Gubinge, Billygoat or Murunga. Kakadu plumb contains the highest concentration of Vitamin C of most fruits (about 100 times higher than oranges). It has been used in food & medicine for hundreds of years. Uses: Anti-aging serums, creams & lotions, sun care and after-sun care, sunscreens, face & hair masks. Group: Skin actives. CAS No. 56-81-5/7732-18-5/1176234-54-0. Appearance: Clear to slightly cloudy, pale yellow, slight sweet plum odor. Catalog: CI-SC-0653. | |
| Kali Musli Extract | Extract obtained from Curculigo Orchioides (Kali Musli) roots. Ideal active ingredient for the improvement of sensitive skin. Through the regulation of the NHE1 protein, it acts on the internal control mechanism of skin pH, repairing the barrier function and causing a decrease in skin reactivity and sensitivity. Uses: Cosmetic applications include make up, shaving ranges, intimate hygiene, products for babies and hair care for sensitive scalps. Group: Skin actives. CAS No. 504-63-2/56-81-5/7732-18-5. Catalog: CI-SC-0634. | |
| Kanshone A | Terpenoids. Alternative Names: (-)-Kanshone. CAS No. 115356-18-8. Molecular formula: C15H22O2. Mole weight: 234.33. Appearance: Powder. Purity: 0.98. IUPACName: (4R,4aR,5R)-4-(2-hydroxypropan-2-yl)-4a,5-dimethyl-4,5,6,7-tetrahydronaphthalen-1-one. Canonical SMILES: CC1CCC=C2C1(C(C=CC2=O)C(C)(C)O)C. Density: 1.05±0.1 g/cm3(Predicted). Catalog: ACM115356188. | |
| Kanshone B | Terpenoids. Alternative Names: 5H-Naphtho[2,1-C][1,2]Dioxol-5-One,1,3A,4,7,8,9,9A,9B-Octahydro-7-Hydroxy-1,1,9,9A-Tetramethyl-,(3Ar,7R,9R,9Ar,9Bs)-. CAS No. 115370-61-1. Molecular formula: C15H22O4. Mole weight: 266.33. Appearance: Powder. Purity: 0.98. IUPACName: (3aR,7R,9R,9aR,9bS)-7-hydroxy-1,1,9,9a-tetramethyl-3a,4,7,8,9,9b-hexahydronaphtho[2,1-c]dioxol-5-one. Canonical SMILES: CC1CC(C=C2C1(C3C(CC2=O)OOC3(C)C)C)O. Density: 1.19±0.1 g/cm3(Predicted). Catalog: ACM115370611. | |
| Karakanine | Karakanine is a diterpenoid alkaloid that has been used in Chinese medicine for the treatment of diabetes. It inhibits glycogen synthesis and increases blood glucose levels by blocking the production of insulin. Karakanine also possesses anti-diabetic properties, as it is able to inhibit the synthesis of cholesterol. Karakanine can be extracted from plants such as Acorus calamus, Rhizoma coptidis, and Rhizoma zingiberis. This compound can be identified using analytical methods such as nuclear magnetic resonance spectroscopy that reveal its chemical structure. Group: Other alkaloids. CAS No. 50656-90-1. Molecular formula: C22H33NO4. Mole weight: 375.5 g/mol. Catalog: ACM50656901. | |
| KB-0742 HCl | KB-0742 is an orally bioavailable, selective CDK9 inhibitor with potent anti-tumor activity in CRPC models. In 22Rv1 cells, KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs. In vivo, oral administration of KB-0742 significantly reduced tumor growth in CRPC, supporting CDK9 inhibition as a promising therapeutic strategy to target AR dependence in CRPC. Group: Inhibitors. Alternative Names: KB-0742; KB0742; KB 0742 2HCl; KB 0742 dihydrochloride; KB 0742 hydrochloride. CAS No. 2416874-75-2. Molecular formula: C16H27Cl2N5. Mole weight: 360.33. Appearance: Solid powder. Purity: >98%. IUPACName: (1S,3S)-N1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine dihydrochloride. Canonical SMILES: CCC (CC)C1=NC2=CC=NN2C (N[C@@H]3C[C@@H] (N)CC3)=C1. Cl. Cl. Catalog: ACM2416874752. | |
| Kb-r7943 mesylate | KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux. Group: Inhibitors. CAS No. 182004-65-5. Molecular formula: C16H17N3O3S.CH3SO3H. Mole weight: 427.5. Appearance: Solid. Purity: >99 %. Canonical SMILES: NC (SCCC1=CC=C (OCC2=CC=C ([N+] ([O-])=O)C=C2)C=C1)=N. CS (=O) (O)=O. Catalog: ACM182004655. | |
| KC01 | KC01 is a covalent inhibitor of ABHD16A. ABHD16A is a phosphatidylserine (PS) lipase that generates lyso-PS in mammalian systems. KC01 can deplete lysoPSs from cells, including lymphoblasts derived from subjects with PHARC. Group: Inhibitors. Alternative Names: KC01; K C01; K-C01. CAS No. 1646795-59-6. Molecular formula: C22H39NO3. Mole weight: 365.56. Appearance: Solid powder. Purity: >98%. IUPACName: (Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide. Canonical SMILES: O=C (N)CCCC/C=C1C (OC\1CCCCCCCCCCCCC)=O. Catalog: ACM1646795596. | |
| Kelp Extract, USDA Certified Organic | Organic Marine kelp (brown algae) extract dissolved in water and an organic rice solution. Preserved with Leuconostoc Ferment Filtrate. Uses: Nourishing and anti-aging serums, creams & lotions, sun- and after-sun care, sunscreens, night creams. Group: Skin actives. CAS No. 68553-81-1 / 7732-18-5 / 84775-78-0 / 68333-16-4 / 9054-89-1 / 9003-99-0. Appearance: Clear to hazy yellow to amber liquid, characteristic odor. Catalog: CI-SC-0743. | |
| Keratin | Keratin is a fibrous protein that comprises the majority of the structure of hair, nails, and the outer layer of the skin in mammals. It is a very strong and durable protein that provides essential mechanical strength and protective functions to these structures. In hair, keratin helps to give it its strength, flexibility, and elasticity. In nails, it provides the hardness and durability needed to protect them from damage. In the skin, it helps to form a barrier against harmful substances and pathogens. Keratin is produced by special cells called keratinocytes, which are found in the outer layer of the skin and in the hair follicles. Uses: 1. hair care products: keratin is widely used in hair care products like shampoos, conditioners, and hair serums. it helps in repairing damaged hair by strengthening hair fibers, smoothing the hair cuticle, and adding shine to dull hair. 2. skin care products: keratin is also used in skin care products like moisturizers, creams, and lotions. it helps in improving skin elasticity by promoting colla. Group: Hair actives. CAS No. 68238-35-7. Appearance: Keratin is a fibrous protein that appears as long, slender, and cylindrical strands. Catalog: CI-HC-0228. | |
| Keratin Protein, Hydrolyzed | Sheep-wool derived, hydrolyzed alpha-keratin protein carefully monitored during its manufacture to ensure the lowest possible odor and a low ash. Keratin is a highly specialized fibrous protein, which is found in hair, feathers, wool and nails. Keratin is distinct from other proteins in that it is rich in cysteine (a sulfur-containing amino acid) giving keratin a unique strength and protective quality. Derived from sheep's wool. Contains 20-23% of protein. Molecular weight: 1,100-3,300 Da. Gluten-free. Uses: All kinds of hair care products including shampoos, hair conditioners, hair balms, hair pomades and also skin care products including lotions and creams. Group: Cationic surfactants & conditioning agents. CAS No. 69430-36-0. Appearance: Clear amber liquid, characteristic odor. Catalog: CI-HC-0063. | |
| Ketoconazole | Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. Group: Inhibitors. Alternative Names: rel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine. CAS No. 65277-42-1. Molecular formula: C26H28Cl2N4O4. Mole weight: 531.43. Appearance: White solid. Purity: 0.98. Catalog: ACM65277421. | |
| Ketodarolutamide | Ketodarolutamide., also known as ORM-15341 and BAY-1896953, is a potent and full antagonist for human AR (hAR) with IC50=38 nM. Ketodarolutamide is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of darolutamide (ODM-201, BAY-1841788), an NSAA which is used in the treatment of prostate cancer in men. Similarly to its parent compound, darolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives. Group: Antagonists. Alternative Names: BAY-1896953; BAY 1896953; BAY1896953; ORM-15341; ORM 15341; ORM15341; Ketodarolutamide. CAS No. 1297537-33-7. Molecular formula: C19H17ClN6O2. Mole weight: 396.84. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide. Canonical SMILES: ClC1=C (C#N)C=CC (C2=NN (C[C@H] (C)NC (C3=NNC (C (C)=O)=C3)=O)C=C2)=C1. Catalog: ACM1297537337. | |
| Keto itraconazole | Heterocyclic Organic Compound. Alternative Names: KETO ITRACONAZOLE;keto-ITZ;rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methyl-2-oxopropyl)-3H-1,2,4-triazol-3-one. CAS No. 112560-33-5. Molecular formula: C35H36Cl2N8O5. Mole weight: 719.62. Appearance: Off-White Solid. Catalog: ACM112560335. | |
| Ketoprofen-13C,d3 | Ketoprofen-13C,d3 is 13C- and deuterium-labeled ketoprofen. Ketoprofen is a chemical that has analgesic, anti-inflammatory and antipyretic properties. The anti-inflammatory effect is stronger than that of ibuprofen, with fewer side effects and lower toxicity. Group: Isotope-labeled synthetic intermediates. Alternative Names: RP-19583-13C,d3. CAS No. 1189508-77-7. Molecular formula: C1513CH11D3O3. Mole weight: 258.29. Canonical SMILES: O=C (C1=CC=CC=C1)C2=CC (C ([13C] ([2H]) ([2H])[2H])C (O)=O)=CC=C2. Catalog: ACM1189508777. | |
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