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RO1138452
RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine. CAS No. 221529-58-4. Molecular formula: C19H23N3O. Mole weight: 309.413.
RO-5028442
RO-5028442 is a potent and brain-penetrant hV1a antagonist. RO-5028442 is undergoing clinical trials for autistic disorder therapy. Synonyms: RO-5028442; RO 5028442; RO5028442. [6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone. CAS No. 920022-47-5. Molecular formula: C25H28ClN3O2. Mole weight: 437.968.
Rociletinib is a third-generation irreversible kinase inhibitor of epidermal growth factor receptor (EGFR). Rociletinib was shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR. It also exhibits anti-tumor activity in NSCLC EGFR mutant xenograft models. Synonyms: CO-1686; CO1686; CO 1686; AVL-301; AVL 301; AVL301; CNX-419; CNX 419; CNX419; N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. CAS No. 1374640-70-6. Molecular formula: C27H28F3N7O3. Mole weight: 555.562.
Rocuronium bromide
Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant. Synonyms: ORG 9426; ORG-9426; ORG9426. Grades: >98%. CAS No. 119302-91-9. Molecular formula: C32H53N2O4.Br. Mole weight: 609.68.
Rocuronium bromide EP impurity F
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 2-Pyrrolidinyl-3-acetyl Desmorpholinylrocuronium Bromide; 1-[(2β, 3α, 5α, 16β, 17β)-3, 17-Bis(acetyloxy)-2-(1-pyrrolidinyl)androstan-16-yl]-1-(2-propen-1-yl)-pyrrolidinium. Grades: > 95%. CAS No. 1190105-66-8. Molecular formula: C34H55N2O4.Br. Mole weight: 635.72.
Rocuronium EP Impurity A
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 2β-(4-Morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstane-3α,17β-diol 17-Acetate; (2β, 3α, 5α, 16β, 17β)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3, 17-diol 17-Acetate; Desallyl Rocuronium. Grades: 99 %. CAS No. 119302-24-8. Molecular formula: C29H48N2O4. Mole weight: 488.72.
Rocuronium EP Impurity C
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 17-Desacetyl Rocuronium Bromide; 1-[(2β, 3α, 5α, 16β, 17β)-3, 17-Dihydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide. Grades: > 95%. CAS No. 119302-86-2. Molecular formula: C30H51N2O3.Br. Mole weight: 567.65.
Rocuronium EP Impurity E
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 2-Pyrrolidinyl Desmorpholinylrocuronium Bromide; 1-[(2β, 3α, 5α, 16β, 17β)-17-(Acetyloxy)-3-hydroxy-2-(1-pyrrolidinyl)androstan-16-yl]-1-(2-propen-1-yl)-pyrrolidinium Bromide. Grades: > 95%. CAS No. 1190105-65-7. Molecular formula: C32H53N2O3. Br. Mole weight: 593.69.
Rocuronium EP Impurity G
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 2β-(4-Morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstane-3α,17β-diol; (2β, 3α, 5α, 16β, 17β)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstan-3, 17-diol; Desacetyl Desallyl Rocuronium. Grades: 99 %. CAS No. 119302-20-4. Molecular formula: C27H46N2O3. Mole weight: 446.68.
Rocuronium EP Impurity H
An impurity of Rocuronium. Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. Synonyms: 1,2-Dehydro-3-oxo Rocuronium Bromide; Rocuronium Bromide Impurity 21; 1-[(5α,16β,17β)-17-(Acetyloxy)-2-(4-morpholinyl)-3-oxoandrost-1-en-16-yl]-1-(2-propen-1-yl)-pyrrolidinium Bromide. Grades: > 95%. CAS No. 1190105-67-9. Molecular formula: C32H49N2O4.Br. Mole weight: 605.65.
Rofecoxib
Rofecoxib is a COX-2 inhibitor (IC50s = 26 nM and > 50 μM in human osteosarcoma cells). Uses: Cyclooxygenase 2 inhibitors. Synonyms: MK966; MK966; MK 966; MK0966; MK0966; MK 0966; Rofecoxib; brand name: Vioxx; Ceoxx; Ceeoxx. 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone. Grades: > 95%. CAS No. 162011-90-7. Molecular formula: C17H14O4S. Mole weight: 314.4.
Rolapitant
Rolapitant is a selective NK1 receptor antagonist (antagonist for the NK1 receptor). Synonyms: (5S, 8S) -8- ( ( (R) -1- (3, 5-bis (trifluoromethyl) phenyl) ethoxy) methyl) -8-phenyl-1, 7-diazaspiro[45]decan-2-one; SCH619734; SCH-619734; SCH 619734; Varubi. Grades: >95%. CAS No. 552292-08-7. Molecular formula: C25H26F6N2O2. Mole weight: 500.49.
Romifidine hydrochloride
Romifidine is an α2 agonist used as a sedative and analgesic in horses. Synonyms: N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride; STH 2130Cl; Sedivet. CAS No. 65896-14-2. Molecular formula: C9H10BrClFN3. Mole weight: 294.55.
Rostafuroxin
Rostafuroxin is a Na+/K+ ATPase modulator that treats hypertension by normalizing renal Na+/K+ ATPase pump function. Synonyms: PST-2238; PST 2238; (3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol. Grades: 98.07%. CAS No. 156722-18-8. Molecular formula: C23H34O4. Mole weight: 374.521.
Rosuvastatin (6S)-Lactone Impurity
An impurity of Rosuvastatin. Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Synonyms: N-[(6S)-8-Fluoro-5,6-dihydro-4-(1-methylethyl)-6-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]benzo[h]quinazolin-2-yl]-N-methylmethane sulfonamide; N-((S)-8-fluoro-6-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)-4-isopropyl-5,6-dihydrobenzo[h]quinazolin-2-yl)-N-methylmethanesulfonamide. CAS No. 854898-47-8. Molecular formula: C22H26FN3O5S. Mole weight: 463.52.
Rotigotine Hydrochloride
The hydrochloride salt form of Rotigotine which is a dopamine D2 and D3 receptor agonist and has been shown to be effective in the treatment of Parkinson's disease. IC50: 13 nM and 0.71 nM for D2 and D3 receptor respectively. Uses: The hydrochloride salt form of rotigotine which is a dopamine d2 and d3 receptor agonist and has been shown to be effective in the treatment of parkinson's disease. Synonyms: Rotigotine hydrochloride; Rotigotine HCl; Rotigotine (Hydrochloride); (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride; (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride. Grades: >99 %. CAS No. 125572-93-2. Molecular formula: C19H26ClNOS. Mole weight: 351.93.
Roxatidine hydrochloride
An impurity of potent Rotundine. Rotundine is a selective dopamine D1 receptor antagonist. Synonyms: Acetamide, 2-hydroxy-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-, monohydrochloride. CAS No. 97900-88-4. Molecular formula: C17H27ClN2O3. Mole weight: 342.86.
(R)-Oxybutynin Chloride
(R)-Oxybutynin Chloride is an impurity of Oxybutynin, which is a medication used to treat overactive bladder. Synonyms: (R)-α-Phenylcyclohexaneglycolic Acid 4-(Diethylamino)-2-butynyl Ester, Hydrochloride. Grades: 98%. CAS No. 1207344-05-5. Molecular formula: C22H32ClNO3. Mole weight: 393.95.
(R)-Ranolazine
(R)-Ranolazine is the R-isomer of Ranolazine, which is a medication used to treat heart-related chest pain. Synonyms: 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[(2R)-2-hydroxy-3-(2-methoxyphenoxy)propyl]-; (R)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide; (+)-Ranolazine. Grades: ≥95%. CAS No. 114246-80-9. Molecular formula: C24H33N3O4. Mole weight: 427.54.
(R,R)-Hydroxy Bupropion
(R,R)-Hydroxy Bupropion is the (R,R) Enantiomer metabolite of Bupropion, an antidepressant. Synonyms: (2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; (2R-cis)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; (-)-(2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol; Bupropion Morpholinol (2R,3R)-Isomer. Grades: > 95%. CAS No. 192374-15-5. Molecular formula: C13H18ClNO2. Mole weight: 255.75.
(R,R)-Isophytol
(R,R)-Isophytol is an impurity of Vitamin K1, which is a fat-soluble vitamin commonly used in dietary supplement for the treatment of bleeding disorders. Synonyms: Vitamin K1 Impurity 22; 3-Amboisophytol; (2RS,7R,11R)-Isophytol; (7R,11R)-3,7,11,15-Tetramethyl-1-hexadecen-3-ol. Grades: ≥95%. CAS No. 395645-30-4. Molecular formula: C20H40O. Mole weight: 296.53.
(R,R)-Montelukast Bis-sulfide
Cas No. 1187586-61-3.
(R)-(+)-Ropivacaine hydrochloride
(R)-(+)-Ropivacaine hydrochloride is an isomer of Ropivacaine, a local anaesthetic drug belonging to the amino amide group. Synonyms: (R)-Ropivacaine Hydrochloride; Ropivacaine hydrochloride, (R)-; USP Ropivacaine Related Compound B; Ropivacaine EP Impurity G. Grades: 95%. CAS No. 112773-90-7. Molecular formula: C17H27ClN2O. Mole weight: 310.86.
(R,R)-Palonosetron HCl
An impurity of Palonosetron which is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting. Synonyms: Palonosetron (R,R)-Isomer (HCl Salt); (3aR)-2-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one HCl. Grades: > 95%. CAS No. 135729-75-8. Molecular formula: C19H24N2O.HCl. Mole weight: 332.86.
[R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid
[R-(R*,R*)]-(1,2-Dihydroxypropyl)phosphonic Acid is one of fosfomycin impurities. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. It was produced by certain Streptomyces species. Synonyms: Fosfomycin EP Impurity A. Grades: 96%. CAS No. 132125-60-1. Molecular formula: C3H9O5P. Mole weight: 156.07.
(R,S)-4-Hydroxy Cyclophosphamide
(R,S)-4-Hydroxy Cyclophosphamide is a metabolite of Cyclophosphamide. Synonyms: (2R,4S)-rel-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-Oxide. Grades: > 95%. CAS No. 61903-30-8. Molecular formula: C7H15Cl2N2O3P. Mole weight: 277.09.
(R,S)-Ethambutol
An isomer of Ethambutol. Ethambutol is a medication primarily used to treat tuberculosis. Synonyms: (R,S)-Ethambutol; meso-N, N'-Bis[1- (hydroxymethyl) propyl]ethylenediamine; USP Ethambutol Related Compound A. Grades: > 95%. CAS No. 10054-06-5. Molecular formula: C10H24N2O2. Mole weight: 204.31.
(R,S)-Montelukast Bis-sulfide
Cas No. 1187586-58-8.
(R,S)-Norcotinine
(R,S)-Norcotinine is a metabolite of (+/-)-Cotinine. Synonyms: 5-(3-Pyridinyl)-2-pyrrolidinone; (+/-)-Demethylcotinine; (+/-)-Norcotinine. Grades: > 95%. CAS No. 17708-87-1. Molecular formula: C9H10N2O. Mole weight: 162.19.
(R,S)-Norcotinine N-Oxide
(R,S)-Norcotinine N-Oxide is a metabolite of Nicotine in human blood plasma. Synonyms: 5-(1-Oxido-3-pyridinyl)-2-pyrrolidinone; (+/-)-5-(3-Pyridinyl)-2-pyrrolidinone N-Oxide. Grades: > 95%. CAS No. 101708-63-8. Molecular formula: C9H10N2O2. Mole weight: 178.19.
(R,S)-Palonosetron HCl
An impurity of Palonosetron which is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Uses: Antiemetics. Synonyms: Palonosetron (R,S)-Isomer (HCl Salt); (3aR)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one HCl. Grades: > 95%. CAS No. 135755-51-0. Molecular formula: C19H24N2O.HCl. Mole weight: 332.86.
One impurity of Terazosin, which is a piperazine derivative and has been found to be an α-1-adrenergic blocker. Synonyms: (R)-Terazosin; 109351-34-0; [4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)piperazin-1-Yl][(2r)-Tetrahydrofuran-2-Yl]methanone[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-[(2R)-oxolan-2-yl]methanone; (R)-(4-(4-AMINO-6,7-DIMETHOXYQUINAZOLIN-2-YL)PIPERAZIN-1-YL)(TETRAHYDROFURAN-2-YL)METHANONE. Grades: 95%. CAS No. 109351-34-0. Molecular formula: C19H25N5O4. Mole weight: 387.43.
(R)-tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
(R)-tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: (5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester; R-tert-Butyl 6-Cyano-5-hydroxy-3-oxohexanoate. CAS No. 125988-01-4. Molecular formula: C11H17NO4. Mole weight: 227.26.
(R)-Tetrahydrofuran-2-carbothioic S-acid
An impurity of Faropenem. Faropenem is an oral penem, closely related to the carbapenem class that is used for the treatment of bacterial infections. Synonyms: (2R)?-tetrahydro-2-Furancarbothioic acid. Grades: > 95%. CAS No. 153165-72-1. Molecular formula: C5H8O2S. Mole weight: 132.18.
(R)-Timolol Maleate
The R-enantiomer of Timolol Maleate which is an adrenergic beta-receptor blocking agent and a Class II antiarrhythmic drug. Synonyms: Timolol Impurity A Maleate. Grades: > 95%. CAS No. 26839-77-0. Molecular formula: C13H24N4O3S.C4H4O4. Mole weight: 432.5.
(R)-trans-Atracurium Besylate
(R)-trans-Atracurium Besylate is an impurity of Cisatracurium, an enantiomer of a neuromuscular blocking agent. Synonyms: (1R,2S,1'R,2'S)-2,2'-{1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate. CAS No. 96946-46-2. Molecular formula: C65H82N2O18S2. Mole weight: 1243.48.
(R)-Trolox
(R)-Trolox is used in the synthesis of vitamin E analogs. Synonyms: (2R)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic Acid; (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic Acid; (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid. Grades: 98%. CAS No. 53101-49-8. Molecular formula: C14H18O4. Mole weight: 250.29.
RU 58841
RU 58841 is a new non-steroidal antiandrogen which has potential for use in treating androgen-dependent skin disorders such as acne, hirsutism and androgen-dependent alopecia. Synonyms: RU-58841; RU58841; RU 58841; 4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxybutyl)-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile. CAS No. 154992-24-2. Molecular formula: C17H18F3N3O3. Mole weight: 369.34.
RU-59063
RU-59063 is a nonsteroidal androgen or selective androgen receptor modulator (SARM). Synonyms: RU 59063; 4-(3-(4-Hydroxybutyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile. CAS No. 155180-53-3. Molecular formula: C17H18F3N3O2S. Mole weight: 385.4.
Rubitecan
Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. This agent also prevents repair of reversible single-strand DNA breaks. Synonyms: RFS 2000; 9-Nitrocamptothecin; (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizinol[1,2-b]quinoline-3,14(4H,12H)-dione; 9-NC; Orathecin; 9-nitro-20(S)-camptothecin; Camptogen; (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 9-nitro-CPT; Nitrocamptothecin. Grades: ≥98%. CAS No. 91421-42-0. Molecular formula: C20H15N3O6. Mole weight: 393.35.
Ruboxistaurin HCl
Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Uses: Enzyme inhibitors. Synonyms: Ruboxistaurin Hydrochloride; LY-333531 hydrochloride; Ruboxistaurin (hydrochloride); 169939-93-9; LY 333531 hydrochloride; LY333531 hydrochloride; Ruboxistaurin-d6 Hydrochloride; 169939-94-0 (base). Grades: > 95%. CAS No. 169939-93-9. Molecular formula: C28H28N4O3.HCl. Mole weight: 505.01.
Ruxolitinib phosphate
Ruxolitinib phosphate is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate. Grades: >98%. CAS No. 1092939-17-7. Molecular formula: C17H21N6O4P. Mole weight: 404.36.
(R)-(-)-VAPOL hydrogenphosphate
(R)-(-)-VAPOL hydrogenphosphate is a chiral phosphoric acid catalyst for a variety of enantioselective transformations, especially for carbon-carbon and carbon-heteroatom bond-forming reactions. Synonyms: (S)-VAPOL hydrogenphosphate; (8aR)-18-Hydroxy-8,9-diphenyldiphenanthro[4,3-d:3',4'-f][1,3,2]dioxaphosphepine 18-oxide. Grades: 95%. CAS No. 871130-18-6. Molecular formula: C40H25O4P. Mole weight: 600.60.
(R)-Viloxazine Hydrochloride
The R-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant. Uses: The (r)-isomer of. Synonyms: Morpholine, 2-[(2-ethoxyphenoxy)methyl]-, hydrochloride, (R)-. CAS No. 56287-63-9. Molecular formula: C13H20ClNO3. Mole weight: 273.76.
(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-2H-[1,4]oxazino[2,3,4-ij]quinolin-7(3H)-one hydrochloride is an impurity of Pazufloxacin. Pazufloxacin is a fluoroquinolone antibiotic. Synonyms: Pazufloxacin Impurity 07. CAS No. 143457-45-8. Molecular formula: C15H16ClFN2O2. Mole weight: 310.75.
(S)-10-(1-aminocyclopropyl)-9-fluoro-6-hydroxy-3-methyl-2H-[1,4]oxazino[2,3,4-ij]quinolin-7(3H)-one hydrochloride is an impurity of Pazufloxacin. Pazufloxacin is a fluoroquinolone antibiotic. Synonyms: Pazufloxacin Impurity 06. CAS No. 171567-51-4. Molecular formula: C15H16ClFN2O3. Mole weight: 326.75.
S107
S107 is a type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. S107 increased FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. Synonyms: 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride; S107; S-107; S 107. CAS No. 927871-76-9. Molecular formula: C11H15NOS. Mole weight: 209.31.
(S)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt
(S)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt is a metabolite of Carbamazepine, which is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. Synonyms: (10S)-5-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; (S)-5-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; Eslicarbazepine Glucuronide Sodium Salt; Sodium (2S,3S,4S,5R,6R)-6-[[(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylate. Molecular formula: C21H21N2NaO8. Mole weight: 452.39.
S-((1-(2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl)cyclopropyl)methyl) Ethanethioate is an intermediate of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Synonyms: Ethanethioic acid, S-[[1-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)cyclopropyl]methyl] ester. Molecular formula: C11H16O4S. Mole weight: 244.31.
(S)-1,2,3,4-Tetrahydro-1-naphthalenemethanol
(S)-1,2,3,4-Tetrahydro-1-naphthalenemethanol is an intermediate in the synthesis of Palonosetron, which is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Synonyms: (S)-1,2,3,4-Tetrahydronaphthalene-1-methanol; (S)-(1,2,3,4-Tetrahydronaphthalen-1-yl)methanol; 1-Naphthalenemethanol, 1,2,3,4-tetrahydro-, (1S)-; Palonosetron Impurity 52. Grades: ≥95%. CAS No. 151831-52-6. Molecular formula: C11H14O. Mole weight: 162.23.
(S)-1-Methylnicotinium Iodide
(S)-1-Methylnicotinium Iodide is one of Nicotine metabolites, which is a potent parasympathomimetic stimulant. Uses: A metabolite of nicotine. Synonyms: (S)-1-Methyl-3-(1-methyl-2-pyrrolidinyl)pyridinium Iodide; NIM; 1-Methyl-nicotinium Iodide; 1-Methyl-3-[(2S)-1-methyl-2-pyrrolidinyl]-pyridinium Iodide; 1-Methyl-3-(1-methyl-2-pyrrolidinyl)pyridinium Iodide; N-Methylnicotinium Iodide; Nicotine N-Methiodide; Nicotine Isomethiodide. Grades: 95%. CAS No. 21446-46-8. Molecular formula: C11H17IN2. Mole weight: 304.17.
(S)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione is an impurity of Apremilast, which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. CAS No. 2077897-93-7. Molecular formula: C20H21NO6S. Mole weight: 403.45.
(S)-2-((3-(4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: Linezolid Impurity 31. CAS No. 556801-12-8. Molecular formula: C22H21N3O5. Mole weight: 407.42.
(S) -2-acetamido-6- ( (1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl) carbamoyl) benzoic acid is an impurity of Apremilast, which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Synonyms: 2-Acetamido-6-{[ (1S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl]carbamoyl}benzoic acid. CAS No. 1809170-71-5. Molecular formula: C22H26N2O8S. Mole weight: 478.52.
(S)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: Linezolid Impurity 28. CAS No. 2180621-71-8. Molecular formula: C15H19FN2O6S. Mole weight: 374.38.
(S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: 2-Oxazolidinone, 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-, (5S); Linezolid Impurity 24. CAS No. 2180529-06-8. Molecular formula: C14H17FN2O4. Mole weight: 296.29.
(S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (3S) -3-[4-[ (5-Bromo-2-chlorophenyl) methyl]phenoxy]tetrahydrofuran; Empagliflozin Impurity I. CAS No. 915095-89-5. Molecular formula: C17H16BrClO2. Mole weight: 367.66.
(S)-3-(4-Chlorophenyl)-4-hydroxybutyric Acid Sodium Salt
(S)-3-(4-Chlorophenyl)-4-hydroxybutyric Acid Sodium Salt is a metabolite of Baclofen, which is a specific GABA-B receptor agonist with muscle relaxant effect. Synonyms: (S)-β-(p-Chlorophenyl)-γ-hydroxybutyric Acid Sodium Salt; (S)-4-Chloro-β-(hydroxymethyl)benzenepropanoic Acid Sodium Salt. Grades: 98%. CAS No. 1346617-13-7. Molecular formula: C10H10ClNaO3. Mole weight: 236.63.
An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity SYGIM. Grades: ≥95%. CAS No. 1642630-12-3. Molecular formula: C22H22N6O. Mole weight: 386.45.
(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol
(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol is an intermediate of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: Aprepitant intermediate. Synonyms: (αS)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol; (S)-3,5-Bis(trifluoromethyl) Phenethyl Alcohol; (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol; (1S)-(-)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol; Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αS)-. Grades: ≥95%. CAS No. 225920-05-8. Molecular formula: C10H8F6O. Mole weight: 258.16.
S38093 HCl
S38093 HCl is a histamine H3 antagonist/inverse agonist. Synonyms: S38093 Hydrochloride; S 38093 Hydrochloride; S-38093 Hydrochloride; S-38093 HCl; S 38093 HCl; S38093 HCl; BCP29143; BCP 29143; BCP-29143; 4-[3-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)propoxy]benzamide hydrochloride. CAS No. 1222097-72-4. Molecular formula: C17H25ClN2O2. Mole weight: 324.849.
(S) -3-acetamido-2- ( (1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl) carbamoyl) benzoic acid is an impurity of Apremilast, which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Synonyms: 3-Acetamido-2-{[ (1S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl]carbamoyl}benzoic acid. CAS No. 2096492-41-8. Molecular formula: C22H26N2O8S. Mole weight: 478.52.
An impurity of Rivaroxaban. Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. Synonyms: 2-Thiophenecarboxamide, 3-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-; Rivaroxaban Impurity 21. CAS No. 1855920-54-5. Molecular formula: C19H18ClN3O5S. Mole weight: 435.88.
(S)-3-(dimethylamino)-1-(thiophen-3-yl)propan-1-ol is an impurity of Duloxetine, an antidepressant medication used to treat major depressive disorder. Synonyms: rac-alpha-[2-(Dimethylamino)ethyl]-3-thiophenemethanol. CAS No. 1384080-56-1. Molecular formula: C9H15NOS. Mole weight: 185.29.