BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Vicriviroc Malate | Vicriviroc is a potent, orally active, selective inhibitor of CCR5 entry into HIV-1. It can effectively inhibit the initial stage of the virus life cycle. Synonyms: (4,6-dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone; 2-hydroxybutanedioicacid; VicrivirocMalate; 541503-81-5; S2004_Selleck; MolPort-016-633-267. Grades: 98%. CAS No. 541503-81-5. Molecular formula: C28H38F3N5O2.C4H6O5. Mole weight: 667.72. |  |
| Vidupiprant | This active molecular is a potent and selective D-prostanoid and CRTH2 inhibitor. IC50 values are 8 and 35 nM, respectively in plasma. Vidupiprant as an add-on to inhaled corticosteroid therapy demonstrated no associated risks but was not effective at improving asthma symptoms or lung function in patients with inadequately controlled moderate-to-severe asthma.symptoms or lung function in patients with inadequately controlled moderate-to-severe asthma. Uses: Asthma. Synonyms: 2-[4-[4- (tert-butylcarbamoyl) -2-[ (2-chloro-4-cyclopropylphenyl) sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]aceticacid; VIDUPIPRANT; UNII-61OTZ32XNC; CHEMBL1951575; CHEMBL 1951575; CHEMBL-1951575; AMG853; AMG 853; AMG-853; 1169483-24-2. Grades: 98%. CAS No. 1169483-24-2. Molecular formula: C28H27Cl2FN2O6S. Mole weight: 609.49. | |
| Vimseltinib | Vimseltinib is a selective dual inhibitor of CSF-1R (c-FMS) and c-Kit. Vimseltinib has been used in the research of tenosynovial giant cell tumor (TGCT). Synonyms: DCC-3014; DCC 3014; DCC3014. CAS No. 1628606-05-2. Molecular formula: C23H25N7O2. Mole weight: 431.49. | |
| Vincristine (free base) | The attenuating effect of VC in Vincristine-induced nociceptive painful sensation may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action. Uses: Antitumor. Synonyms: 22-Oxovincaleukoblastine; Leurocristine; rel-Vincristine; NSC-67574; Kyocristine. Grades: >98%. CAS No. 57-22-7. Molecular formula: C46H56N4O10. Mole weight: 824.96. | |
| Vindesine | Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer. Uses: Antineoplastic agents, phytogenic. Synonyms: Desacetylvinblastine amide; Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-; 3-carbamoyl-O (4)-deacetyl-3-de (methoxycarbonyl)vincaleukoblastine; CT-3231; CT 3231; CT3231. Grades: >98%. CAS No. 53643-48-4. Molecular formula: C43H55N5O7. Mole weight: 753.941. | |
| Vintafolide | Vintafolide is a water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of folate-vinca alkaloid conjugate EC145 binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine. Synonyms: EC-145; EC 145; EC145; KM-8109; KM 8109; KM8109; Vintafolide. CAS No. 742092-03-1. Molecular formula: C86H109N21O26S2. Mole weight: 1917.06. | |
| Vitamin D2 b-D-glucuronide sodium salt | Vitamin D2 b-D-glucuronide sodium salt is a biomedical product used for studying the metabolism and role of Vitamin D2 in the body. It is a derivative of Vitamin D2 that enables investigate its various functions. Synonyms: (3b,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-yl b-D-glucopyranosiduronic acid monosodium salt. CAS No. 85701-30-0. Molecular formula: C34H51NaO7. Mole weight: 594.75. | |
| VJ115 | VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis. Synonyms: VJ 115; VJ-115; (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)quinuclidin-3-ol. CAS No. 929256-79-1. Molecular formula: C23H24N2O. Mole weight: 344.45. | |
| VMY-1-103 | VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death Receptors DR4 and DR5, Bax and Bad while decreasing the number of viable cells, all supporting apoptosis as a mechanism of cell death. VMY-1-103 possesses unique antiproliferative capabilities and that this compound may form the basis of a new candidate drug to treat medulloblastoma. Synonyms: VMY1-103; VMY 1-103. Grades: 98%. CAS No. 1209002-43-6. Molecular formula: C34H42ClN9O4S. Mole weight: 708.28. | |
| Voglibose | Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia. Uses: Hypoglycemic agents. Synonyms: 3,4-Dideoxy-[2-hydroxy-1-(hydroxyethyl)ethyl] amino-1-C-(hydroxynethyl)-1,2,3,4-cyclohexaneterol; 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epiinositol. Grades: >98%. CAS No. 83480-29-9. Molecular formula: C10H21NO7. Mole weight: 267.28. | |
| vonicog α | Vonicog α is the first and only recombinant von Willebrand Factor(vWF) that offers von Willebrand Factoes(vWF) based on patients needs. It was approved by FDA in Dec. 2015 for the treatment of von Willebrand disease (VWD) in adullt patients. Uses: The treatment of von willebrand disease (vwd). Synonyms: Vonvendi. | |
| VRT-043198 | VRT-043198, the active metabolite of VX-765, is a Caspase inhibitor. VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9. VRT-043198 inhibited the release of interleukin (IL)-1beta and IL-18, but it had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8. Synonyms: VRT043198; VRT 043198; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide; (S)-3-({1-((S)-1-((S)-2-{(1-(4-Amino-3-chlorophenyl)methanoyl)amino}-3,3-dimethyl-butanoyl)pyrrolidin-2-yl)methanoyl}amino)-4-oxobutyric acid. Grades: ≥98%. CAS No. 244133-31-1. Molecular formula: C22H29ClN4O6. Mole weight: 480.94. | |
| VT-464 | VT-464, also called as Seviteronel, is an oral, non-steroidal, lyase-selective CYP17 inhibitor to reach Phase II clinical trials in Breast cancer in USA (PO). in vitro: Approximately 10-fold more selective towards lyase than hydroxylase. Selective inhibit. Uses: Antineoplastic agents. Synonyms: (1S)-1-[6,7-bis(difluoromethoxy)naphthalen-2-yl]-2-methyl-1-(2H-triazol-4-yl)propan-1-ol; VT464; VT 464; VT-464; INO-464; INO 464; INO464;CHEMBL3264610; CS-3139; CS 3139; CS3139; HY-15996; UNII-8S5OIN36X4 component ZBRAJOQFSNYJMF-SFHVURJKSA-N; 1610537-15-9; 1H-1,2,3-Triazole-5-methanol, alpha-(6,7-bis(difluoromethoxy). CAS No. 1610537-15-9. Molecular formula: C18H17F4N3O3. Mole weight: 399.34. | |
| VT-464 racemate | The racemate form of VT-464, a non-steroidal compound, has been found to lead to the reduction of androgen through acting as a human CYP17 lyase inhibitor. IC50: 69 nM. Uses: The racemate form of vt-464 has been found to lead to the reduction of androgen through acting as a human cyp17 lyase inhibitor. Synonyms: VT-464 racemate; VT 464 racemate; VT464 racemate; VT-464; CHEMBL3264610; CS-3139; CS 3139; CS3139; UNII-8S5OIN36X4 component ZBRAJOQFSNYJMF-SFHVURJKSA-N. Grades: 98%. CAS No. 1375603-36-3. Molecular formula: C18H17F4N3O3. Mole weight: 399.34. | |
| VT-464 R enantiomer | The R-enantiomer form of VT-464, a non-steroidal compound, has been found to lead to the reduction of androgen through acting as a human CYP17 lyase inhibitor. Uses: The r-enantiomer form of vt-464 has been found to lead to the reduction of androgen through acting as a human cyp17 lyase inhibitor. Synonyms: VT-464 (R enantiomer); VT 464 R enantiomer; VT464 R enantiomer; CS-3140; CS 3140; CS3140; UNII-8S5OIN36X4 component ZBRAJOQFSNYJMF-GOSISDBHSA-N. Grades: 98%. CAS No. 1375603-38-5. Molecular formula: C18H17F4N3O3. Mole weight: 399.34. | |
| VU 0364770 | VU 0364770 is systemically active positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 4 (mGluR4) (EC50: 290 nM). It showed efficacy alone or when administered in combination with L-DOPA or an adenosine 2A (A2A) receptor antagonist, in several rodent PD models. Synonyms: VU0364770; VU-0364770; N-(3-chlorophenyl)picolinamide; N-(3-chlorophenyl)-2-pyridinecarboxamide. Grades: >98%. CAS No. 61350-00-3. Molecular formula: C12H9ClN2O. Mole weight: 232.67. | |
| VU 0409551 | VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Synonyms: VU0409551; VU-0409551; VU 0409551; JNJ-46778212; JNJ 46778212; JNJ46778212;(4-fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone. Grades: 98%. CAS No. 1363281-27-9. Molecular formula: C20H17FN2O3. Mole weight: 352.37. | |
| Vudalimab | Vudalimab is a humanized bispecific monoclonal antibody targeting both PD-1 and CTLA-4. Vudalimab inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. CAS No. 2329669-72-7. | |
| VX-148 | VX-148 is a novel, uncompetitive IMPDH inhibitor with a K(I) value of 6 nM against IMPDH type II enzyme. VX-148 is slightly more potent than mycophenolic acid and VX-497 in inhibiting the proliferation of mitogen-stimulated primary human lymphocytes (IC(50) value of ~80 nM). VX-148 does not inhibit proliferation of nonlymphoid cell types such as fibroblasts, indicating selectivity for inhibition of IMPDH activity. VX-148 significantly prolongs skin graft survival at 100 mg/kg b.i.d. in mice. Synonyms: VX148; VX 148; (R)-1-cyanobutan-2-yl ( (S) -1- (3- (3- (4-cyano-3-methoxyphenyl) ureido) phenyl) ethyl) carbamate. Grades: 98%. CAS No. 297730-05-3. Molecular formula: C23H25N5O4. Mole weight: 435.48. | |
| VZHE-039 | VZHE-039 is a structurally-enhanced allosteric hemoglobin effector. Study in vitro showed that VZHE-039 inhibited sickling of SS erythrocytes in a dose-dependent manner. The result of in vivo studies showed that AUCtrap increased supra-proportionally with dose after I.P. administration; the limited sampling schedule suggested an I.P. bioavailability of >20%. VZHE-039 is promisingly to be a novel anti-sickling drug. Uses: Potential anti-sickling drug. Synonyms: VZHE-039; VZHE039. | |
| WAY 207024 dihydrochloride | WAY 207024 dihydrochloride is a potent and orally bioactive antagonist of gonadotropin releasing hormone receptor (GnRH-R) (IC50 = 12 and 71 nM for human and rat GnRH receptors, respectively). WAY 207024 dihydrochloride was shown to decrease plasma leuteinizing hormone levels in the rat. Synonyms: WAY-207024 ; WAY 207024 ; WAY207024; WAY 207024 dihydrochloride; WAY 207024 diHCl; 6-[[4-[2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazol-7-yl]-i-piperazinyl]methyl]-quinoxaline dihydrochloride. Grades: ≥99% by HPLC. CAS No. 872002-73-8. Molecular formula: C30H32N6.2HCl. Mole weight: 549.54. | |
| WAY 213613 | WAY 213613 is a potent and non-substrate inhibitor of EAAT2 (GLT-1), displaying > 44-fold selectivity over EAAT1 and EAAT3 (IC50 = 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1, respectively). WAY 213613 exhibits no activity towards ionotropic and metabotropic glutamate receptors. Synonyms: WAY 213613; WAY213613; WAY-213613; N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine; (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid. Grades: ≥99% by HPLC. CAS No. 868359-05-1. Molecular formula: C16H13BrF2N2O4. Mole weight: 415.19. | |
| WAY-255348 | WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. Synonyms: WAY255348; WAY 255348. Grades: 98%. CAS No. 872141-23-6. Molecular formula: C16H14FN3O. Mole weight: 283.30. | |
| WH-4-023 | WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 values of 2 nM and 6 nM for Lck and Src kinase respectively. In combination with PD 0325901, CHIR99021 and SB-590885, WH-4-023 was found to support self-renewal of naive human embryonic stem cells (hESCs). Synonyms: KIN001-112; KIN112; 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate. Grades: >98%. CAS No. 837422-57-8. Molecular formula: C32H36N6O4. Mole weight: 568.67. | |
| WHI-P154 | WHI-P154 is a JAK3 inhibitor with IC50 value of 1.8 μM. It also inhibits other kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines. It enhances differentiation of neural progenitor cells. Synonyms: JAK3 inhibitor II; WHI-P 154; 2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol. Grades: >98%. CAS No. 211555-04-3. Molecular formula: C16H14BrN3O3. Mole weight: 376.21. | |
| WHI-P97 | WHI-P97 is a potent, cell-permeable and specific inhibitor of JAK3 (IC50 = 11 μM). It inhibits JAK3 in immune complex kinase assays in a dose-dependent fashion and reduces the invasiveness of EGFR positive human cancer cells in a dose-dependent manner. Synonyms: 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol. Grades: >98%. CAS No. 211555-05-4. Molecular formula: C16H13Br2N3O3. Mole weight: 455.1. | |
| WIKI4 | WIKI4 is a potent and selective inhibitor of Wnt/ß-catenin signaling. It inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC50 of 15 nM. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. Synonyms: WIKI-4; 2- [3- [ [4- (4-methoxyphenyl) -5-pyridin-4-yl-1, 2, 4-triazol-3-yl]sulfanyl]propyl]benzo [de]isoquinoline-1, 3-dione. Grades: >98%. CAS No. 838818-26-1. Molecular formula: C29H23N5O3S. Mole weight: 521.595. | |
| WK-643 | WK-643 is a novel Lysine (K) inhibitor potentially used as an antihypertensive drug. It showed high activity in preclinical high blood pressure model. Uses: Potential antihypertensive drug. Synonyms: WK 643; WK643. | |
| WK-X-34 | WK-X-34 is Inhibitor of P-glycoprotein and BCRP. Synonyms: WKX34; WKX-34; WKX 34; WK-X 34; WK-X34. Grades: 98%. CAS No. 908859-10-9. Molecular formula: C35H37N3O6. Mole weight: 595.70. | |
| Wogonoside | Wogonoside has shown preclinical anticancer efficacy in various cancer models. Wogonoside has been reported to have anti-inflammatory properties. Uses: Anti-inflammatory. Synonyms: Wogonin 7-O-b-D-glucuronide; Oroxindin. Grades: >98%. CAS No. 51059-44-0. Molecular formula: C22H20O11. Mole weight: 460.39. | |
| WP-1034 | WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP). Synonyms: WP1034; WP 1034; (R,E)-2-cyano-3-(4-nitrophenyl)-N-(1-phenylethyl)acrylamide. CAS No. 857064-42-7. Molecular formula: C18H15N3O3. Mole weight: 321.33. | |
| WP1066 | WP1066 is a JAK2 and STAT3 inhibitor. It was shown to inhibit proliferation and induce apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide. Grades: >98%. CAS No. 857064-38-1. Molecular formula: C17H14BrN3O. Mole weight: 356.223. | |
| X4-136 | X4-136 is a novel small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4). Study in C57BL/6J mice model indicated that it exhibited an effct of long term control on tumor and improved survival when synergistically used with anti-PD-1. Combination therapy of X4-136 and anti-PD-1 is superior to single anti-PD-1 therapy. Uses: Combination therapy of x4-136 and anti-pd-1. | |
| Xaliproden hydrochloride | Xaliproden hydrochloride is a potent, selective and orally active 5-HT1A receptor agonist with a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50 = 3 nM). It is also a selective dopamine D2 receptor antagonist with moderate affinity (IC50 = 0.1-1 μM). It has antidepressant and anti-anxiety effects, and may have therapeutic potential in neurodegenerative diseases research. Uses: Serotonin 5-ht1 receptor agonists. Synonyms: SR57746A; SR57746 hydrochloride; 1-[2-(2-Naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride; 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride. Grades: ≥99%. CAS No. 90494-79-4. Molecular formula: C24H23ClF3N. Mole weight: 417.89. | |
| X-Gal | X-Gal is a fluorecent substrate for β-galactosidase and blue-white selection of recombinant bacterial colonies with the lac+ genotype. Synonyms: 5-Bromo-4-chloro-3-indolyl β-D-galactopyranoside; X-b-D-Galactoside; BCIG. CAS No. 7240-90-6. Molecular formula: C14H15BrClNO6. Mole weight: 408.64. | |
| XK469 | XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. Synonyms: XK 469; XK-469; NSC-698216; 2-(4-((7-Chloro-2-quinoxalinyl)oxy)phenoxy)propanoic acid. CAS No. 157435-10-4. Molecular formula: C17H13ClN2O4. Mole weight: 344.75. | |
| XL019 | XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, displaying 100-fold selectivity over JAK1. XL019 inhibits proliferation and induce apoptosis in cells carrying the JAK2V617F mutation. Synonyms: (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide; XL-019. Grades: >98%. CAS No. 945755-56-6. Molecular formula: C25H28N6O2. Mole weight: 444.539. | |
| XL413 | XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, with a 60-fold selectivity against CK2,10-fold selectivity against PIM, and 300-fold selectivity against a panel of over 100 protein kinases. Synonyms: BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413. Grades: >98%. CAS No. 1169558-38-6. Molecular formula: C14H12ClN3O2. Mole weight: 289.72. | |
| XL413 hydrochloride | XL413 is a potent and selective inhibitor of Cdc7 with IC50 value of 3.4 nM. It exhibits >60, >10, and >300-fold selectivity for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. Synonyms: 8-Chloro-2-[(2S)-pyrrolidin-2-yl]-4aH-[1]benzofuro[3,2-d]pyrimidin-4-one hydrochloride. Grades: ≥98%. CAS No. 2062200-97-7. Molecular formula: C14H12ClN3O2·HCl. Mole weight: 326.18. | |
| XMT-1001 | Polymeric camptothecin prodrug XMT-1001 is a polymeric prodrug of camptothecin (CPT) with potential antineoplastic activity. Polymeric camptothecin prodrug XMT-1001 consists of CPT conjugated to the 60-70 kDa, inert, bio-degradable, hydrophilic copolymer poly[1-hydroxymethylene hydroxymethyl formal] (PHF). Through a dual-phase, non-enzymatic release mechanism, CPT is first released in plasma from XMT-1001 as the lipophilic prodrugs CPT-SI (a succinimidoglycinate derivative) and CPT-SA (a succinamidoyl glycinate derivative), which are then hydrolyzed within tissues to release the lactone form of CPT. CPT inhibits the catalytic activity of DNA topoisomerase I, thereby inhibiting DNA replication and inducing apoptosis. This agent may exhibit a more favorable pharmacokinetic profile than other agents in the same class. Synonyms: XMT-1001; XMT1001; XMT 1001; A poly(1-hydroxymethylethylene hydroxymethylformal) (Fleximer)-camptothecin conjugate. CAS No. 1252797-26-4. | |
| XMT-1107 | XMT-1107 is a polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered to the hydrophilic, biodegradable70 kDa polymer poly[1- hydroxymethylethylene hydroxymethylformal] (PHF) with potential antiangiogenic and antineoplastic activities. Upon administration, fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit angiogenesis through the irreversible inhibition of the methionine aminopeptidase 2 (METAP2); although the exact mechanism of action has yet to be fully elucidated, this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107 exhibits improved solubility and an extended half life due to its PHF backbone. METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types. Synonyms: XMT-1107; XMT1107; XMT 1107; A poly(1-hydroxymethylethylene hydroxymethylformal) (Fleximer)-fumagillol conjugate. CAS No. 1252797-29-7. | |
| XMU-MP-1 | XMU-MP-1 is a reversible and selective MST1/2 inhibitor. It suppresses activities of MST1/2 kinase, then activating the downstream effector Yes-associated protein and promoting cell growth. Studies indicated that the pharmacological modulation of MST1/2 kinase activities offered a new way to potentiate tissue repair and regeneration, and XMU-MP-1 is the first lead for the development of targeted regenerative therapeutics. Uses: Targeted regenerative therapeutics. Synonyms: 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide; 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide; Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-. Grades: >98%. CAS No. 2061980-01-4. Molecular formula: C17H16N6O3S2. Mole weight: 416.48. | |
| X-NeuNAc | Used as a substrate for the detection of sialidase-like enzyme in screening of enzymes, studying physiological activities of gangliosides, and recombinant technologies. Synonyms: N-Acetyl-2-O-(5-bromo-4-chloro-1H-indol-3-yl)-α-neuraminic Acid Monosodium Salt; 5-bromo-4-chloro-1H-indol-3-yl 5-(Acetylamino)-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosidonic Acid Monosodium Salt; 5-Bromo-4-chloro-3-indolyl-α-D-N-acetylneuraminic acid sodium salt. Grades: ≥98.0%. CAS No. 160369-85-7. Molecular formula: C19H25N2NaO3S. Mole weight: 559.73. | |
| XR3054 | XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 but was relatively inactive when tested against a panel of breast carcinoma cell lines. In conclusion XR3054 inhibits ras farnesylation, MAP kinase activation and anchorage-independent growth in NIH 3T3 transformed with v12 H-ras. XR3054 may also have effects on other cell signaling mechanisms. Synonyms: XR-3054; XR 3054; (4beta)-1beta,7-(Isopropylidenedioxy)-p-mentha-8-ene. Grades: 98%. CAS No. 247090-97-7. Molecular formula: C13H22O2. Mole weight: 210.31. | |
| XR9051 | XR9051 is as a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor of the binding of the cytotoxic to P-glycoprotein. XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein. Synonyms: XR-9051; XR 9051. CAS No. 762219-35-2. Molecular formula: C39H38N4O5. Mole weight: 642.76. | |
| Xylaric acid disodium salt | Xylaric acid disodium salt is a bioactive compound used in the research of mycotic infections, showcasing formidable antifungal attributes, capable of studying diverse fungal strains. This chemical compound fosters the R&D of bespoke antifungal therapeutics catered to studying ailment instigated by fungal etiologies. Synonyms: 2-(4-Oxopyran-3-yl)acetic acid sodium salt; 2,3,4-Trihydroxy-xylo-glutaric acid sodium salt; Disodium xylarate; Sodium xylosaccharate. CAS No. 91400-18-9. Molecular formula: C5H6Na2O7. Mole weight: 224.08. | |
| Xylitol bp/ep | | |
| Xylocydine | Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as in cell cultures, that is temporally associated with apoptotic cell death in xylocydine-induced HCC cells. Synonyms: 4-Amino-6-bromo-7-beta-L-xylofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. Grades: 98%. CAS No. 685901-63-7. Molecular formula: C12H14BrN5O5. Mole weight: 388.17. | |
| Xylonic acid-1,4-lactone | Xylonic acid-1,4-lactone is a multifaceted compound with intrinsic anti-inflammatory prowess and innate propensity to quell oxidative stress, used for studying cardiovascular disorders. Synonyms: Xylono-1,4-lactone; (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one; Xylonic acid gamma-lactone; Xylono γ-lactone. Grades: 95%. CAS No. 18423-66-0. Molecular formula: C5H8O5. Mole weight: 148.114. | |
| Y11 | Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Targeting the major autophosphorylation site of FAK with Y11 inhibitor is critical for development of cancer therapeutics and carcinogenesis field. Synonyms: Y-11; Y 11; NSC-206142; 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide. Grades: 98%. CAS No. 1086639-59-9. Molecular formula: C8H17BrN4O. Mole weight: 265.15. | |
| Y16 | Y16 is an inhibitor of G-protein-coupled Rho GEFs. It specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways and blocks the growth and migration of MCF7 breast cancer cells. Synonyms: RhoA-IN-Y16; Y16; Y-16; Y 16. Grades: >98%. CAS No. 429653-73-6. Molecular formula: C24H20N2O3. Mole weight: 384.43. | |
| Y27632 | Y-27632 is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 increases the release of neurotransmitters from cholinergic nerves. Uses: Reprogramming, self-renewal. Synonyms: Y27632; Y 27632; Y-27632. Grades: 98% by HPLC. CAS No. 146986-50-7. Molecular formula: C14H21N3O. Mole weight: 247.34. | |
| Y-33075 dihydrochloride | Y-33075 dihydrochloride is a selective ROCK inhibitor (IC50 = 3.6 nM) derived from Y-27632. Y-39983 increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats. Synonyms: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide dihydrochloride; SNJ-1656; Y-3998. Grades: >98%. CAS No. 173897-44-4. Molecular formula: C16H18Cl2N4O. Mole weight: 353.25. | |
| YC-137 | YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Synonyms: YC 137; YC137. CAS No. 810659-53-1. Molecular formula: C24H21N3O6S2. Mole weight: 511.57. | |
| YF-18 | YF-18 is a matrine derivative that has an inhibitory effect on lung cancer cells. Studies indicated that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. In addition, it suppressed cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Uses: Anti-lung cancer. Synonyms: YF 18; YF18. | |
| YH239-EE | YH239-EE is an ethyl ester of YH239, which acts as a MDM2-p53 inhibitor. YH239-EE induces apoptosis in four AML cells. It promotes survival of aged muscle stem cells (muSCs). Synonyms: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate. Grades: >98%. CAS No. 1364488-67-4. Molecular formula: C25H27Cl2N3O4. Mole weight: 504.41. | |
| YHO-13177 | YHO-13177 is a potent and specific inhibitor of BCRP. It potentiated the cytotoxicity of SN-38 in cancer cells and had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells. Synonyms: YHO-13177; YHO 13177; YHO13177. Grades: >98%. CAS No. 912287-56-0. Molecular formula: C20H22N2O3S. Mole weight: 370.47. | |
| YHO-13351 | YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP. Synonyms: YHO-13351; YHO 13351; YHO13351. Grades: >98%. CAS No. 1346753-00-1. Molecular formula: C27H37N3O7S2. Mole weight: 579.73. | |
| YHO-13351 free base | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. | |
| YKL-06-062 | YKL-06-062 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 2.12 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Synonyms: YKL 06 062. CAS No. 2172617-16-0. Molecular formula: C31H39N7O. Mole weight: 525.69. | |
| YM 022 | YM 022 is a highly potent and selective non-peptide CCK2 silent antagonist (Ki = 68 pM and 63 nM at CCK2 and CCK1 receptors, respectively). YM 022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo with a long duration of action. Synonyms: YM022; YM-022; (R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; N-[(3R)-2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea; 3-(3-methylphenyl)-1-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea. Grades: ≥99% by HPLC. CAS No. 145084-28-2. Molecular formula: C32H28N4O3. Mole weight: 516.59. | |
| YM 511 | YM 511 is a potent aromatase (CYP19) inhibitor (IC50 = 0.4 and 0.12 nM at rat ovary and human placenta cells, respectively) that weakly inhibits the synthesis of other steroid hormones. YM 511 decreases plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM). Synonyms: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile; YM511; YM-511; YM 511. Grades: ≥99% by HPLC. CAS No. 148869-05-0. Molecular formula: C16H12BrN5. Mole weight: 354.2. | |
| YM 58483 | YM 58483 is a calcium release-activated calcium (CRAC) channel inhibitor. YM 58483 suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM), cytokine production and proliferation of T cells in vitro. YM 58483 exhibits immuno-modulatory and anti-inflammatory activity. Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; Btp2; YM-58483; YM 58483; CRAC Channel Inhibitor, BTP2. Grades: ≥99% by HPLC. CAS No. 223499-30-7. Molecular formula: C15H9F6N5OS. Mole weight: 421.32. | |
| Yoda 1 | Yoda 1 is a glycine transporters GLYT2 inhibitor as a novel agonist of the mechanotransduction channel Piezo1. Uses: Piezo1 channel activator. Synonyms: GlyT2-IN-1; Yoda1; Yoda-1; Yoda 1;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole. Grades: ≥98 %. CAS No. 448947-81-7. Molecular formula: C13H8Cl2N4S2. Mole weight: 355.27. | |
| YU238259 | YU238259 is a novel inhibitor of homology-dependent DNA repair (HDR) while not inhibiting non-homologous end-joining in cell-based GFP reporter assays. Treatment with YU238259 is not only synergistic with ionizing radiation (IR), etoposide, and PARP inhibition, but this synergism is heightened by BRCA2-deficiency. Synonyms: YU238259; YU 238259; YU-238259; SCHEMBL17912765; ZINC669685255; N-[2- (5-chloropyridin-2-yl) ethyl]-4-[[ (4-methoxyphenyl) sulfonylamino]methyl]benzamide. Grades: 99.28 %. CAS No. 1943733-16-1. Molecular formula: C22H22ClN3O4S. Mole weight: 459.95. | |
| YVAD-CHO trifluoroacetate salt | YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE). It inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells. Grades: ≥95%. Molecular formula: C21H30N4O7·xCF3COOH. Mole weight: 450.49. | |
| Z2 | Z2 is a promising Zika virus (ZIKV) inhibitor derived from the stem region of Zika virus (ZIKV) envelope protein. Studies indicated that Z2 functioned via interacting with ZIKV surface protein and inhibiting the integrity of the viral membrane. Uses: The potential treatment of zika virus (zikv) infection. | |
| Z-3259 | XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4. Synonyms: N-(3,4-Dichloro-5-fluorophenyl)-6-methoxy-7-[(1-methylazocan-5-yl)methoxy]quinazolin-4-amine; A11057. Grades: 98%. CAS No. 874286-84-7. Molecular formula: C24H27Cl2FN4O2. Mole weight: 493.40. | |
| (Z)-3-Hexen-1-yl b-D-glucopyranoside | (Z)-3-Hexen-1-yl b-D-glucopyranoside, a naturally occurring glycoside compound derived from plants, displays potent anti-inflammatory and anti-oxidant properties. This unique compound is highly sought-after for its therapeutic potential, especially in neurodegenerative diseases such as Alzheimers and Parkinsons. Notably, scientific research has confirmed the powerful neuroprotective effects of (Z)-3-Hexen-1-yl b-D-glucopyranoside, highlighting its tremendous potential in the realm of medical research. Synonyms: (Z)-3-Hexen-1-yl b-D-glucopyranoside; (z)-3-hexenyl beta-d-glucopyranoside; cis-3-hexenol glucoside; CHEMBL3609350; CHEBI:182449; DTXSID201345635; 3-Hexen-1-ol O-b-D-glucopyranoside; AKOS040734032; (2R,3R,4S,5S,6R)-2-[(Z)-hex-3-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol; NCGC00380275-01; NCGC00380275-01_C12H22O6_beta-D-Glucopyranoside, (3Z)-3-hexen-1-yl; (2R,3R,4S,5S,6R)-2-[(Z)-hex-3-enoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol. CAS No. 95632-87-4. Molecular formula: C12H22O6. Mole weight: 262.30. | |
| Zagotenemab | Zagotenemab is a humanized monoclonal antibody targeting aggregated tau. Zagotenemab has been used for te treatment of Alzheimer's Disease. Synonyms: LY3303560; LY 3303560; LY-3303560. CAS No. 2019133-28-7. | |
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