BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SPR-00305 | SPR-00305 is a potent MvfR pathway inhibitor (IC50 = 93 nM against PYO, 115 nM against HHQ and 109 nM against PQS in PA14). It exhibits an inhibitory effect against Pseudomonas aeruginosa (Pa), which is resistant to many antibiotics. SPR-00305 is active in both chronic and acute inflammation. Uses: Antibiotic. Synonyms: SPR00305; SPR 00305. CAS No. 1965261-97-5. Molecular formula: C24H19ClN2O3. Mole weight: 418.88. |  |
| (S)-Propranolol β-D-Glucuronide Sodium Salt | A metabolite of Propranolol.Propranolol is Beta 1 adrenergic receptor antagonist. It can be used for the treatment of high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors. Synonyms: (S)-1-[[(1-Methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl b-D-glucopyranosiduronic acid monosodium salt; (-)-Propranolol glucuronide sodium; (S)-Propranolol glucuronide sodium. Grades: > 95%. CAS No. 87144-73-8. Molecular formula: C22H28NNaO8. Mole weight: 457.45. | |
| (S)-Propranolol glucuronide | (S)-Propranolol glucuronide is the metabolite formed in vivo upon the administration of Propranololan efficacious beta-blocker that features in the treatment of hypertension, angina, and arrhythmias. This glucuronide is inactivated and subsequently renally cleared via the urinary tract. The relatively low molecular weight of (S)-Propranolol glucuronide, which permits facile urine excretion, belies its significance as a marker for assessing the pharmacokinetics of Propranolol. Molecular formula: C22H29NO8. Mole weight: 435.47. | |
| SQ-22536 | SQ-22536, also known as NSC 53339, is a cell-permeable adenylyl cyclase inhibitor (IC50 = 20 μM in detergent-dispersed rat brain preparation). SQ 22536 has demonstrated inhibition of the effect of glucagon on rat membrane cyclase activity and has reduced the effect of isoproterenol, epinephrine, norepinephrine, and phenylephrine. Synonyms: 9-(tetrahydro-2-furanyl)-9H-purin-6-amine; SQ-22536; SQ22536; SQ 22536; SQ-22,536; SQ22,536; SQ 22,536. NSC 53339. CAS No. 17318-31-9. Molecular formula: C9H11N5O. Mole weight: 205.22. | |
| SR13668 | SR13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: SR 13668; SR-13668; 2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo[2,3-b]carbazole. CAS No. 637774-61-9. Molecular formula: C25H22N2O5. Mole weight: 430.46. | |
| SR142948A | SR142948A is an antagonist of non-peptide neurotensin (NT) receptor with a high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). SR142948A has the effect of inhibiting bile acid secretion and some stimulant drugs. Uses: An antagonist of non-peptide neurotensin (nt) receptor with an effect of bile acid secretion inhibition. Synonyms: SR 142948; SR 142948A; CHEMBL2431105; CHEMBL 2431105; CHEMBL-2431105; AC1NSKNX. Grades: ≥98 %. CAS No. 184162-64-9. Molecular formula: C39H51N5O6. Mole weight: 685.86. | |
| SR 27897 | SR 27897 is a potent and non-peptide CCK1 receptor antagonist displaying > 33-fold selectivity over CCK2 receptors (EC50 = 6 and 200 nM, respectively). It was shown to increase plasma leptin levels and promote food intake in rats in vivo. SR 27897 is used for the treatment of pancreatic cancer. Uses: The treatment of pancreatic cancer. Synonyms: SR-27897; SR27897; SR 27897; 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid; Lintitript. Grades: ≥99% by HPLC. CAS No. 136381-85-6. Molecular formula: C20H14ClN3O3S. Mole weight: 411.86. | |
| SR-31747 | SR-31747 is a new sigma ligand, which elicited a suppressive effect on immune responses through the sigma receptor expressed on lymphocytes. Synonyms: N-Cyclohexyl-N-ethyl-3-(3-chloro-4-cyclohexylphenyl)propen-2-ylamine hydrochloride; SR 31747 HCl. Grades: 98%. CAS No. 132173-07-0. Molecular formula: C23H35Cl2N. Mole weight: 396.44. | |
| SR 3677 | SR 3677 is an effective ROCK inhibitor, espectially against ROCK II and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueous humor in porcine eyes in ex-vivo study. And it was also found to have the potential use to p. Uses: Sr 3677 is an effective rock inhibitor, espectially against rock ii and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueous humor in porcine eyes in ex-vivo study. Synonyms: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide;SR 3677 hydrochloride;SR3677; SR-3677; SR 3677. Grades: >98 %. CAS No. 1072959-67-1. Molecular formula: C22H24N4O4. Mole weight: 408.45. | |
| SR4554 | SR4554 is a fluorine-containing 2-nitroimidazole, designed as a hypoxia marker detectable with 19F magnetic resonance spectroscopy (MRS). SR-4554 has plasma pharmacokinetic and toxicity profiles suitable for use as a hypoxia probe. It can be detected in tumors by unlocalized MRS. Additional clinical studies are warranted. Synonyms: SR-4554; SR 4554; N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamide. CAS No. 167648-73-9. Molecular formula: C8H9F3N4O4. Mole weight: 282.18. | |
| SR 9186 | SR 9186 is an inhibitor of the cytochrome P450 isoform CYP3A4 with IC50 value of 0.011 μM. Synonyms: 1-[4-(4-Cyanophenyl)phenyl]-3-[4-(1H-imidazo[4,5-b]pyridin-7-yl)phenyl]urea. Grades: ≥95%. CAS No. 1361414-26-7. Molecular formula: C26H18N6O. Mole weight: 430.5. | |
| SRT2183 | SRT2183 is a Sirt1 activator, currently being developed by Sirtris Pharmaceuticals. SRT2183 has similar activity in the body to another SIRT1 activator SRT1720, but is closer in potency to resveratrol. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function. Synonyms: SRT 2183; SRT-2183; (R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide. Grades: 98%. CAS No. 1001908-89-9. Molecular formula: C27H24N4O2S. Mole weight: 468.575. | |
| (S)-Ruxolitinib | Ruxolitinib S enantiomer, the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor to enter the clinic. It was initially developed to target the constitutive activation of the JAK-STAT pathway. It maintains its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. It is well absorbed at above 95%. Synonyms: (S)-INCB018424; S-Ruxolitinib; SRuxolitinib; S Ruxolitinib; INCB-18424. Grades: >98%. CAS No. 941685-37-6. Molecular formula: C17H18N6. Mole weight: 306.37. | |
| (S,S)-(-)-1,4-Dimethoxy-2,3-butanediol | (S,S)-(-)-1,4-Dimethoxy-2,3-butanediol, an intriguing chemical compound renowned for its multifaceted biomedical potential, assumes a pivotal role in synthesizing an extensive range of formidable pharmaceutical intermediates. Synonyms: (-)-1,4-Di-O-methyl-L-threitol. CAS No. 50622-10-1. Molecular formula: C6H14O4. Mole weight: 150.17. | |
| SSR 504734 | SSR 504734 is a potent and orally bioactive GlyT-1 inhibitor blocking the ex vivo uptake of glycine reversibly in animal models of schizophrenia, anxiety and depression. Synonyms: D06SBS; SSR 504734; SSR504734; SSR-504734; 2-chloro-N-[(S)-phenyl-[(2S)-piperidin-2-yl]methyl]-3-(trifluoromethyl)benzamide hydrochloride. Grades: 99%. CAS No. 615571-23-8. Molecular formula: C20H20ClF3N2O.HCl. Mole weight: 433.29. | |
| ST034307 | ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM) without significant activity on other AC isoforms. Synonyms: ST034307; ST 034307; ST-034307; 6-chloro-2-(trichloromethyl)chromen-4-one. CAS No. 133406-29-8. Molecular formula: C10H4Cl4O2. Mole weight: 297.95. | |
| STA-21 | Cas No. 111540-00-2. | |
| STA-9584 | STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P). It is noteworthy that histological analysis revealed that STA-9584 disrupted microvasculature at both the center and periphery of tumors. Compared with CA4P, STA-9584 induced a 73% increase in central necrotic area, 77% decrease in microvasculature, and 7-fold increase in tumor cell apoptosis in the remaining viable rim 24 h post-treatment. Ultrasound imaging confirmed that STA-9584 rapidly and efficiently blocked blood flow in highly perfused tumor regions. Moreover, cardiovascular effects were evaluated in the Langendorff assay and telemetered dogs, and cardiovascular toxicity was not predicted to be dose-limiting. This bioactivity profile distinguishes STA-9584 from the combretastatin class and identifies the compound as a promising new therapeutic VDA candidate. Synonyms: STA 9584; STA9584. CAS No. 906481-23-0. Molecular formula: C28H30ClN3O6. Mole weight: 540.01. | |
| Stannsoporfin | Stannsoporfin (SnMP) is a porphyrin-Sn(IV) complex, is also a potent heme oxygenase inhibitor, that inhibits HO-1-mediated heme catabolism with potential medicinal application for the treatment of both neonatal jaundice and inherited hyperbilirubinemia syndromes. It was developed to possess unique structural and photophysical properties that make it a particularly potent and bioavailable in vivo inhibitor suitable for clinical use in newborns and studies to date have revealed a very favorable therapeutic profile with no significant adverse side effects. Synonyms: Tin mesoporphyrin; SNMPP; SnMP; Sn Mesoporphyrin; Stanate; Sn(IV) Mesoporphyrin IX Dichloride. CAS No. 106344-20-1. Molecular formula: C34H36Cl2N4O4Sn. Mole weight: 754.29. | |
| Stattic | Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Synonyms: 6-Nitrobenzo[b]thiophene 1,1-dioxide; 6-nitro-1-benzothiophene 1,1-dioxide. Grades: >98%. CAS No. 19983-44-9. Molecular formula: C8H5NO4S. Mole weight: 211.19. | |
| Stearda | Stearda is an endogenous fatty acid dopamide that is inactive at TRPV1 and CB1 receptors at concentrations up to 5 μM and exhibits no inhibitory effects on AMT or FAAH (IC50 > 25 μM). However, stearda potentiates TRPV1-mediated effects of NADA in vitro and in vivo, and enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. It also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM). Synonyms: N-(3,4-dihydroxyphenethyl)stearamide; N-stearoyl-dopamine. Grades: ≥98% by HPLC. CAS No. 105955-10-0. Molecular formula: C26H45NO3. Mole weight: 419.64. | |
| Stepronin | Stepronin is a mucolytic and expectorant and it can be used for the treatment of Bronchitis and Otorhinolaryngological infections. Uses: Bronchitis; otorhinolaryngological infections. Synonyms: (2-((thiophene-2-carbonyl)thio)propanoyl)glycine; Tiofacic; Prostenoglycine; Bronco-plus; TTPG; Glycine, N-(1-oxo-2-((2-thienylcarbonyl)thio)propyl)-. Grades: 98%. CAS No. 72324-18-6. Molecular formula: C10H11NO4S2. Mole weight: 273.32. | |
| STF-118804 | STF-118804 is a potent and highly specific NAMPT inhibitor. It has been shown to improve survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and target leukemia stem cells. Synonyms: STF 118804; 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide. Grades: >98%. CAS No. 894187-61-2. Molecular formula: C25H23N3O4S. Mole weight: 461.536. | |
| STF-31 | STF-31 is a selective glucose transporter GLUT1 inhibitor. It effectively eliminates undifferentiated human pluripotent stem cells (hPSCs) from culture. Synonyms: STF 31; 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide. Grades: >98%. CAS No. 724741-75-7. Molecular formula: C23H25N3O3S. Mole weight: 423.53. | |
| STF-62247 | STF-62247 is an autophagy inducer that is selectively cytotoxic to VHL-deficient renal cell carcinoma. Synonyms: STF 62247; STF62247; 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine. Grades: >98%. CAS No. 315702-99-9. Molecular formula: C15H13N3S. Mole weight: 267.35. | |
| Strontium chloride | Strontium chloride is a calcium sensing receptor (CaSR) agonist that activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Strontium chloride has been shown to potentiate osteogenic differentiation of mesenchymal stem cells. Synonyms: Strontium chloride (SrCl2); STC-K; Strontium dichloride. Grades: >98%. CAS No. 10476-85-4. Molecular formula: SrCl2. Mole weight: 158.53. | |
| STX-0119 | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes and stem cell-associated genes as well as the induction of apoptosis in one stem-like cell line. STX-0119 may serve as a novel therapeutic compound against GBM-SCs even in temozolomide-resistant GBM patients and has the potential for GBM-SC-specific therapeutics in combination with temozolomide plus radiation therapy. Synonyms: STX 0119; STX0119. Grades: 98%. CAS No. 851095-32-4. Molecular formula: C22H14N4O3. Mole weight: 382.38. | |
| SU11271 | SU11271 is a potent c-MET inhibitor with potential anticancer activity. Synonyms: SU-11271; SU 11271; (Z)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methylene)-5-(indolin-1-ylsulfonyl)indolin-2-one. Grades: 98%. CAS No. 669764-16-3. Molecular formula: C29H31N5O4S. Mole weight: 545.66. | |
| SU11606 | SU11606 is a potent c-MET inhibitor with potential anticancer activity. Synonyms: SU 11606; SU-11606. Grades: 98%. CAS No. 669764-17-4. Molecular formula: C29H33ClN4O4S. Mole weight: 569.12. | |
| SU-11752 | SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited. Synonyms: SU11752; SU11752. Grades: 98%. CAS No. 688036-19-3. Molecular formula: C26H27N3O5S. Mole weight: 493.58. | |
| SU 16f | SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM), displaying > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. It also inhibits VEGF receptor 2. SU 16f has been shown to inhibit proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Synonyms: 3-[2,4-dimethyl-5-[(Z)-(2-oxo-6-phenyl-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; SU-16F. Grades: >98%. CAS No. 251356-45-3. Molecular formula: C24H22N2O3. Mole weight: 386.44. | |
| SU4984 | SU4984 is a protein tyrosine kinase inhibitor used in cancer research with an IC50 of 10-20 μM against fibroblast growth factor receptor 1 (FGFR1). It also inhibits platelet-derived growth factor receptor and insulin receptor. Synonyms: SU-4984; SU 4984; 1-Piperazinecarboxaldehyde, 4-[4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]phenyl]-; 4-{4-[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-1-piperazinecarbaldehyde; 4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde. Grades: ≥95%. CAS No. 186610-89-9. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| SU5607 (IC261) | SU5607 is a potent and selective CK1 inhibitor. It triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Synonyms: IC 261; SU-5607; 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one; (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one. Grades: >98%. CAS No. 186611-52-9. Molecular formula: C18H17NO4. Mole weight: 311.34. | |
| Suberoylanilide hydroxamic acid b-D-glucuronide | Suberoylanilide hydroxamic acid b-D-glucuronide is a highly efficacious inhibitor, aiding in studying cancer, with a distinct focus on histone deacetylases (HDACs). Synonyms: 1-O-[[1,8-Dioxo-8-(phenylamino)octyl]amino]-b-D-Glucopyranuronic acid. CAS No. 863456-50-2. Molecular formula: C20H28N2O9. Mole weight: 440.44. | |
| Succinylcholine Chloride Dihydrate | Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker. Uses: Neuromuscular depolarizing agents. Synonyms: 2,2'-(succinylbis(oxy))bis(N,N,N-trimethylethan-1-aminium) Chloride Dihydrate; Bis(trimethylammonioethyl) succinate chloride. Grades: >98%. CAS No. 6101-15-1. Molecular formula: C14H34Cl2N2O6. Mole weight: 397.34. | |
| Sucrose-6-acetic ester | Sucrose-6-acetic ester, a revolutionary biomedical marvel, emerges as a crucial catalyst for combating an array of afflictions. With its unparalleled potential, this pharmaceutical intermediate orchestrates the synthesis of drugs specifically tailored to tackle inflammatory responses, cancerous growths, and neurodegenerative complexities. Synonyms: SUCROSE-6-ACETIC ESTER; Sucrose-6-aceticester; 63648-81-7; [(2R,3S,4S,5R,6R)-6-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl acetate; Sucrose 6'-Acetate, Technical grade 80%; SCHEMBL891536; 936001-72-8. CAS No. 63648-81-7. Molecular formula: C14H24O12. Mole weight: 384.33. | |
| Sulconazole Nitrate | Sulconazole mononitrate, a broad-spectrum antifungal medication of the imidazole class, can be used to study dermatomycoses, pityriasis versicolor and cutaneous candidiasis. Uses: Antifungal agents. Synonyms: (±)-Sulconazole mononitrate; Sulconazole mononitrate; Exelderm; (±)-1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Mononitrate; 1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Mononitrate; Myk; Sulcosyn; 1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole; 1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate (1:1). Grades: >98%. CAS No. 61318-91-0. Molecular formula: C18H15Cl3N2S.HNO3. Mole weight: 460.76. | |
| Sulfamoxole | Sulfamoxole is a broad-spectrum sulfonamide chemotherapeutic antibacterial agent and dihydropteroate synthetase inhibitor. It can be used to study pediatric infections and to treat bacterial diseases. Uses: Antibacterial. Synonyms: NSC 683535; Oxasulfa; Oxazole; 4-Amino-N-(4,5-dimethyl-2-oxazolyl)benzenesulfonamide; N1-(4,5-dimethyl-2-oxazolyl)sulfanilamide; 2-(p-Aminobenzolsulfonamido)-4,5-dimethyloxazole; 2-Sulfanilamido-4,5-dimethyloxazole; Justamil; Sulfabutin; Sulfadimethyloxazole; Sulfamoxolum; Sulfano; Sulfavigor; Sulfmidil; Sulfono; Sulfune; Sulfuno; Tardamid; Tardamide. Grades: 98%. CAS No. 729-99-7. Molecular formula: C11H13N3O3S. Mole weight: 267.30. | |
| Sulfinpyrazone | Sulfinpyrazone is a uricosuric medication used to treat gout. It inhibits uric acid reabsorption in kidney proximal tubules. It can also used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane. It was developed by Novartis and has been listed. Uses: Sulfinpyrazone is a uricosuric medication used to treat gout. Synonyms: G-28315; G28315; G 28315; Anturane; Sulfinpyrazon; Anturan; Diphenylpyrazone; Anturanil; 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione; NSC 75925. Grades: 98%. CAS No. 57-96-5. Molecular formula: C23H20N2O3S. Mole weight: 404.48. | |
| Sulindac-acyl-b-D-glucuronide | Sulindac-acyl-b-D-glucuronide is a highly intricate biochemical compound standing as a crucial metabolite derived from Sulindac, an esteemed nonsteroidal anti-inflammatory drug (NSAID) lauded for its efficacious research of pain, fever and inflammation. Synonyms: Sulindac-glucuronide; V2VX8U6BY6; UNII-V2VX8U6BY6; 60018-36-2; (2S,3S,4S,5R,6S)-6-(2-((3E)-6-Fluoro-2-(hydroxymethyl)-3-((4-methylsulfinylphenyl)methylene)inden-1-yl)acetyl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; beta-D-Glucopyranuronic acid, 1-(5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetate), (Z)-.BETA.-D-GLUCOPYRANURONIC ACID, 1-(5-FLUORO-2-METHYL-1-((4-(METHYLSULFINYL)PHENYL)METHYLENE)-1H-INDENE-3-ACETATE), (Z)-. CAS No. 60018-36-2. Molecular formula: C26H25FO9S. Mole weight: 532.54. | |
| Sulindac sulfide-acyl-b-D-glucuronide | Sulindac sulfide-acyl-b-D-glucuronide is a highly efficacious compound harnessed in the biomedical sector, manifesting tremendous potential for studying inflammation-associated afflictions like rheumatoid arthritand osteoarthritis. By impeding prostaglandin synthesis, this remarkable merchandise confers commendable anti-inflammatory attributes. Synonyms: Sulindac Sulfide Acyl-beta-D-Glucuronide; 6-[2-[ (3Z) -6-fluoro-2-methyl-3-[ (4-methylsulfanylphenyl) methylidene]inden-1-yl]acetyl]oxy-3, 4, 5-trihydroxyoxane-2-carboxylic acid. CAS No. 59973-78-3. Molecular formula: C26H25FO8S. Mole weight: 516.54. | |
| Sulindac sulfone acyl-b-D-glucuronide | Sulindac sulfone acyl-b-D-glucuronide is an essential metabolite derived from Sulindac is a non-steroidal anti-inflammatory drug (NSAID) employed in the therapeutic research of diverse inflammatory conditions. CAS No. 60018-37-3. Molecular formula: C26H25FO10S. Mole weight: 548.54. | |
| Sulofenur | Sulofenur is a diarylsulfonylurea with potential antineoplastic activity. Sulofenur's antineoplastic mechanism of action is unknown. Check for active clinical trials or closed clinical trials using this agent. Synonyms: LY 186641; LY-186641; LY186641; NSC645012; N-(Indanyl-5-sulfonyl)-N'-(4-chlorophenyl)urea; Sulofenurum; 1-(p-Chlorophenyl)-3-(5-indanylsulfonyl)urea. CAS No. 110311-27-8. Molecular formula: C16H15ClN2O3S. Mole weight: 350.82. | |
| Sulphoquinovosyl diglyceride | | |
| Sunitinib N-glucuronide | | |
| Suprafenacine | Suprafenacine is a destabilizer of microtubules (IC50 value 0.38 μM for microtubule polymerization inhibition) resulting in cell cycle arrest in the G2/M phase and apoptosis of cancer cells. Suprafenacine (SRF) binds to microtubules at the colchicine-binding site and causes the inhibition of cancer cell proliferation. Synonyms: (E)-N'-(4-methylbenzylidene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide; SRF. Grades: 99%. CAS No. 1477482-50-0. Molecular formula: C16H18N4O. Mole weight: 282.34. | |
| Sutimlimab | Sutimlimab is a humanized monoclonal antibody that targets the C1s protein in the classical complement pathway. Sutimlimab has been approved by US FDA for the treatment of adults with cold agglutinin disease (CAD). Synonyms: Enjaymo. CAS No. 2049079-64-1. | |
| SUVN-1507035 | SUVN-1507035 is an agent potentially used for the treatment of anxiety and schizophrenia. Study showed that it has high affinity for mumltiple neural targets, such as 5-HT1A,5-HT2A receptor,D2S,D2L receptor and adrenoreceptor alpha1B. Uses: The potential treatment of anxiety and schizophrenia. Synonyms: SUVN 1507035; SUVN1507035. | |
| SUVN-I-6107 | SUVN-I-6107 is a positive allosteric modulators of muscarinic acetylcholine M1 receptor with high selectivity and activity, which is promisingly used for the treatment of Alzheimer's disease. It has the excellent stability, and exhibits satisfactory safety in mouse study. Uses: The potential treatment of alzheimer's disease. Synonyms: SUVN I 6107. | |
| SW033291 | SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. SW033291 has been shown to promote hematopoietic recovery following murine transplant. Synonyms: SW-033291; SW 033291; 2-(butane-1-sulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine. Grades: >98%. CAS No. 459147-39-8. Molecular formula: C21H20N2OS3. Mole weight: 412.58. | |
| SW155246 | SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1) with IC50 value of 1.2 μM, displaying 30-fold selectivity for inhibition of human DNMT1 versus human or murine DNMT3A or -3B. It was shown to inhibit global methylation in HeLa cells, and reactivate expression of the tumor suppressor gene RASSF1A in A549 cells. Synonyms: 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide. Grades: ≥98%. CAS No. 420092-79-1. Molecular formula: C16H11ClN2O5S. Mole weight: 378.8. | |
| SYN-172B | SYN-172B is an agent used synergistically in combination with colistin in order to decrease MIC of colistin. A study showed that MIC of colistin aganst A. baumannii, Klebsiellapneumoniae and Pseudomonas aeruginosa strains could be reduced to 32mg/mLM from 64 mg/mLM when applied with SYN-172B. Uses: Decrease mic of colistin. Synonyms: SYN 172B; SYN172B. | |
| SYN-87A | SYN-87A is an agent used synergistically in combination with colistin in order to decrease MIC of colistin, 10 mcM of which can significantly reduce MIC of colistin to 0.625 mcg/mL from 128 mcg/mL against A. baumannii Ab23. Uses: Decrease mic of colistin. Synonyms: SYN 87A; SYN 87A. | |
| Syntelin | Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor. Synonyms: [(5-{[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid. Grades: 98%. CAS No. 438481-33-5. Molecular formula: C21H20N6O2S3. Mole weight: 484.61. | |
| (+)-syringaresinol-4,4-bis-O-b-D-glucopyranoside | | |
| T3MG | T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4(IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively). Synonyms: (2R,3S)-2-amino-3-methylpentanedioic acid; (±)-threo-3-Methylglutamic acid; 3MG; threo-3-Methylglutamate. Grades: ≥98% by HPLC. CAS No. 63088-04-0. Molecular formula: C6H11NO4. Mole weight: 161.16. | |
| T817 | T817 is a neuroprotectant. It inhibits oxidative stress and nitric oxide-induced neurotoxicity and acts as a neurotrophic factor. It is a candidate therapeutic agent for Alzheimer's disease. It protects against MPTP-induced neurotoxicity by blocking lipid peroxidation in the SNc. It may be useful for treating neurodegenerative disorders related to oxidative stress, such as Parkinson's disease. It was developed by Toyama Chemical and Fujifilm group together. It is in the clinical phase II. Uses: T817 is a candidate therapeutic agent for alzheimer's disease. it may be useful for treating neurodegenerative disorders related to oxidative stress, such as parkinson's disease. Synonyms: T-817; T 817; Edonerpic; 1-(3-(2-(Benzo[b]thiophen-5-yl)ethoxy)propyl)azetidin-3-ol. Grades: 98%. CAS No. 519187-23-6. Molecular formula: C16H21NO2S. Mole weight: 291.41. | |
| T900607 | T900607 is a pentafluorophenylsulfonamide compound with potential antineoplastic activity. T900607 inhibits tubulin polymerization by binding irreversibly to colchicine binding sites, resulting in cell cycle arrest and apoptosis. Synonyms: T607; T 607; T-607; T 900607; T-900607; N-(4-Methoxy-3-ureidophenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide. CAS No. 261944-52-9. Molecular formula: C14H10F5N3O4S. Mole weight: 411.30. | |
| T 98475 | T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 = 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors, respectively). T 98475 inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys. Synonyms: Thieno[2,3-b]pyridine-5-carboxylic acid, 7-[(2,6-difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-, 1-methylethyl ester; 1-Methylethyl 7-[(2,6-difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate; Isopropyl 3-((benzyl(methyl)amino)methyl)-7-((2,6-difluorophenyl)methyl)-2-(4-(2-methylpropanoylamino)phenyl)-4-oxo-thieno(2,3-b)pyridine-5-carboxylate. Grades: ≥98% by HPLC. CAS No. 199119-18-1. Molecular formula: C37H37F2N3O4S. Mole weight: 657.77. | |
| TA-01 | TA-01 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM and inhibits cardiomyocyte differentiation at 5 μM. Uses: Regulator of cardiomyocyte differentiation. Synonyms: TA 01; TA01. Grades: ≥98%. CAS No. 1784751-18-3. Molecular formula: C20H12F3N3. Mole weight: 351.33. | |
| Tabalumab | Tabalumab is a humanized anti-BAFF (B-cell activating factor) monoclonal antibody developed for the treatment of autoimmune diseases. Synonyms: LY2127399. CAS No. 1143503-67-6. | |
| Tacedinaline | Tacedinaline is a histone deacetylase (HDAC) inhibitor. It can promote hepatic differentiation in hPSCs. Synonyms: CI 994; CI-994; Acetyldinaline; 4-acetamido-N-(2-aminophenyl)benzamide. Grades: >98%. CAS No. 112522-64-2. Molecular formula: C15H15N3O2. Mole weight: 269.304. | |
| Tafasitamab | Tafasitamab is a humanized FC-modified monoclonal antibody that binds to CD19, which is broadly expressed on the surface of B cells. Tafasitamab is indicated for the treatment of B cell malignancies, such as non-Hodgkin's lymphoma (NHL), including diffuse large B cell lymphoma (DLBCL), indolent lymphomas like follicular lymphoma (FL) and marginal zone lymphomas (MZL), as well as chronic lymphocytic leukemia (CLL). Synonyms: XmAb5574; MOR00208; MOR208; Tafasitamab-cxix. CAS No. 1422527-84-1. | |
| TAI-1 | TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. Synonyms: TAI-1; TAI1; TAI 1. Grades: >98%. CAS No. 1334921-03-7. Molecular formula: C24H21N3O3S. Mole weight: 431.51. | |
| TAK-441 | TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway, TAK-441 is also a novel pyrrolo[3,2-c]quinoline-4-one derivative, which chemical structure is shown as the following. TAK-441 showed activity to suppress transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibited tumor growth (treatment/control ratio, 3%) in a mouse medulloblastoma allograft model owing to the improved PK profile based on increased solubility. TAK-441 is currently in clinical trials for the treatment of advanced solid tumors. Synonyms: TAK441; TAK 441. CAS No. 1186231-83-3. Molecular formula: C28H31F3N4O6. Mole weight: 576.57. | |
| TAK-700 | TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result. Synonyms: TAK-700; TAK700; (S/R)-Orteronel; 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide. Grades: >98%. CAS No. 426219-18-3. Molecular formula: C18H17N3O2. Mole weight: 307.35. | |
| TAK-875 Hemihydrate | TAK-875 is a novel, orally available, selective GPR40 agonist. TAK-875 exhibits potent agonist activity and high binding affinity to the human GPR40 receptor with Ki of 38 nM. TAK-875 enhanced glucose-induced insulin secretion in a glucose-dependent manner in both human and rat islets. In rat insulinoma INS-1 833/15 cells, TAK-875 increased intracellular inositol monophosphate and calcium concentration, consistent with activation of the Gqα signaling pathway. In addition, TAK-875 (10 mg/kg, p.o.) significantly augmented plasma insulin levels and reduced fasting hyperglycemia in male Zucker diabetic fatty rats, whereas in fasted normal Sprague-Dawley rats, TAK-875 neither enhanced insulin secretion nor caused hypoglycemia even at 30 mg/kg. TAK-875 improves both postprandial and fasting hyperglycemia with a low risk of hypoglycemia and no evidence of β cell toxicity. TAK-875 significantly improved glycaemic control in patients with type 2 diabetes with minimum risk of hypoglycaemia. Synonyms: Fasiglifam hemihydrate; TAK875 hemihydrate; (3S)-6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy) biphenyl-3-yl)methoxy)-2,3-dihydro-l-benzofuran-3-yl)acetic acid hemihydrate. Grades: 98%. CAS No. 1374598-80-7. Molecular formula: C58H66O15S2. Mole weight: 1067.27. | |
| Taladegib | Taladegib is an inhibitor of Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. It inhibits cell growth and proliferation in tumor cell lines. Synonyms: 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide; LY2940680; LY 2940680; LY-2940680. Grades: >98%. CAS No. 1258861-20-9. Molecular formula: C26H24F4N6O. Mole weight: 512.5. | |
| Talotrexin ammonium | Talotrexin ammonium is the ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. Synonyms: PT-523; PT 523; PT523; NSC 712783; NSC712783; NSC-712783; N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine. CAS No. 648420-92-2. Molecular formula: C28H34N10O6. Mole weight: 590.60. | |
| TAME | TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor. Synonyms: Tosyl-L-Arginine Methyl Este. Grades: >98%. CAS No. 901-47-3. Molecular formula: C14H22N4O4S. Mole weight: 342.41. | |
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