BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Rbin-2 | Rbin-2 (ribozinoindole-2) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 14 nM in wild-type cells). Rbin-2 can be used as a chemical probe for the eukaryotic ribosome assembly. Uses: Chemical probe for the eukaryotic ribosome assembly. Synonyms: Rbin-2; Rbin 2; Rbin2; 7-Bromo-2-(2-methyl-allylsulfanyl)-9H-1,3,4,9-tetraaza-fluorene. Grades: 98%. CAS No. 2032282-97-4. Molecular formula: C13H11BrN4S. Mole weight: 335.22. |  |
| (R)-Bromoenol lactone | (R)-Bromoenol lactone is an irreversible inhibitor of iPLA2&gamma. Synonyms: (R)-BEL; (3R)-6-Ethylidene-3-(naphthalen-1-yl)oxan-2-one; 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one. Grades: ≥98%. CAS No. 478288-90-3. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| (R)-CCG-1423 | (R)-CCG-1423 is a stereoisomer of CCG-1423, a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). Synonyms: (R)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide. Grades: ≥98%. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.8. | |
| (R)-CE3F4 | (R)-CE3F4 is an Epac inhibitor (IC50 = 4.2 and 44 μM for Epac1 and Epac2(B), respectively), suppressing the activation of Epac by cAMP. Synonyms: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde. Grades: ≥98% by HPLC. CAS No. 1593478-56-8. Molecular formula: C11H10Br2FNO. Mole weight: 351.01. | |
| (R)-Citalopram Oxalate | (R)-Citalopram Oxalate is an inhibitor of serotonin (5-HT) uptake. It shows antidepressant activity. Synonyms: 1-(3-Dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile Oxalate. Grades: > 95%. CAS No. 219861-53-7. Molecular formula: C22H23FN2O5. Mole weight: 414.43. | |
| RCM 1 | RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Study has shown that it inhibited goblet cell metaplasia and excessive mucus production in mice after exposure to allergens. Synonyms: RCM1; RCM 1; 2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 339163-65-4. Molecular formula: C20H12N2OS4. Mole weight: 424.58. | |
| (R)-Coclaurine | (R)-Coclaurine is a nicotinic acetylcholine receptor antagonist isolated from a variety of plant sources. Synonyms: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-, (1R)-. CAS No. 2196-60-3. Molecular formula: C17H19NO3. Mole weight: 285.34. | |
| Rebaudioside D | Rebaudioside D is extracted from the leaves of Stevia rebaudiana Bertoni. It is a potential sweetener. It showed similar stability when exposed to simulated stomach and small intestine fluids, with susceptibility to hydrolytic degradation by enteric bacteria collected from the cecum. Synonyms: (4a)-13-[(O-b-D-Glucopyranosyl-(1,2)-O-[b-D-glucopyranosyl-(1,3)]-b-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid 2-O-b-D-glucopyranosyl-b-D-glucopyranosyl ester; Reb D. Grades: >98%. CAS No. 63279-13-0. Molecular formula: C50H80O28. Mole weight: 1129.15. | |
| Rebaudioside I | Rebaudioside I, a plant-derived non-caloric sweetener extracted from Stevia rebaudiana leaves, has been widely adopted in food and beverage industries as a sugar supplement. Beyond its sweetness, this compound demonstrates tremendous potential for managing type 2 diabetes, by enhancing insulin secretion and improving glucose tolerance. Evidence also suggests that rebaudioside I may possess both anti-inflammatory and anti-tumor properties, making it a promising candidate for therapeutic applications. Synonyms: KAUR-16-EN-18-oic acid, 13-((o-beta-D-glucopyranosyl-(1->2)-O-(beta-D-glucopyranosyl-(1->3))-beta-D-glucopyranosyl)oxy)-, 3-o-beta-D-glucopyranosyl-beta-D-glucopyranosyl ester, (4alpha)-. CAS No. 1220616-34-1. Molecular formula: C50H80O28. Mole weight: 1129.15. | |
| Rebaudioside M | Rebaudioside M is a natural sweetener extracted from the stevia plant. It is commonly used as a substitute for sugar in various food and beverage products due to its high sweetness and low calorie content. Additionally, studies have shown that rebaudioside M may have potential applications in the treatment of diabetes and obesity due to its ability to regulate blood sugar levels and improve insulin sensitivity. Synonyms: 13-[(O-b-D-Glucopyranosyl-(1,2)-O-[b-D-glucopyranosyl-(1,3)]-b-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid (4)-O-b-D-glucopyranosyl-(1,2)-O-[b-D-glucopyranosyl-(1,3)]-b-D-glucopyranosyl ester; Reb M; Reb X. CAS No. 1220616-44-3. Molecular formula: C56H90O33. Mole weight: 1291.29. | |
| Rebeprazole sulfone N-oxide | An impurity of Rabeprazole. Rabeprazole is a proton pump inhibitor as an antiulcer drug. Synonyms: 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-1-oxido-2-pyridinyl]methyl]sulfonyl]-. Grades: 95%. CAS No. 924663-37-6. Molecular formula: C18H21N3O5S. Mole weight: 391.44. | |
| Redaporfin | This active molecular can be applicated as a photosensitizer for PDT (Photodynamic Therapy) of cancer. Redaporfin showed a great efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Tumour can be regressed in 83% of the mice when given a treatment of Vascular-PDT with 1.5 mg/kg Redaporfin and a light dose of 74 J/cm². Now Redaporfin is in Phase I/II for treatment of head and neck cancer under the development of Luzitin. Uses: Head and neck cancer. Synonyms: F-2BMet; LUZ-11; F2BMet; LUZ11; F 2BMet; LUZ 11; 3,3',3'',3'''-(7H,8H,17H,18H-porphyrin-5,10,15,20-tetrayl)tetrakis(2,4-difluoro-N-methylbenzenesulfonamide. Grades: 98%. CAS No. 1224104-08-8. Molecular formula: C48H38F8N8O8S4. Mole weight: 1135.11. | |
| Relacorilant | Relacorilant is an antagonist of glucocorticoid receptor which is under development for the treatment of Cushing's syndrome. CAS No. 1496510-51-0. Molecular formula: C27H22F4N6O3S. Mole weight: 586.6. | |
| Relamorelin | Relamorelin is a synthetic, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide and an analogue of ghrelin. It produces increases in plasma growth hormone, prolactin, and cortisol levels, and increases appetite in humans. It is under development by Rhythm Pharmaceuticals and is in phase II clinical trials. Uses: Relamorelin is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. Synonyms: BIM28131; BIM 28131; BIM-28131; BIM-28163; BIM 28163; BIM28163; RM131; RM-131; RM 131; Relamorelin;N-((R)-3-(benzo[b]thiophen-3-yl)-1-(((R)-1-(((S)-1-((4-carbamoylpiperidin-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)piperidine-3-carboxamide;4. Grades: 98%. CAS No. 661472-41-9. Molecular formula: C43H50N8O5S. Mole weight: 790.98. | |
| Relugolix | Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. By preventing LH-RH from binding with the LH-RH receptor in the anterior pituitary gland and suppressing the secretion of luteinizing hormone (LH) and follicle stimulation hormone (FSH) from the anterior pituitary gland, TAK-385 controls the effect of LH and FSH on the ovary, reduces the level of estrogen in blood, which is known to be associated with the development of endometriosis and uterine fibroids, and is expected to improve the symptoms of these disorders. Uses: Androgen antagonists. Synonyms: TAK-385; N-[4-[1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxyurea; Orgovyx; RVT 601; 1-{4-[1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea. Grades: ≥95%. CAS No. 737789-87-6. Molecular formula: C29H27F2N7O5S. Mole weight: 623.63. | |
| Remeglurant | Remeglurant is a selective Metabotropic glutamate receptor 5 antagonist originated by Merz Pharmaceuticals. Phase-I for Drug-induced dyskinesia in USA was on-going. Uses: Drug-induced dyskinesia. Synonyms: UNII-Y7H8880HMD;(R)-(6-bromopyrazolo[1,5-a]pyrimidin-2-yl)(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone. Grades: 98%. CAS No. 1309783-00-3. Molecular formula: C17H15BrN4O. Mole weight: 371.24. | |
| Remikiren | Remikiren is a renin inhibitor originated by Roche in 1996. But clinical trials for the treatment of Heart failure and Hypertension was discontinued. Uses: Heart failure; hypertension. Synonyms: (αS)-N-[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[(2S)-2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-1H-imidazole-5-propanamide; [1S-[1R*[R*(R*)],2S*,3R*]]-N-[1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-α-[[2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-1H-imidazole-4-propanamide; Ro 42-5892; Ro 42-5892/001. Grades: 95%. CAS No. 126222-34-2. Molecular formula: C33H50N4O6S. Mole weight: 630.84. | |
| Remodelin hydrobromide | Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Synonyms: Remodelin HBr; Remodelin Hydrobromide. Grades: >98%. CAS No. 1622921-15-6. Molecular formula: C15H15BrN4S. Mole weight: 363.28. | |
| Rencofilstat | Rencofilstat is a cyclophilin inhibitor. Synonyms: CRV431; CRV-431; CRV 431; 6-[(2S,3R,4R)-10-acetamido-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)cyclosporin A; 1,11-anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R)-10-acetamido-3-hydroxy-N,4-dimethyl-L-2-aminodecanoyl-L-2-aminobutanoyl-N-methyl-D-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]; N-((7R, 8R)-8-((2S, 5S, 8R, 11S, 14S, 17S, 20S, 23R, 26S, 29S, 32S)-5-Ethyl-11, 17, 26, 29-tetraisobutyl-14, 32-diisopropyl-1, 7, 8, 10, 16, 20, 23, 25, 28, 31-decamethyl-3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33-undecaoxo-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecaazacyclotritriacontan-2-yl)-8-hydroxy-7-methyloctyl)acetamide. CAS No. 1383420-08-3. Molecular formula: C67H122N12O13. Mole weight: 1303.8. | |
| Renzapride hydrochloride | Renzapride is a gastroprokinetic agent and antiemetic which acts as a 5-HT4 full agonist and 5-HT3 antagonist. Synonyms: ATL-1251; Renzapride HCl; 4-Amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide hydrochloride. CAS No. 109872-41-5. Molecular formula: C16H23Cl2N3O2. Mole weight: 360.279. | |
| REP 3123 dihydrochloride | REP 3123 dihydrochloride is a selective inhibitor of methionyl-tRNA synthetase (MetRS) used as an antibiotic for the treatment of Clostridium difficile infection (CDI). Uses: Antibiotic, the treatment of clostridium difficile infection (cdi). Synonyms: CRS3123 2HCl; REP-3123 Dihydrochloride; REP 3123 Dihydrochloride; REP3123 Dihydrochloride 5-[(3-{[(4R)-6,8-Dibromo-3,4-dihydro-2H-chromen-4-yl]amino}propyl)amino]thieno[3,2-b]pyridin-7(4H)-one dihydrochloride. Grades: 99%. CAS No. 1013915-99-5. Molecular formula: C19H19Br2N3O2S.2HCl. Mole weight: 586.17. | |
| Repaglinide Impurity E | An impurity of Repaglinide, an antidiabetic drug. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus. Uses: Hypoglycemic agents. Synonyms: 2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic Acid; (-)-Repaglinide; AG-EE 624ZW; Repaglinide EP Impurity E; R-Repaglinide; (R)-(-)-Repaglinide. Grades: > 95%. CAS No. 147852-26-4. Molecular formula: C27H36N2O4. Mole weight: 452.6. | |
| Retagliptin | Retagliptin is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It may be used to treat type 2 diabetes. Synonyms: SP-2086; UNII-328C4R3P9L. Grades: 98%. CAS No. 1174122-54-3. Molecular formula: C19H18F6N4O3. Mole weight: 464.4. | |
| RET Inhibitor 2667 | RET Inhibitor 2667 is a potent RET inhibitor (IC50 value <10 nM) with activity against wild-type RET and its mutants. Synonyms: 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. Grades: 99%. CAS No. 1980023-80-0. Molecular formula: C26H25FN10O. Mole weight: 512.54. | |
| Retinyl glucoside | Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals. Synonyms: Retinyl β-D-glucoside. Grades: >98%. CAS No. 136778-12-6. Molecular formula: C26H40O6. Mole weight: 448.59. | |
| RET Kinase Inhibitor 1 | RET Kinase Inhibitor 1 is a gut-restricted inhibitor of RET kinase. It is under development for the treatment of irritable bowel syndrome. Synonyms: GSK3179106; 2-[4-(4-ethoxy-6-oxo-1H-pyridin-3-yl)-2-fluorophenyl]-N-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]acetamide. CAS No. 1627856-64-7. Molecular formula: C22H21F4N3O4. Mole weight: 467.4. | |
| Retosiban | Retosiban is a oxytocin receptor antagonist. It was developed by GlaxoSmithKline for the treatment of preterm labour. Retosiban has high affinity for the oxytocin receptor with Ki value of 0.65 nM. It has greater than 1400-fold selectivity over the related vasopressin receptors. Uses: Preterm labour. Synonyms: GSK221149A; GSK 221149A; GSK-221149A; GSK221149; GSK 221149; GSK-221149; GSK221,149; GSK 221,149; GSK-221,149; Retosiban; (3R,6R)-6-((2S)-Butan-2-yl)-3-(2,3-dihydro-1H-inden-2-yl)-1-((1R)-1-(2-methyl- 1,3-oxazol-4-yl)-2-(morpholin-4-yl)-2-oxoethyl)piperazine-2,5-dione. Grades: 98%. CAS No. 820957-38-8. Molecular formula: C27H34N4O5. Mole weight: 494.59. | |
| RETRA hydrochloride | RETRA hydrochloride, an antitumor agent, inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Synonyms: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride. Grades: ≥99% by HPLC. CAS No. 1173023-52-3. Molecular formula: C11N11NO3S2.HCl. Mole weight: 305.8. | |
| Retro-2 | Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network. It has been shown to be effective against a range of bacterial and virus pathogens, both in vitro and in animal models. Synonyms: RN 1-001; 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone. Grades: ≥98%. CAS No. 1429192-00-6. Molecular formula: C19H16N2OS. Mole weight: 320.4. | |
| Reversan | Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (Mdr-1) and P-glycoprotein (P-gp), which may be clinically useful for the treatment of neuroblastoma. Synonyms: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 313397-13-6. Molecular formula: C26H27N5O2. Mole weight: 441.52. | |
| Reversin 121 | Reversin 121 is a selective P-glycoprotein multidrug transporter (MDR1) inhibitor with Kd value of 77 nM. Synonyms: reversin 121; 174630-04-7; CHEMBL221390; tert-butyl (2S) -2-[[ (2S) -2-[ (2-methylpropan-2-yl) oxycarbonylamino]-4-oxo-4-phenylmethoxybutanoyl]amino]-6- (phenylmethoxycarbonylamino) hexanoate; Boc-Asp(Obzl)-Lys(Z)-OtBu; BDBM50326927; DB14072; HY-125486; Reversin 121, >=97% (HPLC), powder; CS-0091919; (S)-tert-butyl 2-((S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanamido)-6-(benzyloxycarbonylamino)hexanoate; tert-Butyl N2-((S)-4-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoyl)-N6-((benzyloxy)carbonyl)-L-lysinate. Grades: ≥98%. CAS No. 174630-04-7. Molecular formula: C34H47N3O9. Mole weight: 641.8. | |
| (R)-Ezetimibe | Azetidinone Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3'R)-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grades: > 95%. CAS No. 163380-16-3. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| RFRP-1 (human) | RFRP-1 (human), a mammalian ortholog of avian gonadotropin inhibitory hormone (GnIH), is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). RFRP-1 exhibits anorexigenic, anti-fertility, and anxiogenic activities. RFRP-1-secreting neurons are stress activated and inhibit the secretion of gonadotropin and gonadotropin-releasing hormone (GnRH). In vivo, this peptide inhibits reproductive behavior, decreases food intake, and increases anxiety behavior in an oxytocin-mediated manner. Synonyms: MPHSFANLPLRF; MPHSFANLPLRF-NH2. CAS No. 311309-25-8. Molecular formula: C67H101N19O14S. Mole weight: 1428.72. | |
| RFRP 3 (human) | RFRP-3 (RFamide-related peptide-3), a homolog of avian gonadotropin-inhibitory hormone, is an agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). The human RFRP-3 was recently shown to potently inhibit GnRH stimulation of gonadotropin secretion from sheep in vivo and from cultured gonadotropes through inhibition of Ca2+ mobilization. Synonyms: NPVF; Neuropeptide VF (124-131) (human); H-Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2; L-valyl-L-prolyl-L-asparagyl-L-leucyl-L-prolyl-L-glutaminyl-L-arginyl-L-phenylalaninamide; Neuropeptide NPVF; RFamide-related peptide 3; L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH2. Grades: ≥95% by HPLC. CAS No. 311309-27-0. Molecular formula: C45H72N14O10. Mole weight: 969.15. | |
| RG 102240 | RG 102240 is a stimulant, which induces a potent activator of gene expression. It does not cause significant changes in endogenous gene expression in HEK cells. Synonyms: 2-Ethyl-3-methoxybenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide; GS-E; GS-E (ligand); RSL 1; RheoSwitch Ligand 1; RheoSwitch Ligand RSL 1; RG-102240; RG 102240; RG102240. Grades: ≥98% by HPLC. CAS No. 162326-49-0. Molecular formula: C23H30N2O3. Mole weight: 382.5. | |
| RG108 | RG108 is a DNA methyltransferase inhibitor with IC50 value of 115 nM. RG108 can enhance reprogramming of somatic cells to induced pluripotent stem (iPS) cells. Synonyms: N-Phthalyl-L-tryptophan; RG-108; (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid. Grades: >98%. CAS No. 48208-26-0. Molecular formula: C19H14N2O4. Mole weight: 334.33. | |
| RG3039 | RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the SMN1 gene. It improves motor function in SMA mice. It also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. It was developed by Repligen and now in Clinic Phase 1 with no progress. Uses: Rg3039 is used for the treatment for spinal muscular atrophy(sma). Synonyms: RG3039; RG 3039; RG-3039; PF06687859; PF 06687859; PF-06687859. 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine;5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine. Grades: >98 %. CAS No. 1005504-62-0. Molecular formula: C21H23Cl2N5O. Mole weight: 432.35. | |
| RG7-0099 | RG7-0099 is a small-molecule and dual inhibitor of IDO1/TDO (IDO1 IC50 < 100nM while TDO IC50 < 100nM) , which modulate immunosuppressive effects. In preclinical models, it significantly reduced Kyn levels. RG7-0099 is potentially used in various cancers. Uses: Potential antitumor drug. Synonyms: RG7-0099; RG7 0099; RG70099. | |
| (R)-GNE-140 | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor (IC50s= 3 nM for LDHA and 5 nM for LDHB), with 18-fold more potent than S enantiomer. Synonyms: (2R)-5-(2-chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one; GNE-140; GNE 140; GNE140. CAS No. 2003234-63-5. Molecular formula: C25H23ClN2O3S2. Mole weight: 499.04. | |
| RHC 80267 | RHC 80267 is a selective inhibitor of DAGL (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively) that demonstrates relatively weak inhibition of phospholipases A2 and C. It potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM). Uses: Protease inhibitors. Synonyms: RHC80267; RHC 80267; RHC-80267; U 57908; U57908. O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone. Grades: ≥95% by HPLC. CAS No. 83654-05-1. Molecular formula: C20H34N4O4. Mole weight: 394.51. | |
| Rhodamine-123 | Rhodamine-123 is a cell-permeant green-fluorescent probe that is taken up by active mitochondria. Synonyms: Rh 123. CAS No. 62669-70-9. Molecular formula: C21H17ClN2O3. Mole weight: 380.82. | |
| Rhodamine B amine | Rhodamine B amine is a high sensitive fluorescence derivatization reagent for mono- and oligosaccharides. Synonyms: 9-(4-Amino-2-carboxyphenyl)-6-(diethylamino)-N,N-diethyl-3H-xanthen-3-iminium chloride. Grades: 90% by TLC (total isomers). CAS No. 100992-88-9. Molecular formula: C28H31N3O3. Mole weight: 457.56. | |
| Rhodamine B hydrazide | Rhodamine B hydrazide is a water-soluble fluorescent probe used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin. Synonyms: 2-amino-3',6'-bis(diethylamino)-spiro[1H-isoindole-1,9'-[9H]xanthen]-3(2H)-one. Grades: ≥98%. CAS No. 74317-53-6. Molecular formula: C28H32N4O2. Mole weight: 456.6. | |
| Rhodiocyanoside A | Rhodiocyanoside A is a cyanogenic glucoside found in the Rhodiola quadrifida with inhibitory activity against histamine. Synonyms: (2Z)-4-(beta-D-glucopyranosyloxy)-2-methylbut-2-enenitrile; (2Z)-2-methyl-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}but-2-enenitrile. Grades: >98%. CAS No. 168433-86-1. Molecular formula: C11H17NO6. Mole weight: 259.258. | |
| RHPS 4 methosulfate | RHPS 4 is a Telomerase inhibitor and G-quadruplex ligand. RHPS 4 inhibits growth of medulloblastoma and glioblastoma cells in vitro, and it induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Synonyms: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate; RHPS 4 methosulfate; RHPS-4; RHPS 4; RHPS4. Grades: ≥98% by HPLC. CAS No. 390362-78-4. Molecular formula: C22H17F2N2.CH3O4S. Mole weight: 458.48. | |
| RI-1 | RI-1 is a selective inhibitor of RAD51, which is a central gene molecule of homologous recombination, with IC50 ranging from 5 to 30 μM. Synonyms: RI-1; RI1; RI 1. RAD51 inhibitor 1. Grades: >98%. CAS No. 415713-60-9. Molecular formula: C14H11Cl3N2O3. Mole weight: 361.61. | |
| RI-2 | RI-2, a fully reversible RAD51 inhibitor (IC50 = 44.2 μM) that had been treated with RI-2 prior to washing exhibited no measurable loss of DNA binding activity. In vitro: It has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linki. Synonyms: 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-morpholin-4-ylpyrrole-2,5-dioneRI-2; RI 2; RI2CHEMBL23167261417162-36-7C21H18Cl2N2O4SCHEMBL15758872AOB3500 BDBM50424495AKOS026750570HY-16904; HY 16904; HY16904B58811-(3,4-Dichlorophenyl)-3-morpholino-4-(4-methoxyphenyl)-1H-pyrrole. CAS No. 1417162-36-7. Molecular formula: C21H18Cl2N2O4. Mole weight: 433.28. | |
| Ribociclib | Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. Synonyms: LEE011; LEE 011; LEE-011; Kisqali. CAS No. 1211441-98-3. Molecular formula: C23H30N8O. Mole weight: 434.55. | |
| Riboflavin | Riboflavin, also known as vitamin B2, is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: Riboflavine; Lactoflavin; (-)-Riboflavin; 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol; 7,8-Dimethyl-10-ribitylisoalloxazine; Beflavin; Beflavine; Flavaxin; Lactobene; Lactoflavine; NSC 33298; Ribipca; Ribocrisina; Riboderm; Ribosyn; Ribotone; Ribovel; Ricrolin; Vitaflavine; Vitamin B2; Vitamin G; Vitasan B2. Grades: >98%. CAS No. 83-88-5. Molecular formula: C17H20N4O6. Mole weight: 376.36. | |
| Ridinilazole | Ridinilazole is a non-absorbable small molecule antibiotic for oral administration to treat Clostridium difficile infection (CDI), showed statistical superiority in sustained clinical response ('SCR') rates compared to the standard of care, vancomycin. Uses: Antibiotic for oral administration to treat clostridium difficile infection. Synonyms: SMT-19969; SMT 19969; SMT19969; Ridinilazole2,2'-di(pyridin-4-yl)-1H,1'H-5,5'-bi(benzimidazole). Grades: ≥98%. CAS No. 308362-25-6. Molecular formula: C24H16N6. Mole weight: 388.42. | |
| Ridogrel | Ridogrel is a thromboxane synthase inhibitor used for the prevention of systemic thrombo-embolism. It is also a receptor antagonist that may be used as an adjunctive agent to thrombolytic therapy in acute myocardial infarction. It was developed by Xian Janssen and was terminated in clinic phase 3 trials. Uses: Ridogrel is used for the prevention of systemic thrombo-embolism. it also may be used as an adjunctive agent to thrombolytic therapy in acute myocardial infarction. Synonyms: Ridogrel, R 68070; R-68070; R68070; R 70416; R-70416; R70416; 5-[[Pyridin-3-yl-[3- (trifluoromethyl) phenyl]methylidene]amino]oxypenta noic acid; 5-[[ (E) - (3-Pyridinyl) [3- (trifluoromethyl) phenyl]methylene]aminooxy]valeric acid; 5-[[[ (E) -α - (Pyridine-3-yl) -3- (trifluoromethyl) benzylidene]amino]oxy]valeric acid;R-68070;Pentanoic acid, 5-[[ (E) -[3-pyridinyl[3- (trifluoromethyl) phenyl]methylene]amino]oxy]-. Grades: 95%. CAS No. 110140-89-1. Molecular formula: C18H17F3N2O3. Mole weight: 366.33. | |
| Rilapladib | Rilapladib is the third genomics-derived small molecule drug as a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor which is an enzyme associated with the formation of atherosclerotic plaques. Uses: 1-alkyl-2-acetylglycerophosphocholine esterase inhibitors. Synonyms: GSK 659032; GSK659032; GSK-659032; SB-659032; SB659032; SB 659032; GTPL7376; GTPL-7376; GTPL 7376; D05728. Grades: ≥98%. CAS No. 412950-08-4. Molecular formula: C40H38F5N3O3S. Mole weight: 735.81. | |
| Riletamotide | Riletamotide is a telomerase reverse transcriptase (human TERT, hTERT, EC: 2.7.7.49) (651-665)-peptide, an immunoreagent for active immunity. Synonyms: L-Alanyl-L-α-glutamyl-L-arginyl-L-leucyl-L-threonyl-L-seryl-L-arginyl-L-valyl-L-lysyl-L-alanyl-L-leucyl-L-phenylalanyl-L-seryl-L-valyl-L-leucine. CAS No. 524061-04-9. Molecular formula: C76H132N22O21. Mole weight: 1690.00. | |
| Rimexolone | Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye for the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis. Uses: Anti-inflammatory. Synonyms: Trimexolone; Org 6216; Org6216; Org-6216; 11β-Hydroxy-16α,17α,21-trimethylpregna-1,4-dien-3,20-dione. Grades: ≥98%. CAS No. 49697-38-3. Molecular formula: C24H34O3. Mole weight: 370.52. | |
| Riociguat | Riociguat (BAY 63-2521; BAY 632521) is a novel drug that is currently in clinical development by Bayer. At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators. Synonyms: BAY 63-2521; BAY63-2521; BAY632521; Riociguat; Brand name: Adempas. Grades: 0.99. CAS No. 625115-55-1. Molecular formula: C20H19FN8O2. Mole weight: 422.424. | |
| RIPA-56 | RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) (IC50 = 13 nM), and efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multiorgan damage. Synonyms: RIPA-56; RIPA-56; RIPA-56. N-benzyl-N-hydroxy-2,2-dimethylbutanamide. CAS No. 1956370-21-0. Molecular formula: C13H19NO2. Mole weight: 221.3. | |
| Risedronate Sodium | Risedronate Sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. Uses: Bone density conservation agents. Synonyms: NE 58095 Sodium; NE58095 Sodium; NE-58095 Sodium. Grades: >98%. CAS No. 115436-72-1. Molecular formula: C7H10NNaO7P2. Mole weight: 305.09. | |
| RI-STAD 2 | RI-STAD 2 is a cell-permeable AKAP disruptor that interacts with recombinant human RI subunits. Molecular formula: C109H181N25O35. Mole weight: 2401.75. | |
| Ritobegron ethyl hydrochloride | Ritobegron is a potential Bladder selectivity of the novel β3-agonist. Uses: Beta 3 adrenergic receptor agonists. Synonyms: KUC 7483; KUC7483; KUC-7483;ethyl 2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)-2,5-dimethylphenoxy)acetate hydrochloride. Grades: ≥98%. CAS No. 476333-91-2. Molecular formula: C23H32ClNO5. Mole weight: 437.96. | |
| Rivaroxaban Amine Impurity | Rivaroxaban Amine Impurity is an impurity of Rivaroxaban, a factor Xa (FXa) inhibitor used for the prevention and treatment of thromboembolic disorders. Synonyms: 2-[2-[N-(5-Chlorothiophene-2-carbonyl)-4-[(5S)-5-[[(5-chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]anilino]ethoxy]acetic acid. CAS No. 1151893-81-0. Molecular formula: C24H21Cl2N3O7S2. Mole weight: 598.48. | |
| Rivaroxaban Impurity A hydrochloride | Rivaroxaban Impurity A hydrochloride is an impurity of Rivaroxaban, a factor Xa (FXa) inhibitor used for the prevention and treatment of thromboembolic disorders. Synonyms: 2- [2- [ [4- [ (5S) ?-5- [ [ [ (5-Chloro-2-thienyl) ?carbonyl] ?amino] ?methyl] ?-2-oxo-3-oxazolidinyl] ?phenyl] ?amino] ?ethoxy] ?-acetic Acid Hydrochloride. CAS No. 931117-61-2. Molecular formula: C19H21Cl2N3O6S. Mole weight: 490.36. | |
| Rivaroxaban Pseudodimer | Rivaroxaban Pseudodimer is an impurity of Rivaroxaban, a factor Xa (FXa) inhibitor used for the prevention and treatment of thromboembolic disorders. Synonyms: 5-chloro-N- [ [ (5S) -3- [4- [ (5-chlorothiophene-2-carbonyl) - [2- [2-oxo-2- [ [ (5S) -2-oxo-3- [4- (3-oxomorpholin-4-yl) phenyl] -1, 3-oxazolidin-5-yl] methylamino] ethoxy] ethyl] amino] phenyl] -2-oxo-1, 3-oxazolidin-5-yl] methyl] thiophene-2-carboxamide. CAS No. 1632463-24-1. Molecular formula: C38H36Cl2N6O10S2. Mole weight: 871.8. | |
| Rivastigmine | Rivastigmine, a carbamate derivative, is a reversible cholinesterase inhibitor that is selective for the central nervous system to treat Alzheimer's Disease. Uses: Neuroprotective agents. Synonyms: [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate; (S)-N-ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate; 713, ENA; 713, SDZ ENA; ENA 713; ENA 713, SDZ; ENA-713; ENA713; Exelon; Hydrogen Tartrate, Rivastigmine; rivastigmine; Rivastigmine Hydrogen Tartrate; RivastigmineTartrate; SDZ ENA 713; Tartrate, Rivastigmine Hydrogen; 123441-03-2; ENA 713 free base; (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate; 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate; 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate; AB1004572; 3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate; Exelonreg; Nimvastid; 3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate; (S)-3-[1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate; [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methyl-carbamate; [3-[(1S)-1-dimethylaminoethyl]phenyl] N-ethyl-N-methylcarbamate; 3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate; 3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl N-methyl carbamate; Ethyl-methyl-carbamic acid 3-(1-dimethylamino-ethyl)-phenyl. CAS No. 123441-03-2. Molecular formula: C14H22N2O2. Mole weight: 250.34. | |
| RK-33 | RK-33 is a first-in-class inhibitor of DDX3. It causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells, which has therapeutic use in cancers. Synonyms: RK 33; RK33. CAS No. 1070773-09-9. Molecular formula: C23H20N6O3. Mole weight: 428.44. | |
| RKI-1447 | RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition. Synonyms: RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. Grades: >98%. CAS No. 1342278-01-6. Molecular formula: C16H14N4O2S. Mole weight: 326.374. | |
| (R)-KT109 | (R)-KT109 is the R isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109. Synonyms: (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2R)-2-(phenylmethyl)-1-piperidinyl]-methanone. Grades: ≥98%. CAS No. 2055172-60-4. Molecular formula: C27H26N4O. Mole weight: 422.52. | |
| (R)-(+)-Lansoprazole | Dexlansoprazole is a proton pump inhibitor that is marketed by Takeda Pharmaceuticals for the treatment of erosive esophagitis and gastro-oesophageal reflux disease. Uses: Anti-ulcer agents. Synonyms: T 168390; TAK 390; T168390; TAK390; T-168390; TAK-390; Dexlansoprazole; Dexilant; Kapidex; TAK-390MR; TAK 390MR; TAK390MR. Grades: >98%. CAS No. 138530-94-6. Molecular formula: C16H14F3N3O2S. Mole weight: 369.36. | |
| (R)-Linezolid | (R)-Linezolid is an enatiomeric impurity of Linezolid, an antibiotic used for the treatment of infections caused by Gram-positive bacteria. Synonyms: N-{[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl}acetamide; Linezolid R-Isomer; N-[[(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide; Acetamide, N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-; Linezolid R-isomer [USP-RS]; Linezolid Impurity R-isomer. Grades: ≥95%. CAS No. 872992-20-6. Molecular formula: C16H20FN3O4. Mole weight: 337.35. | |
| (R)-Lisofylline | LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (R)-LSF is the biologically active isomer of LSF. Uses: Adjuvants, immunologic. Synonyms: (-)-Lisofylline; (R)-LSF; 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione. Grades: ≥97%. CAS No. 100324-81-0. Molecular formula: C13H20N4O3. Mole weight: 280.3. | |
| (R)-Methyl 3-aminobutanoate hydrochloride | Synonyms: (R)-3-Amino-butyric acid methyl ester, HCl; Methyl (R)-homo-beta-alaninate HCl; Butanoic acid, 3-amino-, methyl ester, hydrochloride (1:1), (3R)-. Grades: 95%. CAS No. 139243-54-2. Molecular formula: C5H12ClNO2. Mole weight: 153.61. | |
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