BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Fosteabine | Fosteabine is an oral and prodrug cytarabine analogue. It is resistant to deoxycytidine deaminase. Synonyms: Cytarabine ocfosfate; Stearyl-ara-cmp; YNK 01; YNK-01; YNK01. CAS No. 73532-83-9. Molecular formula: C27H50N3O8P. Mole weight: 575.68. |  |
| Fostriecin sodium salt | Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect on topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM). Fostriecin is found in Streptomyces pulveraceous. Uses: Enzyme inhibitors. Synonyms: Fostriecin Sodium; Antibiotic CI 920 sodium salt; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt. Grade: ≥98% by HPLC. CAS No. 87860-39-7. Molecular formula: C19H26O9PNa. Mole weight: 452.37. | |
| Fostroxacitabine Bralpamide | Fostroxacitabine Bralpamide is an antineoplastic drug. Synonyms: (2S)-pentan-2-yl N-[(S)-{[(2S,4S)-4-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-dioxolan-2-yl]methoxy}(4-bromophenoxy)phos-phoryl]-L-alaninate; L-Alanine, N-((((2S,4S)-4-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-dioxolan-2-yl)methoxy)(4-bromophenoxy)phosphinyl)-, (1S)-1-methylbutyl ester; (S)-pentan-2-yl ((S)-(((2S,4S)-4-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-dioxolan-2-yl)methoxy)(4-bromophenoxy)phosphoryl)-L-alaninate; MIV-818; MIV818; MIV 818; Troxacitabine nucleotide prodrug MIV-818. CAS No. 2129993-56-0. Molecular formula: C22H30BrN4O8P. Mole weight: 589.38. | |
| Fotemustine | Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. Synonyms: Muphoran, S 10036. Grade: >98%. CAS No. 92118-27-9. Molecular formula: C9H19ClN3O5P. Mole weight: 315.691. | |
| FOXO4-DRI | FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. FOXO4-DRI is a standard FOXO4 protein that is synthesized to prevent normal FOXO4 from binding to p53, thereby eliminating senescent cells and improving organ function and the ''biological age'' of young tissues. FOXO4-DRI affects a variety of cellular processes, including insulin signaling, cell cycle regulation, and oxidative stress signaling pathways, it is a cell-penetrative peptide, meaning it can enter cells from the inside and perform its role, and it has been shown in animal studies to selectively induce apoptosis in senescence cells, potentially reversing some of the effects of aging. Synonyms: FOXO 4-DRI; Anti-aging peptide FOXO4-DRI; H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH; Forkhead box O transcription factor 4-D-Retro-Inverso; Proxofim; D-Retro Inv. Grade: 95%. CAS No. 2460055-10-9. Molecular for | |
| FOY 251 | FOY 251 is a metabolite of camostat mesilate, and a proteinase inhibitor. Synonyms: Foy 251; 71079-09-9; 4-(4-Guanidinobenzoyloxy)phenylacetic acid; FOY-251 mesylate; FOY251; 4-GBCE (methanesulfonate); 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt; 2-[4-[4-(diaminomethylideneamino)benzoyl]oxyphenyl]acetic acid; methanesulfonic acid; CHEMBL433135; FOY-251 mesylate?; 4-[[4-[(AMINOIMINOMETHYL)AMINO]BENZOYL]OXY]-BENZENEACETIC ACID MONOMETHANESULFONATE; SCHEMBL1649708; SCHEMBL11417275; DTXSID20991365; EX-A5589; HY-19727A; MFCD09842546; s3511; AKOS030614588; CS-0016501; EN300-7455534; 4-(4-Guanidinobenzoyloxy)-phenylacetic acid x Methanesulfonic acid; 2-[4-(4-carbamimidamidobenzoyloxy)phenyl]acetic acid; methanesulfonic acid; [4-(4-CARBAMIMIDAMIDOBENZOYLOXY)PHENYL]ACETIC ACID; METHANESULFONIC ACID; {4-[(4-Carbamimidamidobenzoyl)oxy]phenyl}acetic acid--methanesulfonic acid (1/1); 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid compound with methanesulfonic acid (1:1); 2-(4-((4-guanidinobenzoyl)oxy)phenyl)acetic acid--methanesulfonic acid (1/1); Benzeneacetic acid, 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-, monomethanesulfonate. CAS No. 71079-09-9. Molecular formula: C9H10BrFN2O5. Mole weight: 325.09. | |
| Fozivudine tidoxil | Fozivudine tidoxil, an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity, is a reverse transcriptase inhibitor potentially for the treatment of HIV infection. Fozivudine tidoxil, a member of the NRTI family, is incorporated into the newly synthesized DNA strand during intracellular viral replication and irreversibly binds to the viral RT, thereby disrupting the reverse transcription of the virus. Synonyms: BM-211290; Fozivudine; 3'-Azido-3'-deoxy-5'-thymidylic Acid Mono(2-(decyloxy)-3-(dodecylthio)propyl) Ester; 3'-Azido-5'-O-{[2-(decyloxy)-3-(dodecylsulfanyl)propoxy](hydroxy)phosphoryl}-3'-deoxythymidine; 5'-Thymidylic acid, 3'-azido-3'-deoxy-, mono(2-(decyloxy)-3-(dodecylthio)propyl) ester. Grade: ≥95%. CAS No. 141790-23-0. Molecular formula: C35H64N5O8PS. Mole weight: 745.95. | |
| FPA 124 | FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Synonyms: FPA 124; FPA124; FPA-124; Akt Inhibitor XI; Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex. CAS No. 902779-59-3. Molecular formula: C11H9Cl2CuN3O2S. Mole weight: 381.73. | |
| FPFT-2216 | FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), Ikaros (IKZF1) and Aiolos (IKZF3) zinc finger transcription factors, and casein kinase 1α (CK1α). Synonyms: 2,6-Piperidinedione, 3-[4-(4-methoxy-3-thienyl)-1H-1,2,3-triazol-1-yl]-. CAS No. 2367619-87-0. Molecular formula: C12H12N4O3S. Mole weight: 292.31. | |
| FPH1 | FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes. Synonyms: FPH 1; FPH-1; 2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide. Grade: >98%. CAS No. 708219-39-0. Molecular formula: C16H15ClF2N2O3S. Mole weight: 388.82. | |
| FPH2 | FPH2 is a small molecule, which promotes differentiation of iPS-derived hepatocytes. Synonyms: BRD-9424; BRD9424; BRD 9424; FPH2; FPH 2; FPH-2. Grade: >98%. CAS No. 957485-64-2. Molecular formula: C14H16ClN5O2S. Mole weight: 353.83. | |
| FPI-1523 | FPI-1523 is a potent β-lactamase inhibitor with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. CAS No. 1452459-50-5. Molecular formula: C9H14N4O7S. Mole weight: 322.30. | |
| FPI-1523 sodium | FPI-1523 is a potent β-lactamase inhibitor with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. CAS No. 1452459-52-7. Molecular formula: C9H13N4NaO7S. Mole weight: 344.28. | |
| FPI-1602 | FPI-1602 is a β-lactamase inhibitor and shows marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp. CAS No. 1452460-31-9. Molecular formula: C11H17N5O7S. Mole weight: 363.35. | |
| FPL 55712 | FPL 55712 is a leukotriene receptor antagonist that inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4. Synonyms: FPL 55712; FPL55712; FPL-55712; 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid. Grade: ≥97% by HPLC. CAS No. 40785-97-5. Molecular formula: C27H30O9. Mole weight: 498.52. | |
| FPL 62064 | FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX). FPL 62064 exhibits anti-inflammatory activity. Synonyms: 1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl-; N-(4-methoxyphenyl)-1-phenyl-1H-Pyrazol-3-amine. Grade: 95%. CAS No. 103141-09-9. Molecular formula: C16H15N3O. Mole weight: 265.31. | |
| FPL 64176 | FPL 64176 is a potent L-type Ca2+ channel activator (EC50 = 16 nM) displaying 40-fold potency against Bay K 8644 as a positive inotrope in guinea pig atria. Uses: Calcium channel agonists. Synonyms: FPL-64176; FPL 64176; FPL64176; 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester; Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate. Grade: ≥99% by HPLC. CAS No. 120934-96-5. Molecular formula: C22H21NO3. Mole weight: 347.41. | |
| FPPQ | FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist that exhibits antipsychotic and procognitive properties. CAS No. 1648745-46-3. Molecular formula: C21H19FN4O2S. Mole weight: 410.46. | |
| FPPS-IN-11 | FPPS-IN-11 is a novel allosteric non-bisphosphonate inhibitor of farnesyl pyrophosphate synthase (FPPS). Synonyms: 1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid. Grade: >98%. CAS No. 1250273-31-4. Molecular formula: C15H11NO4. Mole weight: 269.25. | |
| FPR A14 | FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 = 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization, respectively). Synonyms: AG 14; AG14; AG-14; 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide. Grade: ≥99% by HPLC. CAS No. 329691-12-5. Molecular formula: C23H20N2O5. Mole weight: 404.42. | |
| FPS-ZM1 | FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. It binds exclusively to RAGE and inhibits β-secretase activity and Aβ production. It also suppresses microglia activation and the neuroinflammatory response in brain. It penetrates the blood-brain barrier and binds to RAGE, thus reducing the protein levels of various cytokines. It inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. It is not toxic to mice and can easily cross the blood-brain barrier in vivo. It might be a novel therapeutic agent to treat AD patients. Uses: Fps-zm1 might be a novel therapeutic agent to treat ad patients. Synonyms: FPS-ZM1; FPS ZM1; FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1; N-benzyl-4-chloro-N-cyclohexylbenzaMide; 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide. Grade: >98 %. CAS No. 945714-67-0. Molecular formula: C20H22ClNO. Mole weight: 327.85. | |
| FPTQ | FPTQ is a potent mGluR1 antagonist and has anti-oxidant and anti-inflammatory effects in vitro and in vivo. Synonyms: 6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl)quinoline. Grade: 99%. CAS No. 864863-72-9. Molecular formula: C17H12FN5. Mole weight: 305.31. | |
| FQI 1 | FQI 1 is a cell-permeable and reversible inhibitor of α-globin transcription factor CP2 (LSF; IC50 = 2.1 μM) and an antiproliferative. FQI 1 induces apoptosis in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 acts via inhibiting LSF-DNA binding. Uses: Antiproliferative. Synonyms: FQI 1; FQI1; FQI-1; 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one; 8-(2-Ethoxy-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one. Grade: 99%. CAS No. 599151-35-6. Molecular formula: C18H17NO4. Mole weight: 311.33. | |
| FR 110302 | This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma in Japan. Synonyms: FR 110302; FR110302; FR-110302. 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-1-Naphthalenol. Grade: 98%. CAS No. 119256-94-9. Molecular formula: C28H35NO2. Mole weight: 417.58. | |
| FR 113680 | FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity originated by Fujisawa for the treatment of Asthma. But no development are reported yet. Uses: Asthma. Synonyms: FR 113680; FR113680; FR-113680; Ac-Thr-trp(cho)-phe-N-mebzl. Ac-Thr-trp(cho)-phe-N-mebzl; N-acetyl-L-threonyl-1-formyl-D-tryptophyl-N-methyl-N-(phenylmethyl)-L-Phenylalaninamide. Grade: 98%. CAS No. 126088-92-4. Molecular formula: C35H39N5O6. Mole weight: 625.72. | |
| FR 121196 | FR 121196 is a potential antidementia drug originated by Fujisawa. Mechanism of Action is not undefined. FR 121196 can ameliorate the impaired memory of rat in the Morris water maze. No development was reported for Cognition disorders in Japan. Uses: Cognition disorders. Synonyms: FR 121196; FR 121196; FR 121196. N-(4-acetylpiperazin-1-yl)-4-fluorobenzenesulfonamide. Grade: 98%. CAS No. 133920-65-7. Molecular formula: C12H16FN3O3S. Mole weight: 301.34. | |
| FR 122047 hydrochloride | FR-122047 is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 values is 0.028μM for COX-1 and 65 μM for COX-2. FR-122047 displays 2300 fold greater selectivity towards inhibition of COX-1 over COX-2. It shows analgesic, anti-platelet and anti-inflammatory properties. No development was reported for the treatment of Pain, Rheumatoid arthritis and Thrombosis. Uses: Pain; rheumatoid arthritis; thrombosis. Synonyms: FR 122047 hydrochloride; 1-[[4,5-bis-(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride. Grade: >98 %. CAS No. 130717-51-0. Molecular formula: C23H25N3O3S.HCl. Mole weight: 459.99. | |
| FR122047 hydrochloride hydrate | FR122047 is a selective inhibitor of COX-1 with an IC50 value of 0.028 μM. Synonyms: 1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine, monohydrochloride, monohydrate. Grade: ≥98%. Molecular formula: C23H25N3O3S·HCl·H2O. Mole weight: 478. | |
| FR 139317 | FR 139317 is a selective Endothelin A receptor antagonist originated by Fujisawa. (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). No development was reported for the treatment of Cerebrovascular disorders, Coronary disorders, Diabetic nephropathies, Heart failure, Hypertension, Ischaemic heart disorders, Myocardial infarction and Renal failure. Uses: Cerebrovascular disorders; coronary disorders; diabetic nephropathies; heart failure; hypertension; ischaemic heart disorders; myocardial infarction; renal failure. Synonyms: FR 139317; FR139317; FR139317; PD 147953; PD147953; PD-147953; 2-((1-(Hexahydro-1H-azepinyl)carbonyl)amino-4-methylpentanoyl)-3-(-(1-methyl-1H-indolyl)propionyl)amino-3-(2-pyridyl)propionic acid. Grade: 98 %. CAS No. 142375-60-8. Molecular formula: C33H44N6O5. Mole weight: 604.75. | |
| FR-167356 | FR-167356, a benzofuran derivative, has been found to be an acuolar ATPase inhibitor and could probablye be useful in studies of some lytic bone diseases. Synonyms: FR-167356; FR167356; FR 167356; UNII-XF02B1HC8R. DSSTox_CID_28148; DSSTox_RID_82712; 2,6-dichloro-N-[3-(2-hydroxypropan-2-yl)-2-methyl-1-benzofuran-7-yl]benzamide. Grade: 98%. CAS No. 174185-16-1. Molecular formula: C19H17Cl2NO3. Mole weight: 378.25. | |
| FR-167653 | FR-167653 is a p38 mitogen-activated protein kinase inhibitor, which suppresses the development of endometriosis in a murine model. FR-167653 meliorates murine bleomycin-induced pulmonary fibrosis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: FR-167653; FR 167653; FR167653. CAS No. 158876-66-5. Molecular formula: C24H20FN5O6S. Mole weight: 525.51. | |
| FR-167653 Free base | FR-167653, a pyrazolo?triazin derivative, has been found to be a cytokine inhibitor as well as P38 mitogen-activated protein kinase inhibitor and was once studied as an anticoagulant. Synonyms: FR167653; FR-167653; FR 167653; 1,?2-Ethanedione, 1-[7-(4-fluorophenyl)?-3,?4-dihydro-8-(4-pyridinyl)?pyrazolo[5,?1-c]?[1,?2,?4]?triazin-2(1H)?-yl]?-2-phenyl-. Grade: 98%. CAS No. 158876-65-4. Molecular formula: C24H18FN5O2. Mole weight: 427.43. | |
| FR-168888 | FR-168888, a guanidine compound, has been found to be a sodium hydrogen antiporter inhibitor that was once studied in myocardial ischaemia therapy. Synonyms: FR-168888; FR 168888; FR168888; Benzamide, N-(aminoiminomethyl)-3-(hydroxymethyl)-5-(1H-pyrrol-1-yl)-, methanesulfonate (1:1). Grade: 98%. CAS No. 168620-46-0. Molecular formula: C14H18N4O5S. Mole weight: 354.38. | |
| FR-168888 Free Base | The free base of FR-168888, a guanidine compound, has been found to be a sodium hydrogen antiporter inhibitor that was once studied in myocardial ischaemia therapy. Synonyms: FR-168888 free base; FR 168888 free base; FR168888 free base; SCHEMBL1388039; SCHEMBL8300855; Benzamide, N-(aminoiminomethyl)-3-(hydroxymethyl)-5-(1H-pyrrol-1-yl)-. Grade: 98%. CAS No. 168620-45-9. Molecular formula: C13H14N4O2. Mole weight: 258.28. | |
| FR 171113 | FR 171113 is a protease-activated receptor 1 (PAR1) antagonist displaying significant antiplatelet activity in vitro. It inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time. Synonyms: FR 171113; FR171113; FR-171113; 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester. Grade: ≥98% by HPLC. CAS No. 173904-50-2. Molecular formula: C19H11Cl3N2O4S. Mole weight: 469.73. | |
| FR 180204 | FR180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.FR180204 showed activity to inhibit ERKs (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Synonyms: 865362-74-9; FR 180204; FR-180204; ERK inhibitor II; 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE; 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine; 4C7X7GV82C; CHEMBL259551; 1H-Pyrazolo(3,4-C)pyridazin-3-amine, 5-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-; 5-(2-Phenylpyrazolo(1,5-a)pyridin-3-yl)-2H-pyrazolo(3,4-C)pyridazin-3-amine; 5-{2-phenyl. Grade: 0.98. CAS No. 865362-74-9. Molecular formula: C9H11N5O4. Mole weight: 253.22. | |
| FR-181074 | FR-181074 may be a bio-active chemical to treat Male Sexual Dysfunction. Synonyms: 1-[(2-chlorophenyl)methyl]-3-(2-methylpropanoyl)-2-propylindole-6-carboxamide; FR-181074; FR181074; FR 181074; UNII-D3C5RV093V. Grade: >98%. CAS No. 184147-65-7. Molecular formula: C23H25ClN2O2. Mole weight: 396.91. | |
| FR-181157 | FR-181157, an oxazol derivative, has been found to be a prostaglandin mimetic and could have potential biological activities as a IP receptor agonist. Synonyms: FR-181157; FR 181157; FR181157; FR-181157 Free Base. (S)-FR-181157; SCHEMBL8057380; sodium; 2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate. Grade: 98%. CAS No. 171046-15-4. Molecular formula: C30H26NNaO4. Mole weight: 487.52. | |
| FR-181157 Free base | FR-181157 is an orally active prostacyclin mimetic that shows high potency and agonist efficacy at the IP receptor. Synonyms: sodium; 2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate; FR 181157; FR181157; 200433-03-0 (FR-181157 Free Base). Grade: >98%. CAS No. 200433-03-0. Molecular formula: C30H26NNaO4. Mole weight: 487.52. | |
| FR-181877 | FR-181877, an oxopyridazin derivative, has been found to be a nonprostanoid PGI2 agonist and could restrain the aggregation of human platelets induced by ADP. IC50: 0.081μM. Synonyms: FR-181877; FR 181877; FR181877. (-)-FR-181877; 2-[[(6S)-6-[(3-benzhydryl-6-oxopyridazin-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetic acid. Grade: 98%. CAS No. 172936-99-1. Molecular formula: C30H28N2O4. Mole weight: 480.56. | |
| FR-182024 | FR-182024, an azabicyclo derivative, has been found to have potential activity as an anti-Helicobacter pylori agent and was once stuied against helicobacter infections. Synonyms: FR-182024; FR 182024; FR182024. 9031SV3FWE; (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Grade: 98%. CAS No. 179034-83-4. Molecular formula: C18H16N4O4S3. Mole weight: 448.53. | |
| FR-182980 | FR-182980, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hypercholesterolaemia. Synonyms: FR-182980; FR182980; FR 182980; 1-cycloheptyl-1-[[4-(4-fluorophenoxy)phenyl]methyl]-3-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]urea. Grade: 98%. CAS No. 179054-51-4. Molecular formula: C29H34FN3O2S2. Mole weight: 539.73. | |
| FR183998 | FR183998 is a Na+/H+ exchanger inhibitor. Inhibition of the Na+/H+ exchanger improves heart and brain injuries induced by I/R. Synonyms: FR-183998. Grade: 98%. CAS No. 239440-20-1. Molecular formula: C17H19Cl2N5O2S. Mole weight: 428.34. | |
| FR-186054 | FR-186054, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hyperlipidaemia. Synonyms: FR-186054; FR 186054; FR186054; 1-benzyl-3-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]-1-[[3-(1H-pyrazol-5-yl)phenyl]methyl]urea. Grade: 98%. CAS No. 179053-90-8. Molecular formula: C26H27N5OS2. Mole weight: 489.66. | |
| FR-188582 | FR-188582, with anti-inflammatory and ulcerogenic properties, is a highly selective inhibitor of COX-2 with IC50=0.017 microM. Synonyms: 3-chloro-5-(4-methylsulfonylphenyl)-1-phenylpyrazole; FR 188582; FR188582; FR-188582. Grade: >98%. CAS No. 189699-82-9. Molecular formula: C16H13ClN2O2S. Mole weight: 332.8. | |
| FR-190809 | FR-190809 is a potent and orally efficacious ACAT inhibitor potentially for the treatment of Lipoprotein Disorders. Synonyms: 1-cycloheptyl-1-[[4-(4-fluorophenoxy)phenyl]methyl]-3-[6-methyl-2,4-bis(methylsulfonyl)pyridin-3-yl]urea; FR-190809; FR 190809; FR190809.N-cycloheptyl-N-(4-(4-fluorophenoxy)-benzyl)-N'-(2,4-bis(methylsulfonyl)-6-methylpyridin-3-yl)urea. Grade: >98%. CAS No. 215589-63-2. Molecular formula: C29H34FN3O6S2. Mole weight: 603.73. | |
| FR-193262 | FR-193262 is a designed prostacyclin mimetic without PG skeleton which exhibits potent PGI2 agonistic activity with good selectivity for IP receptor and bioavailability. Synonyms: FR-193262; FR 193262; FR193262; sodium; 2-[[(5R)-5-[(2R)-2-(4,5-diphenyl-1,3-oxazol-2-yl)pyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetate; FR-193262; 187992-22-9(FR-193262); 314289-63-9 (FR-193262 Free Base). Grade: >98%. CAS No. 187992-22-9. Molecular formula: C31H29N2NaO4. Mole weight: 516.56. | |
| FR-193262 Free base | A bio-active organic chemical. Uses: A bio-active organic chemical. Synonyms: FR-193262; FR 193262; FR193262; 2-[[(5R)-5-[(2R)-2-(4,5-diphenyl-1,3-oxazol-2-yl)pyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetic acid. Grade: ≥98%. CAS No. 314289-63-9. Molecular formula: C31H30N2O4. Mole weight: 494.59. | |
| FR-193879 | FR-193879, a cephem derivative, is an efficacious anti-Helicobacter pylori cephalosporin. Synonyms: (6R,7R)-3-[[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; FR-193879; FR193879; FR 193879. Grade: >98%. CAS No. 194928-82-0. Molecular formula: C20H18N4O5S3. Mole weight: 490.58. | |
| FR-194921 | FR-194921 is a potent, selective and orally active antagonist for central adenosine A1 receptors that displays high affinity and selectivity for the adenosine A1 receptor (Ki= 2.9 nM) and did not show species differences in binding affinity. Synonyms: 2-(1-methylpiperidin-4-yl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3-one; FR-194921; FR 194921; FR194921; 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-3(2H)-pyridazinone. Grade: >98%. CAS No. 202646-80-8. Molecular formula: C23H23N5O. Mole weight: 385.46. | |
| FR-202306 | FR-202306 is a synthetic peptide deformylase (PDF) inhibitor. Uses: Peptide deformylase (pdf) inhibitor. Synonyms: FR-202306; FR 202306; FR202306. 3-methoxy-7-methyl-1,3-dihydro-2-benzofuran-4,5,6-triol. Grade: ≥98%. CAS No. 342785-41-5. Molecular formula: C10H12O5. Mole weight: 212.20. | |
| FR-217840 | FR-217840 is a matrix metalloproteinase inhibitor. It can suppress joint destruction. FR217840 may have potential as a novel anti-rheumatic drug. Uses: Anti-rheumatic agent. Synonyms: FR-217840; FR217840; FR 217840. (2S)-1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-2-Piperazinecarboxamide. Grade: 98%. CAS No. 848444-16-6. Molecular formula: C16H18FN3O6S3. Mole weight: 463.52. | |
| FR-218944 | FR-218944 is a vasopressin antagonist compound. Synonyms: methanesulfonic acid; 2-methoxy-N-(2-methyl-1H-benzimidazol-4-yl)-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)benzamide; FR-218944; FR 218944; FR218944. Grade: >98%. CAS No. 233264-02-3. Molecular formula: C28H30N4O6S. Mole weight: 550.63. | |
| FR-221647 | FR-221647 is a non-nucleoside adenosine deaminase inhibitor. Synonyms: 1-(1-hydroxy-4-phenylbutan-2-yl)imidazole-4-carboxamide; FR-221647; FR 221647; FR221647. Grade: >98%. CAS No. 256461-28-6. Molecular formula: C14H17N3O2. Mole weight: 259.3. | |
| FR-229934 | FR-229934 is a Type 5 cyclic nucleotide phosphodiesterase inhibitor. In Feb 2008, preclinical for Erectile dysfunction in Japan was discontinued. Uses: Erectile dysfunction. Synonyms: FR-229934; FR229934; FR 229934. 1-((3,4-dichlorophenyl)methyl)-2-methyl-N-(pentylsulfonyl)-1H-Benzimidazole-6-carboxamide. Grade: 98%. CAS No. 799841-02-4. Molecular formula: C21H23Cl2N3O3S. Mole weight: 468.40. | |
| FR-234938 | FR-234938, with anti-inflammatory property, is a non-nucleoside recombinant human adenosine deaminase enzyme inhibitor. Synonyms: 1-[(3R,4S)-4-hydroxy-1-naphthalen-1-ylpentan-3-yl]imidazole-4-carboxamide; FR-234938; FR 234938; FR234938. Grade: >98%. CAS No. 256461-79-7. Molecular formula: C19H21N3O2. Mole weight: 323.39. | |
| FR236913 | FR236913 is a compoundused in studying chronic lymphocytic leukemia (CLL) and other hematologic malignancies. This targeted therapy inhibits Bruton's tyrosine kinase (BTK) is a key enzyme in the B-cell receptor signaling pathway. By disrupting abnormal B-cell signaling, FR236913 helps control the progression of CLL. Synonyms: 1-[(2R)-4-{6-[(Benzylcarbamoyl)amino]-1H-indol-1-yl}-1-hydroxybutan-2-yl]-1H-imidazole-4-carboxamide. Molecular formula: C24H26N6O3. Mole weight: 446.5. | |
| FR 236924 | FR 236924 is a selective PKCε activator with > 7-fold selectivity over other PKC isozymes. FR 236924 promotes glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. It has the potential for the treatment of Alzheimer disease. Synonyms: FR 236924; FR236924; FR-236924; Dcp-LA; 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid. Grade: ≥99% by HPLC. CAS No. 28399-31-7. Molecular formula: C20H36O2. Mole weight: 308.5. | |
| FR252384 | FR252384 is novel potent antagonists of human neuropeptide Y-Y5 receptor (IC50= 2.3 nM). Synonyms: FR252384; FR 252384; FR-252384; 9-methyl-2-pyridin-3-yl-3,4,5,6-tetrahydrobenzo[2,3]cyclohepta[2,4-b]imidazole; Benzo[3,4]cyclohept[1,2-d]imidazole, 1,4,5,6-tetrahydro-9-methyl-2-(3-pyridinyl)-. CAS No. 447405-11-0. Molecular formula: C18H17N3. Mole weight: 275.35. | |
| FR295389 free base | FR295389 free base is a new cephalosporin. It shows effective in vitro antibacterial activity against metallo-beta-lactamase (MBL)-producers. Uses: Fr295389 free base has effective antibacterial activity. Synonyms: FR-295389 free base; FR 295389 free base; FR295389 free base; (6R,7R)-3-[[7-[3-aminopropyl(carbamimidoyl)amino]-2,3-dihydroimidazo[1,2-b]pyrazol-5-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Grade: >98 %. CAS No. 1019207-71-6. Molecular formula: C25H33N13O7S2. Mole weight: 691.74. | |
| FR295389 sulfuric acid | FR295389 sulfuric acid is the sulfate form of FR295389, which is a new cephalosporin. It has effective in vitro antibacterial activity against metallo-beta-lactamase (MBL)-producers. Uses: Fr295389 sulfuric acid has effective antibacterial activity. Synonyms: FR-295389 sulfuric acid; FR 295389 sulfuric acid; FR295389 sulfuric acid; (6R,7R)-3-[[7-[3-aminopropyl(carbamimidoyl)amino]-2,3-dihydroimidazo[1,2-b]pyrazol-5-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sulfuric acid. Grade: >98 %. CAS No. 1019207-72-7. Molecular formula: C25H35N13O11S3. Mole weight: 789.81. | |
| FR-62765 | FR-62765, a derivative of WF-3681, is a novel aldose reductase inhibitor. It might be a useful drug for diabetic neuropathy. Uses: Fr-62765 might be a useful drug for diabetic neuropathy. Synonyms: FR 62765; FR-62765; FR62765. 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester; FR62765; 2,5-Dihydro-4-methoxy-5-oxo-3-phenylfuran-2-propanoic acid ethyl ester; Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate; Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate. Grade: >98 %. CAS No. 105346-34-7. Molecular formula: C16H18O5. Mole weight: 290.31. | |
| FR-64822 | FR-64822 is a novel non-opioid antinociceptive compound. It has antinociceptive activities in a variety of assays in mice and rats. It also has a strong antinociceptive activity in the acetic acid writhing test. Uses: Fr-64822 has antinociceptive activities. Synonyms: FR 64822; FR64822; FR-64822. N-(4-Pyridylcarbamoyl)amino 1,2,3,6-tetrahydropyridine; 1-(3,6-dihydro-2H-pyridin-1-yl)-3-pyridin-4-ylurea; FR64822. Grade: >98 %. CAS No. 102671-35-2. Molecular formula: C11H14N4O. Mole weight: 218.26. | |
| FR 75513 | FR 75513 is a 1,1'-biphenyl-2,6-dicarboxylic acid diester compound with inhibitory activity on guinea-pig detrusor muscle contraction at electrical field stimulation in vitro. IC 50 value is 3.3 x 10(-6) g/ml. Synonyms: FR 75513; FR75513; FR-75513. 3-O-methyl 1-O-propan-2-yl 4-hydroxy-6-methyl-2-(2-nitrophenyl)benzene-1,3-dicarboxylate. Grade: 98%. CAS No. 127975-78-4. Molecular formula: C19H19NO7. Mole weight: 373.36. | |
| FR 76830 | This molecular is developed as a novel bradycardiac agent through organic synthesis. Uses: Bradycardiac agent. Synonyms: FR 76830; FR-76830; FR76830. 2-methyl-N-(4-morpholinylethyl)-4-(3-nitrophenyl)-6-phenyl- 3-Pyridinecarboxamide. Grade: 98%. CAS No. 113243-75-7. Molecular formula: C25H26N4O4. Mole weight: 446.5. | |
| FR-78844 | FR-78844 is used as a bone resorption antagonist. Uses: Fr-78844 is used as a bone resorption antagonist. Synonyms: FR 78844; FR78844; FR-78844; Disodium phenylthiocarbamoylmethylenediphosphonate; (2-(Phenylamino)-2-thioxoethylidene)bisphosphonic acid disodium salt; Disodium [2-anilino-1-[hydroxy(oxido)phosphoryl]-2-sulfanylideneethyl]-hydroxyphosphinate; FR78844; Phosphonic acid, (2-(phenylamino)-2-thioxoethylidene)bis-, disodium salt. Grade: >98%. CAS No. 112856-39-0. Molecular formula: C8H9NNa2O6P2S. Mole weight: 355.15. | |
| FR900098 sodium salt | FR900098 is a derivative of fosmidomycin that displays antimalarial activity. FR900098 is an inhibitor of DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Synonyms: (3-(Acetylhydroxyamino)propyl)-phosphonic acid, monosodium salt; BRN 2096083; P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid, monosodium salt. Grade: ≥95%. CAS No. 73226-73-0. Molecular formula: C5H11NO5P·Na. Mole weight: 219.1. | |
| FR-A 19 | FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar range. Uses: Anti-allergic agent. Synonyms: FR-A 19; FR-A-19; FRA19; N,N-bis(3-(4-fluorophenyl)propyl)-N'-(3-(1H-imidazol-4-yl)propyl)-Guanidine trihydrochloride. Grade: 98%. CAS No. 141099-46-9. Molecular formula: C25H34Cl3F2N5. Mole weight: 548.93. | |
| Fradafiban | Fradafiban, a figrinogen receptor antagonist, is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, with a Kd of 148 nM for binding to the human platelet GP IIb/IIIa complex. Synonyms: BIBU-52; (3S,5S)-5-(((4'-Amidino-4-biphenylyl)oxy)methyl)-2-oxo-3-pyrrolidineacetic acid; (3S-trans)-5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-3-pyrrolidineacetic acid; [(3S,5S)-5-{[(4'-Carbamimidoylbiphenyl-4-yl)oxy]methyl}-2-oxopyrrolidin-3-yl]acetic acid; 3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)-. Grade: ≥95%. CAS No. 148396-36-5. Molecular formula: C20H21N3O4. Mole weight: 367.40. | |
| Fragment (27-32)-Calcitonin | Fragment (27-32)-Calcitonin is an impurity of Calcitonin salmon, which is a calcium regulating hormone used to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: Thr-Gly-Ser-Gly-Thr-Pro-OH; L-Threonylglycyl-L-serylglycyl-L-threonyl-L-proline; L-Proline, L-threonylglycyl-L-serylglycyl-L-threonyl-; H-TGSGTP-OH. Grade: ≥95%. CAS No. 922492-91-9. Molecular formula: C20H34N6O10. Mole weight: 518.52. | |
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