BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Hydroxythio Vardenafil | An impurity of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: 2-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazine-4(1H)-thione; 4-[[3-(1,4-Dihydro-5-methyl-7-propyl-4-thioxoimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol. CAS No. 912576-30-8. Molecular formula: C23H32N6O4S2. Mole weight: 520.68. |  |
| Hydroxy Timolol | A metabolite of Ticlopidine which is a non-cardioselective beta-blocker and it has no intrinsic sympathomimetic or membrane stabilizing effect. Synonyms: 2-[[(2S)-2-Hydroxy-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]propyl]amino]-2-methyl-1-propanol. Grade: > 95%. Molecular formula: C13H24N4O4S. Mole weight: 332.42. | |
| Hydroxy Tipelukast | One of the impurities of Tipelukast which could be used as an oral anti-inflammatory agent and has been found to exhibit potential activities against non-alcoholic fatty liver disease as a leukotriene receptor antagonist. Synonyms: 4-(3-(3-((4-Acetyl-3-hydroxy-2-propylphenyl)thio)propoxy)-6-(1-hydroxyethyl)-2-propylphenoxy)butanoate. CAS No. 1027597-04-1. Molecular formula: C29H40O7S. Mole weight: 532.70. | |
| Hydroxy Tipelukast-d6 | One of the isotopic labelled impurities of Tipelukast which could be used as an oral anti-inflammatory agent and has been found to exhibit potential activities against non-alcoholic fatty liver disease as a leukotriene receptor antagonist. Synonyms: 4-(3-(3-((4-acetyl-3-hydroxy-2-propylphenyl)thio)propoxy-d6)-6-(1-hydroxyethyl)-2-propylphenoxy)butanoate. Molecular formula: C29H33D6NaO7S. Mole weight: 560.71. | |
| Hydroxy tolbutamide | One of the impurities of Tolbutamide, which is an antidiabetic and often used in veterinary medicine as hypoglycemic agent. Synonyms: N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide; 1-Butyl-3-(p-hydroxymethylphenyl)sulfonylurea; Hydroxytolbutamide; Hydroxymethylcarbutamide. CAS No. 5719-85-7. Molecular formula: C12H18N2O4S. Mole weight: 286.35. | |
| Hydroxy Torsemide | Hydroxy Torsemide is a metabolite of Torsemide, which is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. Synonyms: 4-[[3-(Hydroxymethyl)phenyl]amino]-N-[[(1-methylethyl)amino]carbonyl]-3-pyridinesulfonamide; AC 3534; 3-Pyridinesulfonamide, 4-[[3-(hydroxymethyl)phenyl]amino]-N-[[(1-methylethyl)amino]carbonyl]-; 4-((3-(hydroxymethyl)phenyl)amino)-N-(isopropylcarbamoyl)pyridine-3-sulfonamide; Hydroxytorsemide; 1-[[4-[3-(Hydroxymethyl)anilino]-3-pyridyl]sulfonyl]-3-isopropylurea; 4-[3-(Hydroxymethyl)anilino]-N-[(propan-2-yl)carbamoyl]pyridine-3-sulfonamide; N-(Isopropylcarbamoyl)-4-[3-(hydroxymethyl)phenylamino]-3-pyridinesulfonamide. Grade: ≥95%. CAS No. 99300-68-2. Molecular formula: C16H20N4O4S. Mole weight: 364.42. | |
| Hydroxy Triamterene | Hydroxy Triamterene is a metabolite of Triamterne that is used as a diuretic. Synonyms: 4-Hydroxy Triamterene; 4-(2,4,7-Triamino-6-pteridinyl)phenol; 2,4,7-Triamino-6-(p-hydroxyphenyl)pteridine; p-Hydroxytriamterene. CAS No. 1226-52-4. Molecular formula: C12H11N7O. Mole weight: 269.27. | |
| Hydroxy Triamterene-d4 | Hydroxy Triamterene-d4 is the labelled analogue of Hydroxy Triamterene. Triamterene is an epithelial sodium channel blocker. Synonyms: 4-Hydroxy Triamterene-d4; CTK8F6002; DTXSID50675964; P-Hydroxytriamterene-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 1184977-36-3. Molecular formula: C12H7N7OD4. Mole weight: 273.29. | |
| Hydroxy Triamterene Sulfate-d4 | One of the isotopic labeled form of Hydroxy Triamterene Sulfate, which is a metabolite of Triamterne. Synonyms: 4-Hydroxy Triamterene Sulfate-d4; 4-(2,4,7-Triamino-6-pteridinyl)phenol 1-(Hydrogen Sulfate)-d4. Molecular formula: C12H7D4N7O4S. Mole weight: 352.35. | |
| Hydroxy Triamterene Sulfate Sodium Salt | Hydroxy Triamterene Sulfate Sodium Salt is a metabolite of Triamterne that is used as a diuretic. Synonyms: 4-Hydroxy Triamterene Sulfate, Sodium Salt; 4-(2,4,7-Triamino-6-pteridinyl)phenol 1-(Hydrogen Sulfate) Sodium; Hydroxytriamterene Sulfate Ester Sodium; p-Hydroxytriamterene Sulfate Sodium. CAS No. 73756-87-3. Molecular formula: C12H10N7O4S. Na. Mole weight: 371.31. | |
| Hydroxy Triclabendazole | Hydroxy Triclabendazole is a metabolite of Triclabendazole. Triclabendazole is an anthelmintic used for liver fiukes. Synonyms: Triclabendazole Sulfoxide; 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole. CAS No. 100648-13-3. Molecular formula: C14H9Cl3N2O2S. Mole weight: 375.66. | |
| Hydroxy Vardenafil | Hydroxy Vardenafil is a derivative of Vardenafil as a PDE5 inhibitor. Synonyms: 2-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one; 4-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo [5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol. CAS No. 224785-98-2. Molecular formula: C23H32N6O5S. Mole weight: 504.61. | |
| Hydroxy Varenicline | Hydroxy varenicline is a metabolite of varenicline, an nAChR agonist. Varenicline is a prescription medication used for the treatment of smoking addiction. Synonyms: 2-Hydroxyvarenicline. Grade: ≥95%. CAS No. 357424-21-6. Molecular formula: C13H13N3O. Mole weight: 227.3. | |
| Hydroxy Varenicline N-Trifluoroacetic Acid Salt | Hydroxy Varenicline N-Trifluoroacetic Acid Salt is a Varenicline metabolite. Varenicline is a partial agonist of nicotinic receptor used for smoking cessation. It reduces both the desire for and the pleasure of cigarettes. Synonyms: Varenicline Impurity 2; 1,6,7,8,9,10-Hexahydro-8-(trifluoroacetyl)-6,10-methano-2H-pyrazino[2,3-h][3]benzazepin-2-one. CAS No. 357426-10-9. Molecular formula: C15H12F3N3O2. Mole weight: 323.28. | |
| Hydroxy Vildagliptin | Hydroxy Vildagliptin is an impurity of Vildagliptin. It is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Synonyms: (S)-1-(((1R,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)glycyl)pyrrolidine-2-carbonitrile. Molecular formula: C17H25N3O3. Mole weight: 319.41. | |
| Hydroxywybutosine | Hydroxywybutosine is a crucial compound in the biomedical industry for treating viral infections, particularly those caused by the Herpes Simplex Virus (HSV). This antiviral drug inhibits the replication of HSV by targeting essential enzymes within infected cells. With its potent antiviral activity, Hydroxywybutosine proves to be a promising therapeutic option for managing viral infections, offering potential relief and improved patient outcomes. Synonyms: 3H-Imidazo[1,2-a]purine-7-butanoic acid, 4,9-dihydro-β-hydroxy-α-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-β-D-ribofuranosyl-, methyl ester, (αS)-; Methyl (αS)-4,9-dihydro-β-hydroxy-α-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-β-D-ribofuranosyl-3H-imidazo[1,2-a]purine-7-butanoate; Methyl (2S)-4-(3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4,6-dimethyl-9-oxo-4,9-dihydro-3H-imidazo[1,2-a]purin-7-yl)-3-hydroxy-2-((methoxycarbonyl)amino)butanoate. CAS No. 945684-11-7. Molecular formula: C21H28N6O10. Mole weight: 524.49. | |
| Hydroxyzine Impurity 2 | Hydroxyzine Impurity 2 is a first-generation antihistamine of the diphenylmethane and piperazine classes which is used as a sedative/hypnotic drug in Europe and South Africa. Synonyms: 2-[2-(2-{4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)ethoxy]ethanol; Etodroxizine; 2-[2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethoxy]ethanol; 8-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]-3,6-dioxa-1-octanol; Hydrochlorbenzethy. Grade: > 95%. CAS No. 17692-34-1. Molecular formula: C23H31ClN2O3. Mole weight: 418.97. | |
| Hydroxy Ziprasidone | An impurity of Ziprasidone, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Synonyms: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]-1-hydroxyethyl]-6-chloro-1,3-dihydro-2H-indol-2-one. CAS No. 884305-08-2. Molecular formula: C21H21ClN4O2S. Mole weight: 428.94. | |
| Hygromycin A | Hygromycin A is a natural antibiotic found in Streptomyces species. Hygromycin A selectively kills the bacteria that cause Lyme disease. Synonyms: Totomycin; Antibiotic WS-1627B; 4-(5-Acetyl-3,4-dihydroxy-2-tetrahydrofuranyloxy)-3-hydroxy-alpha-methyl-N-(2,3,6-trihydroxy-4,5-methylendioxycyclohexyl)zimtsaeureamid. Grade: 95%. CAS No. 6379-56-2. Molecular formula: C23H29NO12. Mole weight: 511.48. | |
| Hyoscine Butylbromide EP Impurity D (Mixture of Diastereomers) | An impurity of N-Butylscopolammonium bromide. N-Butylscopolammonium bromide is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. Synonyms: (1R,2R,4S,5S,7s,9R)-7-(((S)-3-Hydroxy-2-phenylpropanoyl)oxy)-9-methyl-9-propyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium Bromide; N-Desbutyl-N-propylscopolammonium Bromide; Propylhyoscine bromide. Grade: >95%. Molecular formula: C20H28BrNO4. Mole weight: 426.34. | |
| Hyoscine Butylbromide Impurity E HCl | An impurity of N-Butylscopolammonium bromide. N-Butylscopolammonium bromide is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. Synonyms: N-Butylhyoscine HCl; [7(S)-(1α2β,4β,5α,7β)]-α-(Hydroxymethyl)benzeneacetic Acid; 9-Butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester Hydrochloride; 8-Butyl-6β,7β-epoxy-1αH,5αH-nortropan-3α-ol (-)-Tropate Ester Hydrochloride; N-Butylnorhyoscine Hydrochloride; N-Butylnorscopolamine Hydrochloride; N-Butyl Nor Scopolamine Hydrochloride; Benzeneacetic acid, α-(hydroxymethyl)-, 9-butyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrochloride, [7(S)-(1α,2β,4β,5α,7β)]-; 1αH,5αH-Nortropan-3α-ol, 8-butyl-6β,7β-epoxy-, (-)-tropate (ester), hydrochloride (1:1). Grade: >95%. CAS No. 22235-98-9. Molecular formula: C20H27NO4.HCl. Mole weight: 381.89. | |
| Hyoscine Butylbromide Impurity G | A metabolite of N-Butylscopolammonium bromide. N-Butylscopolammonium bromide is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. Synonyms: (1α,2β,4β,5α,7β)-9-Butyl-9-methyl-7-[(1-oxo-2-phenyl-2-propenyl)oxy]-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide; 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-butyl-9-methyl-7-[(1-oxo-2-phenyl-2-propenyl)oxy]-, bromide, (1α,2β,4β,5α,7β)-; Apobuscopan; (1R,2R,4S,5S,7s,9r)-9-butyl-9-methyl-7-[(2-phenylprop-2-enoyl)oxy]-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide; apo-N-Butylhyoscine bromide. Grade: >95%. CAS No. 92714-23-3. Molecular formula: C21H28BrNO3. Mole weight: 422.36. | |
| Hyperforin dicyclohexylammonium salt | Hyperforin is a principal ingredient of Hypericum perforatum (St. John's wort). Hyperforin activates TRPC6 channel to inhibit the reuptake of serotonin, suggesting its potential use as an antidepressant. It also exhibits antibacterial effects. Synonyms: Hyp-DCHA; Hyperforin-DCHA; Hyperforin DCHA. Grade: 95%. CAS No. 238074-03-8. Molecular formula: C47H75NO4. Mole weight: 718.10. | |
| Hypericin | It is a natural antidepressant produced by the strain of Hypericium perforatum (plant extract). It is an anti-retroviral agent and protein kinaze-C inhibitor. Uses: Antineoplastic and antitumor. Synonyms: Cyclo-Werol; Cyclosan; Hyperflav; Hypericum red; NSC 407313; Mycoporphyrin; 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone; 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione. Grade: >98%. CAS No. 548-04-9. Molecular formula: C30H16O8. Mole weight: 504.45. | |
| Hypericin-d10 | Hypericin-d10 is the isotope labelled analog of Hypericin. Synonyms: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione-d10; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione P-conformer-d10; Cyclo-Werol-d10; Cyclosan-d10; Hyperflav-d10; Hypericum Red-d10. Grade: > 95%. Molecular formula: C30H6O8D10. Mole weight: 514.52. | |
| Hypotaurine | Hypotaurine is an endogenous inhibitory amino acid for glycine receptor (GlyR). It acts as an antioxidant and a protective agent under physiological conditions. Uses: Antioxidants. Synonyms: 2-aminoethanesulfinic acid. CAS No. 300-84-5. Molecular formula: C2H7NO2S. Mole weight: 109.15. | |
| Hypothemycin | Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. This inhibition was partially reversed by exogenous IL-2 indicating that it is not due to non-specific toxicity. Hypothemycin potently suppressed the production of IL-2 (IC50: 9 nM) but affected IL-2-induced proliferation to a lesser extent (IC50: 194 nM). Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. By contrast, it markedly enhanced the production of IL-4, IL-5 and IL-13. These effects were seen both at the mRNA and protein secretion levels. Analysis of the effect of hypothemycin on CD69 induction suggested that it disrupts calcineurin-independent rather than calcineurin-dependent signaling. Furthermore, hypothemycin was able to inhibit the phosphorylation of ERK1/2 induced by PMA treatment of T cells. Therefore, hypothemycin represents an inhibitor of T cell activation with a novel mode of action and unique modulatory activity on cytokine production. Synonyms: Hypothemycin. CAS No. 76958-67-3. Molecular formula: C19H22O8. Mole weight: 378.38. | |
| Hypoxanthine-[13C,15N2] | Hypoxanthine-[13C,15N2]. Uses: A labelled metabolite of purine in cocaine addiction. Synonyms: Hypoxanthine-15N2,13C; 6-Oxopurine-13C,15N2; 1,9-Dihydro-6H-purin-6-one-13C,15N2; 3H-Purin-6-ol-13C,15N2; 6-Hydroxy-1H-purine-13C,15N2; 6-Hydroxypurine-13C,15N2; Hypoxanthine enol-13C,15N2; Sarcine-13C,15N2; Sarkin-13C,15N2. Grade: ≥98%. CAS No. 244769-71-9. Molecular formula: C4[13C]H4N2[15N]2O. Mole weight: 139.09. | |
| Hypromellose | Hypromellose is a methyl and hydroxypropyl mixed ether of cellulose. It is utilized as artificial tears to prevent conjunctival and corneal damage due to impaired lacrimal secretions. Synonyms: hydroxypropyl methylcellulose. CAS No. 8063-82-9. | |
| HyT36 | HyT36 is a hydrophobic inducer of the degradation of stabilized proteins. Synonyms: HyT36; 1323151-45-6; (R)-4-((3R,5R,7R)-Adamantan-1-yl)-N-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)-2-methylbutanamide; SCHEMBL16145936; MS-27953; HY-141676; CS-0198451; F90276. Grade: >98%. CAS No. 1323151-45-6. Molecular formula: C25H44ClNO3. Mole weight: 442.08. | |
| HZ-1157 | HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. Synonyms: HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II; 5-tert-butoxyquinazoline-2,4-diamine; 5-(tert-Butoxy)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-. Grade: 98.75%. CAS No. 1009734-33-1. Molecular formula: C12H16N4O. Mole weight: 232.287. | |
| HZ52 | HZ52 is a novel reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. HZ52 was shown to prevent carrageenan-induced pleurisy accompanied by reduced LTB(4) levels and protected mice (10 mg·kg?¹, i.p.) against PAF-induced shock. Synonyms: HZ-52; HZ 52; 2-[4-Chloro-6-(4-phenylanilino)pyrimidin-2-yl]sulfanyloctanoic acid. Grade: ≥98%. CAS No. 1077626-51-7. Molecular formula: C24H26ClN3O2S. Mole weight: 456. | |
| I-191 | I-191 is a potent antagonist of protease activated receptor 2 (PAR2). Synonyms: 4-[8-Tert-Butyl-6-(4-Fluorophenyl)Imidazo[1,2-B]Pyridazine-2-Carbonyl]-3,3-Dimethylpiperazin-2-One; PAR2 Antagonist I-191; SCHEMBL16598387; GTPL10268; BCP32684. Grade: 98%. CAS No. 1690172-25-8. Molecular formula: C23H26FN5O2. Mole weight: 423.5. | |
| I2906 | Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). Synonyms: I 2906; I-2906. Grade:>98%. CAS No. 331963-29-2. Molecular formula: C25H37N3O4. Mole weight: 443.58. | |
| I-37 hydrochloride | I-37 hydrochloride is an SOS1 inhibitor. Synonyms: Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-, hydrochloride (1:1); (R)-2-methyl-4-((1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)-6-(1-methylcyclopropyl)pyrido[4,3-d]pyrimidin-7(6H)-one hydrochloride; US10829487, Example I-37 hydrochloride; I-37 hydrochloride; 2-Methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]pyrido[4,3-d]pyrimidin-7(6H)-one hydrochloride; I-37 free base. Grade: ≥95%. CAS No. 2929868-91-5. Molecular formula: C22H24ClF3N4O. Mole weight: 452.90. | |
| I3MT-3 | I3MT-3 is a potent, selective, and cell-membrane permeable inhibitor of 3-mercaptopyruvate sulfurtransferase (3MST) with IC50 of 2.7 μM. I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes. Synonyms: HMPSNE; 6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one. CAS No. 459420-09-8. Molecular formula: C17H14N2O2S. Mole weight: 310.37. | |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Synonyms: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole. Grade: ≥98%. CAS No. 1570496-34-2. Molecular formula: C25H25F3N6O4S. Mole weight: 562.57. | |
| IACS-010759 hydrochloride | IACS-010759 hydrochloride is a potent inhibitor of complex I of OXPHOS. IACS-010759 hydrochloride inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research. Synonyms: IACS-010759 HCl; IACS-10759 hydrochloride. Grade: 99%. CAS No. 1807523-99-4. Molecular formula: C25H26ClF3N6O4S. Mole weight: 599.03. | |
| IACS-13909 | IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses signaling through the MAPK pathway. IACS-13909 potently impeded proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver. Synonyms: BBP-398. CAS No. 2160546-07-4. Molecular formula: C17H18Cl2N6. Mole weight: 377.27. | |
| IACS-8779 | IACS-8779 is a highly potent agonist of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. IACS-8779 shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds. Synonyms: SCHEMBL23046679; 2243079-26-5; AKOS040733407. Grade: >98%. CAS No. 2243079-26-5. Molecular formula: C21H25N9O10P2S2. Mole weight: 689.56. | |
| IACS-8803 | IACS-8803 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. Compared to one of the clinical benchmark compounds, it shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma. Synonyms: CHEMBL4596454; SCHEMBL22930678; SCHEMBL23710564; 2095690-70-1; AKOS040733408. Grade: >98%. CAS No. 2095690-70-1. Molecular formula: C20H23FN10O9P2S2. Mole weight: 692.53. | |
| IACS-8803 diammonium | IACS-8803 diammonium is a highly potent cyclic dinucleotide, which shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds. Synonyms: IACS-8803 (diammonium). Grade: 98%. Molecular formula: C20H29FN12O9P2S2. Mole weight: 726.60. | |
| IACS-8803 disodium | IACS-8803 disodium is one of the STING agonists. Synonyms: IACS-8803 (disodium). Grade: 98%. CAS No. 2243079-36-7. Molecular formula: C20H23FN10Na2O9P2S2. Mole weight: 738.51. | |
| IACS-9571 | IACS-9571, a benzoimidazol derivative, has been found to be a TRIM24 and BRPF1 inhibitor and could be probably significant in anticancer studies. Synonyms: N-(6-(3-(4-(dimethylamino)butoxy)-5-propoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-3,4-dimethoxybenzenesulfonamide; IACS-9571; IACS 9571; IACS9571; IACS 009571-001-4. Grade: 98%. CAS No. 1800477-30-8. Molecular formula: C32H42N4O8S. Mole weight: 642.77. | |
| IACS-9571 hydrochloride | IACS-9571 hydrochloride is a potent and selective TRIM24 and BRPF1 inhibitor, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively. Synonyms: ASIS-P040 hydrochloride; N-(6-{3-[4-(Dimethylamino)butoxy]-5-propoxyphenoxy}-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-3,4-dimethoxybenzenesulfonamide hydrochloride (1:1); Benzenesulfonamide, N-[6-[3-[4-(dimethylamino)butoxy]-5-propoxyphenoxy]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl]-3,4-dimethoxy-, hydrochloride (1:1). Grade: ≥95%. CAS No. 2319611-93-1. Molecular formula: C32H43ClN4O8S. Mole weight: 679.22. | |
| Iadademstat dihydrochloride | Iadademstat dihydrochloride is a selective and irreversible inhibitor of lysine (K)-specific demethylase 1A (KDM1A/LSD1). Synonyms: ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride; trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride; trans-N-[(1R,2S)-2-Phenylcyclopropyl]-1,4-cyclohexanediamine dihydrochloride; 1,4-Cyclohexanediamine, N1-[(1R,2S)-2-phenylcyclopropyl]-, trans-, hydrochloride (1:2). Grade: ≥98%. CAS No. 1431303-72-8. Molecular formula: C15H24Cl2N2. Mole weight: 303.27. | |
| IAXO-102 | IAXO-102 is a TLR4 antagonist that modulates non-hematopoietic TLR4 proinflammatory signalling and inhibits experimental abdominal aortic aneurysm (AAA) development. Synonyms: IAXO-102; 1115270-63-7; CID 25222900; (2R,3R,4S,5R,6S)-2-(aminomethyl)-6-methoxy-4,5-di(tetradecoxy)oxan-3-ol; CHEMBL493017; SCHEMBL20239315; EX-A3691; AKOS037648519; BS-14387; HY-125171; CS-0089755; D70080; Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-|A-D-glucopyranoside. CAS No. 1115270-63-7. Molecular formula: C35H71NO5. Mole weight: 585.94. | |
| Ibalizumab | Ibalizumab is a humanized anti-CD4 monoclonal antibody approved for the treatment of HIV-1 infection. Ibalizumab blocks HIV-1 entry into CD4 cells while preserving normal immune function. Synonyms: TMB-355; TNX-355. CAS No. 680188-33-4. Molecular formula: C14H9I3O4. Mole weight: 621.93. | |
| Ibandronate Impurity A | Ibandronate Impurity A. Grade: > 95%. CAS No. 905808-25-5. Molecular formula: C8H21NO7P2. Mole weight: 305.21. | |
| Ibandronate Sodium | Ibandronate sodium is a potent bisphosphonate drug developed by Hoffman La Roche and used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels). Ibandronate is indicated for the treatment and prevention of osteoporosis in post-menopausal women. In May 2003, the U.S. Food and Drug Administration (FDA) approved Ibandronate as a daily treatment for post-menopausal osteoporosis. Ibandronate is efficacious for the prevention of metastasis-related bone fractures in multiple myeloma, breast cancer, and certain other cancers. Uses: Bone density conservation agents. Synonyms: Boniva Sodium; Bondronat Sodium; Bonviva Sodium. Grade: >98%. CAS No. 138844-81-2. Molecular formula: C9H22NNaO7P2. Mole weight: 341.21. | |
| Ibandronate Sodium Monohydrate | Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner. Synonyms: BM-21.0955. Grade:>98%. CAS No. 138926-19-9. Molecular formula: C9H23NO7P2.Na.H2O. Mole weight: 360.23. | |
| Ibandronic Acid | Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. Synonyms: P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid; [1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid; BPH 24; Ibandronate; 1-Hydroxy-3-(methylpentylamino)propylidene]diphosphonic Acid. Grade: >98%. CAS No. 114084-78-5. Molecular formula: C9H23NO7P2. Mole weight: 319.23. | |
| Ibandronic Acid Impurity HCl | Ibandronic Acid Impurity HCl is an intermediate in the preparation of Ibandronic Acid. Synonyms: 3-(N-Methyl-N-pentylamino)propionic Acid Hydrochloride; N-Methyl-N-pentyl-β-alanine Hydrochloride; Ibanic Acid Hydrochloride; Ibandronate Related Compound A. Grade: > 95%. CAS No. 625120-81-2. Molecular formula: C9H20NO2Cl. Mole weight: 209.72. | |
| Ibandronic Acid N-(2-Methylbutyl) Impurity | Ibandronic Acid N-(2-Methylbutyl) Impurity. Grade: > 95%. Molecular formula: C9H23NO7P2. Mole weight: 319.23. | |
| IBC 293 | IBC 293, a cell-permeable niacin triazolo derivative, is a potent and highly selective agonist for human orphan G-protein-coupled receptor GPR109b/HM74 expressed in adipocytes with EC50 value of 400 nM. It is selective for GPR109B over niacin receptor GPR109A and β-adrenergic receptor. It inhibits cAMP elevation induced by isoproterenol and forskolin in freshly isolated human adipocytes and GPR109b-expressing CHO cells. It also inhibits forskolin-stimulated cAMP release in Chinese hamster ovary cells. It also inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes. It may be relevant to atherosclerosis and dyslipidemia. Synonyms: IBC 293; IBC293; IBC-293. 1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid; 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid. Grade: ≥99% by HPLC. CAS No. 306935-41-1. Molecular formula: C10H11N3O2. Mole weight: 205.22. | |
| Iberdomide | Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 nM. It has antitumor and immunomodulatory activities. Synonyms: (3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione; CC-220; CC220; CC 220; Iberdomide. CAS No. 1323403-33-3. Molecular formula: C25H27N3O5. Mole weight: 449.5. | |
| Iberin | Iberin, a naturally occurring member of isothiocyanate family found in cruciferous plants, inhibits cell survival (IC50 = 2.3 μM in HL60 cell). Synonyms: 1-isothiocyanato-3-methylsulfinylpropane; 1-isothiocyanato-3-(methylsulfinyl)propane; 1-isothiocyanato-3-(methylsulphinyl)propane; iberin; IMSP. CAS No. 505-44-2. Molecular formula: C5H9NOS2. Mole weight: 163.26. | |
| Iberiotoxin trifluoroacetate salt | Iberiotoxin is a 37-amino acid peptide toxin purified from the scorpion Buthus tamulus. It acts as a blocker of high conductance Ca(2+)-activated K+ channels at nanomolar concentrations. Grade: ≥95%. CAS No. 182897-30-9. Mole weight: 4230.9. | |
| I-BET151 | I-BET151 is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. It was shown to induce early cell cycle arrest and apoptosis in human and mouse MLL-fusion leukemia cell lines. Synonyms: GSK1210151A; 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one. Grade: >98%. CAS No. 1300031-49-5. Molecular formula: C23H21N5O3. Mole weight: 415.453. | |
| I-BET 151 dihydrochloride | The hydrochloride salt form of I-BET 151, which has been found to be a BET bromodomain inhibitor and exhibit activities against human and murine MLL-fusion leukaemic cell lines. Synonyms: I-BET 151 dihydrochloride; I BET 151 dihydrochloride; IBET 151 dihydrochloride; IBET151 dihydrochloride; 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1883545-47-8. Molecular formula: C23H21N5O3.2HCl. Mole weight: 488.37. | |
| I-BET567 | I-BET567 is a potent and orally active pan-BET candidate inhibitor with pIC50s of 6.9 and 7.2 against BRD4 BD1 and BD2, respectively. It has been shown to be effective in mouse models of oncology and inflammation. Synonyms: 6-Quinolinecarboxamide, 1-acetyl-4-[(5-chloro-2-pyrimidinyl)amino]-1,2,3,4-tetrahydro-2-methyl-, (2S,4R)-. Grade: ≥95%. CAS No. 1887237-54-8. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
| Ibezapolstat hydrochloride | Ibezapolstat hydrochloride is an active DNA polymerase IIIC inhibitor. Ibezapolstat is used in the research of C. difficile infection (CDI). Synonyms: 6H-Purin-6-one, 2-(((3,4-dichlorophenyl)methyl)amino)-1,7-dihydro-7-(2-(4-morpholinyl)ethyl)-, hydrochloride (1:1). Grade: >98.0%. CAS No. 1275582-98-3. Molecular formula: C18H21Cl3N6O2. Mole weight: 459.76. | |
| Ibiglustat | Ibiglustat is a selective Glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. In Oct 2016, Genzyme completed a phase II trial in Fabry's disease (Treatment-naïve) in USA, Czech Republic, France, Poland, Russia and the UK. Phase-II clinical trials in Gaucher's disease in USA is on-going. Uses: Fabry's disease; gaucher's disease. Synonyms: Venglustat; GZ-402671; GZ402671; GZ 402671; SSAR402671; SAR-402671; SAR 402671; Genz-682452-AA; GZ-452; Genz-682452; GZ 452; Genz 682452; GZ452; (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate. Grade: 98%. CAS No. 1401090-53-6. Molecular formula: C20H24FN3O2S. Mole weight: 389.49. | |
| Ibiglustat succinate | Ibiglustat succinate is a glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. Synonyms: Venglustat succinate; Ibiglustat L-malate. CAS No. 1629063-78-0. Molecular formula: C24H30FN3O7S. Mole weight: 523.6. | |
| Ibipinabant | Ibipinabant is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. Uses: Cannabinoid receptor cb1 antagonists. Synonyms: BMS-646256; BMS646256; BMS 646256; SLV-319; SLV 319; SLV319; JD-5001; JD 5001; JD5001; Ibipinabant.3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4S-phenyl-1H-pyrazole-1-carboximidamide. Grade: ≥98%. CAS No. 464213-10-3. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.40. | |
| IBMX | IBMX is an inhibitor of cAMP and cGMP phosphodiesterases. IBMX was shown to promote differentiation of 3T3-L1 cells in combination with insulin and dexamethasone. It also induces neural transdifferentiation of mesenchymal stem cells (MSCs) through downregulation of the NRSF. Uses: Phosphodiesterase inhibitors. Synonyms: 3-Isobutyl-1-methylxanthine; isobutylmethylxanthine; 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione. Grade: >98%. CAS No. 28822-58-4. Molecular formula: C10H14N4O2. Mole weight: 222.24. | |
| Ibodutant | Ibodutant is a tachykinin receptor antagonist. It selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. It is a candidate drug for irritable bowel syndrome diarrhea. It was developed by The Menarini Group. It is in the clinical phase III. Uses: Ibodutant is a candidate drug for irritable bowel syndrome diarrhea. Synonyms: MEN-15596; MEN 15596; MEN15596; Ibodutant 6-Methyl-N-[1-[[(2R)-1-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide; (R)-6-methyl-N-(1-((1-oxo-3-phenyl-1-(((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidi. Grade: 98%. CAS No. 522664-63-7. Molecular formula: C37H48N4O4S. Mole weight: 644.87. | |
| I-BOP | I-BOP is a potent TP receptor agonist that induces platelet aggregation and vascular smooth muscle contraction. Synonyms: (Z)-7-[(1S,2R,3R,4R)-3-[(E,3R)-3-hydroxy-4-(4-iodophenoxy)but-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid. Grade: ≥95%. CAS No. 128719-90-4. Molecular formula: C23H29IO5. Mole weight: 512.4. | |
| Ibopamine | Ibopamine, the prodrug of epinine, is a sympathomimetic drug used in ophthalmology. It induces mydriasis. It acts as an agonist on Dopamine receptor D1 and α-adrenergic receptors and has been studied for the treatment of congestive heart failure. Synonyms: 4-(2-(methylamino)ethyl)-1,2-phenylene bis(2-methylpropanoate); 4-(2-(Methylamino)ethyl)-o-phenylene diisobutyrate; SB-7505; Propanoic acid, 2-methyl-, 4-(2-(methylamino)ethyl)-1,2-phenylene ester; Diisobutyric acid 4-[2-(methylamino)ethyl]-o-phenylene ester; 2-Methylpropanoic Acid 4-[2-(Methylamino)ethyl]-1,2-phenylene Ester. Grade: ≥95%. CAS No. 66195-31-1. Molecular formula: C17H25NO4. Mole weight: 307.38. | |
| Ibopamine Hydrochloride | Ibopamine Hydrochloride, the prodrug of epinine, is a sympathomimetic drug used in ophthalmology. It induces mydriasis. It acts as an agonist on Dopamine receptor D1 and α-adrenergic receptors and has been studied for the treatment of congestive heart failure. Synonyms: 2-Methylpropanoic Acid 1,1'-[4-[2-(Methylamino)ethyl]-1,2-phenylene] Ester Hydrochloride; 3,4-Di-O-isobutyrylepinine Hydrochloride; Inopamil; Scandine. Grade: ≥95%. CAS No. 75011-65-3. Molecular formula: C17H26ClNO4. Mole weight: 343.85. | |
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