BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| HPK1-IN-13 | HPK1-IN-13 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 64. HPK1-IN-13 has the potential for the research of HPK1 related diseases. Uses: It is being investigated for its potential use in the treatment of cancer and other diseases. CAS No. 2734168-30-8. Molecular formula: C25H24FN5O2. Mole weight: 445.49. |  |
| HPK1-IN-14 | HPK1-IN-14 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 79. HPK1-IN-14 has the potential for the research of HPK1 related diseases. Synonyms: N-(2-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-4-pyrimidinamine. CAS No. 2734168-45-5. Molecular formula: C24H23FN6O2. Mole weight: 446.48. | |
| HPK1-IN-15 | HPK1-IN-15 is a potent and selective inhibitor of HPK1 extracted from patent WO2018049200A1, compound 50. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. Synonyms: N-(3-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-4-pyrimidinamine. CAS No. 2201098-03-3. Molecular formula: C24H21ClF3N5. Mole weight: 471.91. | |
| HPK1-IN-16 | HPK1-IN-16 is a potent and selective inhibitor of HPK1 extracted from patent WO2019051199A1, compound 39. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2294965-95-8. Molecular formula: C28H27FN4O. Mole weight: 454.54. | |
| HPK1-IN-17 | HPK1-IN-17 is a potent and selective inhibitor of HPK1 extracted from patent WO2019238067A1, compound 73. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2403600-07-5. Molecular formula: C26H28N6O. Mole weight: 440.54. | |
| HPK1-IN-18 | HPK1-IN-18 is a potent and selective inhibitor of HPK1 extracted from patent WO2019238067A1, compound 1. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2403598-42-3. Molecular formula: C24H24N4. Mole weight: 368.47. | |
| HPK1-IN-19 | HPK1-IN-19 is a potent and selective inhibitor of HPK1 extracted from patent WO2018102366A1 compound I-47. CAS No. 2227609-33-6. Molecular formula: C27H32N7O2P. Mole weight: 517.56. | |
| HPK1-IN-2 | HPK1-IN-2 is an orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1), Lck and Flt3 with IC50 of <0.05 μM, <0.5 μM and <0.05 μM, respectively. CAS No. 2056122-11-1. Molecular formula: C19H20N6OS. Mole weight: 380.47. | |
| HPK1-IN-20 | HPK1-IN-20 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor extracted from patent WO2020235902A1 compound 106. CAS No. 2561490-78-4. Molecular formula: C26H28N6O2. Mole weight: 456.54. | |
| HPK1-IN-3 | HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. Synonyms: HPK1-IN-3; 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; CHEMBL4878586; BDBM552521; WO2022098809, Example 4-8; MS-29115; HY-138568; CS-0159070; 4-((2-fluoro-6-(trifluoromethyl)phenyl)amino)-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidine-5-carboxamide; YK1. Grade: 98%. Molecular formula: C23H22F4N6O2. Mole weight: 490.45. | |
| HPK1-IN-4 | HPK1-IN-4 is a HPK1 (MAPK41) inhibitor with an IC50 of 0.061 nM. Synonyms: HPK1-IN-4; 2739844-28-9; CHEMBL4865305; EX-A5129; BDBM50569672; AKOS040758005; MS-27782; HY-138569; CS-0159071. Grade: 99%. CAS No. 2739844-28-9. Molecular formula: C23H26N6O3. Mole weight: 434.49. | |
| HPK1-IN-7 | HPK1-IN-7 is a potent, orally active HPK1 inhibitor with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). Synonyms: (S)-5-((4-((2-Hydroxy-1-phenylethyl)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one. Grade: 99%. CAS No. 2320462-65-3. Molecular formula: C24H22N6O4. Mole weight: 458.48. | |
| HPK1-IN-8 | HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1. CAS No. 1214561-09-7. Molecular formula: C19H17FN6O2S. Mole weight: 412.44. | |
| HPN-01 | HPN-01 is a potent and selective inhibitor of IKK, with pIC50s of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. It shows greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src and VEGFR-2. Synonyms: [1,1':3',1''-Terphenyl]-5'-carboxamide, 4'-amino-4''-(aminosulfonyl)-4-chloro-; 4'-Amino-4-chloro-4''-sulfamoyl-1,1':3',1''-terphenyl-5'-carboxamide; 2-Amino-3-(4-sulfamoylphenyl)-5-(4-chlorophenyl)benzamide; 4'-amino-4-chloro-4''-sulfamoyl-[1,1'; 3',1'']terphenyl-5'-carboxylic acid amide. Grade: ≥98%. CAS No. 928655-63-4. Molecular formula: C19H16ClN3O3S. Mole weight: 401.87. | |
| HPOB | HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs. Synonyms: 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide. Grade: >98%. CAS No. 1429651-50-2. Molecular formula: C17H18N2O4. Mole weight: 314.34. | |
| HPP854 | HPP854, developed by High Point Pharmaceuticals, is a small molecule BACE1 protein inhibitor. Phase 1. Synonyms: HPP854; TTP-854. | |
| HPV16 E7 (86-93) acetate | HPV16 E7 86-93 is a human leukocyte antigen (HLA)-A2-restricted HPV16 E7 derived peptide that has immunogenicity in cervical cancer. Synonyms: HPV16 E7 (86-93) acetate; AKOS040764039. Molecular formula: C39H70N8O12S. Mole weight: 875.08. | |
| HQ-415 | HQ-415 is a relevant bioactive metal chelators(EC50=15 μM). Uses: A relevant bioactive metal chelators. Synonyms: 7-[(3-Ethoxy-4-methoxyphenyl)-[(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol; HQ-415; HQ 415; HQ415. Grade: ≥95%. CAS No. 430462-93-4. Molecular formula: C25H25N3O3. Mole weight: 415.48. | |
| HQL 79 | HQL 79 is a selective inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). HQL 79 is potentially used as an antihistamine that exerts antiallergic and antiasthmatic properties in vivo. Synonyms: HQL-79; HQL 79; HQL79. 4-(Diphenylmethoxy)-1-(3-2H-tetrazol-5-yl)propyl]-piperidine; Cc-704. Grade: ≥99% by HPLC. CAS No. 162641-16-9. Molecular formula: C22H27N5O. Mole weight: 377.48. | |
| HS014 TFA | HS014 TFA is a potent and selective antagonist of melanocortin-4 (MC4) receptor, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. Grade: 98%. Molecular formula: C73H95F3N20O19S2. Mole weight: 1677.78. | |
| HS024 TFA | HS024 is a selective antagonist of MC4 receptor, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. Grade: 99%. Molecular formula: C60H80F3N19O12S2. Mole weight: 1380.52. | |
| HS-10296 | HS-10296 is an EGFR tyrosine kinase inhibitor. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Synonyms: HS 10296; HS10296. CAS No. 1899921-05-1. Molecular formula: C30H35N7O2. Mole weight: 525.64. | |
| HS-10352 Impurity D | HS-10352 Impurity D is an impurity of HS-10352, a selective PI3Kα inhibitor with inhibitory effects on the proliferation of cancer tumor cell lines harboring PIK3CA mutations. Synonyms: (R)-2-((R)-3-Aminobutanamido)propanoic acid; H-bAla(3R-Me)-D-Ala-OH. CAS No. 2276229-34-4. Molecular formula: C7H14N2O3. Mole weight: 174.20. | |
| HS-131 | HS-131 is a near-infrared dye tethered Hsp90 inhibitor capable of detecting oncogene-driven breast cancers, including a variety of different human breast cancer molecular subtypes. Synonyms: 4-((E)-2-((2Z,4E)-3-(4-(21-((2-carbamoyl-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)-6,9,12,15,18-pentaoxa-2-azahenicosyl)phenyl)-5-(3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium-2-yl)penta-2,4-dien-1-ylidene)-3,3-dimethylindolin-1-yl)butane-1-sulfonate; 3H-Indolium, 2-[(1E,3Z,5E)-3-[4-[21-[[2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)phenyl]amino]-6,9,12,15,18-pentaoxa-2-azaheneicos-1-yl]phenyl]-5-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-3,3-dimethyl-1-(4-sulfobutyl)-, inner. CAS No. 2084850-40-6. Molecular formula: C71H95N7O13S2. Mole weight: 1318.68. | |
| HS-1371 | HS-1371 is a novel RIP3 kinase inhibitor with IC50 value of 20.8 nM. It binds to RIP3 in an ATP-competitive and time-independent manner in vitro, and inhibits RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. Synonyms: HS 1371; HS1371; 4-(4-Methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline. CAS No. 2158197-70-5. Molecular formula: C24H24N4O. Mole weight: 384.47. | |
| HS-173 | HS-173 is a potent and selective PI3Kα inhibitor displaying anticancer activity. HS-173 was shown to induce apoptosis via arresting the cell cycle at the G2/M phase. It also decreases angiogenesis induced by VEGF. Synonyms: Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate; HS173; HS 173; HS-173. Grade: 98%. CAS No. 1276110-06-5. Molecular formula: C21H18N4O4S. Mole weight: 422.459. | |
| HS-1793 | HS-1793 is a resveratrol analog. It downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Synonyms: 4-(6-hydroxy-2-naphthyl)-1,3-benzenediol. Grade: >98%. CAS No. 927885-00-5. Molecular formula: C16H12O3. Mole weight: 252.26. | |
| HS-243 | HS-243 is a highly potent inhibitor of interleukin-1 receptor-associated kinase (IRAK). HS-243 specifically inhibits intracellular IRAKs without TAK1 inhibition. Synonyms: HS 243; HS243. CAS No. 848249-10-5. Molecular formula: C17H16N4O3. Mole weight: 324.33. | |
| HS-27 | HS-27 is a fluorescently linked Hsp90 inhibitor with diagnostic and therapeutic potential in triple-negative breast cancer. Grade: 98%. CAS No. 1562024-11-6. Molecular formula: C52H60N6O12S. Mole weight: 993.1. | |
| HS271 | HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50 = 7.2 μM), with superior enzymatic and cellular activity, as well as excellent pharmacokinetic properties. Synonyms: 2-Pyridinecarboxamide, N-[2-[2-(dimethylamino)ethyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-; N-{2-[2-(Dimethylamino)ethyl]-6-(2-hydroxy-2-propanyl)-2H-indazol-5-yl}-6-(trifluoromethyl)-2-pyridinecarboxamide. Grade: ≥95%. CAS No. 2410393-15-4. Molecular formula: C21H24F3N5O2. Mole weight: 435.44. | |
| HS 38 | HS 38 is an ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). It also inhibits PIM3 kinase (IC50 = 200 nM) with no significant effect on Src or Abl kinases. HS 38 regulates programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. Synonyms: HS 38; HS38; HS-38; 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide. Grade: ≥98% by HPLC. CAS No. 1030203-81-6. Molecular formula: C14H12CIN5O2S. Mole weight: 349.8. | |
| HS666 hydrochloride | HS666 is a selective κ opioid receptor partial agonist that activates central κ receptors to produce potent antinociception, displaying pharmacological characteristics of a κ receptor analgesic with reduced liability for aversive effects correlating with its low efficacy in the β-arrestin2 signalling pathway. Synonyms: 3-(2-((Cyclopropylmethyl)(phenethyl)amino)ethyl)phenol hydrochloride. Grade: 99%. CAS No. 1409931-99-2. Molecular formula: C20H25NO.HCl. Mole weight: 331.88. | |
| HSD1590 | HSD1590 is a potent ROCK inhibitor with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. It exhibits single digit nanomolar binding to ROCK (Kds<2 nM). Grade: 99%. CAS No. 2379279-96-4. Molecular formula: C20H18BN3O3. Mole weight: 359.19. | |
| HSF1A | HSF1A is a cell-permeable human heat shock factor protein (HSP1) activator. Synonyms: 4-Ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide. Grade: 99%. CAS No. 1196723-93-9. Molecular formula: C21H19N3O2S2. Mole weight: 409.52. | |
| HSF1B | HSF1B is a human heat shock factor protein (HSF1) activator. Synonyms: N-[2,5-bis(4-chlorophenyl)pyrazol-3-yl]-4-butylbenzamide. Grade: 99%. CAS No. 1196723-95-1. Molecular formula: C26H23Cl2N3O. Mole weight: 464.39. | |
| HSK0935 | HSK0935 is a new class of Glucose Cotransporter 2 (SGLT2) inhibitor, which is for the treatment of Type 2 diabetes research. Synonyms: HSK-0935. CAS No. 1638851-44-1. Molecular formula: C22H25ClO7. Mole weight: 436.88. | |
| HSK16149 | HSK16149 is a voltage-gated calcium channel (VGCC) α2δ subunit selective ligand with analgesic activity in animal models of chronic pain. Synonyms: HSK 16149; HSK-16149; 2-((1S,2S,3R,6S,8S)-2-(aminomethyl)tricyclo[4.2.1.03,8]nonan-2-yl)acetic acid. Grade: ≥95%. CAS No. 2209104-84-5. Molecular formula: C12H19NO2. Mole weight: 209.28. | |
| hSMG-1 inhibitor 11e | hSMG-1 inhibitor 11e is a potent, selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. It shows>900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM). Grade: 99%. CAS No. 1402452-10-1. Molecular formula: C26H27N7O3S. Mole weight: 517.61. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 is an HSP27 inhibitor that can significantly induce abnormal formation of HSP27 dimer and inhibit the production of HSP27 giant polymers, thereby inhibiting the chaperone function of HSP27 and reducing its cellular protective function. It significantly enhances the anti-proliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition. Synonyms: J2; 4H-1-Benzopyran-4-one, 5-hydroxy-2-methyl-7-(2-thiiranylmethoxy)-; 5-Hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one; 5-Hydroxy-2-methyl-7-(2-thiiranylmethoxy)-4H-chromen-4-one. Grade: ≥95%. CAS No. 2133499-85-9. Molecular formula: C13H12O4S. Mole weight: 264.30. | |
| HSP47 inhibitor III | An inhibitor of the collagen-specific chaperone HSP47 with IC50 of 3.1 μM. HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts. Synonyms: CBTC; Methyl 6-chloro-2-oxo-3H-1,2λ4,3-benzodithiazole-4-carboxylate. Grade: 98%. CAS No. 287917-38-8. Molecular formula: C8H6ClNO3S2. Mole weight: 263.72. | |
| HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor that interferes with the formation of functional Hsp70-HOP-Hsp90 machinery, and it inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. Synonyms: HSP70-IN-1; HSP70 IN 1; 2-amino-N-[3-[2-(4-methylpiperazin-1-yl)-4-phenylmethoxypyrimidin-5-yl]sulfanylphenyl]acetamide; SCHEMBL1276103. CAS No. 1268273-90-0. Molecular formula: C24H28N6O2S. Mole weight: 464.58. | |
| Hsp90-Cdc37-IN-1 | Hsp90-Cdc37-IN-1, an Hsp90-Cdc37 interaction disruptor, can inhibit cell migration and reverse drug resistance, with an IC50 of 140 nM. Synonyms: Olean-12-en-29-oic acid, 3-[4-[(6-fluoro-2-benzothiazolyl)amino]-1,4-dioxobutoxy]-11-oxo-, ethyl ester, (3β,20β)-; Ethyl (3β)-3-({4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-4-oxobutanoyl}oxy)-11-oxoolean-12-en-30-oate. Grade: ≥95%. CAS No. 2227303-22-0. Molecular formula: C43H57FN2O6S. Mole weight: 748.99. | |
| HSP990 | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grade: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39. | |
| HSR6071 | HSR60716071, a novel pyrazinecarboxamide derivative, exhibits potent inhibition of the IgE-mediated passive cutaneous anaphylaxis (PCA) in rats on oral administration, and that its inhibition of PCA is at least in part due to the depression of allergic histamine release from mast cells. Synonyms: 6-pyrrolidin-1-yl-N-(2H-tetrazol-5-yl)pyrazine-2-carboxamide; 6-(1-pyrrolidinyl)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide; HSR 6071l; HSR-6071. CAS No. 111374-21-1. Molecular formula: C10H12N8O. Mole weight: 260.26. | |
| HTH-01-015 | HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). Synonyms: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Grade: >98%. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.55. | |
| HTL-001 | HTL-001 is a novel inhibitor of HOX/PBX binding. In mouse models, it inhibited the growth of prostate and breast tumor. Besides, HTL-001 can significantly increase the expression of cFos and DUSP1, which are targets of HXR9. Uses: Anti-prostate and breast tumor. Synonyms: HTL-001; HTL001. | |
| HTL26119 | HTL26119 is a glucagon-like peptide-1 receptor (GLP-1R) antagonist. Synonyms: HTL-26119; HTL 26119. Grade: ≥98% by HPLC. Molecular formula: C28H23Cl3N2O5. Mole weight: 573.85. | |
| HTL-9936 | HTL-9936 is a selective muscarinic M1 receptor agonist. Synonyms: HTL 9936; HTL9936. Grade: 98% by HPLC. CAS No. 1438242-59-1. Molecular formula: C20H35N3O3. Mole weight: 365.5. | |
| HTMT dimaleate | HTMT dimaleate is a histamine H1 and H2 receptor agonist with 4x104 fold activity over histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site except for H1, H2 or H3. Synonyms: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate; Histamine trifluoromethyl toluidide. Grade: ≥99% by HPLC. CAS No. 195867-54-0. Molecular formula: C19H25F3N4O.2C4H4O4. Mole weight: 614.57. | |
| hTrkA-IN-1 | hTrkA-IN-1 is a potent and orally active TrkA kinase inhibitor (IC50 = 1.3 nM), which can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al. (Extracted from patent WO2015175788, compound 2). Synonyms: Urea, N-[(3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)-3-pyrrolidinyl]-N'-[4-methyl-3-(2-methyl-5-pyrimidinyl)-1-phenyl-1H-pyrazol-5-yl]-; 1-((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea; BLN64892. Grade: ≥90%. CAS No. 1824664-89-2. Molecular formula: C29H32FN7O2. Mole weight: 529.61. | |
| HTS01037 | HTS01037, a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM), and is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki= 0.67 μM). Synonyms: HTS01037; HTS 01037; HTS-01037. 4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid; (E)-4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid; 4-{[2-(methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid. CAS No. 682741-29-3. Molecular formula: C14H11NO5S2. Mole weight: 337.37. | |
| H-Type 2-APE-HSA | H-Type 2-APE-HSA. Synonyms: H Type II-APE-HAS. | |
| H Type II-APD-BSA | H Type II-APD-BSA. Synonyms: H Type 2-APD-BSA. | |
| Hu7691 | Hu7691 is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. It also inhibits tumor growth and enables decrease of cutaneous toxicity in mice. CAS No. 2360523-76-6. Molecular formula: C22H22ClF3N4O. Mole weight: 450.88. | |
| Hu7691 free base | Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. It also inhibits tumor growth and enables decrease of cutaneous toxicity in mice. CAS No. 2241232-43-7. Molecular formula: C22H21F3N4O. Mole weight: 414.42. | |
| Huanglongmycin N | Huanglongmycin N is an inhibitor of DNA topoisomerase I with an EC50 of 14 μM. Synonyms: Huanglongmycin N; HY-N10115; CS-0256117. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| HUHS015 | HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. As expected, continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. Synonyms: HUHS015; HUHS 015; HUHS-015. Grade: 0.98. CAS No. 1453097-13-6. Molecular formula: C19H18N4O. Mole weight: 318.37242. | |
| Humanin (human) (trifluoroacetate salt) | Humanin is a micropeptide encoded by the 16S ribosomal RNA gene MT-RNR2 in the mitochondrial genome. Synonyms: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH.TFA; L-methionyl-L-alanyl-L-prolyl-L-arginyl-glycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-L-alanine trifluoroacetic acid. Grade: 95%. Molecular formula: C121H205F3N34O34S2. Mole weight: 2801.3. | |
| Humulone | Humulone, a phloroglucinol derivative with antioxidant activity, inhibits cyclooxygenase-2. Synonyms: (6S)-3,5,6-trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dien-1-one. Grade: > 95%. CAS No. 26472-41-3. Molecular formula: C21H30O5. Mole weight: 362.47. | |
| Huperzine A-d3 | Huperzine A-d3 is a labelled Huperzine A. Huperzine A is a naturally occurring sesquiterpene alkaloid used for the treatment of swelling, fever, blood disorders as well as Alzheimer's disease. Grade: > 95%. Molecular formula: C15H15N2OD3. Mole weight: 245.34. | |
| hVEGF-IN-1 | hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity. Tumor bearing mice treated with hVEGF-IN-1 have an average tumor volume of less than 300 mm. The tumor weight in the presence of hVEGF-IN-1 reduces around 60.1% to a final weight of 0.18 g. No significant change in body weight is observed during the treatment. Synonyms: 1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl. CAS No. 1637443-98-1. Molecular formula: C34H43N7O2. Mole weight: 581.75. | |
| HWL-088 | HWL-088 is a highly potent and orally active agonist of free fatty acid receptor 1 (FFA1/GPR40) with an EC50 of 18.9 nM. HWL-088 improves glucose and lipid metabolism. It has anti-diabetic effects and moderate PPARδ activity with an EC50 of 570.9 nM. Synonyms: 2-(2-fluoro-4-((2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenoxy)acetic acid; {2-Fluoro-4-[(2'-methyl-3-biphenylyl)methoxy]phenoxy}acetic acid; Acetic acid, 2-[2-fluoro-4-[(2'-methyl[1,1'-biphenyl]-3-yl)methoxy]phenoxy]-. Grade: ≥98%. CAS No. 2378617-96-8. Molecular formula: C22H19FO4. Mole weight: 366.38. | |
| HX 531 | HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white and brown pre-adipocyte to white adipocytes, and reduces triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice given a high fat diet. Synonyms: HX 531; HX-531; HX531. 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid. Grade: ≥98% by HPLC. CAS No. 188844-34-0. Molecular formula: C29H29N3O4. Mole weight: 483.56. | |
| HX600 | HX600 is a synthetic agonist for RXR-Nurr1 heterodimer complex. It prevents ischemia-induced neuronal damage. Synonyms: HX-600; HX 600; (Z)-4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid. Grade: 99%. CAS No. 172705-89-4. Molecular formula: C29H30N2O2. Mole weight: 438.56. | |
| HX-603 | HX-603 is a RXR agonist. Synonyms: 4-(7,7,10,10-tetramethyl-5-propyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid; HX-603; HX 603; HX603. Grade: >98%. CAS No. 259228-72-3. Molecular formula: C31H34N2O2. Mole weight: 466.625. | |
| HX 630 | HX 630 is a potent RXR agonist that acts as a retinoid synergist. HX 630 suppresses proliferation of vascular smooth muscle cells (VSMCs) in vivo and in vitro. It was shown to enhance ABCA1 mRNA expression and apoA-I-dependent cellular cholesterol release in differentiated THP-1 cells. Synonyms: HX 630; HX630; HX-630; 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid. Grade: ≥98% by HPLC. CAS No. 188844-52-2. Molecular formula: C28H27NO2S. Mole weight: 441.58. | |
| HY-17542 | HY-17542 is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 μM. Synonyms: PLpro inhibitor 6; (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide; HY 17542; HY17542. Grade: >98%. CAS No. 1093070-14-4. Molecular formula: C22H22N2O2. Mole weight: 346.43. | |
| Hyacinthacine A2 | Hyacinthacine A2 is a remarkable antifungal compound extracted from Hyacinthaceae plants, aiding in studying a myriad of fungal infections, encompassing candidiasand aspergillosis. Molecular formula: C8H15NO3. Mole weight: 173.21. | |
| Hyacinthacine B3 | Hyacinthacine B3 is a potent compound used to study bacterial infections exhibiting antimicrobial activity against a variety of pathogens, including multidrug-resistant strains. Synonyms: Hyacinthacine B3; CHEMBL524631; BDBM50278912; (1S,2R,3R,5R,7R,8R)-3-(hydroxymethyl)-5-methyl-2,3,5,6,7,8-hexahydro-1H-pyrrolizine-1,2,7-triol. Molecular formula: C9H17NO4. Mole weight: 203.24. | |
| Hyaluronate fluorescein - Molecular Weight - 1000kDa | Hyaluronate fluorescein - Molecular Weight - 1000kDa. | |
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