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| Product | Description | |
|---|---|---|
| Prednisolone EP Impurity I | Prednisolone EP Impurity I is an impurity of Prednisolone, which is a glucocorticoid and an anti-inflammatory drug used to treat central nervous system disorders. Synonyms: 17-Deoxy Prednisolone; 1,2-Didehydrocorticosterone; 11β,21-Dihydroxypregna-1,4-diene-3,20-dione; 17-Deoxyprednisolone; Δ1-Corticosterone; 17-Dehydroxy Prednisolone; (11β)-11,21-Dihydroxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-, (11β)-; Dehydrocorticosterone. Grades: ≥95%. CAS No. 13479-38-4. Molecular formula: C21H28O4. Mole weight: 344.44. |  |
| Prednisolone Pivalate | Prednisolone Pivalate is a metabolite of Prednisolone, which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. Synonyms: 11β,17α-Dihydroxy-21-pivaloyloxypregna-1,4-diene-3,20-dione; Mecortolon; PTMA; Prednisolone 21-pivalate; Prednisolone 21-Trimethylacetate; Prednisolone Pivalate; Prednisolone Trimethylacetate; Ultracortenol; Ultracorterenol; Vecortenol. Grades: 95%. CAS No. 1107-99-9. Molecular formula: C26H36O6. Mole weight: 444.56. | |
| Prednisolone Sodium Phosphate Isomer II | Prednisolone Sodium Phosphate Isomer II is an impurity of Prednisolone, which is a glucocorticoid and an anti-inflammatory drug used to treat central nervous system disorders. Synonyms: Prednisolone sodium phosphate Isomer 2; 17,21-dihydroxy-3,20-dioxopregna-1,4-dien-11β-yl disodium phosphate. Molecular formula: C21H27Na2O8P. Mole weight: 484.39. | |
| Prednisolone Tebutate | Prednisolone tebutate is a synthetic glucocorticoid used as an antiinflammatory and immunosuppressant. Synonyms: 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(3,3-Dimethylbutyrate); 3,3-Dimethylbutyric Acid 21-Ester with 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(3,3-dimethylbutyrate); Codelcortone TBA; Hydeltra TBA; Predalone TBA; Prednisolone 21-tert-Butylacetate; Prednisolone TBA; Prednisolone Tebutate; Prednisolone tert-Butylacetate. Grades: ≥95%. CAS No. 7681-14-3. Molecular formula: C27H38O6. Mole weight: 458.59. | |
| Prednisone Impurity 1 | An impurity of Prednisone. Prednisone is a synthetic corticosteroid drug. It can be used for the treatment of certain inflammatory diseases, some autoimmune diseases, and (at higher doses) some types of cancer. Synonyms: 9beta,11beta-Epoxy-17,21-dihydroxypregna-1,4-diene-3,20-dione. Grades: > 95%. CAS No. 7091-5-6. Molecular formula: C21H26O5. Mole weight: 358.44. | |
| Predocol | Predocol is a derivative of Prednisolone, which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. Synonyms: 11,17-Dihydroxy-21-[(3-sulfobenzoyl)oxy]-pregna-1,4-diene-3,20-dione Sodium Salt; ATL 2502; Cortico-Sol; Predenema; Predfoam; Prednisolone 21-m-sulfobenzoate sodium; Prednisolone 21-m-sulfobenzoate sodium salt; Prednisolone metasulfobenzoate sodium; Prednisolone sodium metasulfobenzoate; Prednisolone sodium metazoate; Prednisolone Sodium 21-Metasulfobenzoate. Grades: 95%. CAS No. 630-67-1. Molecular formula: C28H31NaO9S. Mole weight: 566.59. | |
| Preladenant | Preladenant is a potent adenosine A2 receptor antagonist that has been studied as a therapeutic agent for Parkinson's disease. Synonyms: SCH420814; SCH-420814; SCH 420814; MK-3814; MK 3814; MK3814; Preladenant2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amine. Grades: >98%. CAS No. 377727-87-2. Molecular formula: C25H29N9O3. Mole weight: 503.56. | |
| Presatovir | Presatovir is a viral fusion protein inhibitor with EC50 value of 0.43 nM. It can inhibit a broad range of respiratory syncytial virus clinical isolates by blocking the virus-cell fusion process. It can also inhibit pre- to post-fusion conformational changes of the respiratory syncytial virus fusion protein. Phase II clinical trials for the treatment of respiratory syncytial virus infections is ongoing. Synonyms: N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide; GS-5806; GS5806; GS 5806. Grades: >98%. CAS No. 1353625-73-6. Molecular formula: C24H30ClN7O3S. Mole weight: 532.06. | |
| Pridopidine | Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders. Uses: Dopamine d2 receptor antagonists; glutamate modulators; sigma-1 receptor agonists. Synonyms: 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine; ACR 16; ACR16; ACR-16; FR310826; FR-310826; FR 310826; 4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine. Grades: ≥98%. CAS No. 346688-38-8. Molecular formula: C15H23NO2S. Mole weight: 587.71. | |
| Probucol Disuccinate | Probucol Disuccinate is the succinate ester form of probucol, which is a potent oxidant. Probucol inhibits the oxidantion of cholesterol in LDLs, and also lowers HDL in patients with heart disease. Probucol is used as an anti-hyperlipidemic drug. Synonyms: 4-[2, 6-ditert-butyl-4-[2-[3, 5-ditert-butyl-4- (3-carboxypropanoyloxy) phenyl]sulfanylpropan-2-ylsulfanyl]phenoxy]-4-oxobutanoic acid. CAS No. 216168-45-5. Molecular formula: C39H56O8S2. Mole weight: 716.989. | |
| Procinonide | Synonyms: 6Alpha,9-Difluoro-11Beta-Hydroxy-16Alpha,17-(Isopropylidenebis(Oxy))Pregna-1,4-Diene-3,20-Dione 21-Propionate; 6α,9-Difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; RS-2362. Grades: > 95%. CAS No. 58497-00-0. Molecular formula: C27H34F2O7. Mole weight: 508.56. | |
| Procymidone | Procymidone is a pesticide. It can be used for killing unwanted ferns and nettles, and as a dicarboximide fungicide for killing fungi. Uses: Fungicides, industrial. Synonyms: 1, 2-Dimethyl-N- (3, 5-dichlorophenyl) cyclopropanedicarboximide; Dicyclidine; Dicyclidine; Kenolex; Procilex; Procymidone; Procymidor; Procymidox; Salithiex; Sialex; Sumilex; Sumilex; Sumisclex. Grades: > 95%. CAS No. 32809-16-8. Molecular formula: C13H11Cl2NO2. Mole weight: 284.14. | |
| Progesterone 6-Oxo Impurity | An impurity of Progesterone. Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. Synonyms: 6-Ketoprogesterone; Pregn-4-ene-3,6,20-trione; 6-Oxoprogesterone. Grades: > 95%. CAS No. 2243-8-5. Molecular formula: C21H28O3. Mole weight: 328.46. | |
| Progesterone EP Impurity C | An impurity of Progesterone.Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. Synonyms: (20R)-20-Hydroxy-pregn-4-en-3-one; 20β-Dihydroprogesterone; 20β-Hydroxy-Δ4-pregnen-3-one; 20β-Hydroxypregn-4-en-3-one; 20β-Hydroxyprogesterone; 20β-Progerol; 4-Pregnene-20β-ol-3-one; Pregn-4-en-20β-ol-3-one; Pregn-4-ene-20β-hydroxy-3-one; Progesterol-20β; Δ4-Pregnen-20β-ol-3-one; Δ4-Pregnene-20β-ol-3-one; 20β-Dihydroprogesterone. Grades: ≥95%. CAS No. 145-15-3. Molecular formula: C21H32O2. Mole weight: 316.49. | |
| Progesterone EP Impurity G | An impurity of Progesterone.Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. Synonyms: Progesterone impurity G [EP]; 21-(Cyclohexylidene)pregn-4-ene-3,20-dione; Pregn-4-ene-3,20-dione, 21-cyclohexylidene-. Grades: ≥95%. CAS No. 2257421-79-5. Molecular formula: C27H38O2. Mole weight: 394.59. | |
| Progesterone EP Impurity I | Progesterone EP Impurity I is an impurity of Progesterone, which is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Synonyms: (20RS)-20-methyl-3-oxopregn-4-en-21-al; Pregn-4-ene-20-carboxaldehyde, 3-oxo-; 3-Oxopregn-4-ene-20-carboxaldehyde; 3-Oxopregnen-4-ene-20-carboxaldehyde; 20-Formylpregn-4-en-3-one; Progesterone Impurity I; (RS)-2-((8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanal. Grades: ≥95%. CAS No. 24254-01-1. Molecular formula: C22H32O2. Mole weight: 328.49. | |
| Progesterone Impurity D | Cas No. 5035-9-6. | |
| Prop-2-yn-1-yl 2-cyclohexyl-2-phenyl-2-(prop-2-yn-1-yloxy)acetate | Prop-2-yn-1-yl 2-cyclohexyl-2-phenyl-2-(prop-2-yn-1-yloxy)acetate is an intermediate in the synthesis of Oxybutynin, which is a medication used to treat overactive bladder. Molecular formula: C20H22O3. Mole weight: 310.39. | |
| Propan-2-yl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-[4-(propan-2-yloxy)-4-oxobutanamido]butanoate | Propan-2-yl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-[4-(propan-2-yloxy)-4-oxobutanamido]butanoate is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: Isopropyl (2R,4S)-5-(4-biphenylyl)-4-[(4-isopropoxy-4-oxobutanoyl)amino]-2-methylpentanoate. CAS No. 2216755-67-6. Molecular formula: C28H37NO5. Mole weight: 467.6. | |
| Propicillin | Propicillin is a derivative of Penicillin. Penicillin belongs to the β-lactam class of antibiotics, is a very common antibacterial drug. Synonyms: 3,3-Dimethyl-7-oxo-6-(2-phenoxybutyramido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (1-Phenoxypropyl)penicillin; [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amino]-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Synthepen P; α-Phenoxybutyryl-6-aminopenicillanic acid; α-Phenoxypropylpenicillin; B-Pimaric Acid; A-pimaric acid. Grades: ≥95%. CAS No. 551-27-9. Molecular formula: C18H22N2O5S. Mole weight: 378.44. | |
| Propionyl-L-Carnitine HCl | The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Uses: The hydrochloride salt form of l-propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases. Synonyms: PROPIONYL-L-CARNITINE CHLORIDE;PROPIONYL L-CARNITINE HCL;PROPIONYL-L-CARNITINE HYDROCHLORIDE;PROPIONYL-LEVO-CARNITINE HYDROCHLORIDE;(r)-2-propionyl-3-(trimethylaminium)butanoic acid chloride;Propionyl L-Carnitine. Grades: 95%. CAS No. 119793-66-7. Molecular formula: C10H20ClNO4. Mole weight: 253.73. | |
| Propofol Impurity E | An impurity of Propofol.Propofol is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Synonyms: 3,3',5,5'-Tetrakis(1-methylethyl)-[1,1'-biphenyl]-4,4'-diol; 2,2',6,6'-Tetraisopropyl-p,p'-biphenol; 3,3',5,5'-Tetraisopropyl-4,4'-dihydroxybiphenyl; Propofol EP Impurity E; Dipropofol. Grades: > 95%. CAS No. 2416-95-7. Molecular formula: C24H34O2. Mole weight: 354.54. | |
| Propoxycaine Hydrochloride | Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine, which is a local anesthetic used to control the pain of intramuscular injections of penicillin as well as in dentistry. Uses: A local anaesthetic. Synonyms: 4-Amino-2-propoxybenzoic Acid 2-(Diethylamino)ethyl Ester Monohydrochloride; 2-Diethylaminoethyl 4-Amino-2-propoxybenzoate Hydrochloride; 2'-Diethylaminoethyl 2-Propoxy-4-aminobenzoate Hydrochloride; Blockaine Hydrochloride; Pravocaine Hydrochloride; Propoxycaine Hydrochloride; Ravocaine Hydrochloride; Propoxycaine HCl; Blockain. Grades: 97%. CAS No. 550-83-4. Molecular formula: C16H27ClN2O3. Mole weight: 330.85. | |
| Prostaglandin F2α tromethamine salt | Prostaglandin F2α is a naturally-occurring prostaglandin and potent vasoconstrictor, exhibiting luteolytic activity. Uses: Abortifacient agents, nonsteroidal. Synonyms: U 14585; U14585; U-14585; Dinoprost tromethamine salt; Dinolytic; Zinoprost; Prostin F2 alpha. Grades: ≥98%. CAS No. 38562-01-5. Molecular formula: C20H34O5.C4H11NO3. Mole weight: 475.62. | |
| Protease-Activated Receptor-2 Activating Peptide | LIGRL-NH2 is a PAR2 activator with EC50 value of ~5 μM. It can be used to explore signaling through PAR2 in cells. Synonyms: Thrombin Receptor-Like 1 (1-6) amide (mouse, rat); SLIGRL amide; Proteinase Activated Receptor 2 (1-6) amide (mouse, rat); Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat); PAR-2 (1-6) amide (mouse, rat); Ser-Leu-Ile-Gly-Arg-Leu-NH2; L-Seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucinamide. Grades: 98%. CAS No. 171436-38-7. Molecular formula: C29H56N10O7. Mole weight: 656.82. | |
| Protease-Activated Receptor-2, amide | SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM; IC50 = 10.4 μM). Synonyms: Thrombin Receptor-Like 1 (1-6) amide (human); SLIGKV amide; Proteinase Activated Receptor 2 (1-6) amide (human); Coagulation Factor II Receptor-Like 1 (1-6) amide (human); Ser-Leu-Ile-Gly-Lys-Val; PAR2 activating peptide; PAR2-AP; PAR-2 (1-6) Human; L-seryl-L-leucyl-L-isoleucyl-glycyl-L-lysyl-L-valinamide. Grades: 98%. CAS No. 190383-13-2. Molecular formula: C28H54N8O7. Mole weight: 614.78. | |
| Protein Kinase Inhibitors 1 | Protein Kinase Inhibitors 1 is a HIPK2 inhibitor with IC50 of 74 nM and Kd of 9.5 nM. Synonyms: 2,4-Thiazolidinedione, 5-[[1,2-dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-; 5-((2-oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione; 5-[[1,2-Dihydro-2-oxo-6'-(1-piperazinyl)[3,3'-bipyridin]-5-yl]methylene]-2,4-thiazolidinedione. Grades: ≥95%. CAS No. 1365986-44-2. Molecular formula: C18H17N5O3S. Mole weight: 383.43. | |
| Protoporphyrin IX | Created by the enzyme protoporphyrinogen oxidase, protoporphyrin IX is an important precursor to biologically essential prosthetic groups. Uses: Metabolism of porphyrin. Synonyms: Protoporphyrin; 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid. Grades: ≥95%. CAS No. 553-12-8. Molecular formula: C34H34N4O4. Mole weight: 562.66. | |
| PS-1145 | PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; PS-1145; PS 1145; PS1145. Grades: 98%. CAS No. 431898-65-6. Molecular formula: C17H11ClN4O. Mole weight: 322.75. | |
| PSI-7976 | PSI-7976 is an inhibitor of HCV RNA replication with EC50 value of 1.07μM. PSI-7851 is a phosphoramidate prodrug of PSI-7411 and has potent anti-hepatitis C virus (HCV) activity. It is a mixture of two diastereoisomers. PSI-7976 is one of them. Another one is PSI-7977. PSI-7851 is firstly activated through being hydrolyzed by CatA and CES1in the liver cells. It is found that CatA prefers PSI-7977 as a substrate over PSI-7976 while CES1 preferentially hydrolyzes PSI-7976 over PSI-7977. Since CES1 does not express in clone A replicon cells, the ability of PSI-7976 and PSI-7977 to inhibit HCV RNA replication is different in these cells. PSI-7977 is more potent than PSI-7976 with EC50 value of 92nM. Synonyms: Sofosbuvir (R)-Phosphate; (2S)-Isopropyl 2- ( ( ( ( (2R, 3R, 4R, 5R) -5- (2, 4-Dioxo-3, 4-dihydropyrimidin-1 (2H) -yl) -4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl) methoxy) (phenoxy) phosphoryl) amino) propanoate; N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester. Grades: >98%. CAS No. 1190308-01-0. Molecular formula: C22H29FN3O9P. Mole weight: 529.45. | |
| PT-2385 | PT-2385 is a small molecule inhibitor with oral activity that inhibits hypoxia inducible factor (HIF)-2alpha heterodimerization and its subsequent binding to DNA by binding to HIF-2alpha. Synonyms: 3-[[(1S)-2,2-difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrilePT-2385; PT2385; PT 2385SCHEMBL165558103-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile79A. CAS No. 1672665-49-4. Molecular formula: C17H12F3NO4S. Mole weight: 383.34. | |
| PTC-209 | PTC-209 is a potent BMI-1 inhibitor with potential anticancer activity. PTC-209 inhibits endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. Synonyms: PTC-209; PTC 209; PTC209. CAS No. 315704-66-6. Molecular formula: C17H13Br2N5OS. Mole weight: 495.19. | |
| Pteroic Acid | Cas No. 119-24-4. | |
| PX-478 dihydrochloride | PX-478 is an HIF-1alpha inhibitor and an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. It is rapidly absorbed following oral and i.p. administration and gives excellent Cmax and AUC via these routes. Synonyms: PX-478 2HCl; PX-478 hydrochloride; Melphalan N-Oxide Impurity HCl; Melphalan N-Oxide Impurity hydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2). Grades: > 98%. CAS No. 685898-44-6. Molecular formula: C13H18Cl2N2O3.2HCl. Mole weight: 394.1. | |
| PXS 4728A | PXS 4728A is a VAP-1 (aka SSAO/AOC3) inhibitor with IC50 values 5 nM in the clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). Studies show that it inhibits neutrophil rolling and tethering in mouse cremaster model, and alleviates respiratory inflammation in multiple models. Uses: Treatment of non-alcoholic steatohepatitis (nash). Synonyms: BI-1467335 HCl; (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride. Grades: 98%. CAS No. 1478364-68-9. Molecular formula: C15H21FN2O2.HCl. Mole weight: 316.8. | |
| [Pyr1]-Apelin-13 | [Pyr1]-Apelin-13 is the highly potent pyroglutamylated form of apelin-13, which is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 0.37 nM. It is the major apelin form in human plasma and heart, which the N-terminal glutamine residue is cyclized to pyroglutamic acid. It exhibits higher APJ agonist potency than Apelin-13. It has antipyretic and vasoconstrictor effects in vitro and in vivo. It is widely used for studying APJ-mediated cellular and physiological functions both in cultures and in animals in vivo. It is reactive toward human, rat, bovine and murine species. Synonyms: [Pyr1]-Apelin-13; [Pyr1]-Apelin13; [Pyr1]-Apelin 13; 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; Pyroglutamated apelin-13; [pGlu1]-apelin-13. Grades: 98%. CAS No. 217082-60-5. Molecular formula: C69H108N22O16S. Mole weight: 1533.81. | |
| Pyrithiamine hydrobromide | Pyrithiamine is an analog of thiamine and acts as a substrate for thiamine pyrophosphokinase. It inhibits thiamine metabolism and induces neurological symptoms similar to that of Wernicke-Korsakoff Syndrome in animals. Uses: Antimetabolites. Synonyms: 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium-3-yl]ethanol;bromide;hydrobromide. Grades: ≥ 95 %. CAS No. 534-64-5. Molecular formula: C14H18N4O ยท 2HBr. Mole weight: 420.14. | |
| Pyronaridine | Pyronaridine is an antimalarial drug. Pyronaridine was first synthesized in 1970 and has been in clinical use in China since the 1980s. It is one of the components of the artemisinin combination therapy pyronaridine artesunate (Pyramax). Uses: Antimalarial. Synonyms: 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine;76748-86-2(Pyronaridine tetraphosphate). Grades: 98%. CAS No. 74847-35-1. Molecular formula: C29H32ClN5O2. Mole weight: 518.04968. | |
| Pyronaridine Tetraphosphate | Pyronaridine tetraphosphate is an antimalarial agent with an inhibitory effect on P-glycoprotein mediated drug resistance. It inhibits B-hematin formation and Ebola virus (EBOV). Uses: Antimalarial agent. Synonyms: Pyranoridine phosphate; Pyronaridine phosphate; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one;phosphoric acid. CAS No. 76748-86-2. Molecular formula: C29H44ClN5O18P4. Mole weight: 910.033. | |
| Pyrotinib | Pyrotinib, also known as SHR-1258, is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. Synonyms: (R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide; Pyrotinib; SHR-1258; SHR1258; SHR 1258; Pyrotinib maleate. CAS No. 1269662-73-8. Molecular formula: C32H31ClN6O3. Mole weight: 582.21. | |
| Pyrrole-2,3,5-Tricarboxylic Acid | Pyrrole-2,3,5-tricarboxylic Acid is the most characteristic degrdadation product of melanins. It is an important biomarker for Melatonin metabolism. Synonyms: 1H-Pyrrole-2,3,5-tricarboxylic Acid. Grades: > 95%. CAS No. 945-32-4. Molecular formula: C7H5NO6. Mole weight: 199.12. | |
| Pyrvinium pamoate | Pyrvinium pamoate, a nonabsorbed anthelmintic drug, is a potent androgen receptor inhibitor and a selective WNT pathway inhibitor. Pyrvinium pamoate is a potential drug candidate for the treatment of cryptosporidiosis in both immunocompetent and immunocompromised individuals. Uses: Anthelmintics. Synonyms: VPC-14337; VPC 14337; VPC14337; 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium; Alnoxin; Altolat; NSC 223622; PP; Pamovin; Vermitibier; Vipyrvinium embonate. CAS No. 3546-41-6. Molecular formula: C26H28N3.1/2C23H14O6. Mole weight: 575.7. | |
| Q203 | Q203, also known as IAP6, was active against the reference strain M. tuberculosis H37Rv at a minimum concentration required to inhibit the growth of 50% of organisms (MIC50) of 2.7 nM in culture broth medium and at a MIC50 of 0.28 nM inside macrophages. Synonyms: Q203; Q 203; Q-203; 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide; 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide. CAS No. 1334719-95-7. Molecular formula: C29H28ClF3N4O2. Mole weight: 557.01. | |
| Quinine hemisulfate dihydrate | Quinine hemisulfate acts as a K+ channel blocker. Uses: Analgesics, non-narcotic. Synonyms: Quinine sulfate hydrate(2:1:4). Grades: >98%. CAS No. 6119-70-6. Molecular formula: C40H58N4O12S. Mole weight: 819. | |
| Quinolin-8-yl 2,2,5,5-Tetramethylthiazolidine-4-carboxylate | Quinolin-8-yl 2,2,5,5-Tetramethylthiazolidine-4-carboxylate is an intermediate in the synthesis of D-Penicillamine, which is a penicillin metabolite used in the treatment of Wilson's disease, Cystinuria, Scleroderma and arsenic poisoning. Molecular formula: C17H20N2O2S. Mole weight: 316.42. | |
| Quizartinib | This active molecular also known as AC220 and AC010220, is developed as a new second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, ten fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Now Quizartinib is in Phase-III clinical trials in Acute myeloid leukaemia. Uses: Treatment of acute myeloid leukaemia(aml). Synonyms: 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea; AC220; AC 220; AC-220; AC010220; AC-010220; AC 010220; AC010220; Quizartinib. Grades: 98%. CAS No. 950769-58-1. Molecular formula: C29H32N6O4S. Mole weight: 560.67. | |
| (R)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt | (R)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt is a metabolite of Carbamazepine, which is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. Synonyms: (10R)-5-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; (R)-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; R-Licarbazepine Glucuronide Sodium Salt. Grades: ≥95%. Molecular formula: C21H21N2NaO8. Mole weight: 452.39. | |
| (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole | (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 1370190-85-4. Molecular formula: C14H13F2N3O. Mole weight: 277.27. | |
| (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethanone | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity YX. Grades: ≥95%. CAS No. 1288338-95-3. Molecular formula: C24H24N6O2. Mole weight: 428.49. | |
| (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: (αR)-α-methyl-3,5-bis(trifluoromethyl)-Benzenemethanol; (+)-(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol. Grades: ≥95%. CAS No. 127852-28-2. Molecular formula: C10H8F6O. Mole weight: 258.16. | |
| R162 | R162 is a potent, selective inhibitor of glutamate dehydrogenase 1 (GDH1) (Ki = 28.6 μM), with anti-cancer properties. It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. Synonyms: R 162; R-162; 2-allyl-1-hydroxy-anthraquinone; 2-allyl-1-hydroxyanthra-9,10-quinone. CAS No. 64302-87-0. Molecular formula: C17H12O3. Mole weight: 264.28. | |
| (R)-1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic Acid | An isomer of Etodolac. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2. Uses: The r-enantiomer of etodolac (e933090). anti-inflammatory; analgesic. Synonyms: 2-[(1R)-1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl]acetic acid; 2-[(1R)-1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl]acetic acid. Grades: > 95 %. CAS No. 87226-41-3. Molecular formula: C17H21NO3. Mole weight: 287.35. | |
| (R)-1-Benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)pyridin-1-ium | (R)-1-Benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)pyridin-1-ium is an intermediate in the synthesis of Donepezil, which is a highly specific reversible acetylcholinesterase (AChE) inhibitor used to treat moderate to severe Alzheimer's disease. Synonyms: Donepezil impurity; (2R)-1-Benzyl-4-[(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl]pyridinium; Pyridinium, 4-[(2,3-dihydro-5,6-dimethoxy-1-oxo-1H-inden-2-yl)methyl]-1-(phenylmethyl)-, (R)-; (R)-1-Benzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-pyridinium. Molecular formula: C24H24NO3?. Mole weight: 374.45. | |
| (R)-1-((R)-1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 1-oxide | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity BZDYH. Grades: ≥95%. CAS No. 2031255-25-9. Molecular formula: C25H24N6O3. Mole weight: 456.51. | |
| (R)-2-(3-Phenyl-3-(o-tolyloxy)propyl)isoindoline-1,3-dione | (R)-2-(3-Phenyl-3-(o-tolyloxy)propyl)isoindoline-1,3-dione is an intermediate in the synthesis of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Molecular formula: C24H21NO3. Mole weight: 371.43. | |
| (R)-2-((6-(3-((3-(2-Cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile | An impurity of Trelagliptin. Trelagliptin is a pharmaceutical drug used for the treatment of type 2 diabetes. Synonyms: 4-Fluorobenzonitrile, (R)-2-((6-(3-((3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-; Trelagliptin Impurity I. Grades: 99%. CAS No. 1917324-13-0. Molecular formula: C31H32F2N8O4. Mole weight: 614.61. | |
| (R)-2-((6-(3-aminopiperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile | (R)-2-((6-(3-aminopiperidin-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile is an impurity of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in the class of oral antidiabetic drugs. Synonyms: UNII-625UXD6CJI; 865758-98-1; Alogliptin metabolite M-I; 625UXD6CJI; CHEMBL1650435; 2-[[6-[(3R)-3-aminopiperidin-1-yl]-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile; 2-((6-((3R)-3-Amino-1-piperidinyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl)benzonitrile; Alogliptin Impurity 13; Benzonitrile, 2-((6-((3R)-3-amino-1-piperidinyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl)-; SCHEMBL390872; KYXUNUKTHMZSLE-CQSZACIVSA-N; (R)-2-((6-(3-aminopiperidin-1-yl)-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; BDBM50335792; 2-{6-[3(R)-Aminopiperidin-1-yl]-2,4-dioxo-3,4-dihydro-2Hpyrimidin-1-ylmethyl}benzonitrile; 2-{6-[3(R)-Amino-piperidin-1-yl]-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl}-benzonitrile. CAS No. 865758-98-1. Molecular formula: C17H19N5O2. Mole weight: 325.36. | |
| (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzamide | An impurity of Trelagliptin. Trelagliptin is a pharmaceutical drug used for the treatment of type 2 diabetes. Synonyms: Benzamide, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-; Trelagliptin Impurity R. Grades: >95%. CAS No. 1938080-44-4. Molecular formula: C18H22FN5O3. Mole weight: 375.40. | |
| (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzoic acid | An impurity of Trelagliptin. Trelagliptin is a pharmaceutical drug used for the treatment of type 2 diabetes. Synonyms: Trelagliptin Impurity S. CAS No. 1917324-15-2. Molecular formula: C18H23FN4O4. Mole weight: 378.41. | |
| (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzamide | (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzamide is an impurity of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in the class of oral antidiabetic drugs. Synonyms: Alogliptin Impurity 14; Alogliptin Carbamoyl Impurity. CAS No. 1820685-30-0. Molecular formula: C18H23N5O3. Mole weight: 357.41. | |
| (R)-2-amino-5-(((R)-1-((carboxymethyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-5-oxopentanoic acid | One of the impurities of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Synonyms: Glycine, N-(N-D-γ-glutamyl-L-cysteinyl)-; Glutathione Impurity 08. CAS No. 108457-42-7. Molecular formula: C10H17N3O6S. Mole weight: 307.32. | |
| ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-58-0. Molecular formula: C20H23NO3. Mole weight: 325.408. | |
| (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid | Cas No. 51543-40-9. | |
| (R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl acrylate | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 2-Propenoic acid, 3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-3-oxopropyl ester; Ibrutinib Impurity BXSJC. Grades: ≥95%. CAS No. 2244619-11-0. Molecular formula: C28H28N6O4. Mole weight: 512.56. | |
| (R)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran | (R)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (3R)-3-[4-(5-Bromo-2-chlorobenzyl)phenoxy]tetrahydrofuran. CAS No. 915095-90-8. Molecular formula: C17H16BrClO2. Mole weight: 367.66. | |
| (R)-3-(4-Chlorophenyl)-4-hydroxybutyric Acid Sodium Salt | (R)-3-(4-Chlorophenyl)-4-hydroxybutyric Acid Sodium Salt is a metabolite of Baclofen, which is a specific GABA-B receptor agonist with muscle relaxant effect. Synonyms: Sodium (R)-3-(4-chlorophenyl)-4-hydroxybutanoate; (R)-4-Chloro-β-(hydroxymethyl)-benzenepropanoic Acid Sodium Salt; (R)-β-(p-Chlorophenyl)-γ-hydroxybutyric Acid Sodium Salt. Grades: 98%. CAS No. 1346617-22-8. Molecular formula: C10H10ClNaO3. Mole weight: 236.63. | |
| (R)-(3-(4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate | (R)-(3-(4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate is an impurity of Linezolid, an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant. Linezolid works by inhibiting bacterial protein synthesis. Synonyms: 2-Oxazolidinone, 5-[[(methylsulfonyl)oxy]methyl]-3-[4-(4-morpholinyl)phenyl]-, (5R)-; Linezolid Impurity 26. CAS No. 556801-09-3. Molecular formula: C15H20N2O6S. Mole weight: 356.39. | |
| (R)-4-((1-(3-(2-Cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)-4-oxobutanoic Acid | An impurity of Trelagliptin. Trelagliptin is a pharmaceutical drug used for the treatment of type 2 diabetes. Synonyms: 4-Oxobutanoic Acid, (R)-4-((1-(3-(2-cyano-5-fluorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)-; Trelagliptin Impurity 11. CAS No. 2087874-92-6. Molecular formula: C22H24FN5O5. Mole weight: 457.45. | |
| (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,Z)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,Z)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a] phenanthren-17-yl)pentanoic acid is an impurity of obeticholic acid, which is used in the treatment of primary biliary cholangitis and various liver diseases. Synonyms: (E)-3-hydroxy-6-ethylidene-7-keto-5-cholan-24-oic acid. CAS No. 1516887-34-5. Molecular formula: C26H40O4. Mole weight: 416.60. | |
| (R)-5-chloro-N-(4-(3-oxomorpholino)phenyl)-N-((2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide | An impurity of Rivaroxaban. Rivaroxaban inhibits both free Factor Xa and Factor Xa bound in the prothrombinase complex. It is a highly selective direct Factor Xa inhibitor with oral bioavailability and rapid onset of action. Synonyms: Rivaroxaban Impurity 26; 2-Thiophenecarboxamide, 5-chloro-N-[4-(3-oxo-4-morpholinyl)phenyl]-N-[[(5R)-2-oxo-5-oxazolidinyl]methyl]-. CAS No. 1879903-65-7. Molecular formula: C19H18ClN3O5S. Mole weight: 435.88. | |
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