BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
N-Formyl-Met-Leu-Phe, also called as fMLP, is an endogenous chemotactic peptide for polymorphonuclear leukocyte and a specific ligand of N-formyl peptide receptor (FPR) (Ki = 38 nM). Synonyms: L-Phenylalanine, N-formyl-L-methionyl-L-leucyl-; fMLP; N-Formyl-MLF; Formyl-MLF; For-Met-Leu-Phe-OH; Chemotactic peptide; L-Phenylalanine, N-[N-(N-formyl-L-methionyl)-L-leucyl]-; N-Formyl-L-methionyl-L-leucyl-L-phenylalanine; N-Formyl-Met-Leu-Phe-OH; N-Formyl-methionyl-leucyl-phenylalanine; NSC 350593. Grades: ≥98%. CAS No. 59880-97-6. Molecular formula: C21H31N3O5S. Mole weight: 437.55.
N-Formyl-Met-Leu-Phe-Lys
N-Formyl-Met-Leu-Phe-Lys is a potent and selective agonist of FPR1. Synonyms: Fmlfk; For-Met-Leu-Phe-Lys-OH; N-formyl-L-methionyl-L-leucyl-L-phenylalanyl-L-lysine; formyl-MLFK-OH; (5S,8S,11S,14S)-14-(4-aminobutyl)-11-benzyl-5-formamido-8-isobutyl-6,9,12-trioxo-2-thia-7,10,13-triazapentadecan-15-oic acid. Grades: ≥95%. CAS No. 67247-11-4. Molecular formula: C27H43N5O6S. Mole weight: 565.73.
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a formyl peptide receptor (FPR) agonist. Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH; F-chemotactic peptide; N-Formyl-NLE-LF-NLE-YK; N-formyl-L-norleucyl-L-leucyl-L-phenylalanyl-L-norleucyl-L-tyrosyl-L-lysine; N-Formyl hexapeptide; (3S,6S,9S,12S,15S,18S)-18-(4-Aminobutyl)-9-benzyl-3,12-dibutyl-15-(4-hydroxybenzyl)-6-isobutyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oic acid. Grades: ≥95% by HPLC. CAS No. 71901-21-8. Molecular formula: C43H65N7O9. Mole weight: 824.02.
N-Glycolyl Ademethionine Trifluoroacetic Acid
N-Glycolyl Ademethionine is an Ademethionine derivative, and acts as a SAM-II riboswitch aptamer, regulating gene expression in response to essential metabolites. Synonyms: (((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((S)-3-(2-aminoacetamido)-3-carboxypropyl)(methyl)sulfonium Trifluoroacetic Acid. Molecular formula: C19H26F3N7O7S xC2HF3O2. Mole weight: 553.51.
A useful protective group in antibody drug conjugates. Synonyms: Azidoacetic acid NHS ester;(2,5-Dioxopyrrolidin-1-yl) 2-azidoacetate. Grades: ≥98%. CAS No. 824426-32-6. Molecular formula: C6H6N4O4. Mole weight: 198.13.
NHS-Carboxy-dT
NHS-Carboxy-dT, a derivative widely utilized for nucleotide modification in molecular biology and pharmaceutics, boasts a multitude of functions. Not only is it advantageous for labeling antibodies and DNA, but it's also adept in the synthesis of oligonucleotide probes. With its versatile applications, NHS-Carboxy-dT has even been implemented in the creation of nucleotide therapeutics as a viable treatment choice for illnesses such as cancer and hereditary conditions. Grades: >95% by HPLC. Molecular formula: C46H52N5O12P. Mole weight: 897.92.
NHS-PEG4-azide
NHS-PEG4-azide is a non-cleavable 4-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs). Synonyms: Azido-PEG4-CH2CO2-NHS; N3-PEG4-C2-NHS ester; N3-PEG4-CH2CH2COONHS Ester; Azido-PEG4-NHS ester; N-Succinimidyl 15-Azido-4,7,10,13-tetraoxapentadecanoate; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate; 1-[(1-Azido-15-oxo-3,6,9,12-tetraoxapentadecan-15-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(15-azido-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)oxy]-. Grades: ≥98%. CAS No. 944251-24-5. Molecular formula: C15H24N4O8. Mole weight: 388.37.
N-hydroxy-5-norbornene-2.3-dicarboxylimide
N-hydroxy-5-norbornene-2.3-dicarboxylimide is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs. Synonyms: 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione; N-Hydroxy-5-norbornene-2,3-dicarboximide; 3,5-Dioxo-4-azatricyclo[5.2.1.02'6]dec-8-en-4-ol; HONB; N-Hydroxy-5-bicyclo[2.2.1]heptene-2,3-dicarboximide; N-Hydroxy-5-norbornene-2,3-dicarboximide; NSC 100740; NSC 12953; Endo-N-Hydroxy-5-Norbornene-2; N-Hydroxynorborna-5-ene-2,3-dicarbimide; N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide; SCHEMBL6052; Oprea1_006565; HONB. Grades: 98 % (HPLC). CAS No. 21715-90-2. Molecular formula: C9H9NO3. Mole weight: 179.17.
Nicotinamide-beta-D-riboside H-L-tartrate
Nicotinamide-beta-D-riboside H-L-tartrate is a cutting-edge compound, finding remarkable applicability in the comprehensive research of diverse pathological states, comprising metabolic abnormalities, neuropathologies and mitochondrial impairments. It diligently assumes the role of a bioavailable precursor, effectively replenishing nicotinamide adenine dinucleotide (NAD+), an indispensably pivotal coenzyme instrumental in governing cellular energetics and orchestrating seamless DNA mending. Synonyms: 3-Carbamoyl-1-(beta-D-ribofuranosyl)-pyridinium 2,3-dihydroybutanedioate(2S)(1:1). Molecular formula: C15H20N2O11. Mole weight: 404.33.
Nicotinamide guanine dinucleotide sodium salt
Nicotinamide guanine dinucleotide sodium salt, acting as a formidable coenzyme by intricately partaking in a multitude of biochemical reactions. Its profound utility extends to the research of energy metabolism-related afflictions, encompassing mitochondrial disorders and maladies stemming from oxidative stress. Synonyms: 1- ( (2R, 3R, 4S, 5R) -5- ( ( ( ( ( ( ( (2R, 3S, 4R, 5R) -5- (2-amino-6-oxo-1, 6-dihydro-9H-purin-9-yl) -3, 4-dihydroxytetrahydrofuran-2-yl) methoxy) (hydroxy) phosphoryl) oxy) oxidophosphoryl) oxy) methyl) -3, 4-dihydroxytetrahydrofuran-2-yl) -3-carbamoylpyridin-1-ium sodium salt (1:x); NGD sodium salt. Molecular formula: C21H27N7O15P2.xNa. Mole weight: 679.42 (free acid).
Nicotinamide Riboside Triflate (α/β mixture)
Nicotinamide analog, Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide). Uses: Nicotinamide analog. nicotinamide riboside (β-nar) is an intermediate in one biosynthetic pathway by which nicotamide is converted into nad (nicotinamide adenine dinucleotide) cas 1341-23-7 for free base form. Synonyms: 3-(Aminocarbonyl)-1-D-ribofuranosylpyridinium Trifluoromethanesulfonic Acid Salt;Nicotinamide Ribose Triflate; Nicotinamide Ribonucleoside Triflate; NAR; Ribosylnicotinamide Triflate. Grades: 97%. CAS No. 445489-49-6. Molecular formula: C12H15F3N2O8S. Mole weight: 404.32.
Nicotinic Acid Adenine Dinucleotide
Nicotinic Acid Adenine Dinucleotide is an analog of β-Nicotinamide Adenine Dinucleotide; a coenzyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate groups. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(trihydrogen diphosphate), P'?5'-ester with 3-carboxy-1-β-D-ribofuranosylpyridinium, inner salt; 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide, 5'-ester with adenosine 5'-pyrophosphate, inner salt; Pyridinium, 3-carboxy-1-β-D-ribofuranosyl-, hydroxide, 5'?5'-ester with adenosine 5'-(trihydrogen pyrophosphate), inner salt; 1: PN: WO2006081329 PAGE: 47 claimed sequence; Adenine-nicotinic Acid Dinucleotide; Codehydrogenase I, carboxy deamido analog; Codehydrogenase I, nicotinic acid analog; Deamido-NAD; Deamidodiphosphopyridine Nucleotide; Desamido NAD; Nicotinate Adenine Dinucleotide; Nicotinic Acid-adenine Dinucleotide. CAS No. 6450-77-7. Molecular formula: C21H26N6O15P2. Mole weight: 664.41.
Nicotinic Acid Riboside
An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells. Synonyms: 3-Carboxy-1-β-D-ribofuranosylpyridinium Inner Salt; 3-Carboxy-1-β-D-ribofuranosyl-pyridinium Hydroxide Inner Salt; Nicotinic Acid Ribonucleoside; Nicotinic Riboside. Grades: 97%. CAS No. 17720-18-2. Molecular formula: C11H13NO6. Mole weight: 255.22.
Analogue of an effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells. Synonyms: 3-(Methoxycarbonyl)-1-β-D-ribofuranosyl-pyridinium. Grades: 90%. Molecular formula: C13H16F3NO9S. Mole weight: 419.33.
N-Isobutyrylguanosine
N-Isobutyrylguanosine is used in the syntehsis of 2'-O-(o-nitrobenzyl)-3'-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis. Synonyms: N2-iso-Butyrylguanosine; N2-Isobutyrylguanosine; N-(2-methylpropanoyl)guanosine; N-(2-Methyl-1-oxopropyl)guanosine; N-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-methylpropanamide. Grades: ≥ 95 %. CAS No. 64350-24-9. Molecular formula: C14H19N5O6. Mole weight: 353.33.
[Nle11]-Substance P
[Nle11]-Substance P is an analogue of Substance P, which can avoid methionine oxidation problems. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Synonyms: substance P NleNH2(11); Substance P [Nle11]; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2; L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl-L-norleucinamide. Grades: ≥95%. CAS No. 57462-42-7. Molecular formula: C64H100N18O13. Mole weight: 1329.59.
NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. Uses: Excitatory amino acid agonists. Synonyms: LC488A; LC 488A; LC-488A. Grades: >98%. CAS No. 6384-92-5. Molecular formula: C5H9NO4. Mole weight: 147.13.
N-Me-Lys(Boc)-OMe HCl
Cas No. 2044710-91-8. Molecular formula: C13H27ClN2O4. Mole weight: 310.82.
N-Methyl-L-prolinol (CAS# 34381-71-0) is a reagent used in the synthesis of novel 4-hydroxytamoxifen analogs used as estrogen-related receptor γ (ERRγ) inverse agonists. Synonyms: (S)-(-)-1-Methyl-2-pyrrolidinemethanol; (S)-(1-methylpyrrolidin-2-yl)methanol. CAS No. 34381-71-0. Molecular formula: C6H13NO. Mole weight: 115.17.
N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea
Reagent for the guanylation of amines. Synonyms: 1,3-Bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea; 1,3-di-Boc-2-methylisothiourea. Grades: ≥ 98 % (TLC). CAS No. 107819-90-9. Molecular formula: C12H22N2O4S. Mole weight: 290.38.
N,N-Dimethylguanosine 5'-Monophosphate is commonly found in eukaryotic tRNA. In addition, the presence of methyl groups on this molecule limits the potential to form proper Watson-Crick base pairing and therefore, it is a useful tool to elucidate molecular events related to post-translational modifications of RNA. Synonyms: N,N-dimethyl-guanosine 5'-(Dihydrogen Phosphate); N,N-Dimethyl-guanosine 5'-Phosphate; N,N-Dimethylguanine 9-β-D-ribofuranoside 5'-Monophosphate; N,N-Dimethylguanosine 5'-Phosphate; N,N-Dimethylguanylic Acid; N2,N2-Dimethylguanine 9-β-D-Ribofuranoside 5'-Phosphoric Acid Ester; N2,N2-Dimethylguanylic Acid. CAS No. 4214-21-5. Molecular formula: C12H18N5O8P. Mole weight: 391.27.
N,N'-Disuccinimidyl carbonate
N,N'-Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N'-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity. Synonyms: 1,1'-[Carbonylbis(oxy)]bis-2,5-pyrrolidinedione; 1-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]oxy]-2,5-pyrrolidinedione; Bis(2,5-dioxopyrrolidin-1-yl) Carbonate; Bis(N-succinimidyl) Carbonate; Bis(succinimidyl) Carbonate; Carbonic Acid bis(2,5-dioxopyrrolidin-1-yl) Ester; Di(2,5-dioxopyrrolidin-1-yl) Carbonate; Disuccimidyl carbonate; Disuccinimidyl Carbonate; N,N-Disuccinimidyl Carbonate; N,N'-Disuccinimido Carbonate; DSC; N-Succinimidyl carbonate; EINECS 277-730-3. Grades: 99 % (HPLC). CAS No. 74124-79-1. Molecular formula: C9H8N2O7. Mole weight: 256.17.
Used for preparation of an inhibitor of the NLS-derived BC peptides. Synonyms: N-Methoxymethylamine hydrochloride. Grades: ≥ 99 % (GC). CAS No. 6638-79-5. Molecular formula: C2H7NO·HCl. Mole weight: 97.55.
Norleual
Norleual, an angiotensin IV analog, competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes. It is also an AT4 receptor antagonist, which disrupts LTP stabilization. Synonyms: L-Norleucyl-L-tyrosyl-L-leucyl-ψ(ch2-nh)-L-histidyl-L-prolyl-L-phenylalanine. CAS No. 334994-34-2. Molecular formula: C41H58N8O7. Mole weight: 774.95.
NoxA1ds
NoxA1ds, a peptide recapitulating a putative activation subdomain of NOXA1, is a highly efficacious and selective inhibitor of Nox1 activity and establishes a critical interaction site for Nox1:NOXA1 binding required for enzyme activation. Synonyms: Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2. CAS No. 1435893-78-9. Molecular formula: C50H88N14O15. Mole weight: 1125.33.
NPC 15199
NPC 15199 is an amino acid derivative. It is also one of the novel PPARγ ligands that can reduce osteoclasts differentiation through activating PPAR&gamma. Synonyms: NPC 15199; NPC15199; NPC-15199; N-(9-Fluorenylmethoxycarbonyl)-L-leucine. Grades: ≥99% by HPLC. CAS No. 35661-60-0. Molecular formula: C21H23NO4. Mole weight: 353.42.
NPE-caged-GTP
NPE-caged-GTP is a valuable tool in biomedical research, specifically in the field of cell signaling. It is a caged derivative of GTP, typically used to study GTPase-dependent processes. Upon irradiation, NPE-caged-GTP releases GTP, facilitating the activation of GTPases involved in various cellular pathways. This product enables precise spatiotemporal control of GTPase activity, aiding in the investigation of diseases like cancer and neurodegenerative disorders. Synonyms: Guanosine-5'-triphosphate, P3-(1-(2-nitrophenyl)-ethyl)-ester. Grades: ≥ 95 % by HPLC. CAS No. 124830-99-5. Molecular formula: C18H23N6O16P3(free acid). Mole weight: 672.33 (free acid).
NPE-caged-GTP sodium salt
NPE-caged-GTP sodium salt is a revolutionary and indispensable tool utilized to probe the intricate dynamics of GTP-dependent intracellular mechanisms. Facilitating meticulous regulation and optical manipulation of GTP signaling pathways, this exceptional compound serves as an invaluable resource for comprehensive studies on signal transduction, protein synthesis and gene expression. Its invaluable application further extends to the exploration of deleterious afflictions linked to GTPases, notably encompassing cancer, neurodegenerative disorders and cardiovascular ailments. Grades: 95%. Molecular formula: C18H23N6O16P3·xNa. Mole weight: 672.33 (free acid).
N-Phenyl Guanosine 2',3',5'-Triacetate
It could be used in the synthesis of C-2 substituted adenosines. Synonyms: 2',3',5'-Tri-O-acetyl-2-N-penylguanosine. CAS No. 53296-13-2. Molecular formula: C22H23N5O8. Mole weight: 485.45.
NPOM-Caged deoxythymidine
NPOM-Caged deoxythymidine is a biomedical product commonly used for the controlled release of deoxythymidine (dT). With precise light activation, this compound delivers dT to target sites aiding in the research of DNA-related disorders and cancer. Harnessing the photolabile properties of NPOM, this caged compound offers a controlled and targeted approach for drug delivery. CAS No. 942218-73-7. Molecular formula: C20H23N3O10. Mole weight: 465.42.
N-(tert-butylphenoxyacetyl)-5'-O-DMT-2'-O-methylguanosine 3'-CE phosphoramidite, a highly indispensable asset in the realm of biomedicine, is extensively employed as a foundational component for nucleic acid synthesis, predominantly in the domain of RNA investigational studies. This remarkable resource facilitates meticulous RNA sequence customization and delineation, leading to a comprehensive comprehension of RNA's intricate constitution, operational mechanism, and its pivotal association with ailments such as cancer and viral infections. Synonyms: DMT-2'O-Methyl-rG(tac) Amidite; DMT-2'O-Methyl-rG(tac) Phosphoramidite. Molecular formula: C53H64N7O10P. Mole weight: 990.09.
NUAK family SNF1-like kinase 2 (446-455) is a peptide derived from NUAK family SNF1-like kinase 2. NUAK family SNF1-like kinase 2 induces cell-cell detachment by increasing F-actin conversion to G-actin. Synonyms: Omphalocele kinase 2 (446-455).
Nuclear pore complex protein Nup98 (315-360)
Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment of the nuclear pore complex (NPC) protein. Synonyms: Ac-Met-Gly-Leu-Phe-Gly-Val-Thr-Gln-Ala-Ser-Gln-Pro-Gly-Gly-Leu-Phe-Gly-Thr-Ala-Thr-Asn-Thr-Ser-Thr-Gly-Thr-Ala-Phe-Gly-Thr-Gly-Thr-Gly-Leu-Phe-Gly-Gln-Thr-Asn-Thr-Gly-Phe-Gly-Ala-Val. Grades: >98%. Molecular formula: C190H288N50O64S. Mole weight: 4328.68.
Nuclear transcription factor Y subunit gamma (275-282)
Nuclear transcription factor Y subunit gamma (275-282) is a 8-aa peptide. Nuclear transcription factor Y subunit gamma is a component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. Synonyms: CAAT box DNA-binding protein subunit C (275-282); Nuclear transcription factor Y subunit C (275-282).
Nuclear transcription factor Y subunit gamma (28-37)
Nuclear transcription factor Y subunit gamma (28-37) is a 10-aa peptide. Nuclear transcription factor Y subunit gamma is a component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. Synonyms: CAAT box DNA-binding protein subunit C (28-37); Nuclear transcription factor Y subunit C (28-37).
Nucleocidin
Nucleocidin is originally isolated from Str. calvus T 3018 and it is mainly resistant to bacteria, mycoplasma and protozoa. Synonyms: 4'-Fluoro-5'-O-sulfamoyladenosine; Antibiotic T-3018; 4'-C-Fluoroadenosine 5'-sulfamate; NSC 521007. Grades: >98%. CAS No. 24751-69-7. Molecular formula: C10H13FN6O6S. Mole weight: 364.31.
Nucleoprotein 118-126
It is a 9-aa peptide, a fragment of Nucleoprotein. Synonyms: NP (118-126); H-Arg-Pro-Gln-Ala-Ser-Gly-Val-Tyr-Met-OH; L-arginyl-L-prolyl-L-glutaminyl-L-alanyl-L-seryl-glycyl-L-valyl-L-tyrosyl-L-methionine. Grades: ≥95%. CAS No. 124454-83-7. Molecular formula: C43H69N13O13S. Mole weight: 1008.15.
Nucleoprotein (265-273)
Nucleoprotein (265-273) is amino acids 265 to 273 fragment of Nucleoprotein. The highly conserved internal nucleoprotein (NP) is a promising antigen to develop a universal influenza A virus vaccine. Molecular formula: C43H77N15O11. Mole weight: 980.17.
Nucleoprotein 396-404
Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Synonyms: NP 396. Grades: >98%. CAS No. 158475-79-7. Molecular formula: C50H71N13O14. Mole weight: 1078.18.
NY-CO-13 (139-147)
NY-CO-13(187-197) is amino acids 139 to 147 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Synonyms: Cellular Tumor Antigen p53 (139-147); Tumor Suppressor p53 (139-147); Tp53 (139-147).
NY-CO-13 (187-197)
NY-CO-13 (187-197) is amino acids 187 to 197 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Synonyms: Cellular Tumor Antigen p53 (187-197); Tumor Suppressor p53 (187-197).
NY-ESO-1 (155-163)
NY-ESO-1 (155-163) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (155-163).
NY-ESO-1 (157-165)
NY-ESO-1 (157-165) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (157-165).
NY-ESO-1 (161-180)
NY-ESO-1 (161-180) is a 20-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (161-180).
NY-ESO-1 peptide (1-9)
NY-ESO-1 peptide (1-9) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (1-9).
N-Z-D-Alaninol
N-Z-D-Alaninol (CAS# 61425-27-2) is a useful research chemical compound. Synonyms: Cbz-D-Alaninol; Z-D-Ala-ol; N-Carbobenzoxy-D-alaninol; (R)-2-(Carbobenzoxyamino)-1-propanol; (R)-Benzyl (1-hydroxypropan-2-yl)carbamate. CAS No. 61425-27-2. Molecular formula: C11H15NO3. Mole weight: 209.24.
It is a coupling agent for peptide synthesis and is particularly suitable for fragment condensation without racemization. Synonyms: TPTU; 2-(2-Pyridon-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; O-(2-Oxo-1(2H)pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; o-(1,2-dihydro-2-oxo-1-pyridyl)-n,n,n',n'-tetramethyluronium tetrafluoroborate; MFCD00075475; AK170016; Methanaminium, N-[(dimethylamino)[(2-oxo-1(2H)-pyridinyl)oxy]methylene]-N-methyl-, tetrafluoroborate(1-) (1:1). Grades: 99 % (HPLC). CAS No. 125700-71-2. Molecular formula: C10H16N3O2.BF4. Mole weight: 297.06.
O- ( ( (2R, 3S, 5R) -5- (6-Benzamido-9H-purin-9-yl) -3- ( (tert-butyldimethylsilyl) oxy) tetrahydrofuran-2-yl) methyl) O-(2-cyanoethyl) O-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) phosphorothioate is a agent that is commonly used in the treatment of certain types of cancer such as leukemia and lymphoma. It works by inhibiting certain enzymes and pathways within the cancer cells, which helps to slow or even stop the growth and spread of cancerous cells throughout the body. Synonyms: O- ( ( (2R, 3S, 5R) -5- (6-benzamido-9H-purin-9-yl) -3- ( (tert-butyldimethylsilyl) oxy) tetrahydrofuran-2-yl) methyl) O- (2-cyanoethyl) O- ( (2R, 3R, 4R, 5R) -5- (2, 4-dioxo-3, 4-dihydropyrimidine-1 (2) -yl) -2- (hydroxymethyl) -4-methoxytetrahydrofuran-3-thiophosphate. Molecular formula: C36H47N8O11PSSi. Mole weight: 858.93.
O4-Me-dT-CE Phosphoramidite
O4-Me-dT-CE Phosphoramidite is a vital tool used for the synthesis of modified DNA strands. It facilitates the introduction of O4-Methyl and 5'-CE modifications into thymidine residues. This product finds extensive applications in research of DNA repair mechanisms and DNA methylation patterns in diseases like cancer. Synonyms: 5'-Dimethoxytrityl-O4-methyl-2'-deoxyThymidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 1-[3-O-[Diisopropylamino(2-cyanoethoxy)phosphino]-5-O-(4,4'-dimethoxytrityl)-2-deoxy-beta-D-erythro-pentofuranosyl]-4-methoxy-5-methylpyrimidine-2(1H)-one. CAS No. 130583-06-1. Molecular formula: C41H51N4O8P. Mole weight: 758.85.
O6-(2-Hydroxy-1-methylethyl)-2'-deoxyguanosine
O6-(2-Hydroxy-1-methylethyl)-2'-deoxyguanosine is a mutagenic O6-alkylguanine adduct that induces mismatch repair-mediated toxicity. Synonyms: O6-(2-Hydroxy-1-methylethyl)-2'-deoxyguanosine; 1327339-21-8; (2R,3R,5R)-5-[2-amino-6-(1-hydroxypropan-2-yloxy)purin-9-yl]-2-(hydroxymethyl)oxolan-3-ol; DTXSID00857793; 9-(2-Deoxy-beta-D-threo-pentofuranosyl)-6-[(1-hydroxypropan-2-yl)oxy]-9H-purin-2-amine. CAS No. 1327339-21-8. Molecular formula: C13H19N5O5. Mole weight: 325.32.
O6-(2-Hydroxyethyl)-2'-deoxyguanosine
A DNA adduct from N-nitrosodiethanolamine and related β-oxidized nitrosamines. It is produced by nitrosamine bident carcinogens. Synonyms: 2'-Deoxy-6-O-(2-hydroxyethyl)guanosine; OHEdG. Grades: 98%. CAS No. 111447-35-9. Molecular formula: C12H17N5O5. Mole weight: 311.29.
O6-(2-Hydroxypropyl)-2'-deoxyguanosine
O6-(2-Hydroxypropyl)-2'-deoxyguanosine is a mutagenic O6-alkylguanine adduct that induces mismatch repair-mediated toxicity. Synonyms: O6-(2-Hydroxypropyl)-2'-deoxyguanosine; 1327339-22-9; (2R,3R,5R)-5-[2-AMINO-6-(2-HYDROXYPROPOXY)PURIN-9-YL]-2-(HYDROXYMETHYL)OXOLAN-3-OL; DTXSID60857835; 9-(2-Deoxy-beta-D-threo-pentofuranosyl)-6-(2-hydroxypropoxy)-9H-purin-2-amine. Grades: 98%. CAS No. 1327339-22-9. Molecular formula: C13H19N5O5. Mole weight: 325.32.
O6-(2-Hydroxypropyl)-2'-deoxyguanosine-d3
Labelled O6-(2-Hydroxypropyl)-2'-deoxyguanosine, a mutagenic O6-alkylguanine adduct that induces mismatch repair-mediated toxicity. Grades: 97%. Molecular formula: C13H16D3N5O5. Mole weight: 328.34.
O6-Chlorophenyl-I CEP
O6-Chlorophenyl-I CEP is a remarkably powerful inhibitor widely employed in the biomedical realm, exhibiting immense potential in the research of diverse ailments such as cancer and inflammation. CAS No. 220382-26-3. Molecular formula: C52H64ClN6O8PSi. Mole weight: 995.63.