BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| TX-1918 | TX-1918 is a cell-permeable inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K) with IC50 value of 440 nM. It also inhibits Src, PKA, PKC, and EGFR kinases at higher concentrations. Synonyms: 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione. Grades: ≥98%. CAS No. 503473-32-3. Molecular formula: C14H12O3. Mole weight: 228.2. |  |
| Tyloxapol | Tyloxapol, a nonionic liquid polymer, is a surfactant to aid liquefaction. Synonyms: ETHOXYLATED P-TERT-OCTYLPHENOL FORMALDEHYDE POLYMER;4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL POLYMER WITH FORMALDEHYDE AND OXIRANE;TYLOXAPOL;TRITON(R) WR-1339; 4- (1, 1, 3, 3-tetra methyl butyl) -phenopolymerwithformalde hydeandoxirane ; alevaire. Grades: 95%. CAS No. 25301-02-4. Molecular formula: C17H30O4 (monomer). Mole weight: 280.40 (monomer). | |
| Tyr0-C-Type Natriuretic Peptide (32-53) | Tyr0-C-Type Natriuretic Peptide (32-53), a peptide hormone, is a crucial regulator of the body's fluid and electrolyte balance. Studies have demonstrated its therapeutic potential in cardiovascular and renal diseases. It exerts its effects via the Natriuretic Peptide Receptor C, thus signifying it as a potential drug target for future development though much remains unknown about the precise mechanisms of its action. Synonyms: H-Tyr-Gly-Leu-Ser-Lys-Gly-Cys(1)-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys(1)-OH. Grades: 95%. CAS No. 142878-79-3. Molecular formula: C102H166N28O30S3. Mole weight: 2360.77. | |
| Tyroserleutide | Tyroserleutide is a tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation. Synonyms: Tyroserleutide; YSL; CMS 024. H-Tyr-Ser-Leu-OH; CMS024; CMS-024. CAS No. 138168-48-6. Molecular formula: C18H27N3O6. Mole weight: 381.43. | |
| Tyrphostin A1 | Tyrphostin A1, can be as a negative control for inhibition of EGFR (IC50 >1250 μM) and was shown to inhibit the tyrosine phosphorylation of IL-2 stimulated Tyk-2 in plemented with 20% LADMAC supernatant. Uses: Antineoplastic agents. Synonyms: Tyrphostin 1; Tyrphostin-1; Tyrphostin1; 2-[ (4-methoxyphenyl) methylidene]propanedinitrile (3, 4-dihydroxybenzylidene) malononitrile (3, 4-dihydroxyphenyl) methylene propanedinitrile3,4-dihydroxybenzylidenemalononitrileRG 50810; RG50810RG-50810tyrphostin 23tyrphostin A1tyrphostin A23tyrphostin AG18tyr. CAS No. 2826-26-8. Molecular formula: C11H8N2O. Mole weight: 184.197. | |
| U-44069 | U-44069 is a stable analog of the endoperoxide PGH2 and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in [Ca2+] with EC50 value of 1.8 nM. U-44069 has an EC50 value of 3 μM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively. Synonyms: U 44069; U44069; 9,11-dideoxy-9α,11α-epoxymethano PGF2α; 9,11-dideoxy-9α,11α-epoxymethano Prostaglandin F2α; 9,11-epoxymethano Prostaglandin H2. Grades: ≥98%. CAS No. 56985-32-1. Molecular formula: C21H34O4. Mole weight: 350.5. | |
| U 46619 | U 46619 is a PGH2 (TXA2) analog that is reported to be a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). U 46619 has been shown to stimulate TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. U 46619 also activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors. Synonyms: U46619, U-46619, U 46619; (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid. Grades: ≥98% by HPLC. CAS No. 56985-40-1. Molecular formula: C21H34O4. Mole weight: 350.5. | |
| U-51605 | U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2). U-51605 is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases, as well as a partial agonist at TP receptors. Synonyms: U 51605; U51605; 7-(6-Oct-1-enyl-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl)hept-5-enoic acid. Grades: ≥98%. CAS No. 64192-56-9. Molecular formula: C20H32N2O2. Mole weight: 332.5. | |
| U-73343 | U-73343 is a analog of U 73122, and can be used as a negative control for phospholipase C inhibition in mechanically stimulated and its neighboring cells. It can also be used for studying the role of phospholipase C signaling in modulating epithelial Na+ channel function in gerbil Reissner's membranes. Uses: A negative control for phospholipase c inhibition in mechanically stimulated and its neighboring cells;study the role of phospholipase c signaling in modulating epithelial na+ channel (enac) function in gerbil reissner's membranes. Synonyms: U73343, U-73343, U 73343; 1-[6-[[(17b)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione. Grades: >95 %. CAS No. 142878-12-4. Molecular formula: C29H42N2O3. Mole weight: 466.66. | |
| U-75875 | U-75875 is a protease inhibitor. It is also a peptidomimetic inhibitor and could inhibit HIV-1 gag-pol protein. It completely blocked HIV replication in human peripheral blood mononuclear cells and in a continuous cell line. It can be used as therapeutic potential of protease inhibitors for treatment of HIV infection. Uses: U-75875 could inhibit hiv-1 gag-pol protein. it can be used as therapeutic potential of protease inhibitors for treatment of hiv infection. Synonyms: U75875, U-75875, U 75875, Pnu-75875, Pnu 75875, Pnu75875; N-(1-Naphtyloxyacetyl)-L-His-[(2R,3R,4R,5S)-3,4-dihydroxy-2-isopropyl-5-(cyclohexylmethyl)-5-amino*pentanoyl]-L-Ile-(2-pyridylmethyl)NH2;PNU-75875;(2R,3R,4R,5S)-6-cyclohexyl-3,4-dihydroxy-5-[[(2S)-3-(1H-imidazol-5-yl)-2-[(2-naphthalen-1-yloxyacetyl)amino]propanoyl]amino]-N-[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]-2-propan-2-ylhexanamide;(2S,3S)-N-(4-(L-histidyl)-3-(5-amino-6-cyclohexyl-3,4-dihydroxy-2-isopropylhexanoyl)-5-(2-(naphthalen-1-yloxy)acetyl)pyridin-2-yl)-2-amino-3-methylpentanamide. Grades: >98%. CAS No. 112190-24-6. Molecular formula: C45H61N7O7. Mole weight: 812.02. | |
| UAMC00039 dihydrochloride | UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor (IC50 = 0.48 nM) with selectivity against DPP-9, DPP-8 and DPP-IV (IC50= 78.6, 142 and 165 μM, respectively). Synonyms: UAMC00039, UAMC 00039, UAMC-00039, UAMC 00039 dihydrochloride, UAMC 00039 2HCl; (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-one;dihydrochloride; N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine hydrochloride. CAS No. 697797-51-6. Molecular formula: C16H26Cl3N3O. Mole weight: 382.76. | |
| UAMC-3203 | UAMC-3203 is a ferroptosis inhibitor with IC50 value of 10 nM. Synonyms: UAMC 3203; UAMC3203; 3-(Benzylamino)-4-(cyclohexylamino)-N-(2-piperazin-1-ylethyl)benzenesulfonamide. CAS No. 2271358-64-4. Molecular formula: C25H37N5O2S. Mole weight: 471.66. | |
| UBP 296 | UBP 296 is a selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 1.09 μM) that displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. It has no activity at NMDA or group I mGlu receptors. UBP 296 was shown to selectively block kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Synonyms: UBP 296; UBP296; UBP-296; (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione; 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 745055-86-1. Molecular formula: C15H15N3O6. Mole weight: 333.3. | |
| UBP 301 | UBP 301 is a potent kainate receptor antagonist (apparent Kd = 5.94 μM), displaying ~ 30-fold selectivity over AMPA receptors. Synonyms: UBP 301; UBP301; UBP-301; (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid; 4-[[3-[(2S)-2-amino-2-carboxyethyl]-5-iodo-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 569371-10-4. Molecular formula: C15H14IN3O6. Mole weight: 459.2. | |
| UBP 302 | UBP 302 is a potent and selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM) that displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors. It has no activity at NMDA or group I mGlu receptors. UBP 302 was shown to block kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Synonyms: UBP302, UBP-302, UBP 302; (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione; 2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 745055-91-8. Molecular formula: C15H15N3O6. Mole weight: 333.3. | |
| UBP 310 | UBP 310 is a GLUK5 kainate receptor antagonist (IC50 = 130 nM), displaying 12,700-fold selectivity for GLUK5 over GLUK6. It has no activity at mGlu group I or NMDA receptors at concentrations of up to 10 μM. UBP 310 also blocks recombinant homomeric GLUK7 receptors. Synonyms: UBP310, UBP 310, UBP-310; (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione; 3-[[3-(2-amino-2-carboxyethyl)-5-methylidene-2,6-dioxopyrimidin-3-ium-1-yl]methyl]thiophene-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 902464-46-4. Molecular formula: C14H15N3O6S. Mole weight: 353.35. | |
| UCF 101 | UCF 101 is an Omi/HtrA2 protease inhibitor with IC50 value of 9.5 μM. Omi/HtrA2 is a mitochondria serine protease released in response to apoptotic stimuli. UCF 101 is naturally fluorescent enabling the visualization of its entry into cells. Synonyms: RT-014861; 5-({5-[2-(Dihydroxyamino)phenyl]furan-2-yl}methylidene)-1,3-diphenyl-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione. Grades: ≥98%. CAS No. 313649-08-0. Molecular formula: C27H17N3O5S. Mole weight: 495.5. | |
| UCM53 | UCM53 is an inhibitor of bacterial cell division that binds to the GTP site of the cell division protein FtsZ. It inhibits the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis. Synonyms: [4-(3-Chloro-4-hydroxybenzoyl)oxynaphthalen-2-yl] 3,4-dihydroxybenzoate. Grades: ≥98%. CAS No. 1449468-52-3. Molecular formula: C24H15ClO7. Mole weight: 450.8. | |
| UCPH 101 | UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 = 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3, respectively). UCPH 101 selectively inhibits anion currents in tsA201 cells expressing human EAAT1 (Kd = 0.34 μM) over rat EAAT4 and mouse EAAT5 at concentrations up to 10 μM. Synonyms: UCPH-101, UCPH 101, UCPH101; 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile. Grades: ≥98% by HPLC. CAS No. 1118460-77-7. Molecular formula: C27H22N2O3. Mole weight: 422.48. | |
| UDP-6-azido-6-deoxy-D-Gal | UDP-6-azido-6-deoxy-D-Gal, a nucleotide analog with great potential for studying glycosylation, has been employed in the synthesis of azido-sugars and labeling experiments to scrutinize the capabilities of glycosyltransferases. Its utility extends to probing the contribution of glycosylation in widespread pathological processes such as cancer and inflammation. This product can greatly benefit scientific research by providing precise and versatile tools to better understand glycosylation. Synonyms: Uridine 5'-(trihydrogen diphosphate), P'-(6-azido-6-deoxy-α-D-galactopyranosyl) ester. CAS No. 868208-96-2. Molecular formula: C15H23N5O16P2. Mole weight: 591.32. | |
| UDP-a-D-galactose | UDP-a-D-galactose is a pivotal nucleotide sugar molecule crucial for biosynthesizing carbohydrates and galactose-containing polysaccharides. Its active involvement in the biosynthesis of glycosphingolipids, the building blocks of cell membranes, makes it indispensable. Any impairment of this molecule might trigger galactosemia and other ailments, accentuating its contribution to cellular homeostasis. Synonyms: UDP-galactose; uridine diphosphate galactose; UDP-D-galactopyranose; Uridine pyrophosphogalactose; UDP-alpha-D-Galactose; Uridinediphosphogalactose; UDP-Gal; Uridine 5'-diphosphate galactose; Uridine 5'-(alpha-D-galactopyranosyl pyrophosphate); Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-galactopyranosyl ester; Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-galactopyranosyl ester. Grades: ≥95%. CAS No. 2956-16-3. Molecular formula: C15H24N2O17P2. Mole weight: 566.30. | |
| UDP-a-D-Xylose disodium | UDP-a-D-Xylose disodium is a remarkable biomedical compound for the research of specific ailments, displaying its functionality as an invaluable precursor for the intricate biosynthesis of glycoconjugates. By actively participating in the convoluted process of polysaccharide and proteoglycan formation within cellular entities, this indispensable compound assumes a fundamental role in the intricate metabolism of Xylose is a vital monosaccharide. Consequently, this extraordinary product finds extensive application within the realm of scientific investigation and therapeutic drug discovery, primarily focusing on the amelioration of intricacies linked to carbohydrate metabolism and glycosylation disorders. Synonyms: Uridine 5'-(trihydrogen diphosphate), P'-α-D-xylopyranosyl ester, disodium salt; UDP-Xyl 2Na. CAS No. 108320-89-4. Molecular formula: C14H22N2O16P2Na2. Mole weight: 582.26. | |
| Udp-beta-L-rhamnose | UDP-beta-L-rhamnose, an indispensable biomolecule extensively employed in the realm of biomedicine, assumes a pivotal stance in the intricate process of L-rhamnose biosynthesis. This saccharide, prevalent among diverse pharmaceutical agents and natural substances, acquires utmost significance in the advancement of therapeutics that aspire to combat bacterial infections, certain cancerous manifestations, and afflictions stemming from inflammation. Synonyms: UDP-L-rhamnose; Uridine 5'-(trihydrogen diphosphate), mono(6-deoxy-beta-L-mannopyranosyl) ester. Grades: 98%. CAS No. 1955-26-6. Molecular formula: C15H24N2O16P2. Mole weight: 550.30. | |
| UDP-D-glucuronide trisodium salt | UDP-D-glucuronide trisodium salt is a crucial compound used for drug metabolism studies. It acts as a donor molecule for the glucuronyl transferase enzyme, which helps in the biotransformation and detoxification of a wide range of drugs and endogenous compounds. This trisodium salt form facilitates stability and solubility, making it suitable for drug discovery and pharmacokinetic studies. Synonyms: UDP-GlcA; Uridine 5-diphosphoglucuronic acid trisodium salt; UDPGA; Uridine-diphosphate-glucuronic acid trisodium salt. Grades: 98%. CAS No. 63700-19-6. Molecular formula: C15H19N2Na3O18P2. Mole weight: 646.24. | |
| UDP-GlcNAz.2Na | UDP-GlcNAz.2Na, a biochemical compound with pivotal importance in the field of glycobiology and metabolic labeling, is a metabolic precursor for the intricate biosynthesis of azide-labeled glycans and glycoconjugates, whilst serving as a critical tool in unraveling the intricacies of glycosylation and glycan-mediated interactions in biological systems. Boasting a manifold of applications, including but not limited to the scrutiny of malignant disorders such as cancer, progressive neurodegenerative diseases as Alzheimer's Disease as well as inflammatory disorders, this molecular compound adds substantive value to multifarious scientific endeavors. Synonyms: Uridine 5-disphopho-N-acetylazidoglucosamine disodium salt. CAS No. 1611490-64-2. Molecular formula: C17H24N6O17P2Na2. Mole weight: 692.05. | |
| UDP-N-acetyl-D-galactosamine disodium salt | UDP-N-acetyl-D-galactosamine disodium salt is a nucleotide sugar used by glycosyltransferases to transfer N-acetylgalactosamine residues to substrates. Synonyms: UDP-a-N-acetyl-D-galactosamine Disodium Salt; Uridine 5'-diphospho-N-acetylgalactosamine disodium salt; 2-Acetamido-2-deoxy-a-D-galactopyranosyl uridine diphosphate disodium salt; Uridine 5'-(trihydrogen diphosphate) P'-[2-(acetylamino)-2-deoxy-alpha-D-galactopyranosyl] ester disodium. Grades: ≥95%. CAS No. 108320-87-2. Molecular formula: C17H25N3Na2O17P2. Mole weight: 651.32. | |
| UDP-xylose | UDP-xylose is a crucial compound acting as a substrate in the biosynthesis of xylose which is a sugar component involved in the glycosylation of several proteins and lipids. This enzymatic process plays an essential role in cell-cell recognition, cell signaling and immune responses. Synonyms: UDP-alpha-D-xylose. CAS No. 3616-6-6. Molecular formula: C14H22N2O16P2. Mole weight: 536.28. | |
| Ufenamate | Ufenamate is a topical analgesic. Uses: A topical analgesic. Synonyms: Benzoic acid,2-[[3-(trifluoromethyl)phenyl]amino]-, butyl ester; Flufenamic acid butyl ester. Grades: ≥95%. CAS No. 67330-25-0. Molecular formula: C18H18F3NO2. Mole weight: 337.37. | |
| UK 34787 | UK 34787 is a thromboxane inhibitor,but no detailed information has been published yet. Synonyms: UK 34787, UK-34787, UK34787; 3-((1H-imidazol-1-yl)methyl)-2-isopropyl-1H-indole. Grades: 98%. CAS No. 72818-36-1. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| UK 35493 | This molecular is a biochemical. Synonyms: UK 35493, UK-35493, UK35493; 2-(2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)ethyl)isothiazolidine 1,1-dioxide. Grades: 98%. CAS No. 113213-52-8. Molecular formula: C20H28N4O4S. Mole weight: 420.53. | |
| UK-356202 | UK-356202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM) that has been investigated for the topical treatment of chronic ulcerous wounds by topical administration. Synonyms: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202; 3-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]benzoic acid; UK-356202; 223671-94-1. Grades: >98%. CAS No. 223671-94-1. Molecular formula: C17H13ClN4O2. Mole weight: 340.767. | |
| UK 383367 | UK 383367 is a potent and selective nonpeptidic inhibitor of procollagen C-proteinase (PCP) inhibitor (IC50 = 44 nM). Uses: Potent and selective nonpeptidic inhibitor of procollagen c-proteinase (pcp) inhibitor. Synonyms: UK-383367; UK383367. Grades: ≥98%. CAS No. 348622-88-8. Molecular formula: C15H24N4O4. Mole weight: 324.381. | |
| UK-396082 | UK - 396082 is an activated thrombin activatable fibrinolysis inhibitor(Ki = 10 nM), exhibited antithrombotic efficacy in a rabbit model of venous thrombosis, yet had no effect on surgical bleeding in the rabbit. Uses: Thrombin activatable fibrinolysis. Synonyms: UK - 396082; UK396082; UK 396082; UK - 396,082; UK396,082; UK 396,082; (2S)-5-amino-2-[(1-propylimidazol-4-yl)methyl]pentanoic acid. Grades: ≥98%. CAS No. 400044-47-5. Molecular formula: C12H21N3O2. Mole weight: 239.32. | |
| Ulixertinib | Ulixertinib, also known as VRT752271, is an inhibitor of ERK protein kinase. Synonyms: (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide; BVD-523; BVD 523; BVD523; VRT752271; VRT752271; VRT 752271; Ulixertinib. Grades: 98%. CAS No. 869886-67-9. Molecular formula: C21H22Cl2N4O2. Mole weight: 433.333. | |
| UMB 68 | UMB 68 is a GHB receptor ligand exhibiting no affinity for GABA(A) or GABA(B) receptors. UMB 68 was shown not to exhibit GHB-like behavioral effects in vivo. Synonyms: UMB68, UMB-68, UMB 68, UMB-68 sodium; Sodium 4-Hydroxy-4methylpentanoate. CAS No. 581099-89-0. Molecular formula: C6H11NaO3. Mole weight: 154.14. | |
| UNC0638 hydrate | UNC 0638 is a selective inhibitor of G9a/EHMT2 and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and> 10000 nM for a panel of other histone methyltransferases). UNC 0638 inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Synonyms: UNC 0638; UNC0638; UNC-0638; 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine. Grades: ≥99% by HPLC. CAS No. 1255517-77-1. Molecular formula: C30H49N5O3. Mole weight: 527.7. | |
| UNC2170 maleate | UNC2170 is a p53-Binding protein 1 (53BP1) antagonist that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer. Synonyms: 3-bromo-N-[3-(tert-butylamino)propyl]benzamide maleate. Grades: ≥95%. Molecular formula: C14H21BrN2O·C4H4O4. Mole weight: 429.3. | |
| UNC 2327 | UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Synonyms: UNC2327; UNC-2327; UNC 2327; N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea. Grades: ≥99% by HPLC. CAS No. 1426152-53-5. Molecular formula: C14H17N5O2S. Mole weight: 319.38. | |
| UNC2541 | UNC2541 is a potent specific inhibitor of Mer tyrosine kinase (MerTK). Synonyms: UNC-2541; UNC 2541. Grades: ≥98% by HPLC. CAS No. 1612782-86-1. Molecular formula: C24H34FN7O2. Mole weight: 471.6. | |
| UNC2881 | UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. Synonyms: UNC2881; UNC 2881; UNC-2881. Grades: 98%. CAS No. 1493764-08-1. Molecular formula: C25H33N7O2. Mole weight: 463.586. | |
| UNC 3866 | UNC 3866 is a potent and high affinity CBX4 and CBX7 inhibitor (Ki = 94 and 97 nM, respectively) displaying > 6-fold selectivity over other CBX and CDY family members. UNC 3866 was shown to inhibit the proliferation of PC3 cells in vitro. Synonyms: UNC3866, UNC-3866, UNC 3866; N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester. CAS No. 1872382-47-2. Molecular formula: C43H66N6O8. Mole weight: 795.02. | |
| UNC6852 | UNC6852 is a selective polycomb inhibitory complex 2 (PRC2) degradation agent based on PROTAC. Synonyms: UNC-6852; UNC 6852; (2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 2688842-08-0. Molecular formula: C43H48N10O6S. Mole weight: 832.99. | |
| UNC-926 | UNC-926 is a methyl-lysine (Kme) reader domain inhibitor which binds to the MBT domain of L3MVTL protein (IC50 = 3.9 μM). Synonyms: UNC-926; UNC 926; UNC926; (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone. CAS No. 1184136-10-4. Molecular formula: C16H21BrN2O. Mole weight: 337.25. | |
| UNIL-088 | UNIL088 is a water-soluble prodrug of cyclosporine A (CsA), can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. Uses: Prodrug of cyclosporine. Synonyms: UNIL-088, UNIL 088, UNIL088, Cyclosporin A; (1R, 2R, E)-1-((2S, 5S, 11S, 14S, 17S, 20S, 23R, 26S, 29S, 32S)-5-ethyl-11, 17, 26, 29-tetraisobutyl-14, 32-diisopropyl-1, 7, 10, 16, 20, 23, 25, 28, 31-nonamethyl-3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33-undecaoxo-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecaazacyclotritriacontan-2-yl)-2-methylhex-4-en-1-yl N-(N-((1-acetoxyethoxy)carbonyl)-O-phosphono-L-seryl)-N-methylglycinate. Grades: ≥95%. CAS No. 473545-11-8. Molecular formula: C73H128N13O22P. Mole weight: 1570.86. | |
| Unithiol | Unithiol is a chelating agent used as an antidote against for the treatment of heavy metals and metalloid intoxication. It can also be used for animals. Synonyms: DMPS. Grades: >98%. CAS No. 4076-2-2. Molecular formula: C3H7O3S3Na. Mole weight: 210.27. | |
| UPF-648 | Potent and selective inhibitor of kynurenine-3-monooxygenase (KMO, or kynurenine hydroxylase) activity (IC50: 20 nM); Active (+)-(1S,2S)-enantiomer; Useful tool for research on cognitive enhancement and neuroprotection in the brain. Synonyms: UPF-648; UPF 648; UPF648. Grades: >98%. CAS No. 213400-34-1. Molecular formula: C11H8Cl2O3. Mole weight: 259.09. | |
| UPF-648 sodium salt | UPF-648 sodium salt is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity. Synonyms: UPF-648 sodium salt; UPF 648 sodium salt; UPF648 sodium salt. Grades: >98%. CAS No. 1465017-87-1. Molecular formula: C11H7Cl2NaO3. Mole weight: 281.07. | |
| UPGL00004 | UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 value of 29 nM. Synonyms: 2-phenyl-N-[5-[[1-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]piperidin-4-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide. CAS No. 1890169-95-5. Molecular formula: C25H26N8O2S2. Mole weight: 534.66. | |
| URB602 | URB602, a cell-permeable N-biphenyl carbamate compound, is a selective inhibitor of monoglycerol lipase (MGL). The IC50 = 28 μM and Km = 20 μM. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 μM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2. Synonyms: cyclohexyl [1,1'-biphenyl]-3-ylcarbamate; URB602; URB-602; URB 602. CAS No. 565460-15-3. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
| URB754 | URB754 is a potent and non-competitive inhibitor of monoacylglycerol lipase (MAGL) with IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. The MAGL inhibitory activity of URB754 was reported to be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial samples. Synonyms: URB-754; URB 754; 6-methyl-2-(4-methylanilino)-3,1-benzoxazin-4-one. Grades: >98%. CAS No. 86672-58-4. Molecular formula: C16H14N2O2. Mole weight: 266.3. | |
| Urea,N-(4-ethoxyphenyl)- | N-(4-ethoxyphenyl)-Urea is an artificial sweetener about 250 times sweeter than sucrose, which is prohibited by FDA from use in human food for its carcinogenic property. Uses: Artificial sweetener. Synonyms: Dulcin; 1-(4-Ethoxyphenyl)urea; N-(4-Ethoxyphenyl)urea; (4-ethoxyphenyl)urea; P-Ethoxyphenylurea. CAS No. 150-69-6. Molecular formula: C9H12N2O2. Mole weight: 180.23. | |
| Uridine 5'-diphosphate disodium salt | UDP disodium salt is an endogenous P2Y receptor agonist which preferentially activates P2Y6. It also acts as a competitive antagonist at P2Y14 receptors. Synonyms: UDP-Na2; UDP disodium salt; Uridine 5'-diphosphoric acid disodium salt; Uridine 5'-(Trihydrogen diphosphate) Disodium Salt. Grades: ≥97% by HPLC. CAS No. 27821-45-0. Molecular formula: C9H12N2Na2O12P2. Mole weight: 448.12. | |
| Uridine 5-diphosphogalactose disodium salt | Uridine 5-diphosphogalactose disodium salt is an indispensable compound in the biomedical field, serving as a fundamental precursor for diverse glycoconjugates and glycans. By actively participating in the formation of cell surface receptors and extracellular matrix molecules, this product assumes a pivotal function in the intricate synthesis of nucleotide sugars and glycosylation processes. Its usability extends to studying drug-resistant epilepsy, neurodegenerative ailments and immunological disorders. Synonyms: UDP-D-galactose disodium salt; UDP-α-D-Gal disodium salt; Uridine 5'-(trihydrogen diphosphate)? P'-α-D-galactopyranosyl ester disodium salt; UDP-galactose disodium salt. Grades: ≥95%. CAS No. 137868-52-1. Molecular formula: C15H22N2Na2O17P2. Mole weight: 610.27. | |
| Uridine 5'-Monophosphate Disodium Salt | Uridine 5'-Monophosphate Disodium Salt can be used in dietary supplement and RNA rich food. It may be beneficial for cognitive function. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Uridine Monophosphate Disodium; 5'-Uridylic Acid Disodium Salt; Disodium 5'-uridylate; Disodium UMP; UMP sodium salt; Sodium UMP. Grades: 98% by HPLC. CAS No. 3387-36-8. Molecular formula: C9H11N2Na2O9P. Mole weight: 368.15. | |
| URMC-099 | URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. MLK3 activation is associated with many of the pathologic hallmarks of HAND and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition. Synonyms: URMC099; URMC 099; URMC-099. Grades: 98%. CAS No. 1229582-33-5. Molecular formula: C27H27N5. Mole weight: 421.55. | |
| Urolithin C | Urolithin C is a chebulic ellagitannins metabolite with antioxidant activity. Synonyms: 6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-. CAS No. 165393-06-6. Molecular formula: C13H8O5. Mole weight: 244.2. | |
| Urotensin II (goby) trifluoroacetate salt | Urotensin II is a potent peptide vasoconstrictor and an agonist of the urotensin (UT) receptor. For its distribution in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it has been identified as a potential target for therapies of atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Synonyms: U-II; Urotensin II (G. mirabilis). Grades: ≥95%. Molecular formula: C62H84N14O17S2·xCF3COOH. Mole weight: 1361.56. | |
| Urotensin II (human) trifluoroacetate salt | Urotensin II is a potent peptide vasoconstrictor and an agonist of the urotensin (UT) receptor. For its distribution in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it has been identified as a potential target for therapies of atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Synonyms: hU II. Grades: ≥95%. Molecular formula: C64H85N13O18S2·xCF3COOH. Mole weight: 1388.57. | |
| Usaramine | Usaramine is a pyrrolizidine alkaloid found in the seeds of Crolatalaria pallida. Uses: Antiseptic. Synonyms: NISTC15503874; (15E)-12,18-Dihydroxysenecionan-11,16-dione; Mucronatine; (15E)-Retrorsine; trans-Retrorsine; Usaramin. Grades: >98%. CAS No. 15503-87-4. Molecular formula: C18H25NO6. Mole weight: 351.4. | |
| Usistapide | Usistapide is a Microsomal triglyceride transfer protein inhibitor under development for the treatment of obesity and type 2 diabetes. Uses: Microsomal triglyceride transfer protein inhibitors. Synonyms: JNJ-16269110, JNJ16269110, JNJ 16269110, R256918, R 256918, R-256918, Usistapide; methyl (2R) -2-phenyl-2- [4- [4- [ [2- [4- (trifluoromethyl) phenyl] benzoyl] amino] phenyl] piperidin-1-yl] acetate. Grades: ≥98%. CAS No. 403989-79-7. Molecular formula: C34H31F3N2O3. Mole weight: 572.63. | |
| Usnic acid | Usnic acid is a naturally occurring dibenzofuran derivative found in several lichen species with the formula C18H16O7. It was first isolated by German scientist W. Knop in 1844 and first synthesized between 1933-1937 by Curd and Robertson. Usnic acid was identified in many genera of lichens including Usnea, Cladonia, Hypotrachyna, Lecanora, Ramalina, Evernia, Parmelia and Alectoria. Although it is generally believed that usnic acid is exclusively restricted to lichens, in a few unconfirmed isolated cases. The compound was found in kombucha tea and non-lichenized ascomycetes. At normal conditions, usnic acid is a bitter, yellow, solid substance.It is known to occur in nature in both the d-and l-forms as well as a racemic mixture. Salts of usnic acid are called usnates (e.g. copper usnate). Usnic acid can be used in cosmetics material. Uses: Bleeding, antibacterial, anti-inflammatory. Synonyms: 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione; (±)-Usnic acid; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione; NSC 8517; Usnein; Usniacin; Usno. Grades: >98%. CAS No. 125-46-2. Molecular formula: C18H16O7. Mole weight: 344.32. | |
| UTL-5G | UTL-5G (GBL-5g) is an anti-inflammatory TNF-α inhibitor. It reduces cisplatin-induced hepatotoxicity, nephrotoxicity and bone marrow toxicity by inhibiting TNF-α and other factors. Synonyms: 3-Isoxazolecarboxamide, N-(2,4-Dichlorophenyl)-5-Methyl-. Grades: 98%. CAS No. 646530-37-2. Molecular formula: C11H8Cl2N2O2. Mole weight: 271.1. | |
| V5 Epitope Tag Peptide | V5 Epitope Tag Peptide, a tag peptide derived from a small epitope present on the P and V proteins of the paramyxovirus of simian virus 5, is used as a blocking peptide in WB or ELISA for the V5 Epitope tag antibody. Synonyms: H-Gly-Lys-Pro-Ile-Pro-Asn-Pro-Leu-Leu-Gly-Leu-Asp-Ser-Thr-OH; L-Threonine, glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolyl-L-leucyl-L-leucylglycyl-L-leucyl-L-α-aspartyl-L-seryl-; Glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolyl-L-leucyl-L-leucylglycyl-L-leucyl-L-α-aspartyl-L-seryl-L-threonine. Grades: ≥95%. CAS No. 141074-86-4. Molecular formula: C64H108N16O20. Mole weight: 1421.64. | |
| V-9302 | V-9302 is a competitive antagonist of transmembrane glutamine flux, which selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. Synonyms: EX-A2965; (2S) -2-amino-4-[bis[[2-[ (3-methylphenyl) methoxy]phenyl]methyl]amino]butanoic acid. CAS No. 1855871-76-9. Molecular formula: C34H38N2O4. Mole weight: 538.68. | |
| Vaccarin | Vaccarin is a major flavonoid glycoside in Vaccariae semen, and is expected to be useful in the treatment of vascular diseases. Uses: Anti-early pregnancy. Synonyms: 6-(2-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one. Grades: >98%. CAS No. 53452-16-7. Molecular formula: C32H38O19. Mole weight: 726.64. | |
| Vaccarin E | Vaccarin E is a compound of the flavonoid class isolated from the Semen Vaccariae. Grades: >98%. Molecular formula: C42H48O22. Mole weight: 904.82. | |
| VAL-083 | VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis. Synonyms: Dianhydrodulcitol; Dulcitol diepoxide. Grades: 0.98. CAS No. 23261-20-3. Molecular formula: C6H10O4. Mole weight: 146.14. | |
| Valacyclovir Impurity J | An impurity of Acyclovir. Synonyms: Acyclovir L-Isoleucinate; 142963-63-1; UNII-7G0033O85U7G0033O85U; 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S,3S)-2-amino-3-methylpentanoate. Grades: > 95%. CAS No. 142963-63-1. Molecular formula: C14H22N6O4. Mole weight: 338.37. | |
| Valbenazine | Valbenazine is a potent and highly selective vesicular monoamine transporter 2(VMAT2) inhibitor. It is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy. It is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines. It significantly improved tardive dyskinesia and was well tolerated in patients. It is an experimental drug being investigated for use in the treatment of tardive dyskinesia and Tourette syndrome. It was developed by Neurocrine Biosciences. Uses: Valbenazine is an experimental drug being investigated for use in the treatment of tardive dyskinesia and tourette syndrome. Synonyms: Ingrezza; L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester; (S)-2-amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester; Tetrabenazine Related Impurity 28 (2R, 3R, 11bR, L-Val); [(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] (2S)-2-amino-3-methylbutanoate; NBI-98854; NBI98854; MT-5199; MT5199; NBI 98854; MT 5199. Grades: >98%. CAS No. 1025504-45-3. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
| Valganciclovir HCl | Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2'-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase. Synonyms: RS 079070-194; Ro 107-9070/194; Valcyte; (S)-Valganciclovir Hydrochloride. Grades: >98%. CAS No. 175865-59-5. Molecular formula: C14H23ClN6O5. Mole weight: 390.82. | |
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