BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Idrevloride | Idrevloride is an epithelial sodium channel (ENaC) inhibitor. Synonyms: 3,5-diamino-6-chloro-N-{[4-(4-{2-[(1-deoxy-D-glucitol-1-yl)(hexyl)amino]ethoxy}phenyl)butyl]carbamimidoyl} pyrazine-2-carboxamide; 3,5-diamino-6-chloro-N-[N'-[4-[4-[2-[hexyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]ethoxy]phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide. CAS No. 1416973-63-1. Molecular formula: C30H49ClN8O7. Mole weight: 669.22. |  |
| Iduronic acid | L-Iduronic acid is a crucial component in the biomedical industry used for various purposes. It is commonly employed in the synthesis of dermatan sulfate, a polysaccharide found in connective tissues. Additionally, L-Iduronic acid is utilized in the production of heparan sulfate, a glycosaminoglycan involved in different biological processes. Synonyms: d-iduronic acid; 3402-98-0; Iduronic acid, D-; (2S,3R,4R,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid; F5HD8XQ3DP; 8DWF4HK64B; 21675-53-6; UNII-F5HD8XQ3DP; UNII-8DWF4HK64B; IDURONIC ACID, DL-; SCHEMBL147158; DTXSID90187632; IAJILQKETJEXLJ-LECHCGJUSA-N; Q418846; W-202387. Grade: ≥95%. CAS No. 3402-98-0. Molecular formula: C6H10O7. Mole weight: 194.14. | |
| IDX184 | IDX184 is a potent and orally bioavailable HCV replication inhibitor that potently inhibits HCV polymerase with an IC50 of 0.31 μM and a Ki of 52.3 nM. Synonyms: Guanosine, 2'-C-methyl-, 5'-(2-((3-hydroxy-2,2-dimethyl-1-oxopropyl)thio)ethyl N-(phenylmethyl)phosphoramidate); 5'-O-[(Benzylamino)[2-(3-hydroxy-2,2-dimethylpropionylsulfanyl)ethoxy]phosphoryl]-2'-C-methylguanosine; 2'-C-Methylguanosine 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]. Grade: ≥95%. CAS No. 1036915-08-8. Molecular formula: C25H35N6O9PS. Mole weight: 626.62. | |
| IDX899 | IDX899 is a novel next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) with activity against efavirenz-resistant strains. It is used in the treatment of treatment-naive HIV-1-infected subjects. Uses: Idx899 is used in the treatment of treatment-naive hiv-1-infected subjects. Synonyms: GSK 224876 ; GSK-224876 ; GSK224876; IDX-899; IDX 899; IDX899; 5-Chloro-3-[[3-[(E)-2-cyanovinyl]-5-methyl-phenyl]-methoxy-phosphoryl]-1H-indole-2-carboxamide; Methyl (E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate; GSK-224876; GSK224876; (R,E)-methyl (2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate. Grade: 95%. CAS No. 1097733-15-7. Molecular formula: C20H17ClN3O3P. Mole weight: 413.79. | |
| IEM 1460 | IEM 1460, an adamantane derivative, is a selective and voltage-dependent open-channel antagonist of AMPA receptors. It is Ca2+ permeable and lacks GluR2 subunits. So it may be used to discriminat between AMPA receptors of different subunit composition. It selectively blocks fast spiking interneuron but not mediums spiny projection neuron in mouse striatum. It is used as an anticonvulsant in vivo. Synonyms: IEM 1460; IEM1460; IEM-1460; N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide. Grade: ≥98% by HPLC. CAS No. 121034-89-7. Molecular formula: C19H38N2Br2. Mole weight: 454.33. | |
| IEM 1754 dihydrobromide | IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. Synonyms: IEM-1754 dihydrobromide; IEM1754 dihydrobromide; IEM-1754 2HBr; IEM 1754 2HBr; IEM1754 2HBr; N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide. Grade: >98%. CAS No. 162831-31-4. Molecular formula: C16H32Br2N2. Mole weight: 412.25. | |
| IEM 1925 dihydrobromide | IEM 1925 dihydrobromide is the dihydrobromide salt of IEM 1925, which is a use- and voltage-dependent open-channel antagonist of AMPA receptors. It is selective between subtypes and blocks GluR2 subunit-lacking receptors more potently than GluR2-containing receptors and IEM 1754. It alleviates inflammatory pain in a rat model of peripheral inflammation. Synonyms: IEM 1925 dihydrobromide; IEM1925 dihydrobromide; IEM-1925 dihydrobromide; N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide. Grade: ≥98% by HPLC. CAS No. 258282-23-4. Molecular formula: C17H28N2.2HBr. Mole weight: 422.24. | |
| Ieramilimab | Ieramilimab is a humanized monoclonal antibody that binds to LAG-3. Ieramilimab has been investigated as a cancer therapy. Synonyms: LAG525; IMP701. CAS No. 2137049-37-5. | |
| Ifenprodil | Ifenprodil is an NMDA receptor antagonist and acts at the polyamine site. It is also an α2 adrenergic receptor ligand. It is selective for σ2 ligand over σ1 sites. It is used as a neuroprotective agent and peripheral vasodilator. Uses: Excitatory amino acid antagonists. Synonyms: 4-[2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl]phenol; (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol; α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol; 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine); 2-(4-Benzylpiperidino)-1-(1-hydroxyphenyl)-1-propanol; RC 61-91. Grade: ≥99% by HPLC. CAS No. 23210-56-2. Molecular formula: C21H27NO2. Mole weight: 325.44. | |
| Ifenprodil Tartrate | Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. Uses: Adrenergic alpha-antagonists. Synonyms: Ifenprodil (tartrate). Grade: >98%. CAS No. 23210-58-4. Molecular formula: 2(C21H27NO2).C4H6O6. Mole weight: 800.98. | |
| Ifetroban | Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials for the treatment of Asthma, Hepatorenal syndrome, Portal hypertension and Systemic scleroderma is on-going. Uses: Asthma; hepatorenal syndrome; portal hypertension; systemic scleroderma. Synonyms: Ifetroban; BMS 180291-02; BMS-180291; BMS180291; CHEMBL283100; BMS-180291; SCHEMBL9589119; 3-[2-[[3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]propanoic acid. Grade: 98%. CAS No. 143443-90-7. Molecular formula: C25H32N2O5. Mole weight: 440.54. | |
| Ifidancitinib | Ifidancitinib is a potent and selective JAK kinases 1/3 inhibitor for the research of allergies, asthma and autoimmune diseases. Synonyms: ATI-50002; ATI-502; 2(3H)-Benzoxazolone, 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methyl-4-pyrimidinyl)amino)-; 5-((2-((4-Fluoro-3-methoxy-5-methylphenyl)amino)-5-methyl-4-pyrimidinyl)amino)-2(3H)-benzoxazolone; 5-((2-(4-Fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-yl)amino)benzo(d)oxazol-2(3H)-one. CAS No. 1236667-40-5. Molecular formula: C20H18FN5O3. Mole weight: 395.39. | |
| IFNα | Recombinant human IFNα; A type I interferon consisting of 165 amino acid residues with lysine in position 23. It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences. | |
| IFN alpha-IFNAR-IN-1 | IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). It exerts immunosuppressive activity by the direct interaction with IFN-α. Uses: Ifn alpha-ifnar-in-1 inhibits mva-induced ifn-α responses by bm-pdcs. it exerts immunosuppressive activity by the direct interaction with ifn-α. Synonyms: IFN-alpha; IFN alpha; IFNAR-IN-1; IFNAR IN 1; IFNARIN1; IFNAR inhibitor 1; IFNAR-inhibitor-1; IFN-alpha and IFNAR interaction inhibitor. Grade: >98%. CAS No. 844882-93-5. Molecular formula: C18H17NS. Mole weight: 279.40. | |
| IFN alpha-IFNAR-IN-1 hydrochloride | IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptide, low-molecular-weight inhibitor. It inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3-L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM). Synonyms: IFN alpha-IFNAR-IN-1 (hydrochloride); IFN-α-IFNAR-IN-1 (hydrochloride). Grade: 98%. CAS No. 2070014-98-9. Molecular formula: C18H18ClNS. Mole weight: 315.86. | |
| Ifosfamide | Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. Uses: Antineoplastic agents, alkylating. Synonyms: 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide; (2-Chloro-ethyl)-[3-(2-chloro-ethyl)-2-oxo-2λ*5*-[1,3,2]oxazaphosphinan-2-yl]-amine; (±)-Ifosfamide; 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; A 4942; Asta Z 4942; Cyfos; Holoxan; Holoxan 1000; Ifex; Ifomide; Ifosfamid; Ifosfomide; Ifosphamide; Iphosphamide; Isoendoxan; Isofosfamide; Isophosphamide; Mitoxana; MJF 9325; Naxamide; NSC 109724; Z 4942. Grade: >98%. CAS No. 3778-73-2. Molecular formula: C7H15Cl2N2O2P. Mole weight: 261.09. | |
| Ifosfamide Impurity 1 | Ifosfamide Impurity 1. Grade: > 95%. Molecular formula: C8H17Cl2N2O2P. Mole weight: 275.12. | |
| Ifosfamide Impurity A | Ifosfamide Impurity A. Synonyms: 3-[(2-chloroethyl)amino]propyl dihydrogen phosphate. Grade: > 95%. CAS No. 22608-58-8. Molecular formula: C5H13ClNO4P. Mole weight: 217.59. | |
| Ifosfamide Impurity B | Ifosfamide Impurity B. Synonyms: Bis[3-[(2-chloroethyl)amino]propyl] dihydrogen diphosphate. Grade: > 95%. CAS No. 241482-18-8. Molecular formula: C10H24Cl2N2O7P2. Mole weight: 417.17. | |
| Ifosfamide Impurity E | Ifosfamide Impurity E. Synonyms: 3-chloro-N-(2-chloroethyl)propan-1-amine. Grade: > 95%. CAS No. 42453-19-0. Molecular formula: C5H11Cl2N. Mole weight: 156.06. | |
| Ifosfamide Impurity F | Ifosfamide Impurity F. Synonyms: Ifosfamide Impurity F; 81485-04-3. Grade: > 95%. CAS No. 81485-04-3. Molecular formula: C5H10Cl2NO2P. Mole weight: 218.02. | |
| iFSP1 | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2) with EC50 of 103 nM. iFSP1 sensitizes cancer cell lines from different origins to RSL3-induced ferroptosis Dose-dependent toxicity of RSL3 in a panel of human cancer cell lines from different origins treated with or without iFSP1 and Lip-1. Synonyms: 1-Amino-3-p-tolyl-benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile. CAS No. 150651-39-1. Molecular formula: C20H13N5. Mole weight: 323.35. | |
| IG-105 | IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC(50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways. Synonyms: IG105; IG 105. Grade: 98%. CAS No. 905978-63-4. Molecular formula: C20H19N3O4S. Mole weight: 397.45. | |
| Iganidipine | Iganidipine is a calcium channel blocker and optic nerve circulation vasodilator. Synonyms: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2,2-dimethyl-3-[4-(2-propenyl)-1-piperazinyl]propyl Methyl Ester 3,5-Pyridinedicarboxylic Acid; (±)-3-(4-Allyl-1-piperazinyl)-2,2-dimethylpropylmethyl-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2,2-dimethyl-3-[4-(2-propen-1-yl)-1-piperazinyl]propyl methyl ester. Grade: 95%. CAS No. 119687-33-1. Molecular formula: C28H38N4O6. Mole weight: 526.62. | |
| IGF-1 LR3 | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Synonyms: Long R3-IGF-1; IGF-1 Long R3; Long arginine 3-IGF-1. Grade: 95%. CAS No. 946870-92-4. Molecular formula: C400H625N111O115S9. Mole weight: 9117.6. | |
| IGF-1R inhibitor-2 | IGF-1R inhibitor-2 is an inhibitor of insulin-like growth factor-1 receptor (IGF-1R). Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis. Synonyms: 2-fluoro-6-((2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzamide. CAS No. 1116236-15-7. Molecular formula: C24H24FN7O2. Mole weight: 461.49. | |
| iGOT1-01 | iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1/GOT1) inhibitor with anticancer activity. Synonyms: 1-Piperazinecarboxamide, 4-(1H-indol-4-yl)-N-phenyl. Grade: >98%. CAS No. 882256-55-5. Molecular formula: C19H20N4O. Mole weight: 320.39. | |
| Igovomab | Igovomab is a mouse monoclonal antibody used as a diagnostic imaging agent for varian cancer research. Synonyms: Indimacis 125; Immunoglobulin G1, anti-(human CA 125 (carbohydrate antigen)) F(ab')2 fragment (mouse monoclonal OC125F(AB')2 γ1-chain), disulfide with mouse monoclonal OC125F(AB')2 light chain, dimer. Grade: 95%. CAS No. 171656-50-1. | |
| IGS-1.76 | IGS-1.76 is an inhibitor of the protein-protein interactions (PPI) that acts as a potential drug candidate for Fragile X syndrome pharmacotherapy. Synonyms: N-(benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide. Grade: 98% by HPLC. CAS No. 313480-47-6. Molecular formula: C22H18N2OS. Mole weight: 358.5. | |
| Iguratimod | Iguratimod is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Uses: Anti-inflammation agent. Synonyms: T 614; T-614; T614; N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide; Careram; Kolbet; UNII-4IHY34Y2NV. Grade: 0.98. CAS No. 123663-49-0. Molecular formula: C17H14N2O6S. Mole weight: 374.367. | |
| iHCK-37 | iHCK-37 is a new specific pharmacological hematopoietic cell kinase (HCK) inhibitor. HCK is one of Src kinase family (SFK) member. Synonyms: ASN05260065. Grade: 98%. CAS No. 516478-09-4. Molecular formula: C30H32N4O2S2. Mole weight: 544.73. | |
| IHMT-PI3Kδ-372 | IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research. Grade: 99%. CAS No. 2429889-62-1. Molecular formula: C26H23F2N7O2. Mole weight: 503.50. | |
| IHMT-PI3Kδ-372 S-isomer | An S isomer of IHMT-PI3Kδ-372, a potent and selective PI3Kδ inhibitor used for the treatment of chronic obstructive pulmonary disease. Synonyms: 2-[(1S)-1-[4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone. CAS No. 2429889-61-0. Molecular formula: C26H23F2N7O2. Mole weight: 503.5. | |
| IHR 1 | IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grade: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13. | |
| IHR-Cy3 | IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt. Grade: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64. | |
| IHVR-17028 | IHVR-17028, a potent and broad-spectrum antiviral drug used in infectious disease research, has antiviral activity against BVDV, TCRV and DENV with EC50s of 0.4, 0.26 and 0.3 μM, respectively. It is a potent inhibitor of ER α-glucosidase I with an IC50 of 0.24 μM. Synonyms: Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-; N-Cyclohexyl-2,2-dimethyl-N-{6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl}propanamide. Grade: ≥98% (HPLC). CAS No. 1428247-78-2. Molecular formula: C23H44N2O5. Mole weight: 428.61. | |
| II-B08 | This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grade: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61. | |
| IIIM-290 | IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1, respectively. Synonyms: 2-[(E)-2-(2,6-Dichlorophenyl)vinyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 2-[(E)-2-(2,6-dichlorophenyl)ethenyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-. Grade: ≥95%. CAS No. 2213468-64-3. Molecular formula: C23H21Cl2NO5. Mole weight: 462.32. | |
| IITZ-01 | IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51. | |
| IK1 inhibitor PA-6 | IK1 inhibitor PA-6 is a pentamidine analogue. It is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 has the potential to treat atrial fibrillation and arrhythmia. Synonyms: PA-6; 1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane; N,N'-((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))dibenzimidamide. Grade: 98%. CAS No. 500715-03-7. Molecular formula: C31H32N4O2. Mole weight: 492.61. | |
| IK-930 | IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44. | |
| Ikarisoside F | Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grade: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61. | |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. | |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grade: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is a potent and selective IκB kinase (IKK) inhibitor with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα, respectively. It inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Synonyms: N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride; [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone hydrochloride; Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1). Grade: 98%. CAS No. 1186195-62-9. Molecular formula: C28H30ClN5OS. Mole weight: 520.09. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grade: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grade: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-β. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grade: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grade: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| IKK-IN-1 | IKK-IN-1 is an IKK inhibitor. (Extracted from patent WO2002024679A1, compound example 18-13). Synonyms: 2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-(4-piperidinyl)-, hydrochloride (1:1); 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-5-(4-piperidinyl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride (1:1). Grade: ≥95%. CAS No. 406211-06-1. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| IKK-IN-3 | IKK-IN-3 is a potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ), with IC50s of 19 and 400 nM for IKKβ and IKKα, respectively. Synonyms: 1,2-Ethanediamine, N1-(8-methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-; N-(8-Methyl-2-phenylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-yl)-1,2-ethanediamine. CAS No. 615528-53-5. Molecular formula: C17H17N5S. Mole weight: 323.42. | |
| IKK-IN-4 | IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 (IKKβ or IKK2), with IC50s of 45 and 650 nM for IKKβ and IKKα, respectively. Synonyms: Imidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine, 2-[3-(2-aminoethyl)phenyl]-N,8-dimethyl-; 2-[3-(2-Aminoethyl)phenyl]-N,8-dimethylimidazo[1,2-a]thieno[3,2-e]pyrazin-5-amine. CAS No. 615529-94-7. Molecular formula: C18H19N5S. Mole weight: 337.44. | |
| IL-15-IN-1 | IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor that inhibits the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. Synonyms: Ethyl 3-[8-({4-methyl-5-[(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)octanamido]benzoate; Benzoic acid, 3-[[8-[[5-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methyl]-4-methyl-4H-1,2,4-triazol-3-yl]thio]-1-oxooctyl]amino]-, ethyl ester. Grade: ≥95%. CAS No. 1831830-20-6. Molecular formula: C30H36N6O4S. Mole weight: 576.71. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 is an antagonist of IL-17A, with a Kd of 0.66 μM and an IC50 of 1.14 μM. Synonyms: (S)-N-(1-((4-(2-(2-(1-(2-Amino-2-oxoethyl)cyclopentyl)-N,N-dimethylacetamido)ethyl)phenyl)amino)-3-(2-fluorophenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide; N-(4-{2-[({1-[2-(Dimethylamino)-2-oxoethyl]cyclopentyl}acetyl)amino]ethyl}phenyl)-2-fluoro-Nα-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-L-phenylalaninamide; 1,1-Cyclopentanediacetamide, N1-[2-[4-[[(2S)-3-(2-fluorophenyl)-2-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1-oxopropyl]amino]phenyl]ethyl]-N1,N1-dimethyl-. Grade: ≥95%. CAS No. 2205034-18-8. Molecular formula: C33H41FN6O4. Mole weight: 604.71. | |
| IL-17A antagonist 3 | IL-17A antagonist 3 is an antagonist of IL-17A. Synonyms: (4S,20R)-7-Chloro-N-methyl-4-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3,18-dioxo-2,19-diazatetracyclo[20.2.2.16,10.111,15]octacosa-1(24),6(28),7,9,11(27),12,14,22,25-nonaene-20-carboxamide; 2,19-Diazatetracyclo[20.2.2.16,10.111,15]octacosa-6,8,10(28),11,13,15(27),22,24,25-nonaene-20-carboxamide, 7-chloro-N-methyl-4-[[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino]-3,18-dioxo-, (4S,20R)-. Grade: ≥95%. CAS No. 2230780-65-9. Molecular formula: C33H33ClN6O4. Mole weight: 613.11. | |
| IL-17A inhibitor 1 | IL-17A inhibitor 1 is an inhibitor of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-; N-[(S)-(4,4-Difluorocyclohexyl)(7-{(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl}imidazo[1,2-b]pyridazin-2-yl)methyl]-4-methyl-1,2,5-oxadiazole-3-carboxamide. Grade: ≥95%. CAS No. 2452464-73-0. Molecular formula: C24H27F5N8O4. Mole weight: 586.51. | |
| IL-17A inhibitor 2 | IL-17A inhibitor 2, an IL-17A inhibitor, is used to treat psoriasis, rheumatoid arthritis and multiple sclerosis. Synonyms: 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-(difluoromethyl)-; N-((S)-(4,4-difluorocyclohexyl)(7-((S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)methyl)-4-(difluoromethyl)-1,2,5-oxadiazole-3-carboxamide. CAS No. 2452464-77-4. Molecular formula: C24H25F7N8O4. Mole weight: 622.50. | |
| IL-17A modulator-1 | IL-17A modulator-1 is an IL-17A modulator that can be used to study diseases or disorders associated with the modulation of IL-17A activity, including diseases with immune component or autoimmune pathol, cancer and neurodegenerative disorders. It inhibits the biological effects of IL-17A with a pIC50 of 8.2. (Extracted from patent WO2021239743+A1, example 9). Synonyms: (S)-N-(1-((4-(3,5-dimethoxypyridin-4-yl)phenyl)amino)-1-oxo-3,3-diphenylpropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. CAS No. 2748749-29-1. Molecular formula: C33H31N5O4. Mole weight: 561.63. | |
| IL-17A modulator-2 | IL-17A modulator-2 is an IL-17A modulator that can be used to study diseases or disorders associated with the modulation of IL-17A activity, including diseases with immune component or autoimmune pathol, cancer and neurodegenerative disorders. It inhibits the biological effects of IL-17A with a pIC50 of 8.3. (Extracted from patent WO2021239743+A1, example 27). Synonyms: (S)-N-(1-((4-(1-hydroxy-3,5-dimethoxypyridin-4(1H)-ylidene)cyclohexa-2,5-dien-1-ylidene)amino)-1-oxo-3,3-diphenylpropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2748749-47-3. Molecular formula: C33H31N5O5. Mole weight: 577.63. | |
| IL-17 modulator 1 | IL-17 modulator 1 is an orally active and highly effective IL-17 modulator, which can be used in the study to prevent, treat or improve a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis. (Extracted from patent WO 2020127685). Synonyms: (S)-(4-(4-(3,3-dicyclopropyl-2-(1-isopropyl-1H-pyrazole-5-carboxamido)propanamido)phenyl)-3,5-dimethyl-1H-pyrazol-1-yl)methyl dihydrogen phosphate. CAS No. 2446803-85-4. Molecular formula: C28H37N6O6P. Mole weight: 584.60. | |
| IL-17 modulator 1 disodium | IL-17 modulator 1 disodium is an orally active and highly effective IL-17 modulator, which can be used in the study to prevent, treat or improve a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis. (Extracted from patent WO 2020127685). Synonyms: sodium (S)-(4-(4-(3,3-dicyclopropyl-2-(1-isopropyl-1H-pyrazole-5-carboxamido)propanamido)phenyl)-3,5-dimethyl-1H-pyrazol-1-yl)methyl phosphate. CAS No. 2446803-91-2. Molecular formula: C28H35N6Na2O6P. Mole weight: 628.57. | |
| IL-17 modulator 3 | IL-17 modulator 3 is an IL-17 modulator used in the study of inflammation, cancer and autoimmune diseases. (Extracted from patent US20200247785A1). Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-1-cycloheptyl-2-[[4-[(2R)-3-(4-methyl-1-piperazinyl)-3-oxo-2-[(1-oxopropyl)amino]propyl]phenyl]amino]-2-oxoethyl]-1-methyl-; N-((S)-1-cycloheptyl-2-((4-((R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-propionamidopropyl)phenyl)amino)-2-oxoethyl)-1-methyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2467731-88-8. Molecular formula: C31H45N7O4. Mole weight: 579.73. | |
| IL-17 modulator 4 | IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which is an orally active and highly effective IL-17 modulator. Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)-; (S)-N-(1,1-dicyclopropyl-3-((4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-3-oxopropan-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide. Grade: ≥95%. CAS No. 2446803-65-0. Molecular formula: C27H34N6O2. Mole weight: 474.60. | |
| IL-17 modulator 4 sulfate | IL-17 modulator 4 sulfate is a prodrug of IL-17 modulator 1, which is an orally active and highly effective IL-17 modulator. Synonyms: 1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)-, compd. with sulfurate (3:2); (S)-N-(1,1-dicyclopropyl-3-((4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)-3-oxopropan-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide sulfate (3:2). CAS No. 2446806-90-0. Molecular formula: C27H34N6O2.(2/3H2SO4). Mole weight: 539.99. | |
| IL-17 modulator 5 | IL-17 modulator 5 is an inhibitor of IL-17, with an IC50 of 1 nM. Synonyms: N-((S)-(5-((S)-1-(6-cyano-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-3,3,3-trifluoropropyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)(4,4-difluorocyclohexyl)methyl)-4-methyl-1,2,5-oxadiazole-3-carboxamide. CAS No. 2724206-27-1. Molecular formula: C28H23F6N9O2. Mole weight: 631.53. | |
| IL-1R Antagonist | IL-1R antagonist is an interleukin-1 receptor homology and a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88), modulating the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mice with deep partial-thickness scald wound, IL-1R antagonist decreases the expression of inflammation related factors IL-1β and TNF-α and fibrosis related factors TGF-β1, MMP-1, CTGF, and type 1 collagen, promoting wound healing and ruducing fibrosis degree. Synonyms: Hydrocinnamoyl-L-valyl Pyrrolidine; N-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide. Grade: ≥98%. CAS No. 566914-00-9. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| IL2 | Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5. | |
| IL-4-inhibitor-1 | IL-4-inhibitor-1 is an IL-4 inhibitor with an EC50 of 1.81 μM. It is selective for IL-4 over IL-13 (EC50 = 18.2 μM). It inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50 = 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. Synonyms: 2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile; 3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-; 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-3-pyridinecarbonitrile. Grade: ≥95%. CAS No. 1332184-63-0. Molecular formula: C18H12FN3O2. Mole weight: 321.31. | |
| Ilaprazole Impurity 1 | Ilaprazole Impurity 1. Grade: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
| Ilaprazole Impurity 10 | Ilaprazole Impurity 10. Grade: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
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