BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SC 57461A | SC 57461A is a potent, selective and orally bioactive inhibitor of leukotriene A4 (LTA4) hydrolase without inhibitory effects on other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. SC 57461A inhibits LTB4 production in whole blood (IC50 = 49 nM). Synonyms: SC 57461; SC-57461; SC57461; SC 57461A; SC-57461A; SC57461A; N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride; 3-[3-(4-benzylphenoxy)propyl-methylamino]propanoic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 423169-68-0. Molecular formula: C20H25NO3.HCl. Mole weight: 363.88. |  |
| Scabioside C | Scabioside C is extracted from Pulsatilla chinensis (Bunge) Regel. Uses: Topoisomerase i inhibitors. Synonyms: Scabioside C; 17233-22-6; (4aS, 6aR, 6aS, 6bR, 8aR, 9R, 10S, 12aR, 14bS)-10-[(2S, 3R, 4R, 5S)-3, 4-dihydroxy-5-[(2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-9-(hydroxymethyl)-2, 2, 6a, 6b, 9, 12a-hexamethyl-1, 3, 4, 5, 6, 6a, 7, 8, 8a, 10, 11, 12, 13, 14b-tetradecahydropicene-4a-carboxylic acid; Leontoside B; CHEMBL466974; AKOS040760693; HY-107309; CS-0027942. Grades: >98%. CAS No. 17233-22-6. Molecular formula: C41H66O13. Mole weight: 767. | |
| (S)-CCG-1423 | (S)-CCG-1423 is a stereoisomer of CCG-1423, a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). Synonyms: (S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide. Grades: ≥98%. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.8. | |
| (S)-CFI-401870 | CFI-401870, an azabicyclo derivative, has been found to be a TTK inhibitor that could be significant in anticancer studies. IC50 < 10 nM. Synonyms: CFI-401870; CFI 401870; CFI401870; N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide. Grades: 98%. CAS No. 1599460-95-3. Molecular formula: C30H31N5O2. Mole weight: 493.61. | |
| SCH 202676 hydrobromide | SCH 202676 hydrobromide is a reversible inhibitor of agonist and antagonist binding to G-protein-coupled receptors. It inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 = 0.1-1.8 μM). Synonyms: SCH 202676 hydrobromide; SCH202676 hydrobromide; SCH-202676 hydrobromide; N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide. Grades: ≥99% by HPLC. CAS No. 265980-25-4. Molecular formula: C15H13N3S.HBr. Mole weight: 348.26. | |
| SCH-51344 | SCH-51344, a pyrazoloquinolin derivative, has been found to be a MTH1 inhibitor that could be significant in anticancer studies through restraining Ras-induced malignant transformation. Kd = 49 nM. Synonyms: SCH-51344; SCH 51344; SCH51344. Ras/Rac Transformation Blocker, SCH 51344; SCH-51344; 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline; 2-(2-((6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino)ethoxy)ethanol; 2-{2-[(6-methoxy-3-methyl-1H-pyrazo. Grades: 98%. CAS No. 171927-40-5. Molecular formula: C16H20N4O3. Mole weight: 316.36. | |
| SCH 58261 | SCH 58261 is a potent and selective antagonist of adenosine A2A receptor, displaying neuroprotective activity. Uses: Adenosine a2 receptor antagonists. Synonyms: SCH-58261; SCH 58261; SCH58261. 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine. Grades: 98%. CAS No. 160098-96-4. Molecular formula: C18H15N7O. Mole weight: 345.366. | |
| SCH772984 | SCH772984 is a potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild-type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non-BRAF mutant melanoma or in BRAF-mutant melanoma with innate or acquired resistance, alone or in combination with BRAF inhibitors. Synonyms: SCH-772984; SCH 772984; (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide. Grades: 95%. CAS No. 942183-80-4. Molecular formula: C33H33N9O2. Mole weight: 587.688. | |
| Schisandrone | Schisandrone is extracted from the fruits of Schisandra sphenanthera. Synonyms: Arisantetralone C. Grades: >98%. CAS No. 98619-25-1. Molecular formula: C21H24O5. Mole weight: 356.4. | |
| Schisanhenol B | antioxidant. Uses: Antioxidant. Synonyms: Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer; schisanhenol B. Grades: >98%. CAS No. 102681-52-7. Molecular formula: C22H26O6. Mole weight: 386.444. | |
| Schisantherin B | Schisantherin B shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Uses: Hepatoprotection. Synonyms: SCHISANTHERIN B; 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)-; SCHISANTHERIN B 98.0% BY HPLC; GOMISINB; (5S)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7β-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5α,6β-diol 5-[(Z)-2-methyl-2-butenoate]; (5S)-6α,7β-Dimethyl-1,2,3,12-tetramethoxy-10,11-methylenedioxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β-diol 5-[(Z)-2-methyl-2-butenoate]; 2-Butenoic acid, 2-methyl-, (5S,6S,7S,13as)-5,6,7,13A-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-F][1,3]benzodioxol-5-yl ester, (2Z)-; (2Z)-2-Methyl-2-butenoic acid(5S,6S,7S,13aS)-5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester. Grades: >98%. CAS No. 58546-55-7. Molecular formula: C28H34O9. Mole weight: 514.56. | |
| Schisantherin E | Source from the seeds of Schisandra chinensis (Turcz.) Baill, shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Uses: Lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. Synonyms: (6S,7S,8S)-5,6,7,8-Tetrahydro-1,2,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-3,7,8-triol 8-benzoate. Grades: ≥98%. CAS No. 64917-83-5. Molecular formula: C30H34O9. Mole weight: 538.59. | |
| Schisanwilsonin H | Schisanwilsonin H is a lignan found in the fruits of Schisandra wilsoniana. Synonyms: Arisanschinin K; Schisantherrin A. Grades: >98%. CAS No. 1181216-83-0. Molecular formula: C30H32O9. Mole weight: 536.577. | |
| Schisanwilsonin I | Schisanwilsonin I is a lignan found in the fruits of Schisandra wilsoniana. Synonyms: 2-Butenoic acid, 2-methyl-, (5S,6R,7S,13aS)-5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester, (2E)-. Grades: >98%. CAS No. 1181216-84-1. Molecular formula: C28H34O9. Mole weight: 514.571. | |
| Schizophyllan | Schizophyllan is an immunostimulant commonly used in cancer treatment in combination with other antineoplastic drugs. Synonyms: Sonifilan; Sizofiran; SPG; β(1-3, 1-6)-glucan. Grades: 90%. CAS No. 9050-67-3. | |
| SCR7 pyrazine | SCR7 pyrazine is a DNA Ligase IV inhibitor. SCR7 pyrazine has been shown to potentiate CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold, and inhibits nonhomologous end-joining (NHEJ). Synonyms: SCR7 pyrazine; SCR-7 pyrazine; SCR 7 pyrazine; 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 2-mercapto-6,7-diphenylpteridin-4-ol; 6,7-diphenyl-2-sulfanylpteridin-4-ol. Grades: ≥98% by HPLC. CAS No. 14892-97-8. Molecular formula: C18H12N4OS. Mole weight: 332.38. | |
| SD-208 | SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. Synonyms: SD-208; SD 208; SD208; TGF-β RI Kinase Inhibitor V. Grades: >98%. CAS No. 627536-09-8. Molecular formula: C17H10ClFN6. Mole weight: 352.75. | |
| (S)-Dolaphenine hydrochloride | (S)-Dolaphenine hydrochloride is a useful componet for compound synthesis. Synonyms: (S)-Dolaphenine hydrochloride. Grades: >98%. CAS No. 135383-60-7. Molecular formula: C11H13ClN2S. Mole weight: 240.75. | |
| SDZ285-428 | SDZ285-428 is a CYP24A1 inhibitor. Synonyms: SDZ285 428; 4-(4-chlorophenyl)-N-(2-imidazol-1-yl-2-phenylethyl)benzamide; NVP-VID-400; NVP VID 400; NVP-VID-400; NVP-VID 400; NVP-VID400; SDZ285428; SDZ 285428; SDZ-285428; SDZ285-428; SDZ 285-428; SDZ-285-428. CAS No. 174262-13-6. Molecular formula: C24H20ClN3O. Mole weight: 401,894. | |
| SDZ NKT 343 | SDZ NKT 343 is a highly selective human tachykinin NK1 receptor antagonist (IC50 = 0.62 and 451 nM for human and rat receptors, respectively), displaying > 130-fold selectivity over human NK2 and NK3 receptors. SDZ NKT 343 was shown to antagonize SP-induced Ca2+ efflux in vitro and inhibit mechanical hyperalgesia in vivo. Uses: Neurokinin-1 receptor antagonists. Synonyms: 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide. Grades: ≥98% by HPLC. CAS No. 180046-99-5. Molecular formula: C33H33N5O5. Mole weight: 579.65. | |
| Sebetralstat | Sebetralstatum is a kallikrein inhibitor. Synonyms: N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1(2H)-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide. Grades: >98%. CAS No. 1933514-13-6. Molecular formula: C26H26FN5O4. Mole weight: 491.5. | |
| Selank | Selank is a synthetic analogue of human tuftsin and acts as a nootropic, anxiolytic peptide. Synonyms: Thr-Lys-Pro-Arg-Pro-Gly-Pro; Selanc. Grades: 98%. CAS No. 129954-34-3. Molecular formula: C33H57N11O9. Mole weight: 751.9. | |
| Selonsertib | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Synonyms: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide; GS-4997; GS4997; GS 4997. Grades: ≥98%. CAS No. 1448428-04-3. Molecular formula: C24H24FN7O. Mole weight: 445.5. | |
| Selpercatinib | Selpercatinib is a selective RET inhibitor with antineoplastic activity. It inhibits proliferation of cancer cells containing RET mutations or gene fusions. It is indicated for the treatment of non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and other thyroid cancer tumors. Synonyms: LOXO-292; LOXO292; LOXO 292; ARRY-192; ARRY192; ARRY 192. CAS No. 2152628-33-4. Molecular formula: C29H31N7O3. Mole weight: 525.6. | |
| Semaglutide intermediate | Semaglutide intermediate is an intermediate of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Synonyms: (S)-21,39-di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate; 17- ( (S) -1-tert-Butoxycarbonyl-3-{2-[2- ({2-[2- (2, 5-dioxopyrrolidin-1-yloxycarbonylmethoxy) ethoxy]ethylcarbamoyl}methoxy) ethoxy]-ethylcarbamoyl}propylcarbamoyl) heptadecanoic acid tert-butyl ester; Octadecanoic acid, 18-[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-22-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4,13,22-trioxo-8,11,17,20-tetraoxa-5,14-diazadocos-1-yl]amino]-18-oxo-, 1,1-dimethylethyl ester; Bis(2-methyl-2-propanyl) (22S)-1-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazatetracontane-22,40-dicarboxylate; tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. Grades: ≥95%. CAS No. 1118767-15-9. Molecular formula: C47H82N4O15. Mole weight: 943.19. | |
| Semaglutide intermediate P29 | An intermediate of Semaglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. Synonyms: Semaglutide [sequence (9-37)]; L-α-Glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: ≥95%. CAS No. 1169630-82-3. Molecular formula: C142H216N38O45. Mole weight: 3175.47. | |
| Semapimod hydrochloride | Semapimod (INN), formerly known as CNI-1493, is a cytokine inhibitor. Semapimod is an investigational new drug which has anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial properties. Structurally, semapimod is synthetic guanylhydrazone mitogen-activated protein kinase blocker, as a potential treatment for Crohn's disease and other inflammatory conditions. Clinical trials of Semapimod started in 2001. Synonyms: CNI-1493; CNI 1493; CNI1493; AXD455; AXD 455; AXD-455; AIDS121302; AIDS-121302; AIDS 121302. Grades: >98%. CAS No. 164301-51-3. Molecular formula: C34H56Cl4N18O2. Mole weight: 890.746. | |
| Sepantronium | Sepantronium, also known as YM-155, is a small-molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Uses: For research used only. Synonyms: YM155; YM 155; YM-155; Sepantronium bromide. Grades: >98%. CAS No. 781661-94-7. Molecular formula: C20H19BrN4O3. Mole weight: 443.29386. | |
| Sephin 1 | Sephin 1 is a selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin 1 selectively disrupted the PPP1R15A-PP1c complex, thus prolonging eIF2α phosphorylation after stress, delaying translation recovery, and attenuated expression of stress genes such as the pro-apoptotic protein CHOP. In mice, Sephin 1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases. Uses: Potential treatment of protein misfolding disease. Synonyms: Sephin1; Sephin-1. Grades: 99%. CAS No. 951441-04-6. Molecular formula: C8H9ClN4. Mole weight: 196.64. | |
| Seratrodast | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: (+/-)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic Acid; AA-2414; Benzeneheptanoic acid, ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-; Benzeneheptanoic acid, ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-, (±)-; ζ-(2,4,5-Trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)benzeneheptanoic acid; (±)-2,4,5-Trimethyl-3,6-dioxo-ζ-phenyl-1,4-cyclohexadiene-1-heptanoic acid; 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid; A 73001; AA 2414; AA2414; Abbott 73001; ABT 001; Bronica; Seratodrast. Grades: >98%. CAS No. 112665-43-7. Molecular formula: C22H26O4. Mole weight: 354.44. | |
| Sertindole | Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Synonyms: Sertindole;SerLect; Serdolect; Sertindol; Sertindolum; Lu 23-174; Lu-23-174; Serdolect; Serlect; sertindole; sertindole hydrochloride. Grades: >98%. CAS No. 106516-24-9. Molecular formula: C24H26ClFN4O. Mole weight: 440.94. | |
| Sertraline 2,3-Dichloro Ketone Impurity | An impurity of sertraline. Sertraline is a selective serotonin reuptake inhibitor (SSRI) for the treatment of depression. Synonyms: 4-(2,3-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone; rac 4-(2,3-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone. Grades: > 95%. CAS No. 152448-80-1. Molecular formula: C16H12Cl2O. Mole weight: 291.17. | |
| sesamolin | Sesamin and sesamolin have been demonstrated to possess several bioactivities beneficial for human health. Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated when they were pretreated with sesamin or sesamolin. The neuroprotective effect of sesamin and sesamolin was also observed in vivo using gerbils subjected to a focal cerebral ischemia induced by occlusion of the right common carotid artery and the right middle cerebral artery. Synonyms: (+)-5-[(1S,3aβ,4R,6aβ)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole; (+)-5-[(1S,3aβ,4R,6aβ)-4-(1,3-Benzodioxole-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole; 5-[(1S,3aβ,4β,6aβ)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole; 5-[(1S,3aβ,4β,6aβ)-4-(1,3-Benzodioxole-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole; 5-[(1S,3aR,4R,6aR)-4-(1,3-benzodioxol-5-yloxy)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-1-yl]-1,3-benzodioxole; 5-[(1S,3aR,4R,6aR)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole. Grades: >98%. CAS No. 526-07-8. Molecular formula: C20H18O7. Mole weight: 370.36. | |
| Setipiprant | Setipiprant is a potent, orally available and selective CRTH2 antagonist, which is a G protein-coupled receptor for PGD2. It may be a promising target for the treatment of allergic disorders. It was well tolerated and reduced both the allergen-induced LAR and the associated AHR in allergic asthmatics at multiple oral doses. It is a drug originally developed by Actelion, but it failed to show sufficient advantages and was discontinued from further development in this application. Later it was developed as a novel treatment for baldness by Kythera. Uses: Setipiprant may be a promising target for the treatment of allergic disorders. Synonyms: ACT-129968; ACT 129968; ACT129968; 2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid;ACT129968;2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid;8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid; KYTH-105; KYTH105; KYTH 105. Grades: >98 %. CAS No. 866460-33-5. Molecular formula: C24H19FN2O3. Mole weight: 402.42. | |
| Sevelamer | Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease. It consists of polyallylamine that is crosslinked with epichlorohydrin. Uses: Chelating agents. Synonyms: Sevelamer; 52757-95-6; 2-(chloromethyl)oxirane; prop-2-en-1-amine; 2-Propen-1-amine, polymer with (chloromethyl)oxiraneOTHER CA INDEX NAMES:Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine; Sevelamer anhydrous; Sevelamer (INN); 2-(chloromethyl)oxirane; prop-2-en-1-amine; 1392212-84-8; SCHEMBL726092; 3-(Trifluoromethoxy)cinnamicacid; CHEMBL1201798; ZNSIZMQNQCNRBW-UHFFFAOYSA-N; DB00658; NCGC00522026-01; Sevelamer Hydrochloride (Technical Grade); D08512; EN300-25310384. Grades: >98%. CAS No. 52757-95-6. Molecular formula: C6H12ClNO. Mole weight: 149.62. | |
| SEW 2871 | SEW 2871 is a potent, cell-permeable and selective sphingosine-1-phosphate type 1 receptor agonist (EC50= 13 nM). SEW 2871 suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole; SEW2871; SEW2871; SEW2871. Grades: >98%. CAS No. 256414-75-2. Molecular formula: C20H16N2OS. Mole weight: 332.419. | |
| Sfllrnpndkyepf | Cas No. 137339-65-2. | |
| SGC-CBP30 | SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to Rubinstein-Taybi syndrome (RTS), characterised by growth retardation, facial abnormalities, organ abnormalities, mental retardation and altered tumor susceptibility. Synonyms: SGCCBP30; SGC CBP30. Grades: 0.98. CAS No. 1613695-14-9. Molecular formula: C28H33ClN4O3. Mole weight: 509.03962. | |
| SGI-1776 | SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies. Synonyms: SGI 1776; SGI 1776. Grades: >98%. CAS No. 1025065-69-3. Molecular formula: C20H22F3N5O. Mole weight: 405.425. | |
| SGI-7079 | This active molecular is a selective Axl inhibitor and Axl is a potential therapeutic target for overcoming EGFR inhibitor resistance. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells. IC50 value for SUM149 is 0.43 μM, 0.16 μM for KPL-4. It inhibited Axl activation in the presence of exogenous Gas6 ligand effectively. It will be a drug candidate as a anticancer agent. Uses: Anti-cancer. Synonyms: SGI-7079; SGI 7079; SGI7079. 2-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile. CAS No. 1239875-86-5. Molecular formula: C26H26FN7. Mole weight: 455.53. | |
| SH-4-54 | SH-4-54 is a potent STAT inhibitor with KD values of 300 nM and 464 nM for STAT3 and STAT5, respectively. It potently kills glioblastoma brain cancer stem cells (BTSCs). Synonyms: 4-[ (4-cyclohexylphenyl) methyl-[2-[methyl- (2, 3, 4, 5, 6-pentafluorophenyl) sulfonylamino]acetyl]amino]benzoic acid. Grades: >98%. CAS No. 1456632-40-8. Molecular formula: C29H27F5N2O5S. Mole weight: 610.59. | |
| SHA 68 | SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist (IC50 = 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants, respectively) that displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors. Synonyms: SHA 68; SHA68; SHA-68; N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide. Grades: ≥98% by HPLC. CAS No. 847553-89-3. Molecular formula: C26H24FN3O3. Mole weight: 445.49. | |
| Shancigusin I | Shancigusin I is found in Bletilla striata. Grades: > 95%. CAS No. 1435488-35-9. Molecular formula: C28H34O14. Mole weight: 594.56. | |
| SHIP 2a | SHIP 2a is a cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM). SHIP 2a was demonstrated ability to suppress H2S production in mouse aorta homogenates and L-cysteine-induced relaxation of rat aortic rings ex vivo. Synonyms: (R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide. Grades: ≥98% by HPLC. Molecular formula: C7H8N2O2S. Mole weight: 184.22. | |
| (S)-homo-β-alanine | (S)-Homo-β-alanine, an amino acid occurring naturally, acts as an intermediary in thymine metabolism. Its potential to regulate oxidative stress and inflammation marks it as a prospective treatment for cardiovascular disease and hypertension. Also, research suggests its involvement in the synthesis of neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Synonyms: (S)-beta-homoalanine. Grades: 95%. CAS No. 3775-72-2. Molecular formula: C4H9NO2. Mole weight: 103.11. | |
| SHP099 dihydrochloride | SHP099 is a potent and small-molecule inhibitor that has selectivity for SHP2 over SHP1 (IC50?=?0.071?μM), which is orally bioavailable. In xenograft models, SHP099 exhibited an inhibitory effect on dose-dependent pathway and antineoplastic activity. It also plays a role in the programmed cell death pathway (PD-1/PD-L1). Synonyms: SHP099 dihydrochloride; SHP 099 dihydrochloride; SHP-099 dihydrochloride; KS-00000TTA; AKOS030632792; 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride. Grades: 99.70 %. Molecular formula: C16H21Cl4N5. Mole weight: 425.18. | |
| SI-2 | SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability. Synonyms: Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-; (1E)-1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone; 2H-Benzimidazol-2-one, 1,3-dihydro-1-methyl-, [(2E)-1-(2-pyridinyl)ethylidene]hydrazone; EPH 116; (E)-SI-2. Grades: ≥98%. CAS No. 380537-35-9. Molecular formula: C15H15N5. Mole weight: 265.31. | |
| SI-2 hydrochloride | SI-2 hydrochloride is a potent and orally available steroid receptor coactivator 3 (SRC-3) inhibitor. SI-2 has been shown to decrease SRC1, SRC2 and SRC3 levels in breast cancer cell lines. It inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Synonyms: SI-2 hydrochloride; SI 2 hydrochloride; SI2 hydrochloride;1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride; 1-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C15H15N5.HCl. Mole weight: 301.78. | |
| SID 3712249 | SID 3712249 is an biogenesis of microRNA-544 (miR-544) inhibitor caused apoptosis in triple negative breast cancer cells. Uses: Mir-544 inhibitor. Synonyms: MiR-544 Inhibitor 1; SID 3712249 , MLS 000054131, SID3712249 , MLS000054131, SID-3712249 , MLS-000054131,1,8-Diamino-3,6-di(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile. Grades: ≥95%. CAS No. 522606-67-3. Molecular formula: C17H21N7. Mole weight: 323.4. | |
| SID 7969543 | SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 = 0.76, >33 and >33 μM at SF-1, RORα and VP16, respectively). It also inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM). Synonyms: SID 7969543; SID7969543; SID-7969543; Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate. Grades: ≥98% by HPLC. CAS No. 868224-64-0. Molecular formula: C24H24N2O7. Mole weight: 452.46. | |
| Sildenafil Impurity A | Cas No. 1391053-95-4. | |
| Silidianin | Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger. Synonyms: Silidianine; (+)-2,3α,3aα,7a-Tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-3,6-methanobenzofuran-7(6αH)-one; [3R-[3α, 3aβ, 4(2R*, 3R*), 6α, 7aβ, 8R*]]-4-(3, 4-Dihydro-3, 5, 7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2, 3, 3a, 7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3, 6-methanobenzofuran-7(6H)-one; (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one. Grades: >98%. CAS No. 29782-68-1. Molecular formula: C25H22O10. Mole weight: 482.4. | |
| Silmitasertib | Silmitasertib is an orally bioavailable inhibitor of CK2 with potential antineoplastic activity. It inhibits proliferation in cancer cell lines overexpressing CK2. It suppresses survival and induces apoptosis of cancer stem cells including glioblastomas and acute myeloid leukemia cells. Synonyms: CX-4945; CX 4945; 5-((3-Chlorophenyl)amino)benzo[c][2, 6]naphthyridine-8-carboxylic acid. Grades: >98%. CAS No. 1009820-21-6. Molecular formula: C19H12ClN3O2. Mole weight: 349.774. | |
| Silybin | Cas No. 22888-70-6. | |
| Silybin B | An isomer of Silybin. Silybin, extracted from Silybum, is the major active constituent of silymarin. Uses: Antineoplastic agents, phytogenic. Synonyms: (2R,3R)-2-[(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.; NSC 227190; Silibinin B; Silybin a1. Grades: > 95%. CAS No. 142797-34-0. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Silychristin | Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic flavonolignan. Synonyms: (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one; 3R-[3α, 3aβ, 4(2R*, 3R*), 6α, 7aβ, 8R*]]-4-(3, 4-Dihydro-3, 5, 7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2, 3, 3a, 7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3, 6-methanobenzofuran-7(6H)-one; (+)-2,3α,3aα,7a-Tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-3,6-methanobenzofuran-7(6αH)-one; Silidianin; Silidianine; Silydianin. Grades: >98%. CAS No. 33889-69-9. Molecular formula: C25H22O10. Mole weight: 482.4. | |
| Simufilam | Simufilam is a filamin A altered conformations binder. Synonyms: simufilamum; PTI125; PTI 125; PTI-125; 8-Methyl-1-(phenylmethyl)-1,4,8-triazaspiro[4.5]decan-2-one. Grades: >98%. CAS No. 1224591-33-6. Molecular formula: C15H21N3O. Mole weight: 259.35. | |
| Simvastatin 4'-Methyl Ether | Cas No. 864357-88-0. | |
| Simvastatin EP Impurity B | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: Acetyl simvastatin; 4'-Acetyl Simvastatin; Simvastatin Acetate; Simvastatin acetate ester; Simvastatin USP Related Compound B. Grades: 95%. CAS No. 145576-25-6. Molecular formula: C27H40O6. Mole weight: 460.62. | |
| Simvastatin EP Impurity C | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: Simvastatin USP Related Compound C; 2,3-Anhydro Simvastatin; Dehydro Simvastatin; Anhydro simvastatin. Grades: 95%. CAS No. 210980-68-0. Molecular formula: C25H36O4. Mole weight: 400.56. | |
| Simvastatin EP Impurity F | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: Simvastatin USP Related Compound F; epi-Lovastatin; Lovastatin epimer; (2R)-2-Methylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester. Grades: 95%. CAS No. 79952-44-6. Molecular formula: C24H36O5. Mole weight: 404.55. | |
| Simvastatin EP Impurity I | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: 2'-Ethyl Simvastatin. CAS No. 79902-42-4. Molecular formula: C23H34O5. Mole weight: 390.51. | |
| Simvastatin hydroxy acid sodium salt | A metabolite of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic Acid Monosodium Salt; [1S-[1α(βS*, δS*), 2α, 6β, 8β, 8aα]]-8-(2, 2-Dimethyl-1-oxobutoxy)-1, 2, 6, 7, 8, 8a-hexahydro-β, δ-dihydroxy-2, 6-dimethyl-1-naphthaleneheptanoic Acid Monosodium Salt; Simvastatin Sodium; Simvastatin Sodium Salt. Grades: > 95%. CAS No. 101314-97-0. Molecular formula: C25H39O6. Na. Mole weight: 435.59 22.99. | |
| Simvastatin Impurity D | Cas No. 476305-24-5. | |
| Simvastatin Impurity H | Cas No. 79952-42-4. | |
| Sinapine | Sinapine is an alkaloid isolated from cruciferous species with antioxidant and radio-protective activities. Synonyms: Sinapoylcholine; O-sinapoylcholine. Grades: 98%. CAS No. 18696-26-9. Molecular formula: C16H24NO5+. Mole weight: 310.36. | |
| Sincalide | It is a synthetically-prepared C-terminal octapeptide of cholecystokinin.Sincalide (INN) is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin. Synonyms: Sincalide. Grades: >98%. CAS No. 25126-32-3. Molecular formula: C49H62N10O16S3. Mole weight: 1143.29. | |
| Siramesine hydrochloride | Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with potent anticancer activity in vivo. It was originally devevloped for treating depressant. Synonyms: Siramesine (hydrochloride); Siramesine HCl; Lu-28-179; Lu 28-179; Lu28-179; Lu-28179; Lu 28179; Lu28179. CAS No. 224177-60-0. Molecular formula: C30H32ClFN2O. Mole weight: 491.04. | |
| SIS3 HCl | SIS3 is a potent and specific inhibitor of Smad3 via inhibiting the effects of TGF-β1. SIS3 inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation with no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. It inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Synonyms: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride. Grades: >98%. CAS No. 521984-48-5. Molecular formula: C28H27N3O3.HCl. Mole weight: 489.99. | |
| Sitagliptin EP Impurity A Phosphate | Sitagliptin EP Impurity A Phosphate is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin S-Isomer Phosphate; ent-Sitagliptin Phosphate; (S)-Sitagliptin Phosphate; 7-[(3S)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate. Grades: >95%. CAS No. 823817-58-9. Molecular formula: C16H15F6N5O.H3PO4. Mole weight: 505.31. | |
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