BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Swertianin | Swertianin is found in the herbs of Gentiana bavarica, it has potential anti-inflammatory and antinoceceptive which could be used as a drug candidate against inflammation related conditions. Synonyms: Gentiakochianin; 1,2,8-Trihydroxy-6-methoxy-9H-xanthen-9-one. Grades: > 95%. CAS No. 20882-75-1. Molecular formula: C14H10O6. Mole weight: 274.23. |  |
| Swertiaperennin | Swertiaperennin is a xanthone isolated from Swertia bimaculata. Synonyms: Methylswertianin; 1,8-Dihydroxy-2,6-dimethoxy-9H-xanthen-9-one; 2-O-Methylswertianin. Grades: 98%. CAS No. 22172-17-4. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Swertisin | Swertisin efficiently changed the morphology of NIH3T3 cells from fibroblastic to round aggregate cell cluster in huge numbers. Dithizone (DTZ) stain primarily confirmed differentiation and gene expression studies signified rapid onset of differentiation signaling cascade in Swertisin-induced ILCC. Synonyms: Flavocommelitin; 6-C-glucopyranosyl-7-O-methylapigenin; Apigenin 6-glucosyl-7-O-methyl ether. Grades: >98%. CAS No. 6991-10-2. Molecular formula: C22H22O10. Mole weight: 446.4. | |
| SYBR Green I | SYBR Green I is a fluorescent probe used for staining double stranded DNA or oligonucleotides in agarose or polyacrylamide gels. Synonyms: N,N-dimethyl-N'-[4-[(E)-(3-methyl-1,3-benzothiazol-2-ylidene)methyl]-1-phenylquinolin-1-ium-2-yl]-N'-propylpropane-1,3-diamine; Nucleic acid gel stain. CAS No. 163795-75-3. Molecular formula: C32H37N4S. Mole weight: 509.73. | |
| Sylvestroside I | Sylvestroside I is a compound of the iridoids found in Acicarpha tribuloides Juss. Synonyms: methyl (1S,4aS,6S,7R,7aS)-6-[(2S,3R,4S)-3-ethenyl-4-(2-hydroxyethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carbonyl]oxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate. Grades: >98%. CAS No. 71431-22-6. Molecular formula: C33H48O19. Mole weight: 748.728. | |
| SYM 2081 | SYM 2081 is a highly selective and potent kainate receptor agonist with IC50 for 35 nM, which is almost 200- and 3,000-fold selectivity over NMDA and AMPA receptors respectively. It also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Synonyms: SYM2081; SYM-2081; SYM 2081; (2S,4R)-Me-Glu. (2S,4R)-4-Methylglutamic Acid; (4R)- 4-Methyl-L-glutamic Acid; erythro-L-4-Methylglutamic Acid; L-erythro-γ-Methylglutamic Acid; (2S,4R)-2-amino-4-methylpentanedioate. Grades: ≥97% by HPLC. CAS No. 31137-74-3. Molecular formula: C6H11NO4. Mole weight: 161.16. | |
| SYR127063 | SYR127063 is a selective HER2 inhibitor with IC50 value of 11 nM for HER2, and > 10000 nM for HER4. It can bind to HER2 in an active-like conformation. Synonyms: SYR127063; SYR-127063; SYR 127063; BDBM92454; BDBM-92454; BDBM 92454. 2- (2- (4- ( (3-chloro-4- (3- (trifluoromethyl) phenoxy) phenyl) amino) -5H-pyrrolo[3, 2-d]pyrimidin-5-yl) ethoxy) ethan-1-ol. Grades: 98%. CAS No. 871026-18-5. Molecular formula: C23H20ClF3N4O3. Mole weight: 492.88. | |
| Syringetin-3-O-rutinoside | Syringetin-3-O-rutinoside is found in the leaves of Corylus heterophylla Fisch. Synonyms: Syringetin-3-O-rutinoside; 53430-50-5; HY-N7889; CS-0138753; 3-[(6-O-alpha-L-Rhamnopyranosyl-beta-D-glucopyranosyl)oxy]-4',5,7-trihydroxy-3',5'-dimethoxyflavone. Grades: > 95%. CAS No. 53430-50-5. Molecular formula: C29H34O17. Mole weight: 654.57. | |
| (S)-ZINC 3573 | Negative control for (R)-ZINC 3573. Displays no activity at MRGPRX2 at concentrations below 100 μM. Synonyms: (3S)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrroldinamine; N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine. Grades: ≥98% by HPLC. CAS No. 2095596-11-3. Molecular formula: C18H21N5. Mole weight: 307.4. | |
| SZL P1-41 | SZL P1-41 is a Skp2 inhibitor that prevents assembly of Skp2-Skp1 complexes. SZL P1-41 selectively suppresses Skp2 SCF E3 ligase activity but not the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. SZL P1-41 exhibits antitumor effects in multiple animal models and cancer cell lines. Synonyms: SZL-P1-41; SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III; 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one; SKP2 E3 Ligase Inhibitor III. Grades: ≥98% by HPLC. CAS No. 222716-34-9. Molecular formula: C24H24N2O3S. Mole weight: 420.52. | |
| T2AA | T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor. T2AA inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM), leading to the suppression of DNA replication stress by stalling DNA replication forks. T2AA inhibits the interaction of PCNA with DNA polymerase δ and arrests cell growth in S-phase. Synonyms: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol; 4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol. Grades: ≥98% by HPLC. CAS No. 1380782-27-3. Molecular formula: C15H15I2NO3. Mole weight: 511.09. | |
| T-3364366 | T-3364366 is a reversible and slow-binding Delta-5 desaturase (D5D) inhibitor. Ki is less than 2.7 nM and a dissociation half-life is more than 2.0 h. D5D is an attractive drug target for inflammatory-related. Uses: Inflammatory-related. Synonyms: T-3364366, T 3364366, T3364366; N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide. Grades: 98%. CAS No. 1356354-09-0. Molecular formula: C18H16F3N3O3S2. Mole weight: 443.46. | |
| T-3775440 hydrochloride | T-3775440 HCl is an irreversible and selective LSD1 inhibitor. Synonyms: T-3775440 HCl; N-[4-[ (1S, 2R) -2- (cyclopropylmethylamino) cyclopropyl]phenyl]-1-methylpyrazole-4-carboxamide hydrochloride. CAS No. 1422535-52-1. Molecular formula: C18H23ClN4O. Mole weight: 346.85. | |
| T-5224 | T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. Accumulating evidence supports that AP-1 plays an important role in several severe disorders including cancer, fibrosis, and organ injury, as well as inflammatory disorders such as asthma, psoriasis, and rheumatoid arthritis. Synonyms: T5224; T 5224. Grades: >98%. CAS No. 530141-72-1. Molecular formula: C29H27NO8. Mole weight: 517.53. | |
| T56-LIMKi | T56-LIMKi is a selective inhibitor of LIMK2 that reduces phosphorylated cofilin and inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. Synonyms: 3-methyl-N-[3-[[3- (trifluoromethyl) phenyl]carbamoyl]phenyl]-1, 2-oxazole-5-carboxamide; 3-methyl-N- (3- ( (3- (trifluoromethyl) phenyl) carbamoyl) phenyl) isoxazole-5-carboxamide ; T-5601640; T 5601640; T5601640; T56LIMKi; T56 LIMKi; T56-LIMKi. CAS No. 924473-59-6. Molecular formula: C19H14F3N3O3. Mole weight: 389.33. | |
| T807 | T807, also known as 18F-AV-1451, is a novel tau positron emission tomography (PET) tracer. Synonyms: 7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; (18)AV-1451; (18F)1451; (18F)AV-1451; (18F)T807 compound; (F-18)-AV-1451; 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole; AV-1451; AV1451; F-18-AV-1451; T-807; T807 compound. CAS No. 1415379-56-4. Molecular formula: C16H10FN3. Mole weight: 263.27. | |
| Taccalonolide A | Taccalonolide A is a steroid with antimalarial activities. It is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. Grades: 98%. CAS No. 108885-68-3. Molecular formula: C36H46O14. Mole weight: 702.74. | |
| Tacrine | Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist for the palliative treatment of mild to moderate dementia of the Alzheimer's type. Uses: A centrally acting anticholinesterase and indirect cholinergic agonist. Synonyms: CS 12602, CS 12602, CS 12602; 1,2,3,4-Tetrahydro-5-aminoacridine; 1,2,3,4-tetrahydro-9-acridinamin; 1,2,3,4-tetrahydro-9-amino-acridin; 1,2,3,4-Tetrahydro-9-aminoacridine; 5-Amino-6,7,8,9-tetrahydroacridine; Acridine, 1,2,3,4-tetrahydro-9-amino-; Acridine, 9-amino-1,2,3,4-tetrahydro-. Grades: ≥95%. CAS No. 321-64-2. Molecular formula: C13H14N2. Mole weight: 198.27. | |
| Tafenoquine | Tafenoquine is an oral active and an 8-aminoquinoline antimalaria drug. It is being investigated as a potential treatment for malaria, as well as for malaria prevention.It is for treatment of the hypnozoite stages of Plasmodium vivax and Plasmodium ovale that are responsible for relapse of these malaria species even when the blood stages are successfully cleared. It targets leishmania respiratory complex III and induces apoptosis. It has a long half-life of approximately 14 days and is generally safe and well tolerated, thus therefore a single treatment may be sufficient to clear hypnozoites. It was manufactured by GlaxoSmithKline and in clinic phase 3 trials. Uses: Tafenoquine is being investigated as a potential treatment for malaria, as well as for malaria prevention.it is for treatment of the hypnozoite stages of plasmodium vivax and plasmodium ovale. Synonyms: 4-[5-[3-(Trifluoromethyl)phenoxy]-2, 6-dimethoxy-4-methyl-8-quinolinylamino]-1-pentanamine; 8-[(4-Amino-1-methylbutyl)amino]-2, 6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinoline; N4-(2, 6-diMethoxy-4-Methyl-5-(3-(trifluoroMethyl)phenoxy)quinolin-8-yl)pentane-1, 4-diamine; WR-238605; WR238605; Etaquine. Grades: >98%. CAS No. 106635-80-7. Molecular formula: C24H28F3N3O3. Mole weight: 463.50. | |
| Tafenoquine Succinate | Tafenoquine is a medication for the prevention and treatment of malaria. Synonyms: WR 238605; WR-238605; WR238605. CAS No. 106635-81-8. Molecular formula: C28H34F3N3O7. Mole weight: 581.6. | |
| TAK-603 | TAK-603, a quinoline derivative, has been found to be an immunomodulator that was once studied in sorts of inflammatory diseases. Synonyms: TAK-603, TAK603, TAK 603; Ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate; UNII-W6RZK26FCB; W6RZK26FCB; AC1L4BH6. Grades: 98%. CAS No. 158146-85-1. Molecular formula: C25H26N4O6. Mole weight: 478.51. | |
| TAK-683 | TAK-683 is an investigational peptide derivative of metastin under the development of Millennium. It is a KISS1R protein agonist. Phase I development for prostate cancer was discontinued. Uses: Prostate cancer. Synonyms: TAK-683, TAK 683, TAK683; (S)-2-((R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanamido)-N1-((8S,11S,17S,20S,21R)-8-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-17-benzyl-21-hydroxy-3-imino-11-isobutyl-10,13,16,19-tetraoxo-2,4,9,12,14,15,18-heptaazadocosan-20-yl)succinamide. Grades: 98%. CAS No. 872719-49-8. Molecular formula: C64H83N17O13. Mole weight: 1298.47. | |
| Takinib | Takinib is a potent and selective TAK1 inhibitor with IC50 value of 9.5 nM. It induces apoptosis following TNF-α stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Synonyms: EDHS-206; GTPL9655; 3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide. CAS No. 1111556-37-6. Molecular formula: C18H18N4O2. Mole weight: 322.36. | |
| Talabostat | Talabostat, also called as PT100 or Val-boroPro, is a potent, nonselective and orally available dipeptidyl peptidase IV(DPP-IV) inhibitor (Ki= 0.18 nM) with antineoplastic and hematopoiesis- stimulating activities. Synonyms: [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid; L-valinyl-L-boroproline; PT 100; PT-100; PT100 cpd; talabostat; valinyl-boroproline. CAS No. 149682-77-9. Molecular formula: C9H19BN2O3. Mole weight: 214.07. | |
| Talaporfin sodium | Talaporfin sodium is a natural chlorophyll-based, and water soluble PDT photosensitizer consisting of chlorin e6, derived from chlorophyll, and L-aspartic acid with photosensitizing activity. After intratumoral activation by light emitting diodes, talaporfin sodium forms an extended high energy conformational state that generates singlet oxygen, which can kill target tissues with minimal side effects through vascular closure and apoptosis. Constant illumination can activate each molecule of talaporfin many times, resulting in a continuous supply of singlet oxygen molecules. Talaporfin kills all tumour cells in the targeted zone, rather than only the minority of cells undergoing rapid division, as in the case of chemotherapy. There are no serious toxicities to date. Talaporfin sodium was approved in 2004 in Japan, and is currently in phase III trials in USA. Synonyms: LS11, LS-11, LS 11, ME2906, ME 2906, ME-2906, NPe6; mono-L-aspartyl chlorin e6; Laserphyrin; Mono-L-aspartyl chlorin e6; LS-11; ME-2906. Grades: >98%. CAS No. 220201-34-3. Molecular formula: C38H37N5Na4O9. Mole weight: 799.69. | |
| Talazoparib | Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Uses: For research used only. Synonyms: BMN-673; LT-673. BMN 673; LT 673. BMN673; LT673. Grades: 98%. CAS No. 1207456-01-6. Molecular formula: C19H14F2N6O. Mole weight: 380.359. | |
| Talsupram hydrochloride | Talsupram hydrochloride is a selective noradrenalin reuptake (SLC6A2) inhibitor, displaying high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 = 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Uses: Antidepressant. Synonyms: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride; 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methylpropan-1-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 25487-28-9. Molecular formula: C20H25NS.HCl. Mole weight: 347.95. | |
| Tamibarotene | Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. It is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It may show sustained plasma levels compared to ATRA. It may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium. Synonyms: Retinobenzoic acid; Amnoid; AMNOLAKE; Am80; Am 80; Am-80; SY-1425; SY 1425; SY1425; Tamibarotene. Grades: 98%. CAS No. 94497-51-5. Molecular formula: C22H25NO3. Mole weight: 351.44. | |
| Tamsulosin hydrochloride | Tamsulosin hydrochloride is a potent and selective prostatic alpha1A adrenergic receptor antagonist for the treatment of benign prostatic hypertrophy. Synonyms: Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1); Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride; Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride, (R)-; (-)-LY 253352; (-)-YM 12617; (R)-(-)-YM 12617; Dynapress; Flomax; Harnal; LY 253351; Omic; Omnic; URIMAX; URIPRO; YM 12617-1; YM 617; Yutanal; (R)-Tamsulosin Hydrochloride. Grades: ≥95%. CAS No. 106463-17-6. Molecular formula: C20H28N2O5S.HCl. Mole weight: 444.97. | |
| Tamsulosin Impurity G | One of the impurities of Tamsulosin, which is an α1-adrenoceptor antagonist and could be used against benign prostatic hypertrophy. Synonyms: (S)-Tamsulosin Hydrochloride; 5-[(2S)-2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride; (+)-LY 253352. Grades: > 95%. CAS No. 106463-19-8. Molecular formula: C20H29ClN2O5S. Mole weight: 444.97. | |
| Tapderimotide | Tapderimotide is an immune reagent for active immunity. Synonyms: L-Glutamic acid, L-arginyl-L-threonyl-L-phenylalanyl-L-valyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-prolyl-L-prolyl-L-prolyl-. Grades: >98%. CAS No. 1221082-45-6. Molecular formula: C79H129N25O22. Mole weight: 1781.02. | |
| Tapinarof | Tapinarof is an aryl hydrocarbon receptor (AhR) agonist that exhibits demonstrated efficacy for patients with psoriasis and atopic dermatitis. Synonyms: Benvitimod; WBI-1001; WBI 1001; WBI1001; 3,5-Dihydroxy-4-isopropylstilbene. Grades: ?98%. CAS No. 79338-84-4. Molecular formula: C17H18O2. Mole weight: 254.32. | |
| Taprostene | Taprostene is a prostacyclin (PGI2) analog that acts as an agonist of the prostacyclin receptor, IP. Uses: Cardiovascular agents. Synonyms: CG 4203; Rheocyclan; 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(E,3S)-3-cyclohexyl-3-hydroxyprop-1-enyl]-5-hydroxy-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]methyl]benzoic acid. Grades: ≥95%. CAS No. 108945-35-3. Molecular formula: C24H30O5. Mole weight: 398.5. | |
| Tariquidar dihydrochloride | Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Tariquidar was found to reverse drug resistance in multiple MDR cell lines. Tariquidar binds to the p-glycoprotein transporter, and inhibits transmembrane transport of anticancer drugs, leading to increased concentrations and enhanced cytotoxic effects of anticancer drugs. Synonyms: N-[2-[[[4-[2- (3, 4-dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]amino]carbonyl]-4, 5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1992047-62-7. Molecular formula: C38H38N4O6.2HCl. Mole weight: 719.66. | |
| Tariquidar methanesulfonate hydrate | Tariquidar methanesulfonate is a potent and selective noncompetitive inhibitor of P-glycoprotein(Kd =5.1 nM). Uses: P-glycoprotein inhibitor, potent and selective. Synonyms: XR 9576; XR9576; XR-9576;N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;methanesulfonic acid;trihydrate. Grades: ≥98%. CAS No. 625375-83-9. Molecular formula: C40H52N4O15S2. Mole weight: 892.99. | |
| TAS-102 | TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Synonyms: Tipiracil / Trifluridine; Viroptic mixture with 5-CIMU; TAS 102; EX-A1755; Tipiracil hydrochloride / Trifluridine. CAS No. 733030-01-8. Molecular formula: C9H11ClN4O2·HCl·C10H11F3N2O5. Mole weight: 575.328. | |
| Taurochenodeoxycholic acid | Taurochenodeoxycholic acid is a bile salt formed in the liver. It solubilizes fats in the small intestine and is itself absorbed. Synonyms: Taurochenodeoxycholate; Chenyltaurine; Chenodeoxycholyltaurine. CAS No. 516-35-8. Molecular formula: C26H45NO6S. Mole weight: 499.707. | |
| Taurocholic Acid Sodium Salt Hydrate | Choleretic; Its sodium salt is a bile salt formed in the liver by conjugation of cholic acid with taurine that is involved in the emulsification of lipids used to solubilize lipids and membrane-bound proteins. Uses: Used to solubilize lipids and membrane-bound proteins. Synonyms: 2-[[(3α, 5β, 7α, 12α)-3, 7, 12-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. Grades: ≥98%. CAS No. 345909-26-4. Molecular formula: C26H46NNaO8S. Mole weight: 555.70. | |
| Tautomycetin | Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 = 1.6 and 62 nM for PP1 and PP2, respectively) used as an immunosuppressive agent. Tautomycetin induces apoptosis in activated T cells, and inhibits PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Synonyms: (1R, 2S, 3R, 6S, 7S, 10S, 12R, 15E, βR, 3R)-16-Ethyl-3, 7-dihydroxy-1, 2, 6, 10, 12-pentamethyl-5, 14-dioxo-15, 17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester. Grades: ≥95% by HPLC. CAS No. 119757-73-2. Molecular formula: C33H50O10. Mole weight: 606.75. | |
| Tazarotene | Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with RARalpha-selective ligand. Also, it is a derivative of retinoic acid. Tazarotene is a third-generation prescription topical retinoid that is primarily used to treat plaque psoriasis and acne and is also used to treat photoaged and photodamaged skin. Synonyms: AGN190168; AGN-190168; AGN 190168; Avage; Fabior; Suretin; Zorac; Tazorac; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; 6-(4,4-Dimethyl-thiochroman-6-ylethynyl)-nicotinic acid ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester. Grades: 98%. CAS No. 118292-40-3. Molecular formula: C21H21NO2S. Mole weight: 351.46. | |
| TB5 | TB5 is a competitive and reversible monoamine oxidase B (MAO-B) inhibitor (Ki values 1.45 μM and 0.11 μM for hMAO-A and hMAO-B, respectively). TB5 is identified as potential treatment of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Uses: Potential treatment of neurodegenerative disorders. Synonyms: TB5, TB 5, TB-5; (2E)-1-(5-Bromo-2-thienyl)-3-[4-(dimethylamino)phenyl]-2-propen-1-one. Grades: 99%. CAS No. 948841-07-4. Molecular formula: C15H14BrNOS. Mole weight: 336.25. | |
| tBID | tBID specificly inhibits homeodomain-interacting protein kinase 2 (HIPK2) (IC50=?0.33 μM). Synonyms: 4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindole-1,3-dione. CAS No. 1639895-85-4. Molecular formula: C11H3Br4N3O2. Mole weight: 528.78. | |
| tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | A 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy. Synonyms: Semaglutide Side Chain; Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid; (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid. Grades: ≥98%. CAS No. 1118767-16-0. Molecular formula: C43H79N3O13. Mole weight: 846.11. | |
| TC-E3 5032 | TC-E3 5032 is a linker used in PROTAC technology that can be used in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders. Synonyms: E3 ligase Ligand 4; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-; Thalidomide 4-fluoride; Thalidomide fluoride; 4-Fluoro-thalidomide; Cereblon ligand 4;E3 ligase Ligand 4; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione. Grades: ≥ 98%. CAS No. 835616-60-9. Molecular formula: C13H9FN2O4. Mole weight: 276.22. | |
| TC-E 5001 | TC-E 5001 is a dual tankyrase (TNKS) inhibitor (Kd = 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that inhibits Wnt signaling and stabilizes Axin2 levels. Synonyms: TC-E 5001; TC E 5001; TCE5001; TCE-5001; TC-E-5001; 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole. Grades: ≥98% by HPLC. CAS No. 865565-29-3. Molecular formula: C20H19N5O3S. Mole weight: 409.46. | |
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM) with no inhibitory effects on CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Synonyms: TC-E 5003; TC E 5003; TCE 5003; TCE-5003; TCE5003; N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide); 4-(2,2-Dichloroacetamido)phenyl sulfone. Grades: ≥98% by HPLC. CAS No. 17328-16-4. Molecular formula: C16H14Cl2N2O4S. Mole weight: 401.26. | |
| TC-E 5007 | TC-E 5007 is an irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 = 145 and 242 nM, respectively) with selectivity over DPP-IV, DPP-2 and FAP. Synonyms: TC-E 5007; TC E 5007; TCE 5007; TCE-5007; TCE5007; (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-48-9. Molecular formula: C14H20N2O.HCl. Mole weight: 268.78. | |
| TC-FPR 43 | TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM) that inhibits fMLP- and IL-8-induced neutrophil migration and induces calcium mobilization. TC-FPR 43 was shown to suppress inflammation in a mouse model of acute inflammation. It also acts as an ALX agonist. Synonyms: TCFPR43; TC FPR 43; TC-FPR-43; N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea; Pyrazolone, 1. Grades: ≥98% by HPLC. CAS No. 903895-98-7. Molecular formula: C20H21ClN4O2. Mole weight: 384.86. | |
| TC-G 1001 | TC-G 1001 is a GPR35 agonist (pEC50 = 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays, respectively) displaying 1000-fold greater potency at human GPR35 receptors than mouse and rat GPR35 orthologs in an IP1 accumulation assay. Synonyms: TC-G 1001; TC G 1001; TCG 1001; TC-G-1001; TCG1001; 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 494191-73-0. Molecular formula: C17H11FN2O3S. Mole weight: 342.34. | |
| TC-G 1005 | TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5) that selectively activates TGR5 over FXR (farnesoid X receptor). TC-G 1005 has been shown to increase plasma GLP-1 level and lower blood glucose level in mice. Synonyms: TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005; (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone. Grades: ≥98% by HPLC. CAS No. 1415407-60-1. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| TC HSD 21 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 = 6 and 40 nM at human and mouse 17β-HSD3, respectively) with no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors. Synonyms: TC HSD 21; TC-HSD-21; TCHSD21; TC-HSD 21; 5-[(3-Bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone. Grades: ≥99% by HPLC. CAS No. 330203-01-5. Molecular formula: C17H12BrNO3S2. Mole weight: 422.32. | |
| TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor. Grades: >98%. CAS No. 30675-13-9. Molecular formula: C9H2Cl4O2. Mole weight: 283.92. | |
| TC JL 37 | TC JL 37 is a potent and orally available inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). TC JL 37 inhibits IFNγ production in vivo in mice. Synonyms: TCJL-37; TCJL 37; TCJL37; TC JL-37; TC JL 37; TC JL37; 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1258294-34-6. Molecular formula: C17H11ClF2N4O2. Mole weight: 376.74. | |
| TC LPA5 4 | TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets. Synonyms: LPA5-IN-4; LPA5-IN4; LPA5IN4, TC-LPA5-4; 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1393814-38-4. Molecular formula: C23H23ClN2O3. Mole weight: 410.89. | |
| TC-MCH 7c | TC-MCH 7c is a potent, selective and brain-penetrating antagonist of melanin-concentrating hormone receptor 1 (MCH1R) (IC50= 5.6 nM in hMCH1R-expressing CHO cells), displaying selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Study shows that TC-MCH 7c reduces body weight in a mouse model of diet-induced obesity. Synonyms: TC-MCH 7c; TC MCH 7c; TCMCH 7c; 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone. Grades: ≥97% by HPLC. CAS No. 864756-35-4. Molecular formula: C24H25FN2O3. Mole weight: 408.47. | |
| TC Mps1 12 | TC Mps1 12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM) with selectivity for Mps1 over a panel of 95 kinases including JNK. TC Mps1 12 has been shown to inhibit the proliferation of A549 lung carcinoma cell and the growth of A549 cell xenograft in mice. Synonyms: TC-Mps1-12; TC Mps1 12; TCMps112; TC-Mps1 12; 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide. Grades: ≥99% by HPLC. CAS No. 1206170-62-8. Molecular formula: C17H20N6O. Mole weight: 324.38. | |
| TC-O9311 | TC-O9311 is a potent, selective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139) with no activity against a range of 90 diverse targets. Synonyms: 3,5-dimethoxy-benzoic acid, 2-[ (1-naphthalenylamino) carbonyl]hydrazide; TC-O 9311; TC-O-9311; TC-O9311; TCO 9311; TCO-9311; TCO9311. CAS No. 444932-31-4. Molecular formula: C20H19N3O4. Mole weight: 365.38. | |
| TCPOBOP | TCPOBOP is an constitutive androstane receptor (mCAR) agonist with EC50 value of 20 nM. But it is effective for the mouse receptor but not for human or rat CAR receptors. TCPOBOP can induce cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins. Synonyms: 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene;2,2'-(1,4-Phenylenebis(oxy))bis(3,5-dichloropyridine). Grades: 98%. CAS No. 76150-91-9. Molecular formula: C16H8Cl4N2O2. Mole weight: 402.06. | |
| TCS 2510 | TCS 2510 is a selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM) that displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM. EP4 agonist improves bone healing, provides cardio- and neuroprotection, and reduces inflammation and renal dysfunction. Synonyms: TCS 2510, TCS-2510, TCS2510; (5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone; 5-(3-hydroxy-4-phenylbut-1-enyl)-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one. Grades: ≥98% by HPLC. CAS No. 346673-06-1. Molecular formula: C21H29N5O2. Mole weight: 383.49. | |
| TCS 3035 | TCS 3035 is a GPR35 agonist (pEC50 = 5.13 and 5.86 for rat and human GPR35 orthologs, respectively). Synonyms: TCS-3035; TCS 3035; TCS3035; 2-[4-[ (Z) - (2, 4-Dioxo-5-thiazolidinylidene) methyl]phenoxyacetic acid; GPR35 Agonist, Compound 10. Grades: ≥98% by HPLC. CAS No. 871085-49-3. Molecular formula: C12H9NO5S. Mole weight: 279.27. | |
| TCS 401 | TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki = 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2, respectively). Several PTPs have been proposed to act as negative regulators of insulin signaling, suggesting PTP as a potential drug target in diabetes. Synonyms: Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, hydrochloride (1:1); Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, monohydrochloride; 2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride; TCS401; TCS-401; 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 243966-09-8. Molecular formula: C10H10N2O5S.HCl. Mole weight: 306.72. | |
| TC-S 7006 | TC-S 7006 is a potent, selective and reversible Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM) with selectivity for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. TC-S 7006 was shown to inhibit LPS-induced TNF-α secretion from primary human monocytes and attenuate acute myeloid leukemia (AML) cell proliferation in vitro. TC-S 7006 also suppresses cytolytic activity of human CD8+ cytotoxic T lymphocytes. Synonyms: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile; TC-S 7006; TC S 7006; TCS 7006; Tpl2 Kinase Inhibitor. Grades: ≥99% by HPLC. CAS No. 871307-18-5. Molecular formula: C21H14ClFN6. Mole weight: 404.83. | |
| TC SL C5 | TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor. Synonyms: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine. Grades: ≥98% by HPLC. CAS No. 827327-28-6. Molecular formula: C19H21N3O2. Mole weight: 323.4. | |
| TC-SP 14 | TC-SP 14 is a potent and selective S1P1 agonist (EC50 = 0.042 and 3.47 μM for human S1P1 and S1P3, respectively). TC-SP 14 attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Synonyms: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1257093-40-5. Molecular formula: C25H20F2N2O2S. Mole weight: 450.5. | |
| TCS PIM-1 1 | TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displaying good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). Synonyms: TCS PIM-1 1; 491871-58-0; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile; CHEMBL391586; CHEBI:86453; 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone; C18H11BrN2O2; 2obj; MFCD00276275; PIM1i; pyridone-based compound, 1; TCS PIM-11; TCS-PIM-1-1; SCHEMBL15129618; BDBM26673; EX-A308; HMS3229J17; HMS3742G19; BCP15861; 6-(5-bromo-2-hydroxy-phenyl)-2-oxo-4-phenyl-1H-pyridine-3-carbonitrile; AKOS024457365; CCG-101294; CS-2043; DB08705; AC-35434; AS-16824; HY-18086; FT-0700318; S1050; A871835; Q27097891; SC 204330; SC-204330; SC204330; 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone; 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-pyridine-3-carbonitrile; VRV. CAS No. 491871-58-0. Molecular formula: C18H11BrN2O2. Mole weight: 367.202. | |
| TCS PrP Inhibitor 13 | TCS PrP Inhibitor 13 is an antiprion agent that inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). It was also shown to cause the inhibition of PrP expression and a decrease of proliferation and survival in schwannoma cell lines. Synonyms: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one; 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one. Grades: ≥98% by HPLC. CAS No. 34320-83-7. Molecular formula: C15H11N3O3. Mole weight: 281.27. | |
| TC-T 6000 | TC-T 6000 is a potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM), displaying 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively. Synonyms: TCT6000; TCT 6000; TC-T6000. 2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol; Dipyridamole Analogue, 30. Grades: ≥98% by HPLC. CAS No. 949467-71-4. Molecular formula: C26H48N8O2. Mole weight: 504.71. | |
| TD52 | TD52 is a potent CIP2A inhibitor with increased apoptosis in HCC cells compared to erlotinib (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). CIP2A-dependent p-Akt downregulation modulates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo. Uses: Antitumor agent. Synonyms: N2,N3-bis(3-Ethynylphenyl)-2,3-quinoxalinediamine. Grades: 99%. CAS No. 1798328-24-1. Molecular formula: C24H16N4. Mole weight: 360.41. | |
| TDI-3761 | TDI-3761 is a novel alphaVbeta3 antagonist developed for osteoporosis therapy. It inhibits alphaVbeta3-dependent cell adhesion without inducing high-affinity ligand binding or exposure of the epitope for MAb AP5 (both dependent on the beta3 PSI domain). Uses: Potential osteoporosis therapy. Synonyms: TDI-3761; TDI 3761; TDI3761. | |
| TDZD-8 | TDZD-8 is a derivative of thiadiazolidine (TDZD) and acts as a non-ATP competitive inhibitor of GSK3&beta. It was shown to inhibit proliferation and self-renewal of glioblastoma stem cells. Synonyms: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-. Grades: >98%. CAS No. 327036-89-5. Molecular formula: C10H10N2O2S. Mole weight: 222.262. | |
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