BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| [Ala17]-MCH acetate | [Ala17]-MCH is a melanin-concentrating hormone receptor agonist with EC50 values of 17 and 54 nM at MCH1 and MCH2 receptors. Molecular formula: C99H159N29O28S4. Mole weight: 2331.76. |  |
| (Ala1)-PAR4 (1-6) amide (mouse) trifluoroacetate salt | (Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). Synonyms: AY-NH2; AYPGKF-NH2; H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2; PAR4-AP; Proteinase-Activated Receptor 4 Activating Peptide; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide trifluoroacetate salt. Grade: ≥95%. Molecular formula: C34H48N8O7·xCF3COOH. Mole weight: 680.79. | |
| (Ala1)-PAR4 (1-6) (mouse) trifluoroacetate salt | (Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60. Synonyms: H-Ala-Tyr-Pro-Gly-Lys-Phe-OH; L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine trifluoroacetate salt. Grade: ≥95%. Molecular formula: C34H47N7O8·xCF3COOH. Mole weight: 681.78. | |
| (αR)-α-[(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzeneacetamide | (αR)-α-[(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzeneacetamide, commonly referred to as TGBO, is an indispensible compound widely utilized in the realm of biomedical research. Its significance lies in its pivotal role as a tool for investigating the treatment of diverse diseases and facilitating drug development. Uses: (r)-prunasin intermediate. CAS No. 207512-68-3. Molecular formula: C22H27NO11. Mole weight: 481.45. | |
| (αR,βR)-rel-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol | One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: Voriconazole (2R,3R)-Isomer; Voriconazole 3-Epimer; (2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S); Voriconazole Impurity 12. CAS No. 137234-76-5. Molecular formula: C16H13ClF3N5O. Mole weight: 383.76. | |
| (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic Acid Ethyl Ester | (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic Acid Ethyl Ester is used in the synthesis of Paclitaxel, which is a chemotherapy medication used to treat a number of types of cancer. Uses: Used in the synthesis of paclitaxel metabolite. Synonyms: tert-butyl ((1S,2R)-1-(4-(benzyloxy)phenyl)-2-hydroxy-3-oxohexyl)carbamate; Paclitaxel Impurity 100; Ethyl (2R,3S)-3-[4-(benzyloxy)phenyl]-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoate; Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-4-(phenylmethoxy)-, ethyl ester, (αR,βS)-. Grade: ≥95%. CAS No. 382596-26-1. Molecular formula: C23H29NO6. Mole weight: 415.48. | |
| (αR,βS)-β-(Acetylamino)-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic Acid Ethyl Ester | (αR,βS)-β-(Acetylamino)-α-hydroxy-4-(phenylmethoxy)-benzenepropanoic Acid Ethyl Ester is one of Paclitaxel impurities. Paclitaxel is a tetracyclic diterpenoid isolated originally from the Pacific yew tree Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. It has a role as a microtubule-stabilising agent, a metabolite, a human metabolite and an antineoplastic agent. Uses: Used in the synthesis of paclitaxel metabolite. Synonyms: (alphaR,betaS)-beta-(Acetylamino)-alpha-hydroxy-4-(phenylmethoxy)-benzenepropanoic Acid Ethyl Ester. Grade: > 98%. CAS No. 382596-25-0. Molecular formula: C20H23NO5. Mole weight: 357.40. | |
| (αS)-α-[(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzeneacetamide | (αS)-α-[(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzeneacetamide, a compound widely utilized in the biomedical sector, plays a pivotal role in the therapeutic approach for a diverse range of ailments by acting as an efficacious inhibitor or catalyst. Synonyms: Benzeneacetamide, α-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-, (αS)-. CAS No. 1840963-44-1. Molecular formula: C22H27NO11. Mole weight: 481.45. | |
| (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester hydrochloride | An intermediate of Carfilzomib, which is a second-generation proteasome inhibitor for the treatment of relapsed and refractory multiple myeloma. Synonyms: L-Phenylalanine, (αS)-α-aminobenzenebutanoyl-L-leucyl-, methyl ester, hydrochloride (1:1); H-hPhe-Leu-Phe-OMe.HCl; L-homophenylalanyl-L-leucyl-L-phenylalanine methyl ester hydrochloride; Methyl ((S)-2-amino-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate hydrochloride; Carfilzomib KSM; Carfilzomib main chain; Methyl (αS)-α-aminobenzenebutanoyl-L-leucyl-L-phenylalanine hydrochloride. Grade: ≥95%. CAS No. 1960444-13-6. Molecular formula: C26H35N3O4.HCl. Mole weight: 490.04. | |
| (αS)-N-[(1R,4R)-4-Amino-5-phenyl-1-(phenylmethyl)pentyl]-α-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]-4-morpholinebutanamide | An impurity of Cobicistat, a cytochrome P450 3A (CYP3A) inhibitor used for the treatment of HIV/AIDS infection. Grade: 90%. CAS No. 1992785-25-7. Molecular formula: C35H50N6O3S. Mole weight: 634.88. | |
| (αZ)-2-Amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic Acid | (αZ)-2-Amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic Acid can be used in the synthesis of Aztreonam, a synthetic monocyclic β-lactam antibiotic. Synonyms: Aztreonam impurity 15. Grade: 95%. CAS No. 102507-85-7. Molecular formula: C9H11N3O5S. Mole weight: 273.26. | |
| [Arg14,Lys15]Nociceptin | [Arg14,Lys15]Nociceptin behaves as a highly potent agonist of the OP(4) receptor (EC50 = 1 nM) and is able to produce long-lasting effects in vivo, compared with the natural ligand NC. It exhibits > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-OH; [Arg(14),Lys(15)]NC. CAS No. 236098-40-1. Molecular formula: C82H137N31O22. Mole weight: 1909.18. | |
| [Arg14,Lys15]Nociceptin TFA | [Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist with an EC50 of 1 nM. It displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively. Molecular formula: C84H138F3N31O24. Mole weight: 2023.18. | |
| [Asp5,Gly9-OH]-Atosiban | An impurity of Atosiban. Atosiban is a synthetic peptide that acts as a selective oxytocin receptor antagonist, primarily used to delay preterm labor in pregnant women. Synonyms: Mpr-DTyr(Et)-Ile-Thr-Asp-Cys-Pro-Orn-Gly(Mpr1&Cys6 bridge); deamino-Cys-D-Tyr(Et)-Ile-Thr-Asp-Cys-Pro-Orn-Gly (Disulfide bridge: Cys1-Cys6); Deamino-cysteinyl-O4-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-alpha-aspartyl-L-cysteinyl-L-prolyl-L-ornithyl-glycine (1->6)-disulfide; [Asp5,Gly9]-Atosiban; Asp5,Gly9-Atosiban; Asp5 Gly9 Atosiban; Asp5,Gly9-OH-Atosiban. Grade: ≥95%. CAS No. 2014351-17-6. Molecular formula: C43H65N9O14S2. Mole weight: 996.16. | |
| [Asp5]-Oxytocin acetate | [Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analog possessing significant biological activity. [Asp5]-Oxytocin acetate can induce uterine contractions in rats in vitro and can be enhanced by Mg2+. Synonyms: Cys-Tyr-Ile-Gln-Asp-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6). Molecular formula: C45H69N11O15S2. Mole weight: 1068.22. | |
| (β)-1-D-Ribofuranosyl-3-guanylurea | (α)-1-D-Ribofuranosyl-3-guanylurea is a labile hydrolysis product of the antitumor nuceloside 5-Azacytidine. Synonyms: N-(Aminoiminomethyl)-N'-β-D-ribofuranosylurea; 1-β-D-Ribofuranosyl-3-guanylurea; NSC 264412; 1-(Diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea; 3-Carbamimidoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea. Grade: 96 %. CAS No. 2508-80-7. Molecular formula: C7H14N4O5. Mole weight: 234.21. | |
| [betaAla-D-Cit]-Cetrorelix | An impurity of Cetrorelix. Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist used primarily in reproductive medicine and oncology. It works by competitively binding to GnRH receptors, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn prevents ovulation and reduces the production of sex steroids. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-beta-Ala-DCit-Leu-Arg-Pro-DAla-NH2; [β-Ala-D-Cit]-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-β-Ala-D-Cit-Leu-Arg-Pro-D-Ala-NH2; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-beta-alanyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide; betaAla-DCit-Cetrorelix; betaAla-D-Cit-Cetrorelix. Grade: ≥95%. Molecular formula: C73H97ClN18O15. Mole weight: 1502.14. | |
| [betaAla-Leu]-Cetrorelix | An impurity of Cetrorelix. Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist used primarily in reproductive medicine and oncology. It works by competitively binding to GnRH receptors, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn prevents ovulation and reduces the production of sex steroids. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-beta-Ala-Leu-Arg-Pro-DAla-NH2; [β-Ala-Leu]-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-β-Ala-Leu-Arg-Pro-D-Ala-NH2; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-beta-alanyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide; betaAla-Leu-Cetrorelix. Grade: ≥95%. Molecular formula: C73H97ClN18O15. Mole weight: 1502.14. | |
| (beta)-Estradiol 17-acetate | β-Estradiol 17-acetate is a metabolite of estradiol. Synonyms: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate. Grade: >98%. CAS No. 1743-60-8. Molecular formula: C20H26O3. Mole weight: 314.42. | |
| (βS,δS)-Atorvastatin tert-Butyl Ester | (βS,δS)-Atorvastatin tert-Butyl Ester is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: (3S,5S)-tert-butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate; 2-Methyl-2-propanyl (3S,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate; (βS,δS)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester. CAS No. 1428118-12-0. Molecular formula: C37H43FN2O5. Mole weight: 614.75. | |
| (Chloromethyl)cyclohexane | (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor. Synonyms: 1-Chloromethylcyclohexane; Cyclohexylmethyl chloride; Cyclohexane, (chloromethyl)-. Grade: >95%. CAS No. 1072-95-3. Molecular formula: C7H13Cl. Mole weight: 132.63. | |
| (cis)-phenyl 3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate | An impurity of Paroxetine which is a selective serotonin reuptake inhibitor. Synonyms: Paroxetine Impurity 24. Grade: >95%. CAS No. 105812-85-9. Molecular formula: C26H24FNO5. Mole weight: 449.48. | |
| [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide | A Y5 receptor-selective agonist (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1-0.15 nM). Synonyms: GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY. CAS No. 313988-89-5. Molecular formula: C183H281N57O54S2. Mole weight: 4207.67. | |
| (Cys(S)²)-Octreotide trifluoroacetate salt | Trisulfide Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: H-D-Phe-Cys(S)-Phe-D-Trp-Lys-Thr-Cys-L-threoninol trifluoroacetate salt (Trisulfide bond); Trisulfide Octreotide trifluoroacetate salt. Grade: 95%. | |
| [d5]-Ethyl b-D-glucuronide | [d5]-Ethyl b-D-glucuronide is a paramount and unparalleled biochemical compound, diligently employed within the biomedical industry as a powerful tool to delve into the intricate realm of drug metabolism and pharmacokinetics. This intriguing compound assumes the role of a remarkably stable isotope-labeled internal standard, flawlessly navigating the labyrinthine glucuronidation pathways. Synonyms: d5-Ethyl-b-D-6-glucuronide; d5-Ethyl b-D-glucuronide. Molecular formula: C8H9D5O7. Mole weight: 227.22. | |
| (D-Ala2,D-Leu5)-Enkephalin Trifluoroacetate | (D-Ala2,D-Leu5)-Enkephalin is a prototypical δ-opioid receptor agonist with antinociceptive activity. It also exhibits activity at the μ-opioid receptor. Synonyms: L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-D-leucine trifluoroacetic acid; (D-Ala2,D-Leu5)-Enkephalin TFA salt; DADLE TFA salt. Molecular formula: C31H40F3N5O9. Mole weight: 683.67. | |
| [D-ala2]-Liraglutide | [D-ala2]-Liraglutide is a derivative of Liraglutide, a long-acting analog of glucagon-like peptide-1 (GLP-1) receptor which could protect b-cells from apoptosis under conditions associated with the development of type 1 and type 2 diabetes. Synonyms: D-ala2-Liraglutide; H-His-D-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(1)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.palmitoyl-Glu(1)-OH. Molecular formula: C172H265N43O51. Mole weight: 3751. | |
| (Dap22)-ShK | (Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Synonyms: (DAP22)-SHK; ShK-Dap22. Grade: > 97%. CAS No. 220384-25-8. Molecular formula: C166H268N54O48S7. Mole weight: 4012.8. | |
| [D-Arg30]-Semaglutide | [D-Arg30]-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81R)-54-(((6R,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grade: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| [D-Arg8]-Cetrorelix | [D-Arg8]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-DArg-Pro-DAla-NH2; D-Arg8-Cetrorelix; (D-Arg8)-Cetrorelix; D-Arg(8)-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-D-Arg-Pro-D-Ala-NH2; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-D-arginyl-L-prolyl-D-alaninamide. Grade: ≥95%. CAS No. 3031679-78-1. Molecular formula: C70H92ClN17O14. Mole weight: 1431.06. | |
| [D-Cit(Ac)6]Cetrorelix | [D-Cit(Ac)6]Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit(Ac)-Leu-Arg-Pro-DAla-NH2; DCit(Ac)-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit(Ac)-Leu-Arg-Pro-D-Ala-NH2; D-Cit(Ac)6-Cetrorelix; D-Cit(Ac)-Cetrorelix; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N-acetyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide; N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-[(acetylamino)carbonyl]-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide. Grade: ≥95%. CAS No. 1631741-33-7. Molecular formula: C72H94ClN17O15. Mole weight: 1473.07. | |
| [D-Cys]-Lanreotide | [D-Cys]-Lanreotide is an impurity of Lanreotide, which is a somatostatin analogue with antineoplastic activity. Synonyms: D2Nal-Cys-Tyr-DTrp-Lys-Val-DCys-Thr-NH2(Cys2&Cys7 bridge); H-DPhe-cyclo[DPen-Tyr-DTrp-Lys-Val-Cys]-Thr-NH2; 3-(2-Naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-D-cysteinyl-L-threoninamide (2->7)-disulfide; D2Nal-CY-DTrp-KV-DCys-T-NH2(Cys2&Cys7 bridge); H-D-2Nal-Cys-Tyr-D-Trp-Lys-Val-D-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7); D-Cys7-Lanreotide; [D-Cys7]-Lanreotide; D-Cys(7)-Lanreotide; Lanreotide Impurity A; D-Cys-7 Lanreotide; BIM-23255; L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-D-cysteinyl-, cyclic (2→7)-disulfide; H-D-2Nal-Cys-Tyr-D-Trp-Lys-Val-D-Cys-Thr-NH2 (Disulfide bridge between cysteines); Lanreotide impurity 17. Grade: ≥95%. CAS No. 205234-53-3. Molecular formula: C54H69N11O10S2. Mole weight: 1096.33. | |
| [Des-Ac-D-2Nal]-Cetrorelix | An impurity of Cetrorelix. Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist used primarily in reproductive medicine and oncology. It works by competitively binding to GnRH receptors, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn prevents ovulation and reduces the production of sex steroids. Synonyms: D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-Pro-DAla-NH2; Des-Ac-D2NalCetrorelix; D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2; 4-Chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide; Des-Ac-D2Nal-Cetrorelix; [Des-Ac-D-2Nal]1-Cetrorelix. Grade: ≥95%. Molecular formula: C55H79ClN16O12. Mole weight: 1191.79. | |
| [Des-D-Ala-NH2]-Cetrorelix | An impurity of Cetrorelix. Cetrorelix is a gonadotropin-releasing hormone (GnRH) antagonist used primarily in reproductive medicine and oncology. It works by competitively binding to GnRH receptors, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn prevents ovulation and reduces the production of sex steroids. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-Pro; Des-DAla-NH2-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-OH; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-proline; [Des-D-Ala-NH2]10-Cetrorelix; Des-D-Ala-Cetrorelix; 1-9 Acid Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Proline. Grade: ≥95%. CAS No. 2901757-75-1. Molecular formula: C67H86ClN15O14. Mole weight: 1360.97. | |
| [Des-Gly9-NH2]-Atosiban | An impurity of Atosiban. Atosiban is a synthetic peptide that acts as a selective oxytocin receptor antagonist, primarily used to delay preterm labor in pregnant women. Synonyms: Mpr-DTyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn(Mpr1&Cys6 bridge); deamino-Cys-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-OH (Disulfide bridge: Cys1-Cys6); Deamino-cysteinyl-O4-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparagyl-L-cysteinyl-L-prolyl-L-ornithine (1->6)-disulfide; Atosiban impurity C; Des-(Gly9-NH2)-Atosiban; Des-Gly9-NH2-Atosiban; L-Ornithine, O-ethyl-N-(3-mercapto-1-oxopropyl)-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-, cyclic (1→5)-disulfide. Grade: ≥95%. CAS No. 168102-71-4. Molecular formula: C41H63N9O12S2. Mole weight: 938.12. | |
| [Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grade: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
| [des-Thr-ol8]-D-Cys7-octreotide | [des-Thr-ol8]-D-Cys7-octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: H-D-Phe-Cys(1)-Phe-D-Trp-Lys-Thr-D-Cys(1)-ol; H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-D-Cys-ol (Disulfide bridge: Cys2-Cys7). Molecular formula: C45H57N9O9S2. Mole weight: 932.13. | |
| [Des-Thr-ol]8-Des-D-Trp4-Octreotide | An impurity of Octreotide. Octreotide is a synthetic long-acting cyclic octapeptide that inhibits growth hormone, glucagon and insulin more effectively than somatostatin. Synonyms: DPhe-Cys-Phe-Lys-Thr-Cys(Cys2&Cys6 bridge); DPhe-CF-KTC(Cys2&Cys6 bridge); [Des-Thr-ol]8-[Des-D-Trp]4-Octreotide; [Des-Thr-ol8]-[Des-D-Trp4]-Octreotide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-L-lysyl-L-threonyl-L-cystine (2->6)-disulfide; D-Phenylalanyl-L-cystyl-L-phenylalanyl-L-lysyl-L-threonyl-L-cystine (Disulfide Bridge between Cys2-Cys6); H-D-Phe-Cys-Phe-Lys-Thr-Cys-OH (Disulfide bridge: Cys2-Cys6). Grade: ≥95%. Molecular formula: C34H47N7O8S2. Mole weight: 745.91. | |
| [D-Glu3]-Semaglutide | [D-Glu3]-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: (3R,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81R)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grade: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| (D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt | (D-Glycero-a-D-manno-heptopyranosyl)-dihydrogenphosphate cyclohexylammonium salt, a notable compound within the biomedical sector for its extensive utilization in research based studies, can be employed in examining aspects related to the biosynthesis of heptose-containing antibiotics, for example, tunicamycin. Molecular formula: C7H15O10P.C6H13N. Mole weight: 389.34. | |
| (D-Glycero-α-D-manno-heptopyranosyl)-dihydogenphosphate, Cyclohexylammonium Salt | Key intermediate in the metabolism of sugars and their transformation to nucleotides. Also a potential inhibitor for the heptose synthetase, an enzyme of the biosynthesis of the inner core region of lipopolysaccharides. Contains 1-2 equivalents of cyclohexylamine. Synonyms: Cyclohexanamine; [(2R,3S,4S,5S,6R)-6-[(1R)-1,2-dihydroxyethyl]-3,4,5-trihydroxyoxan-2-yl] dihydrogen phosphate; Cyclohexanamine--1-O-phosphono-alpha-D-manno-heptopyranose (1/1); (D-Glycero-?-D-manno-heptopyranosyl)-dihydogenphosphate, Cyclohexylammonium Salt; Cyclohexanamine (2R,3S,4S,5S,6R)-6-((R)-1,2-dihydroxyethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl phosphate. CAS No. 359435-45-3. Molecular formula: C13H28NO10P. Mole weight: 389.34. | |
| [D-Ile]3-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DIle-DLys-Pip; D-Phe-D-Phe-D-Ile-D-Lys-Pip; ffik-Pip; 1-(D-Phenylalanyl-D-phenylalanyl-D-isoleucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Ile3-Difelikefalin; [D-Ile]3-Difelikefalin; [D-Ile3]-Difelikefalin; D-Ile-Difelikefalin; N1-(D-Phenylalanyl-D-phenylalanyl-D-isoleucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Ile-D-Lys-4-amino-4-piperidinecarboxylic acid. Grade: ≥95%. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
| [disulphonic-acid]-Desmopressin | An impurity of Desmopressin. Desmopressin is a synthetic analogue of the hormone vasopressin, used to treat conditions such as central diabetes insipidus, nocturnal enuresis (bedwetting), and certain bleeding disorders like hemophilia A and von Willebrand disease. Synonyms: Mpr(SO3H)-Tyr-Phe-Gln-Asn-Cys(acid)-Pro-DArg-Gly-NH2; Mpr(SO3H)-YFQN-Cys(acid)-P-DArg-G-NH2; Mpa(SO3H)-Tyr-Phe-Gln-Asn-Cys(SO3H)-Pro-D-Arg-Gly-NH2; deamino-Cys(SO3H)-Tyr-Phe-Gln-Asn-Cys(SO3H)-Pro-D-Arg-Gly-NH2; Deamino-cysteinyl(SO3H)-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl(SO3H)-L-prolyl-D-arginyl-glycinamide. Grade: ≥95%. Molecular formula: C46H66N14O18S2. Mole weight: 1167.23. | |
| (DL)-3-O-Methyldopa (Levodopa Related Compound B) | Impurity of Levodopa. Synonyms: 3-Methoxytyrosine; 3-(4-Hydroxy-3-methoxyphenyl)alanine; 3-(Methoxy)-dl-tyrosine; 4-Hydroxy-3-methoxyphenylalanine; DL-3-Methoxy-4-hydroxyphenylalanine. Grade: > 95%. CAS No. 7636-26-2. Molecular formula: C10H13NO4. Mole weight: 211.22. | |
| (D-Leu6,Pro-NHEt9)-LHRH (4-9) | (D-Leu6,Pro-NHEt9)-LHRH (4-9). Synonyms: L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide; L-Prolinamide, L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-. Grade: ≥95%. CAS No. 202333-85-5. Molecular formula: C37H62N10O8. Mole weight: 774.95. | |
| [D-Lys(Ac)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Ac)-Pip; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-acetyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Ac)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Ac)-Pip; Difelikefalin acetate impurity 15; Lys4(Ac)-Difelikefalin; D-Lys4(Ac)-Difelikefalin; Lys(Ac)-Difelikefalin; Lys(Ac)4-Difelikefalin; [Lys(Ac)]4-Difelikefalin. Grade: ≥95%. Molecular formula: C38H55N7O7. Mole weight: 721.89. | |
| [D-Lys(EA)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(EA)-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-((2-aminoethyl)amino)hexanoyl)piperidine-4-carboxylic acid; Difelikefalin impurity 10; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(2-aminoethyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(EA)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(EA)-Pip; D-Lys4(EA)-Difelikefalin; D-Lys(EA)4-Difelikefalin. Grade: ≥95%. CAS No. 2219351-44-5. Molecular formula: C38H58N8O6. Mole weight: 722.92. | |
| [D-Lys(Ipr)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Ipr)-4-Piperidinecarboxylic acid; Difelikefalin impurity 8; 1-[D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(1-methylethyl)-D-lysyl]-4-amino-4-piperidinecarboxylic acid; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-isopropyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Ipr)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Ipr)-Pip; D-Lys4(Ipr)-Difelikefalin; D-Lys(Ipr)4-Difelikefalin; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-(isopropylamino)hexanoyl)piperidine-4-carboxylic acid. Grade: ≥95%. CAS No. 1024828-90-7. Molecular formula: C39H59N7O6. Mole weight: 721.93. | |
| [D-Lys(Me)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Me)-4-Piperidinecarboxylic acid; Difelikefalin impurity 5; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-methyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-methyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(Me)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Me)-Pip; D-Lys4(Me)-Difelikefalin; D-Lys(Me)4-Difelikefalin. Grade: ≥95%. CAS No. 1024828-78-1. Molecular formula: C37H55N7O6. Mole weight: 693.88. | |
| [D-Lys(Propylamine)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(Propylamine)-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-2-((R)-2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-4-methylpentanamido)-6-((3-aminopropyl)amino)hexanoyl)piperidine-4-carboxylic acid; Difelikefalin impurity 11; D-Phe-D-Phe-D-Leu-D-Lys(Propylamine)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(Propylamine)-Pip; D-Lys4(Propylamine)-Difelikefalin; D-Lys(Propylamine)4-Difelikefalin; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(3-aminopropyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid. Grade: ≥95%. CAS No. 2219351-45-6. Molecular formula: C39H60N8O6. Mole weight: 736.94. | |
| [D-Lys(tBu)]4-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: DPhe-DPhe-DLeu-DLys(tBu)-4-Piperidinecarboxylic acid; Difelikefalin impurity 16; 1-(N2-D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(tert-butyl)-D-lysyl)-4-aminopiperidine-4-carboxylic acid; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-N6-(tert-butyl)-D-lysyl)-4-amino-4-piperidinecarboxylic acid; D-Phe-D-Phe-D-Leu-D-Lys(tBu)-4-amino-4-piperidinecarboxylic acid; ffl-DLys(tBu)-Pip; D-Lys4(tBu)-Difelikefalin; D-Lys(tBu)4-Difelikefalin. Grade: ≥95%. Molecular formula: C40H61N7O6. Mole weight: 735.96. | |
| (D)-(+)-Neopterin | Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Neopterin is synthesized in response to interferon-γ stimulation, and used as a marker of T helper cell-induced immune activation. Neopterin is also an indicator of oxidative stress, and modulates the effects of reactive oxygen species (ROS). Synonyms: 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; Neopterin; 2-Amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)pteridine; 2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)-4(8H)-pteridone; 6-D-erythro-Neopterin; D-(+)-Neopterin; D-erythro-Neopterin. Grade: ≥98% by HPLC. CAS No. 2009-64-5. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
| [D-Orn6]-Cetrorelix | [D-Orn6]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: D-Orn6-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Orn-Leu-Arg-Pro-D-Ala-NH2; (S)-1-(((S)-2-((S)-2-((S)-2-((R)-2-((R)-2-((R)-2-acetamido-3-(naphthalen-2-yl)propanamido)-3-(4-chlorophenyl)propanamido)-3-(pyridin-3-yl)propanamido)-3-hydroxypropanamido)-3-(4-hydroxyphenyl)propanamido)-5-aminopentanoyl)-L-leucyl-L-arginyl)-N-((R)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide. Molecular formula: C69H91ClN16O13. Mole weight: 1388.04. | |
| [D-Phe12]-Bombesin | [D-Phe12]-Bombesin is a bombesin receptor antagonist inhibiting bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Synonyms: [D-Phe12]-Bombesin; 12-Phe-bombesin; Bombesin, phe(12)-; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2; Bombesin, phenylalanine(12)-; (D-Phe12)-Bombesin; Bombesin, 12-D-phenylalanine; AKOS024456850; PD079209. CAS No. 108437-87-2. Molecular formula: C74H112N22O18S. Mole weight: 1629.9. | |
| [D-Phe12,Leu14]-Bombesin | [D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist. It inhibits bombesin binding to rat brain (IC50 = 2 μM), inhibits amylase release in vitro (IC50 = 4 μM), and attenuates bombesin-mediated suppression of food intake in vivo. Synonyms: [D-Phe12,Leu14]-Bombesin; 108437-88-3; PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2; (D-Phe12,Leu14)-Bombesin; AKOS024457621; PD079499; HY-103287; CS-0027153. CAS No. 108437-88-3. Molecular formula: C75H114N22O18. Mole weight: 1610.9. | |
| [D-Phe12,Leu14]-Bombesin acetate | [D-Phe12,Leu14]-Bombesin is a bombesin receptor antagonist. It inhibits bombesin binding to rat brain (IC50 = 2 μM), inhibits amylase release in vitro (IC50 = 4 μM), and attenuates bombesin-mediated suppression of food intake in vivo. Molecular formula: C77H118N22O20. Mole weight: 1671.89. | |
| [D-Phe((βR)-Me)]1-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: beta-RMe-DPhe-DPhe-DLeu-DLys-4-Piperidinecarboxylic acid; 4-Amino-1-((R)-6-amino-2-((R)-N-((2R,3R)-2-amino-3-phenylbutanoyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamido)hexanoyl)piperidine-4-carboxylic acid; 4-Amino-1-(((2R,3R)-2-amino-3-phenylbutanoyl)-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic acid; Difelikefalin impurity 9; [beta-RMe-D-Phe]1-Difelikefalin; [β-(R)-Me-D-Phe]1-Difelikefalin; [D-Phe(βR-Me)]1-Difelikefalin. Grade: ≥95%. CAS No. 2756592-19-3. Molecular formula: C37H55N7O6. Mole weight: 693.88. | |
| [D-Phe(EA)]1-Difelikefalin | An impurity of Difelikefalin. Difelikefalin is a kappa opioid receptor (KOR) agonist used to treat moderate to severe pruritus (itching) associated with chronic kidney disease (CKD) in patients undergoing hemodialysis. Synonyms: Ethylamine-DPhe-DPhe-DLeu-DLys-4-Piperidinecarboxylic acid; 4-Amino-1-((2R,5R,8R,11R)-14-amino-2-(4-aminobutyl)-8,11-dibenzyl-5-isobutyl-4,7,10-trioxo-3,6,9,12-tetraazatetradecan-1-oyl)piperidine-4-carboxylic acid; 4-Amino-1-((2-aminoethyl)-D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic acid; Difelikefalin impurity 12; D-Phe(EA)-D-Phe-D-Leu-D-Lys-4-amino-4-piperidinecarboxylic acid; f(EA)flk-Pip; D-Phe1(EA)-Difelikefalin; D-Phe(EA)1-Difelikefalin. Grade: ≥95%. CAS No. 2219351-61-6. Molecular formula: C38H58N8O6. Mole weight: 722.92. | |
| (D)-PPA 1 | PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo. Synonyms: H-D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe-OH. Grade: ≥95%. CAS No. 1620813-53-7. Molecular formula: C70H98N20O21. Mole weight: 1555.67. | |
| [D-Pro9]-Cetrorelix | [D-Pro9]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-DPro-DAla-NH2; D-Pro9-Cetrorelix; [D-Pro]9-Cetrorelix; D-Pro(9)-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-D-Pro-D-Ala-NH2; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-D-prolyl-D-alaninamide. Grade: ≥95%. CAS No. 3031679-75-8. Molecular formula: C70H92ClN17O14. Mole weight: 1431.06. | |
| [D-Ser4]-Cetrorelix | [D-Ser4]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: D-Ser4-Cetrorelix; (D-Ser4)-Cetrorelix; D-Ser(4)-Cetrorelix; D-Ser-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-D-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2; Ac-D2Nal-D4Cpa-D3Pal-DSer-Tyr-DCit-Leu-Arg-Pro-DAla-NH2; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-D-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide. Grade: ≥95%. CAS No. 3031679-89-4. Molecular formula: C70H92ClN17O14. Mole weight: 1431.06. | |
| [D-Thr5]-Liraglutide | [D-Thr5]-Liraglutide is a derivative of Liraglutide, a long-acting analog of glucagon-like peptide-1 (GLP-1) receptor which could protect b-cells from apoptosis under conditions associated with the development of type 1 and type 2 diabetes. Synonyms: D-Thr5-Liraglutide; H-His-Ala-Glu-Gly-D-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(1)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.palmitoyl-Glu(1)-OH. Molecular formula: C172H265N43O51. Mole weight: 3751. | |
| [D-Trp11]-Neurotensin | [D-Trp11]-Neurotensin is an analogue of Neurotensin (NT). It is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can also inhibit NT-induced hypotension. CAS No. 73634-68-1. Molecular formula: C80H122N22O19. Mole weight: 1695.96. | |
| [D-Trp34]-Neuropeptide Y | [D-Trp34]-Neuropeptide Y is a potent and selective NPY Y(5) receptor agonist (pEC50= 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively), with > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Unlike the prototype selective NPY Y(5) receptor agonist [D-Trp(32)]NPY, [D-Trp(34)]NPY markedly increases food intake in rats, an effect that is blocked by the selective NPY Y(5) receptor antagonist CGP 71683A. Synonyms: Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-D-Trp-Arg-Tyr-NH2. CAS No. 153549-84-9. Molecular formula: C196H289N55O56. Mole weight: 4311.77. | |
| [D-Trp 7,9,10]-Substance P | [D-Trp 7,9,10]-Substance P is a substance P analog that blocks activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors. Synonyms: Gpantagonist-2A; GPAnt-2 analog. CAS No. 89430-38-6. Molecular formula: C79H105N21O13S. Mole weight: 1588.89. | |
| (E)-1-(2-Aminoethylidene)-6-methoxyindan | (E)-1-(2-Aminoethylidene)-6-methoxyindan is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the production of ramelteon. Synonyms: (E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine; (2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine. CAS No. 178676-73-8. Molecular formula: C12H15NO. Mole weight: 189.25. | |
| (E)-1-Benzyl-4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridinium Chloride | (E)-1-Benzyl-4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridinium Chloride is used as a reactant in the preparation of Donepezil, which is a highly specific reversible acetylcholinesterase (AChE) inhibitor used to treat moderate to severe Alzheimer's disease. Synonyms: 1-Benzyl-4-[(E)-(5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl]pyridinium chloride; Pyridinium, 4-[(E)-(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]-1-(phenylmethyl)-, chloride (1:1). Grade: ≥95%. CAS No. 1188913-39-4. Molecular formula: C24H22ClNO3. Mole weight: 407.89. | |
| (E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine | (E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia). Uses: Intermediate in the preparation of ramelteon. Synonyms: 2-[(8E)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-ylidene]ethan-1-amine; 2-[(E)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene]ethylamine. Grade: >95%. CAS No. 196597-61-2. Molecular formula: C13H15NO. Mole weight: 201.26. | |
| (E)-2-(5-(cyanoimino)-1-propylpyrrolidin-2-yl)acetic acid | An impurity of Pramipexole which is an agonist of dopamine receptor D2, D3 and D4, especially used as D2-receptor agonist. Synonyms: N-Propyl-2S-cyanimidopyrrolidine-5-acetic Acid; Pramipexole Related Compound. CAS No. 1373869-89-6. Molecular formula: C10H15N3O2. Mole weight: 209.24. | |
| (E)-2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)acetonitrile | (E)-2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)acetonitrile is an impurity of agomelatine, an atypical antidepressant used to treat major depressive disorder. Synonyms: (2E)-(7-Methoxy-3,4-dihydro-1(2H)-naphthalenylidene)acetonitrile. CAS No. 127299-26-7. Molecular formula: C13H13NO. Mole weight: 199.25. | |
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