BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Regadenoson | Regadenoson, as a coronary vasodilator it is a selective A2A adenosine receptor agonist in myocardial imaging. Uses: A selective a2a adenosine receptor agonist in myocardial imaging. Synonyms: 1-[6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]-N-methylpyrazole-4-carboxamide CVT 3146 CVT-3146 CVT3146 Lexiscan regadenoson. Grades: >99%. CAS No. 313348-27-5. Molecular formula: C15H18N8O5. Mole weight: 390.35. |  |
| Regorafenib EP Impurity D | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4,4'-(((carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide). CAS No. 2438857-80-6. Molecular formula: C27H22F2N6O5. Mole weight: 548.50. | |
| Regorafenib Hydrochloride | Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1. Synonyms: BAY73-4506 hydrochloride. Grades: >98%. CAS No. 835621-07-3. Molecular formula: C21H16Cl2F4N4O3. Mole weight: 519.28. | |
| Regorafenib Impurity 6 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) -3-fluorophenoxy) -; 4- (4- ( (4-Chloro-3- (trifluoromethyl) phenyl) carbamoylamino) -3-fluoro-phenoxy) pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3- (trifluoromethyl) phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. Grades: > 95%. CAS No. 1187945-05-6. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. | |
| Regorafenib monohydrate | Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Synonyms: BAY 73-4506. Grades: >98%. CAS No. 1019206-88-2. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. | |
| Regorafenib monohydrate impurity B [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 02; 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide. CAS No. 2141961-84-2. Molecular formula: C15H14FN3O3. Mole weight: 303.29. | |
| Regorafenib monohydrate impurity C [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpyridine-2-carboxamide; 4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide. CAS No. 1855006-12-0. Molecular formula: C20H18FN5O3. Mole weight: 395.39. | |
| Regorafenib N-Oxide (M2 Metabolite) | A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-11-9. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. | |
| Relebactam | Relebactam, a diazabicyclooctane derivative, has a broad spectrum inhibitory activity against β-lactamases. It has been studied to be probably effective in the treatment of Gram-negative bacterial infections combinated with Primaxin. Uses: Beta-lactamase inhibitors. Synonyms: MK-7655; MK 7655; MK7655. Grades: 98%. CAS No. 1174018-99-5. Molecular formula: C12H20N4O6S. Mole weight: 348.38. | |
| Remdesivir | Remdesivir, an analog nucleotide inhibitor, with effectively antiviral activity in vitro against various virus, including Ebola virus, Marburg virus, HCoV-NL63, HCoV-OC43, HCoV-229E, Mouse hepatitis virus (MHV), SARS-CoV, MERS-CoV and related bat coronavirus, HKU5, and PDCoV (porcine delta-coronavirus). Remdesivir is also reported to have potential antiviral activity against a 2019 novel coronavirus (called 2019-nCoV, nCoV2019 or COVID-19). Synonyms: GS-5734; 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate. Grades: 99.78%. CAS No. 1809249-37-3. Molecular formula: C27H35N6O8P. Mole weight: 602.59. | |
| Remogliflozin etabonate | Remogliflozin etabonat, pro-drug of remogliflozin, is a SGLT2 inhibitor under development for the treatment of type 2 diabetes. Remogliflozin etabonate is a pro-drug of remogliflozin, inhibits the sodium-glucose transport proteins (SGLT), which are responsible for glucose reabsorption in the kidney. Uses: Sglt2 inhibitor. Synonyms: GSK189075A; GSK-189075A; GSK 189075A; GSK189075; GSK-189075; GSK 189075; Remogliflozin etabonate.beta-D-Glucopyranoside, 5-methyl-4-((4-(1-methylethoxy)phenyl)methyl)-1-(1-methylethyl)-1H-pyrazol-3-yl, 6-(ethyl carbonate). Grades: ≥98%. CAS No. 442201-24-3. Molecular formula: C26H38N2O9. Mole weight: 522.59. | |
| Renzapride | Renzapride is a full 5-HT4 agonist and partial 5-HT3 antagonist. Renzapride has been used for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Uses: Serotonin antagonists. Synonyms: Renzapridum; Benzamide, 4-amino-N-(1R,4S,5R)-1-azabicyclo[3.3.1]non-4-yl-5-chloro-2-methoxy-, rel-. Grades: 95%. CAS No. 112727-80-7. Molecular formula: C16H22ClN3O2. Mole weight: 323.82. | |
| Repotrectinib | TPX-0005 is an orally available and potent ATP-competitive inhibitor of ALK/ROS1/TRK (IC50= 5.3 nM for SRC, IC50= 1.01 nM, 1.26 nM and 1.08 nM for mutant ALKs including WT ALK, ALK G1202R and ALK L1196M, respectively). Synonyms: TPX-0005; TPX 0005; TPX0005. CAS No. 1802220-02-5. Molecular formula: C18H18FN5O2. Mole weight: 355.37. | |
| Resiquimod | Resiquimod is an imidazoquinolinamine and TLR7 agonist with antitumor and antiviral activity. Uses: Resiquimod may be used in immunological and cancer-related cell signaling studies. Synonyms: R-848; R 848; R848; S 28463; S-28463; S28463; 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-(ethoxymethyl)-α,α-dimethyl-; 4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 4-Amino-2-(ethoxymethyl)-1-(2-hydroxyisobutyl)imidazo[4,5-c]quinoline; Resimiquimod. Grades: ≥95%. CAS No. 144875-48-9. Molecular formula: C17H22N4O2. Mole weight: 314.38. | |
| (R)-Esmolol Acid | (R)-Esmolol Acid is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Uses: The r-enantiomer metabolite of esmolol (e668000) in humans. Synonyms: 4-[ (2R) -2-Hydroxy-3-[ (1-methylethyl) amino]propoxy]benzenepropanoic Acid. CAS No. 910651-37-5. Molecular formula: C15H23NO4. Mole weight: 281.35. | |
| (R)-Esmolol Hydrochloride | (R)-Esmolol Hydrochloride is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Uses: The r-enantiomer of esmolol (e668000). Synonyms: 4-[ (2R) -2-Hydroxy-3-[ (1-methylethyl) amino]propoxy]benzenepropanoic Acid Methyl Ester Hydrochloride; (+)-Esmolol Hydrochloride. Grades: >95%. CAS No. 118629-36-0. Molecular formula: C16H25NO4.HCl. Mole weight: 331.83. | |
| Resorufin | Resazurin is a blue dye, itself weakly fluorescent until it is irreversibly reduced to the pink colored and highly red fluorescent resorufin. It can be used as an oxidation-reduction indicator in cell viability assays for both aerobic and anaerobic respiration. Synonyms: 7-Hydroxy-3H-phenoxazin-3-one; Resorufine. Grades: > 95%. CAS No. 635-78-9. Molecular formula: C12H7NO3. Mole weight: 213.19. | |
| RETF-4NA | RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G. Synonyms: acetyl-L-Arg-Glu-Thr-Phe-4-nitroanilide. CAS No. 1160928-63-1. Molecular formula: C32H43N9O10. Mole weight: 713.75. | |
| (R)-ethyl 4-cyano-3-hydroxybutanoate | (R)-ethyl 4-cyano-3-hydroxybutanoate is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester; (R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester; Ethyl (R)-4-Cyano-3-hydroxybutanoate. CAS No. 141942-85-0. Molecular formula: C7H11NO3. Mole weight: 157.17. | |
| (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-59-1. Molecular formula: C25H31NO4. Mole weight: 409.526. | |
| Retinoic Acid 3,3-Dimethyl-2-oxobutyl Ester | A derivative of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: Hydroxypinacolone retinoate; (2E,4E,6E,8E)-3,3-Dimethyl-2-oxobutyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate. Grades: 95%. CAS No. 893412-73-2. Molecular formula: C26H38O3. Mole weight: 398.58. | |
| Revefenacin | Revefenacin, also knownc as TD-4208 and GSK1160724, is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. Synonyms: TD-4208; TD4208; TD 4208; GSK1160724; GSK-1160724; GSK 1160724. Grades: 98%. CAS No. 864750-70-9. Molecular formula: C35H43N5O4. Mole weight: 597.76. | |
| (R)-Fesoterodine Fumarate | Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. Synonyms: SPM 907; SPM907; SPM-907. Grades: >98%. CAS No. 286930-03-8. Molecular formula: C26H37NO3.C4H4O4. Mole weight: 527.65. | |
| R-(-)-Flecainide | A stereoisomer of Flecainide. Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Synonyms: N-[(2R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (R)-Flecainide; (-)-Flecainide. Grades: > 95%. CAS No. 99495-90-6. Molecular formula: C17H20F6N2O3. Mole weight: 414.35. | |
| (R)-Flurbiprofen Axetil | Grades: > 95%. Molecular formula: C19H19FO4. Mole weight: 330.36. | |
| R-Frovatriptan | . Uses: Tryptamines; carbazoles. Synonyms: (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide. Grades: > 95%. CAS No. 158747-02-5. Molecular formula: C14H19N3O. Mole weight: 243.33. | |
| RG7800 | RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 shows excellent pharmacokinetic and in vivo efficacy and has a favorable safety profile. RG7800 can correct alternative splicing of the human. Phase I/II clinical trials for the treatment of Spinal muscular atrophyis on-going. Uses: Spinal muscular atrophy. Synonyms: RG7800; RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247. 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methylpiperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: 98%. CAS No. 1449598-06-4. Molecular formula: C24H28N6O. Mole weight: 416.52. | |
| RGB-286638 Free base | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Synonyms: 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea; RGB 286638; RGB286638. Grades: >98%. CAS No. 784210-88-4. Molecular formula: C29H35N7O4. Mole weight: 545.63. | |
| RGD peptide | RGD peptide is an inhibitor of integrin-ligand interactions. Synonyms: H-Gly-Arg-Gly-Asp-Asn-Pro-OH; RGD peptide (GRGDNP); glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-asparagyl-L-proline; (S)-1-((6S,12S,15S)-1-amino-15-(2-amino-2-oxoethyl)-6-(2-aminoacetamido)-12-(carboxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecane)pyrrolidine-2-carboxylic acid. Grades: 98%. CAS No. 114681-65-1. Molecular formula: C23H38N10O10. Mole weight: 614.61. | |
| RGW 611 | RGW 611 is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa. Nimorazole is being researched for the treatment of head and neck cancer. Synonyms: 4-(2-(4-nitro-1H-imidazol-1-yl)ethyl)morpholine. CAS No. 6497-78-5. Molecular formula: C9H14N4O3. Mole weight: 226.236. | |
| Rhein ether glucuronide | A derivative of Rhein. Rhein is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. Grades: > 95%. Molecular formula: C21H16O12. Mole weight: 460.35. | |
| Rhein monosulfate | A derivative of Rhein. Rhein is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. Grades: > 95%. Molecular formula: C15H8O9S. Mole weight: 364.29. | |
| Ribavirin Impurity A | An impurity of Ribavirin. Ribavirin is an anti-viral medication used to treat RSV infection, hepatitis C, and viral hemorrhagic fever. Synonyms: Ribavirin carboxylic acid; 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid; USP Ribavirin Impurity A; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxylic acid. Grades: ≥95%. CAS No. 39925-19-4. Molecular formula: C8H11N3O6. Mole weight: 245.19. | |
| Riboflavin, 2',3',4',5'-tetraacetate | An impurity of Riboflavin. Riboflavin is a vitamin found in food and used as a dietary supplement. As a supplement it is used to prevent and treat riboflavin deficiency and prevent migraines. Synonyms: Riboflavin tetraacetate. CAS No. 752-13-6. Molecular formula: C25H28N4O10. Mole weight: 544.5. | |
| Riboflavin EP Impurity D | An impurity of Riboflavin, a vitamin found in food and used as a dietary supplement. As a supplement it is used to prevent and treat riboflavin deficiency and migraines. Synonyms: 8-Hydroxymethylriboflavin; 8alpha-Hydroxyriboflavin; 8-Hydroxymethyl Riboflavin; 8-(Hydroxymethyl)-7-methyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione. CAS No. 52134-62-0. Molecular formula: C17H20N4O7. Mole weight: 392.4. | |
| R-Ibuprofen | R-Ibuprofen is an inhibitor of Cox-1 and Cox-2 used as a nonsteroidal anti-inflammatory drug. Synonyms: l-Ibuprofen; Levibuprofen; (R)-(-)-Ibuprofen; (R)-Ibuprofen. Grades: > 95%. CAS No. 51146-57-7. Molecular formula: C13H18O2. Mole weight: 206.28. | |
| Rifabutin EP Impurity D | A derivative of Rifabutin.Rifabutin is an antibiotic used to treat tuberculosis and prevent and treat Mycobacterium avium complex. Synonyms: 3-Amino-1,4-dideoxy-1,4-dihydro-4-imino-1-oxorifamycin; 3-Amino-4-iminorifamycin S; 2, 7-(Epoxypentadeca[1, 11, 13]trienimino)naphtho[2, 1-b]furan, Rifamycin Deriv.; 3-Amino-4-deoxo-4-iminorifamycin S; 3-Amino-4-deoxy-4-iminorifamycin S; 3-Amino-1,4-dideoxy-1,4-dihydro-4-imino-1-oxorifamycin. Grades: 90%. CAS No. 62041-01-4. Molecular formula: C37H47N3O11. Mole weight: 709.8. | |
| Rifampicin N-Oxide | A metabolite of Rifampicin. Rifampicin is an antibiotic used to treat several types of bacterial infections. This includes tuberculosis, leprosy, and Legionnaire's. Synonyms: 3-[[(4-Methyl-4-oxido-1-piperazinyl)imino]methyl]rifamycin; 3-[[(4-methyl-1-piperazinyl)imino]methyl]rifamycin N-4'-Oxide. Grades: > 95%. CAS No. 125833-03-6. Molecular formula: C43H58N4O13. Mole weight: 838.96. | |
| Rifamycin O | Cas No. 14487-05-9. | |
| Rifamycin S | Cas No. 13553-79-2. | |
| Rifaximin | Rifaximin is a semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. It also acts as a pregnane X receptor (PXR) agonist. It is approved for the treatment of traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy. It is used to prevent and treat milk cow mastitis in the dry period caused by sensitive bacteria such as Staphylococcus aureus, Streptococcus and E. coli. Synonyms: 4-Deoxy-4'-methylpyridol[1',2'-1,2]imidazo[5,4-c]rifamycin SV; Rifamycin L 105; Rifaxidin; L-105; Fatroximin; Normix; Rifacol; Xifaxan. Grades: >98%. CAS No. 80621-81-4. Molecular formula: C43H51N3O11. Mole weight: 785.88. | |
| Rifaximin EP Impurity H | Rifaximin EP Impurity H is an intermediate of Rifaximin. Rifaximin is a semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. It also acts as a pregnane X receptor (PXR) agonist. It is approved for the treatment of traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy. Synonyms: 16-Desmethyl-16-(hydroxymethyl)rifaximin; (2S, 16Z, 18E, 20S, 21S, 22R, 23R, 24R, 25S, 26R, 27S, 28E)-25-(Acetyloxy)-5, 6, 21, 23-tetrahydroxy-16-(hydroxymethyl)-27-methoxy-2, 4, 11, 20, 22, 24, 26-heptamethyl-2, 7-(epoxypentadeca(1, 11, 13)trienimino)benzofuro(4, 5-E)pyrido(1, 2-a)benzimidazole-1, 15(2H)-dione. Grades: 90%. CAS No. 1210022-90-4. Molecular formula: C43H51N3O12. Mole weight: 801.88. | |
| Rigosertib sodium | Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Synonyms: Glycine, N-[2-methoxy-5-[[[ (1E) -2- (2, 4, 6-trimethoxyphenyl) ethenyl]sulfonyl]methyl]phenyl]-, monosodium salt (9CI); (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt; Novonex; ON 01910 sodium; ON01910 sodium; ON-01910 sodium; ON 01910 sodium salt; Rigosertib sodium. CAS No. 1225497-78-8. Molecular formula: C21H24NNaO8S. Mole weight: 473.47. | |
| Rilpivirine | A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent. Synonyms: R 278474; TMC 278; R-278474; R278474; TMC278; TMC-278. Grades: 0.98. CAS No. 500287-72-9. Molecular formula: C22H18N6. Mole weight: 366.428. | |
| Rilpivirine HCl | Rilpivirine, also known as TMC278, is a drug used as a part of antiretroviral therapy (ART). Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs. Uses: Anti-hiv agents. Synonyms: (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile hydrochloride; Rilpivirine hydrochloride; TMC278; TMC-278; TMC 278; Edurant. CAS No. 700361-47-3. Molecular formula: C22H19ClN6. Mole weight: 402.88. | |
| Rimonabant | Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Synonyms: SR141716; SR 141716; SR-141716. Grades: >98%. CAS No. 168273-06-1. Molecular formula: C22H21Cl3N4O. Mole weight: 463.79. | |
| Rimonabant Hydrochloride | Rimonabant Hydrochloride, used as a tool to investigate CB receptor properties, it is a selective antagonist of cannabinoid CB1 receptor (Ki = 1.98 nM) and inverses adenylyl cyclase inhibition (IC50 = 48 nM). Uses: A brain cannabinoid receptor (cb1) antagonist. antiobesity agent. Synonyms: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide; Rimonabant free base, SR141716; SR 141716; SR-141716; A 281; A-281; A281; Rimonabant, Acomplia, Zimulti. Grades: 98%. CAS No. 158681-13-1. Molecular formula: C22H21Cl3N4O.HCl. Mole weight: 500.25. | |
| Rineterkib | Rineterkib is a RAF and ERK1/2 inhibitor developed for the treatment of proliferative diseases characterized by activating mutations in the MAPK pathway. Synonyms: ERK-IN-1; LTT-462. CAS No. 1715025-32-3. Molecular formula: C26H27BrF3N5O2. Mole weight: 578.4. | |
| Ripretinib | Ripretinib is an orally bioavailable KIT/PDGFR inhibitor with antitumor effect. It binds to both wild-type and mutant forms of KIT and PDGFRa at their switch pocket binding site. Synonyms: DCC-2618; 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea. CAS No. 1442472-39-0. Molecular formula: C24H21BrFN5O2. Mole weight: 510.36. | |
| Risdiplam | Risdiplam is an orally available SMN2 pre-mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). Synonyms: RG7916; RG-7916; RG 7916; RO7034067. CAS No. 1825352-65-5. Molecular formula: C22H23N7O. Mole weight: 401.5. | |
| Risedronate acid | Risedronate is a bisphosphonate and a calcium channel blocker that is used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. Synonyms: Risedronate; (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid. Grades: > 98%. CAS No. 105462-24-6. Molecular formula: C7H11NO7P2. Mole weight: 283.113. | |
| Rivaroxaban Aminomethyl Hydrochloride Impurity | Cas No. 898543-06-1. | |
| Rivaroxaban Dichloro Impurity | An impurity of Rivaroxaban. Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. Synonyms: 2-Thiophenecarboxamide, 4,5-dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-; (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide. Grades: 95%. CAS No. 1770812-37-7. Molecular formula: C19H17Cl2N3O5S. Mole weight: 470.33. | |
| Rivaroxaban Open-Ring N-Methyl Impurity | An impurity of Rivaroxaban. Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. Synonyms: 4'-Desmorpholino 4'-[N-(5-chloro-2-carboxy-thienyl)N-(5-Carboxy-3-oxa-pentyl)]amino Rivaroxaban; (S)-5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-(methylamino)-2-oxoethoxy)ethyl)thiophene-2-carboxamide. CAS No. 1807455-76-0. Molecular formula: C25H24Cl2N4O6S2. Mole weight: 611.52. | |
| Rivaroxaban Urea Dimer Impurity | An impurity of Rivaroxaban. Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. Synonyms: N,N'-Bis[Des(5-chloro-2-carvoxythienyl) Rivaroxaban] Urea; N,N'-Bis[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]urea; Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-. CAS No. 1365267-35-1. Molecular formula: C29H32N6O9. Mole weight: 608.60. | |
| Rivastigmine Impurity F | An impurity of Rivastigmine. Rivastigmine is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Synonyms: (αS)-3-Methoxy-N,N,α-trimethylbenzenemethanamine; (S)-1-(3-Methoxyphenyl)-N,N-dimethylethanamine; Rivastigmine EP Impurity F. Grades: ≥95%. CAS No. 889443-69-0. Molecular formula: C11H17NO. Mole weight: 179.26. | |
| Rivastigmine USP Related Compound F | An impurity of Rivastigmine, a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce symptoms of dementia in patients with Alzheimer disease. Synonyms: 3-Vinylphenyl ethyl(methyl)carbamate; 3-Ethenylphenyl ethyl(methyl)carbamate; N-Ethyl-N-methyl-3-vinylphenyl Carbamate. Grades: > 95%. CAS No. 1346602-84-3. Molecular formula: C12H15NO2. Mole weight: 205.26. | |
| Rizatriptan Impurity C | An impruity of Rizatriptan. Rizatriptan is a serotonin 5-HT1 receptor agonist. It works by narrowing dilated blood vessels in the brain, relieving migraine headaches. Grades: > 95%. CAS No. 208941-96-2. Molecular formula: C15H19N5. Mole weight: 269.35. | |
| (R)-(-)-JQ1 | (R)-(-)-JQ1 is the R-isomer and an inactive control of JQ1, a BET bromodomain inhibitor. Synonyms: (-)-JQ1; (-)-JQ 1; (-)-JQ-1; (R)-JQ1; (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate. Grades: >95%. CAS No. 1268524-71-5. Molecular formula: C23H25ClN4O2S. Mole weight: 456.989. | |
| RKI-1313 | RKI-1313 is a negative control of RKI-1447, which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activity. Synonyms: RKI-1313; RKI 1313; RKI1313. 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. CAS No. 1342276-76-9. Molecular formula: C17H16N4O2S. Mole weight: 340.401. | |
| RMC-4550 | RMC-4550 is a potent and selective SHP-2 inhibitor with IC50 value of 1.55 nM. It inhibits RAS/MAPK signaling in cancer cell lines with Class 3 BRAF mutations. Synonyms: RMC 4550; RMC4550. CAS No. 2172651-73-7. Molecular formula: C21H26Cl2N4O2. Mole weight: 437.36. | |
| (R)-Mevalonolactone | (R)-Mevalonolactone is a key intermediate used in the preparation of vitamin E. Synonyms: (-)-Mevalonolactone; (4R)-Tetrahydro-4-hydroxy-4-methyl-2H-Pyran-2-one; (-)-(R)-Mevalonic Acid Lactone; (-)-(R)-Mevalonolactone. Grades: ≥90%. CAS No. 19115-49-2. Molecular formula: C6H10O3. Mole weight: 130.14. | |
| (R)-N-(1-(3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)formamide | An impurity of Trelagliptin. Trelagliptin is a pharmaceutical drug used for the treatment of type 2 diabetes. Synonyms: Trelagliptin Impurity 16. Grades: 99%. CAS No. 2087874-91-5. Molecular formula: C19H20FN5O3. Mole weight: 385.39. | |
| (R)-N-(1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)benzamide | (R)-N-(1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)benzamide is an impurity of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in the class of oral antidiabetic drugs. Synonyms: Alogliptin Impurity 12; 1618644-32-8; (R)-N-(1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6- tetrahydropyrimidin-4-yl)piperidin-3-yl)benzamide. CAS No. 1618644-32-8. Molecular formula: C25H25N5O3. Mole weight: 443.5. | |
| (R)-N-Desacryloyl N-3-Propionyl Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one. Grades: ≥95%. CAS No. 1288338-96-4. Molecular formula: C25H25ClN6O2. Mole weight: 476.96. | |
| (R)-N-Desacryloyl N-Propionyl Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Propanone, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-. Grades: ≥95%. CAS No. 1839099-22-7. Molecular formula: C25H26N6O2. Mole weight: 442.51. | |
| (R)-(-)-Nirvanol | (R)-(-)-Nirvanol is a Mephentoin metabolite with anticonvulsant and hypnotic properties. Synonyms: (R)-5-Ethyl-5-phenylimidazolidine-2,4-dione; R-(-)-N-Desmethyl Mephenytoin; (-)-5-Ethyl-5-phenylhydantoin. Grades: 95%. CAS No. 65567-32-0. Molecular formula: C11H12N2O2. Mole weight: 204.23. | |
| (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine | (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine is an impurity of Duloxetine, an antidepressant medication used to treat major depressive disorder. Synonyms: (s)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine. CAS No. 878757-08-5. Molecular formula: C19H21NSO. Mole weight: 311.44. | |
| (R)-N-((S)-1-amino-1-oxobutan-2-yl)-3-(bromomethyl)hexanamide | Cas No. 2242647-55-6. | |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. Synonyms: RO0335; RO 0335; N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoroBenzeneacetamide. Grades: 99%. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.21. | |
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