BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
It is produced by the strain of Pseudomonas pyocyanea, P. aeruginosa, P. methanica. HQNO is a quinolone inhibitor that blocks NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR). It has weak anti-gram-positive bacterial activity. It can inhibit the microsomal respiratory chain and 5-lipoxygenase of cytochrome BC1 complex, and antagonize the antibacterial activity of dihydrostreptomycin. Synonyms: Antibiotic KF 8940; 2-Heptyl-1-hydroxy-4-(1H)-quinolinone; 2-heptyl-4-hydroxyquinoline n-oxide; HOQNO; 2-Heptyl-4-quinolinol 1-oxide; 2-heptylquinolin-4-ol 1-oxide; 2-(n-Heptyl)-4-hydroxyquinoline N-oxide. Grades: ≥98%. CAS No. 341-88-8. Molecular formula: C16H21NO2. Mole weight: 259.34.
(S)-β-Phenylalanine is a key building block used as an intermediate in the synthesis of pharmaceuticals. Synonyms: (S)-3-Amino-3-phenylpropionic acid; Benzenepropanoic acid, β-amino-, (S)-; L-β-Phe-OH. Grades: ≥ 99% (HPLC). CAS No. 40856-44-8. Molecular formula: C9H11NO2. Mole weight: 165.19.
Synonyms: L-seryl-L-serine; Ser-Ser; Ser Ser. CAS No. 6620-95-7. Molecular formula: C6H12N2O5. Mole weight: 192.17.
HT-2 toxin
HT-2 toxin is a mycotoxin produced by Fusarium sp. Symptoms of poisoning are nausea, vomiting, diarrhea, and leukopenia. The acute toxicity is lower than trichothecene. Uses: This product is used as a reference standard in quantitative analysis of food stuffs. Synonyms: Mycotoxin HT 2; Toxin HT 2. CAS No. 26934-87-2. Molecular formula: C22H32O8. Mole weight: 424.48.
Human Histatin 8 is an antibacterial peptide isolated from Homo sapiens. It shows antibacterial and antifungal activity. Synonyms: Histatin-8; H-Lys-Phe-D-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH. Grades: 95.7%. CAS No. 127637-03-0. Molecular formula: C70H99N25O17. Mole weight: 1562.7.
Humanin
Synonyms: Protein Humanin (human). Grades: ≥95%. CAS No. 330936-69-1. Molecular formula: C119H204N34O32S2. Mole weight: 2687.22.
Human neutrophil peptide-2
Human neutrophil peptide-2 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria, gram-negative bacteria, fungi and viruses. Synonyms: Neutrophil Peptide-2; Defensin HNP-2 human; Defensin HNP-2; alpha-Defensin-2; H-Cys(1)-Tyr-Cys(2)-Arg-Ile-Pro-Ala-Cys(3)-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys(2)-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys(3)-Cys(1)-OH. Grades: 95.2%. CAS No. 99287-07-7. Molecular formula: C147H217N43O37S6. Mole weight: 3371.0.
H-Val-Val-OH
Synonyms: L-Valyl-L-valine; Val-val; Val val. CAS No. 3918-94-3. Molecular formula: C10H20N2O3. Mole weight: 216.28.
Hydramycin
Hydramycin is an anti-tumor antibiotic produced by Streptomyces purpurea P950-4. It has activity against Gram-positive bacteria. It inhibits B16-F10, Moser and HCT-116 cells with IC50s (μg/mL) of 0.0009, 0.0046 and 0.0026, respectively, which is 300-600 times that of mitomycin C. It has a broad anti-cancer spectrum and has a moderate effect on P388 leukemia, with a T/C of 145%. Molecular formula: C22H16O8. Mole weight: 408.36.
Hydranthomycin
Hydranthomycin is an antibiotic produced by Streptomyces sp. K93-5305. It has moderate antifungal activity, and the MIC of Pyricularia oryzae is 25 μg/mL. It inhibits the growth of Euglena gracilis and has herbicidal activity. Molecular formula: C20H20O5. Mole weight: 340.37.
Hydrolyzed Fumonisin B1
Hydrolyzed Fumonisin B1 is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1. Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase. Synonyms: AP1 Metabolite; Aminopentol; Aminopentol formate salt; 2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. Grades: ≥95%. CAS No. 145040-09-1. Molecular formula: C22H47NO5. Mole weight: 405.61.
Hydrolyzed Fumonisin B2
Hydrolyzed Fumonisin B2 is a metabolite of Fumonisin B2, a mycotoxin produced by mold associated with corn. Synonyms: Fumonisin AP2; Fumonisin HB2; Hydrolyzed Fumonisin B2; 3,?5,?14,?15-Eicosanetetrol, 2-amino-12,?16-dimethyl-, (2S,?3S,?5R,?12S,?14S,?15R,?16R)?-; (2S,3S,5R,12S,14S,15R,16R)-2-Amino-12,16-dimethyl-3,5,14,15-eicosanetetrol. Grades: ≥97%. CAS No. 147985-10-2. Molecular formula: C22H47NO4. Mole weight: 389.61.
Hydroxy acivicin
Hydroxy acivicin is an antitumor agent. Synonyms: U 43795; U-43795. CAS No. 54549-02-9. Molecular formula: C5H7ClN2O4. Mole weight: 194.57.
Hydroxyakalone
Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2) produced by Agrobacterium aurantiacumn N81106. It inhibits XOD with an IC50 of 4.6 μmol/L, which is stronger than acathone (IC50 16.9 μmol/L). Synonyms: 1h-pyrazolo[3,4-d]pyrimidine-3,6(2h,7h)-dione,4-amino-. CAS No. 182056-35-5. Molecular formula: C5H5N5O2. Mole weight: 167.13.
Hydroxychlorothricin
Hydroxychlorothricin is an antibiotic of the chlorothricin group produced by Streptomyces sp. K818. It has anti-tumor effect and can prolong the survival period of ICR mice inoculated with Ehrlich cancer cells. Molecular formula: C50H63ClO17. Mole weight: 971.48.
Hydroxylupanine
Hydroxypurine is an alkaloid isolated from L. lanatus. It is an inhibitor of ganglion transmission. Synonyms: Jamaidine; Luparine, hydroxy-; Oxylupanine. Grades: >95% by HPLC. CAS No. 15358-48-2. Molecular formula: C15H24N2O2. Mole weight: 264.36.
Hydroxymycotrienin A
Hydroxymycotrienin A is an Ansa antibiotic produced by Bacillus sp. BMJ958-62F4. It has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSki, SiHa, etc.) is stronger than HPV gene negative cells. CAS No. 178550-61-3. Molecular formula: C36H48N2O9. Mole weight: 652.77.
Hydroxymycotrienin B
Hydroxymycotrienin B is an Ansa antibiotic produced by Bacillus sp. BMJ958-62F4. It has the activity of inhibiting human neck tumor cell line, and its inhibitory effect on human papillomavirus (HPV) gene positive neck tumor cells (such as HeLa, CaSki, SiHa, etc.) is stronger than HPV gene negative cells. CAS No. 178550-62-4. Molecular formula: C36H48N2O9. Mole weight: 652.77.
Hydroxynybomycin
Hydroxynybomycin is an antibiotic produced by Streptomyces D-57. Activity against gram-negative bacteria. Synonyms: 2H,4H-Oxazolo(5,4,3-ij)pyrido(3,2-g)quinoline-4,10(11H)-dione, 6,8-bis(hydroxymethyl)-11-methyl-. CAS No. 63582-81-0. Molecular formula: C16H14N2O5. Mole weight: 314.29.
Hydroxystrobilurin A
Hydroxystrobilurin A is an antifungal antibiotic produced by Pterula spec. 82168. It has anti-yeast and filamentous fungus activity with a MIC of 1-10 μg/mL. Molecular formula: C16H18O4. Mole weight: 274.31.
Hygrolidin
Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity. Synonyms: (E)-4-[(2R,4R,5S,6R)-6-ethyl-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9S,10S,11R,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoic acid. Grades: ≥97.0%. CAS No. 83329-73-1. Molecular formula: C38H58O11. Mole weight: 690.86.
Hymeglusin
It is a β-lactone antibiotic produced by the strain of Cephalosporium sp. It has a strong inhibitory effect on hydroxymethyl glutaryl coenzyme A (HMG-CoA) synthase. Synonyms: Antibiotic 1233A; 1233A; Antibiotic F 244; (R,R)-Hymeglusin; 2,4-Undecadienoic acid, 11-(3-(hydroxymethyl)-4-oxo-2-oxetanyl)-3,5,7-trimethyl-, (2R-(2-alpha(2E,4E,7R*),3-beta))-; Antibiotic L 659699. Grades: ≥95%. CAS No. 29066-42-0. Molecular formula: C18H28O5. Mole weight: 324.41.
Hynapene A
Hynapene A is produced by the strain of Penicillum sp. FO-1611. The MIC (X 10-6 mol/L) for Eimeria tenella inhibition is 123. Synonyms: 5-(1,3,4-Trihydroxy-2,6,8-trimethyldecalin)-2,4-pentadienoic acid; 2,4-Pentadienoic acid, 5-(decahydro-1,3,4-trihydroxy-2,6,8-trimethyl-1-naphthalenyl)-. CAS No. 155111-89-0. Molecular formula: C18H28O5. Mole weight: 324.41.
Hynapene B
Hynapene B is produced by the strain of Penicillum sp. FO-1611. The MIC (X 10-6 mol/L) for Eimeria tenella inhibition is 34.7. Synonyms: 5-(1-Ene-3-oxo-2,6,8-trimethyldecalin)-2,4-pentadienoic acid; 2,4-Pentadienoic acid, 5-(3,4,4a,5,6,7,8,8a-octahydro-2,6,8-trimethyl-3-oxo-1-naphthalenyl)-. Grades: 99%. CAS No. 155111-88-9. Molecular formula: C18H24O3. Mole weight: 288.38.
Hynapene C
Hynapene C is produced by the strain of Penicillum sp. FO-1611. The MIC (X 10-6 mol/L) for Eimeria tenella inhibition is 34.7. Synonyms: 5-(3-Ene-1-oxo-2,6,8-trimethyldecalin-2-yl)-2,4-pentadienoic acid; 2,4-Pentadienoic acid, 5-(1,2,4a,5,6,7,8,8a-octahydro-2,6,8-trimethyl-1-oxo-2-naphthalenyl)-. CAS No. 155111-90-3. Molecular formula: C18H24O3. Mole weight: 288.38.
Hypelcin A-I
Hypelcin A-I is originally isolated from Hypocrea peltata. It has anti-gram-negative bacterial and fungal activity. Synonyms: Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Leu-Aib-Gly-Aib-Aib-Pro-Val-Aib-Aib-Gln-Gln-Leu-ol. CAS No. 93397-17-2. Molecular formula: C89H153N23O24. Mole weight: 1929.30.
Hypelcin A-II
Hypelcin A-II is originally isolated from Hypocrea peltata. It has anti-gram-negative bacterial and fungal activity. Synonyms: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Leu-Aib-Gly-Aib-Aib-Pro-Val-Aib-Aib-Gln-Gln-Leu-ol. CAS No. 93397-16-1. Molecular formula: C88H151N23O24. Mole weight: 1915.27.
Hypelcin A-III
Hypelcin A-III is originally isolated from Hypocrea peltata. It has anti-gram-negative bacterial and fungal activity. Synonyms: Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Leu-Aib-Gly-Aib-Aib-Pro-Val-Aib-Iva-Gln-Gln-Leu-ol. Molecular formula: C90H155N23O24. Mole weight: 1943.33.
Hypelcin A-IV
Hypelcin A-IV is originally isolated from Hypocrea peltata. It has anti-gram-negative bacterial and fungal activity. Synonyms: Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Ile-Aib-Gly-Aib-Aib-Pro-Val-Aib-Aib-Gln-Gln-Leu-ol. CAS No. 93397-15-0. Molecular formula: C89H153N23O24. Mole weight: 1929.30.
Hypeptin
Hypeptin is produced by the strain of Pseudomonas sp. PB-6269. Hypeptin has the activity of anti-anaerobic gram-positive bacteria and anti-anaerobic gram-negative bacteria (weakly), and also has the effect on aerobic gram-positive bacteria. Synonyms: UNII-0V1I6WBK4F; L-Isoleucine, N-(N-(N-(N2-(N2-(N2-(N-L-alanyl-D-leucyl)-D-arginyl)-erythro-3-hydroxy-L-asparaginyl)-erythro-3-hydroxy-D-asparaginyl)-erythro-beta-hydroxy-L-tyrosyl)-threo-3-hydroxy-L-leucyl)-, lambda-lactone. Grades: >98%. CAS No. 124883-38-1. Molecular formula: C44H71N13O15. Mole weight: 1022.11.
Hypnophilin
Hypnophilin is produced by the strain of Pleurotellus hypnophilus 539. It has a variety of activities, including anti-gram-positive bacteria, negative bacteria, yeast, mold and tumor activities. Synonyms: (-)-Hypnophilin; (3aR,3bβ,6aβ)-4β-Hydroxy-3aα,5,5-trimethyl-3-methylene-1α,7aα-epoxydecahydro-2H-cyclopenta[a]pentalene-2-one. CAS No. 80677-96-9. Molecular formula: C15H20O3. Mole weight: 248.32.
Hypocrellin A
Hypocrellin A is a natural perylene quinine photosensitizer isolated from Hypocrella bambusae. It is a potent PKC inhibitor. Uses: Antiviral agents. Synonyms: 7,19-dione; Isohypocrelin. Grades: 95%. CAS No. 77029-83-5. Molecular formula: C30H26O10. Mole weight: 546.52.
Hypostictic acid
It has moderate inhibitory activity against the growth of Mycobacterium tuberculosis. Synonyms: Hypostatic acid; 1, 4-Dihydroxy-10-methoxy-5, 8, 11-trimethyl-1H-benzo[e]furo[3', 4':3, 4]benzo[b][1, 4]dioxepine-3, 7-dione; 7H-Isobenzofuro[4,5-b][1,4]benzodioxepin-3,7(1H)-dione, 1,4-dihydroxy-10-methoxy-5,8,11-trimethyl-. Grades: ≥98%. CAS No. 68729-11-3. Molecular formula: C19H16O8. Mole weight: 372.33.
IB-00208
IB-00208, a new cytotoxic polycyclic xanthone produced by Actinomadura sp. It also has anti-Gram-positive bacteria activity (MIC=0.09-1.4 nmol/L). Molecular formula: C36H34O12. Mole weight: 658.65.
IC-202-A
IC-202-A shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS). Molecular formula: C27H52N6O7. Mole weight: 572.74.
IC202B
IC202B shows immunosuppressive activity, with IC50 of 3.6 μg/mL as determined by MLCR, and has a strong inhibitory effect on Blastogensis induced by ConA or lipopolysaccharide (LPS). Synonyms: N- (5-aminopentyl) -N-hydroxy-N'-[5- (hydroxy{4-[ (5-nitropentyl) amino]-4-oxobutanoyl}amino) pentyl]butanediamide; IC-202B. Molecular formula: C23H44N6O8. Mole weight: 532.63.
ICM0201
It is originally isolated from Cunninghamella sp. F-1490. ICM0201 can inhibit the formation of osteoclasts in mouse bone marrow cells with IC50 of 0.78 μg/mL. Synonyms: ICM 0201; ICM-0201. Molecular formula: C12H13NO6. Mole weight: 267.23.
IDR-1
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. CAS No. 940291-10-1. Molecular formula: C65H118N18O15.
IGF-1 DES1,3
IGF-1 DES1,3 is a fragment of amino acids of the Insulin Growth Factor-1 DES. Synonyms: Insulin Growth Factor-1 DES. Grades: 99%. CAS No. 67763-96-6. Molecular formula: C18H32N5O7S1. Mole weight: 462.55.
Ikarugamycin
An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grades: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62.
Ilamycin A
Ilamycin A is produced by the strain of Str. islandicus A-165-Z1. It is resistant to mycobacteria, including human mycobacterium tuberculosis, and also to streptomycin resistant bacteria. Grades: >97%. CAS No. 11006-41-0. Molecular formula: C54H75N9O12. Mole weight: 1042.22.
Ilicicolin A is originally isolated from Cylinddrocladium ilicicola MFC-870. It inhibited Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells was 0.2 μg/mL. Synonyms: LL-Z 1272-alpha; 3-chloro-4,6-dihydroxy-2-methyl-5-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)benzaldehyde. Grades: >98%. CAS No. 22581-06-2. Molecular formula: C23H31ClO3. Mole weight: 390.94.
Ilicicolin B
Ilicicolin B is originally isolated from Cylinddrocladium ilicicola MFC-870. It inhibited Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells was 0.3 μg/mL. Synonyms: 2,4-Dihydroxy-6-methyl-3-((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)benzaldehyde; LL-Z1272beta. Grades: >98%. CAS No. 22581-07-3. Molecular formula: C23H32O3. Mole weight: 356.50.
Ilicicolin C
Ilicicolin C is originally isolated from Cylinddrocladium ilicicola MFC-870. It inhibits Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells is 0.2 μg/mL. Synonyms: LL-Z 1272delta; 3-Chloro-4,6-dihydroxy-2-methyl-5-((2E)-3-methyl-5-((1S,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl)-2-pentenyl)benzaldehyde. Grades: >95%. CAS No. 22562-67-0. Molecular formula: C23H31ClO4. Mole weight: 406.94.
Illudin C2
Illudin C2 is produced by the strain of Coprinus atramentarius ASI 20013. It has the effect of resisting bacterium and fungus, and the antibacterial activity is weak. Molecular formula: C15H20O3. Mole weight: 248.32.