Alfa Chemistry is an ISO 9001:2015 Certified Supplier of various building blocks, reagents, catalysts, nanomaterials, reference materials, and research chemicals. In-stock products can be shipped quickly.
×
Product
Description
Suppliers Website
Glycol Stearate IP
Self-emulsifying pearlizing and opacifying agent. Off-white flakes, faint odor. HLB value 5-6, gives water-in-oil emulsions. Melting Point: 57-60°C (135-140°F). Uses: Hair shampoos, conditioners, hair rinses, body washes, liquid soaps, lotions, creams, hair pastes, liquid soap. Group: Opacifiers & pearlizing agents. CAS No. 111-60-4/36284-86-3. Appearance: White to cream flakes. Catalog: CI-HC-0041.
Glycoproteins
Aqueous solution of a combination of mainly intracellular proteins, peptides and amino acids derived from a natural, specially-selected strain of yeast (saccharomyces cerevisiae). Contains 1-5% of glycoproteins. Uses: Moisturizers, creams, lotions, gels and color cosmetics. Group: Skin actives. Alternative Names: Proteins, polysaccharide complexes. CAS No. 66455-27-4/56-86-0/72-18-4/72-19-5. Appearance: Clear yellowish solution, faint odor. Catalog: CI-SC-0575.
Glyphosate is a herbicide that can be used as a selection agent in plant cells containing the EPSP sythetase gene. Uses: Glyphosate is a potent plant growth regulator and herbicide. its mode of action is to interfere with the shikimate pathway by inhibiting the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase, which is responsible for the biosynthesis of the aromatic compounds (e.g. tryptophan, phenylalanine, and tyrosine) and the 3-deoxy-d-arabino-heptulosonate 7-phosphate (dahp) synthase isozyme. Group: Other pgrs. Alternative Names: N-(Phosphonomethyl)glycine. CAS No. 1071-83-6. Molecular formula: C3H8NO5P. Mole weight: 169.07 g/mol. Appearance: White to Off-White Powder. Catalog: ACM1071836.
GNE-477
GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki=21 nM). Group: Inhibitors. Alternative Names: GNE-477; GNE477; GNE 477. CAS No. 1032754-81-6. Molecular formula: C21H28N8O3S2. Mole weight: 504.63. Appearance: Solid powder. Purity: >98%. IUPACName: 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine. Canonical SMILES: NC1=NC=C (C2=NC (N3CCOCC3)=C4C (C (C)=C (CN5CCN (S (=O) (C)=O)CC5)S4)=N2)C=N1. Catalog: ACM1032754816.
GNE-781
GNE-781 is a Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). GNE-781 showed TR-FRET IC50=0.94 nM, BRET IC50=6.2 nM, BRD4(1) IC50=5,100 nΜ) that maintained good in vivo PK properties in multiple species. GNE-781 displays anti-tumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner. Group: Inhibitors. Alternative Names: GNE-781; GNE 781; GNE781. CAS No. 1936422-33-1. Molecular formula: C27H33F2N7O2. Mole weight: 525.6. Appearance: Solid powder. Purity: >98%. IUPACName: 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide. Canonical SMILES: O=C (N1CCC (N (C2CCOCC2)N=C3N4CCCC5=C4C=C (C (F)F)C (C6=CN (C)N=C6)=C5)=C3C1)NC. Catalog: ACM1936422331.
Gnetol
Gnetol is a phenolic compound isolated from the root of Gnetum montanum. Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities. Group: Inhibitors. Alternative Names: 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Gnetol. CAS No. 86361-55-9. Molecular formula: C14H12O4. Mole weight: 244.2. Appearance: Powder. Purity: 0.98. IUPACName: 2-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol. Canonical SMILES: C1=CC (=C (C (=C1)O)C=CC2=CC (=CC (=C2)O)O)O. Catalog: ACM86361559.
GNF2133 HCl
GNF2133 is a potent and selective DYRK1A inhibitor (IC50 = 6 nM). In vitro, GNF2133 is able to proliferate both rodent and human β-cells. In vivo, GNF2133 demonstrated significant dose-dependent glucose disposal capacity and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in rat insulin promoter and diphtheria toxin A (RIP-DTA) mice. Group: Inhibitors. Alternative Names: GNF2133 HCl; GNF2133 hydrochloride; GNF2133; GNF-2133; GNF 2133. CAS No. 2561414-57-9. Molecular formula: C24H31ClN6O2. Mole weight: 471. Appearance: Solid powder. Purity: >98%. IUPACName: 4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide hydrochloride. Canonical SMILES: O=C (N1CCN (CC)CC1)NC2=NC=CC (C3=CN (C4CCOCC4)C5=C3C=CN=C5)=C2. [H]Cl. Catalog: ACM2561414579.
GO-6976
GO 6976, also known as PD-406976, is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. Gö 6976 blocked neurotrophin-induced signaling and autophosphorylation of neurotrophin-specific tyrosine kinase (Trk) receptors, either Trk B in cortical neurons or Trk A in GT1-1-trk9 cells. Group: Inhibitors. Alternative Names: GO6976; GO-6976; GO 6976; PD406976; PD 406976; PD-406976. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.44. Appearance: White solid powder. Purity: >98%. IUPACName: 3-(13-methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile. Canonical SMILES: N#CCCN (C1=C2C (CNC3=O)=C3C4=C1N (C)C5=C4C=CC=C5)C6=C2C=CC=C6. Catalog: ACM136194779.
Goji Berry Extract
Goji Berry (wolfberry) extract comes from the fruits of Lycium Barbarum L., which grows in the valleys of the Himalayas and Mongolia. Goji contains high percentages of macronutrients including carbohydrates (galactose, glucose, rhamnose, arabinose, mannose and xylose, between 30-40%), proteins (12%), fat, fiber (10%) and glycoconjugates. Uses: Anti-aging and toning skin care products, hair color protection formulas. Group: Skin actives. CAS No. 50463-2 / 7732-18-5 / 85085-46-7 / 532-32-1 / 24634-61-5. Appearance: Pale brown, transparent liquid. Catalog: CI-SC-0644.
Goldenseal Extract
Goldenseal root also known as yellow root or Indian turmeric. Contains 20% extract dissolved in water and glycerin. Uses: Anti-aging formulas, sun care and after-sun care products, makeup-up, and hair care products. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84603-60-1 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0670.
Gold(III) chloride
Gold(III) chloride, traditionally called auric chloride, is a chemical compound of gold and chlorine. With the molecular formula AuCl3, the name gold trichloride is a simplification, referring to the empirical formula. The Roman numerals in the name indicate that the gold has an oxidation state of +3, which is common for gold compounds. There is also another related chloride of gold, gold(I) chloride (AuCl). Chloroauric acid, HAuCl4, the product formed when gold dissolves in aqua regia, is sometimes referred to as gold chloride or acid gold trichloride. Gold(III) chloride is very hygroscopic and highly soluble in water as well as ethanol. It decomposes above 160°C or in light. Group: Metal & ceramic materials. Alternative Names: Trichlorogold;Gold(III) Chloride. CAS No. 13453-07-1. Molecular formula: AuCl3. Mole weight: 303.33. Appearance: Dark red monoclinic crystals. Density: 3.9 g/mL at 25ºC. ECNumber: 236-623-1. Catalog: ACM13453071.
Golgicide A
Golgicide A is a Potent, selective and reversible inhibitor of GBF1 ArfGEF. Golgicide A inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired incoming virus transport to the nuclear periphery. Inhibition of GBF1 via golgicide A can result in rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network. Group: Inhibitors. Alternative Names: Golgicide A; GCA. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.31. Appearance: Solid powder. Purity: >98%. IUPACName: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline. Canonical SMILES: FC4=CC ([C@]3 ([H])[C@] ([H])2CC=C3)=C (C (F)=C4)NC2C1=CN=CC=C1. Catalog: ACM1139889932.
Gomisin G
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively. Group: Inhibitors. Alternative Names: Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-7,8-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 8-benzoate, (6S,7S,8S,13aS)-. CAS No. 62956-48-3. Molecular formula: C30H32O9. Mole weight: 536.6. Appearance: White powder. Purity: 0.98. Canonical SMILES: CC1CC2=CC (=C (C (=C2C3=C (C4=C (C=C3C (C1 (C)O)OC (=O)C5=CC=CC=C5)OCO4)OC)OC)OC)OC. Density: 1.33±0.1 g/ml. Catalog: ACM62956483.
Goniodomin a
Heterocyclic Organic Compound. CAS No. 112923-40-7. Catalog: ACM112923407.
Extract obtained from the leaves of the Gotu Kola plant (Centella Asiatica) dissolved in a base of glycerin and water. Gotu Kola contains pentacyclic triterpenoids, including asiaticoside, brahmoside, asiatic acid, and brahmic acid (madecassic acid) and is used in products for irritated and sensitive skin. Uses: Serums, creams & lotions, skin cleansers, sun- and after-sun care, sunscreens, face & hair masks. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84776-24-9 / 84696-21-9 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0682.
g-pen-g-r-g-D-s-p-c-a
Heterocyclic Organic Compound. Alternative Names: G-PEN-G-R-G-D-S-P-C-A;GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA;gly-pen-gly-arg-gly-asp-ser-pro-cys-ala (pen2,cys. CAS No. 111844-17-8. Molecular formula: C35H57N13O14S2. Mole weight: 948.04. Catalog: ACM111844178.
(+/-)-GR24
Synthetic strigolactone analogue that has been shown to inhibit lateral shoot branching, stimulate germination of Striga, and aid in the symbiosis of more than 80% of terrestrial plants with fungi at arbuscular mycorrihizae in roots. Uses: Strigolactones are a class of compounds derived from carotenoids that have recently been shown to inhibit lateral, secondary shoot branching and thus play a role in apical dominance. (+/-)-gr24 is a potent synthetic analogue of strigolactones that has been directly used in many of the founding studies. transported from the root to the shoot, strigolactone hydrolysis leads to ubiquitination and destruction of d53, a protein necessary for axillary shoot development. it has been used to inhibit shoot branching in various plant species at concentrations of 0.15-1.5 mg/l. Group: Other pgrs. Alternative Names: (rac)-GR24; [(±)-(3aR*,8bS*,E)-3-(((R*)-4-methyl-5-oxo-2,5-dihydrofuran-2-yloxy)methylene)-3,3a,4,8b-tetrahydro2H-indeno[1,2-b]furan-2-one]. CAS No. 76974-79-3. Molecular formula: C17H14O5. Mole weight: 298.29 g/mol. Appearance: White powder. Catalog: ACM76974793.
Gramicidin
Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Group: Inhibitors. Alternative Names: GRAMACIDIN D;GRAMICIDIN;GRAMICIDIN D;GRAMICIDIN D [DUBOS];gramicidin from bacillus brevis*(gramicidin D);Gramicidin micronized USP23;GramicidinN.F.Xiv;gramicidin from bacillus aneurinolyticus (bacillus brevis). CAS No. 1405-97-6. Molecular formula: C99H140N20O17. Appearance: Solid. Purity: ≥98.0%. Catalog: ACM1405976.
Gramicidin c
Gramicidin c. Alternative Names: GRAMICIDIN C;GRAMICIDIN S;HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH;Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-);Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-);Gramicidin S1;Gramicidin S-A;Soviet Gramicidin C. CAS No. 113-73-5. Molecular formula: C60H92N12O10. Mole weight: 1141.45. Purity: 0.95. IUPACName: gramicidin S. Density: 1.24g/cm³. Catalog: ACM113735.
Gramine
Gramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties. Group: Inhibitors. Alternative Names: N,N-Dimethyl-1H-indole-3-methylamine. CAS No. 87-52-5. Molecular formula: C11H14N2. Mole weight: 174.24. Appearance: Beige powder. Purity: 0.98. IUPACName: 1-(1H-Indol-3-yl)-N,N-dimethylmethanamine. Canonical SMILES: CN(C)CC1=CNC2=CC=CC=C21. Density: 1.0715 g/cm³. Catalog: ACM87525.
Grandlure
Heterocyclic Organic Compound. Alternative Names: Grandisol;Grandlure (complete);(1S)-1-Methyl-2β-(1-methylethenyl)-1β-cyclobutaneethanol. CAS No. 11104-05-5. Molecular formula: C10H20O.C10H18O.C10H16O. Mole weight: 462.754. Catalog: ACM11104055.
Grapefruit Extract
Extract obtained from Citrus Grandis (Grapefruit) fruits. Contains 20% extract dissolved in water and glycerin. Has purifying, cleansing , antioxidant and non-irritating properties. Note: not to be confused with Grapefruit Seed Extract! Does not have anti-bacterial properties. Uses: Creams, lotions, soaps, toners and moisturizers. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 90045-43-5 / 122-99-6. Appearance: Light yellow liquid, characteristic odor. Catalog: CI-SC-0900.
Grape Leaf Extract
Extract obtained from Vitis vinefera (Grape) leaves. The leaves produce excellent astringent and antioxidant activity. Grape leaf extract is very helpful to formulate cosmetic products for use in sebum secretion regulation, wound recovery and protection of skin and hair against oxidative processes. Uses: Sebum regulation creams and lotions, moisturizers, facial cleansers, oily skin products. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84929-27-1 / 532-32-1 / 24634-61-5. Catalog: CI-SC-0684.
Grape Seed Extract
Extract from grape seeds dissolved in a base of glycerin and water. Extract widely used for anti-irritant skin care products. Uses: Anti-aging and anti-irritant creams, lotions, gels and toners. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84929-27-1 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0683.
Grape Seed Oil
Natural oil pressed from the seeds of grapes (cold pressed), contains 60-76% linoleic acid, 12-25% oleic acid, 6-9% palmitic acid and 3-6% stearic acid, rich in various vitamins including vitamin A, D and E. Uses: Creams, lotions, creams for impure skin, skin toners, bath & massage oils, anti-aging products, hair care products, makeup products. Group: Heterocyclic organic compound. Alternative Names: Raw grapeseed oil. CAS No. 8024-22-4. Mole weight: 280.45. Appearance: Pale yellow to greenish liquid, faint odor. Purity: 0.99. Density: 0.915-0.923 g/mL at 20 °C(lit.). Catalog: ACM8024224.
Grassofermata
Grassofermata, also known as NAV-2729, is a selective ARF6 inhibitor (IC50 = 1.0 μM). Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model, confirming the functional relevance of this pathway and suggesting a therapeutic strategy for Gα-mediated diseases. Group: Inhibitors. Alternative Names: NAV-2729; NAV 2729; NAV2729; Grassofermata. CAS No. 419547-11-8. Molecular formula: C25H17ClN4O3. Mole weight: 456.89. Appearance: Solid powder. Purity: >98%. IUPACName: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one. Canonical SMILES: O=C1C=C (C2=CC=C ([N+] ([O-])=O)C=C2)NC3=C (C4=CC=C (Cl)C=C4)C (CC5=CC=CC=C5)=NN13. Catalog: ACM419547118.
Green light-emitting spiro-copolymer
Features: Soluble green light-emitting spiro-copolymer. High efficiency. Long lifetime, with further potential to improve. Saturated green color coordinates, with low operation voltage. Typical performance measured in standard device stack (ITO/PEDOT:PSS 20 nm/SPG-01T 80 nm/Ba 6 nm/Ag 150 nm): Max. efficiency: 11 Cd/A. V_on: 2.5 V. V at 100 cd/m2: 3.6 V. V at 1000 cd/m2: 6.0 V. Max. power eff.: 12 lm/W. External quantum eff.: 4.1%. CIE1931 at 100 cd/m2: (0.33, 0.59). DC lifetime at 100 cd/m2 at RT: >10k hrs. AC lifetime at 200 cd/m2 at RT: >5000 hrs. Group: Photoactive polymers. CAS No. 1430803-21-6. Catalog: ACM1430803216.
Green Tea Butter
Hydrogenated vegetable oils blended with finely grounded matcha green tea leaves resulting in a buttery soft consistency. Uses: Lotions, creams, butters, sun care & after sun products (1-10%), hair care (1-5%), ointments and balms 4-100%. Group: Emollients/oils/wax. CAS No. 8007-69-0/84650-60-2. Appearance: Soft, creamy butter, faint odor. Catalog: CI-SC-0478.
Green Tea Extract
Green tea extract made from evergreen leaves of a small Asian tree that is cultivated in different regions. Undeveloped leaves are harvested manually, steamed to prevent fermentation, and then pressed and dried. Contains 5% of extract dissolved in water & glycerin (50/50). Uses: Anti-aging formulas, sun care and after-sun care products, anti-cellulite treatments and hair care products. Group: Skin actives. CAS No. 56-81-5 / 7732-18-5 / 84650-60-2 / 24634-61-5 / 590-00-1 / 532-32-1. Appearance: Pale brown liquid, faint herbal odor. Catalog: CI-SC-0674.
Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug. Group: Inhibitors. CAS No. 126-07-8. Purity: 0.9905. Catalog: ACM126078.
Grosvenorine
Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii. Grosvenorine exhibits good antibacterial and antioxidant activities. Group: Inhibitors. Alternative Names: Momordica grosvenori lutein. CAS No. 156980-60-8. Molecular formula: C33H40O19. Mole weight: 740.66. Appearance: Powder. Purity: 0.98. IUPACName: 7-[(2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one. Canonical SMILES: C[C@H]1[C@@H] ([C@H] ([C@H] ([C@@H] (O1)OC2=C (OC3=CC (=CC (=C3C2=O)O)O[C@H]4[C@@H] ([C@@H] ([C@H] ([C@@H] (O4)C)O)O)O[C@H]5[C@@H] ([C@H] ([C@@H] ([C@H] (O5)CO)O)O)O)C6=CC=C (C=C6)O)O)O)O. Density: 1.74±0.1 g/ml. Catalog: ACM156980608.
GROWTH HORMONE RELEASING FACTOR 1-29*AMI DE, BOVINE
GS 0573 is an antiviral compound that has been studied for potential treatment of Feline herpesvirus 1 (FHV-1). Group: Others. Alternative Names: GS 0573; GS0573; GS-0573. CAS No. 113852-41-8. Molecular formula: C8H13N6O4P. Mole weight: 288.2. Appearance: Solid powder. Purity: >98%. IUPACName: ((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid. Canonical SMILES: O=P(O)(O)COCCN1C2=NC(N)=NC(N)=C2N=C1. Catalog: ACM113852418.
GSK-189254 free base
GSK-189254 is a potent and selective H3-receptor inverse agonist. It has subnanomolar affinity for the H3 receptor and selectivity of over 10,000x for H3 over other histamine receptor subtypes. Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs. Group: Agonists. Alternative Names: GSK189254; GSK-189254; GSK 189254; GSK-189254 free base. CAS No. 720690-73-3. Molecular formula: C21H25N3O2. Mole weight: 351.45. Appearance: solid powder. Purity: >98%. IUPACName: 6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)oxy)-N-methylnicotinamide. Canonical SMILES: O=C (NC)C1=CN=C (OC2=CC=C3CCN (C4CCC4)CCC3=C2)C=C1. Catalog: ACM720690733.
GSK-2033
GSK-2033 is a potent cell-active LXR antagonist (pIC50 = 7.5). It enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells and is cell permeable. Group: Antagonists. Alternative Names: GSK-2033; GSK2033; GSK 2033. CAS No. 1221277-90-2. Molecular formula: C29H28F3NO5S2. Mole weight: 591.66. Appearance: Solid powder. Purity: >98%. IUPACName: 2, 4, 6-Trimethyl-N-[[3'- (methylsulfonyl) [1, 1'-biphenyl]-4-yl]methyl]-N-[[5- (trifluoromethyl) -2-furanyl]methyl]benzenesulfonamide. Canonical SMILES: O=S (C1=C (C)C=C (C)C=C1C) (N (CC2=CC=C (C3=CC=CC (S (=O) (C)=O)=C3)C=C2)CC4=CC=C (C (F) (F)F)O4)=O. Catalog: ACM1221277902.
GSK2879552
GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival. Group: Inhibitors. Alternative Names: GSK2879552; GSK-2879552; GSK 2879552. CAS No. 1401966-69-5. Molecular formula: C23H28N2O2. Mole weight: 364.48. Appearance: Solid powder. Purity: >98%. IUPACName: 4- ( (4- ( ( ( (1R, 2S) -2-phenylcyclopropyl) amino) methyl) piperidin-1-yl) methyl) benzoic acid. Canonical SMILES: O=C (O)C1=CC=C (CN2CCC (CN[C@H]3[C@H] (C4=CC=CC=C4)C3)CC2)C=C1. Catalog: ACM1401966695.
GSK2982772
GSK2982772 is a potent and selective receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate for the Treatment of Inflammatory Diseases. GSK2982772 is, currently in phase 2a clinical studies for psoriasis, rheumatoid arthritis, and ulcerative colitis. GSK2982772 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking many TNF-dependent cellular responses. RIP1 has emerged as an important upstream kinase that has been shown to regulate inflammation through both scaffolding and kinase specific functions. Group: Inhibitors. Alternative Names: GSK2982772; GSK-2982772; GSK 2982772. CAS No. 1622848-92-3. Molecular formula: C20H19N5O3. Mole weight: 377.4. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide. Canonical SMILES: O=C (C1=NN=C (CC2=CC=CC=C2)N1)N[C@@H]3C (N (C)C4=CC=CC=C4OC3)=O. Catalog: ACM1622848923.
GSK461364 is a selective, reversible and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM. Group: Inhibitors. Alternative Names: 5-[6-[ (4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[ (1r)-1-[2- (trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide. CAS No. 929095-18-1. Molecular formula: C27H28N5O2F3S. Mole weight: 543.6. Appearance: White to Beige Powder. Purity: 0.96. Catalog: ACM929095181.
GSK5182
GSK5182 is a specific inverse agonist for estrogen-related receptor &gamma. Group: Agonists. Alternative Names: GSK5182; GSK 5182; GSK-5182. CAS No. 877387-37-6. Molecular formula: C27H31NO3. Mole weight: 417.55. Appearance: Solid powder. Purity: >98%. IUPACName: 4-[(Z)-1-[4-(2-dimethylaminoethoxy)phenyl]-5-hydroxy-2-phenylpent-1-enyl]phenol. Canonical SMILES: OC1=CC=C (/C (C2=CC=C (OCCN (C)C)C=C2)=C (C3=CC=CC=C3)\CCCO)C=C1. Catalog: ACM877387376.
GSK591
GSK591, also known as EPZ015866 and GSK3203591, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50=11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50=56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. (http://www.thesgc.org/chemical-probes/GSK59). Group: Others. Alternative Names: GSK591; GSK-591; GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591. CAS No. 1616391-87-7. Molecular formula: C22H28N4O2. Mole weight: 380.49. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-2-(cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide. Canonical SMILES: O=C (NC[C@H] (O)CN1CCC (C=CC=C2)=C2C1)C3=CC (NC4CCC4)=NC=C3. Catalog: ACM1616391877.
GSK-J4 free base
GSK-J4 is a cell permeable, potent and selective histone demethylase. GSK-J4 is a prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. GSK-J4 is used to probe the consequences of demethylation of H3K27me3. GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines, including pro-inflammatory tumour necrosis factor (TNF). Group: Others. Alternative Names: GSK-J4 free base; GSK-J-4; GSK-J 4; GSK-J4. CAS No. 1373423-53-0. Molecular formula: C24H27N5O2. Mole weight: 417.51. Appearance: Solid powder. Purity: >98%. IUPACName: ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate. Canonical SMILES: O=C (OCC)CCNC1=NC (C2=NC=CC=C2)=NC (N3CCC4=CC=CC=C4CC3)=C1. Catalog: ACM1373423530.
Guaiacol-13C6
Guaiacol-13C6 is the 13C labeled Guaiacol. Guaiacol is a toxic chemical that is irritating to the skin and mucous membranes. If it infects the eyes, it can cause serious damage. Skin contact can cause burning sensation, dermatitis and blisters. Oral administration can cause acute gastroenteritis, vomiting, and diarrhea, which can sometimes be bloody. Mainly used as pesticide, catechol, and used in spices, medicine and other fields. Group: Isotope-labeled synthetic intermediates. Alternative Names: 2-Methoxyphenol-13C6. CAS No. 202326-52-1. Molecular formula: C13C6H8O2. Mole weight: 130.09. Canonical SMILES: CO[13C]1=[13C] ([13CH]=[13CH][13CH]=[13CH]1)O. Catalog: ACM202326521.
Guaifenesin-d5
Guaifenesin-d5 is the deuterium labeled Guaifenesin. Guaifenesin is suitable for phlegm cough, chronic bronchitis, bronchiectasis and other diseases. Group: Isotope-labeled synthetic intermediates. CAS No. 1329563-41-8. Molecular formula: C10H9D5O4. Mole weight: 203.25. Canonical SMILES: O (C (C (C (O) ([2H])[2H]) (O)[2H]) ([2H])[2H])C1=C (OC)C=CC=C1. Catalog: ACM1329563418.
In addition to being used as intermediates for drugs and dyes, guanidine salts are often used as flame retardants for cellulose matrix materials, such as wood, paper, and cardboard. Uses: Ionic liquids, chemical intermediates. Group: Functionized ionic liquids. Alternative Names: Diguanidiunium carbonate, Guanidinium carbonate. CAS No. 593-85-1. Molecular formula: C2H7N3O3. Mole weight: 180.17. Appearance: Crystalline Powder. Purity: ≥ 99.5%. Canonical SMILES: C(=N)(N)N.C(=N)(N)N.C(=O)(O)O. Catalog: ACM593851.
guanidine HydroIodide
Extremely hygroscopic. Handle in glove box. Handle and store under nitrogen atmosphere Guanidinium iodide (GI), a guanidinium compound, exhibits good piezoelectric and pyroelectric properties. It can be used in the fabrication of dye-sensitized solar cells (DSSCs). Group: Iodide salts. Alternative Names: gAI; guanidinium Iodide. CAS No. 19227-70-4. Molecular formula: CH5N3 HI. Mole weight: 186.98 g/mol. Appearance: White to Almost white powder to crystal. Purity: >97.0%(T). IUPACName: guanidine;hydroiodide. Canonical SMILES: C(=N)(N)N.I. Catalog: ACM19227704-1.
Guanidine Thiocyanate
Guanidinium thiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used in the extraction of DNA and RNA.Note: this compound may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation, [CH6N3]+.Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 Spanish flu, so that it can be studied safely. This application is presumably based on its denaturation activity.Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them. These enzymes would otherwise damage the extract.A commonly used method is guanidinium thiocyanate-phenol-chloroform extraction. It is not strictly necessary to use phenol or chloroform if extracting RNA for Northern blotting or DNA for Southern blot analysis because the gel electrophoresis followed by transfer to a membrane will separate the RNA/DNA from the proteins. Additionally, since these methods use probes to bind to their conjugates, peptides that get through the process dont generally matter unless a peptide is an RNase or DNase, and then only if the enzyme manages to renature, which should not occur if p
Guanosine
Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. Group: Inhibitors. Alternative Names: Guanine-9-β-D-ribofuranoside. CAS No. 118-00-3. Molecular formula: C10H13N5O5. Mole weight: 283.24. Appearance: Solid. Purity: 0.98. IUPACName: 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one. Canonical SMILES: C1=NC2=C (N1C3C (C (C (O3)CO)O)O)N=C (NC2=O)N. Density: 1.3790 g/cm³. Catalog: ACM118003.
Cationic guar gum is a modified, naturally derived (from the seeds of the guar plant cyampopis tetragonolobus) quaternary, high-molecular weight sugar polymer (polysaccharide) combining both thickening and conditioning effects. Uses: Shampoos, conditioners, lotions, creams, body washes, shower gels. Group: Cationic surfactants & conditioning agents. CAS No. 65497-29-2. Appearance: Yellowish powder, faint characteristic odor. Catalog: CI-HC-0061.
GUN35901
GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. GUN35901 is a demethyl analogue of DUN99845 (CAT#556012). GUN35901 was first reported in patent CN 112057443. Group: Inhibitors. Alternative Names: GUN35901; GUN-35901; GUN 35901; SN-011; SN011; SN 011. CAS No. 2249435-90-1. Molecular formula: C25H19FN2O4S. Mole weight: 462.5. Appearance: Solid powder. Purity: >98%. IUPACName: N-(3-((4-fluorophenyl)sulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide. Catalog: ACM2249435901.
Gymnemic Acid I
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress. Group: Inhibitors. CAS No. 122168-40-5. Molecular formula: C43H66O14. Mole weight: 806.97. Appearance: Powder. Purity: 0.98. IUPACName: (2S, 3S, 4S, 5R, 6R)-6-[[(3S, 4R, 4aR, 6aR, 6bS, 8S, 8aR, 9R, 10R, 12aS, 14aR, 14bR)-8a-(acetyloxymethyl)-8, 9-dihydroxy-4-(hydroxymethyl)-4, 6a, 6b, 11, 11, 14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1, 2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14, 14a-tetradecahydropicen-3-yl]oxy]-3, 4, 5-trihydroxyoxane-2-carboxylic acid. Canonical SMILES: CC=C (C)C (=O)OC1C (C2 (C (CC1 (C)C)C3=CCC4C5 (CCC (C (C5CCC4 (C3 (CC2O)C)C) (C)CO)OC6C (C (C (C (O6)C (=O)O)O)O)O)C)COC (=O)C)O. Catalog: ACM122168405.
gynostemma pentaphylla extractive
Anti-cancer: on liver cancer, lung cancer, metrocarcinoma, melanotic sarcoma; Anti-aging and improving immunity; Reducing blood fat; Prevent side-effect of glucocorticoid. Group: Material of health food. CAS No. 15588-68-8. Molecular formula: C80H126O44. Mole weight: 1791.83. Appearance: light yellow grown powder. Catalog: ACM15588688.
H-1152 Dihydrochloride
H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. Group: Inhibitors. Alternative Names: 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline. CAS No. 871543-07-6. Molecular formula: C16H23Cl2N3O2S. Mole weight: 392.34. Appearance: White to Off-White Solid. Catalog: ACM871543076.
HA14-1
HA14-1 is a potent Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. HA14-1 suppressed NF-kappaB activation through inhibition of phosphorylation and degradation of IkappaBalpha. This inhibition was correlated with suppression of NF-kappaB-dependent gene products (c-myc, cyclin D1, cox-2, and IAP-1). Additionally, HA14-1 also markedly sustained TNF-alpha-mediated JNK activation. Group: Inhibitors. Alternative Names: HA-141, HA 141, HA141. CAS No. 65673-63-4. Molecular formula: C17H17BrN2O5. Mole weight: 409.24. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate. Canonical SMILES: O=C (C1=C (N)OC2=C (C=C (Br)C=C2)[C@H]1[C@H] (C#N)C (OCC)=O)OCC. Catalog: ACM65673634.
Haemanthamine
Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities. Group: Inhibitors. Alternative Names: 3-Epicrinamine. CAS No. 466-75-1. Molecular formula: C17H19NO4. Mole weight: 301.34. Appearance: Solid. Purity: 90%+. Canonical SMILES: O[C@@H] (C1)[C@@]2 (C=C3)C4=CC (OCO5)=C5C=C4C[N@@]1[C@@]2 ([H])C[C@@H]3OC. Catalog: ACM466751.
Hafnium(IV) chloride is the inorganic compound with the formula HfCl4. This colourless solid is the precursor to most hafnium organometallic compounds. It has a variety of highly specialized applications, mainly in materials science and as a catalyst. Group: Heterocyclic organic compound. Alternative Names: Hafnium chloride(HfCl4);Hafnium(IV) chloride,-80 mesh; HAFNIUMANDITSCOMPOUNDS; hafnium(IV) chloride;HfCl4. CAS No. 13499-05-3. Molecular formula: Cl4Hf. Mole weight: 320.3. Appearance: White crystalline solid. ECNumber: 236-826-5. Catalog: ACM13499053.
Hair Dye Cherry
Synergistic complex of direct dyes and biotechnological ingredients including proteins and conditioning agents made specifically for semi-permanent hair coloring applications. Uses: Semi-permanent hair dye products. Group: Sensory modifiers. CAS No. 68123-13-7 / 26381-41-9 / 4430-18-6 / 68391-30-0 / 68391-31-1 / 77061-58-6 / 26161-33-1 / 100684-36-4. Appearance: Red powder. Catalog: CI-HC-0151.
Hair Dye Copper
Synergistic complex of direct dyes and biotechnological ingredients including proteins and conditioning agents made specifically for semi-permanent hair coloring applications. Uses: Semi-permanent hair dye products. Group: Sensory modifiers. CAS No. 68391-31-1 / 77061-58-6 / 26381-41-9 / 26161-33-1 / 100684-36-4. Appearance: Yellowish brown powder. Catalog: CI-HC-0154.