BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| RS-102221 | RS-102221 is a drug developed by Hoffmann-La Roche, which was one of the first compounds discovered that acts as a potent and selective antagonist at the serotonin 5-HT2C receptor, with around 100x selectivity over the closely related 5-HT2A and 5-HT2B receptors. It has anxiolytic effects in animal studies, increases the effectiveness of SSRI antidepressants, and shows a complex interaction with cocaine, increasing some effects but decreasing others, reflecting a role for the 5-HT2C receptor in regulation of the dopamine signalling system in the brain. Synonyms: RS 102221; RS102221; N-{5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl]-2,4-dimethoxyphenyl}-4-trifluoromethylbenzenesulfonamide. Grades: 98%. CAS No. 185376-97-0. Molecular formula: C27H31F3N4O7S. Mole weight: 612.62. |  |
| (RS)-3,4-DCPG | (RS)-3,4-DCPG is a systemically active anticonvulsant. Uses: Anticonvulsant agent. Synonyms: (RS)-3,4-Dicarboxyphenylglycine; SR-01000597399; SR 01000597399; SR01000597399. Grades: ≥99% by HPLC. CAS No. 176796-64-8. Molecular formula: C10H9NO6. Mole weight: 239.18. | |
| R,S-Ambrisentan-acyl-b-D-glucuronide | R,S-Ambrisentan-acyl-b-D-glucuronide is a pharmaceutical compound utilized in the research of pulmonary arterial hypertension (PAH). It acts as a metabolite of Ambrisentan that is a selective endothelin receptor antagonist. CAS No. 1106685-82-8. Molecular formula: C28H30N2O10. Mole weight: 554.55. | |
| R,S-Equol 7-b-D-glucuronide sodium salt | R,S-Equol 7-b-D-glucuronide sodium salt is a sodium salt derivative of R,S-Equol is a soy isoflavone daidzein metabolite. It finds utility within the biomedical sector, primarily focusing on the research of hormone-dependent ailments including breast and prostate cancer. Synonyms: 3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-yl-b-D-glucuronide. CAS No. 38482-82-5. Molecular formula: C21H21NaO9. Mole weight: 440.38. | |
| (R)-Talarozole | Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases including psoriasis and acne. Synonyms: N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine R 115866 R-115866 R115866 Rambazole talarozole. CAS No. 870093-23-5. Molecular formula: C21H23N5S. Mole weight: 377.51. | |
| Rurioctocog alfa pegol | Rurioctocog alfa pegol is an extended circulating half-life recombinant Factor VIII (rFVIII) treatment for hemophilia A in patients under 12 years old. Uses: The treatment for hemophilia a in patients under 12 years old. Synonyms: Adynovate; BAX-855. CAS No. 1417412-83-9. Molecular formula: C21H40N4O10. Mole weight: 508.57. | |
| RWJ-67657 | RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells. Synonyms: RWJ 67657; RWJ67657; 3-Butyn-1-ol, 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-. Grades: 98%. CAS No. 215303-72-3. Molecular formula: C27H24FN3O. Mole weight: 425.51. | |
| (S)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde | (S)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (CAS# 22323-80-4 ) is a useful research chemical. Synonyms: (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde; (4S)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde. CAS No. 22323-80-4. Molecular formula: C6H10O3. Mole weight: 130.14. | |
| S31-201 | S31-201 is benezoic acid based small molecule, which inhibits the Stat3 transcription factor by blocking the phosphorylation and dimerization events necessary for activation. Many cancers express aberrant behavior in the Stat3 growth factor, making this compound a valuable tool for perturbing the chemistry of such systems. Synonyms: NSC 74859; NSC74859; NSC-74859; S3I-201; S3I 20; S3I201. Grades: >98%. CAS No. 501919-59-1. Molecular formula: C16H15NO7S. Mole weight: 365.36. | |
| (S)-3-((2R,3S,5S)-5-Allyl-3-(benzyloxy)-4-oxotetrahydrofuran-2-yl)propane-1,2-diyl dibenzoate | (S)-3-((2R,3S,5S)-5-Allyl-3-(benzyloxy)-4-oxotetrahydrofuran-2-yl)propane-1,2-diyl dibenzoate, a chemical compound demonstrating properties for anti-cancer drug development, exhibits pronounced inhibition of cancer cells through modulation of the cell cycle and promotion of apoptosis. Current research explores its potential for treating conditions pertaining to inflammation and oxidative stress. CAS No. 871348-04-8. | |
| S-3304 | S-3304 is an orally-agent agent with potential antineoplastic activity. S-3304 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Synonyms: S 3304; S3304. CAS No. 193809-34-6. Molecular formula: C24H20N2O4S2. Mole weight: 464.55. | |
| (S)-3-((3aR,5R,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propane-1,2-diol | (S)-3-((3aR,5R,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propane-1,2-diol is an indispensable constituent in the biomedical sector, owing to its pivotal role as a significant precursor in the preparation of a host of pharmacologically active compounds. Its versatile and unique structure makes it an ideal synthetic building block for natural product derivatives, thereby opening up new avenues for the treatment and management of a broad spectrum of maladies such as cancer, viral infections, and neurological disorders. The interplay of its functional groups makes it a potent therapeutic agent with immense potential for the alleviation of human suffering. CAS No. 871347-98-7. | |
| (S)-3'-amino Blebbistatin | (S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. Synonyms: (-)-3'-amino Blebbistatin; m-amino Blebbistatin; meta-amino Blebbistatin; (3aS)-1-(3-aminophenyl)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one. Grades: ≥95%. CAS No. 2097141-18-7. Molecular formula: C18H17N3O2. Mole weight: 307.35. | |
| (S)-3'-hydroxy Blebbistatin | (S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. Synonyms: (-)-3'-hydroxy Blebbistatin; meta-hydroxy-Blebbistatin; m-hydroxy-Blebbistatin; 1,2,3,3aS-tetrahydro-3a-hydroxy-1-(3-hydroxyphenyl)-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one. Grades: ≥95%. CAS No. 2097136-42-8. Molecular formula: C18H16N2O3. Mole weight: 308.33. | |
| S4 | S4 is a high affinity and selective carbonic anhydrase CA IX and CA XII inhibitor (Ki = 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). S4 has been shown to inhibit migration and proliferation of breast cancer cells in in vitro assays. S4 inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor. Synonyms: 4-[[[ (3, 5-Dimethylphenyl) amino]carbonyl]amino]phenyl sulfamate; CAIX Inhibitor S4. Grades: ≥99% by HPLC. CAS No. 1330061-67-0. Molecular formula: C15H17N3O4S. Mole weight: 335.38. | |
| (S)-4'-nitro-Blebbistatin | (S)-4'-nitro-Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. Synonyms: (-)-4'-nitro-Blebbistatin; p-nitro-Blebbistatin; para-nitro-Blebbistatin; (3aS)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-4H-pyrrolo[2,3-b]quinolin-4-one. Grades: ≥95%. CAS No. 1621326-32-6. Molecular formula: C18H15N3O4. Mole weight: 337.33. | |
| (S)-(-)-5-Hydroxymethyl-2(5H)-furanone | (S)-(-)-5-Hydroxymethyl-2(5H)-furanone, a vital compound extensively utilized in the biomedicine sector, possesses remarkable medicinal attributes. It is widely employed in the formulation of pharmaceuticals targeting diverse ailments. This compound exhibits substantial potential in combating cancer, neurodegenerative disorders, and cardiovascular diseases. Synonyms: (S)-(-)-Hydroxymethyl-3(2H)-furanone; (5S)-5-(hydroxymethyl)furan-2(5H)-one; (S)-5-Hydroxymethyl-2(5H)-furanone; (5S)-5-(Hydroxymethyl)-2(5H)-furanone. Grades: 95%. CAS No. 78508-96-0. Molecular formula: C5H6O3. Mole weight: 114.10. | |
| (S)-(-)-5-Iodowillardiine | (S)-(-)-5-Iodowillardiine is a potent agonist highly selective for GluK1-containing subtype kainate receptors with EC50 value of 0.21 μM. It does not interact with GluK2, GluK6, and GluK7 receptors, and has low affinity for AMPA receptors. It also has high affinity for the kainate receptor subtype hGluR5 and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6. It has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in apoptosis, necrosis and neuropathic pains. Synonyms: (S)-5-Iodowillardiine; (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid; (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid; Iodowillardiine. Grades: ≥98% by HPLC. CAS No. 140187-25-3. Molecular formula: C7H8IN3O4. Mole weight: 325.06. | |
| Sabarubicin hydrochloride | Sabarubicin is a disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin. Synonyms: BMS-195615; BMS 195615; BMS195615; MEN-10755; MEN 10755; MEN10755. CAS No. 169317-77-5. Molecular formula: C32H38ClNO13. Mole weight: 680.10. | |
| Sabatolimab | Sabatolimab is a humanized monoclonal antibody directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Sabatolimab has been approved for the treatment of adult patients with myelodysplastic syndromes (MDS). Synonyms: MBG453; NVP-MBG453. CAS No. 2252262-24-9. | |
| Sabutoclax | Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Synonyms: BI-97C1; BI 97C1; BI97C1; (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide; (R)-1,1'',6,6'',7,7''-Hexahydroxy-3,3''-dimethyl-N5-((R)-2-phenylpropyl)-N5''-((R)-2-phenylpropyl)-2,2''-binaphthyl-5,5''-dicarboxamide; NSC-787780. Grades: >98%. CAS No. 1228108-65-3. Molecular formula: C42H40N2O8. Mole weight: 700.78. | |
| Saccharin 1-methylimidazole | Saccharin 1-methylimidazole is an activator for DNA and RNA synthesis. Synonyms: SMI; 1,1-dioxo-1,2-benzothiazol-3-one;1-methylimidazole. CAS No. 482333-74-4. Molecular formula: C7H5NO3S·C4H6N2. Mole weight: 265.29. | |
| Sacituzumab | Sacituzumab is a humanized monoclonal antibody directed against Trop-2. Sacituzumab has been used in the research of metastatic triple-negative breast cancer. CAS No. 1796566-95-4. | |
| SAG | SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor. Synonyms: SAG. Grades: 98%. CAS No. 912545-86-9. Molecular formula: C28H28ClN3OS. Mole weight: 490.06. | |
| Sagopilone | Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum. Synonyms: DE 03757; DE-03757; DE03757; ZK 219477; ZK219477; ZK-219477; ZK-EPO; (1S,3S,7S,10R,11S,12S,16R)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methylbenzo[d]thiazol-5-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione. CAS No. 305841-29-6. Molecular formula: C30H41NO6S. Mole weight: 543.72. | |
| Salacinol | Salacinol is a naturally occurring compound derived from Salacia species. It aids in studying type 2 diabetes by inhibiting α-glucosidase and decreasing glucose absorption in the intestine. Synonyms: 1,4-Dideoxy-1,4-[(S)-[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]episulfoniumylidene]-D-arabinitol inner salt; (1S,2R,3S,4S)-1-[(2S,3S)-2,4-Dihydroxy-3-(sulfooxy)butyl]tetrahydro-3,4-dihydroxy-2-(hydroxymethyl)thiophenium inner salt. CAS No. 200399-47-9. Molecular formula: C9H18O9S2. Mole weight: 334.37. | |
| Salicylanilide | Salicylanilide has a wide range of biological activities, including antiviral, anti-inflammatory, antibacterial and so on. It inhibits HIV virus by targeting HIV-1 integrase or reverse transcriptase. It inhibits mycobacterial isocitrate lyase (ICL) and has a significant antimycobacterial effect. It can be used as an antiseptic. Synonyms: 2-Hydroxybenzanilide; 2-(N-Phenylcarboxamido)phenol; 2-(Phenylaminocarbonyl)phenol; Ansadol; Aseptolan; Hyanilid; N-Phenyl-2-hydroxybenzamide; N-Phenylsalicylamide; NSC 14881; Salicylanilid; Salicylic acid anilide; Salifebrin; Salinide; Salinidol; Salnide; Shirlan; o-Hydroxybenzanilide. Grades: ≥95%. CAS No. 87-17-2. Molecular formula: C13H11NO2. Mole weight: 213.23. | |
| Salicylic acid-acyl-b-D-glucuronide | Salicylic acid-acyl-b-D-glucuronide, a metabolite of Salicylic acid, is widely used in skincare with anti-inflammatory and keratolytic properties. Its effectiveness in managing skin conditions such as acne and psoriasis, largely stems from its ability to regulate inflammation, promote exfoliation and the renewal of skin cells. From a biomedical perspective, Salicylic acid-acyl-b-D-glucuronide is an important agent used in pharmacokinetic research, specifically focused on understanding the metabolic pathways of Salicylic acid within the body. CAS No. 29315-53-5. Molecular formula: C13H14O9. Mole weight: 314.24. | |
| Salicylic acid ethyl ester b-D-glucuronide | Salicylic acid ethyl ester b-D-glucuronide is a compound widely used in research of various inflammatory skin conditions and acne. Its unique formulation allows for enhanced delivery of salicylic acid, an active ingredient known for its anti-inflammatory and keratolytic effects. Molecular formula: C15H18O9. Mole weight: 342.30. | |
| SANT-1 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. Synonyms: SANT-1; SANT 1; SANT1. Grades: >98%. CAS No. 304909-07-7. Molecular formula: C23H27N5. Mole weight: 373.49. | |
| Saprisartan | Saprisartan, a losartan structural derivative, has been found to be a AT1 receptor antagonist that was once studied its activity against hypertension. It has already been discontinued by GlaxoSmithKline. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: GR-138950; GR 138950; GR138950; 1-({3-bromo-2-[2-(trifluoromethane)sulfonamidophenyl]-1-benzofuran-5-yl}methyl)-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide. Grades: 98%. CAS No. 146623-69-0. Molecular formula: C25H22BrF3N4O4S. Mole weight: 611.43. | |
| SAR125844 | SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis. Synonyms: SAR 125844; SAR-125844; 1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea; Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-. Grades: >98%. CAS No. 1116743-46-4. Molecular formula: C25H23FN8O2S2. Mole weight: 550.63. | |
| SAR131675 (Racemate) | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nmol/L, respectively. Synonyms: (Rac)-SAR131675; 2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (±)-. Grades: ≥95%. CAS No. 1092539-44-0. Molecular formula: C18H22N4O4. Mole weight: 358.40. | |
| SAR260301 | SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. SAR260301 is being investigated for the treatment of PTEN-deficient tumors. SAR260301 displayed improved physicochemical and in vitro pharmacokinetic properties. SAR260301 demonstrated significant in vivo activity in a UACC-62 xenograft model in mice, warranting further preclinical investigation. Synonyms: SAR-260301; SAR 260301. Grades: >98%. CAS No. 1260612-13-2. Molecular formula: C19H22N4O3. Mole weight: 354.41. | |
| SAR-489883 | SAR-489883 is a potent and selective inhibitor of protein kinase R (PKR), which is potentially used to treat Alzheimer's disease. SAR-489883 reduced cognitive impairment in a mouse study, induced rescue of deficits in synaptic proteins (PSD-95, SNAP-25 and synaptophysin) as well as reduction of levels of interleukin-1 beta in ex vivo analyses. Uses: The potential treatment of alzheimer's disease. Synonyms: SAR489883; SAR 489883. | |
| Sardomozide | Sardomozide, also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. The in vivo phosphorylation of p53 at residues Ser(46)/Ser(392) and Mdm2 at residue Ser(166) was observed. SAM486A may be effective alternative agents for the treatment of NBs with or without MYCN amplification. Uses: Antineoplastic agents. Synonyms: CGP 48664; CGP-48664; CGP48664; SAM 486A; SAM-486A; SAM486A. Grades: >98%. CAS No. 149400-88-4. Molecular formula: C11H14N6. Mole weight: 230.27. | |
| Sardomozide HCl | Sardomozide , also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). Synonyms: Sardomozide 2HCl; Sardomozide dihydrochloride; 2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride. Grades: 98%. CAS No. 138794-73-7. Molecular formula: C11H16Cl2N6. Mole weight: 303.19. | |
| Saridegib | Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity, one of smoothened (Smo) inhibitors. Synonyms: SARIDEGIB; IPI-926 Hydrochloride; Patidegib. CAS No. 1037210-93-7. Molecular formula: C29H48N2O3S. Mole weight: 504.77. | |
| sarilumab | Cas No. 1189541-98-7. | |
| Satralizumab | Satralizumab is a humanized monoclonal antibody that inhibits interleukin-6 (IL-6) receptor. Satralizumab has been developed for the treatment of neuromyelitis optica spectrum disorder (NMOSD). Synonyms: Enspryng. CAS No. 1535963-91-7. | |
| SB202190 | SB202190, also named FHPI, under the IUPAC name 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one, is a pyridinyl imidazole that selectively inhibits the p38α and β isoforms. IC50=50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively. Uses: A highly selective, potent and cell-permeable inhibitor of p38 map kinase(ic50 = 50 and 100 nm at sapk2a/p38 and sapk2b/p38β2) respectively). Synonyms: 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; SB 202190; SB-202190; SB202190; SB 202190; 152121-30-7; SB-202190; SB202190; FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; SB 202190, Immobilized; InSolution SB 202190; IN1110; IN1113; MFCD00941964; 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole; 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; C20H14FN3O; SB202190 (FHPI); SB202190, 152121-30-7; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-i.. Grades: >98%. CAS No. 152121-30-7. Molecular formula: C20H14FN3O. Mole weight: 331.34. | |
| SB 203580 hydrochloride | SB 203580 hydrochloride is a water-soluble form of the potent MAP kinase inhibitor SB 203580 with IC50 values of 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. It was shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole hydrochloride. Grades: >98%. CAS No. 869185-85-3. Molecular formula: C21H17FN3OSCl. Mole weight: 413.9. | |
| SB 204990 | SB 204990 is a prodrug of SB 201076, which is an ATP citrate lyase (ACLY) inhibitor. SB 204990 inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. SB 204990 was shown to decrease plasma levels of the lipoproteins VLDL, LDL, and HDL in dogs. Synonyms: SB-204990; SB 204990; SB204990; (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid. Grades: ≥98% by HPLC. CAS No. 154566-12-8. Molecular formula: C18H22Cl2O5. Mole weight: 389.27. | |
| SB-216763 | SB216763 is a glycogen synthase kinase-3 (GSK3) inhibitor. It can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). Synonyms: SB-216763; 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: >98%. CAS No. 280744-09-4. Molecular formula: C19H12Cl2N2O2. Mole weight: 371.217. | |
| SB-218078 | SB-218078 is a potent and selective indolocarbazole chk1 inhibitor. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. Synonyms: SB218078; SB 218078; SB-218078. Grades: ≥98%. CAS No. 135897-06-2. Molecular formula: C24H15N3O3. Mole weight: 393.40. | |
| SB 268262 | SB 268262 is a selective and non-peptide calcitonin gene-related peptide (CGRP1) receptor antagonist. SB 268262 inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 = 0.24 and 0.83 nM, respectively). Synonyms: SB 268262; SB-268262; SB268262; N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide. Grades: ≥99% by HPLC. CAS No. 217438-17-0. Molecular formula: C18H15N3O4S2. Mole weight: 401.46. | |
| SB271046 | SB-271046 is found to be a competitive antagonist with a pA2 of 8.7 in the functional adenylyl cyclase assay which is in good agreement with its binding affinity. Synonyms: SB 271046; SB-271046; 5-Chloro-N-(4-methoxy-3-(1-piperazinyl)phenyl)-3-methylbenzo(b)thiophene-2-sulfonamide. Grades: >98%. CAS No. 209481-20-9. Molecular formula: C20H22ClN3O3S2. Mole weight: 451.99. | |
| SB273005 | SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM.SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. Synonyms: SB 273005; SB-273005; (S)-2-(8-(2-(6-(Methylamino)pyridin-2-yl)ethoxy)-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl)acetic acid. Grades: >98%. CAS No. 205678-31-5. Molecular formula: C22H24F3N3O4. Mole weight: 451.44. | |
| SB415286 | SB415286 is a potent GSK3α inhibitor with IC50 and Ki values of 78 nM and 31 nM,respectively. Synonyms: SB-415286; SB 415286; SB415286. Grades: >98%. CAS No. 264218-23-7. Molecular formula: C16H10ClN3O5. Mole weight: 359.72. | |
| SB505124 | SB505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF-β and activin but does not inhibit other ALK family members. Synonyms: SB-505124; 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine. Grades: >98%. CAS No. 694433-59-5. Molecular formula: C20H21N3O2. Mole weight: 335.407. | |
| SB756050 | SB756050 is a selective TGR5 agonist currently undergone testing in a phase 1 clinical trials study in the treatment of type 2 diabetes. Synonyms: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane; SB756050; F1018-1711; 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane; SB-756050; SB 756050; SB756050. CAS No. 447410-57-3. Molecular formula: C21H28N2O8S2. Mole weight: 500.59. | |
| Sbc-1107326 | SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9). Study shows that it can lower cholesterol levels in mice. Synonyms: Sbc 1107326; Sbc1107326; N-[4-(2-Phenyl-4-p-tolyl-piperazine-1-carbonyl)-phenyl]-acetamide. Grades: ≥98%. CAS No. 1629166-02-4. Molecular formula: C26H27N3O2. Mole weight: 413.51. | |
| SBI0206965 | SBI-0206965 is a novel selective inhibitor of the autophagy-initiating kinase ULK1 (IC50 = 108 nM) that is less effective against ULK2 (IC50 = 711 nM). SBI0206965 promoted apoptosis in NSCLC cells independent of autophagy, which was partly mediated by destabilization of Bcl2/Bclxl. Synonyms: 2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide; SBI-0206965; SBI 0206965; NSC-784816; Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-; 2-({5-Bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}oxy)-N-methylbenzamide. Grades: 98%. CAS No. 1884220-36-3. Molecular formula: C21H21BrN4O5. Mole weight: 489.33. | |
| SBI-477 | SBI-477 is a small-molecule probe that can stimulate insulin signaling by deactivating the transcription factor MondoA, causing reduction of expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). It coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes in study. Uses: Probe. Synonyms: SBI 477; SBI477. CAS No. 781628-99-7. Molecular formula: C24H25N3O6S. Mole weight: 483.54. | |
| SC-144 hydrochloride | SC-144 hydrochloride is the first-in-class orally active small-molecule glycoprotein 130 (gp130) inhibitor. It inhibits cell growth in a panel of human ovarian cancer cell lines with IC50 values in a submicromolar range. It shows greater potency in human ovarian cancer cell lines than in normal epithelial cells. It binds gp130, induces gp130 phosphorylation and deglycosylation, thus abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. It inhibits the growth of several tumor cell lines and inhibits growth of ovarain tumor xenografts in mice. It shows potent inhibition of gp130 ligand-triggered signaling. Uses: Sc-144 hydrochloride inhibits the growth of several tumor cell lines and inhibits growth of ovarain tumor xenografts. Synonyms: SC-144 hydrochloride; SC 144 hydrochloride; SC144 hydrochloride; 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide-2-pyrazinecarboxylic acid hydrochloride;SC144 hydrochloride;SC-114 HCl;N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;hydrochloride. Grades: >98%. CAS No. 917497-70-2. Molecular formula: C16H12ClFN6O. Mole weight: 358.76. | |
| SC-236 | SC-236 is a potent, selective COX-2 inhibitor. Uses: Cyclooxygenase inhibitors. Synonyms: SC-236; SC 236; SC236; 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide. CAS No. 170569-86-5. Molecular formula: C16H11ClF3N3O2S. Mole weight: 401.8. | |
| SC-44463 | SC-44463 is an MMP inhibitor, also a collagenase inhibitor , and HDAC inhibitor. Synonyms: SC44463; SC 44463; (R)-N4-hydroxy-2-isobutyl-N1-((S)-3-(4-methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl)succinamide. CAS No. 104408-38-0. Molecular formula: C19H29N3O5. Mole weight: 379.45. | |
| SC-51089 | The hydrochloride salt form of SC-51089, a benzoxazepine derivative, has been found to be a EP1 prostanoid receptor antagonist and could probably influence the growth of tumors in vivo and have neuroprotective acticity. Synonyms: SC 51089; SC51089; 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride. Grades: 98%. CAS No. 146033-02-5. Molecular formula: C22H20Cl2N4O3. Mole weight: 459.33. | |
| SC-58125 | SC-58125 is a selective COX-2 inhibitor. Uses: Cyclooxygenase inhibitors. Synonyms: SC-58125; SC 58125; SC58125; 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole. CAS No. 162054-19-5. Molecular formula: C17H12F4N2O2S. Mole weight: 384.3. | |
| SC58451 | SC58451 is a potent and selective Cox-2 (IC50= 1.1 nM) and was found to be orally active (EDs0 = 0.3 mpk) in the rat adjuvant-induced arthritis model with no gastric lesions observed at 200 mpk. Synonyms: SC58451; SC 58451; SC-58451; 5-(4-fluorophenyl)-6-(4-methylsulfonylphenyl)spiro[2.4]hept-5-ene. CAS No. 168433-84-9. Molecular formula: C20H19FO2S. Mole weight: 342.43. | |
| SC75741 | SC75741 is a potent NF-κB inhibitor (EC50=200 nM). Synonyms: SC75741; SC 75741; SC-75741. Grades: >98%. CAS No. 913822-46-5. Molecular formula: C29H23N7O2S2. Mole weight: 565.67. | |
| SCH 529074 | SCH 529074 is a small molecule activator of mutant p53 that binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. SCH 529074 blocks ubiquitination of p53 by HDM2, and induces apoptosis in tumor cell lines. Synonyms: SCH 529074; SCH529074; SCH-529074; N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine. Grades: ≥98% by HPLC. CAS No. 922150-11-6. Molecular formula: C31H36Cl2N6. Mole weight: 563.56. | |
| Scopolamine β-D-Glucuronide | A metabolite of scopolamine. Scopolamine is an acetylcholine antagonist used in treatment of motion sickness, postoperative nausea and vomiting, antispasmodic, mydriatic, preanesthetic medicant. Synonyms: (2S)-3-[[(1α, 2β, 4β, 5α, 7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02, 4]non-7-yl]oxy]-3-oxo-2-phenylpropyl β-D-Glucopyranosiduronic Acid; (-)-Scopolamine 9'-glucuronide; Scopolamine O-β-D-glucuronide. Grades: > 95%. CAS No. 17660-02-5. Molecular formula: C23H29NO10. Mole weight: 479.48. | |
| SCR7 | SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. Synonyms: SCR7; SCR 7; SCR-7. Grades: >98%. CAS No. 1533426-72-0. Molecular formula: C18H14N4OS. Mole weight: 334.39. | |
| (S)-crizotinib | (S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells. Synonyms: S-Crizotinib; ent-crizotinib. Grades: >98%. CAS No. 1374356-45-2. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.34. | |
| scyllo-Inosamine | scyllo-Inosamine is an intricately designed synthetic compound widely employed in studying grievous neurodegenerative afflictions such as Alzheimer's and Parkinson's disease. Its exalted status arises from its possession of remarkable neuroprotective attributes and its finesse in modifying enzyme activity. Synonyms: 1-Amino-1-deoxy-scyllo-inositol. CAS No. 16051-25-5. Molecular formula: C6H13NO5. Mole weight: 179.17. | |
| scyllo-Inosamine hydrochloride | scyllo-Inosamine hydrochloride is a multifaceted biomedical constituent evolved from inositol, having prospects in studying neurodegenerative ailments like Alzheimer's and Parkinson's. Synonyms: 1-Amino-1-deoxy-scyllo-inositol HCl. CAS No. 4933-84-0. Molecular formula: C6H13NO4 HCl. Mole weight: 199.63. | |
| scyllo-Inositol | scyllo-Inositol is a renowned chemical compound, serving as a cornerstone in studying an array of neurological ailments, such as the dreaded Alzheimer's disease and the debilitating Parkinson's disease. Acknowledged for its antioxidative properties, this compound assists in studying the build-up of pernicious proteins within the cerebral domain. Synonyms: inositol; myo-inositol; Scyllo-inositol; epi-Inositol; Muco-Inositol; Allo-inositol; i-Inositol;alloinositol; neoinositol; Hexahydroxycyclohexane; scyllo-Cyclohexanehexol; 1D-myo-Inositol; 1L-myo-Inositol; Inositol, cis-; Inositol, epi-; Inositol, neo-; epi-Cyclohexanehexol; (+)-Inositol; 1,2,3,4,5,6-Cyclohexanehexol; (-)-chiro-Inositol; ELND005; Rat antispectacled eye factor; Levoinositol1111. CAS No. 488-59-5. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| Scytonemin | Scytonemin is a biological pigment synthesized by many strains of cyanobacteria. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin (at 3 and 4 μM concentration) inhibited multiple myeloma cell growth associated with downregulation of the activity of Plk1 but no effect on the expression of Plk1. Scytonemin, representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity. Taken together, scytonemin is a promising novel agent for the treatment of multiple myeloma. Synonyms: (3E,3'E)-3,3'-bis(4-hydroxybenzylidene)-[1,1'-bi(cyclopenta[b]indole)]-2,2'(3H,3'H)-dione; (1,1'-Bicyclopent(b)indole)-2,2'(3H,3'H)-dione, 3,3'-bis((4hydroxyphenyl)methylene)-3,3'-Bis((4-hydroxyphenyl)methylene)-(1,1'-bicyclopent(b)indole)-2,2'(3H,3'H)-dione. Grades: 98%. CAS No. 152075-98-4. Molecular formula: C36H20N2O4. Mole weight: 544.56. | |
| SD-282 | SD-282 is an ATP-competitive inhibitor of p38 kinase. SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. SD-282 may have potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes. Synonyms: SD282; SD 282; SCIO-282; SCIO 282; SCIO282; rac-Talmapimod. CAS No. 309915-13-7. Molecular formula: C27H30ClFN4O3. Mole weight: 513.00. | |
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