BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| N-Desmethyl Dofetilide | N-Desmethyldofetilide is a derivative of Dofetilide. Synonyms: N- [4- [2- [ [2- [4- [ (Methylsulfonyl) amino] phenoxy] ethyl] amino] ethyl] phenyl] methanesulfonamide. Grades: > 95%. CAS No. 176447-94-2. Molecular formula: C18H25N3O5S2. Mole weight: 427.54. |  |
| N-Desmethyl Dovitinib | Dovitinib derivative. Synonyms: 4-Amino-5-fluoro-3-[6-(1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone. Grades: > 95%. CAS No. 668432-44-8. Molecular formula: C20H19FN6O. Mole weight: 378.41. | |
| N-Desmethyl Doxycycline | N-Desmethyl Doxycycline is a metabolite of Doxycycline, which is a broad-spectrum tetracycline-class antibiotic used in the treatment of infections caused by bacteria and certain parasites. Synonyms: [4S-(4α, 4aα, 5α, 5aα, 6α, 12aα)]-1, 4, 4a, 5, 5a, 6, 11, 12a-Octahydro-3, 5, 10, 12, 12a-pentahydroxy-6-methyl-4-(methylamino)-1, 11-dioxo-2-naphthacenecarboxamide; 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-4-(methylamino)-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)-. Grades: ≥95%. CAS No. 86271-83-2. Molecular formula: C21H22N2O8. Mole weight: 430.41. | |
| N-Desmethyl eletriptan hydrochloride | N-Desmethyl Eletriptan is the N-demethylated analogue of the serotonin 5-HT1 receptor agonist, Eletriptan. Synonyms: (R)-5-[2-(Phenylsulfonyl)ethyl]-3-(2-pyrrolidinylmethyl)-1H-indole Hydrochloride. Grades: > 95%. CAS No. 1391054-78-6. Molecular formula: C21H24N2O2S.HCl. Mole weight: 404.95. | |
| N-Desmethyl Flumatinib | Grades: > 95%. Molecular formula: C28H27F3N8O. Mole weight: 548.58. | |
| N-Desmethyl galantamine | Cas No. 41303-74-6. | |
| N-Desmethyl Imatinib | A metabolite of Imatinib, a tyrosine kinase receptor inhibitor used for cancer therapy. Synonyms: N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide; N-Desmethyl Gleevec. Grades: > 95%. CAS No. 404844-02-6. Molecular formula: C28H29N7O. Mole weight: 479.59. | |
| N-Desmethyl Sorafenib (Pyridine)-N-oxide | N-Desmethyl Sorafenib (Pyridine)-N-oxide is one of Sorafenib metabolites. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide 1-Oxide; BAY 68-7769; N'-desmethylsorafenib N-oxide; N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-1-oxo-(4-pyridyloxy)]phenyl}urea. Grades: 98%. CAS No. 583840-04-4. Molecular formula: C20H14ClF3N4O4. Mole weight: 466.80. | |
| N-Desmethyl Trifluoperazine | N-Desmethyl Trifluoperazine is one of Fluphenazine metabolites. Fluphenazine is a phenothiazine antipsychotic, a dopaminergic antagonist and an antiviral agent. Synonyms: 10-[3-(piperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine; 10-(3-(1-Piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine; 2-(Trifluoromethyl)-10-(3-piperazinopropyl)-10H-phenothiazine; N-deshydroxy-ethyl-fluphenazine. Grades: ≥95%. CAS No. 2804-16-2. Molecular formula: C20H22F3N3S. Mole weight: 393.47. | |
| N-Desmethyl Ulipristal Acetate | N-Desmethyl Ulipristal Acetate is a metabolite of Ulipristal. Ulipristal is a selective progesterone receptor modulator (SPRM) used for emergency contraception and uterine fibroid. Synonyms: (11β)-17-(Acetyloxy)-11-[4-(methylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione; CDB 3877; N-Monodemethyl CDB 2914. CAS No. 159681-66-0. Molecular formula: C29H35NO4. Mole weight: 461.61. | |
| N-Desmethyl Vandetanib | N-Desmethyl Vandetanib is a metabolite of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Synonyms: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazoline. CAS No. 338992-12-4. Molecular formula: C21H22BrFN4O2. Mole weight: 461.34. | |
| Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Synonyms: Necrostatin-1; Necrostatin1; Necrostatin 1; Nec-1; Nec 1; Nec1. Grades: >98%. CAS No. 4311-88-0. Molecular formula: C13H13N3OS. Mole weight: 259.33. | |
| Nefiracetam | Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Uses: Neuroprotective agents. Synonyms: Nefiracetam; 77191-36-7; N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; Translon; DM 9384. Grades: >98%. CAS No. 77191-36-7. Molecular formula: C14H18N2O2. Mole weight: 246.3. | |
| Nelarabine | Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. Synonyms: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; Arranon; MAY; Nelzarabine; 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine; NSC-686673; (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Grades: ≥98% by HPLC. CAS No. 121032-29-9. Molecular formula: C11H15N5O5. Mole weight: 297.27. | |
| Neophytadiene | Neophytadiene is an enzyme inhibitor. Synonyms: 2-(4,8,12-Trimethyltridecyl)buta-1,3-diene; 7,11,15-trimethyl-3-methylidenehexadec-1-ene. CAS No. 504-96-1. Molecular formula: C20H38. Mole weight: 278.52. | |
| Neratinib | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Synonyms: HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272. Grades: >98%. CAS No. 698387-09-6. Molecular formula: C30H29ClN6O3. Mole weight: 557.051. | |
| Neratinib Dimethylamine-N-oxide (M7) | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethyloxidoamino)-, (2E)-. Grades: ≥95%. CAS No. 1376615-55-2. Molecular formula: C30H29ClN6O4. Mole weight: 573.04. | |
| Neratinib Impurity QL | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity QL. Grades: ≥95%. CAS No. 1469746-91-5. Molecular formula: C30H30N6O3. Mole weight: 522.60. | |
| Neratinib Impurity QLAJ | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H21N5O2. Mole weight: 411.47. | |
| Neratinib Impurity SMQA | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C12H11ClN2O2. Mole weight: 250.68. | |
| Neratinib Impurity SMYXJ | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C12H9ClN2O2. Mole weight: 248.67. | |
| Neratinib Impurity XA | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: (E)-4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline-3-carboxamide; 1376619-98-5. Grades: ≥95%. CAS No. 1376619-98-5. Molecular formula: C30H31ClN6O4. Mole weight: 575.06. | |
| Neratinib Impurity XAAJ | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Grades: ≥95%. Molecular formula: C24H22ClN5O3. Mole weight: 463.92. | |
| Nestoron | Nestorone is a steroidal progestin of the 19-norprogesterone group which is used as a hormonal contraceptive in several South American countries. It is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. It has been used as a female contraceptive and may be useful as a male contraceptive too recently. It does not bind to the estrogen receptor either, but it has some affinity for the glucocorticoid receptor. It appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. It has been shown to have neurogenic and neuroprotective activity. It holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. It protected against hippocampus abnormalities and improved functional outcomes of EAE mice, which suggests its potential value. It lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects. Uses: Nestorone is used as a hormonal contraceptive in several south american countries. it has been used as a female contraceptive and may be useful as a male contraceptive too recently. it lacks affinity for the androgen receptor, thus does not produce any androgenic or anabolic effects. Synonyms: ST-1435; ST1435; ST1435; Elcometrine; Nestorone; segesterone acetate; 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate; Elcometrine; 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate; Segesterone acetate; [(8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-16-methylidene-3-oxo-2,6,7,8,9,10,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate. Grades: 95%. CAS No. 7759-35-5. Molecular formula: C23H30O4. Mole weight: 370.48. | |
| Netarsudil Mesylate | Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and?/or reducing intraocular pressure. CAS No. 1422144-42-0. Molecular formula: C30H35N3O9S2. Mole weight: 645.742. | |
| N-Ethanone Oxcarbazepine | An impurity of Oxcarbazepine which is used as an anticonvulsant by slowing abnormal nerve impulses in the brain. Synonyms: Oxcarbazepine Related Compound B; Oxcarbazepine Impurity 003. Grades: 95%. Molecular formula: C17H14N2O3. Mole weight: 294.30. | |
| N-Ethoxycarbonyl Dabigatran Ethyl Ester | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, showing that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Synonyms: Ethyl 3- (2- ( ( (4- (N- (Ethoxycarbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate. Grades: ≥95%. CAS No. 1416446-40-6. Molecular formula: C30H33N7O5. Mole weight: 571.64. | |
| N-ethyl-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide | An impurity of Parecoxib which is a COX2 selective inhibitor and a water-soluble and injectable prodrug of valdecoxib. Synonyms: Benzenesulfonamide, N-ethyl-4-(5-methyl-3-phenyl-4-isoxazolyl)-; Parecoxib Impurity 28. CAS No. 473465-11-1. Molecular formula: C18H18N2O3S. Mole weight: 342.41. | |
| N-Ethylbenzylamine | An impurity of Etilefrin. Etilefrin is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Uses: N-ethylbenzylamine is a reactant or reagent used in various organic syntheses. it is used in the preparation of cxcr4 injhibitors which are used to treat cancer metastasis and inflammation. Synonyms: N-benzylethanamine. Grades: > 95 %. CAS No. 14321-27-8. Molecular formula: C9H13N. Mole weight: 135.21. | |
| N-Ethyl Esmolol | N-Ethyl Esmolol is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Synonyms: methyl-3-(4-(2-hydroxy-3-(ethylamino)-propoxyl)phenyl)propionate. Grades: >95%. Molecular formula: C15H23NO4. Mole weight: 281.35. | |
| N-Ethyl Esmolol HCl | N-Ethyl Esmolol HCl is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Synonyms: methyl-3-(4-(2-hydroxy-3-(ethylamino)-propoxyl)phenyl)propionate hydrochloride. Molecular formula: C15H23NO4.HCl. Mole weight: 317.81. | |
| N-Ethyl Fingolimod | An impurity of Fingolimod. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Synonyms: 2-(ethylamino)?-2-[2-(4-octylphenyl)?ethyl]?-1,?3-Propanediol. Grades: > 95%. CAS No. 1402793-28-5. Molecular formula: C21H37NO2. Mole weight: 335.53. | |
| Netupitant | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant. Grades: >98%. CAS No. 290297-26-6. Molecular formula: C30H32F6N4O. Mole weight: 578.603. | |
| Neuropeptide Y (human, rat) | Neuropeptide Y (human, rat) is a widely distributed endogenous neuropeptide involved in the control of food intake, sexual behavior and blood pressure. NPY has also been shown to interact with the immune system, promoting gastrointestinal inflammation, as well as exhibiting an antimicrobial effect against several gut bacteria. Synonyms: NPY (human, rat). CAS No. 90880-35-6. Molecular formula: C189H285N55O57S. Mole weight: 4271.7. | |
| NFAT Inhibitor | A selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Synonyms: H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH; L-methionyl-L-alanyl-glycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonyl-glycyl-L-prolyl-L-histidyl-L-alpha-glutamyl-L-glutamic acid. Grades: >98%. CAS No. 249537-73-3. Molecular formula: C75H118N20O22S. Mole weight: 1683.93. | |
| N-FMOC Mitomycin C | N-FMOC Mitomycin C is used to protect Mitomycin C, an anti-tumor antibiotic. Synonyms: N-FMOC [1aS-(1aα, 8β, 8aα, 8bα)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1, 1a, 2, 8, 8a, 8b-hexahydro-8a-methoxy-5-methylazirino[2, '3':3, 4]pyrrolo[1, 2-a]indole-4, 7-dione. Molecular formula: C30H28N4O7. Mole weight: 556.56. | |
| N-Formyl 10-Oxo 7-Epi-docetaxel | N-Formyl 10-Oxo 7-Epi-docetaxel is an impurity of Docetaxel, which is a semisynthetic derivative of Paclitaxel used to treat a variety of cancers, including breast, head and neck, stomach, prostate, and non-small cell lung cancer. Synonyms: (2α, 5β, 7α, 13α)-4-Acetoxy-13-{[(2R, 3S)-3-formamido-2-hydroxy-3-phenylpropanoyl]oxy}-1, 7-dihydroxy-9, 10-dioxo-5, 20-epoxytax-11-en-2-yl benzoate; Benzenepropanoic acid, β-(formylamino)-α-hydroxy-, (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-. Molecular formula: C39H43NO13. Mole weight: 733.76. | |
| N-Formyl 10-Oxo Docetaxel | N-Formyl 10-Oxo Docetaxel is an impurity of Docetaxel, which is a semisynthetic derivative of Paclitaxel used to treat a variety of cancers, including breast, head and neck, stomach, prostate, and non-small cell lung cancer. Synonyms: (2α,5β,7β,13α)-4-Acetoxy-13-{[(2R,3S)-3-formamido-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9,10-dioxo-5,20-epoxytax-11-en-2-yl benzoate; Benzenepropanoic acid, β-(formylamino)-α-hydroxy-, (2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-. Grades: 95%. Molecular formula: C39H43NO13. Mole weight: 733.76. | |
| N-Formyl ampicilloic acid | An impurity of Ampicillin, an antibiotic used for the treatment of various bacterial infections. Synonyms: (4S)-2-{[(R)-2-Amino-2-phenylacetamido](carboxy)methyl}-3-formyl-5,5-dimethylthiazolidine-4-carboxylic acid. Molecular formula: C17H21N3O6S. Mole weight: 395.43. | |
| N-Formyl Atomoxetine | N-Formyl Atomoxetine is a derivative of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Synonyms: Atomoxetine Impurity 5; N-[(3R)-3-(2-methylphenoxy)-3-phenylpropyl]-N-methylformamide; N-Formyl Tomoxetine. Molecular formula: C18H21NO2. Mole weight: 283.36. | |
| N-Formylbisoprolol | N-Formylbisoprolol is an impurity of Bisoprolol, a medication used for the treatment of hypertension, heart failure and other heart diseases. Synonyms: N- (2-hydroxy-3- (4- ( (2-isopropoxyethoxy) methyl) phenoxy) propyl) -N-isopropylformamide; N-Formyl Bisoprolol. CAS No. 1447715-45-8. Molecular formula: C19H31NO5. Mole weight: 353.45. | |
| N-Formylcytisine | N-Formylcytisine is a derivative of Cytisine, which is a nicotinic acetylcholine receptor (nAChR) agonist. Synonyms: (1R,5S)-1,5,6,8-Tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocine-3(4H)-carboxaldehyde; (1R)-1,5,6,8-Tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocine-3(4H)-carboxaldehyde; (-)-N-Formylcytisine. Grades: ≥95%. CAS No. 53007-06-0. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
| N-Formyl-L-kynurenine | N-Formylkynurenine is a L-kynurenine derivative. Synonyms: (S)-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid. CAS No. 3978-11-8. Molecular formula: C11H12N2O4. Mole weight: 236.22. | |
| N-Formyl Trimetazidine HCl | An impurity of Trimetazidine. Trimetazidine is a drug for angina pectoris. Synonyms: 4-(2,3,4-Trimethoxybenzyl)-1-piperazine-carboxaldehyde hydrochloride; 4-(2,3,4-Trimethoxybenzyl)piperazine-1-carbaldehyde hydrochloride. CAS No. 879646-17-0. Molecular formula: C15H22N2O4.HCl. Mole weight: 330.81. | |
| N-Hydroxy Palbociclib | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Palbociclib metabolite M7; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-((5-(4-hydroxy-1-piperazinyl)-2-pyridinyl)amino)-5-methyl-. Grades: ≥95%. CAS No. 2231085-26-8. Molecular formula: C24H29N7O3. Mole weight: 463.53. | |
| Nicardipine Hydrochloride | Nicardipine is a calcium channel blocker used to treat high blood pressure and angina. Synonyms: RS-69216; RS 69216; RS69216; YC-93; YC 93; YC93. Grades: >98% (HPLC). CAS No. 54527-84-3. Molecular formula: C26H29N3O6.HCl. Mole weight: 515.99. | |
| Nicotelline | Nicotelline is one of Nicotine related metabolites, which is a potent parasympathomimetic stimulant. Synonyms: 3,2':4',3''-Terpyridine; Nicotellin; 2,4-Di(3-pyridyl)pyridine; 2,4-Di(b-pyridyl)pyridine; 2,4-bis(3-pyridyl)pyridine; 2,4-Bis(pyridin-3-yl)pyridine. Grades: 98%. CAS No. 494-04-2. Molecular formula: C15H11N3. Mole weight: 233.27. | |
| (-)-Nicotine Hemisulfate Salt | Cas No. 65-30-5. | |
| Nifurtimox | Nifurtimox is a 5-nitrofuran and is used to treat diseases caused by trypanosomes including Chagas disease and sleeping sickness. It is given by mouth and not by injection. Nifurtimox is now in a Phase II clinical trial for the treatment of pediatric neuroblastoma and medulloblastoma. Nifurtimox decreased cell viability in a concentration-dependent manner. Nifurtimox also suppressed basal and TrkB-mediated Akt phosphorylation, and the cytotoxicity of nifurtimox was attenuated by a tyrosine hydroxylase inhibitor (alpha-methyl-tyrosine). Nifurtimox killed catecholaminergic, but not cholinergic, autonomic neurons in culture. In vivo xenograft models showed inhibition of tumor growth with a histologic decrease in proliferation and increase in apoptosis. These results suggest that nifurtimox induces cell death in neuroblastoma. Therefore, further studies are warranted to develop nifurtimox as a promising new treatment for neuroblastoma. Uses: Trypanocidal agents. Synonyms: BAY 2502; BAY2502; BAY-2502; Bayer 2502; Bayer2502; Bayer-2502; Lampit. Grades: >98%. CAS No. 23256-30-6. Molecular formula: C10H13N3O5S. Mole weight: 287.29. | |
| NIK SMI1 | NIK SMI1 is a potent and selective NF-κB inducing kinase (NIK) inhibitor. Synonyms: (R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide. CAS No. 1660114-31-7. Molecular formula: C20H19N3O4. Mole weight: 365.4. | |
| Nilotinib monohydrochloride monohydrate | Nilotinib monohydrochloride monohydrate is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. It binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. It also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). Uses: Tyrosine kinase inhibitors. Synonyms: AMN-107; AMN 107; AMN107; Tasigna. Grades: >98%. CAS No. 923288-90-8. Molecular formula: C28H25ClF3N7O2. Mole weight: 583.99. | |
| Nilutamide | Nilutamide is a non-steroidal and silent antiandrogen that binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Uses: Antineoplastic agents. Synonyms: Anandron; Nilandron; 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione. Grades: >98%. CAS No. 63612-50-0. Molecular formula: C12H10F3N3O4. Mole weight: 317.224. | |
| Nintedanib Acetyl Impurity | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (3Z)-1H-Indole-6-carboxylic acid, 3-[[[4- (acetylmethylamino) phenyl]amino]phenylmethylene]-2, 3-dihydro-2-oxo-, methyl ester. Grades: ≥95%. CAS No. 1139458-48-2. Molecular formula: C26H23N3O4. Mole weight: 441.48. | |
| Nintedanib dimer | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: 2,2'-(Piperazine-1,4-diyl)bis(N-(4-aminophenyl)-N-methylacetamide). Grades: 95% by HPLC. CAS No. 2410284-89-6. Molecular formula: C22H30N6O2. Mole weight: 410.51. | |
| Nintedanib Ethanesulfonate (Intedanib Ethanesulfonate) | Nintedanib esylate is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/&beta. Uses: The treatment of idiopathic pulmonary fibrosis. Synonyms: Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate; BIBF1120; BIBF 1120 BIBF-1120; Nintedanib esylate Nintedanib ethanesulfonate salt; Intedanib; Brand name OFEV Vargatef. Grades: >98%. CAS No. 656247-18-6. Molecular formula: C33H39N5O7S. Mole weight: 649.76. | |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Synonyms: BIBF-1202; BIBF 1202; BIBF1202. (3Z) -2, 3-Dihydro-3- [ [ [4- [methyl [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. Grades: >98%. CAS No. 894783-71-2. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| Nintedanib Impurity D | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (3Z) ?-2, ?3-Dihydro-3-[[[4- (methylamino) ?phenyl]?amino]?phenylmethylene]?-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester. Grades: >95%. CAS No. 1987887-92-2. Molecular formula: C24H21N3O3. Mole weight: 399.45. | |
| Nintedanib Impurity Dimer | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. CAS No. 2410649-56-6. Molecular formula: C56H52N8O8. Mole weight: 965.06. | |
| Nintedanib Impurity I | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate; NINTEDANIB IMPURITY I; 3TK2E45UHG; BIBF1053; Nintedanib metabolite M3 (m/Z 526); (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate ( Nintedanib Impurity); 1H-Indole-6-carboxylic acid, 2, 3-dihydro-3- ( ( (4- (methyl (2- (1-piperazinyl) acetyl) amino) phenyl) amino) phenylmethylene) -2-oxo-, methyl ester, (3Z)-; methyl 2-hydroxy-3-[N-[4-[methyl-(2-piperazin-1-ylacetyl)amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate. Grades: ≥95%. Molecular formula: C14H22N4O2. Mole weight: 278.36. | |
| Nintedanib Impurity J | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H42N8O2. Mole weight: 522.70. | |
| Nintedanib Impurity K | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H40N8O2. Mole weight: 520.68. | |
| Nintedanib Impurity L | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H40N8O3. Mole weight: 536.68. | |
| Nintedanib Impurity N'-oxide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C31H33N5O5. Mole weight: 555.64. | |
| N-Isopropylnoradrenochrome | N-Isopropylnoradrenochrome is an impurity of Isoproterenol, which is a non-selective β-adrenoceptor agonist used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. Synonyms: 1-Isopropylnoradrenochrome; Aludrinochrome; Isoproterenol Aminochrome; Isoproteroquinone; N-Isopropylnoradrenochrome; 2,3-Dihydro-3-hydroxy-1-(1-methylethyl)-1H-indole-5,6-dione. Grades: ≥95%. CAS No. 3736-31-0. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| Nisoxetine Hydrochloride | Nisoxetine hydrochloride is a high affinity (IC50 = 1 nM) inhibitor of the presynaptic norepinephrine (NE) reuptake system, with little or no affinity for a range of other neurotransmitter receptors. Synonyms: Lilly 94939; NSC 298819; Nisoxetine Hydrochloride; (±)γ-(2-Methoxyphenoxy)-N-methyl-Benzenepropanamine Hydrochloride. Grades: ≥99% by HPLC. CAS No. 57754-86-6. Molecular formula: C17H22ClNO2. Mole weight: 307.82. | |
| Nitrofurantoin Impurity | An impurity of Nitrofurantoin, which is an antibioticused to treat urinary tract infections, is not effective for kidney infections. Synonyms: 2-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid; [(5-Nitrofurfurylidene)hydrazino]acetic Acid. Grades: > 95%. CAS No. 91447-38-0. Molecular formula: C7H6N3O5Na. Mole weight: 235.13. | |
| Nitrofurantoin related compound A | Nitrofurantoin related compound A is a new derivative of 5-Nitro-2-furfural. It is proved to be bactericidal. Synonyms: 3-(5-Nitrofurfurylideneamino)hydantoic acid; N-(Aminocarbonyl)-N-{[(5-nitro-2-furanyl)methylene]amino}glycine; 2-[1-Carbamoyl-2-(5-nitrofurfurylidene)hydrazino]acetic acid; 2-[1-(Aminocarbonyl)-2-[(5-nitro-2-furanyl)methylene]hydrazinyl]acetic Acid; [(Aminoca. Grades: > 95%. CAS No. 63981-22-6. Molecular formula: C8H8N4O6. Mole weight: 256.17. | |
| NLG-919 | NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Synonyms: GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078. Grades: > 98%. CAS No. 1402836-58-1. Molecular formula: C18H22N2O. Mole weight: 282.38. | |
| N-(L-Valyl) Valganciclovir Hydrochloride | N-(L-Valyl) Valganciclovir Hydrochloride is a dipeptide monoester prodrugs of the antiviral drug Ganciclovir. Synonyms: L-Valyl-L-valine 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3- hydroxypropyl Ester Hydrochloride. Grades: > 95%. Molecular formula: C19H32N7O6Cl. Mole weight: 489.96. | |
| N-Methoxycarbonyl Dabigatran Ethyl Ester | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, showing that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Synonyms: N-[[2-[[[4-[Imino[ (methoxycarbonyl) amino]methyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β -alanine Ethyl Ester; Ethyl 3- (2- ( ( (4- (N- (methoxycarbonyl) carbamimidoyl) phenyl) amino) methyl) -1-methyl-N- (pyridin-2-yl) -1H-benzo[d]imidazole-5-carboxamido) propanoate. Grades: ≥95%. CAS No. 211914-96-4. Molecular formula: C29H31N7O5. Mole weight: 557.61. | |
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