BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Warfarin sodium | Warfarin is an anticoagulant applicated in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body. Warfarin was approved for use as a medication in 1954, and has remained popular ever since. Uses: Thromboembolism. Synonyms: Aldocumar; Athrombin; Coumadan Sodico; Coumadin; Coumadin Sodium; Coumadine; Coumafene Sodium; Dimantil; Farin; Marevam; Marevan; Orfarin; Panwarfin; Prothromadin; Ratsul Soluble ;Simarc 2 ; Sodium coumadin; Sodium Warfarin; [[2-Oxo-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-4-yl]oxy]-sodium; Sofarin; Taro-warfarin; Tintorane; UniWarfin; Varfine; Waran; Warfarin sodium; Warfarin Sodium Salt; Warfarina; Warfil 5; Warfilone; Zoocoumarin Sodium Salt;3-(α-Acetonylbenzyl)-4-hydroxycoumarin sodium salt. Grades: >98.0%. CAS No. 129-06-6. Molecular formula: C19H15NaO4. Mole weight: 330.31. |  |
| Way 100252 | When tested against a number of release-inducing stimuli, this active molecular can inhibit evoked [3H]GABA release. Synonyms: Way-100252; Way100252; Way 100252; 4-(bis(naphthalen-1-ylmethyl)amino)butanoic acid. Grades: 98%. CAS No. 129041-16-3. Molecular formula: C26H25NO2. Mole weight: 383.49. | |
| WAY 127039-A-1 sodium salt | WAY 127039-A-1 sodium salt is a metabolite of Bromfenac, a nonsteroidal anti-inflammatory drug (NSAID). Synonyms: 2-Amino-3-(4-bromobenzoyl)phenyloxoacetic acid. Grades: >95%. CAS No. 1391052-54-2. Molecular formula: C15H9BrNNaO4. Mole weight: 370.13. | |
| WAY 267464 dihydrochloride | WAY 267464 dihydrochloride is a potent and selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR), displaying anxiolytic-like effects. WAY 267464 may be beneficial for the treatment of psychosis and schizophrenia. Synonyms: WAY 267464 dihydrochloride; WAY267464 dihydrochloride; WAY-267464 dihydrochloride; N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-4-[(3,5-dihydroxyphenyl)methyl]-1-piperazinecarboxamide dihydrochloride. Grades: ≥97% by HPLC. CAS No. 1432043-31-6. Molecular formula: C32H35N7O4.2HCl. Mole weight: 654.59. | |
| WAY-316606 | WAY-316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-related disorders. WAY-316606 bound to sFRP-1 with a Kd of 0.08 mM and inhibited it with an EC50 of 0.65 mM. Synonyms: WAY 316606; 5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide. Grades: >98%. CAS No. 915759-45-4. Molecular formula: C18H19F3N2O4S2. Mole weight: 448.475. | |
| WAY 316606 hydrochloride | WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM). WAY 316606 hydrochloride stimulates the Wnt/β-catenin canonical signaling pathway and prevents sFRP-1 from interacting with Wnt signaling. Synonyms: WAY 316606 hydrochloride; WAY316606 hydrochloride; WAY-316606 hydrochloride; 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1781835-02-6. Molecular formula: C18H19F3N2O4S2.HCl. Mole weight: 484.94. | |
| Wilfordine | Wilfordine is an insecticidally active alkaloid found in the Tripterygium wilfordii Hook. f. Grades: >98%. CAS No. 37239-51-3. Molecular formula: C43H49NO19. Mole weight: 883.853. | |
| Wilfornine A | Wilfornine A is a natural compound of the sesquiterpenoid class found in the roots of Tripterygium wilfordii Hook. f. Grades: >98%. CAS No. 345954-00-9. Molecular formula: C45H51NO20. Mole weight: 925.89. | |
| Wilfortrine | Wilfortrine is a natural compound of the sesquiterpenoid class found in the roots of Tripterygium wilfordii Hook. f. Wilfortrine exhibits an inhibitory effect on liver cancer cell proliferation. Synonyms: Evonimine, 8-(acetyloxy)-O(sup 2)-deacetyl-8-deoxo-O(sup 2)-(3-furanylcarbonyl)-26-hydroxy-, (8-alpha)-. Grades: >98%. CAS No. 37239-48-8. Molecular formula: C41H47NO20. Mole weight: 873.814. | |
| Wiskostatin | Wiskostatin is a cell-permeable and selective inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP). Wiskostatin directly interacts with the regulatory GTPase-binding domain of N-WASP and inhibits its activation. Wiskostatin blocks the activation of Arp2/3 complex and inhibits actin polymerization. Synonyms: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol; 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol. Grades: ≥99% by HPLC. CAS No. 253449-04-6. Molecular formula: C17H18Br2N2O. Mole weight: 426.15. | |
| WL 47 - dimer | WL 47 - dimer acts as a high affinity caveolin-1 (CAV1) ligand (Kd = 23 nM) to disrupt the formation of caveolin-1 oligomers. It has selectivity for CAV1 over BSA, casein and HEWL. Synonyms: WL 47 - dimer; WL47 - dimer; WL-47 - dimer. Molecular formula: C80H130N24O18S4. Mole weight: 1844.3. | |
| WM-1119 | WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Synonyms: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide. CAS No. 2055397-28-7. Molecular formula: C18H13F2N3O3S. Mole weight: 389.38. | |
| WNK463 | WNK463 is a pan-WNK-kinase catalytic activity inhibitor. Synonyms: WNK-463; WNK 463; N-Tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide. CAS No. 2012607-27-9. Molecular formula: C21H24F3N7O2. Mole weight: 463.46. | |
| Wnt-C59 | Wnt-C59 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It was shown to arrest stemness and suppress growth of nasopharyngeal carcinoma in mice via Wnt pathway inhibition. Synonyms: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide. Grades: >98%. CAS No. 1243243-89-1. Molecular formula: C25H21N3O. Mole weight: 379.45. | |
| Wnt Inhibitor IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM. Uses: Differentiation. Synonyms: IWP 2, IWP-2, IWP2. Grades: 0.98. CAS No. 686770-61-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.592. | |
| WR 1065 | WR 1065 is a metabolite of Amifostine, and a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. WR 1065 activates p21waf-1 and MDM2 and inhibits DNA topoisomerase II&alpha. WR 1065 can induce cell cycle arrest and exert cytoprotective activity towards normal cells but not cancer cells in vivo. Synonyms: NSC345308; NSC 345308; NSC-345308; WR1065 Dihydrochloride; WR 1065 Dihydrochloride; WR-1065 Dihydrochloride; 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride; WR 1065 hydrochloride; Amifostine Thiol Dihydrochloride; WR-1065 dihydrochloride. CAS No. 14653-77-1. Molecular formula: C5H14N2S.2HCl. Mole weight: 207.16. | |
| WRR483 | WRR483 is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model. It is an analogue of K-11777. It demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. It also eradicates parasite infection in a mouse model of acute Chagas' disease. It binds covalently to the active site cysteine of the protease. It has potential to be developed as a treatment for Chagas disease. Uses: Wrr483 has potential to be developed as a treatment for chagas disease. Synonyms: WRR-483; WRR 483; WRR483. N-((S)-5-guanidino-1-oxo-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)pentan-2-yl)-4-methylpiperazine-1-carboxamide. Grades: >98%. CAS No. 1076088-50-0. Molecular formula: C29H41N7O4S. Mole weight: 583.75. | |
| WS6 | WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Synonyms: WS6; WS-6; WS 6. Grades: >98%. CAS No. 1421227-53-3. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
| WWL 113 | WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 = ~100 nM) with minimal activity against a panel of other serine hydrolases. WWL 113 was indicated ability to reduce weight gain in diet-induced obese mice and potentiate glucose tolerance in diabetic mice. It significantly reduces basal lipolysis in adipocytes. Synonyms: WWL113; WWL-113; WWL 113; 4'-[[[Methyl[[3- (4-pyridinyl) phenyl]methyl]amino]carbonyl]oxy]-[1, 1'-biphenyl]-4-carboxylic acid ethyl ester. Grades: ≥99% by HPLC. CAS No. 947669-86-5. Molecular formula: C29H26N2O4. Mole weight: 466.53. | |
| WWL123 | WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 μM) exhibiting >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases. WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington's disease as well as in chemically-induced epilepsy models. Synonyms: [3-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate. Grades: ≥95%. CAS No. 1338575-41-9. Molecular formula: C28H24N2O3. Mole weight: 436.5. | |
| WWL 123 | WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM) with antiepileptic activity. It suppresses PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Synonyms: WWL123; WWL-123; WWL 123; N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester. Grades: ≥98% by HPLC. CAS No. 1338574-83-6. Molecular formula: C28H24N2O3. Mole weight: 436.5. | |
| WWL229 | WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3). It inhibits the triglyceride hydrolase activity of Ces3, promotes lipid storage in cultured adipocytes and prevents basal lipolysis. Synonyms: (4-Nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1338575-28-2. Molecular formula: C16H22N2O5. Mole weight: 322.4. | |
| WWL70 | WWL70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM). ABHD6 is a serine hydrolase that is highly expressed in mammalian brain. Synonyms: 4'-carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate; WWL 70; WWL70; WWL-70. CAS No. 947669-91-2. Molecular formula: C27H23N3O3. Mole weight: 437.5. | |
| Xanthoangelol | Xanthoangelol is a chalcone isolated from Ashitaba with anti-inflammatory, anti-platelet and antibacterial activities. Uses: Proton pump inhibitors. Synonyms: Xanthoangelol; 62949-76-2; (E)-1-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; UNII-91D4GN26Z1MLS000574837. Grades: 98%. CAS No. 62949-76-2. Molecular formula: C25H28O4. Mole weight: 392.5. | |
| Xanthomicrol | Xanthomicrol is a flavonoid lipid isolated from Dracocephalum kotschyii leaf extract, and exhibits antineoplastic activity. Synonyms: 4',5-dihydroxy-6,7,8-trimethoxyflavone. CAS No. 16545-23-6. Molecular formula: C18H16O7. Mole weight: 344.3. | |
| XAV939 | XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It also suppresses proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Uses: Differentiation. Synonyms: XAV939; XAV 939; XAV-939. 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one. Grades: 0.98. CAS No. 284028-89-3. Molecular formula: C14H11F3N2OS. Mole weight: 312.31. | |
| XCT 0315908 | XCT 0315908, a RXR agonist, showed selectivity for RXR-Nurr1 over a broad range of other RXR dimerization partners but with rather low potency. Uses: A rxr agonist. Synonyms: XCT0135908; XCT-0135908; XCT 0135908. 4-[(5-Allyl-6-methyl-2-phenyl-4-pyrimidinyl)amino]benzoic acid; 4-[(5-Allyl-6-methyl-2-phenyl-4-pyrimidinyl)amino]benzoic acid. Grades: ≥96%. CAS No. 300837-31-4. Molecular formula: C21H19N3O2. Mole weight: 345.39. | |
| XE 991 | XE 991 is a KCNQ channel and M-current blocker potentially for the treatment of AD. Uses: Potential treatment of ad. Synonyms: XE-991; LS-190926; XE 991; LS 190926; XE991; LS190926; 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one. Grades: 99%. CAS No. 122955-42-4. Molecular formula: C26H20N2O. Mole weight: 376.45. | |
| XEN445 | XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM. Synonyms: XEN445; XEN 445; XEN-445. Grades: >98%. CAS No. 1515856-92-4. Molecular formula: C18H17F3N2O3. Mole weight: 366.33. | |
| Xenin 8 | Xenin 8, a C-terminal fragment of xenin, can modulate pancreatic insulin and glucagon secretion/effects. Xenin 8 stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Synonyms: Xenopsin-related peptide 1; XP-1. CAS No. 117442-28-1. Molecular formula: C51H79N15O9. Mole weight: 1046.28. | |
| (-)-Xestospongin C | (-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-induced Ca2+ release in PC12 cells and attenuate PHP-induced IL-2 production in Jurkat T cells, but exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Synonyms: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine; Xestospongin C. CAS No. 88903-69-9. Molecular formula: C28H50N2O2. Mole weight: 446.71. | |
| XMD16-5 | XMD16-5is a novel non-receptor tyrosine kinase TNK2 inhibitor (IC50 = 16 nM and 77 nM for D163E and R806Q mutant TNK2, respectively). Synonyms: 2-[4-(4-hydroxypiperidin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one; XMD-16-5; XMD 16-5; XMD165; XMD-165; XMD 165. CAS No. 1345098-78-3. Molecular formula: C23H24N6O2. Mole weight: 416.48. | |
| Y-27632 2HCl | Y-27632 is a Rho-associated kinase (ROCK) inhibitor. Y-27632 enhances the survival rate of human embryonic stem (hES) cells and promotes hESC differentiation into cortical and basal telencephalic progenitors. Synonyms: Y-27632 dihydrochloride; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride. Grades: >98%. CAS No. 129830-38-2. Molecular formula: C14H21N3O.2HCl. Mole weight: 320.26. | |
| Y-29794 Tosylate | Y-29794 is an orally active, potent and specific non-peptide inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Synonyms: (2-((8-(Dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate; Y29794 tosylate; Y 29794 tosylate; Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, 4-methylbenzenesulfonate (1:1); Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, mono(4-methylbenzenesulfonate); 2-[(8-Dimethylaminooctyl)thio]-3-(2-thenoyl)-6-isopropylpyridine p-toluenesulfonate. Grades: ≥95%. CAS No. 143984-17-2. Molecular formula: C30H42N2O4S3. Mole weight: 590.86. | |
| Y320 | Y-320 is a new phenylpyrazoleanilide immunomodulator that inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Synonyms: Y-320; Y 320. Grades: 98%. CAS No. 288250-47-5. Molecular formula: C27H29ClN6O2. Mole weight: 505.01. | |
| Yangonin | Extract from Piper methysticum, enhancing the binding of bicuculline at the γ-amino butyric acid. Uses: Enhances the binding of bicuculline. Synonyms: 4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one; 4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone. Grades: ≥98%. CAS No. 500-62-9. Molecular formula: C15H14O4. Mole weight: 258.27. | |
| YAP-TEAD Inhibitor 1 | YAP-TEAD Inhibitor 1 is a potent inhibitor of YAP-TEAD interaction with IC50 value of 25 nM. Synonyms: YAP-TEAD-IN-1; YAP-TEAD (Peptide 17). Grades: 98%. CAS No. 1659305-78-8. Molecular formula: C93H144ClN23O21S2. Mole weight: 2019.86. | |
| YE 120 | YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays), and also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). Synonyms: YE 120; YE120; YE-120; 2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile. Grades: ≥98% by HPLC. CAS No. 383124-82-1. Molecular formula: C16H9Cl2N3O. Mole weight: 330.17. | |
| YK-4-279 | YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. Synonyms: YK-4-279; YK4-279; YK 4-279; YK-4279; YK4279; YK 4279. Grades: >98%. CAS No. 1037184-44-3. Molecular formula: C17H13Cl2NO4. Mole weight: 366.20. | |
| YL-109 | Mice treated with vehicle showed significantly enlarged tumors, whereas mice treated with YL-109 showed attenuated tumor growth using MCF-7 cells. Interestingly, YL-109 also suppressed tumor growth in mice injected with MDA-MB-231 cells. Compared with the vehicle control, YL-109 significantly reduced lung metastasis. Synonyms: YL-109; YP109; YP 109. Grades: >98%. CAS No. 36341-25-0. Molecular formula: C14H11NO2S. Mole weight: 257.31. | |
| YM-155 hydrochloride | YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM. Synonyms: YM155 hydrochloride; YM 155 hydrochloride. Grades: >98%. CAS No. 355406-09-6. Molecular formula: C20H19ClN4O3. Mole weight: 398.84. | |
| YM-201636 | YM201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, can halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase. Synonyms: YM 201636; YM201636. Grades: >98%. CAS No. 371942-69-7. Molecular formula: C25H21N7O3. Mole weight: 467.48. | |
| YM-53601 | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. | |
| YM 750 | YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM), displaying hypocholesterolaemic and antiatherosclerotic activity in vivo. Synonyms: YM 750; YM750; YM-750; N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea; ACAT inhibitors, Yamanouchi. Grades: ≥98% by HPLC. CAS No. 138046-43-2. Molecular formula: C31H36N2O. Mole weight: 452.63. | |
| YM758 | YM758 is a novel 'funny' If current channel (If channel) inhibitor which has a specific bradycardiac effect, and it is under development for the treatment of stable angina and atrial fibrillation. Synonyms: N-[2-[(3R)-3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]ethyl]-4-fluorobenzamide; YM 758; YM-758; YM758 cpd. CAS No. 312752-85-5. Molecular formula: C26H32FN3O4. Mole weight: 469.55. | |
| YM 976 | YM 976 is an orally bioactive PDE4 inhibitor (IC50 = 2.2 nM). YM 976 inhibits PDE4 to maintain cAMP and prolong signal transduction. Synonyms: YM976; YM 976; YM-976. 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one. Grades: ≥98% by HPLC. CAS No. 191219-80-4. Molecular formula: C17H16ClN3O. Mole weight: 313.79. | |
| YMU1 | YMU1 is a human thymidylate kinase (hTMPK; IC50 value 1.65 μM) inhibitor yet not has inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Synonyms: ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate. Grades: 99%. CAS No. 902589-96-2. Molecular formula: C17H22N4O4S. Mole weight: 378.45. | |
| YS-49 | Anti-inflammatory agent; Antithrombotic; Antiplatelet; YS-49 protects cells from oxidant injury; induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury; activator of PI3K/Akt signaling. Synonyms: YS 49; YS49. Grades: >98%. CAS No. 132836-42-1. Molecular formula: C20H20BrNO2. Mole weight: 386.28. | |
| YW3-56 hydrochloride | YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 with IC50 values of 0.5-1 and 1-5 μM, respectively. It inhibits the growth of U2OS osteosarcoma cells with IC50 value of 2.5 μM in a p53-dependent manner. Synonyms: N-[(2S)-5-[(1-Amino-2-chloroethylidene)amino]-1-(benzylamino)-1-oxopentan-2-yl]-6-(dimethylamino)naphthalene-2-carboxamide hydrochloride. Grades: ≥80%. Molecular formula: C27H32ClN5O2·HCl. Mole weight: 530.49. | |
| YZ9 | YZ9 is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). YZ9 also competitively inhibits F-6-P (Ki = 0.094 μM), and suppresses cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay. Synonyms: YZ9; YZ 9; YZ-9; Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate; 7-Hydroxycoumarin-3-carboxylic acid ethyl ester; 3-carbethoxy-7-hydroxycoumarin. Grades: ≥98% by HPLC. CAS No. 6093-71-6. Molecular formula: C12H10O5. Mole weight: 234.2. | |
| (Z)-10-Tetradecenyl Acetate | The major sex pheromone of the oak leaf roller, Archips semiferanus Walker. Synonyms: (Z)-10-Tetradecen-1-ol Acetate; cis-10-Tetradecen-1-ol Acetate; cis-10-Tetradecenyl Acetate. CAS No. 35153-16-3. Molecular formula: C16H30O2. Mole weight: 254.41. | |
| (Z)-1-Bromooctadec-9-ene | (Z)-1-Bromooctadec-9-ene, an organic compound, plays a crucial role as an intermediate in synthesizing abundant biochemical, pharmaceutical and agrochemical substances. It occupies a significant position in the development of drugs for the treatment of diverse ailments, including inflammation and cancer. Moreover, it proves valuable in the creation of surfactants, polymers, and lubricants. Its multifaceted usage and potential make it a significant chemical of interest in numerous fields. Synonyms: Oleyl bromide; (Z)-1-Bromo-9-octadecene; (z)-9-octadecen; 9-octadecene, 1-bromo-, (Z)-; 1-bromo-cis-9-OCTADECENE; (9Z)-1-Bromo-9-octadecene; (Z)-9-Octadecen-1-yl bromide. CAS No. 6110-53-8. Molecular formula: C18H35Br. Mole weight: 331.3745. | |
| (Z)-2-decenoic acid | Microorganisms commonly accumulate at interfaces as part of biofilms held together by a matrix of hydrated extracellular polymeric substances. cis-2-Decenoic acid is an unsaturated short chain fatty acid that is secreted by P. aeruginosa and induces a dispersion response in biofilms formed by gram-negative and gram-positive bacteria, as well as by the yeast C. albicans. It effectively promotes dispersion of P. aeruginosa biofilms over a concentration range of 1.0 to 10 nM. Synonyms: cis-2-Decenoic acid. Grades: >98%. CAS No. 15790-91-7. Molecular formula: C10H18O2. Mole weight: 170.25. | |
| (Z)-5,5',6,6'-tetramethoxy-2,3-dihydro-[1,2'-biindenylidene]-1'(3'H)-one | An impurity of Donepezil, a medication for the treatment of Alzheimer's disease. CAS No. 36159-03-2. Molecular formula: C22H22O5. Mole weight: 366.41. | |
| (Z)-8-Dodecen-1-yl acetate | (Z)-8-Dodecen-1-yl acetate is a versatile organic compound, widely employed for its fragrance and flavor-enhancing properties in the food and beverage industry. Remarkably, this fascinating compound has also demonstrated intriguing pharmaceutical potential, with animal models revealing anti-inflammatory activities that could make it a promising candidate for future drug development. Synonyms: (Z)-8-Dodecen-1-yl acetate; Dodec-8-enyl acetate. Grades: 85%. CAS No. 28079-04-1. Molecular formula: C14H26O2. Mole weight: 226.36. | |
| (Z)-9-Tricosene | (9Z)-Tricosene is a pheromone released by insects, including D. melanogaster, M. domestica (house fly), and A. mellifera L. (honey bee). Synonyms: Muscalure; cis-9-Tricosene; cis-Tricos-9-ene; (9Z)-Tricosene; Flybait; Muscamone; (9Z)-tricos-9-ene. Grades: 90%. CAS No. 27519-02-4. Molecular formula: C23H46. Mole weight: 322.61. | |
| Zamicastat | Zamicastat is a potent and selective dopamine β-mono-oxygenase inhibitor. It prevents the Deterioration of Cardiometabolic and Inflammatory Biomarkers in a Genetic Model of Salt-sensitive Hypertension. It is used for the treatment for hypertension and heart failure. It was developed by Bial-Portela and in clinic phase 1 trails. Uses: Zamicastat is used for the treatment for hypertension and heart failure. Synonyms: 4-[2-(Benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione;(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione. Grades: >98%. CAS No. 1080028-80-3. Molecular formula: C21H21F2N3OS. Mole weight: 401.48. | |
| Zanamivir Amine | Zanamivir Amine is used as a precursor in the synthesis of Zanamivir. Synonyms: 4-α-Amino-N-acetyl-2-deoxy-2,3-didehydro-D-neuraminate; Zanamivir intermediates A. Grades: 95%. CAS No. 130525-62-1. Molecular formula: C11H18N2O7. Mole weight: 290.272. | |
| zapnometinib | zapnometinib is an ATP non-competitive MEK1/2 inhibitor that can treat respiratory viral infections by inhibiting MEK. Synonyms: Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-; ATR 002; PD 0184264. Grades: 99.63%. CAS No. 303175-44-2. Molecular formula: C13H7ClF2INO2. Mole weight: 409.55. | |
| Zardaverine | Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively. Uses: Bronchodilator agents. Synonyms: zardaverine; 101975-10-4; Zardaverine [INN]; Zardaverina; Zardaverinum; 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone; 6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE; TQ358GWH6Y; 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone; CHEMBL313842; DTXSID8042559; 6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one; CHEBI:46548; NCGC00016106-04; 3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one; CAS-101975-10-4; 3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- [CAS]; DTXCID6022559; 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one; 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone. Grades: >98%. CAS No. 101975-10-4. Molecular formula: C12H10F2N2O3. Mole weight: 268.22. | |
| Zastaprazan | Zastaprazan is a proton pump inhibitor. Synonyms: zastaprazanum. Grades: >98%. CAS No. 2133852-18-1. Molecular formula: C22H26N4O. Mole weight: 362.47. | |
| (Z)-Azoxystrobin | Azoxystrobin is a broad spectrum fungicide widely used in agriculture. Synonyms: (αZ)-2-[[6-(2-Cyanophenoxy)-4-pyrimidinyl]oxy]-α-(methoxymethylene)-benzeneacetic acid Methyl Ester; (Z)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-α-(methoxymethylene)-Benzeneacetic acid, Methyl Ester. Grades: > 95%. CAS No. 143130-94-3. Molecular formula: C22H17N3O5. Mole weight: 403.40. | |
| ZCL278 | ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase. It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 μM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF). Synonyms: ZCL-278; ZCL 278; ZCL278. CAS No. 587841-73-4. Molecular formula: C21H19BrClN5O4S2. Mole weight: 584.888. | |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK; benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Z-DEVD-fluoromethylketone. Grades: ≥95%. CAS No. 210344-95-9. Molecular formula: C30H41FN4O12. Mole weight: 668.67. | |
| Zectivimod | Zectivimod is an immunomodulator. Synonyms: zectivimodum. Grades: >98%. CAS No. 1623066-63-6. Molecular formula: C28H31Cl2N3O3. Mole weight: 528.47. | |
| (Z)-Famitinib | (Z)-Famitinib is a cutting-edge targeted kinase inhibitor taking center stage as a pioneering agent studying diverse forms of cancer. By methodically obstructing the function of prominent receptor tyrosine kinases like VEGFR, PDGFR and c-Kit, this novel inhibitor presents immense potentiality. Synonyms: 5-[2-(diethylamino)ethyl]-2-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-methyl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one; (Z)-2-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-5-(2-diethylaminoethyl)-3-methyl-1,5,6,7-tetrahydropyrrolo-[3,2-c]pyridin-4-one. Grades: ≥98%. CAS No. 1044040-56-3. Molecular formula: C23H27FN4O2. Mole weight: 410.48. | |
| ZGN-839 | ZGN-839 is a reversible methionine aminopeptidase 2 inhibitor developed by Zafgen that has the potential to treat nonalcoholic steatohepatitis (NASH). Uses: The potential treatment of nonalcoholic steatohepatitis (nash). Synonyms: ZGN-839; ZGN 839; ZGN839. | |
| Z-IETD-FMK | Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. Synonyms: caspase-8 inhibitor; Z-IE(OMe)TD(OMe)-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH2F; Z-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethylketone; N-benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone. Grades: ≥95%. CAS No. 210344-98-2. Molecular formula: C30H43FN4O11. Mole weight: 654.69. | |
| Ziftomenib | Ziftomenibum is an antineoplastic. Synonyms: KO539; KO-539; ziftomenibum. Grades: >98%. CAS No. 2134675-36-6. Molecular formula: C33H42F3N9O2S2. Mole weight: 717.87. | |
| ZINC69391 | ZINC69391 is a specific Rac1 inhibitor that interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. Synonyms: N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine; N-(4,6-Dimethyl-2-pyrimidinyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine. CAS No. 303094-67-9. Molecular formula: C14H14F3N5. Mole weight: 309.29. | |
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