BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Palosuran | Palosuran is a new Urotensin-II receptor antagonist (IC50=3.6±0.2 nM). Uses: Urotensin-ii receptor antagonist. Synonyms: 1-[2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea;ACT-058362; ACT058362; ACT 058362. Grades: ≥95%. CAS No. 540769-28-6. Molecular formula: C25H30N4O2. Mole weight: 418.54. |  |
| Palovarotene | Palovarotene is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema. In small animal studies, palovarotene was claimed to reverse the structural, functional and inflammatory features of cigarette smoke-induced emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Synonyms: 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic Acid; R 667; Ro 3300074; 4-{(E)-2-[5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydro-2-naphthalenyl]vinyl}benzoic acid; (E)-4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid. Grades: 98%. CAS No. 410528-02-8. Molecular formula: C27H30N2O2. Mole weight: 414.54. | |
| Pam3CSK4 | Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection. Synonyms: Pam3-Cys-Ser-Lys-Lys-Lys-Lys; (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH; P3CSK4; Pam3Cys-SK4; TLR1/TLR2 Agonist I; Pam3Cys-Ser-(Lys)4; Synthetic Triacylated Lipopeptide; L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N2-[N-[S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl]-L-seryl]-L-lysyl]-L-lysyl]-L-lysyl]-; S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine; P 3C; Pam3Cys-SKKKK; Pam3CysSK4. Grades: ≥95%. CAS No. 112208-00-1. Molecular formula: C81H156N10O13S. Mole weight: 1510.23. | |
| Pamapimod | A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate. Synonyms: 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; R 1503; R-1503; R1503; Ro 4402257; Ro4402257; Ro-4402257. Grades: 99%. CAS No. 449811-01-2. Molecular formula: C19H20F2N4O4. Mole weight: 406.39. | |
| Paquinimod | Paquinimod, also known as ABR - 215757, belonging to the class of quinoline-3-carboxamide derivatives, is a S100A9 inhibitor. Paquinimod is an immunomodulatory compound that reduces pathology in experimental collagenase-induced osteoarthritis. Synonyms: N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide; ABR - 215757; ABR 215757; ABR215757; Paquinimod. Grades: 95%. CAS No. 248282-01-1. Molecular formula: C21H22N2O3. Mole weight: 350.42. | |
| PAR-2 (1-6) (mouse, rat) | PAR-2 (1-6) (mouse, rat) is a PAR2 activator. It can be used to explore signaling through PAR2 in cells. Synonyms: H-Ser-Leu-Ile-Gly-Arg-Leu-OH; Proteinase Activated Receptor 2 Agonist Peptide (SLIGRL), mouse; Ser-Leu-Ile-Gly-Arg-Leu; PAR-2 Agonist Peptide (SLIGRL), mouse. Grades: 98%. CAS No. 164081-25-8. Molecular formula: C29H55N9O8. Mole weight: 657.8. | |
| PAR4 (1-6) (human) | PAR4 (1-6) is a synthetic hexapeptide agonist of proteinase-activated receptor 4 (PAR4). PAR4 is a thrombin receptor activated by platelet, and acts as a modulator of cellular responses that serve as hallmarks of inflammation. Synonyms: H-Gly-Tyr-Pro-Gly-Gln-Val-OH; (2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoic acid. Grades: 98%. CAS No. 225779-44-2. Molecular formula: C28H41N7O9. Mole weight: 619.67. | |
| para-Cypermethrin | para-Cypermethrin, structurally related to cypermethrin, is a synthetic pyrethroid insecticide used on cotton trees, fruit trees and vegetables. Synonyms: 3-(2,2-Dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid Cyano(4-phenoxyphenyl)methyl Ester; Cypermethrin Impurity 2 (Mixture Of Diastereomers); Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(4-phenoxyphenyl)methyl ester; 3-(2,2propCyano(4-phenoxyphenyl)methyl Ester. Grades: ≥95%. CAS No. 61732-64-7. Molecular formula: C22H19Cl2NO3. Mole weight: 416.30. | |
| para-Hydroxy Elvitegravir (Elvitegravir M1) | Synonyms: p-Hydroxy elvitegravir; Elvitegravir (m1); 870648-10-5; UNII-7H5PG477IY; 7H5PG477IY; para-Hydroxy Elvitegravir (Elvitegravir M1); 3-Quinolinecarboxylic acid, 6-((3-chloro-2-fluoro-4-hydroxyphenyl)methyl)-1,4-dihydro-1-((1S)-1-(hydroxymethyl)-2-methylpropyl)-7-methoxy-4-oxo-; 6-[(3-chloro-2-fluoro-4-hydroxyphenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid; SCHEMBL4360750; DTXSID50870376; Q27268282. Grades: > 95%. CAS No. 870648-10-5. Molecular formula: C23H23ClFNO6. Mole weight: 463.89. | |
| para-Hydroxy Felbamate | An impurity of Felbamate. Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site. Synonyms: 4-Hyrdroxy Felbamate; 2-(4-Hydroxyphenyl)-1,3-propanediyl Dicarbamate. Grades: > 95%. CAS No. 109482-28-2. Molecular formula: C11H14N2O5. Mole weight: 254.24. | |
| Parallel Dimer-AVP | Parallel Dimer-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: Parallel Dimer Vasopressin; H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2.H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys1', Cys6-Cys6'); 2[L-cystyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparginyl-L-cystyl-L-prolyl-L-arginyl-glycinamide] (inter-disulfide bridges between 1,1' and 6,6' cysteines). Molecular formula: C92H130N30O24S4. Mole weight: 2168.48. | |
| Parallel Dimer-Oxytocin | Parallel Dimer-Oxytocin is an impurity of Oxytocin, which is a mammalian neurohypophysial hormone used as a vasodilator agent. Synonyms: 2[L-cystyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparginyl-L-cystyl-L-leucyl-L-prolyl-L-glycinamide] (inter-disulfide bridges between 1,1' and 6,6' cysteines); Oxytocin parallel dimer; α-Oxytocin dimer; L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide (1->1'),(6->6')-bis(disulfide) compound with L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide; Glycinamide, L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-, bimol. cyclic (1?1'),(6?6')-bis(disulfide); H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2.H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys1', Cys6-Cys6'). Grades: ≥95%. CAS No. 19645-28-4. Molecular formula: C86H132N24O24S4. Mole weight: 2014.39. | |
| Paramethasone | Paramethasone, a derivative of dexamethasone, is a glucocorticoid drug with anti-inflammatory and immunosuppressant properties. Synonyms: (6α,11β,16α)-6-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione; 6α-Fluoro-11β,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione; 16α-Methyl-6α-fluoroprednisolone; 6α-Fluoro-16α-methylprednisolone; Cortiden. Grades: ≥95%. CAS No. 53-33-8. Molecular formula: C22H29FO5. Mole weight: 392.47. | |
| Paramethasone Acetate | Paramethasone Acetate, a derivative of dexamethasone, has been found to be a glucocorticoid drug and could be used in some inflammatory diseases. Synonyms: (6α,11β,16α)-21-(Acetyloxy)-6-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; 16α-Methyl-6α-fluoroprednisolone 21-acetate; 21-Acetyl-6α-fluoro-16α-methylprednisolone; 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Acetate; Alondra; Cortidene; Dilar; Dillar; Flumethone; Haldrate; Haldrone; Metilar; Monocortin; Paramethasone 21-acetate; Paramethasone Acetate; Paramezone; Stemex; Syntecort. Grades: 98%. CAS No. 1597-82-6. Molecular formula: C24H31FO6. Mole weight: 434.50. | |
| Para-Naphthol Duloxetine | Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Synonyms: 4-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol; Duloxetine EP Impurity C; Duloxetine impurity C; 1-Naphthalenol, 4-[3-(methylamino)-1-(2-thienyl)propyl]-; (RS)-4-(3-Methylamino-1-thiophen-2-yl-propyl)-naphthalen-1-ol; Duloxetine metabolite Para-Naphthol Duloxetine. Grades: ≥95%. CAS No. 949095-98-1. Molecular formula: C18H19NOS. Mole weight: 297.42. | |
| Parecoxib Impurity 1 | An impurity of Parecoxib. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. Synonyms: Valdecoxib Disulfonamide Impurity; Parecoxib Impurity H. Grades: 95%. CAS No. 1708094-99-8. Molecular formula: C22H23N3O7S2. Mole weight: 505.56. | |
| Parecoxib Impurity 24 | An impurity of Parecoxib. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. Synonyms: N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyramide; 2-methyl-N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide; Propanamide, 2-methyl-N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-; SCHEMBL5069872; DTXSID50627261; AS-80624; CS-0255351; F83303; 2-Methyl-N-[[4- (5-methyl-3-phenyl-4-isoxazolyl) phenyl]sulfonyl]propanamide; 2-Methyl-N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonyl]propanamide; 2-METHYL-N-[4-(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)BENZENESULFONYL]PROPANAMIDE; N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyramide (Palbociclib Impurity). Grades: 95%. CAS No. 198470-82-5. Molecular formula: C20H20N2O4S. Mole weight: 384.45. | |
| Parecoxib Impurity 4 | Cas No. 181695-72-7. | |
| Parecoxib Impurity HSJZ | An impurity of Parecoxib which is a COX2 selective inhibitor and a water-soluble and injectable prodrug of valdecoxib. Grades: ≥95%. Molecular formula: C17H15NO4S. Mole weight: 329.37. | |
| Parecoxib Impurity HSYBZ | An impurity of Parecoxib which is a COX2 selective inhibitor and a water-soluble and injectable prodrug of valdecoxib. Grades: ≥95%. Molecular formula: C19H19NO4S. Mole weight: 357.42. | |
| Paricalcitol | Synthetic analog of vitamin D. Antihyperparathyroid. Synonyms: Zemplar. Grades: >98%. CAS No. 131918-61-1. Molecular formula: C27H44O3. Mole weight: 416.64. | |
| Paricalcitol Impurity 2 | An impurity of Paricalcitol which is used to treat and prevent secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Grades: > 95%. Molecular formula: C19H34O2. Mole weight: 294.48. | |
| Paricalcitol Impurity 5 | Paricalcitol Impurity 5 is an impurity of paricalcitol, an analogue of vitamin D2. Paricalcitol is a medication used for the treatment of secondary hyperparathyroidism. Synonyms: 14-epi-PRC-2; PL-A'. Molecular formula: C19H32O2. Mole weight: 292.46. | |
| Paricalcitol Sulfate | An impurity of Paricalcitol which is used to treat and prevent secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Grades: > 95%. Molecular formula: C27H44O6S. Mole weight: 496.71. | |
| Parimifasor | Parimifasor is an immunomodulator that exhibits anti-inflammatory activity. It is a potential therapy for inflammatory bowel disease (IBD). Synonyms: 3-chloro-N-[(3-chloro-5-fluoroanilino)-[[5-(trifluoromethyl)-1H-pyrazol-3-yl]amino]methylidene]benzamide. CAS No. 1796641-10-5. Molecular formula: C18H11Cl2F4N5O. Mole weight: 460.214. | |
| Paritaprevir | Paritaprevir could inhibit viral phosphoprotein NS5A and is significant to viral replication and other activities. It also has been found to have potential effect agains hepatitis C virus. Synonyms: ATB450; ABT-450; ABT 450; Paritaprevir; Veruprevir; Brand name: VIEKIRA PAK. Grades: 99.89%. CAS No. 1216941-48-8. Molecular formula: C40H43N7O7S. Mole weight: 765.886. | |
| Paroxetine EP Impurity A HCl | An impurity of Paroxetine which is the first antidepressant to treat panic disorder formally approved in the United States. Synonyms: Paroxetine EP Impurity A hydrochloride; Paroxetine HCl EP Impurity A; Desfluoro-Paroxetine HCl; Desfluoro-Paroxetine hydrochloride. Grades: > 95%. CAS No. 1394842-91-1. Molecular formula: C19H21NO3.HCl. Mole weight: 347.84. | |
| Paroxetine Hydrochloride Hemihydrate EP Impurity C | An impurity of Paroxetine which is a selective serotonin reuptake inhibitor. Synonyms: 4-Ethoxy Paroxetine Hydrochloride; trans-(+/-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl) piperidine Hydrochloride; rac-trans-4-Defluoro-4-ethoxy Paroxetine Hydrochloride. CAS No. 1346597-97-4. Molecular formula: C21H26ClNO4. Mole weight: 391.89. | |
| Pasireotide | Pasireotide pamoate, also known as SOM230, is an orphan drug approved for the treatment of Cushing's disease in patients who fail or are ineligible for surgical therapy. It was developed by Novartis. Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. Synonyms: Pasireotide; SOM230; SOM-203; SOM 203; Signifor. Grades: >98%. CAS No. 396091-73-9. Molecular formula: C58H66N10O9. Mole weight: 1047.227. | |
| Pazopanib HCl | Pazopanib is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. Synonyms: TMC-114, UIC 94017. Grades: >98%. CAS No. 635702-64-6. Molecular formula: C21H23N7O2·HCl. Mole weight: 473.98. | |
| Pazufloxacin isomer Impurity | Pazufloxacin isomer Impurity is an impurity of Pazufloxacin. Pazufloxacin is a fluoroquinolone antibiotic. Synonyms: (R)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3R)-. CAS No. 166665-94-7. Molecular formula: C16H15FN2O4. Mole weight: 318.30. | |
| PD123319 | PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. Uses: Vasoconstrictor agents. Synonyms: PD123319; PD 123319; PD-123319; (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid; (S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid; (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid; (S)-(+)-PD 123319; PD 123319. Grades: >98%. CAS No. 130663-39-7. Molecular formula: C31H32N4O3. Mole weight: 508.61. | |
| PD-173955 | PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Synonyms: PD173955; PD 173955; PD-173955. Grades: 0.98. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. | |
| PD-1-IN-17 | PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 12), inhibits 92% splenocyte proliferation at 100 nM. Synonyms: PD1-IN-1. CAS No. 1673560-66-1. Molecular formula: C13H22N6O7. Mole weight: 374.35. | |
| PDS-0330 | PDS-0330 is a specific and potent Claudin-1 inhibitor. CAS No. 2904682-19-3. Molecular formula: C25H17N3O2S. Mole weight: 423.49. | |
| Pemetrexed Diethyl Ester | Pemetrexed diethyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Diethyl 2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate; (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester. Grades: ≥95%. CAS No. 146943-43-3. Molecular formula: C24H29N5O6. Mole weight: 483.52. | |
| Pemetrexed Impurity D | An impurity of Pemetrexed which is used to treat mesothelioma in combination with another chemotherapy drug called cisplatin. Grades: > 95%. CAS No. 144051-68-3. Molecular formula: C25H28N6O9. Mole weight: 556.54. | |
| Pemetrexed Impurity E Disodium Salt | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: (2R)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid sodium. Grades: >95%. CAS No. 937370-10-0. Molecular formula: C20H19N5Na2O6. Mole weight: 471.38. | |
| Pemetrexed L-Glutamyl-L-glutamic Acid | Pemetrexed L-Glutamyl-L-glutamic Acid is used in the synthesis of Pemetrexed, which is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC). Synonyms: Pemetrexed α-Dipeptide Impurity; Pemetrexed Impurity 22; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-α-glutamyl-; N-{4-[2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-α-glutamyl-L-glutamic acid. Grades: ≥95%. CAS No. 883553-87-5. Molecular formula: C25H28N6O9. Mole weight: 556.52. | |
| Penethacillin hydroiodide | Penethacillin is a prodrug of Benzylpenicillin, an antimicrobial agent used for the treatment of bovine mastitis. Synonyms: Benzylpenicillin Diethylaminoethyl Ester Hydroiodide; Diethyl (2- (6- (2-phenylacetamido) penicillanoyloxy) ethyl) ammonium iodide. Grades: > 95%. CAS No. 808-71-9. Molecular formula: C22H32IN3O4S. Mole weight: 561.48. | |
| Penicillanic Acid Sodium Salt | An impurity of Sulbactam. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic. Synonyms: Sulbactam Impurity 2 Sodium Salt. CAS No. 4027-62-7. Molecular formula: C8H10NO3S.Na. Mole weight: 223.23. | |
| Penicillanyl ampicillinamide | An impurity of Ampicillin, an antibiotic used for the treatment of various bacterial infections. Synonyms: (2S,5R,6R)-6-{(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Molecular formula: C24H29N5O6S2. Mole weight: 547.65. | |
| Penicillenic Acid | Penicillenic Acid is an impurity of Penicillin, which is a β-lactam antibiotic used as an antibacterial agent. Synonyms: 3-mercapto-3-methyl-2-(((5-oxooxazol-4(5H)-ylidene)methyl)amino)butanoic acid; 3-Mercapto-N-[(5-oxo-2-oxazolin-4-ylidene)methyl]-valine; Valine, 3-mercapto-N-((5-oxo-4(5H)-oxazolylidene)methyl)-; 3-Mercapto-N-[(5-oxo-4(5H)-oxazolylidene)methyl]valine; Valine, 3-mercapto-N-[(5-oxo-2-oxazolin-4-ylidene)methyl]-. Grades: ≥95%. CAS No. 10250-99-4. Molecular formula: C9H12N2O4S. Mole weight: 244.27. | |
| Penicillin amidase | Penicillin amidase is an enzyme used commercially for the production of semisynthetic penicillins. Synonyms: Amidase, penicillin; E.C. 3.5.1.11; Penicillin acylase; Benzylpenicillin acylase; Penicillin V acylase; Acylase, penicillin; Penicillin amidohydrolase; Penicillin G acylase. Grades: Activity wet form: 160U/g; Water content: 45%~60%. CAS No. 9014-6-6. | |
| Penta-O-acetyl Iopamidol | Penta-O-acetyl Iopamidol is used to protect Iopamidol, which is a nonionic radiocontrast medium used as a diagnostic aid (radiopaque medium). Uses: Protected iopamidol. Synonyms: Penta-O-acetyliopamidol; N1,N3-Bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-5-[[(2S)-2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxamide. Grades: ≥95%. CAS No. 289890-55-7. Molecular formula: C27H32I3N3O13. Mole weight: 987.27. | |
| PEPA | 2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats. Synonyms: 2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide. Grades: >98%. CAS No. 141286-78-4. Molecular formula: C16H16F2N2O4S2. Mole weight: 402.44. | |
| Peptide YY (3-36) | Peptide YY (3-36) is a Y2/Y5 Neuropeptide Y receptor agonist (IC50= 0.11 nM for inhibition of 125I-PYY binding to Y2 receptor). Human peptide YY (PYY) has roles in energy homeostasis, food ingestion, gut motility and insulin secretion. Synonyms: Peptide YY (PYY) (3-36), human; H-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2; L-alanyl-L-lysyl-L-prolyl-L-alpha-glutamyl-L-alanyl-L-prolyl-glycyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-seryl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-leucyl-L-asparagyl-L-leucyl-L-valyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide; PYY (3-36) (canine, mouse, porcine, rat). Grades: 98%. CAS No. 126339-09-1. Molecular formula: C176H272N52O54. Mole weight: 3980.42. | |
| Peracetyl Empagliflozin | Peracetyl Empagliflozin is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate; (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol Tetraacetate. CAS No. 915095-99-7. Molecular formula: C31H35ClO11. Mole weight: 619.06. | |
| Peretinoin | Peretinoin, also known as NIK-333, orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Synonyms: Peretinoin; NIK-333; NIK 333; NIK333. Grades: 99.79%. CAS No. 81485-25-8. Molecular formula: C20H30O2. Mole weight: 302.458. | |
| Perifosine | Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Synonyms: KRX-0401; KRX 0401; KRX0401; NKA17; NSC639966; NSC 639966; NSC-639966; D 21266; D-21266; D21266; D-21266N; N-Dimethylpiperidinium-4-yl(octadecyl)phosphate; 1, 1-Dimethyl-4-[[ (octadecyloxy) hydroxyphosphoryl]oxy]piperidinium inner salt. Grades: >98%. CAS No. 157716-52-4. Molecular formula: C25H52NO4P. Mole weight: 461.668. | |
| Pexidartinib (PLX3397) | Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R with IC50 of 20 nM, Kit with IC50 of 10 nM, and Flt3 with IC50 160 nM. Phase 3, respectively. Synonyms: PLX3397; PLX-3397; PLX 3397; Pexidartinib. Grades: 98%. CAS No. 1029044-16-3. Molecular formula: C20H15ClF3N5. Mole weight: 417.81. | |
| Pexmetinib | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. It has potential antineoplastic, anti-inflammatory, and antiangiogenic activities. It inhibits other kinases including vascular endothelial growth factor receptor (VEGFR2) and Src tyrosine kinases. Synonyms: 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea; Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]-; N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]urea; ARRY 614; ARRY-614; ARRY614; N-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)-N'-[5-fluoro-2-[1-(2-hydroxyethyl)-1H-indazol-5-yloxy]benzyl]urea. Grades: 98%. CAS No. 945614-12-0. Molecular formula: C31H33FN6O3. Mole weight: 556.63. | |
| PF-04418948 | PF-04418948 is a potent and selective prostaglandin EP2 receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PGE2 on an EFS-induced contraction of the human myometrium, and antagonizes PGE2-induced relaxation of carbachol pre-contracted rings of mouse trachea. Synonyms: PF04418948; PF-04418948; PF 04418948; PF4418948; PF-4418948; PF 4418948. Grades: 98%. CAS No. 1078166-57-0. Molecular formula: C23H20FNO5. Mole weight: 409.41. | |
| PF-04691502 | PF-04691502 is an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. It inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Synonyms: PF04691502; PF 04691502; PF-04691502; PF4691502; PF 4691502; PF-4691502; 2-amino-8-((1R,4R)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: > 98%. CAS No. 1013101-36-4. Molecular formula: C22H27N5O4. Mole weight: 425.489. | |
| PF-04971729 | Cas No. 1210344-57-2. | |
| PF-06282999 | PF-06282999 is a selective myeloperoxidase Inhibitor originate by Pfizer. It showed good oral pharmacokinetics in preclinical species and robust irreversible inhibition of plasma MPO activity. In Mar 2015, Pfizer terminated phase I trial for the treatment of Acute coronary syndromes in Healthy volunteers in USA. Uses: Acute coronary syndromes. Synonyms: PF-06282999; PF06282999; PF06282999. 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide. Grades: 98%. CAS No. 1435467-37-0. Molecular formula: C13H12ClN3O3S. Mole weight: 325.77. | |
| PF 06409577 | PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively) for the potential treatment of diabetic nephropathy. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Synonyms: PF-06409577; PF06409577; PF-6409577; PF6409577; PF 6409577. Grades: ≥98% by HPLC. CAS No. 1467057-23-3. Molecular formula: C19H16ClNO3. Mole weight: 341.79. | |
| PF-06650833 | PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), which is an omnipresently expressed serine/threonine kinase involved in the regulation of innate immunity. PF-06650833 is useful for the treatment of autoimmune and inflammatory diseases associated with lnterleukin-1 Receptor Associated Kinase (IRAK) and more particularly modulates the function of IRAK. It is undergoing testing in a Phase II clinical study. Synonyms: zimlovisertib; PF 06650833; PF06650833. CAS No. 1817626-54-2. Molecular formula: C18H20FN3O4. Mole weight: 361.373. | |
| PF-1355 | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
| PF-431396 | PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Synonyms: PF-431396; PF 431396; PF431396. Grades: >98%. CAS No. 717906-29-1. Molecular formula: C22H21F3N6O3S. Mole weight: 506.5. | |
| PF-562271 | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Synonyms: PF-562271; PF 562271; PF562271. Grades: >98%. CAS No. 717907-75-0. Molecular formula: C21H20F3N7O3S. Mole weight: 507.49. | |
| PF-8380 | PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester. Grades: ≥95%. CAS No. 1144035-53-9. Molecular formula: C22H21Cl2N3O5. Mole weight: 478.33. | |
| PFI-3 | PFI-3, a potent and selective SMARCA2/4 bromodomain inhibitor, is a cell-permeable probe that binds avidly to the structurally-similar SMARCA4 bromodomain (Kd= 89 nM) and PB1(bromodomain 5) (Kd= 48 nM). Synonyms: PFI-3; PFI 3; PFI3. (E)-1-(2-hyd roxyphenyl)-3-[(1R,4R)-2-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-5-yl]prop-2-en-1-one; PF-06687252; PFI-3 compound; PF 06687252; PF06687252. Grades: >98%. CAS No. 1819363-80-8. Molecular formula: C19H19N3O2. Mole weight: 321.38. | |
| PFK15 | PFK15 is a potent and selective inhibitor of 6-phosphofructo-2-kinase (PFKFB3) with IC50 of 207 nM. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cells to survive in the harsh tumor microenvironment. Synonyms: PFK 015; PFK015; 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one. Grades: >98%. CAS No. 4382-63-2. Molecular formula: C17H12N2O. Mole weight: 260.29. | |
| Phenethicillin Sodium Salt | Phenethicillin is a semi-synthetic b-lactam penicillin antibiotic used to treat susceptible bacterial infections, usually Gram-positive bacteria. Synonyms: Phenoxy PC Sodium Salt; Phenoxyethylpenicillin Sodium Salt; Synthepen Sodium Salt; α-Phenoxyethylpenicillin Sodium Salt; 1-Phenoxyethylpenicillin Sodium Salt; Alfacilin Sodium Salt; Feneticillin Sodium Salt; NSC 117548 Sodium Salt; Optipen Sodium Salt; Penicillin 152 Sodium Salt; Penicillin MV Sodium Salt; Peniplus Sodium Salt; Penorale Sodium Salt; Penova Sodium Salt; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt. Grades: 95%. CAS No. 30302-52-4. Molecular formula: C17H19N2NaO5S. Mole weight: 386.40. | |
| Phenothiazine | Phenothiazine is an antibiotic with insecticidal, fungicidal, antibacterial, anthelmintic, antiemetic, antipsychotic, antihistaminic and anticholinergic activities. Phenothiazine is a dopamine-2 (D2) receptor antagonist and thus decreases the effect of dopamine in the brain. Uses: Employed in the preparation of carbazoles and piperazines, and charge-transfer semiconducting complexes. Synonyms: Contaverm; Danikoropa; Dibenzo-1,4-thiazine; Dibenzothiazine; Feeno; Fenoverm; NSC 2037; Nemazene; Nexarbol; Orimon; Padophene; Penthazine; Phenegic; Phenoverm; Phenovis; Phenoxur; Phenthiazine; Phenzeen; Reconox; Thiodiphenylamine; Promethazine EP Impurity A. Grades: ≥95%. CAS No. 92-84-2. Molecular formula: C12H9NS. Mole weight: 199.27. | |
| Phenoxymethylpenilloic Acid (Mixture of Diastereomers) | . Uses: A degradation product of penicillins. Synonyms: 5,5-Dimethyl-2-[[(2-phenoxyacetyl)amino]methyl]-4-thiazolidinecarboxylic Acid; Penilloic Acid V; Phenoxymethylpenicillosaeure; Phenoxymethyl-penilloinsaeure. Grades: 97%. CAS No. 4847-29-4. Molecular formula: C15H20N2O4S. Mole weight: 324.39. | |
| phensuximide | Phensuximide is an anticonvulsant drug. It can be used for the treatment of neurological disorders stemming from the brain. Phensuximide can suppress the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. Uses: Anticonvulsant. Synonyms: N-Methyl-2-phenyl-succinimide; (±)-Phensuximide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; 1-Methyl-3-phenylsuccinimide; Epimid; Lifene; Milontin; Milonton; Mirontin; N-Methyl-2-phenylsuccinimide; N-Methyl-3-phenylpyrrolidinedione; N-Methyl-3-phenylsuccinimide; N-Methyl-α-phenylsuccinimide; PM 334; Phensuximid; Phensuximide; RS-Phensuximide; Racemic Phensuximide; Succitimal. Grades: 95%. CAS No. 86-34-0. Molecular formula: C11H11NO2. Mole weight: 189.21. | |
| Phentolamine Mesylate | Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM. Uses: Adrenergic alpha-antagonists. Synonyms: Regitine; Vasomax®; 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol, monomethanesulfonate. Grades: >98%. CAS No. 65-28-1. Molecular formula: C17H19N3O·CH4O3S. Mole weight: 377.46. | |
| Phenyl-2-piperidylcarbinol | Synonyms: α-Phenyl-2-piperidinemethanol; 2-(α-Hydroxybenzyl)piperidine; NSC 15147; phenyl-2-piperidylmethan-1-ol. Grades: 98%. CAS No. 23702-98-9. Molecular formula: C12H17NO. Mole weight: 191.27. | |
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