BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Efavirenz Related Compound B | Efavirenz impurity. Synonyms: (4S)-6-Chloro-4-[(1E)-2-cyclopropylethenyl]-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-Benzoxazin-2-one; USP Efavirenz Related Compound B. Grades: > 95%. CAS No. 440124-96-9. Molecular formula: C14H11ClF3NO2. Mole weight: 317.69. |  |
| Efavirenz Related Compound C | An impurity of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent. Synonyms: 2-Cyclopropyl-6-chloro-4-(trifluoromethyl)quinoline, USP Efavirenz Related Compound C. Grades: > 95%. CAS No. 391860-73-4. Molecular formula: C13H9ClF3N. Mole weight: 271.67. | |
| Efinaconazole Related Impurity 5 | The 2S,3R-enantiomer of Efinaconazole. Synonyms: 1-[[(2S,3S)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole; (2S-trans)-1-[[2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole. Grades: > 95%. CAS No. 135270-10-9. Molecular formula: C12H11F2N3O. Mole weight: 251.23. | |
| Efinaconazole Related Impurity 6 | The 2R,3S-enantiomer of Efinaconazole. Synonyms: 1-[[(2R,3R)-2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole; (2R-trans)-1-[[2-(2,4-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole. Grades: > 95%. CAS No. 135270-13-2. Molecular formula: C12H11F2N3O. Mole weight: 251.23. | |
| Efinaconazole Related Impurity 7 Mesylate | A useful synthetic intermediate in the synthesis of Efinaconazole. Synonyms: (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Methanesulfonate. Grades: > 95%. CAS No. 1175536-50-1. Molecular formula: C12H13F2N3O2. CH4O3S. Mole weight: 365.35. | |
| Eflornithine hydrochloride, hydrate | Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. It is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis. It displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways. It also demonstrates antiparasitic activity in a model of C. parvum infection. Synonyms: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; MDL 71782 hydrochloride hydrate; RMI 71782 hydrochloride hydrate; MDL71782 hydrochloride hydrate; RMI71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate; Vaniqa hydrochloride hydrate. Grades: 98%. CAS No. 96020-91-6. Molecular formula: C6H15ClF2N2O3. Mole weight: 236.64. | |
| eFT-508 | eFT-508 is a selective inhibitor of MNK1/2 (IC50s = 2.4 nM and 1 nM respectively) inhibiting MNK1/2-mediated signaling and the phosphorylation of certain regulatory proteins. It acts against tumor. Synonyms: SCHEMBL17362622; AKOS030627405; ZINC575623807; CS-5841; CS 5841; CS5841; 6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione; eFT508. Grades: 99.83 %. CAS No. 1849590-01-7. Molecular formula: C17H20N6O2. Mole weight: 340.38. | |
| EGF816 | EGF816, also called as Nazartinib, a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M resistance mutation while sparing wild-type EGFR. in vivo: demonstrated strong tumor regressions in several EGFR activating and resistant tumor m. Synonyms: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib; N- [7-chloro -1- [ (3R) -1- [ (E) -4- (di methyl amino) but-2-enoyl ] azepan-3-yl ] benzimidazol-2-yl ] -2- methyl pyridine-4-carboxamide EGF816UNII-KE7K32EME8KE7K32EME8EGF-8161508250-71-2GTPL9204SCHEMBL16767232SCHEMBL16767 240EGF 816compound 47 [PMID: 27433829]. CAS No. 1508250-71-2. Molecular formula: C26H31ClN6O2. Mole weight: 495.02. | |
| Ehp-inhibitor-1 | Ehp-inhibitor-1 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. Study indicated that inhibition of Eph receptors results in an increase in glucose-stimulated insulin secretion from mouse and human pancreatic islets. Synonyms: 6-(3-methoxyphenyl)-3-pyridin-3-ylpyrazolo[1,5-a]pyrimidin-7-amine. CAS No. 861249-59-4. Molecular formula: C18H15N5O. Mole weight: 317.352. | |
| Ehp-inhibitor-2 | Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors. Study indicated that inhibition of Eph receptors results in an increase in glucose-stimulated insulin secretion from mouse and human pancreatic islets. Synonyms: 3-(7-amino-3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol. CAS No. 861249-77-6. Molecular formula: C17H13N5O. Mole weight: 303.325. | |
| EIPA | EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE). Uses: Epithelial sodium channel blockers. Synonyms: Ethylisopropylamiloride; L 593754; MH 12-43; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1154-25-2. Molecular formula: C11H18ClN7O. Mole weight: 299.76. | |
| EIPA hydrochloride | EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE). Synonyms: L593754 hydrochloride; L 593754 hydrochloride; L-593754 hydrochloride; Ethylisopropylamiloride hydrochloride; MH 12-43 hydrochloride; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide hydrochloride. CAS No. 1345839-28-2. Molecular formula: C11H19Cl2N7O. Mole weight: 336.22. | |
| Elacridar | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. | |
| Elacridar hydrochloride | Elacridar is an orally bioavailable inhibitor of P-glycoprotein (P-gp) and ABCG2. Synonyms: Elacridar HCl; N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide hydrochloride. CAS No. 143851-98-3. Molecular formula: C34H33N3O5.HCl. Mole weight: 600.10. | |
| Elafibranor | Elafibranor is a dual PPARα/δ agonist. Elafibranor increases plasma HDL and expression of Acox1, a PPARα target gene, and decreases plasma triglycerides and total cholesterol in the liver of ApoE2-KI wild-type mice. Elafibranor is identified as a drug candidate for the treatment of cardiometabolic diseases such as diabetes, insulin resistance, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). Synonyms: Propanoic acid, 2-[2,6-dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-; 2-[2,6-Dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methylpropanoic acid; (E) -1-[4- (Methylthio) phenyl]-3-[3, 5-dimethyl-4-[ (carboxydimethylmethyl) oxy]phenyl]prop-2-en-1-one; GFT 505; GFT-505; GFT505. Grades: ≥95%. CAS No. 923978-27-2. Molecular formula: C22H24O4S. Mole weight: 384.49. | |
| Elbasvir | Elbasvir has been found to restrain viral phosphoprotein so that could be used against hepatitis C virus and is currently under Phase II trail. Uses: Elbasvir has been found to restrain viral phosphoprotein so that could be used against hepatitis c virus and is currently under phase ii trail. Synonyms: Elbasvir; MK-8742; UNII-632L571YDK; 632L571YDK; MK8742; MK 8742. Grades: 98%. CAS No. 1370468-36-2. Molecular formula: C49H55N9O7. Mole weight: 882.02. | |
| Eldecalcitol Intermediate A | Eldecalcitol Intermediate A is an intermediate of eldecalcitol, a vitamin D3 analogue for the treatment of osteoporosis. Eldecalcitol is more active in bone resorption inhibition in comparison with alfacalcidol. Synonyms: 3-[(1R,2R,4Z,6R)-2,6-bis[[tert-butyl(dimethyl)silyl]oxy]-4-(2-diphenylphosphorylethylidene)-3-methylidenecyclohexyl]oxypropoxy-tert-butyl-dimethylsilane. CAS No. 200636-54-0. Molecular formula: C42H71O5PSi3. Mole weight: 771.254. | |
| Eldecalcitol Intermediate CD | Synonyms: CS-M3125; (1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methyl-6-triethylsilyloxyheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-one. CAS No. 144848-24-8. Molecular formula: C24H46O2Si. Mole weight: 394.715. | |
| Eleclazine | Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart's electrical cycle) in patients with long QT-3 (LQT3) syndrome. Phase III clinical trilas for the treatment of Long QT syndrome, Phase II/III clinical trilas for the treatment of Hypertrophic cardiomyopathy and Phase II clinical trilas for the treatment of Ventricular arrhythmias are on-going. Uses: Long qt syndrome;hypertrophic cardiomyopathy;ventricular arrhythmias. Synonyms: GS-6615; GS 6615; GS6615; Eleclazine. 4-[(pyrimidin-2-yl)methyl]-7-[4-(trifluoromethoxy)phenyl]- 3,4-dihydro-1,4-benzoxazepin-5(2H)-one. Grades: 98%. CAS No. 1443211-72-0. Molecular formula: C21H16F3N3O3. Mole weight: 415.37. | |
| Eletriptan HBr | Eletriptan induces concentration-dependent contractions of meningeal artery, coronary artery, and saphenous vein. The potency of Eletriptan is higher in meningeal artery than in coronary artery (86-fold) or saphenous vein (66-fold). Synonyms: Eletriptan Hydrobromide; CHEBI:61176; M41W832TA3; UNII-M41W832TA3; eletriptan hydrobromide; Relpax; UK 166,044; UK 166044; UK-166,044; UK-166044. Grades: >98%. CAS No. 177834-92-3. Molecular formula: C22H26N2O2S.HBr. Mole weight: 463.43. | |
| Eletriptan N-oxide | An impurity of Eletriptan. Synonyms: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole N Oxide. Grades: > 95%. CAS No. 1217641-89-8. Molecular formula: C22H26N2O3S. Mole weight: 398.53. | |
| ELOVL1-IN-2 | ELOVL1-IN-2 is an inhibitor of ELOVL1 (elongation of very-long-chain-fatty acid 1). CAS No. 2761063-79-8. Molecular formula: C18H15FN2O. Mole weight: 294.3. | |
| Eltoprazine hydrochloride | Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine hydrochloride has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride;DU-28853 hydrochloride;DU28853 hydrochloride. Grades: >98 %. CAS No. 98206-09-8. Molecular formula: C12H17N2O2Cl. Mole weight: 256.73. | |
| Eltrombopag | Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). Uses: Nonpeptide thrombopoietin receptor agonist. Synonyms: SB-497115-GR, SB497115. Grades: >98%. CAS No. 496775-61-2. Molecular formula: C25H22N4O4. Mole weight: 442.47. | |
| Eltrombopag Methyl Ester | Eltrombopag Methyl Ester is a metabolite of Eltrombopag. Synonyms: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic Acid Methyl Ester. Grades: > 95%. CAS No. 1246929-01-0. Molecular formula: C26H24N4O4. Mole weight: 456.49. | |
| Eltrombopag Olamine | Eltrombopag is a is an agonist of the c-mpl (TpoR) receptor used as treatment for thrombocytopenia.It has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts). Uses: C-mpl agonist. Synonyms: SB-497115-GR; 2-mainoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate). Grades: ≥98%. CAS No. 496775-62-3. Molecular formula: C29H36N6O6. Mole weight: 564.64. | |
| Eluxadoline Related Compound 1 | Eluxadoline impurity. Synonyms: (S)-Methyl 2-Methoxy-5-((1-(4-phenyl-1H-imidazol-2-yl)ethylamino)methyl)benzoate. Grades: > 95%. CAS No. 1391712-57-4. Molecular formula: C20H21N3O3. Mole weight: 351.41. | |
| Elvitegravir | Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI) for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Uses: Anti-retroviral agents. Synonyms: GS-9137; GS 9137; GS9137; JTK-303; JTK 303; JTK303; EVG; D06677; D 06677; D-06677. Grades: ≥98%. CAS No. 697761-98-1. Molecular formula: C23H23ClFNO5. Mole weight: 447.88. | |
| Emamectin | Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation property. Synonyms: (4''R)-4''-Deoxy-4''-(methylamino)avermectin B1; emamectin B1a. CAS No. 119791-41-2. Molecular formula: C49H75NO13. Mole weight: 886.133. | |
| Emamectin Benzoate | Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation properties. Uses: Antiparasitic agents. Synonyms: Proclaim; Proclaim 5SG; Denim; Methylamino abamectin benzoate; Shot Wan; Denim (pesticide); Sch 58854; MK 244. Grades: > 95%. CAS No. 155569-91-8. Molecular formula: C56H81NO15. Mole weight: 1008.24. | |
| Emapunil | Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects. Synonyms: AC-5216; AC 5216; AC5216; XBD-173; XBD 173; XBD173; Emapunil. Grades: >98%. CAS No. 226954-04-7. Molecular formula: C23H23N5O2. Mole weight: 401.46. | |
| EMD638683 | EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 μM. Synonyms: EMD638683; EMD 638683; EMD-638683. Grades: >98%. CAS No. 1181770-72-8. Molecular formula: C18H18F2N2O4. Mole weight: 364.34. | |
| Emedastine Difumarate | Emedastine is a H1 receptor antagonist. It is a second generation antihistamine. Emedastine can block the action of histamine that causes allergic symptoms. It can be used in eye drops to alleviate the symptoms of allergic conjunctivitis. Uses: Allergic conjunctivitis; allergic rhinitis; atopic dermatitis; dermatitis; urticaria. Synonyms: Emedastine fumarate; Rapimine; AL-3432A; DSSTox_CID_26911; KB 2413; KB-2413; KG 2413; KG-2413; Emadine; 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole Difumarat. Grades: 95%. CAS No. 87233-62-3. Molecular formula: C25H34N4O9. Mole weight: 534.56. | |
| Emopamil | Emopamil is a calcium channel blocker that can be used to prevent renal injury after warm & cold ischemia. Uses: Calcium channel blockers. Synonyms: Emopamil; 78370-13-5; Emopamil [INN]; Emopamilum [Latin]; Emopamilo [Spanish]. Grades: 95%. CAS No. 78370-13-5. Molecular formula: C23H30N2. Mole weight: 334.504. | |
| Empagliflozin Methyl Acetate | Empagliflozin Methyl Acetate is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: ((2R,3S,4R,5R,6S)-6-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl Acetate. CAS No. 2452301-09-4. Molecular formula: C25H29ClO8. Mole weight: 492.95. | |
| Empagliflozin Ortho Isomer | Empagliflozin Ortho Isomer is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (2S,3R,4R,5S,6R)-2-(4-chloro-3-(2-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 2452301-30-1. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| Empagliflozin Tetraacetoxy | Empagliflozin Tetraacetoxy is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl Triacetate. CAS No. 1620758-21-5. Molecular formula: C32H37ClO12. Mole weight: 649.08. | |
| Emraclidine | Emraclidine is a muscarinic M4 receptor positive allosteric modulator. Synonyms: 1-(2,4-dimethyl-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-{1-[2-(trifluoromethyl)pyridin-4-yl]azetidin-3-yl}ethan-1-one. CAS No. 2170722-84-4. Molecular formula: C20H21F3N4O. Mole weight: 390.41. | |
| Emtricitabine Carboxylic Acid | Emtricitabine Carboxylic Acid is an impurity of the antiviral agent Emtricitabine. Synonyms: (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid. Grades: > 95%. CAS No. 1238210-10-0. Molecular formula: C8H8FN3O4S. Mole weight: 261.23. | |
| Emtricitabine Diphosphate Triethylammonium Salt | Emtricitabine Diphosphate Triethylammonium Salt is a metabolite of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: (2R-cis)-Mono[[5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] Ester Diphosphoric Acid Triethylammonium Salt; 1,3-Oxathiolane, Diphosphoric Acid Deriv. Triethylammonium Salt. Grades: 90%. Molecular formula: C8H12FN3O9P2S.xC6H15N. Mole weight: 407.21 (free acid). | |
| Emtricitabine Enantiomer | A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Synonyms: 4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; (2S-cis)-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone. Grades: > 95%. CAS No. 137530-41-7. Molecular formula: C8H10FN3O3S. Mole weight: 247.25. | |
| Emtricitabine impurity (2,3'-dideoxy-5-fluoro-3-thiouridine) | Impurity in commercial preparations of Emtricitabine. Synonyms: 5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidine-2,4(1H,3H)-dione. Grades: > 95%. CAS No. 145281-92-1. Molecular formula: C8H9FN2O4S. Mole weight: 248.23. | |
| Emtricitabine Isopropyl Carbamate | Emtricitabine Isopropyl Carbamate is a derivative of Emtricitabine.Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: Isopropyl (5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. Grades: > 95%. Molecular formula: C12H16FN3O5S. Mole weight: 333.34. | |
| Emtricitabine Related Impurity 1 | An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: 5-fluoro-1-[(2R,?5S)?-2-(hydroxymethyl)?-1,?3-oxathiolan-5-yl]?-, rel- 2,?4(1H,?3H)?-Pyrimidinedione. Grades: > 95%. CAS No. 3790-05-0. Molecular formula: C8H9FN2O4S. Mole weight: 248.23. | |
| Emtricitabine Related Impurity 2 | An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: 4-amino-5-fluoro-1-[(2R,?4R)?-2-(hydroxymethyl)?-1,?3-dioxolan-4-yl]?-2(1H)?-Pyrimidinone. Grades: > 95%. CAS No. 145417-33-0. Molecular formula: C8H10FN3O4. Mole weight: 231.19. | |
| Emtricitabine Related Impurity 3 | An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: 4-amino-5-fluoro-1-[(2R,?4R)?-2-carboxylic acid-1,?3-dioxolan-4-yl]?-2(1H)?-Pyrimidinone. Grades: > 95%. Molecular formula: C8H8FN3O5. Mole weight: 245.17. | |
| Emtricitabine Related Impurity 4 | An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: (3R,6R,10R,10aS)-7-amino-10-fluoro-2,3,6,6a,10,10a-hexahydro-3,6-epoxy[1,4]oxathiocino[7,8-c]pyridin-9(5H)-one. Grades: > 95%. Molecular formula: C9H11FN2O3S. Mole weight: 246.26. | |
| Emtricitabine Related Impurity 5 | An impurity of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: (3R,6R,10R,10aS)-10-fluorohexahydro-3,6-epoxy[1,4]oxathiocino[7,8-c]pyridine-7,9(5H,8H)-dione. Grades: > 95%. Molecular formula: C9H11FN2O3S. Mole weight: 246.26. | |
| Emtricitabine S-Oxide | A metabolite of Emtricitabine. Synonyms: 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; [2R-(2α,5α)]-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-Oxide; [2R-(2α,5α)]-4-Amino-5-fluoro-1-[2-(hydroxymethyl)-3-oxido-1. Grades: > 95%. CAS No. 152128-77-3. Molecular formula: C8H10FN3O4S. Mole weight: 263.25. | |
| Emtricitabine Tenofovir Disoproxil Dimer | Emtricitabine Tenofovir Disoproxil Dimer is a derivative of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: ( ( ( ( ( (R)-1- (6- ( ( ( (5-Fluoro-1- ( (2R, 5S)-2- (hydroxymethyl)-1, 3-oxathiolan-5-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis (oxy))bis (methylene) Diisopropyl Dicarbonate. Grades: > 95%. Molecular formula: C28H40FN8O13PS. Mole weight: 778.71. | |
| Emtricitabine Tenofovir Monosoproxil Dimer | Emtricitabine Tenofovir Monosoproxil Dimer is a derivative of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: ( ( ( ( ( (R)-1- (6- ( ( ( (5-Fluoro-1- ( (2R, 5S)-2- (hydroxymethyl)-1, 3-oxathiolan-5-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl) (hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate. Grades: > 95%. Molecular formula: C23H32FN8O10PS. Mole weight: 662.60. | |
| Emtricitabine Thioacetate | Emtricitabine Thioacetate is synthesized from emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: S-(((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl) Ethanethioate. Grades: > 95%. Molecular formula: C10H12FN3O3S2. Mole weight: 305.35. | |
| (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: Afatinib Impurity L. Grades: ≥95%. CAS No. 2223677-61-8. Molecular formula: C20H19ClFN5O2. Mole weight: 415.85. | |
| Enalaprilat Dihydrate | Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor. Grades: >98%. CAS No. 84680-54-6. Molecular formula: C18H28N2O7. Mole weight: 384.42. | |
| Enasidenib | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Synonyms: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib. Grades: 98%. CAS No. 1446502-11-9. Molecular formula: C19H17F6N7O. Mole weight: 473.38. | |
| Endo-3-D-Pal-Cetrorelix | Endo-3-D-Pal-Cetrorelix is an impurity of Cetrorelix, which is a gonadotropin-releasing hormone antagonist used in the treatment of prostate and breast cancers. Synonyms: Ac-D-2Nal-D-Phe(4-Cl)-D-3-Pal-D-3-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide. Molecular formula: C78H100ClN19O15. Mole weight: 1579.23. | |
| Endo-Gly-AVP | Endo-Gly-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: Endo-Gly-Vasopressin; Vasopressin, 8-L-arginine-8a-endo-glycine-; H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-Gly-NH2 (Disulfide bridge: Cys1-Cys6); L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginylglycyl-glycinamide (1->6)-disulfide. CAS No. 77403-94-2. Molecular formula: C48H68N16O13S2. Mole weight: 1141.29. | |
| Endothelin 1 (swine, human) | Endothelin 1 (swine, human), a vasoconstrictor increased in plasma and explants of patients with uterine leiomyomas, is a synthetic peptide with the sequence of human and swine Endothelin 1 and acts through two types of receptors ETA and ETB. Synonyms: Endothelin 1 swine, human; Endothelin 1; L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide); H-Cys(1)-Ser-Cys(2)-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys(2)-Val-Tyr-Phe-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH. Grades: 95%. CAS No. 117399-94-7. Molecular formula: C109H159N25O32S5. Mole weight: 2491.9. | |
| Endothelin-3, human, mouse, rabbit, rat | Endothelin 3 is a ligand of the endothelin (ET) receptors and a potent vasoconstrictor. Endothelin 3 increases blood pressure in spontaneously hypertensive and normotensive rats, and promotes migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Uses: Vasoconstrictor. Synonyms: Endothelin 3 (Rat,Human); ET-3 (Rat,Human); H-Cys(1)-Thr-Cys(2)-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys(2)-Val-Tyr-Tyr-Cys(1)-His-Leu-Asp-Ile-Ile-Trp-OH; L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan (1->15),(3->11)-bis(disulfide). Grades: ≥97% by HPLC. CAS No. 117399-93-6. Molecular formula: C121H168N26O33S4. Mole weight: 2643.04. | |
| Enfuvirtide | Enfuvirtide is a biomimetic peptide of HIV-1 fusion inhibitor with CD4+ cells and it is used to patients with multi-drug resistant HIV. Enfuvirtide binds to gp41 preventing the creation of an entry pore for the HIV-1 virus. Synonyms: N-Acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-asparaginyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparaginyl-L-tryptophyl-L-phenylalaninamide; DP 178; ENF; Fuzeon; GP 41-127-162AA; Pentafuside; T 20; T 20 (peptide); Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2. Grades: ≥98%. CAS No. 159519-65-0. Molecular formula: C204H301N51O64. Mole weight: 4491.88. | |
| ENMD-2076 | ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers. ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid tumor cancers, leukemia, and multiple myeloma. ENMD-2076 is currently in a Phase 2 trial for ovarian cancer, and preclinical and clinical activities are ongoing in assessing the compound's applicability for other forms of cancer. Synonyms: ENMD-2076; ENMD 2076; ENMD2076. CAS No. 934353-76-1. Molecular formula: C21H25N7. Mole weight: 375.47. | |
| ent-9-Desmethyl-alpha-Dihydro-Tetrabenazine | Ent-9-Desmethyl-alpha-Dihydro-Tetrabenazine is one of Tetrabenazine derivatives. Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. It is a monoamine-depleting and a dopamine-receptor-blocking drug and is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. Synonyms: (-)-9-O-Desmethyl-alpha-dihydrotetrabenazine; (2S,3R,11bS)-10-Methoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2,9-diol; (-)-9-deMe-DTBZ; 3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2,9-diol. Grades: ≥95%. CAS No. 1065193-41-0. Molecular formula: C18H27NO3. Mole weight: 305.41. | |
| Entacapone | Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) (IC50 = 151 nM), commonly used in combination with other medications for the treatment of Parkinson's disease. Synonyms: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-; Comtan; HSDB 8251; HSDB-8251; HSDB8251; OR-611; OR 611; OR611; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-; (E)-Entacapone; Comtess; Entacom; Parkicapone. Grades: >98%. CAS No. 130929-57-6. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| Ent-α-C Dapagliflozin | Ent-α-C Dapagliflozin is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2S,3S,4S,5R,6S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grades: >95%. Molecular formula: C21H25ClO6. Mole weight: 408.87. | |
| Ent-Galantamine | Ent-Galantamine is the (+) enantiomer of Galanthamine and acts as a selective inhibitor of acetylcholinesterase(AChE). Synonyms: Galantamine Impurity F; (4aR,6S,8aR)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol; (+)-Galanthamine. Grades: > 95%. CAS No. 60384-53-4. Molecular formula: C17H21NO3. Mole weight: 287.36. | |
| ent-Oseltamivir Phosphate | ent-Oseltamivir Phosphate is the enatiomer of Oseltamivir Phosphate, which is a prodrug of the influenza neuraminidase inhibitor Oseltamivir. Synonyms: (3S,4S,5R)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate; 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3S,4S,5R)-, phosphate (1:1); (3S,4S,5R)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate phosphate. Grades: ≥95%. CAS No. 1035895-89-6. Molecular formula: C16H31N2O8P. Mole weight: 410.40. | |
| Entrectinib | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2. Uses: Protein kinase inhibitors. Synonyms: RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628; Entrectinib; N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. Grades: ≥98%. CAS No. 1108743-60-7. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. | |
| Enviroxime | Enviroxime is a benzimidazole derivative that inhibits the replication of rhinoviruses and poliovirus by targeting protein 3A. Enviroxime exhibits antiviral effects against EV71 with EC50 of 0.15 μM. Uses: Coxsackievirus infections; picornavirus infections. Synonyms: (1E)-[2-Amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]phenylmethanone Oxime; 6-[(E)-(Hydroxyimino)phenylmethyl]-1-[(1-methylethyl)sulfonyl]- 1H-Benzimidazol-2-amine; LY 122772; LY122772; LY-122772. Grades: 98%. CAS No. 72301-79-2. Molecular formula: C17H18N4O3S. Mole weight: 358.41. | |
| (E)-Olopatadine | (E)-Olopatadine is an isomer of Olopatadine, a histamine blocker and mast cell stabilizer. Synonyms: Olopatadine, (E)-; Olopatadine (E)-Isomer. CAS No. 113806-06-7. Molecular formula: C21H23NO3. Mole weight: 337.4. | |
| (E)-Olopatadine Hydrochloride | (E)-Olopatadine Hydrochloride is an impurity of Olopatadine, a histamine blocker and mast cell stabilizer. Synonyms: 2-[(11E)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]ethanoic acid hydrochloride; Olopatadine (E)-Isomer. CAS No. 949141-22-4. Molecular formula: C21H24ClNO3. Mole weight: 373.9. | |
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