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(R)-α,α-Diphenylprolinol Hydrochloride
(R)-α,α-Diphenylprolinol Hydrochloride is the (R)-enantiomer of Diphenylprolinol, which is a norepinephrine-dopamine reuptake inhibitor used as a designer drug. Synonyms: (R)-α,α-Diphenyl-2-pyrrolidinemethanol Hydrochloride; (R)-D2PM Hydrochloride; (2R)-α,α-Diphenyl-2-pyrrolidinemethanol Hydrochloride; α,α-Diphenyl-D-prolinol Hydrochloride. Grade: ≥95%. CAS No. 172152-19-1. Molecular formula: C17H20ClNO. Mole weight: 289.80.
(R)-alpha-Lipoic Acid
(R)-alpha-Lipoic Acid, a vitamin-like organosulfur compound, is widely used as a dietary supplement and antioxidant. It has been also found to influence the activity of nuclear factor kappa-B (NF-κB). Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: (R)-lipoic acid; (+)-alpha-Lipoic acid; (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid; R-(+)-alpha-Lipoic acid; 5-[(3R)-dithiolan-3-yl]pentanoic acid. Grade: 98%. CAS No. 1200-22-2. Molecular formula: C8H14O2S2. Mole weight: 206.318.
(R)-(-)-alpha-Methylhistamine dihydrobromide
(R)-(-)-alpha-Methylhistamine dihydrobromide is a potent and high affinity histamine H3 agonist (KD = 50.3 nM) displaying > 200-fold selectivity over H4 receptors. It inhibits H3-mediated histamine synthesis and release in the CNS at nanomolar concentrations, and induces H4-mediated eosinophil shape change (EC50 = 66 nM). Synonyms: (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide. Grade: ≥99% by HPLC. CAS No. 868698-49-1. Molecular formula: C6H11N3.2HBr. Mole weight: 287.
(R)-Ambrisentan
A metabolite of Ambrisentan. Uses: Antihypertensive agents. Synonyms: (αR)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic Acid. Grade: > 95%. CAS No. 1007358-76-0. Molecular formula: C22H22N2O4. Mole weight: 378.43.
(R)-AminoCarnitine
(R)-AminoCarnitine is an inhibitor of fatty acid oxidation. Uses: Enzyme inhibitors. Synonyms: (2R)-2-Amino-3-carboxy-N,N,N-trimethyl-1-propanaminium Inner Salt; (R)-3-Amino-4-(trimethylammonio)butyrate; Emeriamine. Grade: 95%. CAS No. 98063-21-9. Molecular formula: C7H16N2O2. Mole weight: 160.21.
(R)-Amlodipine Hemi-dibenzoyl-L-tartrate
(R)-Amlodipine Hemi-dibenzoyl-L-tartrate is an impurity of Amlodipine. Amlodipine is a long-acting dihydropyridine L-type calcium channel blocker. Amlodipine is used to lower blood pressure and prevent chest pain. Synonyms: (+)-Amlodipine Hemi-dibenzoyl-L-tartrate; (R)-(+)-Amlodipine Hemi-dibenzoyl-L-tartrate; d-Amlodipine Hemi-dibenzoyl-L-tartrate. CAS No. 890046-37-4. Molecular formula: C20H25ClN2O5.1/2(C18H14O8). Mole weight: 588.02.
(R)-Amlodipine L-tartrate
An impurity of Amlodipine. Amlodipine is a long-acting dihydropyridine L-type calcium channel blocker used to lower blood pressure and prevent chest pain. Synonyms: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4R)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1); Amlodipine (R-isomer) L tartrate; (+)-Amlodipine L-tartrate; (R)-(+)-Amlodipine L-tartrate; (R)-3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate L-tartrate; d-Amlodipine L-tartrate. Grade: ≥95%. CAS No. 2091264-88-7. Molecular formula: C20H25ClN2O5.C4H6O6. Mole weight: 558.96.
(R)-AMPA
(R)-AMPA is an inactive enantiomer of AMPA, which has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor. Synonyms: (R)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. Grade: ≥99% by HPLC. CAS No. 83654-13-1. Molecular formula: C7H10N2O4. Mole weight: 186.17.
(R)-(+)-Anatabine
(R)-(+)-Anatabine is a metabolite of Nicotine, a potent parasympathomimetic stimulant. Synonyms: (+)-Anatabine; (2R)-1,2,3,6-Tetrahydro-2,3'-bipyridine. CAS No. 126454-22-6. Molecular formula: C10H12N2. Mole weight: 160.22.
(R)-Aspartimide
(R)-Aspartimide is a bioactive byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides. Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling. Synonyms: 3-Aminosuccinimide; d-aspartimide. Grade: >95%. CAS No. 404887-22-5. Molecular formula: C4H6N2O2. Mole weight: 114.10.
(R)-(+)-Atenolol
(R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol. Synonyms: (+)-Atenolol; R(+)-Atenolol. Grade: ≥98%. CAS No. 56715-13-0. Molecular formula: C14H22N2O3. Mole weight: 266.3.
(R)-(-)-Atomoxetine-d5 HCl (phenyl-d5)
One of the isotopic labelled form of (R)-(-)-Atomoxetine, which has been found to be a norepinephrine reuptake inhibitor. Synonyms: (R)-Tomoxetine HCl; (R)-N-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine HCl. Grade: 95% by HPLC; 98% atom D. Molecular formula: C17H17D5ClNO. Mole weight: 296.85.
(R)-ATP-beta-S
(R)-ATP-beta-S occupies is an investigatory probe assessing ATP-binding locales. This compound is notorious for its inhibitory function on ATP catalysis. This functional characteristic has manifest and wide-ranging repercussions on maladies including, but not restricted to, malignant neoplasms and neurodegenerative pathologies. Synonyms: (R)-ATPβS; 5'-Adenylic acid, monoanhydride with thiodiphosphoric acid. CAS No. 59261-35-7. Molecular formula: C10H16N5O12P3S. Mole weight: 523.25.
(R)-Azelastine HCl
(R)-Azelastine HCl is the R configuration of Azelastine HCl. Synonyms: (-)-Azelastine Hydrochloride; 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (R)-; (R)-Azelastine Hydrochloride; (R)-4-[(4-Chlorophenyl)Methyl]-2-(hexahydro-1-Methyl-1H-azepin-4-yl)-1(2H)-phthalazin. Grade: > 95%. CAS No. 153408-28-7. Molecular formula: C22H25Cl2N3O. Mole weight: 418.36.
(R)-Azelastine N-Oxide (Mixture of Diastereomers)
(R)-Azelastine N-Oxide (Mixture of Diastereomers) is a metabolite of (R)-Azelastine. Synonyms: (R)-4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1-oxido-1H-azepin-4-yl)-1(2H)-phthalazinone; (-)-Azelastine N-Oxide. Grade: > 95%. CAS No. 1346617-18-2. Molecular formula: C22H24ClN3O2. Mole weight: 397.91.
(R)-BAY1238097
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097, which is an effective and selective BET-histones binding inhibitor with strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models by down-regulating c-MyC levels and its downstream transcriptome. Synonyms: 3H-2,3-Benzodiazepine-3-carboxamide, 4,5-dihydro-7,8-dimethoxy-N,4-dimethyl-1-[4-(4-methyl-1-piperazinyl)phenyl]-, (4R)-; (4R)-7,8-Dimethoxy-N,4-dimethyl-1-[4-(4-methyl-1-piperazinyl)phenyl]-4,5-dihydro-3H-2,3-benzodiazepine-3-carboxamide. Grade: ≥97%. CAS No. 1564269-85-7. Molecular formula: C25H33N5O3. Mole weight: 451.56.
(R)-Bendroflumethiazide
(R)-Bendroflumethiazide is the R-enatiomer of the diuretic Bendroflumethiazide. Synonyms: (3R)-3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide. Grade: > 95%. CAS No. 1087345-31-0. Molecular formula: C15H14F3N3O4S2. Mole weight: 421.42.
(R)-Bepotastine
(R)-bepotastine is an exemplary, potent and selective antagonist of histamine h1 receptors, employed profusely in the research of perennial symptoms of allergic rhinitis, encompassing excessive sneezing, pervasive itching and nasal discharges. Synonyms: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-; 1-Piperidinebutanoic acid, 4-[(R)-(4-chlorophenyl)-2-pyridinylmethoxy]-; (R)-Bepotastine. Grade: > 95%. CAS No. 190730-41-7. Molecular formula: C21H25ClN2O3. Mole weight: 388.90.
(R)-(-)Bicalutamide
(R)-(-)Bicalutamide is an active competitive non-steroidal androgen receptor antagonis. It is the leading antiandrogen, preventing the activation of the androgen receptor and subsequent upregulation of androgen responsive genes by androgenic hormones. It also accelerates the degradation of the androgen receptor. Synonyms: (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; (R)-Casodex; N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Flurophenyl)Thio]-2-Hydroxy-2-Methyl-Propanamide; Propanamide, N-[4-cyano-3-(trifluoromethyl)pheny. Grade: > 95%. CAS No. 113299-40-4. Molecular formula: C18H14F4N2O4S. Mole weight: 430.38.
(R)-BPO-27
(R)-BPO-27, the benzopyrimido-pyrrolo-oxazinedione, is a potent CFTR inhibitor (IC50 = 4 nM) with low-nanomolar potency. Synonyms: (R)-BPO 27; (R)-BPO27. CAS No. 1415390-47-4. Molecular formula: C26H18BrN3O6. Mole weight: 548.34.
(R)-Bromoenol lactone
(R)-Bromoenol lactone is an irreversible inhibitor of iPLA2γ. Synonyms: (R)-BEL; (3R)-6-Ethylidene-3-(naphthalen-1-yl)oxan-2-one; 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one. Grade: ≥98%. CAS No. 478288-90-3. Molecular formula: C16H13BrO2. Mole weight: 317.2.
(R)-Bromoenol lactone-d7
(R)-Bromoenol lactone-d7 ((R)-BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (R)-BEL by GC- or LC-mass spectrometry (MS). Synonyms: (R)-BEL-d7. Grade: ≥99% atom D. Molecular formula: C16H6BrD7O2. Mole weight: 324.2.
(R)-Bufuralol HCl
(R)-Bufuralol HCl is the R-Enantiomer of Bufuralol Hydrochloride. Synonyms: (R)-Bufuralol Hydrochloride; (αR)-α-[[(1,1-Dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol; (+)-Bufuralol Hydrochloride; d-Bufuralol Hydrochloride. Grade: > 95%. CAS No. 57704-11-7. Molecular formula: C16H24NO2Cl. Mole weight: 297.83.
(R)-Butaprost
Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; TR 4978; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid methyl ester. Grade: ≥98%. CAS No. 69648-38-0. Molecular formula: C24H40O5. Mole weight: 408.6.
(R)-Butaprost (free acid)
Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid. Grade: ≥98%. CAS No. 215168-33-5. Molecular formula: C23H38O5. Mole weight: 394.6.
(R)-Cangliflozin Furanose Impurity
(R)-Cangliflozin Furanose Impurity is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: (2S,3R,4R,5S)-2-((R)-1,2-Dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol. Molecular formula: C24H25FO5S. Mole weight: 444.52.
(R)-CCG-1423
(R)-CCG-1423 is a stereoisomer of CCG-1423, a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). Synonyms: (R)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide. Grade: ≥98%. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.8.
(R)-CE3F4
(R)-CE3F4 is an Epac inhibitor (IC50 = 4.2 and 44 μM for Epac1 and Epac2(B), respectively), suppressing the activation of Epac by cAMP. Synonyms: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde. Grade: ≥98% by HPLC. CAS No. 1593478-56-8. Molecular formula: C11H10Br2FNO. Mole weight: 351.01.
(R)-Cetirizine diHCl (Levocetirizine diHCl)
(R)-Cetirizine diHCl (Levocetirizine diHCl) is a potent pharmaceutical compound employed within the biomedical sphere for studying allergic conditions like hay fever and urticaria. This compound is acting as a selective antagonist at the histamine H1 receptor, effectively mitigates the manifestation of symptoms attributable to an overabundance of histamine. Uses: Histamine h1 antagonists, non-sedating. Synonyms: (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride, Levocetirizine dihydrochloride. Grade: >98%. CAS No. 130018-87-0. Molecular formula: C21H27Cl3N2O3. Mole weight: 388.90 2 36.46.
(R)-Cetirizine N-Oxide DiHCl
an impurity of cetirizine. Synonyms: Acetic acid, 2-[2-[4-[(R)?-(4-chlorophenyl)?phenylmethyl]?-1-oxido-1-piperazinyl]?ethoxy]?-. Grade: > 95%. CAS No. 442863-80-1. Molecular formula: C21H25ClN2O4. Mole weight: 404.9.
(R)-cis-5ξ-Methyl Atracurium
An impurity of Cisatracurium besilate. Atracurium besilate is a non-depolarizing neuromuscular blocking drug (NMBD). Synonyms: 2,2'-[[(1RS)-1-methylpentane-1,5-diyl]bis[oxy(3-oxopropane-3,1-diyl)]]bis[(1R,2R)-1-[(3,4-dimethoxyphenyl)-methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]. CAS No. 1193104-81-2. Molecular formula: C54H74N2O12. Mole weight: 943.17.
(R,cis)-7-Methyl Atracurium dibesylate
(R,cis)-7-Methyl Atracurium dibesylate is an impurity of Cisatracurium, an enantiomer of a neuromuscular blocking agent. Synonyms: (1R,2R,1'R,2'R)-2,2'-{(3-Methyl-1,5-pentanediyl)bis[oxy(3-oxo-3,1-propanediyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] dimethanesulfonate; (1R,1'R,2R,2'R)-2,2'-(((3-Methylpentane-1,5-diyl)bis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium)Dibesylate. CAS No. 1193104-80-1. Molecular formula: C56H80N2O18S2. Mole weight: 1133.37.
(R)-Citalopram Oxalate
(R)-Citalopram Oxalate is an inhibitor of serotonin (5-HT) uptake. It shows antidepressant activity. Synonyms: 1-(3-Dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile Oxalate. Grade: > 95%. CAS No. 219861-53-7. Molecular formula: C22H23FN2O5. Mole weight: 414.43.
(R)-(-)-Clenbuterol
(R)-(-)-Clenbuterol is the (R)-Enantiomer of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4(PDE-IV) and production of tumor necrosis factor-α (TNF-α). Uses: (r)-enantiomer of clenbuterol. substituted phenylethanolamine with β2 sympathomimetic activity. bronchodilator. Synonyms: (αR)-4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol; (-)-Clenbuterol; (R)-Clenbuterol. Grade: 98%. CAS No. 50306-03-1. Molecular formula: C12H18Cl2N2O. Mole weight: 277.19.
(R)-(+)-Cotinine
(R)-(+)-Cotinine is the unnatural isomer of Cotinine, which is currently being used to treat depression, PTSD, schizophrenia, Alzheimer's disease and Parkinson's disease. Uses: The r metabolite of nicotine. this is the unnatural isomer of cotinine. carcinogen. Synonyms: (5R)-(+)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone; (+)-Cotinine; (R)-Cotinine; Ba 2701; (R)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one. Grade: ≥90%. CAS No. 32162-64-4. Molecular formula: C10H12N2O. Mole weight: 176.22.
(R)-CPP
(R)-CPP, a piperazine derivative, has been found to be an effective NMDA receptor antagonist. Synonyms: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid. Grade: ≥95% by HPLC. CAS No. 126453-07-4. Molecular formula: C8H17N2O5P. Mole weight: 252.21.
(R)-CR8
Molecular glue; brings about ubiquination and degradation of cyclin K. Synonyms: (R)-CR8; (R)-CR-8; (R)-CR 8; CR8; CR-8; CR 8; CR8 CDK inhibitor; CR8 CDK inhibitor HCl; CR8 CDK inhibitor hydrochloride; (R)-CR8 trihydrochloride. Grade: ≥99% (HPLC). CAS No. 1786438-30-9. Molecular formula: C24H29N7O.3HCl. Mole weight: 540.92.
(R)-Dapoxetine Hydrochloride
(R)-Dapoxetine Hydrochloride is a selective serotonin reuptake inhibitor (SSRI). Synonyms: (αR)-N,N-Dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-benzenemethanamine Hydrochloride. Grade: > 95%. CAS No. 156453-51-9. Molecular formula: C21H24ClNO. Mole weight: 341.87.
(R)-Darifenacin Hydrobromide
(R)-Darifenacin Hydrobromide is an impurity of Darifenacin, a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor. Synonyms: Darifenacin R Isomer; (3R)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetamide Hydrobromide; ent-Darifenacin Hydrobromide. CAS No. 1092800-15-1. Molecular formula: C28H31BrN2O2. Mole weight: 507.47.
(R)-Desethyl oxybutynin HCl
An impurity of Oxybutynin which reduces muscle spasms of the bladder and urinary tract. Synonyms: (R)-N-Desethyl Oxybutynin Hydrochloride; (αR)-α-Cyclohexyl-α-hydroxybenzeneacetic Acid 4-(Ethylamino)-2-butyn-1-yl Ester Hydrochloride. Grade: > 95%. CAS No. 181647-12-1. Molecular formula: C20H27NO3.HCl. Mole weight: 365.9.
(R)-Desmethyl Atomoxetine Hydrochloride
(R)-Desmethyl Atomoxetine Hydrochloride is a metabolite of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Synonyms: (R)-γ-(2-Methylphenoxy)benzenepropanamine Hydrochloride; Atomoxetine N-Desmethyl Impurity; (R)-3-(2-Methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1); Benzenepropanamine, γ-(2-methylphenoxy)-, (3R)-, hydrochloride (1:1). Molecular formula: C16H20ClNO. Mole weight: 277.79.
(R)-(+)-Desmethyl carvedilol
(R)-(+)-Desmethyl carvedilol is an optically active metabolite of Carvedilol, which is a medication used to treat high blood pressure, congestive heart failure (CHF), and left ventricular dysfunction in otherwise stable people. Synonyms: (R)-2-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenol; (R)-(+)-O-Desmethylcarvedilol; Phenol, 2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-, (R)-. Grade: 95%. CAS No. 123372-14-5. Molecular formula: C23H24N2O4. Mole weight: 392.45.
(R)-Desmethyl Citalopram-d4 Oxalate
(R)-Desmethyl Citalopram-d4 Oxalate is the labelled analogue of (S)-Citalopram Oxalate, which is an inhibitor of serotonin (5-HT) uptake, and an antidepressant agent. Grade: 98% HPLC. Molecular formula: C19H15FN2OD4·C2H2O4. Mole weight: 404.44.
(R)-Desmethyl Citalopram Hydrochloride
(R)-Desmethyl Citalopram Hydrochloride is an impurity of Citalopram, an antidepressant of the selective serotonin reuptake inhibitor class. Synonyms: (R)-(-)-N-Demethylcitalopram Hydrochloride. Grade: 95%. CAS No. 144010-85-5. Molecular formula: C19H20ClFN2O. Mole weight: 346.8.
(R)-Desmethyl Doxylamine
Desmethyl Doxylamine is an impurity of Doxylamine. Synonyms: N,N-Dimethyl-2-(phenyl-2-pyridinylmethoxy)ethanamine; 2-[α-[2-(Dimethylamino)ethoxy]benzyl]pyridine. Grade: > 95%. CAS No. 1221-70-1. Molecular formula: C16H20N2O. Mole weight: 256.34.
(R)-Desmethyl Rabeprazole
R enantiomer of Desmethyl Rabeprazole. Desmethyl Rabeprazole is a derivative of Rabeprazole. Rabeprazole is proton pump inhibitor as an antiulcer drug. Grade: > 95%. Molecular formula: C17H19N3O3S. Mole weight: 345.42.
(R)-Desmethyl Rabeprazole Sodium Salt
R enantiomer of Desmethyl Rabeprazole Sodium Salt. Desmethyl Rabeprazole Sodium Salt is a derivative of Rabeprazole. Rabeprazole is proton pump inhibitor as an antiulcer drug. Grade: > 95%. Molecular formula: C17H18N3O3S.Na. Mole weight: 367.41.
An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: (R)-Diethyl 4,4'-((2-(5-(2-fluoro-3-methoxy phenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)azanediyl)dibutanoate. Grade: 95%. CAS No. 2316733-81-8. Molecular formula: C40H44F5N3O7. Mole weight: 773.8.
(R)-Diphenylprolinol
(R)-Diphenylprolinol is the (R)-enantiomer of Diphenylprolinol, which is a norepinephrine-dopamine reuptake inhibitor used as a designer drug. Uses: (r)-(+)-diphenyl-2-pyrrolidinemethanol is used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones. Synonyms: R-(+)-Diphenylprolinol; (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine; (R)-(+)-Diphenyl-2-pyrrolidinemethanol; (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol; (R)-2-(Diphenylhydroxymethyl)pyrrolidine; (R)-Diphenyl(pyrrolidin-2-yl)methanol; (R)-α-(2-pyrrolidinyl)benzhydryl alcohol; 2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-. Grade: ≥95%. CAS No. 22348-32-9. Molecular formula: C17H19NO. Mole weight: 253.35.
(R)-DMT-glycidol-A(Bz)
(R)-DMT-glycidol-A(Bz) is a biochemical reagent extensively employed in the development of various types of antibiotics and anti-cancer drugs. It also shows potential application in the treatment of neurodegenerative illnesses. Synonyms: Benzamide, N-[9-[(2R)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-9H-purin-6-yl]-; N-(9-{(R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-9H-purin-6-yl)-benzamide. Grade: ≥95%. CAS No. 115233-93-7. Molecular formula: C36H33N5O5. Mole weight: 615.68.
(R)-DMT-glycidol-C(Bz)
(R)-DMT-glycidol-C(Bz) is a biomedical compound utilized in the syntheses of complex drug molecules. Its primary use is in the development of treatments for cardiovascular diseases, specifically aiding in anti-hypertension drug formulation. Synonyms: (R)-1-[3-(4,4'-Dimethoxytrityloxy)-2-hydroxypropyl]-N4-benzoylcytosine. Grade: ≥95%. CAS No. 2101315-01-7. Molecular formula: C35H33N3O6. Mole weight: 591.65.
(R)-DMT-glycidol-thymine
(R)-DMT-glycidol-thymine, a chemical amalgamation imbued with intriguing potentialities for the biomedical industry, has been meticulously scrutinized for its copious applications. In the veritable murkiness of viral infections, it has been postulated as a plausible antiviral agent, particularly against the herpes simplex virus. Furthermore, it exhibits consummate potential as a potential anti-cancer agent, specifically in tackling the vagaries of leukemia and breast cancer. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(2R)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-5-methyl-. Grade: ≥95%. CAS No. 168332-14-7. Molecular formula: C29H30N2O6. Mole weight: 502.56.
(R)-DPN
(R)-DPN has been found to be an estrogen receptor (ER) β agonist with higher affinity for estrogen receptor. Synonyms: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile. Grade: ≥98% by HPLC. CAS No. 524047-78-7. Molecular formula: C15H13NO2. Mole weight: 239.27.
(R)-DRF053 dihydrochloride
The hydrochloride salt form of (R)-DRF053, which is a cdk/CK1 inhibitor and could be used in studies in the cancer treatment with combinations of CDK kinase and ERK inhibitors. Synonyms: (R)-DRF053 dihydrochloride; (R)-DRF 053 dihydrochloride; (R)-DRF-053 dihydrochloride; 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1241675-76-2. Molecular formula: C23H27N7O.2HCl. Mole weight: 490.43.
(R)-Duloxetine
(R)-Duloxetine is the R-configuration of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: (γR)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine; (R)-N-Methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine; (3R)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine; 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γR)-; Duloxetine EP Impurity A; Duloxetine USP Related Compound A. Grade: 95%. CAS No. 116539-60-7. Molecular formula: C18H19NOS. Mole weight: 297.41.
(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(methoxy(methyl)carbamoyl)phenyl)propyl)thio)methyl)cyclopropyl)acetic Acid is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Molecular formula: C35H35ClN2O4S. Mole weight: 615.18.
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: (2E,4R)-5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoicacid; 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoicacid; 2-Pentenoicacid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]aminChemicalbooko]-2-methyl-, (2E,4R)-; (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid; SCHEMBL18765. Grade: 95%. CAS No. 1012341-48-8. Molecular formula: C23H27NO4. Mole weight: 381.46.
(R)-Edelfosine
(R)-Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. It induces apoptosis in human promyelocytic HL-60 leukemic cells and promonocytic U937 leukemic cells. Synonyms: 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide, (7R)-; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-; 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine; ET 18-OCH3; TLC ELL 12; (R)-2-methoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate; (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide. Grade: >99%. CAS No. 77286-66-9. Molecular formula: C27H58NO6P. Mole weight: 523.73.
(rel)-AR234960
(rel)-AR234960 is an active relative configuration of AR234960, a non-peptide MAS (a G protein-coupled receptor) agonist that increases mRNA and protein levels of CTGF in HEK293-MAS cells and adult cardiac fibroblasts via the ERK1/2 signaling pathway. Synonyms: 1-({(3R,4R)-4-(3-Fluorophenyl)-1-[(2-methoxy-4-nitrophenyl)sulfonyl]-3-pyrrolidinyl}methyl)-4-(2-pyridinyl)piperazine; Piperazine, 1-[[(3R,4R)-4-(3-fluorophenyl)-1-[(2-methoxy-4-nitrophenyl)sulfonyl]-3-pyrrolidinyl]methyl]-4-(2-pyridinyl)-. Grade: ≥95%. CAS No. 1408311-94-3. Molecular formula: C27H30FN5O5S. Mole weight: 555.62.
(R)-Emtricitabine Sulfoxide
An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) used in the treatment and prevention of HIV-1 infection. Synonyms: Emtricitabine (R)-sulphoxide; Emtricitabine Sulfoxide Impurity Isomer-2 (R-isomer); Emtricitabine Impurity 17; 4-Amino-5-fluoro-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; (R)-Emtricitabine S-oxide; (R)-Emtricitabine 3'-oxide; (R)-Emtricitabine-3'-sulfoxide; Emtricitabine Sulfoxide Isomer 2. Grade: ≥95%. CAS No. 2101981-64-8. Molecular formula: C8H10FN3O4S. Mole weight: 263.24.
(R)-Encorafenib
Encorafenib is a Proto oncogene protein b raf inhibitor with potential antineoplastic activity. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of Encorafenib may result in a decrease in proliferation of tumor cells. Now, treatment for Colorectal cancer and Malignant melanoma is in clinical trials Phase III. Treatment for Multiple myeloma and Solid tumours is in clinical trials Phase II. Uses: Colorectal cancer; malignant melanoma;multiple myeloma; solid tumours. Synonyms: LGX818; LGX 818; LGX-818; UNII-8L7891MRB6; methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate; 1269440-29-0 (R-isomer of LGX-818). Grade: 98%. CAS No. 1269440-29-0. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.01.
(R)-Equol
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. Synonyms: (+)-Equol; Isoequol; (3R)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol. Grade: ≥98%. CAS No. 221054-79-1. Molecular formula: C15H14O3. Mole weight: 242.27.
(R)-Esmolol Acid
(R)-Esmolol Acid is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Uses: The r-enantiomer metabolite of esmolol (e668000) in humans. Synonyms: 4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic Acid. CAS No. 910651-37-5. Molecular formula: C15H23NO4. Mole weight: 281.35.
(R)-Esmolol Hydrochloride
(R)-Esmolol Hydrochloride is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Uses: The r-enantiomer of esmolol (e668000). Synonyms: 4-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic Acid Methyl Ester Hydrochloride; (+)-Esmolol Hydrochloride. Grade: >95%. CAS No. 118629-36-0. Molecular formula: C16H25NO4.HCl. Mole weight: 331.83.
(R)-ethyl 4-cyano-3-hydroxybutanoate
(R)-ethyl 4-cyano-3-hydroxybutanoate is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester; (R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester; Ethyl (R)-4-Cyano-3-hydroxybutanoate. CAS No. 141942-85-0. Molecular formula: C7H11NO3. Mole weight: 157.17.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-59-1. Molecular formula: C25H31NO4. Mole weight: 409.526.
(R)-Ezetimibe
A stereoisomer of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L9) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: R,R,S-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3'R)-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; (3'R)-SCH 58235; 3'R,3R,4S-Isomer of Ezetimibe; Ezetimibe (3R,4S,3'R)-Isomer; Ezetimibe (3R)-Isomer; (3R,4S,3'R)-Ezetimibe. Grade: >95%. CAS No. 163380-16-3. Molecular formula: C24H21F2NO3. Mole weight: 409.44.
(R)-Ezetimibe Desfluoro Chloro Impurity
An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L47) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(4-chlorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H21ClFNO3. Mole weight: 425.89.
(R)-Fesoterodine Fumarate
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. Synonyms: SPM 907; SPM907; SPM-907. Grade: >98%. CAS No. 286930-03-8. Molecular formula: C26H37NO3.C4H4O4. Mole weight: 527.65.