BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SRT1720 hydrochloride | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3. Synonyms: SRT1720 HCl; SRT1720; N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide hydrochloride. Grades: >98%. CAS No. 1001645-58-4. Molecular formula: C25H23N7OS.HCl. Mole weight: 506.02. |  |
| SRT2104 (GSK2245840) | SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Synonyms: SRT2104; SRT 2104; SRT-2104; GSK2245840; GSK-2245840; GSK 2245840. Grades: >98%. CAS No. 1093403-33-8. Molecular formula: C26H24N6O2S2. Mole weight: 516.64. | |
| (S,S)-Formoterol | . Uses: Antiasthmatic. Synonyms: Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [S-(R*,R*)]-; N- [2-Hydroxy-5- [ (S) -1-hydroxy-2- [ [ (S) -2- (4-methoxyphenyl) -1-methylethyl] amino] ethyl] phenyl] formamide. Grades: > 95%. CAS No. 67346-48-9. Molecular formula: C19H24N2O4. Mole weight: 344.41. | |
| (S,S)-Hydroxy Bupropion | (S,S)-Hydroxy Bupropion is the (S,S) Enantiomer metabolite of Bupropion, an antidepressant. Synonyms: (2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; Radafaxine; (2S-cis)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; (+)-(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; GW 353162. Grades: > 95%. CAS No. 192374-14-4. Molecular formula: C13H18ClNO2. Mole weight: 255.75. | |
| S, S-Isovalganciclovir Impurity | S, S-Isovalganciclovir Impurity is an impurity of Valganciclovir. Synonyms: (S,S)-Iso Valganciclovir Hydrochloride; (2S)-3-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-L-valine 2-Hydroxypropyl Ester Hydrochloride. Grades: > 95%. CAS No. 1401562-13-7. Molecular formula: C14H23N6O5Cl. Mole weight: 390.83. | |
| (S,S)-Palonosetron Diethylamide Dihydrochloride | (S,S)-Palonosetron Diethylamide Dihydrochloride is an intermediate in the synthesis of Palonosetron, which is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Molecular formula: C23H37Cl2N3O. Mole weight: 442.46. | |
| (S,S,S)-(3,5-Dioxa-4-phosphacyclohepa[2,1-a:3,4-a']dinaphthalen-4-yl)bis(1-phenylethyl)amine | (S,S,S)-(3,5-Dioxa-4-phosphacyclohepa[2,1-a:3,4-a']dinaphthalen-4-yl)bis(1-phenylethyl)amine (CAS# 209482-27-9) is a reagent in the stereoselective preparation of fulvestrant, a mediacton for breast cancer in postmenopausal woman. Synonyms: S-(3,5-Dioxa-4-Phospha-Cyclohepta[2,1-A:3,4-A']Dinaphthalen-4-yl)Bis[(1S)-1-Phenylethyl]amine; (S)-1,1'-Binaphthyl-2,2'-diyl bis[(1S)-1-phenylethyl]phosphoramidite; (11bS)-N,N-Bis[(1S)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine. Grades: ≥95%. CAS No. 209482-27-9. Molecular formula: C36H30NO2P. Mole weight: 539.60. | |
| (S)-Tedizolid | (S)-Tedizolid is an isomer of Tedizolid, an antibacterial oxazolidinone drug effective against gram-positive species. Synonyms: (S)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one. Grades: >98%. CAS No. 1431699-67-0. Molecular formula: C17H15FN6O3. Mole weight: 370.34. | |
| (S)-tert-Butyl 5-(((R)-1-(tert-Butoxy)-3-mercapto-1-oxopropan-2-yl)amino)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoate | (S)-tert-Butyl 5-(((R)-1-(tert-Butoxy)-3-mercapto-1-oxopropan-2-yl)amino)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoate is an intermediate in the synthesis of L-γ-Glutamyl-(S)-Allyl-Cysteine, which is an extract from garlic used in the production of inflammatory mediators. Synonyms: 2-Methyl-2-propanyl (2S)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-5-({(2R)-1-[(2-methyl-2-propanyl)oxy]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoate. CAS No. 2112809-06-8. Molecular formula: C21H38N2O7S. Mole weight: 462.60. | |
| (S)-tert-Butyl 5-(((R)-3-(Allylthio)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoate | (S)-tert-Butyl 5-(((R)-3-(Allylthio)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoate is an intermediate in the synthesis of L-γ-Glutamyl-(S)-Allyl-Cysteine, which is an extract from garlic used in the production of inflammatory mediators. Synonyms: (6S,11R)-2,2-Dimethyl-4,9-dioxo-3-oxa-13-thia-5,10-diazahexadec-15-ene-6,11-dicarboxylate bis(2-methyl-2-propanyl); Bis(2-methyl-2-propanyl) (6S,11R)-2,2-dimethyl-4,9-dioxo-3-oxa-13-thia-5,10-diazahexadec-15-ene-6,11-dicarboxylate. Molecular formula: C24H42N2O7S. Mole weight: 502.66. | |
| STK16-IN-1 | STK16-IN-1, a pyrrolonaphthyridinone compound, only potently inhibited STK16 (relative activity remaining 0.65%) and mTOR (relative activity remaining 0.4%) at a concentration of 10 μM. Synonyms: STK16-IN-1; STK16 IN 1; STK16IN1; JWC-029; JWC 029; JWC029; 1-(4-fluoro-3-methylphenyl)-7H-pyrrolo[2,3-h][1,6]naphthyridin-2-one. CAS No. 1223001-53-3. Molecular formula: C17H12FN3O. Mole weight: 293.3. | |
| STM2457 | STM2457 is a potent and selective METTL3 inhibitor. It is used for the research of acute myeloid leukaemia (AML). Synonyms: STM2457; STM 2457. CAS No. 2499663-01-1. Molecular formula: C25H28N6O2. Mole weight: 444.54. | |
| S-(Trichlorovinyl)-L-cysteine | S-(Trichlorovinyl)-L-cysteine is an intermediate in the synthesis of metabolites of Perchloroethene (PER). Synonyms: S-(1,2,2-Trichlorovinyl)-L-cysteine; S-(Trichloroethenyl)-L-cysteine; L-3-(Trichlorovinylthio)-alanine; S-(1,2,2-Trichloroethenyl)-L-cysteine. Grades: > 95%. CAS No. 98025-31-1. Molecular formula: C5H6Cl3NO2S. Mole weight: 250.53. | |
| (S)-Trolox | (S)-Trolox is used in the synthesis of vitamin E analogs. Synonyms: (2S)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic Acid; (-)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic Acid; (S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid; (S)-(-)-Trolox. Grades: ≥95%. CAS No. 53174-06-4. Molecular formula: C14H18O4. Mole weight: 250.29. | |
| SU 3327 | SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM) with selectivity over p38 MAPK and Akt. SU 3327 inhibits the interaction between JNK and JIP (IC50 = 239 nM). Synonyms: SU 3327; SU3327; SU-3327; 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine. Grades: ≥99% by HPLC. CAS No. 40045-50-9. Molecular formula: C5H3N5O2S3. Mole weight: 261.3. | |
| SU 4312 | SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 = 0.8 and 19.4 μM, respectively) wirth selectivity over EGFR and c-Src tyrosine kinases. Synonyms: SU4312; SU-4312; 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-; 2-Indolinone, 3-[p-(dimethylamino)benzylidene]-; 3-(4-Dimethylaminobenzylidenyl)-2-indolinone; 3-[[4-(Dimethylamino)phenyl]methylidene]-2,3-dihydro-1H-indol-2-one; DMBI; NSC 86429. Grades: ≥95%. CAS No. 5812-7-7. Molecular formula: C17H16N2O. Mole weight: 264.33. | |
| SU 4942 | SU 4942 is a modulator of tyrosine kinase signal transduction, targeting VEGF and ECGF. Synonyms: SU 4942; SU-4942; SU4942. 3-(4-Bromobenzylidene)indoline-2-one. CAS No. 76086-99-2. Molecular formula: C15H10BrNO. Mole weight: 300.155. | |
| SU 5201 | SU 5201 is an inhibitor of IL-2 production. Synonyms: (3Z)-3-[(3,4-Dichlorophenyl)methylidene]-1H-indol-2-one; NSC 247030; NSC-247030; NSC247030; SU 5201; SU5201; SU-5201. CAS No. 114727-43-4. Molecular formula: C15H9Cl2NO. Mole weight: 290.143. | |
| SU 5205 | SU5205 is a VEGFR2 inhibitor. Synonyms: 3-(4-fluorobenzylidene)indolin-2-one; SU 5205; SU-5205; SU5205. CAS No. 3476-86-6. Molecular formula: C15H10FNO. Mole weight: 239.249. | |
| SU 5214 | SU 5214 is a modulator of tyrosine kinase signal transduction. Synonyms: SU 5214; SU5214; SU-5214; (3Z)-3-o-Anisylideneoxindole; 3-(2-Methoxy-benzylidene)-3H-indol-2-ol; (3Z)-3-[(2-methoxyphenyl)methylidene]-1H-indol-2-one. CAS No. 186611-04-1. Molecular formula: C16H13NO2. Mole weight: 251.285. | |
| SU5408 | A potent, selective and cell-permeable inhibitor of VEGFR2 kinase(IC50= 70 nM) with little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 μM). Synonyms: SU-5408; SU 5408; SU5408; ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate; VEGFR2 Kinase Inhibitor I; IN1018. CAS No. 15966-93-5. Molecular formula: C18H18N2O3. Mole weight: 310.35. | |
| SU 5614 | SU4984 is a FLT3 inhibitor that induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. It also exhibits inhibitory effects on C-KIT, VEGFR, and PDGFR&beta. Synonyms: SU5614; SU 5614; SU5614; (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one. CAS No. 1055412-47-9. Molecular formula: C15H13ClN2O. Mole weight: 272.73. | |
| Succinylacetone | Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase that inhibits heme biosynthesis. It is used as a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. Uses: Enzyme inhibitors. Synonyms: NSC 174804; NSC174804; NSC-174804; 4,6-Dioxoheptanoic acid; Succinyl acetone; Heptanoic acid, 4,6-dioxo-. CAS No. 51568-18-4. Molecular formula: C7H10O4. Mole weight: 158.153. | |
| Sucrose dilaurate | Sucrose dilaurate is an essential substance in the biomedical realm, takeing up a pivotal role as an emulsifier and stabilizer within drug formulations. Its profound significance lies in its efficacy to enhance drug solubility and bioavailability. Synonyms: [(2S,3S,4R,5R)-3-dodecanoyloxy-4-hydroxy-5-(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyldodecanoate. Grades: 95%. CAS No. 25915-57-5. Molecular formula: C36H66O13. Mole weight: 706.9. | |
| Sufugolix | Sufugolix, also known as TAK-013, is a highly potent, non-peptide and orally available luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.1 nM. Sufugolix was under development to treat endometriosis and uterine leiomyoma and undergone testing in a phase II clinical study in both of these indications, but was subsequently discontinued. Synonyms: 1-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea; 5-(N-benzyl-N-methylaminomethyl)-1--(2,6-difluorobenzyl)-6-(4-(3-methoxyureido)phenyl)-3-phenylthieno(2,3-d)pyrimidine-2,4(1H,3H)-dione; Sufugolix; TAK-013; TAK013; TAK 013. CAS No. 308831-61-0. Molecular formula: C36H31F2N5O4S. Mole weight: 667.72. | |
| Sugammadex-1 | Sugammadex-1 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Molecular formula: C48H72O32I8. Mole weight: 2176.3. | |
| Sugammadex-R12 | Sugammadex-R12 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Molecular formula: C73H106Na8O48S8. Mole weight: 2192.03. | |
| Sugammadex-R18 | Sugammadex-R18 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Molecular formula: C145H208Na16O96S16. Mole weight: 4368.01. | |
| Sugammadex-R4 | Sugammadex-R4 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Synonyms: Org198958-2. Molecular formula: C72H104Na8O49S8. Mole weight: 2194. | |
| Sugammadex-R5 | Sugammadex-R5 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Synonyms: Org199425-1. Molecular formula: C72H104Na8O49S8. Mole weight: 2194. | |
| Sugammadex-R6 | Sugammadex-R6 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Synonyms: Org199074-1. Molecular formula: C72H104Na8O48S9. Mole weight: 2210.07. | |
| Sugammadex-R7 | Sugammadex-R7 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex. Synonyms: Org19339-1. Molecular formula: C69H101Na7O46S8. Mole weight: 2083.96. | |
| Sugammadex sodium | Sugammadex, a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery, is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. Synonyms: γ-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-, sodium salt (1:8); γ-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-, octasodium salt; 6-Per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt; Org 25969; Org25969; Org-25969; Sugammadex sodium salt. Grades: ≥95%. CAS No. 343306-79-6. Molecular formula: C72H104Na8O48S8. Mole weight: 2178.01. | |
| Sulfometuron methyl | Sulfometuron methyl acts as an acetolactate synthase inhibitor, a herbicide, and an active antibacterial agent. Sulfometuron methyl is a substituted pyrimide compound for proteomics research. Synonyms: Benzoic acid, 2-[[[[ (4, 6-dimethyl-2-pyrimidinyl) amino]carbonyl]amino]sulfonyl]-, methyl ester; Curavial; DPX-5648; DPX5648; DPX 5648; Oust; Oust XP; SMM; Sulfomethuron-methyl; Sulfometuron methyl ester; Methyl-2- ( ( ( (4, 6-dimethyl-2-pyrimidinyl) amino) carbonyl) sulfonyl) benzoate; Benzoic acid, o-((3-(4,6-dimethyl-2-pyrimidinyl)ureido)sulfonyl)-, methyl ester. Grades: ≥95%. CAS No. 74222-97-2. Molecular formula: C15H16N4O5S. Mole weight: 364.38. | |
| Sulindac Sulfone | exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive biotransformation including irreversible oxidation to sulindac sulfone. Approximately, one half of an administered dose of sulindac is eliminated through the urine, mostly as the conjugated sulfone metabolite. Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid; (E)-2-(5-Fluoro-2-methyl-1-(4-(methylsulfonyl)benzylidene)-1H-inden-3-yl)acetic acid. Grades: > 95%. CAS No. 59864-04-9. Molecular formula: C20H17FO4S. Mole weight: 372.41. | |
| SUN11602 | SUN11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor. In primary cultures of rat cerebrocortical neurons, SUN11602 and bFGF prevented glutamate-induced neuronal death. Synonyms: SUN11602; SUN-11602; SUN 11602. 4-[[4-[[2-(4-amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide. Grades: >98%. CAS No. 704869-38-5. Molecular formula: C26H37N5O2. Mole weight: 451.615. | |
| Sunitinib | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Uses: Angiogenesis inhibitors; antineoplastic agents. Synonyms: SU11248; SU 11248; SU-11248. Grades: >98%. CAS No. 557795-19-4. Molecular formula: C22H27FN4O2. Mole weight: 398.47. | |
| Sunitinib Impurity G | One of the impurities of Sunitinib, which is a receptor tyrosine kinases inhibitor. Synonyms: N,N-Didesethyl Sunitinib Hydrochloride; N,N-Didesethyl Sunitinib HCl. Grades: > 95%. CAS No. 1217216-61-9. Molecular formula: C18H19FN4O2 HCl. Mole weight: 378.83. | |
| Sutezolid | Sutezolid, also called as PNU-100480, is an oxazolidinone antibacterial compound to reach Phase-II clinical research for Tuberculosis. Synonyms: N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamidePF-02341272; PF02341272; PF 02341272; PNU-100480; PNU 100480; PNU100480; U-100480; U 100480; U100480; Sutezolid.168828-58-8. Grades: 95%. CAS No. 168828-58-8. Molecular formula: C16H20FN3O3S. Mole weight: 353.41. | |
| (S)-Viloxazine Hydrochloride | The S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant. Uses: The (s)-isomer of. Synonyms: (2S)-2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride. CAS No. 56287-61-7. Molecular formula: C13H20ClNO3. Mole weight: 273.76. | |
| T0901317 | T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice. Synonyms: T 0901317; T-0901317; TO-901317; TO901317; N- (2, 2, 2-trifluoroethyl) -N-[4-[2, 2, 2-trifluoro-1-hydroxy-1- (trifluoromethyl) ethyl]phenyl]benzenesulfonamide; T-1317. Grades: >98%. CAS No. 293754-55-9. Molecular formula: C17H12F9NO3S. Mole weight: 481.33. | |
| T863 | T-863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. It causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice. Synonyms: DGAT-1 inhibitor; DGAT 1 inhibitor; T863; T-863; T 863. Grades: >98%. CAS No. 701232-20-4. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| Tacalcitol monohydrate | Tacalcitol is a vitamin D analogue that promotes normal bone development by regulating calcium. It modulates immunological and inflammatory processes and induces nerve growth factor production in epidermal keratinocytes. Synonyms: 1,24(R)-Dihydroxyvitamin D3, monohydrate. Grades: >98%. CAS No. 93129-94-3. Molecular formula: C27H46O4. Mole weight: 434.65. | |
| Tacrolimus regioisomer | Tacrolimus regioisomer is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (4E, 11E)-10-Allyl-7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 26, 22, 28, 28a-hexadecahydro-7, 21-dihydroxy-3-(4-hydroxy-3-methoxycyclohexyl)-16, 18-dimethoxy-4, 6, 12, 14, 20-pentamethyl-17, 21-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclopentacosine-1, 9, 22, 23(6H, 25H)-tetrone. Molecular formula: C44H69NO12. Mole weight: 804.03. | |
| Tacrolimus System Suitability Mixture | It is a mixture of tacrolimus, ascomycin and tacrolimus 8-propyl analog. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone mix. with (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Ethyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone mix. with (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-{(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-8-propyl-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone. Molecular formula: C44H69NO12.C43H69NO12.C44H71NO12. Mole weight: 2402.10. | |
| Tacrolimus USP Related Compound A | Tacrolimus USP Related Compound A is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: USP Tacrolimus Related Compound A; (E)-8-Ethyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-Hexadecahydro-5, 19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone. Grades: ≥95%. Molecular formula: C43H69NO12. Mole weight: 792.01. | |
| Tadalafil EP Impurity I | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatmen of erectile dysfunction. Synonyms: Tadalafil Spiro-oxindole Impurity; (8a'R)-6'-(1,3-Benzodioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-6'H-spiro[indole-3,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(1H)-trione. Grades: > 95%. CAS No. 1795790-92-9. Molecular formula: C22H19N3O5. Mole weight: 405.41. | |
| Tadalafil Impurity B | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatmen of erectile dysfunction. Synonyms: (6R, 12aS)-6-(1, 3-benzodioxal-5yl)-2-methyl-2, 3, 6, 7, 12, 12a-hexahydropyrazino[1', 2':1, 6]pyrido[3, 4-b]-1, 4-dione. Grades: > 95%. CAS No. 951661-82-8. Molecular formula: C20H19N3O3. Mole weight: 349.39. | |
| Tadalafil Impurity D | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatmen of erectile dysfunction. Synonyms: (6bR)-12-(1,3-Benzodioxol-5-yl)-12a-hydroxy-8-methyl-6a,6b,8,9,12,12a-hexahydropyrazino[1?,2?:1,2]-pyrrolo[3,4-c]quinoline-6,7,10(5H)-trione. Grades: > 95%. CAS No. 951661-81-7. Molecular formula: C22H20ClN3O4. Mole weight: 425.88. | |
| Tafamidis | Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Synonyms: Fx-1006A; Vyndaqel. Grades: >98%. CAS No. 594839-88-0. Molecular formula: C14H7Cl2NO3. Mole weight: 308.12. | |
| Tafluprost | Tafluprost is a novel prostanoid analogue that activates Prostaglandin Receptor. It is used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula. Synonyms: AFP-168, AFP-168, AFP-168, MK-2452, MK2452, MK 2452, Taflotan; Zioptan; AFP-168; Saflutan; propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate. Grades: ≥ 98%. CAS No. 209860-87-7. Molecular formula: C25H34F2O5. Mole weight: 452.539. | |
| Tafluprost ethyl amide | Synonyms: Taflpostamide; (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]-N-ethylhept-5-enamide. CAS No. 1185851-52-8. Molecular formula: C24H33F2NO4. Mole weight: 437.5. | |
| TAK-243 | TAK-243, a pyrazolopyrimidine derivative, has been found to be an Ubiquitin-protein ligase inhibitor and was just finished the Phase-I trial against solid tumors. Synonyms: TAK-243; TAK 243; TAK243; MLN7243; MLN-7243; MLN 7243; AOB87172; AOB-87172; AOB 87172. Grades: 98%. CAS No. 1450833-55-2. Molecular formula: C19H20F3N5O5S2. Mole weight: 519.51. | |
| TAK-448 | TAK-448 is a KISS1R protein agonist as a oligopeptide analog of kisspeptin. In animal model, TAK-448 can stimulate LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. Phase II clinical trials for the treatment of Prostate cancer was discontinued. In Dec 2016, Takeda terminated a phase II trial in Hypogonadism (In adults, In the elderly) in USA because the study did not meet the primary endpoints. Uses: Hypogonadism;prostate cancer. Synonyms: MVT-602; Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2; RVT-602; RVT 602; TAK 448; RVT602; TAK448; N-acetyl-D-tyrosyl-(4R)-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl-2-azaglycyl-L-leucyl-N5-(imino(methylamino)methyl)-L-ornithyl-L-Tryptophanamide; Istaroxime; (2S,5S,8S,14S,17S,20S)-20-[({(2S,4R)-1-[(2R)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]-4-hydroxy-2-pyrrolidinyl}carbonyl)amino]-14-benzyl-17-(1-hydroxyethyl)-2-(1H-indol-3-ylmethyl)-8-isobutyl-5-[3-(N'-methylcarbamimidamido)propyl]-4,7,10,13,16,19-hexaoxo-3,6,9,11,12,15,18-heptaazadocosane-1,22-diamide. Grades: 98%. CAS No. 1234319-68-6. Molecular formula: C58H80N16O14. Mole weight: 1225.36. | |
| TAK-875 | TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy. Synonyms: TAK875; TAK 875; Fasiglifam; 3-Benzofuranacetic acid, 6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-, (3S)-; (3S)-6-[[2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid; (+)-TAK 875; (3S)-6-([2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl]methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid. Grades: >98%. CAS No. 1000413-72-8. Molecular formula: C29H32O7S. Mole weight: 524.63. | |
| Talabostat mesylate | Talabostat mesylate is the orally bioavailable mesylate salt of an amino boronic dipeptide with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. Uses: For research used only. Synonyms: (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid (1:1); PT-100; PT100; PT 100; D05989; D-05989; D 05989; Val-boro-pro; Talabostat. Grades: 98%. CAS No. 150080-09-4. Molecular formula: C10H23BN2O6S. Mole weight: 310.17. | |
| Talampicillin Hydrochloride | The hydrochloride salt form of Talampicillin, which is a penicillin-like antibiotic and used as the predrug of ampicillin. Uses: Anti-bacterial agents. Synonyms: (3-oxo-1H-2-benzofuran-1-yl) (2S,5R,6R)-6-[(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride. Grades: > 95%. CAS No. 39878-70-1. Molecular formula: C24H23N3O6S. HCl. Mole weight: 517.98. | |
| Talarozole | Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases including psoriasis and acne. Synonyms: N-[4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine; Rambazole; R 115866; R-115866; R115866. Grades: ≥95%. CAS No. 201410-53-9. Molecular formula: C21H23N5S. Mole weight: 377.50. | |
| (±)-Talinolol | (±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Synonyms: Cordanum; Talinolol. Grades: ≥95%. CAS No. 57460-41-0. Molecular formula: C20H33N3O3. Mole weight: 363.5. | |
| Talopram Hydrochloride | Talopram hydrochloride is a potent and selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM) that has selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Talopram is considered as an antidepressant. Uses: Antidepressant. Synonyms: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine Hydrochloride; N,3,3-Trimethyl-1-phenyl-1-phthalanpropylamine Hydrochloride; 1-(3-Methylaminopropyl)-1-phenyl-3,3-dimethylphthalane Hydrochloride; Lu 3-010 Hydrochloride; NSC 104350; Talopram HCl; Phtalapromine hydrochloride. Grades: 98%. CAS No. 7013-41-4. Molecular formula: C20H25NO.HCl. Mole weight: 331.88. | |
| Tamoxifen Citrate | Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding, leading to a reduction in DNA synthesis and cellular response to estrogen. Uses: Antineoplastic agent. Synonyms: ICI 46474 Citrate; ICI46474 Citrate; ICI-46474 Citrate; Tamoxifen (Citrate); Zitazonium; Istubal; Tamoxifencitrate. Grades: >98%. CAS No. 54965-24-1. Molecular formula: C26H29NO.C6H8O7. Mole weight: 563.64. | |
| Tanzisertib | Tanzisertib, also known as CC-930, is a potent, selective, and orally active JNK inhibitor with potential antifibrotic activity. CC-930 entered Phase I clinical trials. Tanzisertib may have potential use for prevention and treatment of dermal fibrosis. Selective inhibition of JNK by CC-930 exerted potent antifibrotic effects in vitro and in different models in vivo. JNK might thus be a novel molecular target for the treatment of fibrosis in SSc. Synonyms: CC930, CC-930, CC 930, Tanzisertib, JNK-930, JNKI-1, JNK930, JNKI1, JNK 930, JNKI 1. Grades: >98%. CAS No. 899805-25-5. Molecular formula: C21H23F3N6O2. Mole weight: 448.45. | |
| Tariquidar | Tariquidar, also known as XR9576, is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. Synonyms: XR 9576; XR9576; XR-9576; D06008. Grades: >98%. CAS No. 206873-63-4. Molecular formula: C38H38N4O6. Mole weight: 646.744. | |
| TAS0728 | TAS0728 is a potent and seletive HER2 inhibitor possibly used for the treatment of various cancers. It covalently binds to HER2 at C805 and selectively inhibits its kinase activity. Synonyms: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide. CAS No. 2088323-16-2. Molecular formula: C26H32N8O3. Mole weight: 504.6. | |
| TAS4464 | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Synonyms: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-. CAS No. 1848959-10-3. Molecular formula: C21H23FN6O6S. Mole weight: 506.5. | |
| Tasimelteon | Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep-wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved. Uses: Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. it helps to correct the circadian rhythm disorder often seen in patients who are visually impaired. Synonyms: BMS-214,778; BMS-214778; BMS214778; BMS 214778. VEC-162; VEC162; VEC 162. Trade name: Hetlioz. Grades: ≥ 99.0%. CAS No. 609799-22-6. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
| TAT peptide | TAT peptide, derived from the transactivator of transcription (TAT) of human immunodeficiency virus, is a cell penetrating peptide (GRKKRRQRRRPQ). Synonyms: TAT-peptide. Grades: 98%. Molecular formula: C65H124N34O15. Mole weight: 1621.91. | |
| Tauro-obeticholic acid | Tauro-obeticholic acid is an active metabolite of obeticholic acid, a farnesoid X receptor (FXR) agonist. Synonyms: Obeticholic acid taurine conjugate; Tauro 6-ethylchenodeoxycholic acid. Grades: ≥95%. CAS No. 863239-61-6. Molecular formula: C28H49NO6S. Mole weight: 527.76. | |
| Taurultam | Taurultam is a compound with antibacterial activity. It has shown inhibitory effect on cell proliferation and cell adhesion in angiogenesis. Synonyms: 1,2,4-Thiadiazinane 1,1-dioxide. Grades: >95%. CAS No. 38668-01-8. Molecular formula: C3H8N2O2S. Mole weight: 136.169. | |
| Tazarotene Thiochromane Dimer | Tazarotene Thiochromane Dimer is an impurity of Tazarotene, which is a third-generation prescription topical retinoid used to treat plaque psoriasis, acne, photoaged and photodamaged skin. Synonyms: 6,6'-(1,3-Butadiyne-1,4-diyl)bis[3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran]; Methyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; 6,6'-(1,3-Butadiyne-1,4-diyl)bis(4,4-dimethylthiochromane); Tazarotene Impurity 5. Grades: 98%. CAS No. 1010805-73-8. Molecular formula: C26H26S2. Mole weight: 402.61. | |
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