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Gramicidin
It is produced by the strain of Bacillus brevis. It is a family of linear pentadecapeptides isolated from bacillus brevis, and it is a complex of six closely related analogues A1, A2, B1, B2, C1 and C2 where A1 and A2 are the dominant components. It acts by forming channels in cell membranes causing ion leakage, and is an essential bioprobe for understanding the nature of the cell membranes. Synonyms: Gramicidina; Gramicidinum; garamicidin D; HCO-Val-Gly-D-Leu-Ala-D-Val-Val-D-Val-[Trp-D-Leu]3-Trp-NH2-CH2CH2OH. Grades: >95% by HPLC. CAS No. 1405-97-6. Molecular formula: C99H140N20O17. Mole weight: 1882.29.
Gramicidin S dihydrochloride
It is produced by the strain of Bacillus brevis. It mainly has anti-gram-positive bacterial activity. Synonyms: Gramicidin S 2HCl. CAS No. 15207-30-4. Molecular formula: C60H92N12O10.2HCl. Mole weight: 1214.36.
Granaticin B
It is produced by the strain of Streptomyces olvaceus var. ETH 7437, Str. violaceoruber. It inhibits the initial stage of RNA biosynthesis, has anti-gram-positive bacteria, Mycobacterium (weak) and vaginal trichomonas activity, but also can inhibit tumor cells. CAS No. 19879-03-9. Molecular formula: C28H30O12. Mole weight: 558.53.
Granaticinic acid
It is produced by the strain of Streptomyces sp. XT-11989. It's a quinone antibiotic. It has anti-gram-positive bacterial activity. Synonyms: (1R,13R)-1,3,4,6,7,9,10,11-Octahydro-4α,5,10β,12,13-pentahydroxy-3α,7α-dimethyl-6,11-dioxo-1β,4-ethanonaphtho[2,3-c:6,7-c']dipyran-9β-acetic acid; 10-Hydroxygranatomycin D; Granatomycin E. CAS No. 71203-17-3. Molecular formula: C22H22O11. Mole weight: 462.40.
Granatomycin B
It is produced by the strain of Streptomyces lateritius (ZIMET 43646). It's a quinone antibiotic. It has anti-gram positive bacteria and negative bacteria activity. Synonyms: Granaticin methyl ester; (1R,13R)-1,3,4,6,7,9,10,11-Octahydro-4α,5,10β,12,13-pentahydroxy-3α,7α-dimethyl-6,11-dioxo-1β,4-ethanonaphtho[2,3-c:6,7-c']dipyran-9β-acetic acid methyl ester; (1R,13R)-3,4,9,10-Tetrahydro-4α,5,10β,12,13-pentahydroxy-9β-(methoxycarbonylmethyl)-3α,7α-dimethyl-1β,4-ethanonaphtho[2,3-c:6,7-c']dipyran-6,11(1H,7H)-dione; 10-Hydroxygranatomycin methyl ester; Methylgranaticin. CAS No. 71203-18-4. Molecular formula: C23H24O11. Mole weight: 476.43.
Graphislactone A
It is the major analogue of a family of phenolic benzopyranones isolated from a mycobiont of lichens of the genus graphis. It protects against oxidative injury by dose-dependent free radical scavenging and antioxidant activity. Synonyms: Graphislactone S1; 6H-Dibenzo[b,d]pyran-6-one, 4,7-dihydroxy-3,9-dimethoxy-1-methyl-. Grades: >95% by HPLC. CAS No. 52179-44-9. Molecular formula: C16H14O6. Mole weight: 302.28.
GRGDSPC
GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide. Synonyms: H-Gly-Arg-Gly-Asp-Ser-Pro-Cys-OH; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-cysteine; (S)-3-(2-((S)-2-(2-aminoacetamido)-5-guanidinopentanamido)acetamido)-4-((S)-1-((S)-2-((R)-1-carboxy-2-mercaptoethylcarbamoyl)pyrrolidin-1-yl)-3-hydroxy-1-oxopropan-2-ylamino)-4-oxobutanoic acid. Grades: 95%. CAS No. 91575-26-7. Molecular formula: C25H42N10O11S. Mole weight: 690.73.
Griseolic acid A
It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.16 X 10-6 mol/L (Extracted from rat brain). Griseolic acid A can stimulate the flow of glycogen and increase the blood sugar level in mice. Synonyms: griseolic acid; 1-(6-Amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5-dideoxy-α-L-talo-4-octenofuranuronic acid. CAS No. 79030-08-3. Molecular formula: C14H13N5O8. Mole weight: 379.28.
Griseolic acid B
It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.16 X 10-6 mol/L (Extracted from rat brain). Synonyms: (2R,5R,6R,6aS)-5-(6-amino-9H-purin-9-yl)-2-(carboxymethyl)-6-hydroxy-2,5,6,6a-tetrahydrofuro[3,2-b]furan-2-carboxylic acid; Deoxygriseolic Acid; 1-(6-Amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy-β-D-ribo-4-octenofuranuronic acid; 7'-Desoxygriseolic acid. CAS No. 98890-01-8. Molecular formula: C14H13N5O7. Mole weight: 363.28.
Griseolic acid C
It is produced by the strain of Streptomyces griseoaurantiacus SANK43894. It has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with IC50 0.12 X 10-6 mol/L (Extracted from rat brain). Synonyms: (3aR,5R,6R,6aS)-5-(6-amino-9H-purin-9-yl)-2-(carboxymethyl)-6-hydroxyhexahydrofuro[3,2-b]furan-2-carboxylic acid; beta-D-allo-Octofuranuronic acid, 1-(6-amino-9H-purin-9-yl)-3,6-anhydro-6-C-carboxy-1,5,7-trideoxy-. CAS No. 100242-49-7. Molecular formula: C14H15N5O7. Mole weight: 365.30.
Griseolutein A
It is produced by the strain of Streptomyces griseoluteus. Griseolutein A and Griseolutein B have similar activitiy against gram-positive and negative bacteria. Synonyms: 6-(((Hydroxyacetyl)oxy)methyl)-9-methoxy-1-phenazinecarboxylic acid; 1-Phenazinecarboxylic acid, 6-(hydroxymethyl)-9-methoxy-, glycolate (ester). Grades: >98%. CAS No. 573-84-2. Molecular formula: C17H14N2O6. Mole weight: 342.30.
Griseolutein B
It is produced by the strain of Streptomyces griseoluteus. Griseolutein A and Griseolutein B have similar activitiy against gram-positive and negative bacteria, and Griseolutein B also inhibits rickettsia, trichomonas vaginalis and Ehrlichite ascites cancer. Synonyms: 6-[(1,2-Dihydroxyethoxy)methyl]-9-methoxy-1-phenazinecarboxylic acid. Grades: >98%. CAS No. 2072-68-6. Molecular formula: C17H16N2O6. Mole weight: 344.32.
Griseorhodin A
It is produced by the strain of Streptomyces californicus JA-2640 and Str. griseus (FCRC-57). It is a quinone antibiotic. It mainly has anti-gram-positive bacterial activity. Synonyms: 1'a,9'b-Dihydro-3,4,4',9-tetrahydroxy-7-methoxy-7'-methylspiro[naphtho[2,3-b]furan-2(3H),2'(5'H)-oxireno[d]benzo[1,2-b:5,4-c']dipyran]-5,5',8-trione. Grades: 99%. CAS No. 11048-91-2. Molecular formula: C25H16O12. Mole weight: 508.39.
Griseorhodin C
It is produced by the strain of Streptomyces californicus JA-2640 and Str. griseus (FCRC-57). It is a quinone antibiotic. It mainly has anti-gram-positive bacteria and negative bacteria (individual) activity. Molecular formula: C25H18O13. Mole weight: 526.40.
Griseorhodin G
It is produced by the strain of Streptomyces californicus JA-2640 and Str. griseus (FCRC-57). It is a quinone antibiotic. It has antitumor activity. Synonyms: NSC289645; FCRC57-G; FCRC-57-G. Molecular formula: C25H18O12. Mole weight: 510.40.
Griseusin A
It is produced by the strain of Streptomyces griseus. It is a quinone antibiotic. It mainly has anti-gram-positive bacterial activity. Synonyms: (-)-Griseusin A; (3aR,5R)-3'alpha,7-Dihydroxy-4'alpha-acetoxy-6'beta-methyl-3',3aalpha,4',5',6',11balpha-hexahydrospiro[2H-furo[3,2-b]naphtho[2,3-d]pyran-5(3H),2'-[2H]pyran]-2,6,11-trione; (5R,3aR,11bR)-4'α-Acetyloxy-3',3a,4',5',6',11b-hexahydro-3'α,7-dihydroxy-6'β-methylspiro[5H-furo[3,2-b]naphtho[2,3-d]pyran-5,2'-[2H]pyran]-2,6,11(3H)-trione. CAS No. 59554-11-9. Molecular formula: C22H20O10. Mole weight: 444.39.
Griseusin B
It is produced by the strain of Streptomyces griseus. It is a quinone antibiotic. It mainly has anti-gram-positive bacterial activity. Synonyms: [(1R,3S,3'S,4'R,6'R)-4'-acetoxy-3',9-dihydroxy-6'-methyl-5,10-dioxo-3,3',4,4',5,5',6',10-octahydrospiro[naphtho[2,3-c]pyran-1,2'-pyran]-3-yl]acetic acid; (1R)-4'α-Acetoxy-3,3',4,4',5,5',6',10-octahydro-3'α,9-dihydroxy-6'β-methyl-5,10-dioxospiro[1H-naphtho[2,3-c]pyran-1,2'-[2H]pyran]-3α-acetic acid. CAS No. 59554-12-0. Molecular formula: C22H22O10. Mole weight: 446.40.
Growth Hormone, Human
Human growth hormone is a single-chain polypeptide hormone required for the growth of tissues. Synonyms: cb311; crecormon; humatrope; ly137998; norditropin; sj0011; OVINE SOMATOTROPIN; SOMATOTROPIN. Grades: 95%. CAS No. 12629-01-5. Molecular formula: C990H1529N263O299S7. Mole weight: 22124.12.
GTRI-BB
GTRI-BB is from Micromonospora sp. SA-246 with anti-gram-positive bacteria activity and cytotoxicity. The GI50 (μg/mL) of PC-3 (prostate), A549 (lung) and K562 (leukemia) cells were 0.21, 0.25 and 0.21 respectively. Molecular formula: C33H26O13. Mole weight: 630.55.
Guamecycline dihydrochloride
It is produced by the strain of Streptomyces sp. NK11687. It is a semisynthetic tetracycline. The antibacterial spectrum and antibacterial activity are the same as tetracycline, it is characterized by stronger affinity to bronchial and lung tissue than tetracycline, blood drug concentration is higher than tetracycline and lasting. Synonyms: guamecycline dihydrochloride; Xanthomycin a, dihydrochloride; Xanthocycline dihydrochloride; Guamecycline 2HCl; 2-Naphthacenecarboxamide, N- ( (4- ( ( (aminoiminomethyl)amino)iminomethyl)-1-piperazinyl)methyl)-4- (dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-, dihydrochloride, (4S-(4alpha, 4aalpha, 5aalpha, 6beta, 12aalpha))-. Grades: ≥95%. CAS No. 13040-98-7. Molecular formula: C29H38N8O8.2HCl. Mole weight: 699.59.
Guanidylfungin A
It is produced by the strain of Streptomyces hygroscopicus 662. It is a macrolide antibiotic. It has weak anti-gram-negative bacterial and fungal activity. CAS No. 94116-22-0. Molecular formula: C58H103N3O18. Mole weight: 1130.45.
Guanidylfungin B
It is produced by the strain of Streptomyces hygroscopicus 662. It is a macrolide antibiotic. It has weak anti-gram-negative bacterial and fungal activity. Synonyms: Guanidylfungin A, N-demethyl-, (9alpha,11alpha,13E,15S)-. CAS No. 94116-20-8. Molecular formula: C57H101N3O18. Mole weight: 1116.42.
Guanine-7-oxide hydrochloride
Guanine-7-oxide hydrochloride is produced by the strain of Streptomyces sp. It has anti-tumor, anti-candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. It has good activity against mouse L1210 leukemia cells. Synonyms: 7-Hydroxyguanine hydrochloride; Guanine 7-N-oxide hydrochloride. Molecular formula: C5H5N5O2.HCl. Mole weight: 203.59.
Guanylin (human)
Guanylin (human) secreted by the gastrointestinal mucosa is an endogenous peptide activator of intestinal guanylyl cyclase. It modulates water and electrolyte transport in intestinal and renal epithelia. Synonyms: L-prolyl-glycyl-L-threonyl-L-cysteinyl-L-alpha-glutamyl-L-isoleucyl-L-cysteinyl-L-alanyl-L-tyrosyl-L-alanyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteine (4->12),(7->15)-bis(disulfide); H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bridge: Cys4-Cys12, Cys7-Cys15). Grades: ≥95%. CAS No. 183200-12-6. Molecular formula: C58H87N15O21S4. Mole weight: 1458.65.
Gunacin
It is produced by the strain of Ustilago sp. It is a quinone antibiotic. It has strong activity against gram-positive bacteria, negative bacteria and mycoplasma. Synonyms: 2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4-dihydro-4-(acetyloxy)-3,6-dihydroxy-8-methoxy-2-methyl-. Grades: 95%. CAS No. 73341-70-5. Molecular formula: C17H16O8. Mole weight: 348.33.
Gypsetin
It is produced by the strain of Nannizzia gypsea var. incurvata IFO 9228. It can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with IC50 of 18 μmol/L, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μmol/L. It also inhibits [14C] oleic acid from forming cholesterol esters with IC50 of 0.65 μmol/L. Synonyms: Gypsetine; (-)-Gypsetin; 8a, 16a-Dihydroxy-5a, 13a-bis (1, 1-dimethylallyl)- (1)-benzazolidine- (3''', 2''': 4'', 5'')azolidino- (1'', 2'': 4', 5') (1, 4)perhydrodiazin- (1', 2': 1, 5)azolidino- (2, 3-b)- (1)-benzazolidine-7, 15-dione; Pyrazino(1'', 2'':1, 5;4'', 5'':1', 5')dipyrrolo(2, 3-b:2', 3'-b')diindole-7, 15(5H, 7aH)-dione, 5a, 13a-bis(1, 1-dimethyl-2-propenyl)-5a, 8, 8a, 13, 13a, 15a, 16, 16a-octahydro-8a, 16a-dihydroxy-, (5aalpha, 7aalpha, 8abeta, 13abeta, 15aalpha, 16aalpha)-. CAS No. 155114-38-8. Molecular formula: C32H36N4O4. Mole weight: 540.66.
It is produced by the strain of Nectria haematococca Berk. et Br. (880701a-1). It can inhibit the germination of Pyricularia oryzae spore. 500 μg/mL of Haematocin culture 5h may inhibit 97.5% spore germination, but has no effect below 30 μg/mL. Synonyms: 6H,13H-pyrazino[1,2-a,4,5-a']diindole-6,13-dione,4,11-bis(acetyloxy)-4,4a,6a,7,11,11a,13a,14-octahydro-6a,13a-bis(methylthio)-,(4S,4aS,6aS,11S,11aS,13aR)-(9Cl). CAS No. 262425-39-8. Molecular formula: C24H26N2O6S2. Mole weight: 502.60.
It is produced by the strain of Haliangium luteum AJ-13395, H. ochraceum. It is similar to amphotericin B with anti-filamentous fungi activity (MIC 0.1-12.5 μg/mL), and it also has effect on oomycetes, but has no antibacterial activity. The antifungal activity of cis-trans isomer is similar, the activity of Haliangicin B and C is weaker than Haliangicin A, and the activity of Haliangicin D is weakest. Synonyms: Haliangicin. Molecular formula: C22H32O5. Mole weight: 376.49.
Haliangicin B
It is produced by the strain of Haliangium luteum AJ-13395, H. ochraceum. It is similar to amphotericin B with anti-filamentous fungi activity (MIC 0.1-12.5 μg/mL), and it also has effect on oomycetes, but has no antibacterial activity. The antifungal activity of cis-trans isomer is similar, the activity of Haliangicin B and C is weaker than Haliangicin A, and the activity of Haliangicin D is weakest. Molecular formula: C22H32O5. Mole weight: 376.49.
Haliangicin C
It is produced by the strain of Haliangium luteum AJ-13395, H. ochraceum. It is similar to amphotericin B with anti-filamentous fungi activity (MIC 0.1-12.5 μg/mL), and it also has effect on oomycetes, but has no antibacterial activity. The antifungal activity of cis-trans isomer is similar, the activity of Haliangicin B and C is weaker than Haliangicin A, and the activity of Haliangicin D is weakest. Molecular formula: C22H32O5. Mole weight: 376.49.
Haliangicin D
It is produced by the strain of Haliangium luteum AJ-13395, H. ochraceum. It is similar to amphotericin B with anti-filamentous fungi activity (MIC 0.1-12.5 μg/mL), and it also has effect on oomycetes, but has no antibacterial activity. The antifungal activity of cis-trans isomer is similar, the activity of Haliangicin B and C is weaker than Haliangicin A, and the activity of Haliangicin D is weakest. Molecular formula: C22H32O5. Mole weight: 376.49.
H-Allyl-D-glycine
. Uses: A new chiral glycine equivalent; used for the preparation of enantiomerically pure α-tertiary and α-quaternary α-amino acids. a bacillus spore germination alanine analog. Synonyms: D-Gly(allyl)-OH; (R)-2-Amino-4-pentenoic acid. Grades: ≥ 98% (HPLC). CAS No. 54594-06-8. Molecular formula: C5H9NO2. Mole weight: 115.14.
Halomicin A
It is produced by the strain of Micromonospora halophytica var. nigra. It's an ansamycin antibiotic. Halomicin complex has activity against gram-positive and gram-negative bacteria (individual). Synonyms: SP-30-A; 4-Deoxy-4-[3-hydroxy-2-(1-hydroxyethyl)-1-pyrrolidinyl]rifamycin; Rifamycin, 4-deoxy-4-(3-hydroxy-2-(1-hydroxyethyl)-1-pyrrolidinyl)-. CAS No. 56411-51-9. Molecular formula: C43H58N2O13. Mole weight: 810.93.
Halomicin B
It is produced by the strain of Micromonospora halophytica var. nigra. It's an ansamycin antibiotic. Halomicin complex has activity against gram-positive and gram-negative bacteria (individual). Synonyms: Rifamycin, 4-deoxy-4-(2-(1-hydroxyethyl)-1-pyrrolidinyl)-, (4(2R(1S)))-. CAS No. 54356-09-1. Molecular formula: C43H58N2O12. Mole weight: 794.92.
Halomicin C
It is produced by the strain of Micromonospora halophytica var. nigra. It's an ansamycin antibiotic. Halomicin complex has activity against gram-positive and gram-negative bacteria (individual). Synonyms: 4-Deoxy-20-hydroxy-4-[2-(1-hydroxyethyl)-1-pyrrolidinyl]rifamycin. CAS No. 64419-06-3. Molecular formula: C43H58N2O13. Mole weight: 810.93.
Halomicin D
It is produced by the strain of Micromonospora halophytica var. nigra. It's an ansamycin antibiotic. Halomicin complex has activity against gram-positive and gram-negative bacteria (individual). Synonyms: N,2-Didehydro-1,4-dideoxy-1,2-dihydro-4-[(2R)-2-[(S)-1-hydroxyethyl]-1-pyrrolidinyl]-1-oxorifamycin. CAS No. 56413-94-6. Molecular formula: C43H56N2O12. Mole weight: 792.91.
Haloquinone
It is produced by the strain of Streptomyces venezuelae subsp. xanthophaeus Tu 2115. It is a quinone antibiotic. It has strong anti-bacterial activity on Halobacteria, and also has effects on gram-positive bacteria and mycoplasma. Synonyms: 3-Acetyl-1,8-dihydroxy-2-methyl-9,10-phenanthrenequinone; 9,10-Phenanthrenedione, 3-acetyl-1,8-dihydroxy-2-methyl-. CAS No. 80902-01-8. Molecular formula: C17H12O5. Mole weight: 296.27.
H-α-Me-L-Trp-OH
. Uses: A therapeutic and carrier molecule. Synonyms: H-aMeTrp-OH; alpha-Methyl-L-tryptophan; alpha-Methyltryptophan. CAS No. 16709-25-4. Molecular formula: C12H14N2O2. Mole weight: 218.25.
Halymecin A
It is produced by the strain of Fusarium sp. FE-71-1. It's an antibiotic produced by Marine microbes. Halymecin A had only weak antibacterial and fungal activity. Grades: 95%. CAS No. 165561-10-4. Molecular formula: C42H76O14. Mole weight: 805.04.
HA Peptide
HA Peptide, derived from an epitope of the influenza hemagglutinin protein, is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry. Synonyms: Influenza Hemagglutinin (HA) Peptide; H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-OH; L-tyrosyl-L-prolyl-L-tyrosyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-alpha-aspartyl-L-tyrosyl-L-alanine. Grades: ≥97% by HPLC. CAS No. 92000-76-5. Molecular formula: C53H67N9O17. Mole weight: 1102.1.
It is produced by the strain of Pestalotiopsis theae. It can inhibit the formation of Sea urchin eggs Spindle. Synonyms: (4S,5R,6R)-2-(3-Methyl-3-Butene-1-Ynyl)-4-Hydroxy-5,6-Epoxy-2-Cyclohexene-1-One; (+)-Harveynone; (+)-PT-toxin; 5β,6β-Epoxy-4α-hydroxy-2-(3-methyl-3-buten-1-ynyl)-2-cyclohexen-1-one; (4R)-4β-Hydroxy-5α,6α-epoxy-2-(3-methylbutane-1-yne-3-ene-1-yl)-2-cyclohexene-1-one. CAS No. 142435-66-3. Molecular formula: C11H10O3. Mole weight: 190.19.
(-)-Harveynone
It is produced by the strain of Curvularia harveyi. It can inhibit the formation of Sea urchin eggs Spindle. Synonyms: (-)-Harveynone; (-)-PT-toxin; (4R,5S,6S)-2-(3-Methyl-3-Butene-1-Ynyl)-4-Hydroxy-5,6-Epoxy-2-Cyclohexene-1-One. CAS No. 125555-67-1. Molecular formula: C11H10O3. Mole weight: 190.19.
Harzialactone A
It is produced by the strain of Trichoderma harzianum OUPS-N115. Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED50 of > 100 μg/mL. Synonyms: (3S,5S)-5-benzyl-3-hydroxydihydrofuran-2(3H)-one; 3-hydroxy-5-phenylmethyl-(3S,5S)-tetrahydrofuran-2-one; (-)-harzialactone A; (-)-(2S,4S)-harzialactone A. CAS No. 321868-49-9. Molecular formula: C11H12O3. Mole weight: 192.21.
Harzialactone B
It is produced by the strain of Trichoderma harzianum OUPS-N115. Harzialacton B has weak cytotoxicity to P388 leukemia cells with ED50 of 60 μg/mL. Synonyms: (4R)-4-Hydroxy-4-vinyltétrahydro-2H-pyran-2-one; 2H-Pyran-2-one, 4-ethenyltetrahydro-4-hydroxy-, (4R)-; (R)-4-hydroxy-4-vinyltetrahydro-2H-pyran-2-one. Molecular formula: C7H10O3. Mole weight: 142.15.
Harzianic acid
It is produced by the strain of Trichoderma harzianum SY-307. It has the activity against Pasteurella Piscicida SP.6395. Synonyms: 2-Pyrrolidinepropanoic acid, 3,5-dioxo-alpha-hydroxy-4-(1-hydroxy-2,4-octadienylidene)-1-methyl-alpha-(1-methylethyl)-. Grades: ≥98%. CAS No. 157148-06-6. Molecular formula: C19H27NO6. Mole weight: 365.42.
Harzianopyridone
Harzianopyridone is a metabolite of Trichoderma harzianum that exhibits antifungal and antibacterial properties. Harzianopyridone acts as an atpenin-like inhibitor of mammalian and nematode mitochondrial complex II (succinate:ubiquinone oxidoreductase; SQR) with IC50 values of 0.017, 0.2, and 2 μM for bovine, rat, and nematode complex II, respectively. It also inhibits nematode quinol-fumarate reductase (QFR; IC50 = 0.36 μM). Synonyms: (-)-Harzianopyridone; 4-Hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexenyl]-2(1H)-pyridinone; 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-; 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexenyl]-; 4-Hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-2(1H)-pyridinone; (S,E)-4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)pyridin-2(1H)-one. Grades: ≥95%. CAS No. 137813-88-8. Molecular formula: C14H19NO5. Mole weight: 281.30.
Harzianum A
Harzianum A is a metabolite isolated from Trichoderma harzianum that exhibits antifungal properties. It is cytotoxic to human cancer cell lines. Synonyms: (4beta)-12,13-Epoxy-trichothec-9-en-4-ol 4-[hydrogen (2Z,4E,6E)-2,4,6-octatrienedioate]; Trichothec-9-en-4-ol, 12,13-epoxy-, 4-[hydrogen (2Z,4E,6E)-2,4,6-octatrienedioate], (4β)-; (4β)-4-[hydrogen (2Z,4E,6E)-2,4,6-octatrienedioate]12,13-epoxy-trichothec-9-en-4-ol. Grades: ≥95%. CAS No. 156250-74-7. Molecular formula: C23H28O6. Mole weight: 400.46.
Harziphilone
It is produced by the strain of Trichoderma harzianum. It has weak anti-gram-positive bacterial activity and anti-tumor effect, it can inhibit lymphoblastic leukemia L1210 and leukemia P388 with IC50 of 0.26 μg/mL. It inhibits the binding of viral particle regulatory (REV) proteins to [33P] labeled viral particle regulatory effector element (RRE) RNA, IC50 is 2.0 μmol/L. 200 μg/mL of Harziphilone does not protect CEM-SS cells from HIV-1 infection, and 38μmol/L of Harziphilone has cytotoxicity to mouse tumor cells M-109. Synonyms: rel-(6R,7R)-6,7-dihydroxy-7-methyl-3-[(1E,3E)-penta-1,3-dien-1-yl]-1,5,6,7-tetrahydro-8H-isochromen-8-one; (+)-Harziphilone; 8H-2-Benzopyran-8-one,1,5,6,7-tetrahydro-6,7-dihydroxy-7-methyl-3-(1E,3E)-1,3-pentadienyl-, (6R,7R)-rel-. CAS No. 183239-75-0. Molecular formula: C15H18O4. Mole weight: 262.30.
It is produced by the strain of Saccharopolyspora YL-0358M. It is an alkaloid antibiotic. It has weaker activity against gram-positive bacteria. It also shows cytotoxicity to lymphocytic leukemia L1210 and leukemia P388 cells. Synonyms: Antibiotic YL-0358M-A. CAS No. 116290-93-8. Molecular formula: C22H31NO5. Mole weight: 389.49.
Hatomarubigin A
It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-1,7,12(2H)-trione,3,4-dihydro-6-hydroxy-8-methoxy-3-methyl-, (S)-. CAS No. 139562-86-0. Molecular formula: C20H16O5. Mole weight: 336.34.
Hatomarubigin B
It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-1,7,12(2H)-trione,3,4-dihydro-11-hydroxy-8-methoxy-3-methyl-, (S)-. CAS No. 139501-91-0. Molecular formula: C20H16O5. Mole weight: 336.34.
Hatomarubigin C
It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-7,12-dione,1,2,3,4-tetrahydro-1,11-dihydroxy-8-methoxy-3-methyl-, (1S-cis)-; (1S)-1β,11-Dihydroxy-3β-methyl-8-methoxy-1,2,3,4-tetrahydrobenz[a]anthracene-7,12-dione. CAS No. 139501-92-1. Molecular formula: C20H18O5. Mole weight: 338.35.
Hatomarubigin D
It is produced by the strain of Streptomyces sp. 2238-SVT4. It can enhance the effect of Colchicines against multidrug resistance (MDR) tumor cells. Synonyms: Benz(a)anthracene-7,12-dione,10,10'-methylenebis(1,2,3,4-tetrahydro-1,11-dihydroxy-8-methoxy-3-methyl-, (1S-(1alpha,3alpha,10(1'R*,3'R*)))-. CAS No. 139501-93-2. Molecular formula: C41H36O10. Mole weight: 688.72.
Hazimycin factor 5
It is produced by the strain of Pseudomonas sp. SCC 1411 or Micromonospora echinospora var challisensis SCC 1411. It has weak activity against gram-negative bacteria, yeast and skin fungi. Synonyms: (±)-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; (RS,RS)-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; (αR,α'R)-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; (2R,2'R)-3,3'-(6,6'-dihydroxy-[1,1'-biphenyl]-3,3'-diyl)bis(2-cyanopropanamide). CAS No. 84894-71-3. Molecular formula: C20H18N4O4. Mole weight: 378.38.
Hazimycin factor 6
It is produced by the strain of Pseudomonas sp. SCC 1411 or Micromonospora echinospora var challisensis SCC 1411. It has weak activity against gram-negative bacteria, yeast and skin fungi. Synonyms: meso-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; (RS,SR)-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; Hazimicin factor 6; (αR,α'S)-6,6'-Dihydroxy-α,α'-diisocyano[1,1'-biphenyl]-3,3'-dipropionamide; (S)-3-(5'-((R)-3-amino-2-cyano-3-oxopropyl)-2',6-dihydroxy-[1,1'-biphenyl]-3-yl)-2-cyanopropanamide. CAS No. 84885-57-4. Molecular formula: C20H18N4O4. Mole weight: 378.38.