BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SDDC-0001190 | SDDC-0001190 is an inhibitor of dihydrofolate reductase (DHFR) uesd for the treatment of Mycobacterium tuberculosis (MTB). In a previous study, SDDC-0001190 showed high selectivity, low toxicity as well as decent pharmacokinetics with half-life 3.1 h and bioavailability 26%. Uses: The treatment of mycobacterium tuberculosis (mtb). Synonyms: SDDC 0001190; SDDC0001190. |  |
| (S)-(+)-Dimethindene Maleate | The maleate salt form of (S)-(+)-Dimethindene, which has been found to be a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist. Synonyms: 1H-Indene-2-ethanamine, N,N-dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1); 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (+)-, (Z)-2-butenedioate (1:1); N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate; (+)-Dimethindene maleate; (S)-Dimethindene maleate; (S)-N,N-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1H-inden-2-yl)ethan-1-amine maleate. Grades: ≥99% by HPLC. CAS No. 136152-65-3. Molecular formula: C20H24N2.C4H4O4. Mole weight: 408.50. | |
| SecinH3 | SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively. Synonyms: SecinH3; Secin-H3; Secin H3. Grades: >98%. CAS No. 853625-60-2. Molecular formula: C24H20N4O4S. Mole weight: 460.50. | |
| Sedoheptulose-1,7-diphosphate dibarium salt | Sedoheptulose-1,7-diphosphate dibarium salt is an indispensable compound within the biomedical realm, renowned for its role in studying ailments like cancer, diabetes and neurodegenerative disorders. Synonyms: Sedoheptulose-1,7-bisphosphate dibarium salt. CAS No. 815-91-8. Molecular formula: C7H12O13P2 2Ba. Mole weight: 640.76. | |
| Sedoheptulose-1-phosphate | Synonyms: Sedoheptulose 1-phosphate; altro-Heptulose 1-phosphate; 1-O-phosphono-D-altro-hept-2-ulose; D-altro-hept-2-ulose 1-(dihydrogen phosphate); D-Sedoheptulose-1-phosphat; CHEBI:9082; SCHEMBL16634674; C06222; Q27108264; [(3S,4R,5R,6R)-3,4,5,6,7-pentahydroxy-2-oxoheptyl] dihydrogen phosphate. Molecular formula: C7H15O10P. Mole weight: 290.16. | |
| Sedoheptulose anhydride monohydrate | Sedoheptulose anhydride monohydrate, a promising biomedical substance, stands at the forefront of investigating metabolic pathways and unraveling the intricate involvement of sedoheptulose in cellular processes. Synonyms: 2,7-Anhydro-b-D-altro-heptulopyranose; Sedoheptulosan. CAS No. 469-90-9. Molecular formula: C7H12O6 H2O. Mole weight: 210.18. | |
| Selicrelumab | Selicrelumab is an agonistic CD40 monoclonal antibody. Selicrelumab binds to CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth. CAS No. 1622140-49-1. | |
| Semagacestat | Semagacestat is an inhibitor of the γ-secretase complex that blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) from H4 human glioma cells stably overexpressing human wild-type APP into the culture medium. In vitro: blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) without affecting cell viability. In vivo: decreases hippocampal levels of both Aβ42 and Aβ40 at 10 mg/kg (22-23% reduction) and 30 mg/kg (36-41% reduction) and increases β-CTF at 0.3-10 mg/kg in a dose dependent manner with no inhibition on the processing of other γ-secretase substrates, such as Notch, N-cadherin or EphA4, in the brain, but impairs normal cognition in wild-type mice and 3-month-old Tg2576 mice failing to restore cognitive deficits in the Y-maze test. Uses: Gamma secretase inhibitors and modulators. Synonyms: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; LY4501; LY-4501; LY 4501; LY450139; LY-450139; LY 450139; Semagacestat. 425386-60-3. Grades: >98%. CAS No. 425386-60-3. Molecular formula: C19H27N3O4. Mole weight: 361.44. | |
| Semustine | Semustine is a chemotherapy drug similar to lomustine. Semustine alkylates and cross-links DNA thus exhibits cytotoxicity. Uses: Semustine is an alkylating agent and interstrand dna cross linker. anti-cancer chemotherapeutic agents, which are used in the treatment of different types of cancer such as brain tumors, resistant hodgkin's disease, lung cancer and malignant melanoma. Synonyms: N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)nitrosourea; Me-CCNU; Methyl Lomustine; Methyl-CCNU; N'-(4-Methylcyclohexyl)-N-(2-chloroethyl)-N-nitrosourea. Grades: ≥95%. CAS No. 13909-09-6. Molecular formula: C10H18ClN3O2. Mole weight: 247.72. | |
| Sennoside b calciumsalt | Sennoside B Calcium Salt, a compound belonging to anthraquinone family, is an efficacious medicine utilized for the treatment of constipation, with its mechanism of action focusing on the stimulation of the colon to induce contractions, resulting in enhanced stool volume and ultimately, promoting natural bowel movements. By presenting itself in the calcium salt form, the product delivers increased solubility and absorption, ensuring optimum effectiveness throughout the gastrointestinal tract. CAS No. 52730-37-7. Molecular formula: C42H36CaO20. Mole weight: 900.80. | |
| Sennoside C | Aloe-emodin anthrone and rhein anthrone, formed mainly by intraluminal bacterial action, are the true active metabolites of Sennoside C in mice and that both anthrones synergistically exert their purgative effects on mice. Synonyms: [9,9'-Bianthracene]-2-carboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-, (9R,9'R)-rel-; [9,9'-Bianthracene]-2-carboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-, (R*,R*)-; rel-(9R,9'R)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo[9,9'-bianthracene]-2-carboxylic acid; (R*,R*)-5,5'-bis(β-D-Glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-[9,9'-bianthracene]-2-carboxylic Acid. Grades: >98%. CAS No. 37271-16-2. Molecular formula: C42H40O19. Mole weight: 848.76. | |
| Sennoside D | The leaves of Cassia angustifolia. Synonyms: rel-(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo[9,9'-bianthracene]-2-carboxylic Acid; (R*,S*)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-[9,9'-bianthracene]-2-carboxylic Acid. Grades: >98%. CAS No. 37271-17-3. Molecular formula: C42H40O19. Mole weight: 848.76. | |
| SEP-363856 isomer hydrochloride | An R isomer of SEP-363856, a trace amine-associated receptor 1 (TAAR1) agonist used in the research of schizophrenia. Synonyms: (R)-SEP-363856 HCl; (R)-SEP-856 HCl; (R)-SEP-856 hydrochloride. CAS No. 1310422-40-2. Molecular formula: C9H13NOS.HCl. Mole weight: 219.73. | |
| SF1126 | SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84. | |
| SF1670 | SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM. Synonyms: SF1670; SF 1670; SF-1670. Grades: >98%. CAS No. 345630-40-2. Molecular formula: C19H17NO3. Mole weight: 307.34. | |
| SF-331 | SF-331 is one of diaminoaryl-triazinenitrofurylhydrazones with an inhibitory effect on mycobacterium tuberculosis. Uses: Antibacterial agent. Synonyms: SF331; SF 331. | |
| S-Flurbiprofen-acyl-β-D-glucuronide | S-Flurbiprofen-acyl-β-D-glucuronide is an indispensably vital compound in the biomedical industry, exhibiting as an active metabolite of flurbiprofen. This extraordinary product assumes a pivotal role in the vast realm of studying diverse inflammatory ailments and efficaciously managing pain. Grades: > 95%. CAS No. 162992-66-7. Molecular formula: C21H21FO8. Mole weight: 420.39. | |
| SGA360 | SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR) that competitively binds to AhR (IC50 = 3 μM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also exhibits anti-inflammatory activity. Synonyms: 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole. Grades: ≥98%. CAS No. 680611-86-3. Molecular formula: C19H17F3N2O2. Mole weight: 362.4. | |
| SGI-1027 | SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. SGI-1027 may have the potential for use in epigenetic cancer therapy. Synonyms: SGI 1027; SGI1027. Grades: 0.98. CAS No. 1020149-73-8. Molecular formula: C27H23N7O. Mole weight: 461.529. | |
| SGI 1027 dihydrochloride | SGI 1027 is a DNA methyltransferase (DNMT) inhibitor (IC50 values 35 μM and 10 μM for DNMT1 and DNMT3A2/3L, respectively). It was shown to degrade the enzymes and reactivate the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 devoid of significant toxicity in a rat hepatoma (H4IIE) cell line. Synonyms: SGI 1027 dihydrochloride; SGI1027 dihydrochloride; SGI-1027 dihydrochloride; N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide dihydrochloride. Grades: 99%. CAS No. 2108487-01-8. Molecular formula: C27H25Cl2N7O. Mole weight: 534.44. | |
| SGI-110 | SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. Uses: Antineoplastic agents. Synonyms: Guadecitabine; SGI 110; SGI110; 2'-deoxy-5-azacytidylyl-(3'->5')-2'-deoxyguanosine; (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate. Grades: ≥95%. CAS No. 929901-49-5. Molecular formula: C18H24N9O10P. Mole weight: 557.41. | |
| SH-5 | SH-5 is a potent and selective Src kinase inhibitor widely used in biomedical research on multiple diseases, including cancer, osteoporosis and cardiovascular disorders. Synonyms: SH-5, SH 5; SH5; PIA-5; PIA5; PIA 5; L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]. Akt inhibitor II. Grades: 98%. CAS No. 701976-54-7. Molecular formula: C29H59O10P. Mole weight: 598.75. | |
| SH5-07 | SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models. It induces antitumor cell effects against malignant cells harboring constitutively-active Stat3. Synonyms: SH5 07; SH507; SH5-07; 4-[ (4-cyclohexylphenyl) methyl-[2-[methyl- (2, 3, 4, 5, 6-pentafluorophenyl) sulfonylamino]acetyl]amino]-N-hydroxybenzamide; SH-5-07. Grades: >98%. CAS No. 1456632-41-9. Molecular formula: C29H28F5N3O5S. Mole weight: 625.61. | |
| Sialic acid aldolase - Aqueous solution | | |
| Sialic acid aldolase - crystalline | Sialic Acid Aldolase - Crystalline is an exquisitely filtered enzyme, finding profound involvement in the synthetic and catabolic processes of sialic acids, serving as pivotal constituents of glycoproteins and glycolipids. Synonyms: N-Acetylneuraminic acid aldolase; N-Acetylneuraminate lyase; Sialate lyase. | |
| S-Ibuprofen-Acyl-beta-D-Glucuronide | S-Ibuprofen-Acyl-beta-D-Glucuronide is a compound product used for studying the metabolism and pharmacokinetics of S-ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). It is an acyl-glucuronide metabolite of S-ibuprofen generated in the liver. Synonyms: (S)-Ibuprofen-acyl-b-D-glucuronide. Grades: > 95%. CAS No. 98649-76-4. Molecular formula: C19H26O8. Mole weight: 382.40. | |
| Sifalimumab | Sifalimumab is a human monoclonal antibody that binds to and neutralises the majority of IFN-α subtypes. Sifalimumab is a promising treatment for adults with systemic lupus erythematosus (SLE). Synonyms: MEDI-545; MEDI 545; MEDI545. CAS No. 1006877-41-3. | |
| Silatecan | Silatecan (formerly AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. Modifications on the E ring of camptothecin prevent binding of human serum albumin, which prefers the inactive carboxylate form, thereby enhancing the stability of the active lactone structure and resulting in prolonged agent activity. In addition, this agent may radiosensitize tumor cells. Synonyms: AR-67; AR 67; AR67; DB-67; DB 67; DB67; 7-t-Butyldimethylsilyl-10-hydroxycamptothecin. Grades: >98%. CAS No. 220913-32-6. Molecular formula: C26H30N2O5Si. Mole weight: 478.62. | |
| Siltuximab | Siltuximab is a chimeric monoclonal antibody that targets IL-6. Siltuximab has been approved for the treatment of multicentric Castleman's disease (MCD) who do not have human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8) infection. Synonyms: Sylvant; CNTO 328. CAS No. 541502-14-1. | |
| (-)-Silvestrol | A member of flavagline family of natural products from the genus of Aglaia, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior with IC50 of 0.8 nM. Uses: Induces early autophagy and apoptosis in human melanoma cells. Synonyms: Methyl (1R,2R,3S,3aR,8bS)-6-({(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl}oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d] furan-2-carboxylate. Grades: ≥95%. CAS No. 697235-38-4. Molecular formula: C34H38O13. Mole weight: 654.66. | |
| Silvestrol aglycone | Silvestrol aglycone, extracted from Aglaia foveolata, could induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior with IC50 value of 0.8 nM. It is a aglycone with potential anticancer rocaglate. lt induced an apoptotic response, disrupted the mitochondrial trans-membrane potential and caused cytochrome c release into the cytoplasm in vitro. It produced an increase of Bcl-xl phosphorylation with a concomitant increase of bak at the protein level. It selectively inhibit the translation of proteins by a cellular reporter assay. It have similar cytotoxic potency and better ADME characteristics relative to those of silvestrol. Uses: Silvestrol aglycone is a aglycone with potential anticancer rocaglate. Synonyms: (1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester;Methyl (1R,2R,3S,3aR,8bS)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate. Grades: >98 %. CAS No. 960365-65-5. Molecular formula: C27H26O8. Mole weight: 478.49. | |
| Silymarin | Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant. It exhibits in vitro antiviral, antibacterial, antifungal activities and cytotoxicity. Synonyms: Apihepar; Darsil; Flavobion; Karsilin; Laragon. Grades: >80%. CAS No. 65666-07-1. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| SIM010603 | SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis. Although SIM010603 exhibited lower activity in regard to proliferation of NCI-H460, MDA-MB-435, and T241-VEGF-A cells (IC(50) > 1 μmol/l), SIM010603 inhibited tumor growth in these xenograft tumor growth models. SIM010603 reduced tumor MVD in T241-VEGF-A tumor xenograft models and decreased positive signals of CD31, NG2 in MDA-MB-435, and LLC-SW-44 xenograft tumor models. Synonyms: SIM 010603; SIM-010603. CAS No. 1032265-67-0. Molecular formula: C22H25FN4O2. Mole weight: 396.46. | |
| Simmitecan | Simmitecan is a potent topoisomerase I inhibitor, is also a promising water-soluble prodrug of chimmitecan, exhibiting potent antitumor activities both in vitro and in vivo by inhibiting topoisomerase I. Synonyms: Camptothecin L-P. CAS No. 951290-31-6. Molecular formula: C34H38N4O6. Mole weight: 598.69. | |
| Simmitecan Hydrochloride | This active molecular is a topoisomerase I inhibitor originated by ShangHai HaiHe Pharmaceutical. Simmitecan is also a promising water-soluble prodrug of chimmitecan using for the treatment of Solid tumours. In Aug 2016, ShangHai HaiHe Pharmaceutical planed a phase I study in Solid tumours (Monotherapy, Combination therapy) or Colorectal cancer (Combination therapy) in China. Uses: Solid tumours. Synonyms: [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-10-(2-propen-1-yl)-1H-pyrano[3',4':6,7]indolizino[1,2- b]quinolin-9-yl ester, hydrochloride (1:1);951290-31-6 (Simmitecan). Grades: 98%. CAS No. 1247847-78-4. Molecular formula: C34H38N4O6.HCl. Mole weight: 635.16. | |
| Simotaxel | Simotaxel, also known TL-909 and MST-997, is an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models. Simotaxel is a semi-synthetic, orally bioavailable, third-generation taxane derivative and microtubule-stabilizing agent, with potential antineoplastic activity. Synonyms: TL-909; MST-997; TL 909; TL909; MST997; MST 997. CAS No. 791635-59-1. Molecular formula: C46H57NO15S. Mole weight: 896.01. | |
| Simtuzumab | Simtuzumab is a humanized monoclonal antibody directed against LOXL2. Simtuzumab has been used in the research of primary sclerosing cholangitis (PSC). Synonyms: AB 0024; GS 6624. CAS No. 1318075-13-6. | |
| Simvastatin Acyl-β-D-glucuronide | A metabolite of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Uses: The treatment of acute hyperammonemia. Synonyms: 1-[(βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoate] β-D-Glucopyranuronic Acid. Grades: > 95%. CAS No. 1188-38-1. Molecular formula: C31H48O12. Mole weight: 612.71. | |
| Sinigrin | source from white mustard. Uses: Anti-inflammatory, anti-cancer. Synonyms: 2-Propenyl glucosinolate; Allyl glucosinolate potassium; 1-Thio-beta-D-glucopyranose 1-[N-(sulfooxy)-3-butenimidate] potassium salt. Grades: >98%. CAS No. 3952-98-5. Molecular formula: C10H16NO9S2.K. Mole weight: 397.46. | |
| Sintilimab | Sintilimab is a human monoclonal antibody that targets PD-1 and blocks the interaction with its ligands. Sintilimab has been approved for the treatment of Hodgkin's lymphoma. Synonyms: IBI308. CAS No. 2072873-06-2. | |
| SirReal2 | SirReal2 selectively targets SIRT2 and decreases migration as well as invasion in human GC cells. Synonyms: SirReal 2. Grades: 98%. CAS No. 709002-46-0. Molecular formula: C22H20N4OS2. Mole weight: 420.55. | |
| Sitagliptin Carbamoyl Glucuronide | Sitagliptin Carbamoyl Glucuronide is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (R)-Sitagliptin Carbamoyl Glucuronide; 1-[N-[ (1R) -3-[5, 6-dihydro-3- (trifluoromethyl) -1, 2, 4-triazolo[4, 3-a]pyrazin-7 (8H) -yl]-3-oxo-1-[ (2, 4, 5-trifluorophenyl) methyl]propyl]carbamate] β-D-glucopyranuronic acid; Sitagliptin Carbamoyl β-D-Glucuronide. Grades: >90%. CAS No. 940002-59-5. Molecular formula: C23H23F6N5O9. Mole weight: 627.45. | |
| Sivifene | Sivifene gel is the phenylhydrazone 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone formulated as a topical agent with immunomodulating and potential antineoplastic activities. Applied topically as a gel, sivifene may stimulate a local immune response against human papillomavirus (HPV)-induced cervical intraepithelial neoplasia. Synonyms: A 007; A007; A-007; 4-[[2-(2,4-dinitrophenyl)hydrazinyl]-(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one; 4,4'-Dihydroxybenzophenone 2,4-dinitrophenylhydrazone. CAS No. 2675-35-6. Molecular formula: C19H14N4O6. Mole weight: 394.34. | |
| Sivopixant | Sivopixant is a potent and selective P2X3 receptor antagonist. Sivopixant has the potential for the treatment of neuropathic pain and cough. Synonyms: S 600918; S-600918; S600918. CAS No. 2414285-40-6. Molecular formula: C25H22ClN5O5. Mole weight: 507.93. | |
| SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. Synonyms: SJG 136; SJG136; SJG-136; SP-2001; SP2001; SP 2001; BN 2629; BN2629; BN-2629; SG2000; SG 2000; SG-2000; NSC 694501; NSC694501; NSC-694501. Grades: >98.0%. CAS No. 232931-57-6. Molecular formula: C31H32N4O6. Mole weight: 556.61. | |
| SK 216 | SK 216 is an orally available plasminogen activator inhibitor-1 (PAI-1) inhibitor. It inhibits VEGF-induced migration and tube formation in HUVECs, and suppresses angiogenesis in the tumor. SK 216 also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Synonyms: SK-216; SK 216; SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor. 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt. Grades: ≥98% by HPLC. CAS No. 654080-03-2. Molecular formula: C29H29NO6Na2. Mole weight: 533.52. | |
| SKL 2001 | SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive transcription via increasing the intracellular β-catenin protein level, and inhibits the phosphorylation of β-catenin at residues Ser33/37/Thr41 and Ser45. Synonyms: SKL-2001; SKL 2001; SKL2001; Wnt Agonist II; 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide. Grades: 99%. CAS No. 909089-13-0. Molecular formula: C14H14N4O3. Mole weight: 286.29. | |
| SL0101 | SL0101 is a highly specific RSK inhibitor. SL0101 showed improved in vitro biological stability while maintaining specificity for RSK. These results should facilitate the development of RSK inhibitors derived from SL0101 as anticancer agents. Synonyms: SL-0101; SL 0101. CAS No. 77307-50-7. Molecular formula: C25H24O12. Mole weight: 516.455. | |
| SMER28 | SMER28 is a small-molecule modulator of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. It enhances reprogramming of mouse fibroblasts into induced neural stem cell-like cells. Synonyms: N-Allyl-6-bromoquinazolin-4-amine; SMER-28; 6-bromo-N-prop-2-enylquinazolin-4-amine. Grades: >98%. CAS No. 307538-42-7. Molecular formula: C11H10BrN3. Mole weight: 264.12. | |
| SMER 3 | SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30), and also a small molecule enhancer of rapamycin (SMER). SMER 3 directly targets the MET30 subunit and induces the expression of MET genes. SMER 3 inhibits cell proliferation. Synonyms: SMER3; SMER-3; SMER 3; 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one. Grades: ≥98% by HPLC. CAS No. 67200-34-4. Molecular formula: C11H4N4O2. Mole weight: 224.18. | |
| SMIP004 | SMIP004 a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, at low micromolar concentration it upregulated p27 in various prostate cancer cell lines. MTT assay in LNCaP-S14 cells: IC50=1.09 uM. Synonyms: N-(4-butyl-2-methylphenyl)acetamide143360-00-3N1-(4-butyl-2-methylphenyl)acetamideSMIP004; SMIP-004; SMIP 004. Acetamide , N- (4-butyl-2- methyl phenyl) -2- methyl -4-butylacetanilide N- (4-butyl-2- methyl phenyl) acetamide ZINC02565087Maybridge1_000068ACMC-1C0QFAC1MCN19MixCom1_0. CAS No. 143360-00-3. Molecular formula: C13H19NO. Mole weight: 205.15. | |
| SN-23862 | SN-23862 is a bioreductive agent with potential anticancer activity. SN-23862 is analogue of CB-1954, a dinitrobenzamide aziridine with nitrogen mustard. SN-23862 is also a prodrug that is activated by enzymatic nitroreduction in tumor. Synonyms: SN23862; SN 23862; 5-(N,N-Bis(2-chloroethyl)amino)-2,4-dinitrobenzamide. CAS No. 142439-61-0. Molecular formula: C11H12Cl2N4O5. Mole weight: 351.14. | |
| SN-28049 | SN-28049SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049. Synonyms: SN28049; SN 28049; N-(2-(dimethylamino)ethyl)-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carboxamide. CAS No. 492472-30-7. Molecular formula: C19H22N4O2. Mole weight: 338.41. | |
| SN-38 Glucuronide | A metabolite of Irinotecan. Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 121080-63-5. Molecular formula: C28H28N2O11. Mole weight: 568.53. | |
| SNAP 398299 | SNAP 398299 is a potent and selective GAL3 antagonist (Ki = 5 nM) displaying > 100-fold selectively for GAL3 over GAL1, GAL2, adrenergic α1a and dopamine D5 receptors. SNAP 398299 exhibits anxiolytic- and antidepressant-like effects in vivo. Synonyms: SNAP 398299; SNAP398299; SNAP-398299; 1,3-Dihydro-1-[3-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one; 1-[3-(2-pyrrolidin-1-ylethoxy)phenyl]-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one. Grades: ≥97% by HPLC. CAS No. 903878-06-8. Molecular formula: C27H24F3N3O2. Mole weight: 479.49. | |
| (S)-nitro-Blebbistatin | (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. Synonyms: S-(-)-7-Desmethyl-8-nitro Blebbistatin; (3aS)-3a-hydroxy-7-nitro-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one. Grades: ≥98%. CAS No. 856925-75-2. Molecular formula: C17H13N3O4. Mole weight: 323.3. | |
| SNS-314 | SNS-314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Synonyms: SNS314; SNS 314; N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]Urea. Grades: >98%. CAS No. 1057249-41-8. Molecular formula: C18H15ClN6OS2. Mole weight: 430.93. | |
| (S)-O-[2-(Acetylamino)-3-O-benzoyl-2-deoxy-4,6-O-benzylidene-α-D-galactopyranosyl]-N-9-Fmoc-L-serine Phenacyl Ester | (S)-O-[2-(Acetylamino)-3-O-benzoyl-2-deoxy-4,6-O-benzylidene-α-D-galactopyranosyl]-N-9-Fmoc-L-serine Phenacyl Ester is a biochemical compound applied extensively in biomedical research as a key reagent in synthetic organic chemistry. It is vital in research to synthesize drugs for the treatment of various diseases such as cancer and infectious diseases. Uses: Intermediate in the preparation of stn epitope. Synonyms: (S)-O-[2-(Acetylamino)-3-O-benzoyl-2-deoxy-4,6-O-(phenylmethylene)-α-D-galactopyranosyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine 2-Oxo-2-phenylethyl Ester. CAS No. 171973-67-4. Molecular formula: C48H44N2O12. Mole weight: 840.87. | |
| Soblidotin | Soblidotin (TZT-1027) is a dolastatin-10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. TZT-1027 showed increased antitumor activity when combined with gemcitabine in animal models. Uses: Antineoplastic agents. Synonyms: Auristatin PE; NSC-654663; NSC 654663; NSC654663; TZT-1027; TZT 1027; TZT1027. Grades: 99%. CAS No. 149606-27-9. Molecular formula: C39H67N5O6. Mole weight: 701.99. | |
| Sodium butyrate | Sodium butyrate is a HDAC inhibitor. It can be used in reprogramming of somatic cells into human induced pluripotent stem cells via induction of the miR302/367 cluster. Uses: Methyl benzo[d]oxazole-4-carboxylate (cas# 128156-54-7) is a useful research chemical. Synonyms: sodium;butanoate. Grades: > 98 %. CAS No. 156-54-7. Molecular formula: C4H7NaO2. Mole weight: 110.09. | |
| Sodium-D-glucuronate hydrate | Sodium-D-glucuronate hydrate is an innovative compound proficiently employed in the research of osteoporosand hepatic disorders. It serves as an inherent forerunner in glycosaminoglycans synthesis. Synonyms: D-Glucuronic acid sodium salt; D-Glucuronic acid sodium salt monohydrate. CAS No. 207300-70-7. Molecular formula: C6H9NaO7 H2O. Mole weight: 234.14. | |
| Sodium Monofluorophosphate | Cas No. 10163-15-2. | |
| Sofituzumab | Sofituzumab is an anti-MUC16 monoclonal antibody that can be used in ADC synthesis. Synonyms: MMUC 1206A; MMUC-1206A; MMUC1206A. CAS No. 1615692-28-8. | |
| Solcitinib | Solcitinib is an orally available JAK1 inhibitor with an IC50 of 9.8 nM. It has been investigated for the treatment of psoriasis, systemic lupus erythematosus, and ulcerative colitis. Synonyms: GSK 2586184; GSK-2586184; GLPG-0778; GLPG 0778; N-[5-[4-(3,3-dimethylazetidine-1-carbonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide. Grades: >98%. CAS No. 1206163-45-2. Molecular formula: C22H23N5O2. Mole weight: 389.459. | |
| Somatostatin monoacetate | Somatostatin monoacetate is a peptide hormone. It regulates the endocrine system and affects neurotransmission and cell proliferation by interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. It inhibits insulin and glucagon secretion. Synonyms: Somatostatin (sheep), monoacetate (salt); H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH.CH3CO2H (Disulfide bridge: Cys3-Cys14); L-alanyl-glycyl-L-cysteinyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine (3->14)-disulfide acetic acid. Grades: 98%. CAS No. 54472-66-1. Molecular formula: C78H108N18O21S2. Mole weight: 1697.95. | |
| Sonelokimab | Sonelokimab is a novel trivalent nanobody comprised of monovalent camelid-derived nanobodies specific to human interleukin IL-17A, IL-17F, and human serum albumin. Sonelokimab has been used in the research of plaque psoriasis. Synonyms: ALX 0761; M 1095. CAS No. 1414386-05-2. | |
| Sotigalimab | Sotigalimab is a humanized monoclonal antibody targeting CD40. Sotigalimab has been used in the research of pancreatic adenocarcinoma. Synonyms: APX005M. CAS No. 2305607-45-6. | |
| SP600125 | SP-600125 is a specific JNK inhibitor. SP600125 kills p53-deficient cells more efficiently than their p53-proficient counterparts, in vitro. Similar observations were obtained in vivo, in mice carrying p53-deficient and -proficient human xenografts. Synonyms: SP600125; SP 600125; SP-600125. Grades: 0.98. CAS No. 129-56-6. Molecular formula: C14H8N2O. Mole weight: 220.231. | |
| Spesolimab | Spesolimab is a monoclonal antibody that targets interleukin-36 receptor (IL-36R). Spesolimab has been approved for the treatment of generalized pustular psoriasis (GPP) flares in adults. Synonyms: Spevigo. CAS No. 2097104-58-8. | |
| Splitomicin | Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. Synonyms: Splitomycin; 2-Hydroxy-1-Naphthalenepropionic Acid δ-Lactone; 2-Hydroxy-1-Naphthalenepropanoic Acid δ-Lactone; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1H-benzo[f]chromen-3(2H)-one; 1H,2H,3H-Naphtho[2,1-b]pyran-3-one; 1,2-Dihydro-3H-benzo[f]chromen-3-one. Grades: ≥98%. CAS No. 5690-3-9. Molecular formula: C13H10O2. Mole weight: 198.22. | |
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