BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| HIV-IN-8 | HIV-IN-8 is a HIV inhibitor. Synonyms: (2R)-2-(3-{[(1R)-2-(3,4-Dihydroxyphenyl)-1-carboxyethyl]oxycarbonyl}(4S,3R)-4-(3,4-dihydroxyphenyl)-6,7-dihydroxy(2-3,4-dihydronaphthylcarbonyloxy))-3-(3,4-dihydroxyphenyl)propanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(1S,2R)-1-(3,4-dihydroxyphenyl)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-hydroxy-2-oxo-ethoxy]carbonyl-6,7-dihydroxy-1,2-dihydronaphthalene-2-carbonyl]oxy-propanoic acid. CAS No. 130286-75-8. Molecular formula: C36H30O16. Mole weight: 718.61. |  |
| HJC-0123 | HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grade: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46. | |
| HJC0197 | HJC0197 is an erythromycin propionate-N-acetylcysteinate inhibitor (EPAC) with IC50 value of 5.9 μM for Epac2. HJC0197 can inhibit Epac1-mediated Rap1-GDP exchange activity at 25 μM, but it has no effect on cAMP-induced type I and II PKA activity at this concentration. HJC0197 can be used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion. Uses: Study the role of epac signaling. Synonyms: HJC-0197; HJC 0197; 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Grade: 98%. CAS No. 383539-73-8. Molecular formula: C19H21N3OS. Mole weight: 339.45. | |
| HJC0350 | HJC0350 is a potent and Epac2-specific inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Synonyms: HJC 0350; HJC-0350; 1-(mesitylsulfonyl)-2,4-dimethyl-1H-pyrrole. Grade: >98%. CAS No. 885434-70-8. Molecular formula: C15H19NO2S. Mole weight: 277.38. | |
| HJC0416 hydrochloride | HJC0416 hydrochloride is a potent anticancer agent, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Synonyms: HJC0416 (hydrochloride). CAS No. 2415263-08-8. Molecular formula: C18H18Cl2N2O4S. Mole weight: 429.32. | |
| HKI 357 | HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grade: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. | |
| HL 010183 | HL 010183 is a metformin derivative exhibiting potent antitumor effect. It inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells. Uses: Antitumor agent. Synonyms: HL 010183; HL010183; HL-010183. Grade: 99%. CAS No. 1429218-03-0. Molecular formula: C14H20N6.HCl. Mole weight: 308.81. | |
| HLCL61 | HLCL61 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. It is used for treatment of acute myeloid leukemia. It resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in acute myeloid leukemia cells. Uses: Hlcl61 is used for treatment of acute myeloid leukemia. Synonyms: HLCL-61; HLCL 61; 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine. Grade: 98%. CAS No. 586395-74-6. Molecular formula: C23H24N2O. Mole weight: 344.19. | |
| HLCL-61 hydrochloride | The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia. Uses: The hydrochloride salt form of hlcl-61 is an effective inhibitor of prmt5 and could probably useful in the treatment of acute myeloid leukemia. Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride; HLCL61; HLCL 61; HLCL-61. Grade: 98%. CAS No. 1158279-20-9. Molecular formula: C23H25ClN2O. Mole weight: 380.91. | |
| HLCL65 hydrochloride | HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses recall T cell responses and reduces inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models; In vitro, HLCL65 effectively inhibits symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples. Synonyms: HLCL65 hydrochloride; HLCL 65 hydrochloride; HLCL-65 hydrochloride; 1-(6-bromo-9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine hydrochloride. Grade: 99%. Molecular formula: C23H23BrN2O.HCl. Mole weight: 459.81. | |
| HLI 373 | HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grade: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33. | |
| HLM006474 | HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grade: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| HLY78 | HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb. Synonyms: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine. Grade: ≥98%. CAS No. 854847-61-3. Molecular formula: C17H17NO2. Mole weight: 267.3. | |
| H-Lys-Trp-Lys-OH | H-Lys-Trp-Lys-OH is the positively charged oligopeptide. It displays antibacterial and antiviral activities. Synonyms: Lysyl-tryptophyl-alpha-lysine; N2-(N-L-Lysyl-L-tryptophyl)-L-lysine; L-Lys-L-Trp-L-Lys-OH. Grade: ≥98%. CAS No. 38579-27-0. Molecular formula: C23H36N6O4. Mole weight: 460.57. | |
| HM03 trihydrochloride | HM03 trihydrochloride is a potent and selective inhibitor of HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) with anticancer activity. Synonyms: 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]phenol trihydrochloride; Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-, hydrochloride (1:3). Grade: ≥95%. CAS No. 1082532-95-3. Molecular formula: C26H30Cl4N4O2. Mole weight: 572.35. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I trials. HM30181 was well tolerated after oral administration within the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed.trials. HM30181 was well tolerated after oral administration within the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-B | |
| HM-30181 hydrochloride | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 hydrochloride; HM 30181 hydrochloride; HM30181 hydrochloride; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide hydrochloride. Grade: 98%. CAS No. 849675-88-3. Molecular formula: C38H37ClN6O7. Mole weight: 725.20. | |
| HM-30181 mesylate | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 mesylate; HM 30181 mesylate; HM30181 mesylate; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate; 849675-88-3 (HM30181 HCl salt); 49675-66-7 (HM30181 Free base). Grade: 98%. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. | |
| HM-30181 mesylate monohydrate | HM-30181 mesylate monohydrate is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Synonyms: Encequidar mesylate monohydrate; HM-30181 methanesulfonate monohydrate; HM30181 mesylate monohydrate; 4H-1-Benzopyran-2-carboxamide, N-(2-(2-(4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-, methanesulfonate, hydrate (1:1:1); FM0F74; HM 30181A; N-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide methanesulfonate hydrate (1:1:1); N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide methanesulfonate hydrate (1:1:1); TCA.MSA. Grade: ≥95%. CAS No. 2097125-58-9. Molecular formula: C38H36N6O7.CH4O3S.H2O. Mole weight: 802.85. | |
| HM43239 | HM43239 is an orally active and selective inhibitor of FLT3. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. Synonyms: HM-43239; HM 43239. CAS No. 2569527-64-4. Molecular formula: C29H33ClN6. Mole weight: 501.07. | |
| HM 50316 | HM 50316 is a high affinity fatty-acid binding protein 4 (FABP4) inhibitor (Ki < 1 nM) that selectively inhibits FABP4 over FABP3. It inhibits LPS-induced activation of murine macrophages in vitro. HM 50316 may be beneficial for the treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. Synonyms: HM-50316; HM 50316; HM50316. 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid. Grade: ≥98% by HPLC. CAS No. 1310361-52-4. Molecular formula: C29H23ClN2O3S. Mole weight: 515.02. | |
| HMB-Val-Ser-Leu-VE | HMB-val-ser-leu-VE is a potent and selective inhibitor of the trypsin-like activity of the 20S proteasome. Synonyms: Ethyl (E,4S)-4-[[(2S)-3-hydroxy-2-[[(2S)-2-[(3-hydroxy-2-methylbenzoyl)amino]-3-methylbutanoyl]amino]propanoyl]amino]-6-methylhept-2-enoate. Grade: ≥98%. CAS No. 862891-04-1. Molecular formula: C26H39N3O7. Mole weight: 505.6. | |
| HMG499 | HMG499 is a potent and selective HMG-CoA reductase inhibitor. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis. CAS No. 2416941-68-7. Molecular formula: C33H54O3. Mole weight: 498.79. | |
| HMG-CoA | HMG-CoA is an intermediate in the mevalonate pathway. Synonyms: S-(Hydrogen 3-Hydroxy-3-methylglutarate) Coenzyme A; 3-Hydroxy-3-methylglutaryl CoA; 3-Hydroxy-3-methylglutaryl Coenzyme A; Hydroxymethylglutaryl CoA; Hydroxymethylglutaryl Coenzyme A; β-Hydroxy-β-methylglutaryl CoA; β-Hydroxy-β-methylglutaryl-coenzyme A. CAS No. 1553-55-5. Molecular formula: C27H44N7O20P3S. Mole weight: 911.66. | |
| HMHA-Gln | HMHA-Gln. Synonyms: HMHA Gln; Nα-3-methyl-3-hydroxy-hexanoyl-glutamine. Molecular formula: C12H22N2O5. Mole weight: 274.31. | |
| HMMNI | HMMNI is a metabolite of dimetridazole. Dimetridazole is an antibacterial and anticoccidial agent that is once widely used for the treatment of parasitic infections in livestock. Synonyms: 2-Hydroxymethyl-1-methyl-5-nitro-1H-imidazole; (1-Methyl-5-nitroimidazol-2-yl)methanol. CAS No. 936-05-0. Molecular formula: C5H7N3O3. Mole weight: 157.1. | |
| HMN-154 | HMN-154, a novel benzenesulfonamide anticancer drug, inhibits KB (IC50= 0.0026 μg/mL) and colon38 cells (IC50= 0.003 μg/mL). Synonyms: 4-methoxy-N-[2-[(E)-2-pyridin-4-ylethenyl]phenyl]benzenesulfonamide; (E)-4-(2-(2-p-methoxy-benzene-sulfonamide) phenyl)(ethenyl ) pyridine; HMN-154; HMN 154; HMN154. CAS No. 173528-92-2. Molecular formula: C20H18N2O3S. Mole weight: 366.43. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. Synonyms: HMN 176; HMN176; (E)-4-(2-(2-(N-((p-Methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. | |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Synonyms: HMN-214; HMN 214. CAS No. 173529-46-9. Molecular formula: C22H20N2O5S. Mole weight: 424.471. | |
| HM Pectin | HM Pectin. | |
| HMR 1031 | HMR 1031 is a potent and specific integrin α4β1 or very late antigen 4 (VLA-4) receptor antagonist binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin. HMR1031 has the potential used as an inhaled drug for the treatment of asthma. Uses: Potential inhaled drug for asthma. Synonyms: HMR-1031; HMR 1031; HMR1031; Rnm7wqo98Y; (3S)-3-[[(2S)-2-[4,4-dimethyl-3-[[4-[(2-methylphenyl)carbamoylamino]phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-4-methylpentanoyl]amino]-3-phenylpropanoic acid. Grade: 98%. CAS No. 479203-71-9. Molecular formula: C35H41N5O6. Mole weight: 627.73. | |
| HMR 1098 | HMR 1098 is a KATP channel antagonist inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels. Synonyms: HMR 1098; HMR1098; HMR-1098; 5-chloro-2-methoxy-n-[2-[4-methoxy-3-(3-methylthioureidosulfonyl)phenyl]ethyl]benzamide sodium salt. Grade: 98%. CAS No. 261717-22-0. Molecular formula: C19H21ClN3NaO5S2. Mole weight: 493.96. | |
| HMR 1556 | HMR 1556 is a potent and selective Iks channel blocker (IC50 = 10.5 and 34 nM in canine and guinea pig ventricular myocytes, respectively). It selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. HMR 1556 also exhibits weak activity at Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. HMR 1556 is used in the treatment of proarrythmia. Uses: The treatment of proarrythmia. Synonyms: HMR-1556; HMR 1556; HMR1556.N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide. Grade: ≥98% by HPLC. CAS No. 223749-46-0. Molecular formula: C17H24F3NO5S. Mole weight: 411.44. | |
| HMR 1826 | HMR 1826 is a heterodimeric lucuronide prodrug of doxorubicin, an anthracycline antibiotic commonly used to treat various cancers. Synonyms: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; (8S-cis)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; Doxorubicin-glucuronide. Grade: ≥95%. CAS No. 148580-25-0. Molecular formula: C41H42N2O22. Mole weight: 914.77. | |
| HNGF6A | HNGF6A is a humanin analog that increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. HNGF6A enhances glucose sensing in βTC3 cells and decreases blood glucose level in Zucker diabetic fatty rats. HNGF6A is used for the prevention of endothelial dysfunction and atherosclerosis in vivo. Uses: The prevention of endothelial dysfunction and atherosclerosis. Synonyms: HNGF6A; 1093111-54-6; AKOS024458518; PD079802. CAS No. 1093111-54-6. Molecular formula: C112H198N34O31S2. Mole weight: 2581.13. | |
| HNHA | HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) (IC50 = 100 nM). HNHA exhibits activity aganist various cancers like breast cancer and anaplastic thyroid cancer (ATC). Synonyms: Histone Deacetylase Inhibitor VI; N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide. Grade: ≥98%. CAS No. 926908-04-5. Molecular formula: C17H21NO2S. Mole weight: 303.4. | |
| HNMPA | HNMPA is a cell-impermeable insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethyl phosphonic acid. Grade: ≥95%. CAS No. 132541-52-7. Molecular formula: C11H11O4P. Mole weight: 238.2. | |
| HNMPA-(AM)3 | HNMPA-(AM)3 is a cell-permeable analog of HNMPA, an insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester. Grade: ≥95%. CAS No. 120944-03-8. Molecular formula: C20H23O10P. Mole weight: 454.4. | |
| hnps-PLA-IN-1 | hnps-PLA-IN-1 is an inhibitor of human nonpancreatic secretory Phospholipase A. Synonyms: hnps-PLA Inhibitor; 2-(4-(2-Amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide; 2-{[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetamide. CAS No. 185298-58-2. Molecular formula: C21H21N3O4. Mole weight: 379.41. | |
| hnRNPK-IN-1 | hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kds of 4.6 and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-Myc transcription by disrupting the binding of hnRNPK and c-Myc promoter. It inducs apoptosis of Hela cells and shows strongly antitumor activity. Synonyms: 2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)-; (2E)-1-(4-Methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-2-propen-1-one. Grade: ≥97%. CAS No. 2313528-04-8. Molecular formula: C23H21N3O5. Mole weight: 419.43. | |
| HO-3867 | HO-3867 is a selective and potent STAT3 inhibitor that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 exhibited minimal toxicity toward noncancerous cells and tissues but induced apoptosis in ovarian cancer cells. Synonyms: HO 3867; EX-A2319; (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one. Grade: >98%. CAS No. 1172133-28-6. Molecular formula: C28H30F2N2O2. Mole weight: 464.557. | |
| Hodgkinsine B | Hodgkinsine B is an alkaloid and isomer of hodgkinsine which has analgesic activity. It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg. Synonyms: (-)-Hodgkinsine B. Grade: >95% by HPLC. CAS No. 586955-76-2. Molecular formula: C33H38N6. Mole weight: 518.69. | |
| HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt | HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt has inhibitory activity against pre-miR-21 RNA, and has the potential for the research of neoplastic disease such as cancer and especially cancers expressing miR-21. (Extracted from patent WO2021087084A1, compound 25). CAS No. 2641500-83-4. Molecular formula: C57H62N8O10S. Mole weight: 1051.21. | |
| HOIPIN-1 | HOIPIN-1 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor that suppresses the LUBAC-induced linear ubiquitination and NF-κB target gene expression. Synonyms: JTP 0819958; EX-A5121; Sodium (E)-2-(3-(2-methoxyphenyl)-3-oxoprop-1-enyl)benzoate. Grade: 99%. Molecular formula: C17H13NaO4. Mole weight: 304.27. | |
| HOIPIN 11a | HOIPIN 11a is a selective and cell-permeable inhibitor of the RBR E3 ubiquitin ligase HOIP. Synonyms: GSK11a; (E)-Methyl 4-(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamido)but-2-enoate. Grade: 99%. CAS No. 1610800-91-3. Molecular formula: C15H18N2O4. Mole weight: 290.31. | |
| HOIPIN-8 | HOIPIN-8 is an inhibitor of LUBAC and NF-κB signaling without cytotoxicity with IC50 of 11 nM. HOIPIN-8 is a powerful tool to explore the physiological functions of LUBAC. Synonyms: Sodium (E)-2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-enyl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate. Grade: >95%. Molecular formula: C23H15F2N4NaO3. Mole weight: 456.38. | |
| Hoku-81 | Hoku 81 is a bronchodilator, and one of the metabolites of tulobuterol. Uses: Bronchodilators,metabolite of tulobuterol. Synonyms: Hoku 81; Hoku-81; Hoku81. 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol; 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-benzenemethanol; 4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol. Grade: ≥98%. CAS No. 58020-43-2. Molecular formula: C12H18ClNO2. Mole weight: 243.73. | |
| Homatropine HBr | Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. Synonyms: DL-endo-α-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide; DL-Homatropine hydrobromide; Tropine mandelate hydrobromide; alpha-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide; rac Homatropine. Grade: >98%. CAS No. 51-56-9. Molecular formula: C16H21NO3.HBr. Mole weight: 356.25. | |
| Homatropine methylbromide | Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. Synonyms: Homatropine Methylbromide; Omatropina metilbromuro; 8-Methylhomatropinium bromide; Homatropine methobromide; Homatropine methyl bromide; AC1L1MZP; Methylhomatropine. Grade: >98%. CAS No. 80-49-9. Molecular formula: C17H24BrNO3. Mole weight: 370.28. | |
| Homoalanosine | Homoalanosine is an amino acid analogue and a derivative of alanosine, an antibiotic used in the treatment of pancreatic cancer. Grade: 98%. CAS No. 114707-36-7. Molecular formula: C4H9N3O4. Mole weight: 163.13. | |
| Homocarnosine acetate | L-Homocarnosine is a human metabolite and a brain-specific dipeptide of γ-aminobutyric acid (GABA) and histidine. Synonyms: L-Homocarnosine acetate. Grade: 98%. Molecular formula: C12H20N4O5. Mole weight: 300.31. | |
| Homocysteine-penicillamine disulfide | An impurity of Penicillamine which is an antirheumatic and a chelating agent in Wilson's disease. Grade: > 95%. Molecular formula: C9H18N2O4S2. Mole weight: 282.38. | |
| Homo Egonol β-D-Glucoside | A nor-Lignan from Styrax ferrugineus with antibacterial and antifungal activity. Uses: A nor-lignan from styrax ferrugineus with antibacterial and antifungal activity. Synonyms: 3-[2-(3,4-Dimethoxyphenyl)-7-methoxy-5-benzofuranyl]propyl β-D-Glucopyranoside. CAS No. 325791-19-3. Molecular formula: C26H32O10. Mole weight: 504.53. | |
| Homofuraneol β-D-glucopyranoside | Homofuraneol β-D-glucopyranoside is a glucoside derivative of homofuraneol, which is a type of high-impact aroma chemical. This compound is formed by the attachment of a β-D-glucopyranosyl group to homofuraneol, enhancing its water solubility and structural stability. Synonyms: 5-Ethyl-4-(β-D-glucopyranosyloxy)-2-methyl-3(2H)-furanone; 4-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy]-5-ethyl-2-methyl-2H-furan-3-one; 4-O-(β-D-Glucopyranosyl)-4-hydroxy-5-ethyl-2-methyl-3(2H)-furanone. Grade: ≥98%. Molecular formula: C13H20O8. Mole weight: 304.29. | |
| Homopravastatin sodium salt | An impurity of Pravastatin. Pravastatin is a member of the drug class of statins. It can be used for lowering cholesterol and preventing cardiovascular disease. Synonyms: Pravastatin EP Impurity C sodium salt; Pravastatin Impurity C sodium salt; (3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[[(2S)-2-methylpentanoyl]oxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid sodium salt; DES(2-methylbutanoyl)-2-methylpentanoyl pravastatin sodium salt; (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[[(2S)-2-methyl-1-oxopentyl]oxy]-1-naphthaleneheptanoic acid sodium salt; 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[[(2S)-2-methyl-1-oxopentyl]oxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)-; 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2-methyl-1-oxopentyl)oxy]-, monosodium salt, [1S-[1α(βS*,εS*),2α,6α,8β(R*)]]-; Pravastatin pentanoyl impurity sodium salt. Grade: >95%. CAS No. 159225-12-4. Molecular formula: C24H37NaO7. Mole weight: 460.55. | |
| Homoquinolinic acid | Homoquinolinic acid is a potent NMDA receptor agonist and neurotoxic agent. Synonyms: 3-Pyridineacetic acid, 2-carboxy-; 2-carboxy-3-Pyridineacetic acid; Homoquinolinate; 3-(carboxymethyl)pyridine-2-carboxylic acid. Grade: ≥99% by HPLC. CAS No. 490-75-5. Molecular formula: C8H7NO4. Mole weight: 181.15. | |
| Homosalate | Homosalate could be commonly useful in sorts of cosmetics acting as a chemical UV filter. Uses: Homosalate could be commonly useful in sorts of cosmetics acting as a chemical uv filter. Synonyms: SALICYLIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER; trimethylcyclohenyl salicylate; Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester; Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester; component of Coppertone; Coppertone; Filtersol ''A''; Filtrosol A. Grade: 98%. CAS No. 118-56-9. Molecular formula: C16H22O3. Mole weight: 262.35. | |
| Homoveratric acid acyl-β-D-glucuronide | Homoveratric acid acyl-β-D-glucuronide is a metabolite of Homoveratric acid, which is a significant compound used as a pharmaceutical intermediate and has been implicated in neurotransmitter metabolism, neuroprotection, and the alleviation of depression. It is also associated with the gut microbiome, suggesting a role in mental health through its influence on neurotransmitter levels and synaptic integrity. Synonyms: 1-(3,4-Dimethoxybenzeneacetate) β-D-glucopyranuronic acid, Homoveratrate β-D-glucopyranuronic acid; (2S,3S,4S,5R,6S)-6-[(3,4-Dimethoxyphenyl)acetoxy]-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Grade: ≥98%. Molecular formula: C16H20O10. Mole weight: 372.32. | |
| Homo-VK-II-36 | Homo-VK-II-36 is a novel carvedilol analog that inhibits store- overload- induced calcium release (SOICR) through the RyR2 channel. Synonyms: Homo VK II 36; HomoVKII36; 3-Morpholinone, 6-[2-(9H-carbazol-4-yloxy)ethyl]-4-[2-(2-methoxyphenoxy)ethyl]-; 6-(2-((9H-Carbazol-4-yl)oxy)ethyl)-4-(2-(2-methoxyphenoxy)ethyl)morpholin-3-one. Grade: >98%. CAS No. 1479049-35-8. Molecular formula: C27H28N2O5. Mole weight: 460.52. | |
| Honokiol | Honokiol is a polyphenol found in the genus Magnolia. Honokiol acts as an Akt inhibitor and also inhibits NF-κB, displaying anti-inflammatory, antiangiogenic and antitumor properties. It results in inhibition of bone metastatic growth of human prostate cancer cells. Honokiol has obvious antioxidant and anti-aging effects, thus can be used in cosmetic material. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. It has the activity of antibacterial, anti-inflammatory, antioxidant, oil control, acne, promoting healing, and can be widely used in anti-acne, deodorization, acne and other products. Uses: Anti-inflammatory and anti-cancer agent. Synonyms: Honokiol; 35354-74-6; 5,3'-Diallyl-2,4'-dihydroxybiphenyl; NSC 293100; 3,5'-Diallyl-4,2'-dihydroxybiphenyl; 3',5-Diallylbiphenyl-2,4'-diol; C18H18O2; 3',5-diallyl-2,4'-biphenyldiol; CPD000387107; CHEMBL16901; 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol; CHEBI:5759; 4-allyl-2-(3-allyl-4-hydroxy-phenyl)phenol; 11513CCO0N; 2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol; 5,3. Grade: ≥98%. CAS No. 35354-74-6 | |
| Hoquizil hydrochloride | Hoquizil hydrochloride is a new oral bronchodilator. Synonyms: (2-hydroxy-2-methylpropyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate; hydrochloride; Hoquizil hydrochloride; Hoquizil HCl; CP-14,185-1; CP-14185-1. Grade: >98%. CAS No. 23256-28-2. Molecular formula: C19H27ClN4O5. Mole weight: 426.89. | |
| Horseradish peroxidase | Peroxidase is a heme-containing enzyme, and it can be used to oxidize a wide variety of substrates. Synonyms: HRP; Peroxidase. CAS No. 9003-99-0. | |
| HP1142 | HP1142, a benzoimidazole scaffold-based compound, is a potent and selective FLT3 receptor tyrosine kinase (FLT3/ITD mutation) inhibitor. It has the potential for the study of FLT3/ITD leukemia. Synonyms: N-(3,4-dimethoxybenzyl)-1-phenyl-1H-benzimidazol-5-amine; 1H-Benzimidazol-5-amine, N-[(3,4-dimethoxyphenyl)methyl]-1-phenyl-. Grade: ≥95%. CAS No. 381173-58-6. Molecular formula: C22H21N3O2. Mole weight: 359.42. | |
| HP1328 | HP1328, a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation), significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia. Synonyms: Ethanol, 2-[2-methoxy-4-[[(1-phenyl-1H-benzimidazol-5-yl)amino]methyl]phenoxy]-. CAS No. 2245074-20-6. Molecular formula: C23H23N3O3. Mole weight: 389.45. | |
| HPGDS-inhibitor-1 | HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM. Synonyms: MDK36122; MDK36122; MDK-36122; H-PGDS Inhibitor I; Prostaglandin D Synthase (hematopoietic-type) Inhibitor I. CAS No. 1033836-12-2. Molecular formula: C19H19F4N3O. Mole weight: 381.3746. | |
| H-Phe(4-Ac)-OH HCl | H-Phe(4-Ac)-OH HCl, an essential chemical for a wide range of pharmaceutical and peptide synthesis, boasts exceptional adequacy as a constituent for drug production. This product serves as a key reagent as well as a fundamental building block in the synthesis of peptide-based medications. Medical professionals and researchers commonly employ H-Phe(4-Ac)-OH HCl as an effective measure in the treatment of chronic pain and inflammation arising due to a multitude of conditions, including but not limited to osteoarthritis and rheumatoid arthritis. Synonyms: 4-Acetyl-L-phenylalanine Hydrochloride; 4-Acetylphenylalanine hydrochloride; (S)-3-(4-Acetylphenyl)-2-aminopropanoic acid HCl; p-Acetylphenylalanine hydrochloride. CAS No. 20299-31-4. Molecular formula: C11H14ClNO3. Mole weight: 243.68. | |
| HPI 1 | HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation) with no effect on Wnt signaling. HPI 1 also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM), and prevents the proliferation of cerebellar granule neuron precursors expressing SmoM2. Synonyms: HPI 1; HPI1; HPI-1; 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester. Grade: ≥95% by HPLC. CAS No. 599150-20-6. Molecular formula: C27H29NO6. Mole weight: 463.52. | |
| HPK1-IN-10 | HPK1-IN-10 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 103. HPK1-IN-10 has the potential for the research of HPK1 related diseases. CAS No. 2734168-69-3. Molecular formula: C31H34N6O2. Mole weight: 522.64. | |
| HPK1-IN-11 | HPK1-IN-11 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 2. HPK1-IN-11 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer. CAS No. 2734167-68-9. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| HPK1-IN-12 | HPK1-IN-12 is a potent inhibitor of HPK1 extracted from patent WO2021213317A1, compound 85. HPK1-IN-12 has the potential for the research of HPK1 related diseases. Uses: Hpk1-in-12 is a potent inhibitor of hpk1, a serine/threonine protein kinase that is involved in the regulation of cell growth and differentiation. it is being investigated for its potential use in the treatment of cancer and other diseases. Synonyms: N-(4-fluorobenzyl)-6-(2-hydroxy-5-nitrobenzylidene)-2-methyl-4-pyrimidinamine. CAS No. 2734168-51-3. Molecular formula: C25H24FN5O2. Mole weight: 445.49. | |
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