BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Tanomastat | Tanomastat is a biphenyl matrix metalloproteinase (MMP) inhibitor (MMPI) with potential antineoplastic activity. Tanomastat inhibits MMP-2, MMP-3, and MMP-9, inhibiting extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis. MMPs consist of at least 18 zinc-containing endo-proteinases that are capable of degrading collagen and proteoglycan. Uses: Antineoplastic agents. Synonyms: BAY 12-9566, BAY12-9566, BAY-12-9566, BAY 129566, BAY129566, BAY-129566, Tanomastat; (S)-4'-Chloro-g-oxo-a-[(phenylthio)methyl][1,1'-biphenyl]-4-butanoic Acid. Grades: >98%. CAS No. 179545-77-8. Molecular formula: C23H19ClO3S. Mole weight: 410.91. |  |
| TAPI-1 | TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. Synonyms: TAPI 1; TAPI1; (2S,2S)-TAPI-1. Grades: >98%. CAS No. 171235-71-5. Molecular formula: C26H37N5O5. Mole weight: 499.60. | |
| TAS-108 | TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108. Synonyms: TAS108; TAS 108; SR16234; SR 16234; SR-16234; (7alpha)-21-(4-((Diethylamino)methyl)-2-methoxyphenoxy)-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate. Grades: >98%. CAS No. 229634-98-4. Molecular formula: C39H55NO10. Mole weight: 697.86. | |
| Tasidotin hydrochloride | Tasidotin, also know as ILX-651, is an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) of 72 nmol/L in the absence of detectable effects on spindle microtubule polymer mass. Tasidotin inhibited the polymerization of purified tubulin into microtubules weakly (IC(50) approximately 30 micromol/L). However, it strongly suppressed the dynamic instability behavior of the microtubules at their plus ends at concentrations approximately 5 to 10 times below those required to inhibit polymerization. Synonyms: ILX 651; ILX651; ILX-651. CAS No. 623174-20-9. Molecular formula: C32H59ClN6O5. Mole weight: 643.31. | |
| TASIN-1 | TASIN-1 is an inhibitor of adenomatous polyposis coli (APC) that kills colorectal cancer cells that express APC by reducing cellular cholesterol levels. It also inhibits AKT activity through a cholesterol-dependent manner. Synonyms: 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine. Grades: ≥98%. CAS No. 792927-06-1. Molecular formula: C18H28N2O3S. Mole weight: 352.5. | |
| Tasisulam | Tasisulam is a small molecule anticancer drug that induces apoptosis through intrinsic pathways. It leads to the release of cytochrome c and caspase-dependent cell death. Tasisulam can inhibit the process of mitosis and induce vascular normalization. Synonyms: LY 573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide. Grades: >98%. CAS No. 519055-62-0. Molecular formula: C11H6BrCl2NO3S2. Mole weight: 415.11. | |
| Tat-beclin 1 | Tat-beclin 1 is a region of the autophagy protein, beclin 1, binding to HIV-1 Nef and inducing autophagy. Synonyms: Tat-BECN1. CAS No. 1423821-88-8. Molecular formula: C164H251N57O45. Mole weight: 3741.1. | |
| Taxicatin | Taxicatin is a remarkable cytotoxic compound obtained from Taxus brevifolia, aiding in the research of malignant neoplasms. Diversely employed in the research of breast, lung and ovarian cancers, Taxicatin effectively impedes cellular mitosand hampers aberrant tumor cells proliferation. Synonyms: 3,5-Dimethoxyphenyl-beta-D-glucopyranoside. CAS No. 90-71-1. Molecular formula: C14H20O8. Mole weight: 316.3. | |
| TBB | TBB is a potent protein kinase CK2 inhibitor, which induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Synonyms: 4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634; NSC231634; NSC-231634; TBBt. Grades: 0.98. CAS No. 17374-26-4. Molecular formula: C6HBr4N3. Mole weight: 434.711. | |
| TBCA | TBCA is a potent CK2 inhibitor. TBCA inhibits CK2 five times more efficiently than TBB without having any comparable effect on DYRK1 a (IC50 24.5 microM) or on a panel of 28 protein kinases. The usefulness of TBCA for cellular studies has been validated by showing that it reduces the viability of Jurkat cells more efficiently than TBB through enhancement of apoptosis. Synonyms: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic Acid; Casein Kinase II Inhibitor III; (2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid; (2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid; Tetrabromocinnamic acid. Grades: ≥98%. CAS No. 934358-00-6. Molecular formula: C9H4Br4O2. Mole weight: 463.74. | |
| TC ASK 10 | TC ASK 10 is a potent and orally bioactive ASK1 inhibitor (IC50 = 14 nM) with selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 > 10 μM). TC ASK 10 blocks downstream JNK1/p38 phosphorylation in cells. Synonyms: 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride; ASK1 Inhibitor 10. Grades: ≥98% by HPLC. CAS No. 1005775-56-3. Molecular formula: C21H21N5O.2HCl. Mole weight: 432.35. | |
| TC-DAPK 6 | An oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 μM. Synonyms: TC-DAPK 6; TC DAPK 6; TCDAPK6; DAPK Inhibitor; T6908224; T-6908224; T 6908224. Grades: >98%. CAS No. 315694-89-4. Molecular formula: C17H12N2O2. Mole weight: 276.29. | |
| TC-G-1008 | TC-G-1008, also known as GPR39-C3, is a potent and orally available GPR39 agonist (EC50= 0.4 and 0.8 nM for rat and human receptors respectively) with great selectivity for GPR39 over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Synonyms: GPR39-C3, GPR39C3, GPR39 C3, TC-G-1008, TC-G1008, TC-G 1008, TCG-1008, TCG1008, TCG 1008; N- [3-chloro-4- [ [ [2- (methylamino) -6-pyridin-2-ylpyrimidin-4-yl] amino] methyl] phenyl] methanesulfonamide; GPR39-C3; N- (3-chloro-4- ( ( (2- (methylamino) -6- (2-pyridinyl) -4-pyrimidinyl) amino) methyl) phenyl) methanesulfonamide; TC-G 1008. CAS No. 1621175-65-2. Molecular formula: C18H19ClN6O2S. Mole weight: 418.9. | |
| TCS JNK 6o | TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor with Kis of 2, 4 and 52 nM for JNK1, JNK2 and JNK3, respectively, and IC50s of 45 and 160 nM for JNK1 and JNK2, respectively. It shows >1000-fold selectivity over other kinases, including ERK2 and p38. It can inhibit apoptosis, caspase cleavage and cytochrome C release. Synonyms: JNK Inhibitor VIII; N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide; Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-. Grades: ≥98% by HPLC. CAS No. 894804-07-0. Molecular formula: C18H20N4O4. Mole weight: 356.38. | |
| Teglarinad chloride | Teglarinad chloride, also known as GMX1777, is a water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. Uses: Antitumor agent. Synonyms: apoptosis inducer GMX1777; GMX 1777; GMX-1777; UNII-D6V5QYX9MZ; 1- [ [ [ [2- [2- [2- [2-Methoxyethoxy] ethoxy] ethoxy] ethoxy] carbonyl] oxy] methyl] -4- [N'-cyano-N''- [6- [4-chlorophenoxy] hexyl] guanidino] pyridinium chloride. CAS No. 432037-57-5. Molecular formula: C30H43Cl2N5O8. Mole weight: 672.61. | |
| Telcagepant | Telcagepant is a calcitonin gene-related peptide(CGRP) receptor antagonist under development for the acute treatment and prevention of migraine. It is a highly potent, selective, and orally bioavailable antagonist of the human (K(I) = 0.77 nM) and rhesus (K(I) = 1.2 nM) CGRP receptors, which displays 1500-fold lower affinity for the canine and rat receptors as determined via (125)I-human CGRP competition binding assays in vitro. It displayed moderate clearance (14-20 ml min(-1) kg(-1)) in monkeys, while oral bioavailability was 6%. It was developed by Merck & Co. It was found to have equal potency to rizatriptan and zolmitriptan in two Phase III clinical trials in the acute treatment of migraine. But the company has now terminated development of the drug. Uses: Telcagepant is used to acute treatment and prevention of migraine. Synonyms: MK 0974; MK0974; MK-0974; N-[(3R,6S)-6-(2,3-Difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxamide;N-(6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-B)pyridin-1-yl)piperidine-1-carboxamide. Grades: 95%. CAS No. 781649-09-0. Molecular formula: C26H27F5N6O3. Mole weight: 566.53. | |
| Telmisartan Acyl-β-D-glucuronide | Telmisartan Acyl-β-D-glucuronide is one of Telmisartan metabolites. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: 1-[4'-[(1',4-Dimethyl-2-propyl[2',6-bi-1H-benzimidazol]-1-yl)methyl][1,1'-biphenyl]-2-carboxylate] β-D-Glucopyranuronic Acid; Telmisartan Glucuronide; Telmisartan acyl glucuronide; 4'-[[2-Propyl-4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-1H-benzimidazole-1-yl]methyl]-1,1'-biphenyl-2-carboxylic acid beta-D-glucopyranuronosyl ester. Grades: ≥95%. CAS No. 250780-40-6. Molecular formula: C39H38N4O8. Mole weight: 690.74. | |
| Telmisartan-D3-acyl-b-D-glucuronide | | |
| Telotristat Etiprate (LX 1606 Hippurate) | Cas No. 11137608-69-5. | |
| Teloxantrone | Teloxantrone, an anthrapyrazole antineoplastic antibiotic, inhibits DNA replication and repair, as well as RNA and protein, by intercalating into DNA and interacts with topoisomerase II. Synonyms: CI-937; CI 937; CI937; DUP-937; DUP 937; DUP937. CAS No. 91441-48-4. Molecular formula: C21H25N5O4. Mole weight: 411.46. | |
| Tempol | Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Synonyms: 4-Hydroxy-TEMPO; NSC-142784, OT-674, NSC142784, OT674, NSC 142784, OT 674, Tempol. Grades: >98%. CAS No. 2226-96-2. Molecular formula: C9H18NO2. Mole weight: 172.24. | |
| Tenatoprazole | Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Synonyms: TU-199; TU 199; TU199; Tenatoprazole; Ulsacare; Protop. Grades: >98%. CAS No. 113712-98-4. Molecular formula: C16H18N4O3S. Mole weight: 346.40. | |
| Tenifatecan | Tenifatecan, also known as SN2310, is an injectable emulsion composed of 7-ethyl-10-hydroxycamptothecin (SN-38) conjugate with vitamin E through a succinate linker. SN-38 is the active metabolite of irinotecan. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. SN2310 Injectable Emulsion is being developed with the objective of demonstrating improved anti-tumor activity as a result of increased exposure to SN-38 based on a longer half-life. Synonyms: SN 2300; SN2300; SN-2300; BEL2310; BEL 2310; BEL-2310. CAS No. 850728-17-5. Molecular formula: C53H68N2O8. Mole weight: 861.12. | |
| Teniposide | Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Uses: Antineoplastic agents; enzyme inhibitors; nucleic acid synthesis inhibitors. Synonyms: NSC-122819; NSC 122819; NSC122819; VM26; VM-26; VM 26; HSDB 6546; HSDB6546; HSDB-6546; CCRIS 2058. Brand name: Vumon; Vehem. Abbreviations: EPT; PTG. Grades: >98%. CAS No. 29767-20-2. Molecular formula: C32H32O13S. Mole weight: 656.65. | |
| Teplizumab | Teplizumab is a humanized anti-CD3 monoclonal antibody indicated to delay the onset of Stage 3 type 1 diabetes in patients with Stage 2 type 1 diabetes. Synonyms: MGA-031; PRV-031; Tzield. CAS No. 876387-05-2. | |
| Teprotumumab | Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab has been approved for the treatment of thyroid eye disease. Synonyms: Tepezza. CAS No. 1036734-93-6. | |
| Terameprocol | Terameprocol, a semi-synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In virally-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular endothelial growth factor (VEGF), which are overexpressed in a variety of cancers. By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis. Synonyms: meso-Tetra-O-methylnordihydroguaiaretic acid; EM-1421; EM1421; EM 1421; rel-4,4'-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(1,2-dimethoxybenzene); TMNDGA. Grades: >98%. CAS No. 24150-24-1. Molecular formula: C22H30O4. Mole weight: 358.47. | |
| Teroxirone | Teroxirone is a triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication. Uses: Antineoplastic agents. Synonyms: Henkel's Compound; alpha-TGI; alpha-triglycidyl isocyanurate. CAS No. 59653-73-5. Molecular formula: C12H15N3O6. Mole weight: 297.27. | |
| tert-Amyl 2-acetamido-2-deoxy-b-D-glucopyranoside | Tert-Amyl 2-acetamido-2-deoxy-b-D-glucopyranoside is an invaluable chemical compound that finds frequent use in biomedical applications as a glycosylation inhibitor. It serves as an excellent candidate for studying the intricacies of glycoprotein processing within cells and its impact on protein function. Given its remarkable potential to shed light on diverse diseases, such as cancer and neurodegenerative disorders, its significance in the research community cannot be overstated. CAS No. 262849-66-1. Molecular formula: C13H25NO6. Mole weight: 291.34. | |
| tert-Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside | tert-Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside, an intriguing biomedicine compound, exhibits remarkable potential in the scientific realm. Notably, this innovative agent showcases exceptional efficacy in combatting an array of diseases by exerting its prowess against insidious bacterial and viral infections. Its distinctive molecular arrangement unleashes a targeted assault on pathogenic enzymes, effectively thwarting their growth and activity. Synonyms: tert-Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside;TERT-AMYL 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-BETA-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, 1,1-dimethylpropyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate; [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-(2-methylbutan-2-yloxy)oxan-2-yl]methyl acetate. CAS No. 262849-65-0. Molecular formula: C19H31NO9. Mole weight: 417.45. | |
| tert-Butyl 2-acetamido-2-deoxy-b-D-glucopyranoside | tert-Butyl 2-acetamido-2-deoxy-b-D-glucopyranoside, a fascinating compound, finds profound utility in the ever-evolving biomedical sphere. This compound's multifaceted characteristics empower its deployment in synthesizing glycosyl conjugates and glycosaminoglycans - pivotal agents in orchestrating intricate biological processes. Synonyms: tert-Butyl 2-acetamido-2-deoxy-b-D-glucopyranoside; 262849-69-4; N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(2-methylpropan-2-yl)oxy]oxan-3-yl]acetamide; AKOS001746048; W-202120; N-[(2S,3R,4R,5S,6R)-2-(TERT-BUTOXY)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-3-YL]ACETAMIDE. CAS No. 262849-69-4. Molecular formula: C12H23NO6. Mole weight: 277.31. | |
| tert-Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside | tert-Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside, a critical component utilized in the field of biomedicine for combating a diverse range of illnesses, demands our attention. It showcases extraordinary characteristics with its powerful antimicrobial attributes, rendering it an efficacious contender in the battle against bacterial infections. Notably, it exhibits exceptional potency against notorious strains like Staphylococcus aureus and Escherichia coli. Synonyms: tert-Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside; [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-[(2-methylpropan-2-yl)oxy]oxan-2-yl]methyl acetate; DTXSID701132863; AKOS002687923; W-203787; beta-D-Glucopyranoside, 1,1-dimethylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate. CAS No. 7772-86-3. Molecular formula: C18H29NO9. Mole weight: 403.42. | |
| tert-Butyl 2-deoxy-L-ribopyranoside | tert-Butyl 2-deoxy-L-ribopyranoside is a versatile and indispensable compound tool extensively employed for the research of a myriad of intricate ailments encompassing malignant neoplasms, metabolic disorders encompassing diabetes mellitus, as well as insidious viral infections of multifarious etiologies. Synonyms: (3S,4R)-6-[(2-methylpropan-2-yl)oxy]oxane-3,4-diol; TERT-BUTYL2-DEOXY-L-RIBOPYRANOSIDE. Molecular formula: C9H18O4. Mole weight: 190.24. | |
| tert-Butyl b-D-glucopyranoside | tert-Butyl b-D-glucopyranoside, a prevalent chemical compound in biomedicine, exhibits multifaceted roles of paramount importance. It functions as a non-reducing carbohydrate in diverse research investigations and pharmaceutical applications. This compound serves as a pivotal glucose source and finds widespread usage in vaccine and biologics manufacture. Moreover, its significance shines through in the examination of cell-surface glycosylation patterns and the glycosidase activities that govern therapeutic interventions. Synonyms: tert-Butyl b-D-glucopyranoside; 29074-04-2; T-BUTYL D-GLUCOSIDE; (2R,3S,4S,5R)-2-(hydroxymethyl)-6-[(2-methylpropan-2-yl)oxy]oxane-3,4,5-triol; SCHEMBL2624407. CAS No. 29074-04-2. Molecular formula: C10H20O6. Mole weight: 236.26. | |
| Tesetaxel | Tesetaxel is a semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Synonyms: DJ-927; DJ 927; DJ927. CAS No. 333754-36-2. Molecular formula: C46H60FN3O13. Mole weight: 881.99. | |
| Tetomilast | Tetomilast, a thiazol derivative, has been found to be a PDE-4 inhibitor that could be effective against inflammatory bowel disease by restraining the formation of proinflammatory cytokines and it is still under Phase II trial for chronic obstructive pulmonary disease by Otsuka Pharmaceutical. Synonyms: OPC-6535; OPC 6535; OPC6535; 6-(2-(3,4-Diethoxyphenyl)thiazol-4-yl)picolinic acid. Grades: 98%. CAS No. 145739-56-6. Molecular formula: C19H18N2O4S. Mole weight: 370.42. | |
| Tetracycline 10-O-b-D-galactopyranoside | Tetracycline 10-O-b-D-galactopyranoside, an artificially derived compound, plays a pivotal role in biomedicine, being highly effective against bacterial infections. Through the process of prodrug conversion, it metamorphoses into tetracycline, an extensive-ranging antibiotic. Synonyms: TETRACYCLINE 10-O-B-D-GALACTOPYRANOSIDE; 319426-63-6; (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-10-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,4a,5,5a-tetrahydrotetracene-2-carboxamide; DTXSID50716366; Tetracycline 10-O- -D-Galactopyranoside; Tetracycline 10-O-beta-D-galactopyranoside; M03610; W-202317; (4S,4aS,5aS,6S,12aR)-4-(Dimethylamino)-10-(beta-D-galactopyranosyloxy)-1,6,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboxamide. CAS No. 319426-63-6. Molecular formula: C28H34N2O13. Mole weight: 606.58. | |
| Tetra-O-acetyl-2-acetamido-2-deoxy-b-D-mannose | Tetra-O-acetyl-2-acetamido-2-deoxy-b-D-mannose is an immensely powerful biomolecule lauded for its immense potential applicability in the research of diverse afflictions particularly rooted in the intricate domain of glycosylation. | |
| TFB-TBOA | TFB-TBOA is a glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 = 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3, respectively). TFB-TBOA exhibits no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. TFB-TBOA attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Synonyms: (3S) -3-[[3-[[4- (Trifluoromethyl) benzoyl]amino]phenyl]methoxy]-L-aspartic acid; (2S, 3S) -2-amino-3- [ [3- [ [4- (trifluoromethyl) benzoyl] amino] phenyl] methoxy] butanedioic acid. Grades: ≥98% by HPLC. CAS No. 480439-73-4. Molecular formula: C19H17F3N2O6. Mole weight: 426.35. | |
| TG003 | TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. Synonyms: (E/Z)-TG003; TG 003; TG-003; 1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2(3H)-ylidene)acetone; 2-Propanone, 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-; 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone. Grades: >98%. CAS No. 300801-52-9. Molecular formula: C13H15NO2S. Mole weight: 249.33. | |
| TG100713 | TG100713 is an inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation. Synonyms: TG 100713; TG-100713; 3-(2,4-diamino-pteridin-6-yl)-phenol. Grades: 99%. CAS No. 925705-73-3. Molecular formula: C12H10N6O. Mole weight: 254.25. | |
| TG101209 | TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209, when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. Synonyms: TG101209; TG-101209; TG 101209. Grades: 0.98. CAS No. 936091-14-4. Molecular formula: C26H35N7O2S. Mole weight: 509.67. | |
| TGR5 | A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222. | |
| TH287 | TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. Synonyms: TH 287; TH-287. Grades: 98%. CAS No. 1609960-30-6. Molecular formula: C11H10Cl2N4. Mole weight: 269.13. | |
| TH287 hydrochloride | TH287 hydrochloride, with potent anti-cancer property, is a novel inhibitor of the MTH1 protein which is required for cancer cell survival and is overexpressed in cancer cells. IC50: MTH1 (NUDT1)= 0.8 nM. Synonyms: 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine;hydrochloride; TH287 (hydrochloride); TH 287 hydrochloride; TH-287 hydrochloride. CAS No. 1638211-05-8. Molecular formula: C11H11Cl3N4. Mole weight: 305.59. | |
| TH588 | TH588 selectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells. Synonyms: TH588; TH 588; TH-588. Grades: >98%. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. | |
| TH588 hydrochloride | TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for cancer cell survival and is overexpressed in cancer cells. Synonyms: 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;hydrochloride; TH588 (hydrochloride); TH-588 hydrochloride; TH 588 hydrochloride; N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride; 1640282-30-9. CAS No. 1640282-30-9. Molecular formula: C13H13Cl3N4. Mole weight: 331.63. | |
| TH9402 | TH9402, a 4,5-dibromorhodamine derivative, is a novel photo-sensitizer. PDT using TH9402 triggers a caspase-dependent intrinsic apoptotic pathway. TH9402 offers an excellent potential as an ex vivo photodynamic purging agent for autologous transplantation in MM and BC treatment. Synonyms: TH9402; TH-9402; TH 9402; Xanthylium, 3,6-diamino-4,5-dibromo-9-[2-(methoxycarbonyl)phenyl]-, chloride (1:1). CAS No. 174230-05-8. Molecular formula: C21H15Br2ClN2O3. Mole weight: 538.62. | |
| Thalicarpine | Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Synonyms: Thaliblastine; Taliblastine; Taliblastin; NY-IV-34-1; NSC-68075; NSC 68075; (S)-9-(2-(((S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4,5-dimethoxyphenoxy)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. CAS No. 5373-42-2. Molecular formula: C41H48N2O8. Mole weight: 696.83. | |
| Theralizumab | Theralizumab is an anti-CD28 monoclonal antibody that has been developed as a potential immunomodulatory drug for the treatment of autoimmune diseases. Theralizumab activates T cells by binding to CD28 receptor irrespective of T-cell receptor activation. Synonyms: TGN1412; CD28-SuperMAB; TAB08. CAS No. 906068-56-2. | |
| Thevetoside | Cas No. 117743-32-5. | |
| Thiamine galactoside | Thiamine Galactoside is an intriguing compound aiding in studying amidst thiamine deficiency diseases. Synonyms: Thiaminegalactoside. CAS No. 260370-52-3. Molecular formula: C18H27O6N4S C2H3O2. Mole weight: 486.54. | |
| Thiarabine | thiarabine is a analog of antimetabolite cytarabine (ara-C), with potential antineoplastic activity. Upon administration, thiarabine (T-araC) is phosphorylated to the triphosphate form T-araCTP and competes with cytidine for incorporation into DNA. This results in an inhibition of DNA replication and RNA synthesis, chain termination and may eventually decrease tumor cell proliferation. Compared to ara-C, T-araC appears to have a longer half-life and has a higher efficacy. Synonyms: OSI-7836; 2(1H)-Pyrimidinone, 4-amino-1-(4-thio-beta-D-arabinofuranosyl)-; Thio-Cytarabine; 4'-Thioaracytidine; 4'-Thio-ara-C; 4'-Thio-1-beta-D-arabinofuranosylcytosine; 4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone. Grades: ≥95%. CAS No. 26599-17-7. Molecular formula: C9H13N3O4S. Mole weight: 259.28. | |
| Thiocolchicine | Thiocolchicine is a potent tubulin polymerization and microtubule assembly inhibitor, a axonal cytoskeleton modulator and apoptosis inducer. Structurally, thiocolchicine is a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety. Thiocolchicine was shown to bind with high affinity to the colchicine site on tubulin. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors. Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 10-Thio-colchicine; 10-Demethoxy-10-(methylthio)colchicine; NSC 186301. Grades: 98%. CAS No. 2730-71-4. Molecular formula: C22H25NO5S. Mole weight: 415.50. | |
| Thioglucosides | | |
| Thioridazine | Thioridazine is an inhibitor of CYP1A2 and CYP3A2. It is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. It was developed by Novartis and has been listed, but it was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias, however, generic versions are available in the US. Uses: Thioridazine was previously widely used in the treatment of schizophrenia and psychosis. Synonyms: 10-((1-Methyl-2-piperidyl)ethyl)-2-(methylthio)-phenothiazin;10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine;10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-; Meleril; Mellaril; Melleril; Sonapax; Aldazine. Grades: 98%. CAS No. 50-52-2. Molecular formula: C21H26N2S2. Mole weight: 370.57. | |
| Thioridazine hydrochloride | Thioridazine hydrochloride is a dopamine receptor antagonist displaying antipsychotic activity. Thioridazine induces apoptosis via targeting the PI 3-K/Akt/mTOR/p70 S6K pathway, and induces G1 cell cycle arrest. Thioridazine exhibits anticancer activity in cervical, endometrial and breast cancer cells. Synonyms: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride; Thioridazine HCl; Sonapax hydrochloride; Thioridazine chloride; Mellaril hydrochloride; 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, hydrochloride (1:1); 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride; Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-, hydrochloride; Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-, monohydrochloride; 10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride; 2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine hydrochloride; Aldazine; Mallorol; Melleretten; Melleril; Melleril (tablet); Novoridazine; NSC 186060; Orsanil; Ridazin; Stalleril; Thioril; Thiozine. Grades: ≥99% by HPLC. CAS No. 130-61-0. Molecular formula: C21H26N2S2.HCl. Mole weight: 407.04. | |
| Thiosophorose | Thiosophorose, distinguished as a notable compound, holds immense recognition in the realm of biomedicine due to its profound potential as an efficacious antiviral agent. Its application in inhibiting the proliferation and replication of specific viruses, including Influenza A and HIV, has proven remarkably encouraging. Moreover, Thiosophorose exhibits invaluable prospects in the continuum of targeted therapeutic measures against viral infections, thereby presenting novel avenues for treatment in the dynamic domain of the biomedical industry. Synonyms: 2-S-b-D-Glucopyranosyl-2-thiol-D-glucopyranose. CAS No. 92051-25-7. Molecular formula: C12H22O10S. Mole weight: 358.4. | |
| Thiothixene | Thiothixene is a thioxanthene derivative and a dopamine antagonist with antipsychotic property. It is used in the treatment of psychoses like schizophrenia. It blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thus decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects. It blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. It possesses weak affinity for the histamine H1 and alpha-adrenergic receptors. It was introduced on July 24, 1967 by Pfizer. It has been listed. Uses: Thiothixene is used in the treatment of psychoses like schizophrenia. Synonyms: CP 12,252-1; NSC 108165; P 4657B; cis-Thiothixene; NSC-108165; CP-12,252-1; Thiothixene; Tiotixene; Navane; Tiotixeno; Tiotixenum; (9Z) -N, N-Dimethyl-9-[3- (4-methyl-1-piperazinyl) propylidene]-9H-thioxanthene-2-sulfonamide; 2- (Dimethylsulfamoyl) - (9- (4-methyl-1-piperazinyl) propylidene) thioxanthene; 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (Z). Grades: 98%. CAS No. 5591-45-7. Molecular formula: C23H29N3O2S2. Mole weight: 443.62. | |
| Threo-2-Pentulose(9CI) | Threo-2-Pentulose (9CI), a common pentose sugar utilized as a reference standard for synthesizing other compounds in the biomedical industry, has no direct therapeutic applications. Nonetheless, its chemical properties have deemed it crucial in the development of drugs and treatments associated with diseases like cancer and diabetes. Furthermore, Threo-2-Pentulose (9CI) can be applied as a chiral resolution reagent and is integral in preparing diverse biochemicals. CAS No. 5962-29-8. | |
| Thymidine-5-diphosphate-D-glucose disodium salt | Thymidine-5-diphosphate-D-glucose disodium salt, an indispensable compound extensively employed in the biomedical sector, assumes a vital position. Acting as a precursor for glycosylated nucleoside synthesis, it assumes significance in the investigation and management of diverse afflictions notably viral infections, cancer, and metabolic disorders. Synonyms: 2-Deoxy-thymidine-5-diphospho-a-D-glucose disodium salt; TDP-Glucose disodium salt. CAS No. 2196-62-5. Molecular formula: C16H24N2O16P2Na2. Mole weight: 608.29. | |
| Thymol-b-D-glucopyranoside | Thymol-b-D-glucopyranoside is a biomedical compound utilized in the treatment of various ailments. Derived from thyme, it possesses antioxidant and antimicrobial properties, making it effective against infections caused by bacteria and fungi. Synonyms: Thymol-beta-D-glucoside; THYMOL-BETA-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, 5-methyl-2-(1-methylethyl)phenyl; THYMOL-B-D-GLUCOPYRANOSIDE; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(5-methyl-2-propan-2-ylphenoxy)oxane-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-isopropyl-5-methylphenoxy)tetrahydro-2H-pyran-3,4,5-triol; 1-O-Thymyl-beta-D-glucopyranoside; Glucopyranoside, 1-O-thymyl-, beta-D-; Thymolglucoside; CHEBI:182146; AKOS027327245; NCGC00380175-01; 2-isopropyl-5-methylphenol-O-beta-d-glucopyranoside; W-201820. CAS No. 20772-23-0. Molecular formula: C16H24O6. Mole weight: 312.36. | |
| Tiazofurin | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. Uses: Antineoplastic agents. Synonyms: 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; CI 909; NSC 286-193. Grades: 97%. CAS No. 60084-10-8. Molecular formula: C9H12N2O5S. Mole weight: 260.27. | |
| Tiazotic acid | Tiazotic acid is used as an antioxidant. Uses: Tiazotic acid is used as an antioxidant. Synonyms: [(3-methyl-1H-1,2,4-triazol-5-yl)thio]acetic acid; [(5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetic acid; NSC 78999. Grades: 98%. CAS No. 64679-65-8. Molecular formula: C5H7N3O2S. Mole weight: 173.19. | |
| Tideglusib | Tideglusib is a potent, selective and irreversible small-molecule non-ATP-competitive GSK3 inhibitor. It has been investigated as a potential treatment for Alzheimer's disease and paralysis supranuclear palsy in Phase IIa and IIb clinical trials. Synonyms: 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione. Grades: >98%. CAS No. 865854-05-3. Molecular formula: C19H14N2O2S. Mole weight: 334.39. | |
| Tie2 kinase inhibitor | Tie2 kinase inhibitor is an optimized compound of SB-203580, selective to Tie2 with IC50 of 0.25 μM, 200-fold more potent than p38. Synonyms: Tie2-IN-5; Tie2 IN 5; Tie2IN5; Tie2 inhibitor 5; Tie2-inhibitor-5; Tie2 kinase inhibitor 5; Compound 5. Grades: >98%. CAS No. 948557-43-5. Molecular formula: C26H21N3O2S. Mole weight: 439.53. | |
| Tienilic Acid | Tienilic acid is a heterocyclic derivative of phenoxyacetic acid that acts as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. It is a good mechanism based inhibitor of CYP2C9, and is commonly used as diuretic, uricosuric, antihypertensive. Synonyms: Ticrynafen; Thienylic acid; Selacryn; Diflurex; 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid. Grades: 99%. CAS No. 40180-04-9. Molecular formula: C13H8Cl2O4S. Mole weight: 331.17. | |
| Tigapotide | PCK3145 is a synthetic 15-mer peptide corresponding to amino acids 31-45 of the 94-amino acid isoform of human prostate secretory protein (PSP-94) with potential anti-metastasis and anti-angiogenesis activities. PSP-94-derived peptide PCK3145 may inhibit the secretion of the metastasis-related protein matrix metalloproteinase-9 (MMP-9) and its potential binding to its cell surface receptor CD44; may interfere with the vascular endothelial growth factor (VEGF) signaling pathway, resulting in an anti-angiogenesis effect; and may reduce the levels of parathyroid hormone-related protein (PTHrP), decreasing plasma calcium levels. PSP-94, one of three predominant proteins found in seminal fluid, may be down-regulated in prostate cancer, representing a potential survival mechanism for prostate cancer cells. MMP-9 is implicated in the invasion and metastasis of cancer. PTHrP may be expressed by various tumor cell types, resulting in the hypercalcemia of malignancy. Synonyms: PCK3145. Chemical name: L-Threonine, L-glutamyl-L-tryptophyl-L-glutaminyl-L-threonyl-L--aspartyl-L-asparaginyl-S-[(acetylamino)methyl]-L-cysteinyl-L-glutamyl-L-threonyl-S-[(acetylamino)methyl]-L-cysteinyl-L-threonyl-S-[(acetylamino)methyl]-L-cysteinyl-L-t. CAS No. 848084-83-3. Molecular formula: C82H119N21O34S3. Mole weight: 2039.15. | |
| Tilvestamab | Tilvestamab is a humanized anti-AXL function blocking monoclonal antibody. Tilvestamab inhibited AXL activation induced by Gas6 stimulation in vitro. Tilvestamab inhibited the progression of tumors induced by the orthotopically implanted 786-0 renal cell carcinoma cells. Synonyms: BGB149; BGB 149; BGB-149. CAS No. 2226775-26-2. | |
| Timcodar dimesilate | Timcodar, also known as VX-853, is a Novel Multidrug Resistance Inhibitor. Timcodar was under clinical trials to treat cancaners and other diseases. Timcodar potentiated the activity of ethidium bromide (EtBr), a model efflux substrate, against three clinically significant gram-positive pathogens: Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. Similar to reserpine, VX-853 directly blocked EtBr efflux in S. aureus. Furthermore, VX-853 was effective in lowering the MICs of several clinically used antibiotics, including fluoroquinolones, suggesting that VX-853 are representatives of a new class of bacterial efflux inhibitors with the potential for use in combination therapy. Synonyms: VX-853; VX 853; VX853. CAS No. 183313-30-6. Molecular formula: C45H53ClN4O12S2. Mole weight: 941.51. | |
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