BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| K-252c | K252c, a metabolite product of Nocardiopsis Sp., has been found to be a protein kinase C inhibitor and exhibit antiviral activities against GCV-sensitive and-resistant strains at some extent. Uses: K252c inhibits protein kinase c. its reported ic50 value of 214 nm on rat brain enzyme k252c is cytotoxic for a549 and p388 cancer celllines showing ic50 = 2-3 μm. Synonyms: Staurosporine aglycone; K252C; 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one. Grade: ≥97%. CAS No. 85753-43-1. Molecular formula: C20H13N3O. Mole weight: 311.34. |  |
| K 259-2 | K-259-2, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was isolated from the cultured broth of Micromonospora olivasterospora K-259. IC50 values for the effect of K-259-2 against Ca2+ and calmodulin-stimulated activity of the enzyme preparations from bovine brain and heart were 6.6 and 2.9 microM, respectively. Synonyms: K-259-2; 1,6,8-Trihydroxy-3-[(Z)-2-ethyl-2-butenyl]-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid. CAS No. 102819-46-5. Molecular formula: C21H18O7. Mole weight: 382.36. | |
| K 41 | K 41 is originally isolated from Streptomyces hygroscopicus K-41 with anti-gram-positive bacteria activity. Synonyms: (29S)-9,13:17,20:21,24-trianhydro-4,8,10,12,14,18,19,22,23,26,28,30-dodecadeoxy-4,12,14,26,28-pentamethyl-6,16-di-C-methyl-5,6,11,15-tetra-O-methyl-27-O-[(2R,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]-L-xylo-L-manno-α-D-gluco-L-ribo-α-L-gluco-D-glycero-3,13,29-triacontotriulo-13,16-furanose-3,7:29,25-dipyranosonic acid. CAS No. 53026-37-2. Molecular formula: C48H82O18. Mole weight: 947.15. | |
| KA 7038IV | KA 7038IV is originally isolated from Streptomyces sp. KA-7038 with anti-Gram-positive bacteria and weak anti-Gram-negative bacteria activity. Synonyms: Antibiotic KA 7038IV; BRN 1387553; 2-Amino-3,6-dihydroxy-4-methoxy-5-(methylamino)cyclohexyl 2,6-diamino-2,3,4,6-tetradeoxyhexopyranoside. CAS No. 73491-60-8. Molecular formula: C14H30N4O5. Mole weight: 334.41. | |
| Kaempferol tetramethyl ether | Kaempferol tetramethyl ether, a natural product found in Bryobium eriaeoides and Meistera koenigii, is a PPARγ agonist that can improve insulin sensitivity by increasing the levels of adiponectin. Synonyms: Tetramethylkaempferol; 4H-1-Benzopyran-4-one, 3,5,7-trimethoxy-2-(4-methoxyphenyl)-; 3,5,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; Flavone, 3,4',5,7-tetramethoxy-; 2-(4-Methoxyphenyl)-3,5,7-trimethoxy-4-oxo-4H-1-benzopyran; 3,4',5,7-Tetramethoxyflavone; 3,5,7,4'-Tetra-O-methylkaempferol; 3,5,7,4'-Tetramethoxyflavone; 3,5,7-Trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; O-Tetramethylkaempferol. Grade: ≥95%. CAS No. 16692-52-7. Molecular formula: C19H18O6. Mole weight: 342.34. | |
| Kalafungin | Kalafungin is a quinone antibiotic produced by the strain of Str. tanashiensis Kala (NRRL 3215). It has anti-gram-positive bacterial and fungal effects as well as anti-parasite activity. Synonyms: Kalamycin; NSC137443; Antibiotic U-19,718; 3,3a,5,11b-Tetrahydro-7-hydroxy-5-methyl-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione. Grade: ≥95%. CAS No. 11048-15-0. Molecular formula: C16H12O6. Mole weight: 300.26. | |
| Kalimantacin A | Kalimantacin A is originally isolated from Alcaligenes sp. YL-02632S. It has anti-Gram-positive bacteria (including multi-drug resistant bacteria) and some gram-negative bacteria activities. CAS No. 174513-95-2. Molecular formula: C30H48N2O7. Mole weight: 548.71. | |
| Kanchanamycin C | Kanchanamycin C is originally isolated from Str. olivaceus TU4018. It has anti-gram positive and negative bacteria, yeast and filamentous fungus action. Molecular formula: C54H91N3O17. Mole weight: 1054.31. | |
| Kanglemycin A | Kanglemycin A (KglA) is related to rifampicin, an antibiotic that functions by binding to bacterial RNA polymerase. KglA binds bacterial RNA polymerase at the rifampicin-binding pocket but maintains potency against RNA polymerases containing rifampicin-resistant mutations. KglA has antibiotic activity against rifampicin-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis. Synonyms: Antibiotic 1747; Rifamycin, 20-(1-(3-carboxy-2,2-dimethyl-1-oxopropoxy)ethyl)-20-demethyl-27-O-demethyl-1,4-dideoxy-27-O-(2,6-dideoxy-3,4-O-methylene-beta-D-ribo-hexopyranosyl)-1,4-dihydro-1,4-dioxo-; Kanglemeisu A; KglA. CAS No. 114153-91-2. Molecular formula: C50H63NO19. Mole weight: 982.03. | |
| Kapurimycin A1 | It is originally isolated from Str. sp. DO-15. Kapurimycin A1 can resist gram-positive bacteria and a few gram-negative bacteria. Synonyms: [8-(Acetyloxy)-12-hydroxy-2-(2-methyl-3-propyloxiran-2-yl)-4,11-dioxo-8,9,10,11-tetrahydro-4H-anthra[1,2-b]pyran-5-yl]acetic acid. CAS No. 132412-65-8. Molecular formula: C27H26O9. Mole weight: 494.49. | |
| Kapurimycin A2 | It is originally isolated from Str. sp. DO-15. Kapurimycin A2 can resist gram-positive bacteria and a few gram-negative bacteria. Synonyms: 8-Acetyloxy-2-(3-ethyl-2-methyloxiran-2-yl)-8,9,10,11-tetrahydro-12-hydroxy-4,11-dioxo-4H-anthra[1,2-b]pyran-5-acetic acid; [8-(Acetyloxy)-2-(3-ethyl-2-methyloxiran-2-yl)-12-hydroxy-4,11-dioxo-8,9,10,11-tetrahydro-4H-anthra[1,2-b]pyran-5-yl]acetic acid. Grade: ≥98%. CAS No. 132412-64-7. Molecular formula: C26H24O9. Mole weight: 480.46. | |
| Kapurimycin A3 | It is originally isolated from Str. sp. DO-15. Kapurimycin A3 can resist gram-positive bacteria and a few gram-negative bacteria. Synonyms: 4H-Anthra(1,2-b)pyran-5-acetic acid, 8-(acetyloxy)-8,9,10,11-tetraahydro-12-hydroxy-2-(2-methyl-3-(1-propenyl)oxiranyl)-4,11-dioxo-. Grade: >98%. CAS No. 129966-45-6. Molecular formula: C27H24O9. Mole weight: 492.47. | |
| Karalicin | Karalicin is produced by the strain of Pseudomonus fluorescens/putida SS-3. It inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC50 (μg/mL) of 0.004, 0.008, 0.016 and 0.016. Synonyms: 3-O-Acetyl-1-deoxy-1-(4-methoxyphenyl)pentitol. Molecular formula: C14H20O6. Mole weight: 284.30. | |
| Katanosin A | Katanosin A is a peptide antibiotic originally isolated from Cytophaga sp. PBJ-5356. It has anti-gram-positive bacterial effect. Synonyms: L-Serine, N-[threo-3-hydroxy-N2-[N-[N-[N-[N2-[N-[threo-3-hydroxy-N-[threo-b-hydroxy-N-(N-D-leucyl-L-leucyl)-L-phenylalanyl]-L-leucyl]-L-leucyl]-D-arginyl]-L-valyl]-L-allothreonyl]glycyl]-L-asparaginyl]-,b1-lactone. CAS No. 116103-86-7. Molecular formula: C57H95N15O17. Mole weight: 1262.45. | |
| Kaur-16-ene-3,18-diol, (3α,4α)- | Kaur-16-ene-3,18-diol, (3α,4α)-. Synonyms: Kaur-16-ene-3α,18-diol (7CI); (3α,4α)-Kaur-16-ene-3,18-diol; 1H-2,10a-Ethanophenanthrene, kaur-16-ene-3,18-diol deriv; ent-3α-Hydroxykaur-16-en-18-ol. CAS No. 18524-59-9. Molecular formula: C20H32O2. Mole weight: 304.47. | |
| Kaur-16-ene, 3,18-epoxy-, (3α,4α)- | Kaur-16-ene, 3,18-epoxy-, (3α,4α)-. CAS No. 19891-43-1. Molecular formula: C20H30O. Mole weight: 286.45. | |
| Kaur-16-ene-3α,18-diol, cyclic phosphorochloridate | Kaur-16-ene-3α,18-diol, cyclic phosphorochloridate. Synonyms: Kaur-16-ene-3α,18-diol, cyclic phosphorochloridate (8CI). CAS No. 22488-83-1. Molecular formula: C20H30ClO3P. Mole weight: 384.88. | |
| Kauran-18-oic acid, 12α,17-dihydroxy-, methyl ester, (-)-, 16βH- | Kauran-18-oic acid, 12α,17-dihydroxy-, methyl ester, (-)-, 16βH-. Synonyms: 16βH-Kauran-18-oic acid, 12α,17-dihydroxy-, methyl ester, (-)- (8CI). CAS No. 20108-26-3. Molecular formula: C21H34O4. Mole weight: 350.49. | |
| Kauran-18-oic acid, 12β,17-dihydroxy-, methyl ester, diacetate, (-)-, 16βH- | Kauran-18-oic acid, 12β,17-dihydroxy-, methyl ester, diacetate, (-)-, 16βH-. Synonyms: 16βH-Kauran-18-oic acid, 12β,17-dihydroxy-, methyl ester, diacetate, (-)- (8CI). CAS No. 20108-23-0. Molecular formula: C25H38O6. Mole weight: 434.57. | |
| Kauran-18-oic acid, 16,17-dihydroxy-, methyl ester, (4α)- | Kauran-18-oic acid, 16,17-dihydroxy-, methyl ester, (4α)-. Synonyms: Methyl ent-16α,17-dihydroxy-kauran-19-oate; ent-16α,17-Dihydroxy-kauran-19-oic acid methyl ester. CAS No. 3557-81-1. Molecular formula: C21H34O4. Mole weight: 350.49. | |
| Kauran-18-oic acid, 17-hydroxy-, methyl ester, (4α,16α)- | Kauran-18-oic acid, 17-hydroxy-, methyl ester, (4α,16α)-. Synonyms: 16βH-Kauran-18-oic acid, 17-hydroxy-, methyl ester (7CI,8CI). CAS No. 3301-52-8. Molecular formula: C21H34O3. Mole weight: 334.49. | |
| Kaurane-3α,16,17,18-tetrol, cyclic 3,18:16,17-diacetal with acetone, (-)- | Kaurane-3α,16,17,18-tetrol, cyclic 3,18:16,17-diacetal with acetone, (-)-. Synonyms: Kaurane-3α,16,17,18-tetrol, cyclic 3,18:16,17-diacetal with acetone, (-)- (8CI). CAS No. 19891-45-3. Molecular formula: C26H42O4. Mole weight: 418.61. | |
| Kaurane-3α,16,17-triol, cyclic 16,17-acetal with acetone, acetate, (-)- | Kaurane-3α,16,17-triol, cyclic 16,17-acetal with acetone, acetate, (-)-. Synonyms: Kaurane-3α,16,17-triol, cyclic 16,17-acetal with acetone, acetate, (-)- (8CI). CAS No. 19891-32-8. Molecular formula: C25H40O4. Mole weight: 404.58. | |
| Kaurane-3α,18-diol, 16,17-epoxy-, diacetate, (-)- | Kaurane-3α,18-diol, 16,17-epoxy-, diacetate, (-)-. Synonyms: Kaurane-3α,18-diol, 16,17-epoxy-, diacetate, (-)- (8CI). CAS No. 19891-49-7. Molecular formula: C24H36O5. Mole weight: 404.54. | |
| Kendomycin | Kendomycin is an endothelin receptor antagonist and proteasome inhibitor. It induces apoptosis in lymphoma. It is a potent antibacterial agent against gram-positive and gram-negative bacteria, including MRSA strains. Synonyms: TAN 2162. Grade: >95% by HPLC. CAS No. 183202-73-5. Molecular formula: C29H42O6. Mole weight: 486.64. | |
| Kerriamycin A | Produced by the strain of Str. Violaceolatus, Kerriamycin A has anti-gram-positive bacterial effect and can also prolong the survival time of patients with Ai's ascites cancer. Synonyms: Benz(a)anthracene-1,7,12(2H)-trione, 9-(2,6-dideoxy-3-O-((2S-(2alpha,5beta,6beta))-5-((2,6-dideoxy-beta-L-erythro-hexopyranos-3-ulos-1-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-beta-D-arabino-hexopyranosyl)-3,4,4a,12b-tetrahydro-3,4a,8-trihydrox. CAS No. 98474-20-5. Molecular formula: C43H54O17. Mole weight: 842.88. | |
| Kerriamycin C | It is produced by the strain of Str. Violaceolatus. Kerriamycin C has anti-gram-positive bacterial effect and can also prolong the survival time of patients with Ai's ascites cancer. Synonyms: Antibiotic A 32Y3; Benz[a]anthracene-1,7,12(2H)-trione,9-[2,6-dideoxy-3-O-[[2S-(2a,5b,6b)]-5-[(2,6-dideoxy-b-D-arabino-hexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]-b-D-arabino-hexopyranosyl]-3,4,4a,12b-tetrahydro-3,4a,8,12b-tetrahydroxy-3-methyl-,[3R-(3a,4aa,12ba)]-. CAS No. 98495-38-6. Molecular formula: C37H46O15. Mole weight: 730.75. | |
| Kibdelin A | Kibdelin A is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin A is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Synonyms: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 103528-50-3. Molecular formula: C81H84Cl4N8O29. Mole weight: 1775.38. | |
| Kibdelin B | Kibdelin B is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin B is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Synonyms: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((9-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 103528-49-0. Molecular formula: C82H86Cl4N8O29. Mole weight: 1789.41. | |
| Kibdelin C1 | Kibdelin C1 is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin C1 is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Synonyms: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((10-methyl-1-oxoundecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 103549-47-9. Molecular formula: C83H88Cl4N8O29. Mole weight: 1803.43. | |
| Kibdelin C2 | Kibdelin C2 is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin C2 is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Synonyms: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((1-oxododecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 105997-85-1. Molecular formula: C83H88Cl4N8O29. Mole weight: 1803.43. | |
| Kibdelin D | Kibdelin D is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin D is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Synonyms: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((1-oxo-4-decenyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 105997-86-2. Molecular formula: C81H82Cl4N8O29. Mole weight: 1773.36. | |
| Kibdelone A | It is a potent antitumour metabolite isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. It's cytotoxic. Synonyms: (10S,12S,13R)-4-Chloro-10,11,12,13-tetrahydro-10,12,13,15-tetrahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,5,14,16-tetrone. Grade: >95% by HPLC. CAS No. 934464-77-4. Molecular formula: C29H24ClNO10. Mole weight: 581.96. | |
| Kibdelone B | It is a minor analogue of a potent antitumour complex isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. Synonyms: (10R,12R,13S)-rel-(+)-4-Chloro-6,7,10,11,12,13-hexahydro-10,12,13,15-tetrahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,5,14,16-tetrone. Grade: >95% by HPLC. CAS No. 934464-78-5. Molecular formula: C29H26ClNO10. Mole weight: 583.97. | |
| Kibdelone C | It is the major analogue of a potent antitumour complex isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. Synonyms: (10S,12S,13R)-4-Chloro-6,7,10,11,12,13-hexahydro-5,10,12,13,15,16-hexahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,14-dione; (+)-Kibdelone C. Grade: >95% by HPLC. CAS No. 934464-79-6. Molecular formula: C29H28ClNO10. Mole weight: 585.99. | |
| Kigamicin A | Kigamicin A is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C34H35NO13. Mole weight: 665.64. | |
| Kigamicin B | Kigamicin B is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C40H45NO15. Mole weight: 779.78. | |
| Kigamicin D | Kigamicin D is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. It also shows effect against L-1210 LB32T and other genera tumor cells with IC50 of 1 μg/mL. Synonyms: 1,2,3a,4,6,7,10,11,12,13-Decahydro-11-[[5-[[5-[(tetrahydro-5-hydroxy-4-methoxy-6-methyl-2H-pyran-2-yl)oxy]tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-10,13,15,16-tetrahydroxy-3a-methyl-7,8-(methylenedioxy)-17a-aza-3,9-dioxa-17aH-cyclopenta[b]hexaphene-14,17-dione. Molecular formula: C48H59NO19. Mole weight: 953.98. | |
| Kinamycin A | Kinamycin A is produced by the strain of Str. murayamaensis. Kinamycin A has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Synonyms: BRN 0505520; 2,3,4-Tri(acetyloxy)-1,2,3,4,6,11-hexahydro-1,7-dihydroxy-3-methyl-6,11-dioxo-5H-benzo(b)carbazole-5-nitrile; 1,2,3-Tris(acetyloxy)-11-diazonio-4,9-dihydroxy-2-methyl-10-oxo-2,3,4,10-tetrahydro-1H-benzo[b]fluoren-5-olate. Grade: >98%. CAS No. 35303-12-9. Molecular formula: C24H20N2O10. Mole weight: 496.42. | |
| Kinamycin B | Kinamycin B is produced by the strain of Str. murayamaensis. Kinamycin B has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Synonyms: BRN 0503790; (1R,2R,3R,4S)-2-acetyloxy-11-diazonio-1,3,4,10-tetrahydroxy-2-methyl-9-oxo-3,4-dihydro-1H-benzo[b]fluoren-5-olate. Grade: >98%. CAS No. 35303-13-0. Molecular formula: C20H16N2O8. Mole weight: 412.35. | |
| Kistamicin A | Kistamicin A is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 and 44. It also has anti-gram-positive bacterial effects. Synonyms: Kistamycin A. CAS No. 155683-50-4. Molecular formula: C61H51ClN8O15. Mole weight: 1171.55. | |
| Kistamicin B | Kistamicin B is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 and 30. Synonyms: Kistamycin B. CAS No. 155683-51-5. Molecular formula: C70H60ClN9O16. Mole weight: 1318.73. | |
| Kitamycin A | It is originally isolated from Strptomyces sp. K385. Kitamycin A can inhibit the activity of plant growth. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Kodaistatin A | Kodaistatin A is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 80 nmol/L. Molecular formula: C35H34O11. Mole weight: 630.64. | |
| Kodaistatin C | Kodaistatin B is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 130 nmol/L. Synonyms: Kodaistatin B. Molecular formula: C35H34O12. Mole weight: 646.64. | |
| Korormicin | It has the effect of resisting Marine gram-negative bacteria, but not against the marine gram-positive bacteria and general bacteria. Synonyms: (3R,4Z,6E)-N-[(5S)-5-Ethyl-5-methyl-2-oxo-2,5-dihydro-3-furanyl]-3-hydroxy-8-[(2S,3R)-3-octyl-2-oxiranyl]-4,6-octadienamid. Molecular formula: C25H39NO5. Mole weight: 433.58. | |
| Kosinostatin | Kosinostatin is originally isolated from Paecilomyces sp. FO-3184. It showed strong anti-gram-positive bacterial activity (MIC of 0.039 μg/mL) and moderate anti-gram-negative bacterial and yeast activity (MIC of 1.56-12.5 μg/mL). It is also poisonous to the cells of a wide variety of tumor cells with the IC50 of 0.02-0.6 μmol/L. And the IC50 of inhibition of DNA topoisomerase IIα is 3-10 μmol/L. Synonyms: Isoquinocycline B. Molecular formula: C33H32N2O10. Mole weight: 616.61. | |
| KS-501 | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Synonyms: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. | |
| KS 502 | It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L. Synonyms: Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 4-carboxy-3-heptyl-5-hydroxyphenyl ester. Grade: >98%. CAS No. 120634-85-7. Molecular formula: C34H48O12. Mole weight: 648.74. | |
| KS 504a | It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L. Synonyms: KS-504a; KS-504b; BRN 4354490; 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)-. CAS No. 122022-77-9. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-504d | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L. Synonyms: KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol. CAS No. 122005-23-6. Molecular formula: C7H4Cl8O2. Mole weight: 403.73. | |
| KS-504e | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L. Synonyms: KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)-. CAS No. 122006-32-0. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-619-1 | It is produced by the strain of Streptomyces californicus KS-619-1. KS-619-1 inhibited Ca2+ and CAM-PDE in bovine brain and heart with an IC50 of 2.0 and 1.5 μmol/L. Synonyms: KS 619-1; Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-8,13-dioxo-3-(2-oxopropyl)-. CAS No. 103370-21-4. Molecular formula: C26H18O9. Mole weight: 474.41. | |
| Kumbicin C | Kumbicin C is a bis-indolyl benzenoid fungal metabolite produced by A. kumbius FRR6049. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 = 0.74 μg/mL) and the Gram-positive bacterium Bacillus subtilis (MIC = 1.6 μg/mL). Synonyms: 5,8-di-1H-indol-3-yl-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol. Grade: ≥95%. CAS No. 1878151-58-6. Molecular formula: C28H24N2O3. Mole weight: 436.50. | |
| Kurasoin A | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin A; (S)-3-Hydroxy-4-(4-hydroxyphenyl)-1-phenyl-2-butanone. CAS No. 182232-62-8. Molecular formula: C16H16O3. Mole weight: 256.30. | |
| Kurasoin B | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin B. Molecular formula: C18H17NO2. Mole weight: 279.33. | |
| Kynapcin-12 | It is produced by the strain of Polyozellus multiplex. It has the activity of inhibiting proline endopeptidase (PEP, EC 3.4.21.26) with IC50 of 1.25 μg/mL. Synonyms: kynapcin 12. Molecular formula: C22H18O8. Mole weight: 410.37. | |
| Kynapcin-13 | It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 76.80 μmol/L. It has a little inhibitory effect on other serine proteases. Synonyms: kynapcin 13. Molecular formula: C12H10O7. Mole weight: 266.20. | |
| Kynapcin-28 | It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 0.98 μmol/L. It has little inhibitory effect on other serine proteases. Synonyms: kynapcin 28. Molecular formula: C19H12O10. Mole weight: 400.29. | |
| L-2,5-Dihydrophenylalanine | It is produced by the strain of Streptomyces sp. L-2,5-Dihydrophenylalanine can cause apoptosis of HL-60 in human myeloblastoid leukemia cells. Synonyms: 2,5-Dihydrophenylalanine; 2,5-dihydrophenyl-L-alanine; L-3-(2,5-Cyclohexadienyl)alanine. CAS No. 16055-12-2. Molecular formula: C9H13NO2. Mole weight: 167.20. | |
| L-2-Hydroxybutyric acid | L-2-Hydroxybutyric acid (CAS# 3347-90-8) is used in method for preparing Cationic Electrodeposition coating compounds. Synonyms: S-2-hydroxybutyric acid. CAS No. 3347-90-8. Molecular formula: C4H8O3. Mole weight: 104.1. | |
| L-671776 | L-671776 is a myo-inositol monophosphatase (IMPase) inhibitor produced by Memnoniella echinata. Synonyms: L 671776; 4,6'-dihydroxy-6-(hydroxymethyl)-2',5',5',8a'-tetramethyl-3',4',4a',5',6',7',8',8a'-octahydro-2'H,3H-spiro[benzofuran-2,1'-naphthalene]-5-carbaldehyde; L-671,776; Spiro(benzofuran-2(3H),1'(2'H)-naphthalene)-5-carboxaldehyde, 3',4',4'a,5',6',7',8',8'a-octahydro-4,6'-dihydroxy-6-(hydroxymethyl)-2',5',5',8'a-tetramethyl-. Grade: >98%. CAS No. 134313-74-9. Molecular formula: C23H32O5. Mole weight: 388.50. | |
| L-681176 | L-681176 is originally isolated from Streptomyces sp. MA 5143a. It has the activity of inhibiting angiotensin transferase. Synonyms: L-681,176. CAS No. 91386-17-3. Molecular formula: C12H23N5O7. Mole weight: 349.34. | |
| L 687781 | L 687781, an inhibitor of β-1,3-D-glucan synthase, is originally isolated from Dictyochaeta simplex. It also has anti-Candida fungal activity and has some effects on Pneumocystis carinii. Synonyms: Hexopyranose, 1,6'-anhydro-1-C-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-O-(6-O-(8-hydroxy-1-oxo-2,4-decadienyl)hexopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-1-oxo-2,4,6,8,10-hexadecapentaenoate). CAS No. 130304-58-4. Molecular formula: C47H66O17. Mole weight: 903.01. | |
| L-696474 | L-696474 is extracted from Hypoxylon fragiforme MF5511. It can competitively inhibit the action of HIV-1 protease with an IC50 of 3 μmol/L. Synonyms: L-696,474; 18-dehydroxycytochalasin H. Grade: >98% by HPLC. CAS No. 141994-72-1. Molecular formula: C30H39NO4. Mole weight: 477.63. | |
| L-783277 | L-783277 is originally isolated from Phoma sp. It inhibits MEK2 with an IC50 of 4 nmol/L. Synonyms: (3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione; LL-783277. Grade: ≥95%. CAS No. 791807-02-8. Molecular formula: C19H24O7. Mole weight: 364.39. | |
| LA-1 | LA-1 is an aliphatic unsaturated ketonic acid produced by Streptomyces kitasatoensis NU-4-4-2. It has anti-gram-positive bacteria activity. CAS No. 61947-93-1. Molecular formula: C10H10O3. Mole weight: 178.18. | |
| Labilomycin | It is produced by the strain of Str. albospoeus var. labilomyceticus A955-y3. It's a sugar antibiotic. It has anti-gram-positive bacteria, mycobacterium activity. It had cytotoxic effect on HeLa cells and Yoshida sarcoma cells. Each rat (Transplantation of airy ascites carcinoma in mice) is given Labilomycin of 250 μg/d, it can inhibit tumor and prolong life. It has a protective effect on mice infected with S. aureus. Serum does not affect its antibacterial activity. Synonyms: Pulvomycin; Oxacyclodocosa-4,7,9,11,15,17,19-heptaene-2,13-dione, 22-[(1S,2S,3S,5E,7E,9E,11S,12S)-12-[(6-deoxy-2,4-di-O-methyl-β-D-galactopyranosyl)oxy]-2,11-dihydroxy-1,3-dimethyl-4-oxo-5,7,9-tridecatrien-1-yl]-6,14-dihydroxy-5,8,12-trimethyl-, (4E,6R,7E,9E,11E,14S,15E,17E,19E,22S)-; (4E,6R,7E,9E,11E,14S,15E,17E,19E,22S)-22-[(1S,2S,3S,5E,7E,9E,11S,12S)-12-[(6-Deoxy-2,4-di-O-methyl-β-D-galactopyranosyl)oxy]-2,11-dihydroxy-1,3-dimethyl-4-oxo-5,7,9-tridecatrien-1-yl]-6,14-dihydroxy-5,8,12-trimethyloxacyclodocosa-4,7,9,11,15,17,19-heptaene-2,13-dione; (-)-Pulvomycin; Antibiotic 1063Z. CAS No. 11006-66-9. Molecular formula: C47H66O13. Mole weight: 839.02. | |
| Laccaridione A | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 14.7, 2.5, 18.8, 7.2 and 18.2, respectively. Synonyms: 10-hydroxy-1,7-dimethoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho(2,3-C)pyran-8,9-dione, 3-((1E)-1,3-dimethyl-1-penten-1-yl)-10-hydroxy-1,7-dimethoxy-. CAS No. 320369-80-0. Molecular formula: C22H24O6. Mole weight: 384.42. | |
| Laccaridione B | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 10.9, 5.1, 8.4, 5.7 and 3.0, respectively. It also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50 (μg/mL) of 2.4, 1.8 and 13.9, respectively. Synonyms: 1-ethoxy-10-hydroxy-7-methoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho[2,3-c]pyran-8,9-dione, 3-[(1E)-1,3-dimethyl-1-pentenyl]-1-ethoxy-10-hydroxy-7-methoxy-. CAS No. 320369-81-1. Molecular formula: C23H26O6. Mole weight: 398.45. | |
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