BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Norepinephrine Tartrate Impurity 1 | An impurity of Norepinephrine, which is an antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Uses: Sympathomimetics. Synonyms: (R)-[R-(R*,R*)]-2,3-Dihydroxybutanedioate 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; (2R,3R)-2,3-Dihydroxybutanedioate 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Arterenol Tartrate (-)-α-(Aminomethyl)-3,4-dihydroxy-benzyl Alcohol Tartrate. Grades: > 95%. CAS No. 51-40-1. Molecular formula: C8H11NO3. C4H6O6. Mole weight: 169.18 150.09. |  |
| Norepinephrine Tartrate Impurity 2 | Norepinephrine Sulfonic Acid is a derivative of Norepinephrine. Norepinephrine, also known as noradrenaline, is a marker for catecholamine-secreting tumors such as pheochromocytoma, paraganglioma, and neuroblastoma. Synonyms: Norepinephrine Sulfonic Acid; α-(Aminomethyl)?-3,?4-dihydroxy-benzenemethanesulfon?ic Acid. Grades: > 95%. CAS No. 24159-36-2. Molecular formula: C8H11NO5S. Mole weight: 233.24. | |
| Norepinephrine Tartrate Impurity 3 | Norepinephrine Sulfonic Acid is a derivative of Norepinephrine. Norepinephrine, also known as noradrenaline, is a marker for catecholamine-secreting tumors such as pheochromocytoma, paraganglioma, and neuroblastoma. Synonyms: This is a controlled substance:Next for Status. Grades: > 95%. CAS No. 35538-87-5. Molecular formula: C8H11NO6S. Mole weight: 249.24. | |
| Norepinephrine Tartrate Impurity D | Cas No. 1932110-67-2. | |
| Norepinephrine Tartrate Impurity G | Cas No. 13062-58-3. | |
| Norepinephrine Tartrate (Noradrenaline Tartrate) | A derivative of Epinephrine. Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors. Synonyms: Noradrenaline Tartrate; 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, 2,3-dihydroxybutanedioate. Grades: > 95%. CAS No. 339091-66-6. Molecular formula: C8H11NO3. C4H6O6. Mole weight: 319.26. | |
| Norethindrone 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester | Norethindrone 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is a metabolite of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: Methyl (17α)-3-oxo-19-norpregn-4-en-20-yn-17-yl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate; Estr-4-en-3-one, 17-ethynyl-17-[(2,3,4-tri-O-acetyl-6-methyl-β-D-glucopyranuronosyl)oxy]-, (17β)-. Molecular formula: C33H42O11. Mole weight: 614.68. | |
| Norethindrone Acetate 3-Ethyl Ether | Norethindrone Acetate 3-Ethyl Ether is a derivative of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: 3-Ethoxy-19-nor-17α-pregna-3,5-dien-20-yn-17-ol Acetate; Norethindrone Impurity 3; Norethindrone Acetate EP Impurity I; 19-Norpregna-3,5-dien-20-yn-17-ol, 3-ethoxy-, acetate, (17α)-; Norethindrone Acetate Impurity 9. Grades: ≥95%. CAS No. 50717-99-2. Molecular formula: C24H32O3. Mole weight: 368.51. | |
| Norethindrone Impurity (17á-3-Ethynyl-19-Norpregna-3,5-Dien-20-yn-17-ol) | A derivative of Estradiol. Estradiol? is the major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female genotype in embryogenesis and at puberty. Synonyms: (17α)-3-Ethynyl-19-norpregna-3,5-dien-20-yn-17-ol. Grades: > 95%. CAS No. 79727-03-0. Molecular formula: C22H26O. Mole weight: 306.45. | |
| Norethindrone Sulfate Sodium Salt | Norethindrone Sulfate Sodium Salt is a metabolite of Norethindrone, which is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases. Synonyms: sodium (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl sulfate; (17α)-17-(Sulfooxy)-19-norpregn-4-en-20-yn-3-one Sodium Salt; 17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one Hydrogen Sulfate Sodium Salt. Grades: 95%. Molecular formula: C20H25NaO5S. Mole weight: 400.46. | |
| Norfluoxetine HCl | Norfluoxetine HCl is a N-desmethyl metabolite of fluoxetine which acts as a selective serotonin inhibitor via blocking the reuptake of serotonin. Synonyms: γ -[4- (Trifluoromethyl) phenoxy]benzenepropanamine Hydrochloride; (+/-) -γ -[4- (Trifluoromethyl) phenoxy]benzenepropanamine Hydrochloride; Desmethylfluoxetine Hydrochloride. Grades: > 95%. CAS No. 57226-68-3. Molecular formula: C16H17F3NOCl. Mole weight: 331.77. | |
| Normetanephrine HCl | A derivative of Epinephrine. Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors. Synonyms: DL-α-(Aminomethyl)-4-hydroxy-3-methoxybenzenemethanol hydrochloride; Benzenemethanol, α-(aminomethyl)-4-hydroxy-3-methoxy-, hydrochloride; Benzenemethanol, α-(aminomethyl)-4-hydroxy-3-methoxy-, hydrochloride, (±)-; Vanillyl alcohol, α-(aminomethyl)-, hydrochloride, (±)-; (±)-Normetanephrine hydrochloride; (±)-α-(Aminomethyl)-4-hydroxy-3-methoxybenzyl alcohol hydrochloride; DL-Normetanephrine hydrochloride; Normetadrenaline hydrochloride. Grades: ≥95%. CAS No. 1011-74-1. Molecular formula: C9H13NO3.HCl. Mole weight: 219.67. | |
| Norverapamil | Norverapamil is a metabolite of Verapamil. Verapamil is a medication used for the treatment of high blood pressure, chest pain from not enough blood flow to the heart, and supraventricular tachycardia. Norverapamil is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. Uses: Calcium channel blockers. Synonyms: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile; Verapamil EP Impurity J; Nor Verapamil; NSC672815. Grades: 95%. CAS No. 67018-85-3. Molecular formula: C26H36N2O4. Mole weight: 440.58. | |
| N-Oxacilloilyl (+)-6-Aminopenicillanic Acid Disodium Salt | N-Oxacilloilyl (+)-6-Aminopenicillanic Acid Disodium Salt is a derivative of Oxacillin, which is used as an antibiotic related to Penicillin. Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[ (R) -2-[ (2R, 4S) -4-carboxy-5, 5-dimethyl-2-thiazolidinyl]-2-[[ (5-methyl-3-phenyl-4-isoxazolyl) carbonyl]amino]acetyl]amino]-3, 3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)- (1:2); Disodium (2S,5R,6R)-6-[([(2R,4S)-4-carboxylato-5,5-dimethyl-1,3-thiazolidin-2-yl]{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. Grades: 97%. Molecular formula: C27H29N5Na2O8S2. Mole weight: 661.66. | |
| N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt | N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt is an impurity of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-2-[(2R,4S)-4-carboxy-5,5-dimethyl-2-thiazolidinyl]acetyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)- (1:2); (2S,5R,6R)-6-((2R)-2-(2-Amino-2-(4-hydroxyphenyl)acetamido)-2-((2R,4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Disodium Salt; Disodium (2S,5R,6R)-6-({(2R)-2-{[amino(4-hydroxyphenyl)acetyl]amino}-2-[(2R,4S)-4-carboxylato-5,5-dimethyl-1,3-thiazolidin-2-yl]acetyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. Grades: 90%. Molecular formula: C24H29N5Na2O8S2. Mole weight: 625.62. | |
| N-Phenylcarbamate paroxetine | An impurity of Paroxetine which is a selective serotonin reuptake inhibitor. Synonyms: (-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-phenoxycarbonylpiperidine. CAS No. 253768-88-6. Molecular formula: C26H24FNO5. Mole weight: 449.47. | |
| N-Phenyl Isobutyrylacetamide | N-Phenyl Isobutyrylacetamide is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: 4-methyl-3-oxo-N-phenyl-pentanamide. CAS No. 124401-38-3. Molecular formula: C12H15NO. Mole weight: 205.26. | |
| N-(Pyridin-3-ylmethyl)ethanamine | N-(Pyridin-3-ylmethyl)ethanamine (CAS# 3000-75-7) is used as a reagent in organic synthesis, in particular, that of bis-nicotine derivatives which act as inhibitors of cholinesterases and β-amyloid aggregation. It is also used in the synthesis of [11C]EMPA which acts as a potential PET tracer for orexin 2 receptors. N-(Pyridin-3-ylmethyl)ethanamine is also a nicotinic analog. Synonyms: N-(Pyridin-3-ylmethyl)ethylamine; N-Ethyl-3-pyridinemethanamine; N-Ethyl-N-(3-pyridylmethyl)amine; N-Ethyl-N-(pyridin-3-ylmethyl)amine; N-Ethyl[(3-pyridyl)methyl]amine; N-Ethyl[(pyridin-3-yl)methyl]amine; 3-[(Ethylamino)methyl]pyridine; α-Ethylamino-3-Picoline. Grades: ≥95%. CAS No. 3000-75-7. Molecular formula: C8H12N2. Mole weight: 136.19. | |
| NS-304 | NS-304 is a selective prostacyclin IP1 receptor agonist as prodrug of the active form of MRE-269 with a Ki value of 20 nM. Uses: Antihypertensive agents. Synonyms: Selexipag; NS304; NS 304; ACT-293987; ACT293987; ACT 293987; 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide. Grades: ≥95%. CAS No. 475086-01-2. Molecular formula: C26H32N4O4S. Mole weight: 496.6. | |
| N,S-Carboxymethyl Cysteine HCl | N,S-Carboxymethyl Cysteine HCl is one of Cysteine impurities. It has potential anticancer activity against tumor cell growth. Synonyms: N,S-bis(carboxymethyl)cysteine, hydrochloride (1:1). Grades: > 95%. Molecular formula: C7H11NO6S.HCl. Mole weight: 273.69. | |
| N,S-Dicarboxymethyl-L-cysteine | N,S-Dicarboxymethyl-L-cysteine is an impurity of carbocysteine. Synonyms: N,S-Bis(carboxymethyl)-L-cysteine; Niraparib Impurity compound (c); (2R)-2-(carboxymethylamino)-3-(carboxymethylsulfanyl)propanoic acid; L-Cysteine, N,S-bis(carboxymethyl)-. Molecular formula: C7H11NO6S. Mole weight: 237.23. | |
| NSI-189 | NSI-189 is an experimental drug being studied by Neuralstem, Inc. Research into NSI-189 has been funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) for the treatment of major depressive disorder. NSI-189 successfully completed a phase 1 clinical trial in 2011 where it was administered to 41 healthy volunteers. A phase 1b clinical trial for treating major depressive disorder in 24 patients started in 2012 and completed in July 2014. The study suggests that there were improvements in the patients' condition when the doses were 40/80 mg per day, but no significant improvements were seen for a higher dosage of 120 mg/day. Neuralstem intends to pursue further clinical trials for a variety of neurological conditions, including major depressive disorder, traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder, stroke, and natural cognitive and memory decline in aging. Uses: For research used only. Synonyms: NSI-189; NSI 189; NSI189. Grades: 98%. CAS No. 1270138-40-3. Molecular formula: C22H30N4O. Mole weight: 366.5. | |
| N-Tert-Butyldibenzylamine | An impurity of Terbutaline. Terbutaline is a fast-acting bronchodilator as well as a β2 adrenergic receptor agonist used to treat asthma and premature labor. Synonyms: t-butyldibenzylamine. Grades: 95%. CAS No. 30923-82-1. Molecular formula: C18H23N. Mole weight: 253.38. | |
| N-Trifluoroacetyl Doxorubicin | N-Trifluoroacetyl Doxorubicin is a metabolite of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: N-Trifluoroacetyladriamycin; NSC 283464; (8S-cis)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; (1S,3S)-α-2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-3-glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl L-lyxo-Hexopyranoside; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-. Grades: >95%. CAS No. 26295-56-7. Molecular formula: C29H28F3NO12. Mole weight: 639.53. | |
| N-Trityl Des-4-hydroxy Olmesartan Medoxomil | N-Trityl Des-4-hydroxy Olmesartan Medoxomil is an impurity of Olmesartan Medoxomil. Olmesartan Medoxomil is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. It is a metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50 = 6.18 nM. Synonyms: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(prop-1-en-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carb. CAS No. 1227626-51-8. Molecular formula: C48H42N6O5. Mole weight: 782.88. | |
| N-Trityl Olmesartan Ethyl Ester | N-Trityl Olmesartan Ethyl Ester is an impurity of Olmesartan Medoxomil. Olmesartan Medoxomil is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. It is a metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50 = 6.18 nM. Synonyms: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid Ethyl Ester. CAS No. 172875-59-1. Molecular formula: C45H44N6O3. Mole weight: 716.87. | |
| Nutlin-3 | Nutlin-3 is an MDM2 antagonist, inhibiting p53-Mdm2 interaction (IC50=0.09 μM) via affecting p53 binding pocket of MDM2. It has been studied in anticancer reseaches. Synonyms: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one; 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one. Grades: >98%. CAS No. 548472-68-0. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.49. | |
| Nutlin-3a | Nutlin-3a is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Synonyms: rebemadlin; (-)-Nutlin-3; Nutlin-3a chiral. Grades: >98%. CAS No. 675576-98-4. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.5. | |
| Nutlin-3b | Nutlin-3b, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM. Synonyms: Nutlin-3; nutlin 3; Nutlin 3b; FJA1772CVW; (+)-Nutlin-3; CHEMBL2152332; CHEBI:46742; 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one; 2-Piperazinone, 4-(((4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1H-imidazol-1-yl)carbonyl)-; 4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one; 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one; 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone; cis-4-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazin-2-one. Grades: >98%. CAS No. 675576-97-3. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.49. | |
| Nuzhenide | Cas No. 39011-92-2. | |
| NVP-BSK805 | NVP-BSK805, a quinoxaline derivative, is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis (GI50 < 100 nM) and restrain the growth of JAK2V617F cells (Ba/F3). Synonyms: 4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine; BSK 805; 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline. Grades: 98%. CAS No. 1092499-93-8. Molecular formula: C27H28F2N6O. Mole weight: 490.55. | |
| NVP-HDM201 | NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. Synonyms: Siremadlin; HDM201; HDM 201; HDM-201; NVP-HDM-201; NVP-HDM 201. CAS No. 1448867-41-1. Molecular formula: C26H24Cl2N6O4. Mole weight: 555.41. | |
| NVS-PAK1-1 | NVS-PAK1-1 is potent and specific allosteric PAK1 inhibitor (IC50 = 5 nM) with selective over PAK2 and a panel of 442 kinases. Synonyms: NVS-PAK1-1; NVSPAK11; NVS PAK1 1; (3S)-3-[[8-chloro-11-(2,2-difluoroethyl)-3-fluorobenzo[b][1,4]benzodiazepin-6-yl]amino]-N-propan-2-ylpyrrolidine-1-carboxamide. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93. | |
| O-(2-Propenyl)-Digitoxose 3,4-Diacetate | O-(2-Propenyl)-Digitoxose 3,4-Diacetate is an intermediate in the synthesis of Digoxigenin Tetradigitoxoside, which is an impurity of Digoxin. Synonyms: D-ribo-Hexopyranoside, 2-propenyl 2,6-dideoxy-, diacetate; 2-Propenyl-2,6-dideoxy-D-ribo-hexopyranose 3,4-Diacetate. Molecular formula: C13H20O6. Mole weight: 272.29. | |
| O-(4-Hydroxy-3,5-diiodophenyl)thyroxine | An impurity of Thyroxine which is one of the two major hormones secreted by the thyroid gland and used to stimulate the consumption of oxygen and thus the metabolism of all cells and tissues in the body. Synonyms: O-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-3,5-diiodo-L-tyrosine. Grades: > 95%. CAS No. 911661-90-0. Molecular formula: C21H13I6NO5. Mole weight: 1120.77. | |
| O-Acetyl Cefdinir | O-Acetyl Cefdinir is one of Cefdinir intermediates. Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections. Synonyms: (6R,7R)-7-[[(2Z)-2-[(Acetyloxy)imino]-2-(2-amino-4-thiazolyl)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; [6R-[6α,7β(Z)]]-7-[[[(Acetyloxy)imino](2-amino-4-thiazolyl)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefdinir Impurity S; (6R,7R)-7-((Z)-2-(acetoxyimino)-2-(2-aminothiazol-4-yl)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefdinir CP Impurity S. Grades: 98%. CAS No. 127770-93-8. Molecular formula: C16H15N5O6S2. Mole weight: 437.45. | |
| (O-Acetyl-L-Ser)-Leuprolide | (O-Acetyl-L-Ser)-Leuprolide is an impurity of Leuprolide, which is a synthetic nonapeptide analog of gonadotropin-releasing hormone used as an antineoplastic agent, a gonadotropin-releasing hormone agonist, and an anti-estrogen. Synonyms: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl(Ac)-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; 1-9-Luteinizing hormone-releasing factor (swine), 4-(O-acetyl-L-serine)-6-D-leucine-9-(N-ethyl-L-prolinamide)-; Pyr-His-Trp-Ser(Ac)-Tyr-Leu-Leu-Arg-Pro-NHEt; Ser(Ac)-Leuprolide; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-O-acetyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-; L-pyroglutamyl-L-histidyl-L-tryptophyl-O-acetyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide; Leuprolide Acetate EP Impurity D; Leuprolide Impurity D. Grades: ≥95%. CAS No. 1926163-25-8. Molecular formula: C61H86N16O13. Mole weight: 1251.46. | |
| O-Acetyl N-Benzyloxycarbonyl Valganciclovir | O-Acetyl N-Benzyloxycarbonyl Valganciclovir is a protected Valganciclovir. Synonyms: N-[(PhenylMethoxy)carbonyl]-L-valine 3-(Acetyloxy)-2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]propyl Ester. Grades: > 95%. CAS No. 194159-22-3. Molecular formula: C24H30N6O8. Mole weight: 530.54. | |
| Obatoclax mesylate | Cas No. 803712-79-0. | |
| Obeticholic Acid | Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. It reduced liver fat and reverted cholestasis in a rat model. Synonyms: 6-ECDCA; 6-Ethylchenodeoxycholic acid; Obeticholic acid; INT 747; INT-747; INT747; 6-ECDCA; Ocaliva; (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. Grades: >98%. CAS No. 459789-99-2. Molecular formula: C26H44O4. Mole weight: 420.634. | |
| Oclacitinib | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm). These results demonstrate that oclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs. Synonyms: Cyclohexanemethanesulfonamide, N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, trans-; trans-N-Methyl-4- (methyl-7H-pyrrolo[2, 3-d]pyrimidin-4-ylamino) cyclohexanemethanesulfonamide; JAKi; PF 03394197. Grades: 98%. CAS No. 1208319-26-9. Molecular formula: C15H23N5O2S. Mole weight: 337.44. | |
| Octreotide Acid | Octreotide Acid is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: D-phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cystyl-L-threonine (Disulfide Bridge between Cys2-Cys7); Octreotide Impurity-K; H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OH (Disulfide bridge: Cys2-Cys7); ((4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-L-threonine; L-Threonine, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2?7)-disulfide; Octreotate. CAS No. 96443-50-4. Molecular formula: C49H64N10O11S2. Mole weight: 1033.23. | |
| Octreotide impurity (1.19 RRT) | Octreotide impurity (1.19 RRT) is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(GA)-ol (Disulfide Bridge between Cys2-Cys7); D-phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-(2S,3ξ)-L-threonyl-L-cystyl-(Glycolyl) Threoninol (Disulfide Bridge between Cys2-Cys7). Molecular formula: C51H68N10O12S2. Mole weight: 1077.28. | |
| Octreotide impurity (1.25 RRT) | Octreotide impurity (1.25 RRT) is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(GA)-ol (Disulfide Bridge between Cys2-Cys7); D-phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cystyl-(Glycolyl) Threoninol (Disulfide Bridge between Cys2-Cys7). Molecular formula: C51H68N10O12S2. Mole weight: 1077.28. | |
| Octreotide Specified impurity (2.25 RRT) | Octreotide Specified impurity (2.25 RRT) is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: D-Phe-Cys-Phe-D-Trp-Lys(GA)-Thr-Cys-Thr-ol (Disulfide Bridge between Cys2-Cys7); D-phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl(Glycolyl)-L-threonyl-L-cystyl-Threoninol (Disulfide Bridge between Cys2-Cys7). Molecular formula: C51H68N10O12S2. Mole weight: 1077.28. | |
| O-Demethyl Lenvatinib | One of the impurities of Lenvatinib. Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/&beta. Uses: Antineoplastic agents. Synonyms: 4- (3-chloro-4- ( ( (cyclopropylamino) carbonyl) amino) phenoxy) -7-hydroxy-6-quinolinecarboxamide; Lenvatinib metabolite M2; Lenvatinib O-Desmethyl Impurity. CAS No. 417717-04-5. Molecular formula: C20H17ClN4O4. Mole weight: 412.83. | |
| O-Denaphthyl N-(1-Naphthyl) Duloxetine | O-Denaphthyl N-(1-Naphthyl) Duloxetine is an impurity of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: (S)-3-(Methyl(naphthalen-1-yl)amino)-1-(thiophen-2-yl)propan-1-ol; (1S)-3-[Methyl(1-naphthyl)amino]-1-(2-thienyl)-1-propanol; 2-Thiophenemethanol, α-[2-(methyl-1-naphthalenylamino)ethyl]-, (αS)-. Molecular formula: C18H19NOS. Mole weight: 297.41. | |
| O-Desethyl Azilsartan | O-Desethyl Azilsartan is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: 2-Oxo-3-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-benzimidazole-4-carboxylic acid. CAS No. 1442400-68-1. Molecular formula: C23H16N4O5. Mole weight: 428.40. | |
| O-Desmethyl Adapalene | CD437 is a retinoic acid receptor gamma (RARγ)-selective retinoid agonist shown to effectively inhibit growth and induce apoptosis of a variety of cancer cells. Two forms of dose-dependent action have been reported for this molecule. One mechanism enables induction of apoptosis by a receptor-independent pathway and the other is regulated by a receptor-dependent pathway and is shown to suppress cell differentiation. More recently, Liu, et al. demonstrated the significance of retinoic acid (RA) signaling in reprogramming somatic cells to induced pluripotent stem (iPS) cells. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20 fold. This suggests promoting RA signaling with CD437 may have important implications in reprogramming to a ground-state pluripotency (naïve stem cells). Uses: Reprogramming. Synonyms: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid. Grades: 0.98. CAS No. 125316-60-1. Molecular formula: C27H26O3. Mole weight: 398.49. | |
| O-desmethyl Galantamine | O-desmethyl Galantamine is a metabolite of Galanthamine. Synonyms: (4aS,6R,8aS)-11-Methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol; (1S, 12S, 14R)-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01, 12.06, 17]heptadeca-6(17), 7, 9, 15-tetraene-9, 14-diol; 10-Methyl-galantham-1-ene-3β,6-diol; Sanguinine; O-De. Grades: > 95%. CAS No. 60755-80-8. Molecular formula: C16H19NO3. Mole weight: 273.33. | |
| ODM-201 | ODM-201 is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Synonyms: ODM-201; ODM 201; ODM201. Grades: 98%. CAS No. 1297538-32-9. Molecular formula: C19H19ClN6O2. Mole weight: 389.85. | |
| o-Flutamide | o-Flutamide is an isomer of Flutamide. Synonyms: 2-Methyl-N-[2-nitro-5-(trifluoromethyl)phenyl]propanamide; NSC 674689; Flutamide EP Impurity F. Grades: > 95%. CAS No. 151262-93-0. Molecular formula: C11H11F3N2O3. Mole weight: 276.22. | |
| Oglufanide | Oglufanide is a VEGFR inhibitor that may suppress angiogenesis. Synonyms: IM 862; IM-862; IM862 NSC 334073; NSC-334073; NSC334073; Thymogen; L-glutamyl-L-tryptophan; alpha-Glutamyltryptophan; L-a-Glutamyl-L-tryptophan. Grades: >98%. CAS No. 38101-59-6. Molecular formula: C16H19N3O5. Mole weight: 333.34. | |
| OICR 9429 | OICR-9429 can inhibit the interaction of WDR5 with peptide regions of MLL and histone 3 as a chemical probe. It can reduce viability of acute myeloid leukemia cells and can also disrupt MLL1-RbBP5 interaction. Synonyms: OICR-9429; OICR 9429; OICR9429. N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide. Grades: ≥98% by HPLC. CAS No. 1801787-56-3. Molecular formula: C29H32F3N5O3. Mole weight: 555.59. | |
| Olanzapine EP Impurity C | Olanzapine EP Impurity C is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 1-(chloromethyl)-1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-ium chloride. CAS No. 719300-59-1. Molecular formula: C18H22Cl2N4S. Mole weight: 397.36. | |
| Olanzapine hydrochloride-Bio-X | Olanzapine hydrochloride-Bio-X is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride; 4-Amino-2-methyl-10H-thieno[2,3-b][1,5]-benzodiazapine, Hydrochloride. CAS No. 138564-60-0. Molecular formula: C12H12ClN3S. Mole weight: 265.76. | |
| Olanzapine ketolactam | Olanzapine ketolactam is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: (Z)-4-(4-methylpiperazin-1-yl)-3-(2-oxopropylidene)-1H-benzo[b][1,4]diazepin-2(3H)-one; (3Z)-1,3-Dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one. CAS No. 1017241-34-7. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
| Olanzapine LIP 1 Acetyl | Olanzapine LIP 1 Acetyl is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 1-(4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-yl)ethan-1-one. CAS No. 935272-10-9. Molecular formula: C18H20N4OS. Mole weight: 340.44. | |
| Olanzapine Thiolactam Impurity | Olanzapine thiolactam impurity is a degradation product formed during storage or exposure to thermal stress. Synonyms: Olanapine Ketothiolactam; RT-017506; FT-0673225; 3-[(Z)-2-hydroxyprop-1-enyl]-4-(4-methylpiperazin-1-yl)-1,5-benzodiazepine-2-thione. Grades: ≥95%. CAS No. 1017241-36-9. Molecular formula: C17H20N4OS. Mole weight: 328.43. | |
| Olaparib | Olaparib, also known as AZD-2281 or KU-59436, is a small-molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Synonyms: AZD2281; AZD-2281; AZD 2281; KU59436; KU-59436; KU 59436; KU0059436; KU-0059436; KU 0059436; Olaparib. trade name Lynparza; 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one. Grades: >98%. CAS No. 763113-22-0. Molecular formula: C24H23FN4O3. Mole weight: 434.471. | |
| Oleoyl Chloride | Oleoyl Chloride (CAS# 112-77-6) is used as a chemical reagent in the preparation of Vitamin E analogs as well as antiviral nucleoside phosphoramidate prodrugs used in the treatment of HIV and HBV. Uses: Oleyl chloride is used as a chemical reagent in the preparation of vitamin e analogs as well as antiviral nucleoside phosphoramidate prodrugs used in the treatment of hiv and hbv. Synonyms: Oleoyl Chloride; (Z)-9-Octadecenoyl Chloride; 9-(Z)-Octadecen-1-oyl Chloride; Oleic Acid Chloride; Oleic Chloride; Oleyl Chloride; cis-9-Octadecenoyl Chloride. Grades: ≥95%. CAS No. 112-77-6. Molecular formula: C18H33ClO. Mole weight: 300.91. | |
| Olmutinib | Olmutinib, also called as HM61713 and BI-1482694, is an orally available, mutant-selective third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that is being developed for treatment of advanced and metastatic EGFR mutation-positive non-small cell lung cancer (NSCLC). In May 2016, olmutinib received its first global approval in South Korea for the treatment of EGFR T790M mutation-positive lung cancer. Olmutinib is also a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). Synonyms: N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; HM61713; HM 61713; HM-61713; BI 1482694; BI-1482694; BI1482694; Olmutinib. Grades: >98%. CAS No. 1353550-13-6. Molecular formula: C26H26N6O2S. Mole weight: 486.18. | |
| Olodaterol | Olodaterol is an ultra-long-acting β adrenoreceptor agonist. It can be used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD). Uses: Bronchodilator agents. Synonyms: BI-1744; BI 1744; BI1744; Striverdi. CAS No. 868049-49-4. Molecular formula: C21H26N2O5. Mole weight: 386.4. | |
| Olodaterol Hydrochloride | Olodaterol is an ultra-long-acting β adrenoreceptor agonist. It can be used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD). Uses: Chronic obstructive pulmonary disease. Synonyms: (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride; Olodaterol hydrochloride; Olodaterol HCl; BI-1744; BI 1744; BI1744; Olodaterol; Striverdi. Grades: 98%. CAS No. 869477-96-3. Molecular formula: C21H27ClN2O5. Mole weight: 422.91. | |
| Olsalazine Sodium | Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond. It is used in the treatment of inflammatory bowel disease such as ulcerative colitis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: OLSALAZINE SODIUM; 6054-98-4; Dipentum; Olsalazine Disodium; Disodium 5,5'-azodisalicylate; azodisal sodium; Olsalazine disodium salt; disodium azodisalicylate; CJ 91B; CJ-91B; Olsalazine sodium [USAN]; Olsalazine Sodium Salt; Sodium azodisalicylate; Olsalazine (Disodium); Sodium olsalazine; Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt; C. I. Mordant Yellow 5, disodium salt; Y7JEW0XG7I; Benzoic acid, 3,3'-azobis(6-hydroxy-, disodium salt; sodium (E)-5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoate). Grades: >98%. CAS No. 6054-98-4. Molecular formula: C14H8N2O6.2Na. Mole weight: 346.2. | |
| Omadacycline | Omadacycline is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome. Synonyms: PTK 0796; PTK0796; PTK-0796; Amadacycline. Grades: >98%. CAS No. 389139-89-3. Molecular formula: C29H40N4O7. Mole weight: 556.65. | |
| Omadacycline mesylate | Omadacycline mesylate is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome. Synonyms: PTK 0796 mesylate; PTK-0796 mesylate; PTK0796 mesylate; Amadacycline mesylate. Grades: >98%. CAS No. 1196800-40-4. Molecular formula: C30H44N4O10S. Mole weight: 652.76. | |
| Omadacycline tosylate | Omadacycline tosylate is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome. Grades: >98%. CAS No. 1075240-43-5. Molecular formula: C36H48N4O10S. Mole weight: 728.85. | |
| Omapatrilat | Omapatrilat, an octahydropyridothiazepine derivative, has been found to be an ACE inhibitor as well as an endopeptidase inhibitor and was once studied in heart failure and hypertension. Uses: For research use only. Synonyms: Omapatrilat; BMS 186716; BMS-186716; BMS186716; Vanlev; UNII-36NLI90E7T; CHEMBL289556; (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid. Grades: 98%. CAS No. 167305-00-2. Molecular formula: C19H24N2O4S2. Mole weight: 408.53. | |
| Omarigliptin | Omarigliptin is a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as the treatment for type 2 diabetes. Synonyms: MK-3102; MK3102; MK 3102; (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine. Grades: 98%. CAS No. 1226781-44-7. Molecular formula: C17H20F2N4O3S. Mole weight: 398.429. | |
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