BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Handle region peptide, rat acetate | Handle region peptide, rat acetate is a prorenin receptor antagonist. It suppresses the progression of diabetic nephropathy and has anti-inflammatory activities in the eye. Molecular formula: C56H105N15O14S. Mole weight: 1244.61. |  |
| Harmane-d4 | An isotope labelled of Harmane.Harmane is a heterocyclic amine found in a variety of foods including coffee. Grade: 95% by HPLC; 98% atom D. Molecular formula: C12H6D4N2. Mole weight: 186.25. | |
| Harman hydrochloride | Harman hydrochloride is an endogenous ligand for imidazoline binding sites. It binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Harmane also acts as a potent inhibitor of monoamine oxidase A and B (IC50 = 0.5 and 5 μM, respectively). Synonyms: 9H-Pyrido[3,4-b]indole, 1-methyl-, hydrochloride (1:1); 9H-Pyrido[3,4-b]indole, 1-methyl-, monohydrochloride; 1-Methyl-9H-pyrido[3,4-b]indole hydrochloride; Harman monohydrochloride; Harmane hydrochloride. Grade: 95%. CAS No. 21655-84-5. Molecular formula: C12H10N2.HCl. Mole weight: 218.68. | |
| Harmol | Harmol is an apoptosis inducer. Synonyms: 1-methyl-9H-pyrido[3,4-b]indol-7-ol; 1-Methyl-9H-beta-carbolin-7-ol. CAS No. 487-03-6. Molecular formula: C12H10N2O. Mole weight: 198.225. | |
| Harmol hydrochloride | Harmol is an apoptosis inducer. Synonyms: Harmol HCl; 1-methyl-2,9-dihydropyrido[3,4-b]indol-7-one hydrochloride. CAS No. 40580-83-4. Molecular formula: C12H11ClN2O. Mole weight: 234.683. | |
| HAT-IN-1 | HAT-IN-1 is an inhibitor of HAT, used in cancer research. Synonyms: 2-(5'-Bromo-2,3',5-trioxo-2',3'-dihydro-1H-spiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-[(2S)-1,1,1-trifluoro-2-propanyl]acetamide; Spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide, 5'-bromo-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-2,3',5-trioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-; 2-(5'-Bromo-2,3',5-trioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide. CAS No. 1889281-94-0. Molecular formula: C23H18BrF4N3O4. Mole weight: 556.30. | |
| HAT Inhibitor II | HAT Inhibitor II is a cell-permeable and selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 μM). It has been shown to decrease histone H3 acetylation (IC50 ≤ 40 μM) and induce chromatin condensation in HeLa cells. Synonyms: Histone Acetyltransferase Inhibitor II; (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one. Grade: ≥98%. CAS No. 932749-62-7. Molecular formula: C20H16Br2O3. Mole weight: 464.2. | |
| HBDDE | HBDDE is an Inhibitor of PKCα (IC50 = 43 μM) and PKCγ (IC50 = 50 μM). HBDDE induces neuronal apoptosis. Synonyms: 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether; [1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)-. Grade: 95%. CAS No. 154675-18-0. Molecular formula: C16H18O8. Mole weight: 338.31. | |
| HBF-0259 | HBF-0259 is a potent and selective hepatitis B virus (HBV) surface antigen (HBsAg) secretion inhibitor, with an EC50 of 1.5 μM in HepG2.2.15 cells. It has no effect on HBV DNA synthesis. Synonyms: Tetrazolo[1,5-a]pyrimidine, 7-(2-chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydro-; 7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine. Grade: ≥95%. CAS No. 957011-15-3. Molecular formula: C16H12Cl2FN5. Mole weight: 364.20. | |
| HBV-IN-10 | HBV-IN-10 is an enantiomer of compound 6 (WO2021204258A1), which is a hepatitis B surface antigen (HBsAg) inhibitor (0.001 μM< EC50 ≤0.05 μM). (Extracted from patent WO2021204258A1, compound 6). Synonyms: (5R,8S)-10-(6-fluoro-4-(3-methoxypyrrolidin-1-yl)pyridin-2-yl)-2-(pyrimidin-2-yl)-6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[d]pyrimidine. Grade: ≥98% (HPLC). CAS No. 2716907-16-1. Molecular formula: C23H24FN7O. Mole weight: 433.48. | |
| HBV-IN-11 | HBV-IN-11 is a potent inhibitor of HBsAg secretion with an EC50 of 0.46 μM. (Extracted from patent WO2018085619A1, example 28). Synonyms: (S)-2-chloro-7-isopropyl-3-(3-methoxypropoxy)-11-oxo-6,7-dihydro-11H-benzo[f]pyrido[1,2-d][1,4]oxazepine-10-carboxylic acid. Grade: ≥98% (HPLC). CAS No. 2226178-41-0. Molecular formula: C21H24ClNO6. Mole weight: 421.87. | |
| HBV-IN-12 | HBV-IN-12 is a potent inhibitor of hepatitis B surface antigen (HBsAg) (0.001 μM< EC50 ≤0.05 μM). It has anti-HBV DNA activity (0.001 μM| | |
| HBV-IN-13 | HBV-IN-13 is a potent inhibitor of hepatitis B surface antigen (HBsAg). (Extracted from patent WO2021204252A1, compound 1_B). Synonyms: (S)-7-isopropyl-4-(3-methoxypropoxy)-11-oxo-6,11-dihydro-7H-[1,3]dioxolo[4,5-h]pyrido[2,1-a]isoquinoline-10-carboxylic acid. Grade: ≥98% (HPLC). CAS No. 2724228-72-0. Molecular formula: C22H25NO7. Mole weight: 415.44. | |
| HBV-IN-4 | HBV-IN-4, a potent and orally active inhibitor of HBV DNA replication (IC50 = 14 nM), induces the formation of genome-free capsids and has potent anti-HBV effect. Synonyms: Benzonitrile, 4-[[4-[5-chloro-6-[(2,3-dihydroxypropyl)amino]-2-fluoro-3-pyridinyl]-1-oxo-2(1H)-phthalazinyl]methyl]-. Grade: ≥95%. CAS No. 2305897-84-9. Molecular formula: C24H19ClFN5O3. Mole weight: 479.89. | |
| HBV-IN-6 | HBV-IN-6 is a potent inhibitor of HBV with an EC50 of 44 nM. (Extracted from patent WO2021213445A1, compound 3). Synonyms: 2-(4-(5-((3R,5S)-5-((3-chloro-4-fluorophenyl)carbamoyl)-6-methyl-1,1-dioxido-1,2,6-thiadiazinan-3-yl)thiophen-2-yl)phenyl)acetic acid. Grade: ≥98% (HPLC). CAS No. 2724224-47-7. Molecular formula: C23H21ClFN3O5S2. Mole weight: 538.01. | |
| HBV-IN-7 | HBV-IN-7 is a potent inhibitor of HBV with an EC50 of 7 nM. (Extracted from patent WO2021213445A1, compound 5). Synonyms: (E)-3-(5-(5-((3-chloro-4-fluorophenyl)carbamoyl)-6-methyl-1,1-dioxido-1,2,6-thiadiazinan-3-yl)thiophen-2-yl)acrylic acid. Grade: ≥98% (HPLC). CAS No. 2724224-49-9. Molecular formula: C18H17ClFN3O5S2. Mole weight: 473.93. | |
| HBV-IN-8 | HBV-IN-8 is a potent inhibitor of HBV with an EC50 of 287.9 nM. (Extracted from patent WO2021213445A1, compound 13). Synonyms: 4-Piperidineacetic acid, 1-[5-[5-[[(3-chloro-4-fluorophenyl)amino]carbonyl]tetrahydro-6-methyl-1,1-dioxido-2H-1,2,6-thiadiazin-3-yl]-2-thiazolyl]-. Grade: ≥98% (HPLC). CAS No. 2724224-57-9. Molecular formula: C21H25ClFN5O5S2. Mole weight: 546.04. | |
| HBV-IN-9 | HBV-IN-9, a potent HBsAg (HBV Surface antigen) inhibitor (IC50 = 10 nM), is an HBV DNA production inhibitor with an IC50 of 0.15 nM in HepG2.2.15 cells. (Extracted from patent WO2018001952A1, example 20). Synonyms: Pyrido[4,3-d]pyrimidine, 6-[6-fluoro-4-(3-methoxy-1-pyrrolidinyl)-2-pyridinyl]-5,6,7,8-tetrahydro-5-methyl-2-(2-pyrimidinyl)-. Grade: ≥98% (HPLC). CAS No. 2170998-69-1. Molecular formula: C22H24FN7O. Mole weight: 421.47. | |
| HBX 19818 | HBX 19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3, showing this compound's specificity for USP7 over a panel of active DUBs under physiological conditions proved to be active in cells, as it almost completely inhibited USP7 labeling at 25 mM. MS/MS spectrum revealed that HBX 19,818 is attached to Cys315. Based on UV chromatogram (l = 332 nm) peak areas, HBX 19,818 partially reverses the deubiquitination of Mdm2 by USP7 in HEK293 cells, confirming that HBX 19,818 inhibits a biological activity of USP7 in living cells. HBX 19,818 has additional off-target, p53-independent proapoptotic effects. Synonyms: HBX19818; HBX-19818. Grade: >98%. CAS No. 1426944-49-1. Molecular formula: C25H28ClN3O. Mole weight: 421.96. | |
| HBX 41108 | HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 424 nM). HBX 41108 inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). HBX 41108 stabilizes p53, activates transcription of a p53 target gene without inducing genotoxic stress, and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines. Synonyms: HBX 41108; HBX-41108; HBX41108; HBX 41,108; HBX-41,108; HBX41,108. 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile. Grade: ≥98% by HPLC. CAS No. 924296-39-9. Molecular formula: C13H3ClN4O. Mole weight: 266.64. | |
| HC-030031 | HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. Synonyms: HC-030031; HC 030031; HC030031. TOSLAB 829227. Grade: >98%. CAS No. 349085-38-7. Molecular formula: C18H21N5O3. Mole weight: 355.39. | |
| HC-067047 | HC-067047 is a potent and selective TRPV4 antagonist. It has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis. HC-067047 also attenuated allodynia in diabetic mice, suggesting its potential application for the treatment of painful diabetic neuropathy (PDN). Synonyms: HC 067047; HC067047; 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide. Grade: ≥98%. CAS No. 883031-03-6. Molecular formula: C26H28F3N3O2. Mole weight: 471.5. | |
| HC 067047 hydrochloride | HC-067047 is a potent and selective TRPV4 antagonist. It has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis. HC-067047 also attenuated allodynia in diabetic mice, suggesting its potential application for the treatment of painful diabetic neuropathy (PDN). Synonyms: 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide hydrochloride. CAS No. 1481646-76-7. Molecular formula: C26H29ClF3N3O2. Mole weight: 507.98. | |
| hCAII-IN-8 | hCAII-IN-8 is a potent and selective inhibitor of carbonic anhydrase (CA). Synonyms: Compound CDy9. CAS No. 952306-80-8. Molecular formula: C15H16N2O5S. Mole weight: 336.4. | |
| hCAIX-IN-5 | hCAIX-IN-5 is a Carbonic anhydrase IX (hCAIX) inhibitor. Synonyms: TS-09247. Grade: 98% by HPLC. CAS No. 2451479-57-3. Molecular formula: C18H12FNO3. Mole weight: 309.3. | |
| HCH6-1 | HCH6-1 is a dipeptide antagonist of formyl peptide receptor 1 (FPR1). HCH6-1 has the potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases. Synonyms: Methyl benzoyl-L-tryptophyl-D-phenylalaninate. CAS No. 1435265-06-7. Molecular formula: C28H27N3O4. Mole weight: 469.53. | |
| Hck-IN-1 | Hck-IN-1 is a selective inhibitor of Nef-dependent Hck with IC50s of 2.8 and >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide antagonist of HIV-1 Nef with an IC50 of 100-300 nM for wild-type HIV-1 replication. It binds pocket residue Asn126 and has anti-retroviral activity. Synonyms: Nef-IN-B9; (E)-4-((3-Chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide; 1H-Pyrazole-1-carbothioamide, 4-[(1E)-2-(3-chlorophenyl)diazenyl]-5-hydroxy-3-(4-nitrophenyl)-. Grade: ≥98%. CAS No. 1473404-51-1. Molecular formula: C16H11ClN6O3S. Mole weight: 402.81. | |
| HCoV-229E-IN-1 | HCoV-229E-IN-1 is a potent HCoV-229E replication inhibitor, with an EC50 value of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively. Synonyms: HCoV-229E-IN-1|CHEMBL4854936|HY-132169|CS-0163711. Grade: 99%. Molecular formula: C38H53N3O2. Mole weight: 583.85. | |
| HCV371 | HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectivity and lack of cytotoxicity in the antiviral assays. It displayed broad inhibitory activities against the NS5B RdRp enzyme. It showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma and other unrelated viral polymerases. Synonyms: HCV-371; HCV 371; HCV371. (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid. Grade: 98%. CAS No. 675184-27-7. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
| HCV-IN-29 | HCV-IN-29 is an inhibitor of hepatitis C virus (HCV). (Exacted from patent US8329159B2, compound 1e). Synonyms: 4,4'-Bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,1'-biphenyl tetrahydrochloride; 5,5'-[1,1'-Biphenyl]-4,4'-diylbis[2-(2S)-2-pyrrolidinyl-1H-imidazole] Hydrochloride; 5,5'-(4,4'-Biphenyldiyl)bis{2-[(2S)-2-pyrrolidinyl]-1H-imidazole} tetrahydrochloride. Grade: ≥98% (HPLC). CAS No. 1009119-83-8. Molecular formula: C26H32Cl4N6. Mole weight: 570.38. | |
| HCV-IN-3 | HCV-IN-3 is an inhibitor of hepatitis C virus (HCV) NS3/4a protein, with an IC50 of 20 μM and a Kd of 29 μM. Synonyms: 2,4-Difluoro-3-phenoxybenzenemethaneamine; Benzenemethanamine, 2,4-difluoro-3-phenoxy-; 1-(2,4-Difluoro-3-phenoxyphenyl)methanamine. Grade: ≥95%. CAS No. 1401839-25-5. Molecular formula: C13H11F2NO. Mole weight: 235.23. | |
| HCV-IN-30 | HCV-IN-30 is an inhibitor of HCV NS5A replication complex with IC50s of 901 and 102 nM against genotypes 1a and 1b replicons, respectively. Synonyms: (2S,2'S)-Di-tert-butyl 2,2'-(5,5'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate); Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate); (2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis-1-pyrrolidinecarboxylic acid 1,1'-bis(1,1-dimethylethyl) ester; 1-Pyrrolidinecarboxylic acid, 2,2'-([1,1'-biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis-, 1,1'-bis(1,1-dimethylethyl) ester, (2S,2'S)-. Grade: ≥98% (HPLC). CAS No. 1007882-23-6. Molecular formula: C36H44N6O4. Mole weight: 624.77. | |
| HCV-IN-31 | HCV-IN-31 is an inhibitor of HCV, with an EC50/EC95 of 15.7 μM for HCV replicon. Synonyms: (2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol; Adenosine, 2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-, (2'R)-; 2-Amino-2'-deoxy-2'-fluoro-N,2'-dimethyladenosine. Grade: ≥95%. CAS No. 1998705-62-6. Molecular formula: C12H17FN6O3. Mole weight: 312.30. | |
| HCV-IN-4 | HCV-IN-4 is a potent and orally bioactive HCV NS5A inhibitor, displaying great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC90s values of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively. Synonyms: HCV-IN-4|CHEMBL3980210|HY-P0162|CS-0020242. Grade: ≥98% (HPLC). CAS No. 2058080-25-2. Molecular formula: C52H58FN9O8. Mole weight: 956.07. | |
| HCV-IN-7 | HCV-IN-7, a potent and orally active pan-genotypic HCV NS5A inhibitor (IC50 of 3-47 pM) with antiviral activity, demonstrates superior pan-genotypic profile and good pharmacokinetic characteristics, as well as favorable liver uptake. Synonyms: Methyl [(2S)-1-{(2S)-2-[5-(2-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-5-yl}naphtho[1,2-b]thiophen-7-yl)-1H-imidazol-2-yl]-1-pyrrolidinyl}-3-methyl-1-oxo-2-butanyl]carbamate; Carbamic acid, N,N'-[naphtho[1,2-b]thiene-2,7-diylbis[1H-imidazole-5,2-diyl(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, dimethyl ester. Grade: ≥95%. CAS No. 1449756-86-8. Molecular formula: C40H48N8O6S. Mole weight: 768.92. | |
| HCV-IN-7 dihydrochloride | HCV-IN-7 hydrochloride, a potent and orally active pan-genotypic HCV NS5A inhibitor (IC50 of 3-47 pM) with antiviral activity, demonstrates superior pan-genotypic profile and good pharmacokinetic characteristics, as well as favorable liver uptake. Synonyms: Methyl [(2S)-1-{(2S)-2-[5-(2-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-5-yl}naphtho[1,2-b]thiophen-7-yl)-1H-imidazol-2-yl]-1-pyrrolidinyl}-3-methyl-1-oxo-2-butanyl]carbamate dihydrochloride; Carbamic acid, N,N'-[naphtho[1,2-b]thiene-2,7-diylbis[1H-imidazole-5,2-diyl(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, dimethyl ester, hydrochloride (1:2). Grade: ≥95%. CAS No. 1449756-87-9. Molecular formula: C40H50Cl2N8O6S. Mole weight: 841.85. | |
| HCVP-IN-1 | HCVP-IN-1 is an inhibitor of hepatitis C viral polymerase (HCVP). Synonyms: Pf-868554; 2-[4-(2-{(2R)-2-Cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)-2-fluorophenyl]-2-methylpropanenitrile; Benzeneacetonitrile, 4-[2-[(2R)-2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-3,6-dihydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-2-fluoro-α,α-dimethyl-; (R)-2-(4-(2-(2-cyclopentyl-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-2-fluorophenyl)-2-methylpropanenitrile. Grade: 95%. CAS No. 877225-09-7. Molecular formula: C30H34FN5O3. Mole weight: 531.62. | |
| H-D-3-Pal-OH 2HCl | H-D-3-Pal-OH 2HCl, a synthetic peptide of scientific interest, has the potential to be a promising avenue in the pursuit of new treatments for diseases of varying kinds. Research into the properties of this compound suggests its ability to inhibit cell proliferation and promote apoptosis in oncogenic cells. Interestingly, it may also function as an immunomodulator and possess therapeutic applications towards autoimmune disorders. These findings speak to the complex and multifaceted nature of H-D-3-Pal-OH 2HCl and the implications it could have in furthering scientific understanding of these conditions. Synonyms: (R)-2-Amino-3-(pyridin-3-yl)propanoic acid dihydrochloride; H-D-3-Pal-OH.2HCl; 3-(3-Pyridyl)-D-alanine dihydrochloride. Grade: 95%. CAS No. 93960-21-5. Molecular formula: C8H12Cl2N2O2. Mole weight: 239.10. | |
| HDAC1/2-IN-3 | HDAC1/2-IN-3 is an inhibitor of HDAC1 and HDAC2 with IC50s of 0-5 and 5-10 nM, respectively. Synonyms: N-(2-amino-5-(thiophen-2-yl)phenyl)-7-((2-(dimethylamino)ethyl)amino)-3-isoquinolinecarboxamide. CAS No. 2121516-17-2. Molecular formula: C24H25N5OS. Mole weight: 431.55. | |
| HDAC3 Inhibitor | HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM, IC50s = 0.95 nM). HDAC3 inhibitors increase histone acetylation and restore normal transcriptional patterns. Treatment with inhibitors primarily targeting HDAC3, including some with additional activity on HDAC1, led to improvement in motor function and working memory in N-terminal transgenic HD mice. Synonyms: Histone Deacetylase 3 Inhibitor; (E)-3-Phenyl-N-[[4-(propylaminocarbamoyl)phenyl]methyl]prop-2-enamide. Grade: ≥98%. CAS No. 2044701-99-5. Molecular formula: C20H23N3O2. Mole weight: 337.4. | |
| HDAC6-IN-3 | HDAC6-IN-3 is an antiprostate cancer drug that is an effective MAO-A (IC50 = 0.79 μM) and LSD1 inhibitor, and a potent and orally active HDAC6 inhibitor with IC50s ranging from 0.02 to 1.54 μM for HDAC1/2/3/6/8/10. Synonyms: N1-hydroxy-N8-(3-((methyl(prop-2-yn-1-yl)amino)methyl)phenyl)octanediamide. Molecular formula: C19H27N3O3. Mole weight: 345.44. | |
| HDAC8-IN-1 | HDAC8-IN-1 is a HDAC8 inhibitor with IC50 of 27.2 nM in cancer cell lines. Synonyms: (E)-N-hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide; VC-7933. Grade: 98% by HPLC. CAS No. 1417997-93-3. Molecular formula: C22H19NO3. Mole weight: 345.4. | |
| HDAC/BET-IN-1 | HDAC/BET-IN-1 shows submicromolar inhibitory activity against HDAC1 and 6 (IC50s = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM). It has potent antileukemia activity. Synonyms: N-(2-((8-(hydroxyamino)-8-oxooctyl)oxy)-5-(morpholinosulfonyl)phenyl)-3-methyl-4-oxo-2,4,5,6,7,8-hexahydrocyclohepta[c]pyrrole-1-carboxamide. Molecular formula: C29H40N4O8S. Mole weight: 604.71. | |
| HDAC-IN-1 | HDAC-IN-1, an analogue of MC 1568, is a Iia HDACs inhibitor that could probably influence myogenesis and adipogenesis. Uses: Hdac-in-1 is a iia hdacs inhibitor that could probably influence myogenesis and adipogenesis. Synonyms: MC1568; MC 1568; MC-1568; HDAC-IN-1; HDAC IN 1. Grade: 98%. CAS No. 1239610-44-6. Molecular formula: C17H15FN2O3. Mole weight: 314.31. | |
| HDAC-IN-2 | HDAC-IN-2, a selective HDAC inhibitor, has been found to probably restrain the transcription and division of tumor oncogene and could also lead to the apoptosis of tumor cells.It is under Phase II trials against Multiple myeloma. IC50: 4 nM and 76 nM for. Uses: Hdac-in-2 is a selective hdac inhibitor that has been found to probably restrain the transcription and division of tumor oncogene and could also lead to the apoptosis of tumor cells.it is under phase ii trials against multiple myeloma. Synonyms: ACY-241; ACY 241; ACY241; HDAC-IN-2; Citarinostat; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat. Grade: 98%. CAS No. 1316215-12-9. Molecular formula: C24H26ClN5O3. Mole weight: 467.95. | |
| HDAC-IN-26 | HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC50 of 4.7 nM. Synonyms: (S)-N-(1-(5-(2-fluorophenyl)-1H-imidazol-2-yl)-7-(isoxazol-3-yl)-7-oxoheptyl)-1-methylazetidine-3-carboxamide; N-[(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]-7-isoxazol-3-yl-7-oxo-heptyl]-1-methyl-azetidine-3-carboxamide. CAS No. 2410542-97-9. Molecular formula: C24H28FN5O3. Mole weight: 453.51. | |
| HDAC-IN-28 | HDAC-IN-28 is an inhibitor of HDAC that has potent activity against tumor growth and metastasis. Synonyms: N-(4-Methoxyphenyl)-N-[[5-(5-pyrimidinyl)-2-thienyl]methyl]-7-(hydroxyamino)-7-oxoheptanamide. CAS No. 1621154-88-8. Molecular formula: C23H26N4O4S. Mole weight: 454.54. | |
| HDAC-IN-32 | HDAC-IN-32 is a potent inhibitor of HDAC with IC50s of 5.2, 11 and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 has potent antiproliferation activities against tumor cells. It exhibits strong antitumor efficacy in vivo, and induces anti-tumor immunity. Synonyms: 7-(3-(1H-benzo[d]imidazol-2-yl)phenoxy)-N-hydroxyheptanamide. Molecular formula: C20H23N3O3. Mole weight: 353.41. | |
| HDAC-IN-33 | HDAC-IN-33 is a potent inhibitor of HDAC with IC50s of 24, 46 and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 has potent antiproliferation activities against tumor cells. It exhibits strong antitumor efficacy in vivo, and induces anti-tumor immunity. Synonyms: 8-(3-(1H-benzo[d]imidazol-2-yl)phenoxy)-N-hydroxyoctanamide. Molecular formula: C21H25N3O3. Mole weight: 367.44. | |
| HDAC-IN-5 | HDAC-IN-5 is an inhibitor of histone deacetylase (HDAC). Synonyms: N-((1-Methyl-4-(4-phenylthiazol-2-yl)piperidin-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; Benzamide, N-[[1-methyl-4-(4-phenyl-2-thiazolyl)-4-piperidinyl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-; NU7. Grade: ≥95%. CAS No. 1314890-51-1. Molecular formula: C26H24F3N5O2S. Mole weight: 527.56. | |
| HDACs/mTOR Inhibitor 1 | HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. Grade: 98%. CAS No. 2271413-06-8. Molecular formula: C28H38N8O5. Mole weight: 566.65. | |
| hDHODH-IN-1 | hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory effect. Synonyms: (2Z)-N-Biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide; (2Z)-N-(4-Biphenylyl)-2-cyano-3-hydroxy-2-butenamide; 2-Butenamide, N-[1,1'-biphenyl]-4-yl-2-cyano-3-hydroxy-, (2Z)-; (2Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamide. Grade: ≥95%. CAS No. 1173715-42-8. Molecular formula: C17H14N2O2. Mole weight: 278.31. | |
| hDHODH-IN-2 | hDHODH-IN-2, an analogue of the active metabolite of Leflunomide, is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with anti-inflammatory activity. Synonyms: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide; (2Z)-N-(4-Biphenylyl)-2-cyano-3-cyclopropyl-3-hydroxyacrylamide; 2-Propenamide, N-[1,1'-biphenyl]-4-yl-2-cyano-3-cyclopropyl-3-hydroxy-, (2Z)-; (Z)-N-Biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide; (Z)-N-([1,1'-biphenyl]-4-yl)-2-cyano-3-cyclopropyl-3-hydroxyacrylamide. Grade: ≥95%. CAS No. 183946-00-1. Molecular formula: C19H16N2O2. Mole weight: 304.34. | |
| hDHODH-IN-3 | hDHODH-IN-3, a human dihydroorotate dehydrogenase inhibitor, inhibits measles virus replication with a pMIC50 of 8.6. Synonyms: DHODH-IN-2; 2-[4-(2-Bromophenoxy)-3-ethoxy-5-methyl-1H-pyrazol-1-yl]-5-ethylpyrimidine; Pyrimidine, 2-[4-(2-bromophenoxy)-3-ethoxy-5-methyl-1H-pyrazol-1-yl]-5-ethyl-. Grade: ≥95%. CAS No. 1644156-80-8. Molecular formula: C18H19BrN4O2. Mole weight: 403.27. | |
| hDHODH-IN-4 | hDHODH-IN-4 is a potent inhibitor of human dihydroorotate dehydrogenase (DHODH), with a pIC50 of 7.8 for human recombinant DHODH. It inhibits measles virus replication, with a pMIC50 of 8.8. Synonyms: [1-(5-Cyclopropyl-2-pyrimidinyl)-3-isopropoxy-5-methyl-1H-pyrazol-4-yl](phenyl)methanol; 1H-Pyrazole-4-methanol, 1-(5-cyclopropyl-2-pyrimidinyl)-5-methyl-3-(1-methylethoxy)-α-phenyl-; DHODH-IN-5. Grade: ≥95%. CAS No. 1644156-56-8. Molecular formula: C21H24N4O2. Mole weight: 364.44. | |
| hDHODH-IN-5 | DHODH-IN-7, a human dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = 0.91 μM), induces differentiation in acute myeloid leukemia. Synonyms: N-{3-Oxo-3-[(1R)-1,2,3,4-tetrahydro-1-naphthalenylamino]propyl}-4-(trifluoromethyl)benzamide; Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethyl)-; N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-3-{[4-(trifluoromethyl)phenyl]formamido}propanamide. Grade: ≥95%. CAS No. 2029049-77-0. Molecular formula: C21H21F3N2O2. Mole weight: 390.40. | |
| HDL376 | HDL376 is a scavenger receptor BI inhibitor. Synonyms: N-(5-Chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea; 1-(5-Chloro-2-methylphenyl)-3-isobutylthiourea; Thiourea, N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)-; SDZ-HDL 376; HDL 376; HDL-376. Grade: ≥95%. CAS No. 147751-31-3. Molecular formula: C12H17ClN2S. Mole weight: 256.79. | |
| H-D-Leu-Thr-Arg-PNA | H-D-Leu-Thr-Arg-PNA. Synonyms: ACMC-20mq5f. Grade: 95%. CAS No. 122630-72-2. Molecular formula: C22H36N8O6. Mole weight: 508.6. | |
| HDMAPP triammonium salt | HDMAPP is a photo-crosslinkable biotin derivative that targets the HMBPP Site of BTN3A1, and activates Vγ9Vδ2 T cells, which plays a key role in the cross talk of the innate and adaptive immune system. Synonyms: HMBPP triammonium; [[(E)-4-hydroxy-3-methylbut-2-enoxy]-oxidophosphoryl] phosphate triammonium salt. Grade: ≥90%. CAS No. 443892-56-6. Molecular formula: C5H9O8P2ยท3NH4. Mole weight: 313.2. | |
| H-D-Phe-Pro-arginal | H-D-Phe-Pro-arginal is a thrombin inhibitor which is being developed by IVAX for the potential treatment of thromboembolic disorders. It has a similar efficacy to heparin at the highest dose studied. Uses: H-d-phe-pro-arginal is developed for the potential treatment of thromboembolic disorders. Synonyms: GYKI-14166; GYKI14166; RGH-2958; GYKI 14166; RGH 2958; RGH2958; LY-294468; LY294468; Efegatran; (S)-1-(D-phenylalanyl)-N-((S)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide. Grade: 98%. CAS No. 60503-05-1. Molecular formula: C20H30N6O3. Mole weight: 402.57. | |
| HDS 029 | HDS 029 is a potent inhibitor of the ErbB receptor family including EGFR, ErbB2 and ErbB4 (IC50 = 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2, respectively). HDS 029 inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 = 2.5 and 24 nM, respectively). Synonyms: HDS 029; HDS 029; HDS 029; N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide; EGFR/ErbB-2/ErbB-4 Inhibitor. Grade: ≥97% by HPLC. CAS No. 881001-19-0. Molecular formula: C17H11ClFN5O. Mole weight: 355.76. | |
| HDTMP | HDTMP can inhibit most scale formations such as calcium carbonate, calcium sulfate, barium sulfate, and ferric oxide. However, in the water treatment industry, HMDTMPA is mainly used as a scale inhibitor for calcium sulfate and barium sulfate. Synonyms: Phosphonic acid, P,P',P'',P'''-[1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-; P,P',P'',P'''-[1,6-Hexanediylbis[nitrilobis(methylene)]]tetrakis[phosphonic acid]; Phosphonic acid, [1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-; Phosphonic acid, [hexamethylenebis(nitrilodimethylene)]tetra-; (Hexamethylenedinitrilo)tetrakis[methylenephosphonic acid]; 1,6-Hexanediaminetetrakis(methylene phosphonic acid); Briquest 462; Dequest 2051; HMDTMPA; HDTMPA; Hexamethylenedinitrilotetrakis(methylphosphonic acid); Hexanediaminetetra(methylenephosphonic acid); N,N,N',N'-1,6-Hexamethylenediaminetetrakis(methylenephosphonic acid); N,N,N',N'-Hexamethylenediaminetetra(methylenephosphonic acid). Grade: 95%. CAS No. 23605-74-5. Molecular formula: C10H28N2O12P4. Mole weight: 492.23. | |
| HDTMP hexapotassium salt | HDTMP hexapotassium salt is a good calcium sulfate scale inhibitor, which is suitable for high pH value and high alkaline environments. Synonyms: Phosphonic acid, P,P',P'',P'''-[1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-, potassium salt (1:6); Phosphonic acid, [1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-, hexapotassium salt; DQ 2054; Hexamethylenediaminetetra(methylenephosphonic acid), hexapotassium salt; K 6; Mayoquest 1635. CAS No. 53473-28-2. Molecular formula: C10H22K6N2O12P4. Mole weight: 720.77. | |
| HDTMP potassium salt | HDTMP potassium salt is a good calcium sulfate scale inhibitor, which is suitable for high pH value and high alkaline environments. Synonyms: Phosphonic acid, P,P'-[1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-, potassium salt (1:x); Phosphonic acid, [1,6-hexanediylbis[nitrilobis(methylene)]]tetrakis-, potassium salt; Dequest 2054; Hexamethylenediaminetetra(methylenephosphonic acid) potassium salt; N,N,N',N'-Tetrakis(phosphonomethyl)hexamethylenediamine potassium salt. CAS No. 38820-59-6. Molecular formula: C10H28N2O12P4.xK. Mole weight: 492.23 (free acid). | |
| HE-3235 | HE3235 is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. Synonyms: HE 3235; HE3235; Apoptone; (17R)-5alpha-Pregnane-20-yne-3alpha,17-diol. CAS No. 183387-50-0. Molecular formula: C21H32O2. Mole weight: 316.48. | |
| HEAT hydrochloride | HEAT hydrochloride is a selective α1-adrenoceptor antagonist, precursor to the 3-[125I]-derivative. Synonyms: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride; BE 2254; BE2254; BE-2254. Grade: ≥98% by HPLC. CAS No. 30007-39-7. Molecular formula: C19H21NO2.HCl. Mole weight: 331.84. | |
| Heat Shock Protein Inhibitor II | Heat shock protein (HSP) inhibitor II is the active metabolite of Hsp inhibitor I and suppresses the synthesis of inducible HSPs, such as HSP105, HSP72, and HSP40. Synonyms: HSP Inhibitor II; KNK 423; (3E)-3-(1,3-benzodioxol-5-ylmethylidene)pyrrolidin-2-one. Grade: ≥98%. CAS No. 1859-42-3. Molecular formula: C12H11NO3. Mole weight: 217.2. | |
| Heclin | Heclin is an HECT E3 ubiquitin ligase inhibitor. It also inhibits Nedd4, Smurf2 and WWP1 (IC50 = 6.3, 6.8 and 6.9 μM, respectively). Uses: Enzyme inhibitors. Synonyms: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide. Grade: ≥98% by HPLC. CAS No. 890605-54-6. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
| HeE1-2Tyr | HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses, which significantly inhibit SARS-CoV-2 RdRp. Synonyms: EX-A5472; N-[8-(Cyclohexyloxy)-1-Oxo-2-Phenyl-1h-Pyrido[2,1-B][1,3]benzothiazole-4-Carbonyl]-L-Tyrosine. Grade: 98%. CAS No. 2245195-67-7. Molecular formula: C33H30N2O6S. Mole weight: 582.67. | |
| Heliosupine | Heliosupine is an azabicycloalkane compound having angelyloxy and echimidinyloxymethyl substituents attached to the ring system. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 of 0.57 mM. Synonyms: Cynoglossofin; Cynoglossophine; 7-Angelyl-9-echimidinylheliotridine; 2-Methyl-2-butenoic acid 7-[[2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobutoxy)methyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl. CAS No. 32728-78-2. Molecular formula: C20H31NO7. Mole weight: 397.46. | |
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