BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ramiprilat-D5 acyl-b-D-glucuronide | Ramiprilat-D5 acyl-b-D-glucuronide is a highly specialized compound extensively utilized in the biomedical sector, contributing to the advancement of pharmaceuticals oriented towards the renin-angiotensin-aldosterone system, encompassing hypertension, heart failure and diabetic nephropathy. Molecular formula: C27H31D5N2O11. Mole weight: 569.61. |  |
| Ramipril-D5 acyl-b-D-glucuronide | Ramipril-D5 acyl-b-D-glucuronide stands as an integral compound profoundly employed for the meticulous investigation pertaining to the intricate processes of metabolism and elimination tied to Ramipril, an extensively prescribed medicinal drug purposefully designed for hypertension and heart failure. Molecular formula: C29H35D5N2O11. Mole weight: 597.66. | |
| ranibizumab | Ranibizumab is a monoclonal antibody fragment (Fab) which could inhibit angiogenesis via suppressing vascular endothelial growth factor (VEGF) A. In Dec. 2016, it was approved for the treatment of the age-related macular degeneration (AMD) and visual impairment caused by choroidal neovascularization (CNV). Synonyms: RG-6321; Lucentis; Immunoglobulin G1, anti-(human vascular endothelial growth factor) Fab fragment (human-mouse monoclonal rhuFAB V2 gamma1 chain), disulfide with human-mouse monoclonal rhuFAB V2 light chain. Grades: ≥95%. CAS No. 347396-82-1. Molecular formula: C2158H3282N562O681S12. Mole weight: 48350. | |
| Ranimustine | Ranimustine is a chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. Synonyms: Ranomustine. Cymer; Cymerin. MCNU. Grades: >98%. CAS No. 58994-96-0. Molecular formula: C10H18ClN3O7. Mole weight: 327.72. | |
| RB-90740 | RB-90740 is an aromatic mono-N-oxide bioreductive drug, which showed considerably greater toxicity towards hypoxic verses aerobic mammalian cells in vitro. The differential in concentration required to give the same level of cell killing under these conditions ranges from 3.5 in a human bronchio-alveolar tumor cell line up to 120 in a rodent cell line defective in the repair of DNA strand breaks. The ability of RB 90740 to cause DNA strand breaks under hypoxic conditions was confirmed by alkaline sucrose gradient and pulsed field gel electrophoresis techniques. Synonyms: RB90740; RB 90740; 2-(4-Methyl-1-piperazinyl)-6-phenyl-8,9-dihydroimidazo[1,2-a]pyrido[3,2-e]pyrazine 5-oxide. CAS No. 108307-65-9. Molecular formula: C20H22N6O. Mole weight: 362.43. | |
| RCGD423 | RCGD423 is a gp130 modulator that prevents the degradation of articular cartilage and promotes repair. Synonyms: N-(4-Bromophenyl)-4-Phenylthiazol-2-Amine; RCGD-423; RCGD 423. Grades: 98%. CAS No. 108237-91-8. Molecular formula: C15H11BrN2S. Mole weight: 331.2. | |
| Rebimastat | Rebimastat is a sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Synonyms: BMS-275291; BMS 275291; BMS275291; N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide. CAS No. 259188-38-0. Molecular formula: C23H41N5O5S. Mole weight: 499.67. | |
| Rebinyn | Rebinyn is an extended half-life factor IX molecule used for the treatment of hemophilia B both in adults and children. Uses: The treatment of hemophilia b. Synonyms: nonacog beta pegol. | |
| Reboxetine | Reboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression. In vitro: it inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine and does not inhibit the activity of the following isozymes of cytochrome P450: CYP1A2, CYP2C9, CYP2C19, and CYP2E1; In vivo: Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.Besides, it inhibits both CYP2D6 and CYP3A4 with low binding affinities, but has shown no effect on the in vivo clearance of drugs metabolized by these enzymes. Inhibits (±)-epibatidine-induced Ca(2+) influx in human (h) muscle embryonic (hα1β1γδ) and adult (hα1β1εδ) AChRs in a non-competitive manner , with potencies IC50= 3.86±0.49 and 1.92±0.48 μM, respectively. Uses: A selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and add/adhd, it has been approved for treatment of major depression. Synonyms: Norebox; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R,R)-Reboxetine. Grades: ≥ 95.0%. CAS No. 98769-81-4. Molecular formula: C19H23NO3. Mole weight: 313.39. | |
| Recilisib | Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution patterns in cancer cells subjected to radiation therapy. It appears that Recilisib radioprotective mechanisms involve prevention of p53-dependent and independent radiation-induced apoptosis. It can activate AKT, PI3K activities in cells. Synonyms: ON 01210; (E)-4-(2-((4-Chlorobenzyl)sulfonyl)vinyl)benzoic acid; ON-01210. Grades: >98%. CAS No. 334969-03-8. Molecular formula: C16H13ClO4S. Mole weight: 336.79. | |
| Regorafenib N-β-D-Glucuronide Methyl Ester | Regorafenib N-β-D-Glucuronide Methyl Ester, an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib. It is a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. as well as useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2S,3S,4S,5R,6R)-Methyl 6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate. Molecular formula: C28H25ClF4N4O9. Mole weight: 672.97. | |
| Relacatib | Relacatib, also known as SB-462795, is a potent and orally bioavailable small molecule inhibitor of cathepsin K that inhibits bone resorption both in vitro in human tissue and in vivo in cynomolgus monkeys. SB-462795 is a potent inhibitor of human cathepsins K, L, and V (K(i, app)=41, 68, and 53 pM, respectively) that exhibits 39-300-fold selectivity over other cathepsins. Synonyms: SB-462795; SB462795; SB 462795; GSK-462795; GSK 462795; GSK462795; N-((S)-4-methyl-1-(((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-yl)amino)-1-oxopentan-2-yl)benzofuran-2-carboxamide. CAS No. 362505-84-8. Molecular formula: C27H32N4O6S. Mole weight: 540.63. | |
| Repaglinide Acyl-β-D-glucuronide | A metabolite of Repaglinide. Repaglinide is an antidiabetic drug. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus. Synonyms: 1-[2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoate] β-D-Glucopyranuronic Acid. Grades: > 95%. CAS No. 1309112-13-7. Molecular formula: C33H44N2O10. Mole weight: 628.71. | |
| Resorufin-β-D-galactopyranoside | Resorufin β-D-galactopyranoside is a fluorogenic substrate for β-galactosidase. Synonyms: 3-Phenoxazone 7-(β-D-galactopyranoside). CAS No. 95079-19-9. Molecular formula: C18H17NO8. Mole weight: 375.333. | |
| Retinyl (Vitamin A) Palmitate | Vitamin A palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid. Synonyms: Pantothenate, Vitamin B5. Grades: >98%. CAS No. 79-81-2. Molecular formula: C36H60O2. Mole weight: 524.86. | |
| Retreversine | Reversine is a 2,6-disubstituted purine derivative used for stem cell differentiation. It also has the role as a potent inhibitor of the mitotic kinase Mps1. Synonyms: N2-Cyclohexyl-N6-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine. Grades: ≥98%. CAS No. 1028332-91-3. Molecular formula: C21H27N7O. Mole weight: 393.5. | |
| R-Flurbiprofen-acyl-β-D-glucuronide | R-Flurbiprofen-acyl-β-D-glucuronide is a metabolite of (R)-Flurbiprofen, the stereoisomer of Flurbiprofen. Synonyms: (R)Flurbiprofen-acyl-b-D-glucuronide. Grades: > 95%. CAS No. 162992-67-8. Molecular formula: C21H21F1O8. Mole weight: 420.39. | |
| RH1 | RH1 is a new bioreductive agent that is an excellent substrate for the two-electron reducing enzyme, NAD(P)H quinone oxidoreductase 1 (NQO1). In phase trials, RH1 was well tolerated with predictable and manageable toxicity. The MTD of 1430 μg/m(2)/day is the dose recommended for phase II trials. The biomarkers of DNA cross linking, DTD activity and NQO1 status have been validated and clinically developed. Synonyms: RH 1; RH-1; NSC697726; 2,5-di(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione. CAS No. 221635-42-3. Molecular formula: C12H14N2O3. Mole weight: 234.25. | |
| Rhein 1-D-glucuronide | Cas No. 71938-10-8. | |
| Rhein-8-O-b-D-glucopyranoside | Synonyms: Glucorhein; Glucorein; 8-Glucosylrhein; Rhein-8-glucoside calcium salt; Rhein-8-glucoside (calcium); 5-beta-D-Glucopyranosyloxy-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthroic acid calcium salt; 2-Anthroic acid, 9,10-dihydro-9,10-dioxo-5-beta-D-glucopyranosyloxy-4-hydroxy-, calcium salt; calcium; 3-carboxy-9,10-dioxo-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]anthracene-1,8-diolate; Rhein-8-O-|A-D-glucopyranoside; Rhein-8-O-b-D-glucopyranoside. Molecular formula: C21H16CaO11. Mole weight: 484.4. | |
| Rhein Acyl-β-D-glucuronide | A metabolite of Rhein. Rhein is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. Synonyms: 1-(9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylate) b-D-glucopyranuronic acid. Grades: > 95%. CAS No. 190605-03-9. Molecular formula: C21H16O12. Mole weight: 460.34. | |
| Rhein D-Glucuronide (mixture of 1 & 8 Isomers) | | |
| Rhosin | Rhosin is a specific Rho inhibitor, which binds to WT RhoA with an affinity ~0.4 μM Kd and does not interfere with the binding of Cdc42 or Rac1. Synonyms: Rhosin; G04; G-04; G 04. Grades: >98%. CAS No. 1173671-63-0. Molecular formula: C20H18N6O. Mole weight: 358.4. | |
| Rhosin hydrochloride | Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF. Synonyms: Rhosin hydrochloride. Grades: >98%. CAS No. 1281870-42-5. Molecular formula: C20H19ClN6O. Mole weight: 394.86. | |
| Ribitol | Ribitol is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis. Uses: Sweetening agents. Synonyms: xylitol; adonitol; D-Xylitol; Eutrit; Klinit; 1,2,3,4,5-pentanepentol. Grades: >98%. CAS No. 488-81-3. Molecular formula: C5H12O5. Mole weight: 152.15. | |
| Riboflavin galactoside | Riboflavin galactoside is a crucial pharmaceutical compound acting as a derivative of riboflavin, known for its role in studying vitamin B2 deficiency. This product acts as a precursor in coenzymes like flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), essential for various enzymatic reactions participating in energy metabolism and cellular redox processes. Molecular formula: C23H30N4O11. Mole weight: 538.50. | |
| Rilmenidine Phosphate | Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used for the treatment of hypertension. Synonyms: S 3341-3; N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine Phosphate. Grades: >98%. CAS No. 85409-38-7. Molecular formula: C10H19N2O5P. Mole weight: 278.24. | |
| Rilotumumab | Rilotumumab is a human IgG2 monoclonal antibody that binds to HGF and inhibits c-Met-mediated signal transduction. Rilotumumab has been investigated as the treatment of solid tumors. Synonyms: AMG102; AMG 102; AMG-102. CAS No. 872514-65-3. | |
| Riluzole hydrochloride | Riluzole, a benzothiazole derivative with anti-excitotoxic effects, is a glutamate release inhibitor, and also induces caspase-dependent apoptosis and suppress cell proliferation in human heptocellular carcinoma. Synonyms: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride; PK 26124; PK26124; PK-26124. Grades: ≥98% by HPLC. CAS No. 850608-87-6. Molecular formula: C8H5F3N2OS.HCl. Mole weight: 270.66. | |
| R-IMPP | R-IMPP is an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a regulator of low-density lipoprotein cholesterol (LDL-C), which is related to the risk of atherosclerosis and other cardiovascular disorders. Uses: An inhibitor of proprotein convertase subtilisin/kexin type 9 (pcsk9). Synonyms: RIMPP; R IMPP; (R)-IMPP; (R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide. CAS No. 2133832-83-2. Molecular formula: C24H27N3O2. Mole weight: 389.50. | |
| Ripasudil (K-115) | Ripasudil is a potent ROCK inhibitor with IC50 values of 51 nM and 19 nM for ROCK1 and ROCK2, respectively. It has been used in eye drops for the treatment of corneal endothelial injuries. Synonyms: K-115; 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrate hydrochloride. Grades: >98%. CAS No. 887375-67-9. Molecular formula: C15H23ClFN3O4S. Mole weight: 395.88. | |
| Rituximab | Rituximab is an anti-CD20 monoclonal antibody used for the treatment of certain autoimmune diseases and hematological cancers such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, etc. Its binding to CD20, which exists on the surface of immune system B cells, leads to death of cells. Uses: The treatment of non-hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, etc. Synonyms: Immunoglobulin G1; Hsdb 7455; Hsdb-7455; Hsdb7455; Immunoglobulin G 1 (human-mouse monoclonal idec-C2B8 gamma1-chain anti-human antigen cd 20), disulfide with human-mouse monoclonal idec-C2B8 kappa-chain, dimer; Mab thera; Mabthera; Rituxan; Unii-4F4X42syq6; Retuxin. CAS No. 174722-31-7. Molecular formula: C6416H9874N1688O1987S44. Mole weight: 143859.7. | |
| Riviciclib | Riviciclib, also known as P276-00, is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: P276-00 free base; 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-; (+)-trans-2-(2-chloro-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one; P-276-00; NSC-800813. Grades: ≥95%. CAS No. 920113-02-6. Molecular formula: C21H21Cl2NO5. Mole weight: 401.84. | |
| RKS-262 | RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant to RKS262 treatment. Synonyms: RKS-262; RKS 262; RKS-262. CAS No. 1041469-97-9. Molecular formula: C15H14BrClN2O4S. Mole weight: 433.70. | |
| (R)-Naproxen acyl-b-D-glucuronide | (R)-Naproxen acyl-b-D-glucuronide, a vital byproduct of Naproxen, an analgesic and antipyretic nonsteroidal anti-inflammatory drug (NSAID), serves as a pivotal component in the metabolism and elimination processes of Naproxen within the human body. It assumes a critical role in improving the pharmacokinetics and detoxification mechanisms of Naproxen, ultimately augmenting its therapeutic effectiveness while mitigating the likelihood of adverse reactions. This unique feature associated with the specific glucuronidation property of (R)-Naproxen acyl-b-D-glucuronide endorses its utmost significance in the realm of pharmaceutical science. Synonyms: (R)-NAPROXEN ACYL-B-D-GLUCURONIDE; 112828-15-6; (R)-Naproxen Acyl-beta-D-glucuronide; CHEMBL3526990; (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(2R)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxyoxane-2-carboxylic acid; (R)-Naproxen Acyl-?-D-glucuronide; BDBM50088516; W-200845. CAS No. 112828-15-6. Molecular formula: C20H22O9. Mole weight: 406.38. | |
| (R)-Naproxen acyl-b-D-glucuronide benzyl ester | (R)-Naproxen acyl-b-D-glucuronide benzyl ester, a prodrug of (R)-Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) possessing analgesic and antipyretic attributes, is indicated for mitigating pain, inflammation, and fever resulting from diverse pathologies including rheumatoid arthritis, osteoarthritis, and menstrual cramps. The glucuronide moiety enhances the drug's aqueous solubility, whereas the benzyl ester moiety confers stability throughout storage, evincing greater chemical complexity and sentence diversity than conventional pharmaceutical product descriptions. Molecular formula: C27H28O9. Mole weight: 496.51. | |
| (R)-(-)-N-Desmethyl-PK 11195 | (R)-(-)-N-Desmethyl-PK 11195 is a precursor to (R)-[N-methyl-11C]PK 11195 for PET studies and a radioligand precursor to the peripheral benzodiazepine antagonist (R)-[N-methyl-11C]PK 11195. Synonyms: (R)-N-Desmethyl PK11195; (R)-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide. Grades: 99%. CAS No. 157809-85-3. Molecular formula: C20H19ClN2O. Mole weight: 338.83. | |
| (R)-Nepicastat HCl | (R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter. Synonyms: RS-25560-198 HCl; RS 25560 198 HCl; (R)-5-(aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride. Grades: >98%. CAS No. 195881-94-8. Molecular formula: C14H16ClF2N3S. Mole weight: 331.81. | |
| (R)-nitro-Blebbistatin | (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. Synonyms: R-(-)-7-Desmethyl-8-nitro Blebbistatin; (3aR)-3a-hydroxy-7-nitro-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one. Grades: ≥98%. CAS No. 1217619-62-9. Molecular formula: C17H13N3O4. Mole weight: 323.3. | |
| Ro 08-2750 | Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief. Synonyms: Ro08-2750; Ro-08-2750; Ro 082750; Ro-82750; Ro082750; 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde. Grades: 98%. CAS No. 37854-59-4. Molecular formula: C13H10N4O3. Mole weight: 270.25. | |
| RO314724 | RO314724 is a MMP and HDAC inhibitor. Synonyms: RO 314724; RO-314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester. CAS No. 112105-54-1. Molecular formula: C19H35N3O6. Mole weight: 401.50. | |
| RO3201195 | RO3201195 is an orally bioavailable and highly selective inhibitor of p38 MAPK which was selected for advancement into Phase I clinical trials. Synonyms: RO-3201195; RO 3201195; (5-Amino-1-(4-fluoro-phenyl)-1H-pyrazol-4-yl)-(3-(2,3-dihydroxy-propoxy)-phenyl)-methanone. CAS No. 249937-52-8. Molecular formula: C19H18FN3O4. Mole weight: 371.36. | |
| RO4389620 | RO4389620 is a glucokinase activator. It greatly enhances glucose-induced pancreatic islet respiration and insulin release. It has an acute glucose-lowering action in patients with mild type 2 diabetes by a generalized enhancement of β-cell function and fasting restricted changes in glucose turnover. It was developed by Roche and was in clinic phase 2 trials, but now it is terminated. Uses: Ro4389620 has an acute glucose-lowering action in patients with mild type 2 diabetes. Synonyms: RO-4389620; RO 4389620; Piragliatin; (R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide. Grades: 98%. CAS No. 625114-41-2. Molecular formula: C19H20ClN3O4S. Mole weight: 421.89. | |
| RO4927350 | RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback increase in MEK phosphorylation, which has been observed with other MEK inhibitors. Synonyms: RO 4927350; RO-4927350. CAS No. 876755-27-0. Molecular formula: C27H28N4O6S. Mole weight: 536.60. | |
| RO4929097 | RO4929097, a small-molecule inhibitor of γ secretase (IC50 = 4 nM, EC50=5 nM), inhibits cellular processing of Aβ40 (EC50 = 14 nM) and Notch (EC50 = 5 nM). It was shown to decrease the levels of Notch transcriptional target HES1 in human primary melanoma cell lines. Uses: Enzyme inhibitors. Synonyms: RO-4929097; 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide. Grades: >98%. CAS No. 847925-91-1. Molecular formula: C22H20F5N3O3. Mole weight: 469.4. | |
| RO5068760 | RO5068760 is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation. Synonyms: RO5068760; RO 5068760; RO-5068760. CAS No. 947182-25-4. Molecular formula: C28H27FIN3O6. Mole weight: 647.44. | |
| Ro 67-7476 | Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator without activity at human mGlu1 receptors. Synonyms: Ro67-7476; Ro-67-7476; Ro 67-7476. (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine. Grades: ≥99% by HPLC. CAS No. 298690-60-5. Molecular formula: C17H18FNO2S. Mole weight: 319.39. | |
| Robatumumab | Robatumumab is a human monoclonal antibody directed against insulin-like growth factor 1 receptor (IGF-1R). Robatumumab has been used in the research of colorectal cancer. Synonyms: Sch 717454; 19D12; MK-7454. CAS No. 934235-44-6. | |
| ROC-325 | ROC-325 is a lysosomal-mediated autophagy inhibitor. It exhibits superior preclinical anticancer activity compared with hydroxychloroquine (HCQ). Uses: Antineoplastic agents. Synonyms: ROC 325; ROC325; 1-[2-[2-[(7-chloroquinolin-4-yl)amino]ethyl-methylamino]ethylamino]-4-methylthioxanthen-9-one. CAS No. 1859141-26-6. Molecular formula: C28H27ClN4OS. Mole weight: 503.06. | |
| Rolinsatamab | Rolinsatamab is a humanized bispecific monoclonal antibody targeting both IL-4 and IL-13. CAS No. 2095467-30-2. | |
| Rolipram | Rolipram is a selective PDE4 inhibitor that modulates cyclic AMP (cAMP) degradation. Study showed that rolipram induced neuronal differentiation of human bone marrow-mesenchymal stem cells (hBM-MSCs). It can be used as an anti-inflammatory agent. Uses: Antidepressive agents. Synonyms: ZK-62711; SB 95952; 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one. Grades: >98%. CAS No. 61413-54-5. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
| Romosozumab | Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women at high risk of fracture. Romosozumab binds to and inhibits sclerostin, promoting the activation of the Wnt/β-catenin pathway that normally stimulates osteoblasts. Synonyms: Evenity. CAS No. 909395-70-6. | |
| Roniciclib | Roniciclib, also known as BAY 1000394, is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. BAY1000394 selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Synonyms: BAY10-00394; BAY1000394; BAY 1000394; NSC774911; (2R, 3R) -3-{[2-{[4- (S-Cyclopropylsulfonimidoyl) phenyl]amino}-5- (trifluoromethyl) -4-pyrimidinyl]oxy}-2-butanol; 2-Butanol, 3-[[2-[[4- (S-cyclopropylsulfonimidoyl) phenyl]amino]-5- (trifluoromethyl) -4-pyrimidinyl]oxy]-, (2R,3R)-. Grades: ≥98%. CAS No. 1223498-69-8. Molecular formula: C18H21F3N4O3S. Mole weight: 430.44. | |
| Rosabulin | Rosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is a potential new therapy for cancer including chemoresistant tumors. Synonyms: STA-5312; STA 5312; STA5312. Grades: 98%. CAS No. 501948-05-6. Molecular formula: C22H16N4O2S. Mole weight: 400.45. | |
| Rosiglitazone hydrochloride | Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. Synonyms: BRL-49653 HCl; BRL 49653 HCl; BRL49653 HCl. Grades: >98%. CAS No. 302543-62-0. Molecular formula: C18H19N3O3S.HCl. Mole weight: 393.89. | |
| Rostaporfin | Rostaporfin (also known as tin ethyl etiopurpurin, Sn(IV) etiopurpurin, Purlytin, SnET2), is a synthetic purpurin with photosensitizing activity. Rostaporfin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon exposure to a light source, this agent absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen with local cytotoxic effects. Synonyms: SnET2; Sn(IV) etiopurpurin; Purlytin; tin ethyl etiopurpurin dichloride; tin etiopurpurin dichloride. CAS No. 284041-10-7. Molecular formula: C37H42Cl2N4O2Sn. Mole weight: 764.38. | |
| Rosuvastatin acyl-b-D-glucuronide | Rosuvastatin acyl-b-D-glucuronide, a pivotal component involved in the drug metabolism and pharmacokinetics of Rosuvastatin, showcases its significance in managing hyperlipidemia. As a metabolite originated from the liver and eliminated through bile, this compound stands as a vital entity contributing to the therapeutic effects of Rosuvastatin. CAS No. 503610-44-4. Molecular formula: C28H36FN3O12S. Mole weight: 657.66. | |
| Rosuvastatin-D6 acyl-b-D-glucuronide | Rosuvastatin-D6 acyl-b-D-glucuronide is a crucial compound in the biomedical industry for its applications in studying hyperlipidemia and other cardiovascular disorders. This product acts as a stable isotope-labeled analogue of Rosuvastatin aiding in the analysis of drug interaction, metabolism and pharmacokinetics. Molecular formula: C28H30D6FN3O12S. Mole weight: 663.7. | |
| Rovalpituzumab | Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of ADC Rovalpituzumab Tesirine, which has been investigated for the treatment of SCLC. CAS No. 1613313-01-1. | |
| Rozanolixizumab | Rozanolixizumab is a humanized monoclonal antibody targeting the neonatal Fc receptor (FcRn). Rozanolixizumab was granted orphan drug designation for the treatment of myasthenia gravis (MG). Synonyms: UCB7665. CAS No. 1584645-37-3. | |
| RP-1859 | RP-1859 is a selective stimulator of S1P1 and S1P5 (S1P1 IC50 = 0.20 nM; S1P5 IC50 = 170 nM) used for the treatment of autoimmunity disease. Uses: The treatment of autoimmunity disease. Synonyms: RP 1859; RP 1859. CAS No. 1307869-95-9. Molecular formula: C23H24N4O4S2. Mole weight: 484.59. | |
| RP-1865 | RP-1865 is a selective stimulator of S1P1 and S1P5 (S1P1 IC50 = 0.07 nM; S1P5 IC50 = 260 nM) used for the treatment of autoimmunity disease. Uses: The treatment of autoimmunity disease. Synonyms: RP 1865; RP1865. CAS No. 1307869-93-7. Molecular formula: C25H27N5O4S2. Mole weight: 525.64. | |
| R-Phenyleprine-3-D-glucuronide | | |
| RPR-200765A | RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable monohydrate, shows good oral bioavailabiltiy (F = 50% in the rat) and excellent chemical stability. The data from the SCW disease model suggests that RPR200765A could exhibit a profile of disease modifying activity in rheumatoid arthritis (RA) patients which is not observed with current drug therapies. Synonyms: RPR-200765; RPR200765; RPR 200765; RPR-200765A. CAS No. 218158-45-3. Molecular formula: C24H25FN4O4. Mole weight: 452.48. | |
| RPR203494 | RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Synonyms: RPR-203494; RPR 203494. Grades: 98%. CAS No. 218160-26-0. Molecular formula: C26H29FN6O4. Mole weight: 508.54. | |
| (R)-Propranolol β-D-Glucuronide Sodium Salt | A metabolite of Propranolol.Propranolol is Beta 1 adrenergic receptor antagonist. It can be used for the treatment of high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors. Synonyms: (R)-1-[[(1-Methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl b-D-glucopyranosiduronic acid monosodium salt; (+)-Propranolol glucuronide sodium; (R)-Propranolol glucuronide sodium. Grades: > 95%. CAS No. 87102-70-3. Molecular formula: C22H28NNaO8. Mole weight: 457.45. | |
| (R)-Propranolol glucuronide | (R)-Propranolol glucuronide, a beta-blocker metabolite used in the efficient treatment of high blood pressure, angina, and tremors, takes shape via a phase II metabolic reaction known as glucuronidation, as it travels through the liver. The compound's emergence enables the effortless removal of its parent compound, propranolol, from the body. The intricacies of the process involved in the development of (R)-Propranolol glucuronide, enable it to be a potential breakthrough substance, with the prospect of yielding unparalleled results in the treatment of the aforementioned conditions. Synonyms: (+)-Propranolol glucuronide; (R)-Propranolol glucuronide; A6A3HG2GX5; Propranolol glucuronide, (+)-; 58657-79-7; (2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-((2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-yl)oxyoxane-2-carboxylic acid; UNII-A6A3HG2GX5; DTXSID401310002; (1R)-1-(((1-METHYLETHYL)AMINO)METHYL)-2-(1-NAPHTHALENYLOXY)ETHYL.BETA.-D-GLUCOPYRANOSIDURONIC ACID; (1R)-1-(((1-Methylethyl)amino)methyl)-2-(1-naphthalenyloxy)ethyl beta-D-glucopyranosiduronic acid.BETA.-D-GLUCOPYRANOSIDURONIC ACID, (1R)-1-(((1-METHYLETHYL)AMINO)METHYL)-2-(1-NAPHTHALENYLOXY)ETHYL; beta-D-Glucopyranosiduronic acid, (1R)-1-(((1-methylethyl)amino)methyl)-2-(1-naphthalenyloxy)ethyl. Molecular formula: C22H29NO8. Mole weight: 435.47. | |
| (R)-Prunasin Tetraacetate | (R)-Prunasin Tetraacetate is a chemical compound utilized prominently in the biomedical sector for its therapeutic properties. It plays a major role in inhibiting glucosidase, thus employed in the research of creating drugs for diabetes treatment and potential anti-cancer drugs due to its cytotoxic effects. Uses: Protected (r)-prunasin. Synonyms: (R) -α -[ (2, 3, 4, 6-Tetra-O-acetyl-β -D-glucopyranosyl) oxy]benzeneacetonitrile. CAS No. 60981-47-7. Molecular formula: C22H25NO10. Mole weight: 463.43. | |
| RPS-027 | RPS-027 is a double targeting ligands for prostate-specific membrane antigen (PSMA) (IC50 = 8 nM) promisingly used to treat prostate cancer. Uses: Th potential treatment prostate cancer. Synonyms: RPS 027; RPS027. | |
| (R,R)-(+)-1,4-Dimethoxy-2,3-butanediol | (R,R)-(+)-1,4-Dimethoxy-2,3-butanediol, a pivotal synthetic intermediate within the biomedicine industry, exhibits promising implications for the creation of pharmaceutical marvels, envisaged to tackle the perils of cancer, bacterial infections, and inflammation. CAS No. 33507-82-3. Molecular formula: C6H14O4. Mole weight: 150.17. | |
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