BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Vatalanib | Vatalanib, also called as PTK 787 or CGP 797870, is a small molecule that interacts reversibly and competitively at the ATP-binding site of the receptor tyrosine kinase domain to inhibit autophosphorylation. It targets all known VEGFR tyrosine kinases. Synonyms: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK787; PTK 787; PTK-787; ZK 222584; ZK222584; ZK-222584; CGP 79787; CGP-797870; ZK-232934; CGP79787D; ZK 222584; CGP-7978. Grades: >98%. CAS No. 212141-54-3. Molecular formula: C20H15ClN4. Mole weight: 346.81. |  |
| Velpatasvir | Velpatasvir is a selective Hepatitis C virus NS 5 protein inhibitor originated by Gilead Sciences. It showed pan-genotypic activity and a high barrier to resistance in HCV replicon assays. Uses: Antiviral agents. Synonyms: GS5816; GS-5816; GS 5816; Velpatasvir; methyl ((R)-2-((2S, 4S)-2-(5-(2-((2S, 5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidin-2-yl)-1, 11-dihydroisochromeno[4', 3':6, 7]naphtho[1, 2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate. Grades: >98%. CAS No. 1377049-84-7. Molecular formula: C49H54N8O8. Mole weight: 883.01. | |
| Vemurafenib | Vemurafenib is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity than wild-type B-Raf. Synonyms: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Brand name: Zelboraf. Grades: >98%. CAS No. 918504-65-1. Molecular formula: C23H18ClF2N3O3S. Mole weight: 489.92. | |
| venetoclax | Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL). Uses: The treatment of chronic lymphocytic leukemia (cll). Synonyms: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax. CAS No. 1257044-40-8. Molecular formula: C45H50ClN7O7S. Mole weight: 868.44. | |
| Verapamil hydrochloride | Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Synonyms: Benzeneacetonitrile, α -[3-[[2- (3, 4-dimethoxyphenyl) ethyl]methylamino]propyl]-3, 4-dimethoxy-α - (1-methylethyl) -, hydrochloride (1:1); Verapamil HCl; Manidon; Calcan hydrochloride; Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride; (±)-Verapamil hydrochloride; Akilen; Anpec; Apo-Verap; Apoacor; Berkatens; Calan; Dignover; dl-Verapamil hydrochloride; Drosteakard; Finoptin; Flamon; Geangin; Hexasoptin; Ikacor; Iproveratril hydrochloride; Isoptin, hydrochloride; Izoptin hydrochloride; Lekoptin Retard; LU 20175; NSC 272366; NSC 657799; Quasar; Ravamil SR; Securon; Univer; Vasolan; Vetrimil. Grades: >98%. CAS No. 152-11-4. Molecular formula: C27H38N2O4.HCl. Mole weight: 491.06. | |
| Verapamil Impurity J HCl | Verapamil Impurity J HCl is a metabolite of Verapamil. Verapamil is a medication used for the treatment of high blood pressure, chest pain from not enough blood flow to the heart, and supraventricular tachycardia. Synonyms: Nor Verapamil Hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzeneacetonitrile. CAS No. 67812-42-4. Molecular formula: C26H36N2O4. HCl. Mole weight: 477.05. | |
| Vericiguat | Vericiguat is a potent guanylate cyclase stimulant under the development of Bayer HealthCare Pharmaceuticals. Direct stimulation of guanylate cyclase is emerging as a potential new approach for the treatment of renal disorders. In Aug 2016, Bayer in collaboration with Merck completed phase-I clinical trials in Coronary artery disease (In adults, In the elderly) in Germany. In Sep 2016, Phase-III clinical trials in Chronic heart failure in Germany, Hungary and Spain was on-going. Uses: Chronic heart failure; coronary artery disease. Synonyms: BAY1021189; BAY 1021189; BAY-1021189; BAY10-21189; BAY-10-21189; BAY 10-21189; methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate. Grades: 98%. CAS No. 1350653-20-1. Molecular formula: C19H16F2N8O2. Mole weight: 426.39. | |
| Verucerfont | Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000?nM for CRF1, CRF2, and CRF-BP, respectively. Verucerfont supresses the CRH-1 receptor to decrease ACTH release following chronic stress. Synonyms: GSK561679; GSK 561679; GSK-561679; GSK561679A; NBI-77860; NBI 77860; NBI77860; 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine. CAS No. 885220-61-1. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| Vigabatrin | Vigabatrin is an analogue of gamma-aminobutyric acid(GABA) and is an irreversible inhibitor of 4-aminobutyrate transaminase. It is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. It is an antiepileptic drug that inhibits the breakdown of GABA by acting as a suicide inhibitor of GABA transaminase (GABA-T). It increases brain concentrations of GABA, an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is a racemic compound, and its [S]-enantiomer is pharmacologically active. It has been listed. Uses: Vigabatrin is used in combination with other agents as therapy of refractory complex partial seizures and as monotherapy for infantile spasms. it is an antiepileptic drug. Synonyms: γ-Vinyl-GABA; 4-Amino-5-hexenoic Acid; (±)-4-Amino-5-hexenoic Acid; Sabril; Vigabatrine; 4-Aminohexenoic acid; rac-Vigabatrin; (±)-Vigabatrin; (±)-4-Aminohexenoic acid. Grades: ≥98%. CAS No. 68506-86-5. Molecular formula: C6H11NO2. Mole weight: 129.16. | |
| Vigabatrin EP Impurity E | Vigabatrin EP Impurity E is a derivative of Vigabatrin. Vigabatrin is an inhibitor of the enzyme GABA transaminase (GABA-T) used as an antiepileptic drug. Synonyms: 2-(2-Aminobut-3-enyl)malonic Acid. CAS No. 1378466-25-1. Molecular formula: C7H11NO4. Mole weight: 173.17. | |
| Vigabatrin Hydrochloride | A novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic. Synonyms: γ-Vinyl-GABA hydrochloride; Sabril hydrochloride. Grades: >98%. CAS No. 1391054-02-6. Molecular formula: C6H12ClNO2. Mole weight: 165.62. | |
| Vilanterol Trifenatate | Vilanterol, also known as GW-642444, is a long-acting beta-2 agonist drug, which in May 2013 was approved in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD). Synonyms: (R) -4- (2- ( (6- (2- ( (2, 6-dichlorobenzyl) oxy) ethoxy) hexyl) amino) -1-hydroxyethyl) -2- (hydroxymethyl) phenol 2,2,2-triphenylacetate; GW-642444; GW642444; GW-642444; GW 642444X; Vilanterol; Vilanterol trifenatate. Grades: 98%. CAS No. 503070-58-4. Molecular formula: C24H33Cl2NO5.C20H16O2. Mole weight: 774.776. | |
| Vilaprisan | Vilaprisan is a selective oral progesterone receptor antagonist under the development of Bayer HealthCare Pharmaceuticals. BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005) in a human fibroid xenograft model. Now clinical trials Phase III for Endometriosis and Uterine leiomyoma was on-going. Synonyms: BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670. Grades: 98%. CAS No. 1262108-14-4. Molecular formula: C27H29F5O4S. Mole weight: 544.58. | |
| Vinblastine Impurity K | Cas No. 71486-22-1. | |
| Vitamin A2 Nitrile | Vitamin A2 Nitrile, a nitrile derivative of retinoic acid, is an intermediate in the synthesis of Vitamin A derivatives and an isomer of Retinal. Synonyms: 3-Dehydroretinonitrile; Retinonitrile, 3,4-didehydro-; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraenenitrile. Grades: ≥95%. CAS No. 6248-59-5. Molecular formula: C20H25N. Mole weight: 279.42. | |
| Vitamin K2(45) | . Uses: Vitamin (prothrombogenic). Synonyms: menaquinone 9; (all-E)-2-Methyl-3-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-1,4-naphthalenedione; Menaquinone MK 9; Menlaquinone 9; MK 9; Vitamin MK 9. Grades: 97%. CAS No. 523-39-7. Molecular formula: C56H80O2. Mole weight: 785.25. | |
| VKGILS-NH2 | VKGILS-NH2 is a reversed control peptide for SLIGKV-NH2, which is a protease-activated receptor 2 (PAR2) agonist. Synonyms: retro-PAR-2 (1-6) amide (human); retro-SLIGKVamide; Thrombin Receptor-Like 1 (6-1) amide (human); Proteinase Activated Receptor 2 (6-1) amide (human); PAR-2 (6-1) amide (human). Grades: 98%. CAS No. 942413-05-0. Molecular formula: C28H54N8O7. Mole weight: 614.79. | |
| Voclosporine | Voclosporine is an orally available calcineurin inhibitor and potent immunosuppressant used in combination with mycophenolate mofetil and corticosteroids for the treatment of acute lupus nephritis. Uses: A new agent for the treatment of noninfectious uveitis. uveitis is an inflammatory, putative th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. voclosporin, a rationally designed novel calcineurin. Synonyms: 6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A; ISATX 247; R 1524; trans-ISA 247; Voclosporin; Luveniq; Lupkynis; 1,11-anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)nona-6,8-dienoyl][(2S)-2-aminobutanoyl]-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]. Grades: >98%. CAS No. 515814-01-4. Molecular formula: C63H111N11O12. Mole weight: 1214.62. | |
| Vonoprazan Fumarate | TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Synonyms: TAK438; TAK-438; TAK 438. Grades: 98%. CAS No. 881681-01-2. Molecular formula: C17H16FN3O2S.C4H4O4. Mole weight: 461.46. | |
| Vonoprazan Fumarate Impurity 4 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Grades: 95%. CAS No. 2169271-28-5. Molecular formula: C16H13FN2O3S. Mole weight: 332.35. | |
| Vonoprazan Impurity 1 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: N-methyl(5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methanamine fumarate salt. CAS No. 881732-90-7. Molecular formula: C17H17N3O2S. Mole weight: 327.41. | |
| Vonoprazan Impurity 17 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1883595-38-7; 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxylic acid1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-Vonoprazan Impurity 17CS-0163877. Grades: 95%. CAS No. 1883595-38-7. Molecular formula: C11H8FNO2. Mole weight: 205.18. | |
| Vonoprazan Impurity 19 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Grades: 95%. CAS No. 881674-58-4. Molecular formula: C11H10FNO. Mole weight: 191.20. | |
| Vonoprazan Impurity 23 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 1-(5-(2-Fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine. Grades: 95%. CAS No. 1610043-62-3. Molecular formula: C12H13FN2. Mole weight: 204.24. | |
| Vonoprazan Impurity 24 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: Vonoprazan N-Oxide Impurity. Grades: 95%. CAS No. 1883595-39-8. Molecular formula: C17H14FN3O3S. Mole weight: 359.37. | |
| Vonoprazan Impurity 28 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 2-phenyl-4-formylpyrrole; 5-Phenylpyrrole-3-carbaldehyde. Grades: 95 %. CAS No. 56448-22-7. Molecular formula: C11H9NO. Mole weight: 171.19. | |
| Vonoprazan Impurity 29 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: 881676-90-0; 5-Phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-phenyl-1-pyridin-3-ylsulfonylpyrrole-3-carbaldehyde; Vonoprazan Impurity 29; SCHEMBL1156702. Grades: 95%. CAS No. 881676-90-0. Molecular formula: C16H12N2O3S. Mole weight: 312.34. | |
| Vonoprazan Impurity 67 | One of the impurities of Vonoprazan, which is a potassium-competitive acid blocker and has been found to be effective in the treatment of gastroduodenal ulcer and reflux esophagitis. Synonyms: N,N-Dimethylmethanamine Vonoprazan. Grades: 95%. CAS No. 1885094-62-1. Molecular formula: C18H18FN3O2S. Mole weight: 359.42. | |
| Vorapaxar | SCH-530348 is a novel antiplatelet agent undergoing development by Schering-Plough Corp for the treatment and prevention of atherothrombosis. It is currently undergoing Phase-III clinical trials for acute coronary syndrome (unstable angina/non-ST segment elevation myocardial infarction) and secondary prevention of cardiovascular events in high-risk patients. Uses: Platelet aggregation inhibitors. Synonyms: N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]carbamic Acid Ethyl Ester Sulfate; Sch 530348. Grades: 0.98. CAS No. 618385-01-6. Molecular formula: C29H33FN2O4. Mole weight: 492.58. | |
| Vorapaxar Sulfate | Vorapaxar, also known as SCH 530348, is a thrombin receptor (protease-activated receptor, PAR-1) antagonist based on the natural product himbacine. Synonyms: SCH530348; SCH 530348, SCH-530348; Vorapaxar sulfate. Grades: 98%. CAS No. 705260-08-8. Molecular formula: C29H35FN2O8S. Mole weight: 590.66. | |
| Voriconazole Impurity 8 | One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: (αR,βR)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol. CAS No. 239807-03-5. Molecular formula: C16H14F3N5O. Mole weight: 349.32. | |
| Vortioxetine | Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Uses: For research used only. Synonyms: Lu AA 21004; Lu AA21004. Grades: 0.98. CAS No. 508233-74-7. Molecular formula: C18H22N2S. Mole weight: 298.448. | |
| Vortioxetine HBr | Vortioxetine is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Synonyms: Lu AA21004; LuAA21004; Lu-AA21004. Grades: >98%. CAS No. 960203-27-4. Molecular formula: C18H22N2S·HBr. Mole weight: 379.36. | |
| VPA-985 | VPA-985, an azepine compound, has been found to be a Vasopressin receptor antagonist that could be used in some cardiovascular disease therapy like hyponatraemia. Uses: Drug used in the treatment and prevention of cardiovascular diseases. Synonyms: CRTX-080; CRTX080; CRTX 080; VPA-985; VPA985; VPA 985; WAY-VPA-985; Lixivaptan; N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide;Lixivaptan; VPA-985. Grades: 98%. CAS No. 168079-32-1. Molecular formula: C27H21ClFN3O2. Mole weight: 473.94. | |
| VPS34-IN1 | VPS34-IN1 is a potent and selective Vps34 inhibitor with potential anticancer activity. VPS34-IN1 inhibits Vps34 with 25 nM IC50 in vitro. Synonyms: VPS34IN1; VPS34 IN1; VPS34-IN1. Grades: 98%. CAS No. 1383716-33-3. Molecular formula: C21H24ClN7O. Mole weight: 425.91. | |
| VU0152099 | VU0152099 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine. Synonyms: VU 0152099; VU-0152099. Grades: 98%. CAS No. 612514-42-8. Molecular formula: C18H17N3O3S. Mole weight: 355.41. | |
| VU 0357017 hydrochloride | The hydrochloride salt form of VU0357017 which is a selective M1 agonist and has been found to be probably effective in the treatment of hippocampal-dependent cognitive function deficits. EC50=477 ± 172 nM. Synonyms: VU0357017; VU-0357017; VU 0357017; CID 25010775; CID25010775; CID-25010775; 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride. Grades: >98%. CAS No. 1135242-13-5. Molecular formula: C18H27N3O3.HCl. Mole weight: 369.89. | |
| VU0467154 | VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. It potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). Synonyms: 5-Amino-3, 4-dimethyl-N-[[4- (trifluoromethylsulfonyl) phenyl]methyl]thieno[2, 3-c]pyridazine-6-carboxamide. Grades: ≥95%. CAS No. 1451993-15-9. Molecular formula: C17H15F3N4O3S2. Mole weight: 444.45. | |
| WAY-100635 maleate | WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist for 5-HT ( IC50= 0.95 ± 0.12 nM ), and also exhibits agonist activity at dopamine D4 receptors. Uses: Potent, silent antagonist of 5-ht1a receptors. Synonyms: WAY-100635 maleate; WAY 100635 maleate; WAY100635 maleate; (Z)-but-2-enedioic acid;N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide. Grades: ≥98%. CAS No. 634908-75-1. Molecular formula: C29H38N4O6. Mole weight: 538.64. | |
| WAY 150138 | WAY 150138, belonging to a novel group of thiourea compounds, can cause the inhibition of the herpes simplex virus. Synonyms: WAY 150138; WAY150138; WAY-150138; 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine; Vectarion; Almitrin; Almitrina; Almitrinum; Almitrine. Grades: >98%. CAS No. 273388-09-3. Molecular formula: C22H18Cl2FN3O3S. Mole weight: 494.36. | |
| WAY-320461 | WAY-320461 is a FAK inhibitor. Synonyms: WAY 320461; WAY320461. CAS No. 491839-65-7. Molecular formula: C15H10BrN3O2S. Mole weight: 376.2. | |
| WAY-323096 | WAY-323096 is a bioactive compound. Synonyms: WAY 323096; WAY323096; 2-(4-(4-Chlorophenyl)-1-oxophthalazin-2(1H)-yl)-N-(4-fluorophenyl)acetamide. CAS No. 684234-60-4. Molecular formula: C22H15ClFN3O2. Mole weight: 407.8. | |
| WAY-641966 | WAY-641966 is an anti-prion agent. Synonyms: WAY 641966; WAY641966. CAS No. 259870-32-1. Molecular formula: C20H16N4. Mole weight: 312.4. | |
| WEHI-345 | WEHI-345, a pyrazolo-pyridine derivative, is a RIPK2 inhibitor and has been found to influence the production of inflammatory cytokine. IC50: 0.13 μM. Uses: Wehi-345 is a ripk2 inhibitor and has been found to influence the production of inflammatory cytokine. Synonyms: WEHI-345; WEHI345; WEHI 345. SCHEMBL10098386; CS-5045; HY-18937; CS 5045; HY 18937; CS5045; HY18937. Grades: 98%. CAS No. 1354825-58-3. Molecular formula: C22H23N7O. Mole weight: 401.46. | |
| WHI-P180 | WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity. The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. Synonyms: WHI-P180; WHI-P-180; WHI-P 180; 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol; Janex 3; WHI-P 180; WHIP180. CAS No. 211555-08-7. Molecular formula: C16H15N3O3. Mole weight: 297.31. | |
| WHI-P258 | WHI-P258 is a Janus kinase 3 (JAK3) inhibitor. Synonyms: WHI-P258; WHI-P 258; WHI-P-258; WHIP 258; 6,7-Dimethoxy-N-phenylquinazolin-4-amine. CAS No. 21561-09-1. Molecular formula: C16H15N3O2. Mole weight: 281.315. | |
| WS12 | WS12 is a potent TRPM8 agonist. It acts as a cooling agent with EC50 value of 193 nM. It robustly activated TRPM8 in low micromolar concentrations, thus displaying a higher potency and efficacy compared to menthol. Uses: It is a good flotation agent for quartz and is also the most effective agent in asphalt emulsifier. it also can be used to waterproof and corrosion inhibitors and additive in petroleum products. and is an intermediate for the manufacture of amine salts, amine oxides, betaines, quaternaries, etc. it can be used in emollients, emulsifiers and foaming agents conditioners ,softeners, etc. it can be used for bath preparation, hair conditioner, skin care agent, shampoo, chemical compound, and cutting lubrication oil. Synonyms: WS 12; WS-12; WS12. (1R,2S)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide;(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide. Grades: 98%. CAS No. 68489-09-8. Molecular formula: C18H27NO2. Mole weight: 289.41. | |
| WS3 | WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. Synonyms: WS3; WS-3; WS 3. Grades: >98%. CAS No. 1421227-52-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.58. | |
| WZ-4002 | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Synonyms: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. | |
| WZB 117 | WZB 117 is a GLUT inhibitor (Ki(app) = 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively) that inhibits passive glucose transport in human erythrocytes and cancer cell lines. It decreases extracellular lactate and intracellular ATP levels. WZB 117 was shown to attenuate erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM) and inhibits tumor growth in a nude mouse model. Synonyms: WZB117; WZB-117; WZB 117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate). Grades: ≥98% by HPLC. CAS No. 1223397-11-2. Molecular formula: C20H13FO6. Mole weight: 368.31. | |
| X-396 | X-396 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors; ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors. Uses: Antineoplastic agents. Synonyms: X-376; (R)-6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide; 3-Pyridazinecarboxamide, 6-amino-5-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((4-methyl-1-piperazinyl)carbonyl)phenyl)-; 6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-{4-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-3-pyridazinecarboxamide. Grades: ≥98%. CAS No. 1365267-27-1. Molecular formula: C25H25Cl2FN6O3. Mole weight: 547.41. | |
| Ximelagatran | Ximelagatran, an ester prodrug of melagatran, with anticoagulant effect, is the first member of direct thrombin inhibitors that can be taken orally. Uses: An orally active direct thrombin inhibitor; prodrug of melagatran. antithrombotic. Synonyms: H 376-95; H 376/95; H 37695; H-37695; H37695; N- [ (1R) -1-Cyclohexyl-2- [ (2S) -2- [ [ [ [4- [ (hydroxyamino) iminomethyl] phenyl] methyl] amino] carbonyl] -1-azetidinyl] -2-oxoethyl] glycine Ethyl Ester; Exanta; H 376/95. Grades: >98%. CAS No. 192939-46-1. Molecular formula: C24H35N5O5. Mole weight: 473.57. | |
| XL147 | Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and inhibiting the activation of the PI3K signaling pathway. Uses: Pilaralisib has potential antineoplastic activity. Synonyms: XL147-II; XL147 II; XL147II; XL147 derivative II; XL147derivativeII; XL147-derivative-II; N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide;SAR245408;N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide;PI3K inhibitorX. Grades: >99%. CAS No. 956958-53-5. Molecular formula: C21H16N6O2S2. Mole weight: 448.52. | |
| XL-647 | XL647 is an orally bioavailable small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It inhibits EGFR, HER2, VEGFR and EphB4 kinase. Synonyms: XL-647; XL 647; XL647; EXEL-7647; EXEL 7647; EXEL7647; KD-019; KD 019; KD019. Grades: >98%. CAS No. 781613-23-8. Molecular formula: C24H25Cl2FN4O2. Mole weight: 491.39. | |
| XL 765 | XL 765 is a PI3K inhibitor used for the treatment of cancers. It also suppresses DNA-PK and mTOR. Synonyms: XL765-II; XL765 II; XL765II; XL 765-II; XL-765-II; SAR 245409; SAR245409; SAR-245409; N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide; N-(4-(N-(3-((3,5-Dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide. CAS No. 1349796-36-6. Molecular formula: C31H29N5O6S. Mole weight: 599.662. | |
| YH-306 | YH-306 is a candidate drug in preventing growth and metastasis of CRC by modulating FAK signalling pathway. Synonyms: YH 306; YH306. CAS No. 1373764-75-0. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| YKL-05-099 | YKL-05-099 has slightly less potent SIK2-inhibitory (IC50 = 40 ± 25 nM) and IL-10-enhancing activities (EC50 = 460 ± 110 nM), but is non-toxic at concentrations ≤ 10 μM and stable in mouse liver microsomes for > 2 hours. Synonyms: YKL 05 099; YKL05099. CAS No. 1936529-65-5. Molecular formula: C32H34ClN7O3. Mole weight: 600.11. | |
| YKL-06-061 | YKL-06-061 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 6.56 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Synonyms: YKL06-061; YKL 06-061; YKL-06061. CAS No. 2172617-15-9. Molecular formula: C30H37N7O2. Mole weight: 527.67. | |
| (Z)-11-Hexadecenyl acetate | Synonyms: 11-Hexadecen-1-ol acetate, (Z)-; (Z)-Hexadec-11-en-1-yl acetate. Grades: ≥90%. CAS No. 34010-21-4. Molecular formula: C18H34O2. Mole weight: 282.46. | |
| (Z)-2-[2-(Tritylamino)thiazol-4-yl]-2-(trityloxyimino)acetic Acid Ethyl Ester | (Z)-2-[2-(Tritylamino)thiazol-4-yl]-2-(trityloxyimino)acetic Acid Ethyl Ester is one of Cefdinir intermediates. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: (Z)-α-[(Triphenylmethoxy)imino]-2-[(triphenylmethyl)amino]-4-thiazoleacetic Acid Ethyl Ester; (Z)-ethyl-2-(2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino) acetate; (αZ)-α-[(Triphenylmethoxy)imino]-2-[(triphenylmethyl)amino]-4-thiazoleacetic Acid Ethyl Ester; (2-tritylamino-thiazol-4-yl)-(Z)-trityloxyimino-acetic acid ethyl ester. Grades: ≥95%. CAS No. 69689-86-7. Molecular formula: C45H37N3O3S. Mole weight: 699.86. | |
| (Z)-2'-(benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic acid | (Z)-2'-(benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic acid is an impurity of Eltrombopag, a drug used in the treatment of thrombocytopenia (abnormally low platelet count) for severe aplastic anemia. CAS No. 2131025-93-7. Molecular formula: C32H28N4O4. Mole weight: 532.60. | |
| (Z)-2-(Trityloxyimino)-2-[2-(tritylamino)thiazol-4-yl]acetic Acid | (Z)-2-(Trityloxyimino)-2-[2-(tritylamino)thiazol-4-yl]acetic Acid is one of Cefdinir intermediates. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: (Z)-α-[(Triphenylmethoxy)imino]-2-[(triphenylmethyl)amino]-4-thiazoleacetic Acid; (Z)-2-(2-Tritylaminothiazol-4-yl)-2-trityloxyiminoaceticacid; 2-(syn-trityloxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid; ATDA; TTOA. Grades: 98%. CAS No. 68786-47-0. Molecular formula: C43H33N3O3S. Mole weight: 671.80. | |
| (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic acid | (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic acid is an impurity of Eltrombopag, a drug used in the treatment of thrombocytopenia (abnormally low platelet count) for severe aplastic anemia. Synonyms: 3'-{(2Z)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-methoxy-3-biphenylcarboxylic acid; Methoxy Eltrombopag. CAS No. 1437383-35-1. Molecular formula: C26H24N4O4. Mole weight: 456.49. | |
| (Z)-3-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid | (Z)-3-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: (Z)-3-((2'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid. CAS No. 1821386-21-3. Molecular formula: C22H18N4O4. Mole weight: 402.40. | |
| Z-360 | Z-360 is a selective and orally available 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Synonyms: Z-360; Z 360; Z360; Nastorazepide; 3-[[(3R)-1-cyclohexyl-5-(3,3-dimethyl-2-oxobutyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]carbamoylamino]benzoic acid. Grades: > 98%. CAS No. 209219-38-5. Molecular formula: C29H36N4O5. Mole weight: 520.63. | |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing. Synonyms: Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-; 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-; (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol; 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280; trans-4-Hydroxytamoxifen; trans-Hydroxytamoxifen. Grades: ≥98% by HPLC. CAS No. 68047-06-3. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| (Z)-9-Dodecen-1-ol acetate | Synonyms: (Z)-9-Dodecenyl acetate; 9Z-Dodecenyl acetate; (Z)-Dodec-9-en-1-yl acetate; cis-9-Dodecenyl acetate; 9-Dodecen-1-ol, 1-acetate, (9Z)-; (Z)-1-Acetoxy-9-dodecene; cis-9-Dodecen-1-ol acetate; cis-9-Dodecen-1-yl acetate; (9Z)-Dodecen-1-ol Acetate; (Z)-9-Dodecen-1-yl Acetate; Eupoewit; Grapemone. Grades: ≥90%. CAS No. 16974-11-1. Molecular formula: C14H26O2. Mole weight: 226.36. | |
| (Z)-9-Hexadecenal | Synonyms: (9Z)-9-Hexadecenal. Grades: 95%. CAS No. 56219-04-6. Molecular formula: C16H30O. Mole weight: 238.41. | |
| Zafirlukast | Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of certain natural substances that cause swelling and tightening of the airways. Synonyms: ICI-204219; ICI204219; ICI 204219; ICI-204,219; ICI 204,219; ICI204,219; Zafirlukast; brand names Accolate, Accoleit, and Vanticon. Grades: >98%. CAS No. 107753-78-6. Molecular formula: C31H33N3O6S. Mole weight: 575.68. | |
| Zamaporvint | Zamaporvint is an orally active and selective inhibitor of Wnt. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Synonyms: RXC004; RXC-004; 5-Methyl-N-(5-(2-pyrazinyl)-2-pyridinyl)-4-(2-(trifluoromethyl)-4-pyridinyl)-1H-imidazole-1-acetamide. CAS No. 1900754-56-4. Molecular formula: C21H16F3N7O. Mole weight: 439.39. | |
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