BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Fragment (28-32)-Calcitonin | Fragment (28-32)-Calcitonin is an impurity of Calcitonin salmon, which is a calcium regulating hormone used to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: H-Gly-Ser-Gly-Thr-Pro-OH; glycyl-L-serylglycyl-L-threonyl-L-proline; H-GSGTP-OH. Molecular formula: C16H27N5O8. Mole weight: 417.42. |  |
| Frakefamide | Frakefamide is a peripheral active μ-selective receptor agonist and used as a potent analgesic. Synonyms: BCH-3963; L-Tyrosyl-D-alanyl-L-(4-fluoro)phenylalanyl-L-phenylalanylamide. CAS No. 188196-22-7. Molecular formula: C30H34FN5O5. Mole weight: 563.63. | |
| Frakefamide TFA | Frakefamide TFA is a potent analgesic which acts as a peripheral active μ-selective receptor agonist. Grade: 99%. Molecular formula: C32H35F4N5O7. Mole weight: 677.64. | |
| FRAX1036 | FRAX1036 is a highly selective PAK1 inhibitor that remarkably altered signaling to cytoskeletal-associated proteins. In vitro and in vivo tests with FRAX-1036 have shown that the small-molecule inhibitor can both deter proliferation in ovarian cancer cell. Synonyms: 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-[2-(1-methylpiperidin-4-yl)ethylamino]pyrido[2,3-d]pyrimidin-7-oneFRAX1036; FRAX-1036; FRAX 1036SCHEMBL14928919CS-5585; HY-19538; CS 5585; HY 19538; CS5585; HY19538. CAS No. 1432908-05-8. Molecular formula: C28H32ClN7O. Mole weight: 518.06. | |
| FRAX486 | FRAX486, an effective PAK inhibitor, could improve epileptic seizures and sorts of other abnormal behaviors. Uses: Frax486 is an effective pak inhibitor that could improve epileptic seizures and sorts of other abnormal behaviors. Synonyms: FRAX486; FRAX-486; FRAX 486; 6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one; C25H23Cl2FN6O; FRAX 486. Grade: 98%. CAS No. 1232030-35-1. Molecular formula: C25H23Cl2FN6O. Mole weight: 513.39. | |
| FRAX486 HCl | FRAX486 HCl is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. Synonyms: FRAX-486 HCl. Molecular formula: C25H24Cl3FN6O. Mole weight: 549.86. | |
| FRAX597 | FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively. Synonyms: FRAX597; FRAX-597; FRAX 597. Grade: >98%. CAS No. 1286739-19-2. Molecular formula: C29H28ClN7OS. Mole weight: 558.10. | |
| Fremanezumab | Fremanezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Fremanezumab has been investigated for the prevention of high-frequency episodic and chronic migraine. Synonyms: TEV-48125. CAS No. 1655501-53-3. | |
| Frenlosirsen | Frenlosirsen is an interferon regulatory factor 4 (IRF4) synthesis reducer, with antineoplastic properties. Synonyms: all-P-ambo-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiocytidylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]guanosine; DNA, d(P-thio)((2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)A-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)G-T-T-G-T-A-A-A-T-G-(2'-O-(2-methoxyethyl))rA-(2'-O-(2-methoxyethyl))rG-(2'-O-(2-methoxyethyl))m5rU-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)m5C-(3'->4')-(2',5'-anhydro-6'-deoxy-4'-C-(hydroxymethyl)-alpha-L-mannofurano)G). CAS No. 2304711-81-5. Molecular formula: C177H226N63O89P15S15. Mole weight: 5605.71. | |
| Frentizole | Frentizole is a novel inhibitor of the Aβ-ABAD interaction (IC50 = 200 lM). Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly improved activity (IC50 = 200 lM) compared to thioflavine T (IC50 = 230 lM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: LY 53616; LY53616; LY-53616; Frentizole; 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; 7EY946394I; frentizole; mono-hydrate of frentizole; FRENTIZOLE; 26130-02-9; Frentizol; Compound 53616; MLS000555007; CHEMBL128988; UNII-7EY946394I; 1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea; NCGC00160657-01; SMR000147124; 1-(6-Methoxy-benzothiazol-2-yl)-3-phenyl-urea; DSSTox_CID_26279; DSSTox_RID_8150. CAS No. 26130-02-9. Molecular formula: C15H13N3O2S. Mole weight: 299.35. | |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Synonyms: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. Grade: 95%. CAS No. 208848-19-5. Molecular formula: C23H28N6O4. Mole weight: 452.51. | |
| Fresolimumab | Fresolimumab is a human monoclonal antibody targeting transforming growth factor beta (TGF-β). Fresolimumab inhibits the activity of TGF-beta, which may result in the suppression of tumor cell growth, angiogenesis, and migration. Synonyms: GC1008; GC 1008; GC-1008. CAS No. 948564-73-6. | |
| FRG8701 | FRG-8701 is a novel Histamine H2 receptor antagonist (IC50= 0.25~ 0.43 μM). FRG-8701 has relatively long-lasting antisecretory ef fects in comparison with famotidine and cimetidine. Synonyms: FRG8701; FRG 8701; FRG-8701; 2-(furan-2-ylmethylsulfinyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide; FRG 8701; FRG-8701; N-(3-(3-(piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide. CAS No. 108498-50-6. Molecular formula: C22H30N2O4S. Mole weight: 418.55. | |
| Frovatriptan-d3 Succinate | One of the isotopic labelled salt of Frovatriptan, which has been found to be a serotonin 5-HT1B/1D receptor agonist. Synonyms: (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide Butanedioic Acid-d3. Molecular formula: C14H14N3OD3.C4H6O4. Mole weight: 364.42. | |
| Frovatriptan Impurity 1 | Frovatriptan Impurity 1. Grade: > 95%. Molecular formula: C14H17N3O. Mole weight: 243.31. | |
| Frovatriptan Impurity 11 | Frovatriptan Impurity 11. Grade: > 95%. Molecular formula: C14H15N3O2. Mole weight: 257.29. | |
| Frovatriptan Impurity 12 | Frovatriptan Impurity 12. Grade: > 95%. Molecular formula: C14H17N3O2. Mole weight: 259.31. | |
| Frovatriptan Impurity 2 | Frovatriptan Impurity 2. Grade: > 95%. Molecular formula: C7H9N3O. Mole weight: 151.17. | |
| Frovatriptan Impurity 3 | Frovatriptan Impurity 3. Grade: > 95%. Molecular formula: C14H17N3O. Mole weight: 243.31. | |
| Frovatriptan Impurity 4 | Frovatriptan Impurity 4. Grade: > 95%. Molecular formula: C14H17N3O. Mole weight: 243.31. | |
| Frovatriptan Impurity 5 | Frovatriptan Impurity 5. Synonyms: 3-Hydrazinobenzamide; Benzamide, 3-hydrazino-; 3-Carboxamidophenyl hydrazine. Grade: > 95%. CAS No. 473927-51-4. Molecular formula: C7H9N3O. Mole weight: 151.17. | |
| Frovatriptan Impurity 6 | Frovatriptan Impurity 6. Grade: > 95%. Molecular formula: C16H28O4. Mole weight: 284.40. | |
| Frovatriptan Impurity 7 | Frovatriptan Impurity 7. Grade: > 95%. Molecular formula: C15H19N3O. Mole weight: 257.34. | |
| Frovatriptan Impurity 8 | Frovatriptan Impurity 8. Grade: > 95%. Molecular formula: C13H25NO2. Mole weight: 227.35. | |
| Frovatriptan Impurity 9 | Frovatriptan Impurity 9. Grade: > 95%. Molecular formula: C14H16N2O2. Mole weight: 244.30. | |
| Frovatriptan Racemate | Frovatriptan Racemate is a combination of both the R and S enantiomers of Frovatriptanis, a drug for migraines and cluster headaches. Synonyms: (RS)-3-(Methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide; 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole; 2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide. Grade: > 95%. CAS No. 147009-08-3. Molecular formula: C14H17N3O. Mole weight: 243.31. | |
| Frovatriptan Succinate | Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent. Synonyms: (3R)-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide butanedioate; 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-, butanedioate (1:1); Sb-209509ax; Vml 251. Grade: > 95%. CAS No. 158930-09-7. Molecular formula: C18H23N3O5. Mole weight: 361.40. | |
| Frovatriptan succinate hydrate | Frovatriptan is a selective agonist of the 5-HT1B and 5-HT1D (Kis = 2.51 and 3.98 nM, respectively). Synonyms: SB 209509; VML 251; butanedioic acid, compd. with (R)-2,3,4,9-tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide, hydrate (1:1:1); R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate. Grade: ≥98%. CAS No. 158930-17-7. Molecular formula: C14H17N3O·C4H6O4·H2O. Mole weight: 379.41. | |
| Fructodecasaccharide | Fructodecasaccharide is a prevalent natural prebiotic compound with intricate properties meticulously bolster the proliferation of advantageous bacterial species within the gut. Synonyms: Frub(2-1)-[Frub(2-1)]8-a(2-1)Glc; Fructo-oligosaccharide DP10. Molecular formula: C60H102O51. Mole weight: 1639.42. | |
| Fructoheptasaccharide | Fructoheptasaccharide is an intricate and bioactive oligosaccharide, widely employed in the biomedical realm. This remarkable compound manifests as a paramount dietary fiber. Notably, Fructoheptasaccharide exhibits promising attributes in the realm of gastrointestinal disorder research. Synonyms: 1-Kestoheptaose; 1,1,1,1,1-Kestoheptaose; Fructo-oligosaccharide DP7/GF6; 1F-(1-β-D-fructofuranosyl)5-sucrose. Grade: 98%. CAS No. 62512-20-3. Molecular formula: C42H72O36. Mole weight: 1153.00. | |
| Fructohexasaccharide | Fructohexasaccharide is a natural sweetener commonly used in the biomedical industry. It exhibits prebiotic properties, promoting the growth of beneficial bacteria in the gut. This product can be used in the development of drugs aiming to study gastrointestinal disorders and improve overall gut health. Synonyms: Fructo-oligosaccharide DP6; Frub(2-1)-[Frub(2-1)]4-a(2-1)Glc; Inulohexaose. Grade: 98%. CAS No. 74914-46-8. Molecular formula: C36H62O31. Mole weight: 990.86. | |
| Fructononasaccharide | Fructononasaccharide is a naturally occurring compound present in diverse botanical sources, used in the research of diabetes and obesity. Fructononasaccharide exerts influence on insulin sensitivity augmentation and inhibition of adipocyte differentiation. Synonyms: Fructo-oligosaccharide DP9; Frub(2-1)-[Frub(2-1)]7-a(2-1)Glc. Molecular formula: C54H92O46. Mole weight: 1477.28. | |
| Fructooctasaccharide | Fructooctasaccharide is an intriguing and captivating natural component sourced from bountiful fruits and vibrant vegetables. As a prebiotic compound, it can fuel the prosperous proliferation of health-enhancing microflora. Synonyms: Fructo-oligosaccharide DP8; Frub(2-1)-[Frub(2-1)]6-a(2-1)Glc. Molecular formula: C48H82O41. Mole weight: 1315.14. | |
| Fructooligosaccharides | Fructooligosaccharides are short-chain carbohydrates composed of fructose molecules linked together by fructose-1-2 bonds. They are naturally found in certain plants, such as onions, garlic, and asparagus, and are also produced commercially from sugar beet or Jerusalem artichoke. FOS serve as a prebiotic, promoting the growth of beneficial bacteria in the gut, and are often used as a dietary supplement or food ingredient to support digestive health. Synonyms: Oligosaccharides, fructose-contg.; Actilight; Beneo OPS; FortiFeed; Fructose-containing oligosaccharides; Fructose-contg. oligosaccharides; NutraFlora; Nutriflora P; scFOS. CAS No. 308066-66-2. | |
| Fructosazine | Fructosazine is a highly innovative biomedical adjunct, emerging as an exalted compound for studying diabetes. It is a potent fructosamine-3-kinase enzyme inhibitor. Synonyms: Glucosamine EP Impurity B; D-Arabino-1,1-(2,5-pyrazinediyl)di-1,2,3,4-butanetetrol; Tagatosazine; (1R,1'R,2S,2'S,3R,3'R)-1,1'-(2,5-Pyrazinediyl)bis[1,2,3,4-butanetetrol]; 1,2,3,4-Butanetetrol, 1,1'-(2,5-pyrazinediyl)bis-, [1R-[1R*(1'R*,2'S*,3'R*),2S*,3R*]]-; 1,2,3,4-Butanetetrol, 1,1'-(2,5-pyrazinediyl)di-, D-arabino-; 2,5-bis(D-Arabinotetrahydroxybutyl)pyrazine; Glucosamine Impurity B. Grade: ≥98%. CAS No. 13185-73-4. Molecular formula: C12H20N2O8. Mole weight: 320.30. | |
| Fructose-1,6-bisphosphatase-1 Inhibitor | Fructose-1,6-bisphosphatase-1 (FBPase-1) inhibitor is a cell-permeable benzoxazolo-sulfonamide compound functioning by blocking human FBPase-1 enzymatic activity with an IC50 value of 3.4 μM (Ki = 1.1 μM). Synonyms: F1,6BPase-1 Inhibitor; FBP1 Inhibitor; FBPase-1 Inhibitor; 2,5-dichloro-N-(5-chloro-2-benzoxazolyl)-benzenesulfonamide. Grade: ≥98%. CAS No. 883973-99-7. Molecular formula: C13H7Cl3N2O3S. Mole weight: 377.6. | |
| Fructose-1-S-nitroso-N-acetyl-D,L-penicillamine | A nitric oxide donor with enhanced cytotoxicity to DU-145 human prostate cancers in vitro. Synonyms: Fructose-1-SNAP; 1-[[(2S)-2-(Acetylamino)-3-methyl-3-(nitrosothio)-1-oxobutyl]amino]-1-deoxy-β-D-Fructopyranose. CAS No. 330688-79-4. Molecular formula: C13H23N3O8S. Mole weight: 381.40. | |
| Fructose-3-phosphate sodium salt | Fructose-3-phosphate sodium salt is an indispensable compound, playing a pivotal role in preserving cellular energy equilibrium and governing glucose metabolism. Noteworthy applications encompass the research of diabetes and metabolic disorders. Synonyms: D-Fructose, 3-(dihydrogen phosphate) sodium salt; D-Fructose 3-phosphate sodium salt. Molecular formula: C6H13O9P.xNa. Mole weight: 260.14 (free acid). | |
| Fructose-alanine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-alanine; (S)-1-[(1-Carboxyethyl)amino]-1-deoxy-D-fructose; 1-Alanino-1-deoxy-D-fructose; 1-Deoxy-1-L-alanine-D-fructose; N-(1-Deoxy-D-fructosyl)-L-alanine. Grade: 95%. CAS No. 16124-24-6. Molecular formula: C9H17NO7. Mole weight: 251.23. | |
| Fructose-asparagine (Mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N2-(1-Deoxy-D-fructos-1-yl)-L-asparagine; (S)-1-[(3-Amino-1-carboxy-3-oxopropyl)amino]-1-deoxy-D-fructose; 1-[(2-Carbamoyl-1-carboxyethyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-asparagino-D-fructose; N-(1-Deoxy-D-fructosyl)-L-asparagine. Grade: 95%. CAS No. 34393-27-6. Molecular formula: C10H18N2O8. Mole weight: 294.26. | |
| Fructose-glutamic Acid-D5 | Fructose-glutamic acid-D5 is a labelled analogue of Fructose-glutamic acid, is an Amadori compound (derivatives of aminodeoxysugars) that is formed in food (such as dehydrated fruits tomatoes and carrots) result in the Maillard reactions. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-glutamic Acid-D5; (S)-1-Deoxy-1-[(1,3-dicarboxypropyl)amino]-D-fructose-D5; 1-Deoxy-1-[(L-1,3-dicarboxypropyl)amino]-D-fructose-D5; L-Glutamic Acid D-Fructose Deriv.-D5; 1-Deoxy-1-(L-glutamyl)-D-fructose-D5; N-Fructosylglutamic Acid-D5. Molecular formula: C11H14D5NO9. Mole weight: 314.3. | |
| Fructoseglutamic Acid Disodium Salt | Fructoseglutamic Acid Disodium Salt is an Amadori compound (derivatives of aminodeoxysugars) that is formed in food (such as dehydrated fruits tomatoes and carrots) result in Maillard reactions. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-glutamic Acid Disodium Salt; (S)-1-Deoxy-1-[(1,3-dicarboxypropyl)amino]-D-fructose Disodium Salt; 1-Deoxy-1-[(L-1,3-dicarboxypropyl)amino]-D-fructose Disodium Salt; L-Glutamic Acid D-Fructose Deriv. Disodium Salt; 1-Deoxy-1-(L-glutamyl)-D-fructose Disodium Salt; N-Fructosylglutamic Acid Disodium Salt. Grade: 93%. Molecular formula: C11H17NNa2O9. Mole weight: 353.23. | |
| Fructose-isoleucine (mixture of diastereomers) | Fructose-isoleucine is an Amadori compound (aminodeoxysugars derivatives) that is formed in food, which could induce the Maillard reactions. Synonyms: N-(1-Deoxy-β-D-fructopyranos-1-yl)-L-isoleucine; [S-(R*,R*)]-1-[(1-Carboxy-2-methylbutyl)amino]-1-deoxy-β-D-fructopyranose. CAS No. 87304-79-8. Molecular formula: C12H23NO7. Mole weight: 293.31. | |
| Fructose L-Arginine Adduct | α-Fructose L-Arginine is an analogue of Fructose-leucine, an amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: (S)1-[[4-[(Aminoiminomethyl)amino]-1-carboxybutyl]amino]-1-deoxy-D-fructose; D-1-[(1-Carboxy-4-guanidinobutyl)amino]-1-deoxy-fructose. CAS No. 25020-14-8. Molecular formula: C12H24N4O7. Mole weight: 336.34. | |
| Fructose-leucine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-leucine; (S)-1-[(1-Carboxy-3-methylbutyl)amino]-1-deoxy-D-fructose; D-1-[(L-1-Carboxy-3-methylbutyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-leucino-D-fructose; Fructoseleucine. Grade: 98%. CAS No. 34393-18-5. Molecular formula: C12H23NO7. Mole weight: 293.31. | |
| Fructose-phenylalanine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-phenylalanine; (S)-1-[(1-Carboxy-2-phenylethyl)amino]-1-deoxy-D-fructose; 1-[(α-Carboxyphenethyl)amino]-1-deoxy-fructose; N-(1'-Carboxy-2'-phenylethyl)amino-1-deoxyfructose. Grade: 98%. CAS No. 31105-03-0. Molecular formula: C15H21NO7. Mole weight: 327.33. | |
| Fructose-proline (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: 1-(1-Deoxy-D-fructos-1-yl)-L-proline; (S)-1-(2-Carboxy-1-pyrrolidinyl)-1-deoxy-D-fructose; 1-Deoxy-1-L-proline-D-fructose; 1-Deoxy-1-L-prolino-D-fructose. Grade: 97%. CAS No. 29118-61-4. Molecular formula: C11H19NO7. Mole weight: 277.27. | |
| Fructose-tryptophan (mixture of diastereomers) | An Amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-tryptophan; (S)-1-[[1-Carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-deoxy-D-fructose; D-Fructose-tryptophan; Fructose-L-tryptophan. Grade: 95%. CAS No. 25020-15-9. Molecular formula: C17H22N2O7. Mole weight: 366.37. | |
| Fructose Val-His-Leu-Thr-Pro-Glu Hydrochloride Salt | Fructose Val-His-Leu-Thr-Pro-Glu Hydrochloride Salt is a glycosylated peptide for diagnosing diabetes by analyzing the enzymic activity. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-valyl-L-histidyl-L-leucyl-L-threonyl-L-prolyl-L-glutamic Acid Hydrochloride Salt; 5: PN: WO2008108385 PAGE: 23 Claimed Protein Hydrochloride Salt. Molecular formula: C37H60N8O15.xHCl. Mole weight: 856.92 (free base). | |
| Fructose Val-His Sodium Salt (Mixture of Diastereomers) | Fructose Val-His is used as a substrate in the kinetic reaction of fructosylpeptide oxidases of Coniochaeta and Eupenicillium terrenum with glycated protein molecules. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-valyl-L-histidine Sodium Salt; (S)-3-(1H-Imidazol-4-yl)-2-((S)-3-methyl-2-((((3S,4R,5R)-2,3,4,5-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl)amino)butanamido)propanoic Acid Sodium Salt; N-(1-Deoxyfructosyl)-Val-His Sodium Salt. Grade: 95%. Molecular formula: C17H27N4NaO8. Mole weight: 438.41. | |
| Fructose Valine (mixture of diastereomers) | An Amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-valine; D-1-[(L-1-Carboxy-2-methylpropyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-valino-D-fructose; 1-L-Valine-1-deoxy-D-fructose; Fructosyl-valine; N-Fructosyl Valine. Grade: 98%. CAS No. 10003-64-2. Molecular formula: C11H21NO7. Mole weight: 279.29. | |
| Fructosyl Glycine α/β Mixture (Mixture of Diastereomers) | Fructosyl Glycine is a synthetic glycoamine used in the study of glycoamine analogs and their effect on metastatic carcinoma cells. Synonyms: N-(1-Deoxy-β-D-fructopyranos-1-yl)glycine; 1-[(Carboxymethyl)amino]-1-deoxy-β-D-fructopyranose. CAS No. 60644-20-4. Molecular formula: C8H15NO7. Mole weight: 237.21. | |
| Fructosyl-lysine | Fructosyl-lysine is an indispensable compound, holding immense value for evaluating glycation. Glycation is a fundamental process intricately linked to multifarious ailments including diabetes, alzheimer's and aging. Synonyms: Fructosyllysine; fructoselysine; Fructose lysine; epsilon-Fructoselysine; epsilon-fructosyl-L-lysine; N(6)-(1-deoxy-D-fructos-1-yl)-L-lysine; L-Lysine, N6-(1-deoxy-D-fructos-1-yl)-; 1-{[(5S)-5-amino-5-carboxypentyl]amino}-1-deoxy-D-fructose; N6-((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-lysine; N6-(D-fructosyl)-L-lysine; epsilon-N-deoxyfructosyllysine; 1-deoxy-1-(epsilon-N-L-lysino)-D-fructose. CAS No. 21291-40-7. Molecular formula: C12H24N2O7. Mole weight: 308.33. | |
| Fruquintinib | Fruquintinib, also known as HMPL-013, is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Synonyms: Fruquintinib; HMPL013; HMPL 013; HMPL-013. Grade: 98%. CAS No. 1194506-26-7. Molecular formula: C21H19N3O5. Mole weight: 393.39. | |
| FSL-1 TFA salt | FSL-1 is a TLR2/6 peptide agonist (also a putative TLR10 ligand) that activates NF-κB. FSL-1 induces the expression of some pro-inflammatory cytokines such as IL-8, IL-1β, CCL20 and TNF-α in vitro. Synonyms: FSL 1 TFA salt; FSL1 TFA salt; L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-, 2,2,2-trifluoroacetic acid; S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine 2,2,2-trifluoroacetic acid; FSL-1 lipoprotein, synthetic TFA salt; Fibroblast-stimulating lipopeptide-1 TFA salt; Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH TFA. Grade: ≥95%. Molecular formula: C86H141F3N14O20S. Mole weight: 1780.18. | |
| FT001 | FT001 is a potent, selective and orally effective BET Bromodomain inhibitor with antitumor activity. FT001 inhibits MYC expression with an IC50 of 0.46 μM. FT001 has an effective anti-proliferation effect on MV-4-11, showing obvious MYC mRNA inhibition both in vitro and in vivo. Synonyms: (S)-1-(4-(cyclopropanecarbonyl)-6-(4-(1,1-dioxidothiomorpholino)phenyl)-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one; Ethanone, 1-[(2S)-4-(cyclopropylcarbonyl)-6-[4-(1,1-dioxido-4-thiomorpholinyl)phenyl]-3,4-dihydro-2-methyl-1(2H)-quinoxalinyl]-; FT001; FT-001; 1-[(2S)-4-(Cyclopropylcarbonyl)-6-[4-(1,1-dioxido-4-thiomorpholinyl)phenyl]-3,4-dihydro-2-methyl-1(2H)-quinoxalinyl]ethanone. Grade: ≥95%. CAS No. 1778655-51-8. Molecular formula: C25H29N3O4S. Mole weight: 467.58. | |
| FT113 | FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 213 nM. Synonyms: FT-113; FT113. CAS No. 1630808-89-7. Molecular formula: C22H20FN3O4. Mole weight: 409.41. | |
| FT-1518 | FT-1518 is a new generation selective, potent and oral bioavailable inhibitor of mTORC1 and mTORC2, and it shows antitumor activity. Synonyms: FT1518; NSC-802820. CAS No. 1313026-58-2. Molecular formula: C20H26N8O. Mole weight: 394.48. | |
| FT206 | FT206 is a carboxamide ubiquitin-specific protrase inhibitor. (Extracted from patent WO 2020033707 A1, example 11-1). Synonyms: NSC833745; Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)-1,2,3,4-tetrahydro-2-naphthalenyl]-6-methyl-; 3-Amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)-1,2,3,4-tetrahydro-2-naphthalenyl]-6-methylthieno[2,3-b]pyridine-2-carboxamide. Grade: ≥98%. CAS No. 2278274-34-1. Molecular formula: C25H29N5OS. Mole weight: 447.60. | |
| FT3967385 | FT3967385 is an inhibitor of USP30 that recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Synonyms: FT385; (R)-N-(1-cyanopyrrolidin-3-yl)-3-(2-phenoxyphenyl)-1H-pyrazole-5-carboxamide. Grade: ≥95%. Molecular formula: C21H19N5O2. Mole weight: 373.41. | |
| FT671 | FT671 is a potent and selective USP7 inhibitor with high affinity and specificity in vitro and in cells. FT671 destabilises USP7 substrates including MDM2, elevates p53 and results in transcription of p53 target genes, induction of the tumour suppressor p21, and tumour growth inhibition in mice. Synonyms: FT-671; FT 671; (S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. Grade: >98%. CAS No. 1959551-26-8. Molecular formula: C24H23F4N7O3. Mole weight: 533.48. | |
| FT895 | FT895 is a potent and selective inhibitor of HDAC11 with an IC50 of 3 nM. Synonyms: 1H-Isoindole-4-carboxamide, 2,3-dihydro-N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)-2-pyrazinyl]-; N-Hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)-2-pyrazinyl]-4-isoindolinecarboxamide; 2,3-Dihydro-N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)-2-pyrazinyl]-1H-isoindole-4-carboxamide; HDTK 070; FT-895; FT 895. Grade: ≥95%. CAS No. 2225728-57-2. Molecular formula: C16H15F3N4O2. Mole weight: 352.31. | |
| Ftaxilide | Ftaxilide is an antituberculosis agent used as antiseptic. Synonyms: 2-[(2,6-dimethylphenyl)carbamoyl]benzoic acidFtaxilide2',6'-Dimethylphthalanilic acidHistanorm19368-18-4Ftaxilide [INN:DCF]Ftaxilidum [INN-Latin]Ftaxilida [INN-Spanish]Phthalic 2,6-dimethylanilideUNII-7Z71845H3FMP-12-PMP 12; NSC 16112; MP12; NSC16112; MP-12; NSC-16112Phthalanil. CAS No. 19368-18-4. Molecular formula: C16H15NO3. Mole weight: 269.295. | |
| FTBMT | FTBMT is a novel and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%). FTBMT displays antipsychotic and procognitive properties without causing catalepsy in rodents. Synonyms: 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide. Grade: ≥98% by HPLC. CAS No. 1358575-02-6. Molecular formula: C19H16F4N4O. Mole weight: 392.35. | |
| FTI-2148 | FTI-2148 is a potent farnesyltransferase inhibitor with potential antitumor activity. Synonyms: FTI 2148; FTI2148; (S)-2-(5-((((1H-Imidazol-5-yl)methyl)amino)methyl)-2'-methyl-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoic acid. Grade: 98%. CAS No. 251577-09-0. Molecular formula: C24H28N4O3S. Mole weight: 452.57. | |
| FTI-2153 | FTI-2153 is a potent farnesyltransferase inhibitor. FTI-2153 inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. FTI-2153 was reported to block bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. Synonyms: FTI 2153; FTI2153; (S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}-2''-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid methyl ester. CAS No. 344900-92-1. Molecular formula: C25H30N4O3S. Mole weight: 466.6. | |
| FTI-249 | FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100-200 nM). Synonyms: FTI 249; FTI249; (S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid. Grade: 98%. CAS No. 161721-65-9. Molecular formula: C15H23N3O3S2. Mole weight: 357.49. | |
| FTI-276 | FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene. Synonyms: FTI276; FTI 276; (S)-2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoic acid. CAS No. 170006-72-1. Molecular formula: C21H27N3O3S2. Mole weight: 433.59. | |
| FTI 276 trifluoroacetate salt | FTI 276 is a Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) with > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 = 0.5 and 50 nM, respectively). It exhibits an inhibitory effect on growth of human lung carcinoma expressing oncogenic K-Ras in nude mice. Synonyms: FTI 276 trifluoroacetate salt; FTI276 trifluoroacetate salt; FTI-276 trifluoroacetate salt; N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt. Grade: ≥95% by HPLC. CAS No. 1217471-51-6. Molecular formula: C21H27N3O3S2.C2HF3O2. Mole weight: 547.61. | |
| FTI-277 | FTI-277, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade. Uses: Radiation-sensitizing agents. Synonyms: FTI-277; FTI 277; FTI277. CAS No. 170006-73-2. M | |
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