BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Roseoferin A1 | Roseoferin A1 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity. Molecular formula: C59H108N10O12. Mole weight: 1149.54. |  |
| Roseoferin C2 | Roseoferin C2 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity. Molecular formula: C60H110N10O12. Mole weight: 1163.57. | |
| Roseorubicin A | It is produced by the strain of Actinomyces roseoviolaceus A529. It has anti-gram-positive bacteria and mycobacterium effect, and Roseorubicin A has stronger antibacterial effect than B. It also inhibits leukaemia L1210 with IC50 of 0.04 μg/mL. Synonyms: BRN 1419073. CAS No. 70559-00-1. Molecular formula: C54H78N2O18. Mole weight: 1043.20. | |
| Roseorubicin B | It is produced by the strain of Actinomyces roseoviolaceus A529. It has anti-gram-positive bacteria and mycobacterium effect, and Roseorubicin A has stronger antibacterial effect than B. It also inhibits leukaemia L1210 with IC50 of 0.06 μg/mL. Synonyms: BRN 1417572; 2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-(dimethylamino)-4-O-[2,3,6-trideoxy-3-(dimethylamino)hexopyranosyl]hexopyranoside. CAS No. 70559-01-2. Molecular formula: C36H48N2O11. Mole weight: 684.77. | |
| Roxithromycin | Roxithromycin is a semi-synthetic macrolide antibiotic that inhibits bacterial cell growth and replication. It is used to treat respiratory tract, urinary and soft tissue infections. Synonyms: Roxithromycinum; RU 28965; RU-28965; RU-965; RU965; Rulide; (9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin; Assoral; Brilid; Claramid; Forilin; Overal; Rossitrol; Rotramin; Roxeptin; Roxid; Roxithromycin A; Surlid. Grade: >98%. CAS No. 80214-83-1. Molecular formula: C41H76N2O15. Mole weight: 837.05. | |
| RP-1551-1 | RP-1551-1 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor potentially via reacting with amino groups on the alpha-receptor extracellular domain. Molecular formula: C25H29ClO6. Mole weight: 460.9. | |
| RP-1551-2 | RP-1551-2 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C24H31ClO5. Mole weight: 435. | |
| RP-1551-3 | RP-1551-3 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H27ClO5. Mole weight: 442.9. | |
| RP-1551-4 | RP-1551-4 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H29ClO6. Mole weight: 460.9. | |
| RP-1551-5 | RP-1551-5 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H33ClO5. Mole weight: 449. | |
| RP-1551-6 | RP-1551-6 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H29ClO6. Mole weight: 460.9. | |
| RP-1551-7 | RP-1551-7 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C19H23ClO4. Mole weight: 350.8. | |
| RP-1551-8 | RP-1551-8 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C26H31ClO6. Mole weight: 474.97. | |
| RP-1551-9 | RP-1551-9 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C19H25ClO4. Mole weight: 352.85. | |
| RP-1776 | RP-1776 is a cyclic peptide isolated from the culture broth of Streptomyces sp. KY11784. It selectively inhibits the binding of PDGF BB to the extracellular domain of the PDGF beta-receptor with an IC50 value of 11 ± 6 μmol/L. Synonyms: RP 1776; RP1776. Molecular formula: C75H94N12O20. Mole weight: 1483.61. | |
| RP-66453 | RP-66453 is a secondary peptide metabolite produced by Streptomyces sp. A 9738. It can selectively bind to neurotensin receptor. Synonyms: RP 66453; RP66453. Molecular formula: C33H36N4O8. Mole weight: 616.7. | |
| RP-71955 | RP-71955 is a tricyclic 21 amino acid peptide produced by Streptomyces sp. SP9400. It is active against HIV-1. Synonyms: RP 71955; RP71955. CAS No. 152835-17-1. Molecular formula: C97H131N23O26S4. Mole weight: 2163.5. | |
| RPI856 A | RPI856 A is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856A; RPI-856 A. Molecular formula: C43H61N7O13. Mole weight: 884. | |
| RPI856 B | RPI856 B is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856B; RPI-856 B. Molecular formula: C43H61N7O13. Mole weight: 884. | |
| RPI856 C | RPI856 C is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856Cl RPI-856 C. Molecular formula: C39H56N6O10. Mole weight: 768.9. | |
| RPI856 D | RPI856 D is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856D; RPI-856 D. Molecular formula: C39H56N6O10. Mole weight: 768.9. | |
| RPR113228 | RPR113228 is a farnesyl-protein transferase inhibitor produced by Chrysosporium lobatum. It has no inhibitory effect on squalene synthase. Synonyms: RPR-113228; RPR113228. Molecular formula: C30H49O9P. Mole weight: 584.7. | |
| RS-22A | RS-22A is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 A. Molecular formula: C54H91N3O17. Mole weight: 1054.3. | |
| RS-22B | RS-22B is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 B. Molecular formula: C55H93N3O17. Mole weight: 1068.3. | |
| RS-22C | RS-22C is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 C. Molecular formula: C56H95N3O17. Mole weight: 1082.4. | |
| (R)-Shikonin | (R)-Shikonin is a naphthoquinone extracted from Lithospermum erythrorhizon and Alkanna sp. It is a natural cardioprotective, antioxidative and anti-inflammatory agent. Synonyms: Shikonin; Isoarnebin 4; Tokyo Violet; Shikonin S; (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione; R-5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-pentenyl]-1,4-naphthalenedione; (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone; (+)-Shikonin; (R)-(+)-Shikonin; NSC 252844; Shikonine; Tokyo Violet. Grade: ≥98%. CAS No. 517-89-5. Molecular formula: C16H16O5. Mole weight: 288.30. | |
| Rubeomycin A | It is originally isolated from Actinomadura soseoviolacea var. biwakoensis. Rubeomycin A has the effect of anti-gram-positive bacteria, but not anti-gram-negative bacteria and fungi. It has also been shown to inhibit Yoshida sarcoma cells and leukemia P388 cells. Molecular formula: C33H41NO13. Mole weight: 659.68. | |
| Rubeomycin A1 | It is originally isolated from Actinomadura soseoviolacea var. biwakoensis. Rubeomycin A has the effect of anti-gram-positive bacteria, but not anti-gram-negative bacteria and fungi. The inhibition of A1 of Yoshida sarcoma cells was 10 times higher than that of other components. Molecular formula: C33H41NO13. Mole weight: 659.68. | |
| Rubiginone D2 | Rubiginone D2 is an antibiotic originally isolated from Streptomyces sp. Go N1/5. It has the activity of inhibiting tumor cells. CAS No. 274913-71-2. Molecular formula: C20H16O6. Mole weight: 352.34. | |
| Rubradirin B | Rubradirin B is produced by the strain of Str. achromogenes var. rubradiris. It has the effect of anti-gram-positive bacteria. Grade: >98%. CAS No. 68833-11-4. Molecular formula: C40H33N3O15. Mole weight: 795.70. | |
| (-)-Rugulosin | It is the less common optical isomer of the mycotoxin, (+)-rugulosin. It is first isolated from myrothecium verrucaria. It is a mycotoxin with antiviral activity. Synonyms: Radicalisin; (5aR,6S,13aR,14S,17R,18S,19S,20R)-1,8,9,16,17,20-hexahydroxy-3,11-dimethyl-14-hydro-5H,6H-6,13a,5a,14-(epibutane[1,2,3,4]tetrayl)cycloocta[1,2-b:5,6-b']dinaphthalene-5,7,13,15-tetraone; (1S,1'S,2R,2'R,3S,3'S,9aR,9'aR)-Rugulosin; [5aR-(5aR*,6S*,13aR*,14S*,17R*,18S*,19S*,20R*)]-1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-5H,6H-6,13a,5a,14-[1,2,3,4]butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone. Grade: >98% by HPLC. CAS No. 21884-45-7. Molecular formula: C30H22O10. Mole weight: 542.49. | |
| Rumbrin | Rumbrin is a cytoprotective substance produced by Auxarthron umbrinumn 13. Synonyms: 6-(8-(3-Chloro-1H-pyrrol-2-yl)-1-methyl-1,3,5,7-octatetraenyl)-4-methoxy-3-methyl-2H-pyran-2-one. Grade: >98%. CAS No. 148528-19-2. Molecular formula: C20H20ClNO3. Mole weight: 357.83. | |
| (S)-10,11-Dehydrocurvularin | It is a natural mycotoxin that has cytotoxic activity against select cancer cell lines. It has been shown to activate the heat shock response, block TGF-β signaling, and scavenge superoxide anions. Synonyms: alpha,beta-Dehydrocurvularin; Trans-Dehydrocurvularin; (S)-10,11-dehydrocurvularin; (10E,15S)-10,11-Dehydrocurvularin; (4S,8E)-4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione; (4S,8E)-4beta-Methyl-11,13-dihydroxy-1,4,5,6,7,10-hexahydro-2H-3-benzoxacyclododecin-2,10-dione; α,β-dehydro Curvularin. Grade: ≥98%. CAS No. 21178-57-4. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| S14-95 | S14-95 is an inhibitor of the JAK/STAT pathway isolated from Penicillium sp. 14-95. It inhibits the IFN-gamma mediated expression of the reporter gene with IC50 values of 2.5 to approximately 5 mg/ml. It inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 5 microg/ml (10.8 mM) in LPS/IFN-gamma stimulated J774 mouse macrophages. Molecular formula: C28H34O5. Mole weight: 450.57. | |
| S-15183a | S-15183a is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. It also inhibited endogenous SPH kinase activity in intact platelets. Synonyms: S-15183 a. Molecular formula: C25H36O5. Mole weight: 416.5. | |
| S-15183b | S-15183b is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. Synonyms: S-15183 b. Molecular formula: C27H40O5. Mole weight: 444.6. | |
| S-19159 | S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. Synonyms: S 19159; S19159. Molecular formula: C30H44O5. Mole weight: 484.7. | |
| S-2,3-Dicarboxyaziridine | It is produced by the strain of Streptomyces sp. It has the activity of resistant gram-positive and negative bacteria, especially the Aeromonas salmonecida. Synonyms: 2,3-Dicarboxyaziridine. CAS No. 57528-68-4. Molecular formula: C4H5NO4. Mole weight: 131.09. | |
| (S)-4-Acetamido-5-hydroxypentanoic acid | (S)-4-Acetamido-5-hydroxypentanoic acid. Molecular formula: C7H13NO4. Mole weight: 175.2. | |
| (S)-4-Benzamido-5-hydroxypentanoic acid | (S)-4-Benzamido-5-hydroxypentanoic acid. CAS No. 1053648-94-4. Molecular formula: C12H15NO4. Mole weight: 237.3. | |
| S-632-B1 | S-632-B1 is an antitumor and antifungal antibiotic produced by Streptomyces hygroscopicus S-632. It inhibits Saccharomyces cerevisiae with MIC of 0.78 μg/mL. Synonyms: Antibiotic S 632-B1; S 632B(sub 1); Antibiotic S 632B(sub 1). CAS No. 121995-32-2. Molecular formula: C17H25NO5. Mole weight: 323.4. | |
| S-632-B2 | S-632-B2 is an antitumor and antifungal antibiotic produced by Streptomyces hygroscopicus S-632. It inhibits Saccharomyces cerevisiae with MIC of 0.78 μg/mL. It activity is weaker than that of S-632-B1. Synonyms: Antibiotic S 632-B2; S 632B(sub 2); Antibiotic S 632B(sub 2). Molecular formula: C17H25NO5. Mole weight: 323.4. | |
| (S)-a-Benzylmalic acid | (S)-a-Benzylmalic acid is produced by the strain of Penicillum sp. It can be used to inhibit carboxylpeptidase A and slightly inhibit carboxylpeptidase B. Synonyms: (s)-a-benzylmalic acid; (S)-2-Benzyl-2-hydroxybutanedioic acid. CAS No. 51692-93-4. Molecular formula: C11H12O5. Mole weight: 224.21. | |
| Saccharocin | Saccharocin is produced by the strain of Saccharopolyspora sp. AC-3440. It is effective against gram-positive and negative bacteria, and also against aminoglycoside antibiotic-resistant bacteria. Synonyms: KA-5685. CAS No. 86630-31-1. Molecular formula: C21H40N4O12. Mole weight: 540.56. | |
| Safracin A | Safracin A is produced by the strain of Pseudomonas fluorescens A22 (IFO 14128). It has anti-gram-positive bacteria, gram-negative bacteria and anti-tumor effect. Synonyms: Y-16760; 2-Amino-N-[(1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminoisoquinolino[3,2-b][3]benzazocin-9-yl)methyl]propanimidic acid. Grade: >98%. CAS No. 87578-98-1. Molecular formula: C28H36N4O6. Mole weight: 524.61. | |
| Saframycin A | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. Saframycin A also has weak activity against gram-negative bacteria and mycobacteria. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.0056 μmol/L. Synonyms: (-)-saframycin A; 21-Cyanosaframycin-B; N-[[(6S)-7α-Cyano-1,5,6,7,9,10,13,14,14aα,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6S,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. Grade: 98%. CAS No. 66082-27-7. Molecular formula: C29H30N4O8. Mole weight: 562.57. | |
| Saframycin B | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: Propanamide, N-((1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (6S-(6-alpha,9-beta,14a-alpha,15-alpha))-; N-[[(6S)-1,5,6,7,9,10,13,14,14aα,15-Decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6S,9R,14aS,15R)-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-28-8. Molecular formula: C28H31N3O8. Mole weight: 537.56. | |
| Saframycin C | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. Synonyms: Propanamide, N-((1,5,6,7,9,10,13,14,14a,15-decahydro-2,5,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (5S-(5-alpha,6-alpha,9-beta,14a-alpha,15-alpha))-; N-[[(5S)-1,5,6,7,9,10,13,14,14aα,15-Decahydro-2,5α,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(5S,6R,9R,14aS,15R)-1,5,6,7,9,10,13,14,14a,15-decahydro-2,5,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-29-9. Molecular formula: C29H33N3O9. Mole weight: 567.59. | |
| Saframycin D | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: N-[[(6R)-6,7,9,10,13,14,14aα,15-Octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-((6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (6R-(6-alpha,9-beta,14a-alpha,15-alpha))-. CAS No. 66082-30-2. Molecular formula: C28H31N3O9. Mole weight: 553.56. | |
| Saframycin E | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: Propanamide, N-[[(5S,6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4,5-trihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-31-3. Molecular formula: C28H33N3O9. Mole weight: 555.58. | |
| Saframycin F | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.59 μmol/L. Synonyms: 21-Cyanosaframycin D; N-[[(6R)-7α-Cyano-6,7,9,10,13,14,14aα,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6R,7R,9R,14aS,15R)-7-cyano-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-[(7-cyano-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-oxo-, [6R-(6a,7a,9b,14aa,15a)]-; (+)-Saframycin F. CAS No. 92569-03-4. Molecular formula: C29H30N4O9. Mole weight: 578.57. | |
| Saframycin G | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.03 μmol/L. Synonyms: 14-Hydroxysaframycin A; Propanamide, N-[[(5S,6R,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-[(7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-oxo-, [5S-(5a,6a,7a,9b,14aa,15a)]-; (-)-Saframycin G; Propanamide, N-((7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1-4-10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (5S-(5alpha,6alpha,7alpha,9beta,14aalpha,15alpha))-. CAS No. 92569-02-3. Molecular formula: C29H30N4O9. Mole weight: 578.57. | |
| Saframycin H | It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.033 μmol/L. Synonyms: 25-Dihydro-25-beta-ketopropylsaframycin A; Pentanamide, N-[(7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-hydroxy-2-methyl-4-oxo-, (1R,2S,10R,13S)-. CAS No. 92569-01-2. Molecular formula: C32H36N4O9. Mole weight: 620.65. | |
| Saframycin Mx1 | It is produced by the strain of Myxococcus xanthus. It has anti-gram-positive bacteria and gram-negative bacteria effects. Synonyms: Saframycin Mx-1; Propanamide, 2-amino-N-((6,7,9,10,13,14,14a,15-octahydro-1,4,7-trihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-, (5S-(5-alpha,6-beta,7-alpha,9-beta(R*),14a-alpha,15-beta))-; 2-Amino-N-[[[(5S)-6,7,9,10,13,14,14aα,15-octahydro-1,4,7α-trihydroxy-2,5α,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin]-9β-yl]methyl]propionamide; Propanamide, 2-amino-N-[[(5S,6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4,7-trihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-. CAS No. 113036-78-5. Molecular formula: C29H38N4O9. Mole weight: 586.63. | |
| Saframycin Mx2 | It is produced by the strain of Myxococcus xanthus. It has anti-gram-positive bacteria and gram-negative bacteria effects. Synonyms: (S)-2-Amino-N-[[[(5S)-6,7,9,10,13,14,14aα,15-octahydro-1,4-dihydroxy-2,5α,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin]-9β-yl]methyl]propionamide; Saframycin Mx-2; Propanamide, 2-amino-N-[[(5S,6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-; Propanamide, 2-amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-, [5S-[5a,6a,9b(R*),14aa,15a]]-. CAS No. 113036-79-6. Molecular formula: C29H38N4O8. Mole weight: 570.63. | |
| Sakyomicin A | It is a benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. In vivo, 10 mg/kg of Sakyomicin A had no effect against sarcoma 180A and leukemia P338 cells. Synonyms: Benz[A]anthracene-1,7,12(2H)-trione, 3,4,4A,12B-tetrahydro-2,3,4A,8-tetrahydroxy-3-methyl-12B-[[2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-, (2S,3R,4as,12br)-; SKM; (2S)-3,4,4a,12b-Tetrahydro-2β,3α,4aβ,8-tetrahydroxy-3-methyl-12bβ-[[(2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]benz[a]anthracene-1,7,12(2H)-trione. CAS No. 86413-75-4. Molecular formula: C25H26O10. Mole weight: 486.47. | |
| Sakyomicin B | It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. Synonyms: (2S)-3,4,4a,12b-Tetrahydro-2β,3α,4aβ,8,12bβ-pentahydroxy-3-methylbenz[a]anthracene-1,7,12(2H)-trione; Benz(a)anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, (2S-(2-alpha,3-beta,4a-alpha,12b-alpha))-; Antibiotic SEN 136A; Antibiotic WP 3688-1; Antibiotic PD 116198; (+)-Sakyomicin B. CAS No. 86470-27-1. Molecular formula: C19H16O8. Mole weight: 372.33. | |
| Sakyomicin C | It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. In vivo, 6 mg/kg of Sakyomicin C had no effect against sarcoma 180A and leukemia P338 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-3,4a,8-trihydroxy-3-methyl-12b-[[(2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-, (3R,4aS,12bR)-; Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-3,4a,8-trihydroxy-3-methyl-12b-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)oxy]-, [3R-[3a,4ab,12bb(2R*,5R*,6R*)]]-. CAS No. 86413-76-5. Molecular formula: C25H26O9. Mole weight: 470.47. | |
| Sakyomicin D | It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,5,6,12b-hexahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, (2S,3R,4aR,12bR)-; Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,5,6,12b-hexahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, [2S-(2a,3b,4aa,12ba)]-. CAS No. 86413-77-6. Molecular formula: C19H18O8. Mole weight: 374.34. | |
| Salfredin A3 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-53-3. Molecular formula: C18H19NO9. Mole weight: 393.30. | |
| Salfredin A4 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-54-4. Molecular formula: C15H15NO7. Mole weight: 321.28. | |
| Salfredin A7 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-55-5. Molecular formula: C16H17NO7. Mole weight: 335.31. | |
| Salfredin B11 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. Synonyms: 6H-Furo(3,4-g)-1-benzopyran-6-one, 2,8-dihydro-5-hydroxy-2,2-dimethyl-; 2,8-Dihydro-5-hydroxy-2,2-dimethyl-6H-furo(3,4-g)-1-benzopyran-6-one; 9-Hydroxy-6,6-dimethyl-3,6-dihydro-2,5-dioxa-cyclopenta[b]naphthalen-1-one. Grade: 98% by HPLC. CAS No. 165467-63-0. Molecular formula: C13H12O4. Mole weight: 232.23. | |
| Salfredin C1 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-56-6. Molecular formula: C13H11NO6. Mole weight: 277.23. | |
| Salfredin C2 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-57-7. Molecular formula: C15H13NO8. Mole weight: 335.26. | |
| Salfredin C3 | It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-58-8. Molecular formula: C16H15NO8. Mole weight: 349.29. | |
| Samarosporin | It is a peptide antibiotic produced by the strain of Samarospora sp. No. F-7762. It has anti-bacterial, yeast, fungi and protozoa effects, but the effect is not strong. The serum can reduce its activity. CAS No. 60304-25-8. Molecular formula: C71H107N15O18. Mole weight: 1458.70. | |
| Sangivamycin hydrochloride | Sangivamycin hydrochloride is a nucleoside (purine) antibiotic produced by the strain of Str. rimosus BA-90912. 0.02-0.05 μg/mL of Sangivamycin inhibits HeLa cells. It has weak inhibitory effect on sarcoma-180 and adenocarcinoma 755 in mice. It has obvious inhibitory effect on leukemia L-1210. When intraperitoneally administered, the drug binds to nucleic acids in tissues in mice through phosphorylation. Synonyms: Sangivamycin monohydrochloride; 7H-Pyrrolo(2,3-d)pyrimidine-5-carboxamide, 4-amino-7-beta-D-ribofuranosyl-, monohydrochloride; 7-Deazaadenosine-7-carboxamide hydrochloride. Grade: 95%. CAS No. 21090-35-7. Molecular formula: C12H15N5O5.HCl. Mole weight: 345.74. | |
| Sanglifehrin A | It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin A to Cyclophilin is 10-20 times stronger than Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay. Synonyms: SFA; (-)-sanglifehrin A; 19-Oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone, 18-[(1E,3E,7S,8S)-9-[(2S,3R,4S,5S,6R,9S,11S)-9-ethyl-4-hydroxy-3,5,11-trimethyl-8-oxo-1-oxa-7-azaspiro[5.5]undec-2-yl]-8-hydroxy-1,7-dimethyl-1,3-nonadienyl]-10,12-dihydroxy-3-[(3-hydroxyphenyl)methyl]-11-methyl-6-(1-methylethyl)-9-(3-oxobutyl)-, (3S,6S,9R,10R,11S,12S,13E,15E,18S,21S)-. CAS No. 187148-13-6. Molecular formula: C60H91N5O13. Mole weight: 1090.39. | |
| Sanglifehrin B | It is a cyclophilin combination produced by the strain of Streptomyces sp. A92-308110. The affinity of Sanglifehrin B to Cyclophilin is 10-20 times stronger than Cyclosporin A. The immunosuppressive effect of Sanglifehrin is lower than Cyclosporin A by mixed lymphocyte reaction assay. Synonyms: SFB. Molecular formula: C60H89N5O12. Mole weight: 1072.37. | |
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