BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| PF 4693627 | PF 4693627 is a potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) that has the potential to treat inflammation (IC50 value 3 nM and 109 nM in enzyme assay and WHB assay respectively). Uses: Potential treatment of inflammation. Synonyms: PF-4693627; PF 4693627; PF4693627. 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide. Grades: 99%. CAS No. 1312815-93-2. Molecular formula: C26H29Cl2N3O3. Mole weight: 502.43. |  |
| PF 4800567 | PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM). Synonyms: PF 4800567; PF4800567; PF-4800567; 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine. Grades: 98%. CAS No. 1188296-52-7. Molecular formula: C17H18ClN5O2. Mole weight: 359.81. | |
| PF-5190457 | PF-5190457 is a selective Growth hormone secretagogue receptor inverse agonist and it can increase insulin secretion in glucose-stimulated human islets. No recent reports of development were reported for phase-I development in Type-2-diabetes-mellitus. Uses: Type 2 diabetes mellitus. Synonyms: PF-5190457; PF 5190457; PF5190457; PF-05190457; PF05190457; PF 05190457; (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one. Grades: 95%. CAS No. 1334782-79-4. Molecular formula: C29H32N6OS. Mole weight: 512.67. | |
| PF-543 | PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(I) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. Uses: Enzyme inhibitors. Synonyms: PF-543; PF543; PF 543. Grades: 0.98. CAS No. 1415562-82-1. Molecular formula: C27H31NO4S. Mole weight: 465.60. | |
| PF-543 Citrate | Cell-permeant reversible inhibitor of SphK1 (IC50 value 2.0 nM; Ki value 3.6 nM). PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Synonyms: PF543 Citrate; PF 543 Citrate. Grades: >98%. CAS No. 1415562-83-2. Molecular formula: C33H39NO11S. Mole weight: 657.73. | |
| PF-543 hydrochloride | The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological studies. IC50: 2 nM; Ki: 3.6 nM. Synonyms: PF-543 hydrochloride; PF 543 hydrochloride; PF543 hydrochloride; (2R) -1-[[4-[[3-Methyl-5-[ (phenylsulfonyl) methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol Hydrochloride. Grades: 98%. CAS No. 1706522-79-3. Molecular formula: C27H31NO4S.HCl. Mole weight: 502.07. | |
| PF-6260933 | PF-6260933 is a potent and selective inhibitor of MAP4K4. Synonyms: 5-(6-Aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine. CAS No. 1811510-56-1. Molecular formula: C16H13ClN4. Mole weight: 296.75. | |
| PF-670462 | PF-670462 is a potent and selective inhibitor of CK1ε in isolated enzyme preparations. It inhibits PER protein nuclear translocation causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. It less effectively inhibits a wide variety of related or common kinases. It disrupts circadian rhythms in cells and animals and blocks the locomotor response to amphetamines in mice. It remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. Synonyms: PF-670462; PF 670462; PF670462;PF-670462 HCl; PF-670462 hydrochloride. Grades: >98%. CAS No. 950912-80-8. Molecular formula: C19H22Cl2FN5. Mole weight: 410.32. | |
| PF9 tetrasodium salt | PF9 tetrasodium salt is an activator of GPR17 (EC50 = 36 pM). Synonyms: PF9 tetrasodium salt; PF 9 tetrasodium salt; PF-9 tetrasodium salt; 2-(Phenylethynyl)adenosine-5'-triphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 851265-78-6. Molecular formula: C18H16N5Na4O13P3. Mole weight: 695.23. | |
| PFK-158 | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Synonyms: PFK158; PFK 158; PFK158; ACTPFK158. Grades: >98%. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. | |
| PGP-4008 | PGP-4008 is a selective P-glycoprotein (P-gp) inhibitor without modulating multidrug resistance-related protein 1 (MRP1). In combination with doxorubicin, PGP-4008 inhibited tumor growth in a murine syngeneic Pgp-mediated MDR solid tumor model. Synonyms: N-(1-Benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide. Grades: ≥95%. CAS No. 365565-02-2. Molecular formula: C26H23N3O. Mole weight: 393.5. | |
| PH-002 | PH-002 is an inhibitor of apolipoprotein E4 (ApoE4) intramolecular domain interaction in neuronal cells. It prevents impairments of mitochondrial motility and neurite outgrowth. Synonyms: Tert-butyl 4- [ [4- [ [2- (3-methyl-4-oxophthalazin-1-yl) acetyl] amino] phenyl] methyl] piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1311174-68-1. Molecular formula: C27H33N5O4. Mole weight: 491.58. | |
| Phellodendrine chloride | Phellodendrine chloride can be found in the peel of Phellodendron amurense Rupr. Phellodendrine was effective in crescentic-type anti-GBM nephritis and the antinephritic mechanisms of this agent may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Uses: Hypoglycemic/anti-virus. Synonyms: 6H-Dibenzo[a,g]quinolizinium,5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride (1:1), (7S,13aS)-. Grades: >98%. CAS No. 104112-82-5. Molecular formula: C20H24NO4.Cl. Mole weight: 377.85. | |
| Phenamil | Phenamil, a second generation analog of amiloride (hydrochloride), inhibits TRPP3-mediated currents (IC50 = 0.14 μM) and also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Synonyms: 2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-; 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]-2-pyrazinecarboxamide; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(phenylamidino)-; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-; Phenylamil; 3,5-diamino-6-chloro-N-(N-phenylcarbamimidoyl)pyrazine-2-carboxamide; 3, 5-Diamino-6-chloro-N-[imino (phenylamino) methyl]pyrazinecarboxamide. Grades: ≥95%. CAS No. 2038-35-9. Molecular formula: C12H12ClN7O. Mole weight: 305.72. | |
| Phenazopyridine Hydrochloride | Phenazopyridine Hydrochloride is a local analgesic that has been used in urinary tract disorders. Grades: >98%. CAS No. 136-40-3. Molecular formula: C11H11N5.HCl. Mole weight: 249.7. | |
| Phenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside | Phenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside: an essential biochemical reagent involved in the synthesis of glycosides and glycosidase inhibitors with potential anti-cancer properties.Leveraging it as a substrate for enzyme assays makes it a valuable addition to research experiments. Caution must be exercised as it is not intended for human consumption and requires careful handling. The multifacted nature of this product showcases a complex interplay of chemical functionalities, which in turn further reinforce its importance as a key biochemical reagent. CAS No. 3427-45-0. Molecular formula: C20H24O10. Mole weight: 424.4. | |
| Phenyl 2-hydroxy-4,5-dimethoxybenzoate | Phenyl 2-hydroxy-4,5-dimethoxybenzoate is an impurity of Acotiamide, a drug for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. Synonyms: 2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester; Benzoic acid, 2-hydroxy-4,5-dimethoxy-, phenyl ester; Acotiamide Impurity 35. Grades: ≥98%. CAS No. 877997-98-3. Molecular formula: C15H14O5. Mole weight: 274.27. | |
| Phenyl 3,4,6-Tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxyformamido)-b-D-glucopyranoside | Phenyl 3,4,6-Tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxyformamido)-b-D-glucopyranoside, an intricate chemical entity, is extensively employed in the realm of biomedical research. Its utilization spans diverse applications embracing the examination of pharmaceutical interplays and the formulation of remedies for numerous ailments. The compound possesses distinctive characteristics and exhibits intricate phenomena, thereby enabling comprehensive inquiries into drug metabolism, protein binding, and receptor interactions. Synonyms: (2R, 3S, 4R, 5R, 6S) -2- (Acetoxymethyl) -6- (phenylthio) -5- ( ( (2, 2, 2-trichloroethoxy) carbonyl) amino) tetrahydro-2H-pyran-3, 4-diyl diacetate; Phenyl 3,4,6-Tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxyformamido)-beta-D-glucopyranoside; Phenyl 3, 4, 6-Tri-O-acetyl-2-deoxy-1-thio-2- (2, 2, 2-trichloroethoxycarbonylamino) -?-D-glucopyranoside; (2R, 3S, 4R, 5R, 6S) -2- (Acetoxymethyl) -6- (phenylthio) -5- ( ( (2, 2, 2-trichloroethoxy) carbonyl) amino) tetrahydro-2H-pyran-3, 4-diyldiacetate; Phenyl 2-deoxy-1-thio-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]--D-glucopyranoside 3,4,6-triacetate; Phenyl 3,4,6-Tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-beta-D-glucopyranoside; Phenyl 3,4,6-Tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-ss-D-glucopyranoside. CAS No. 187022-49-7. Molecular formula: C21H24Cl3NO9S. Mole weight: 572.84. | |
| Phenyl 4-O-acetyl-2,6-Di-O-benzoyl-1-thio-beta-thio-beta-D-galactopyranoside | Phenyl 4-O-acetyl-2,6-Di-O-benzoyl-1-thio-beta-thio-beta-D-galactopyranoside is a compound, exhibiting its paramount significance in delving deep into the enigmatic realms of glycosylation processes and the enthralling world of carbohydrate chemistry. It effortlessly assumes the dual roles of an eminent substrate in an immense array of biochemical assays, particularly those centered around the captivating realms of glycosyltransferases, glycosidases and various other riveting carbohydrate enzymes. Synonyms: β-D-Galactopyranoside, phenyl 1-thio-, 4-acetate 2,6-dibenzoate. CAS No. 152488-28-3. Molecular formula: C28H26O8S. Mole weight: 522.57. | |
| Phenyl methylcarbamate | Phenyl methylcarbamate can be used as a biomarker of colorectal cancer. It also used as an insecticide. Synonyms: Methylcarbamic acid phenyl ester; NSC 128138; Phenmec; N-Methylphenylcarbamate; Phenyl monomethylcarbamate; Carbamic acid, methyl-, phenyl ester; Phenol, methylcarbamate; Carbamic acid, N-methyl-, phenyl ester. Grades: ≥95%. CAS No. 1943-79-9. Molecular formula: C8H9NO2. Mole weight: 151.16. | |
| PHGDH-inactive | PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503. It can be used as a negative control for NCT-502 and NCT-503. Synonyms: 3-Phosphoglycerate Dehydrogenase-inactive; N-(4,6-dimethylpyridin-2-yl)-4-pyridin-4-ylpiperazine-1-carbothioamide. Grades: ≥98%. CAS No. 1914971-16-6. Molecular formula: C17H21N5S. Mole weight: 327.5. | |
| PhiKan 083 | PhiKan 083 is a critical p53 stabilizing agent by bonding its mutation Y220C. Synonyms: PhiKan 083; PhiKan083; PhiKan-083; 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 880813-36-5. Molecular formula: C16H18N2.HCl. Mole weight: 274.79. | |
| Phosphatidyl-L-serine; DSPS | Cas No. 51446-62-9. | |
| Phosphodiesterase 4 Inhibitor | An phosphodiesterase 4 (PDE4) inhibitor with IC50 values of 33 and 21 nm for PDE4B and PDE4D, respectively. Synonyms: PDE4 Inhibitor; 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester; Ethyl 3,5-dimethyl-1-(3-nitrophenyl)pyrazole-4-carboxylate. Grades: ≥98%. CAS No. 346440-86-6. Molecular formula: C14H15N3O4. Mole weight: 289.3. | |
| Phospho(enol)pyruvic acid tri(cyclohexylammonium) salt | The chemical compound, Phospho(enol)pyruvic acid tri(cyclohexylammonium) salt, is a complex and multifaceted substance extensively utilized in the biomedical field for investigating ailments related to glycolysis, such as cancer and diabetes. Additionally, this compound acts as a pivotal substrate for enzymes, enabling the detection and diagnosis of these conditions. Synonyms: Phosphoenolpyruvic Acid tris(Cyclohexylammonium) Salt; 2-(Phosphonooxy)-2-propenoic acid tri(cyclohexylammonium) salt; PEP-3CHA. Grades: ≥98%. CAS No. 35556-70-8. Molecular formula: C3H5O6P.3C6H13N. Mole weight: 465.56. | |
| Phosphonic acid, [(1S)-1-hydroxyethyl]-, dimethyl ester | Dimethyl ester of [(1S)-1-hydroxyethyl]-phosphonic acid is an intriguing derivative of phosphonic acid that has been analyzed extensively due to its potential as an anti-osteoporotic drug as well as its application as a chelating agent for heavy metal ions and a flame retardant for polymers. Its multifaceted usage makes it an attractive compound for further research and development. Synonyms: [(S)-1-Hydroxyethyl]phosphonic acid dimethyl ester; Phosphonic acid, P-[(1S)-1-hydroxyethyl]-, dimethyl ester; Dimethyl [(1S)-1-hydroxyethyl]phosphonate; dimethyl (S)-(1-hydroxyethyl)phosphonate. Grades: 95%. CAS No. 106692-44-8. Molecular formula: C4H11O4P. Mole weight: 154.10. | |
| Phosphonic acid, (2-ethylhexyl)-, mono(2-ethylhexyl) ester | (2-Ethylhexyl) diphenyl phosphate, an esteemed biomedical commodity, boasts of its versatility in the medical industry as a plasticizing agent employed in medical apparatuses, notably PVC tubing and blood bags, while also exhibiting efficacy in ameliorating a myriad of neurological illnesses, particularly Alzheimer's disease, thanks to its calcium modulating properties within the brain. Synonyms: 2-Ethylhexyl hydrogen-2-ethylhexylphosphonate; (2-Ethylhexyl)phosphonic Acid Mono-2-ethylhexyl Ester. Grades: Solid Content: 98±2 %. CAS No. 14802-03-0. Molecular formula: C16H35O3P. Mole weight: 306.42. | |
| Phosphoramidochlorid?ic acid, N,?N-?dimethyl-?, [ (2S, ?6R) ?-?6-?[6-? (benzoylamino) ?-?9H-?purin-?9-?yl]?-?4-? (triphenylmethyl) ?-?2-?morpholinyl]?methyl ester | Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester is a novel biomedical compound. With its unique molecular structure, it exhibits potential as a targeted therapeutic agent for treating various diseases. Synonyms: PMO-BzA. CAS No. 956139-18-7. Molecular formula: C38H37ClN7O4P. Mole weight: 722.17. | |
| Phosphoric acid 6,6'-di(9-anthryl)-1,1'-spirobiindan-7,7'-diyl ester | Phosphoric acid 6,6'-di(9-anthryl)-1,1'-spirobiindan-7,7'-diyl ester is a chiral phosphoric acid catalyst for a variety of enantioselective transformations, especially for carbon-carbon and carbon-heteroatom bond-forming reactions. Synonyms: 3,7-Di(9-anthryl)-10,11,12,13-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-ol 5-oxide. Grades: 98%. CAS No. 1393527-23-5. Molecular formula: C45H31O4P. Mole weight: 666.70. | |
| Photoswitchable PAD Inhibitor | Photoswitchable PAD inhibitor is a photoactivated inhibitor of protein arginine deiminase (PAD), which plays a role in the pathogenesis of various diseases, including rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis, and breast cancer. Synonyms: Photoswitchable PAD inhibitor; 2226393-62-8; N-[(1S)-4-[(1-amino-2-chloroethylidene)amino]-1-(1H-benzimidazol-2-yl)butyl]-4-phenyldiazenylbenzamide; N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-(2-phenyldiazenyl)-benzamide; AKOS040754853; PD121672; Photoswitchable PAD Inhibitor (technical grade). CAS No. 2226393-62-8. Molecular formula: C26H26ClN7O. Mole weight: 487.98. | |
| PHPS1 | PHPS1 is a cell-permeable inhibitor of the protein tyrosine phosphatase Shp2, a positive modulator of growth factor signaling. It is selective for Shp2 over ECPTP, PTP1B, Shp1, and mycobacterium MptpA. Synonyms: Phenylhydrazonopyrazolone sulfonate 1; Protein Tyrosine Phosphatase Inhibitor V; PTP Inhibitor V; [4-[[5-[4-(nitromethyl)phenyl]-3-oxo-2-phenyl-1H-pyrazol-4-yl]diazenyl]phenyl]methanesulfonic acid. Grades: ≥98%. CAS No. 314291-83-3. Molecular formula: C21H15N5O6S. Mole weight: 465.4. | |
| PHPS1 sodium salt | PHPS1 is a cell-permeable inhibitor of the protein tyrosine phosphatase Shp2, a positive modulator of growth factor signaling. It is selective for Shp2 over ECPTP, PTP1B, Shp1, and mycobacterium MptpA. Synonyms: 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt. Grades: ≥98% by HPLC. Molecular formula: C21H14N5O6SNa. Mole weight: 487.42. | |
| Phthalocyanine Cobalt(II) | Cobalt phthalocyanine, a novel molecular recognition reagent, is a catalyst of redox reaction. Uses: A catalyst of redox reaction. Synonyms: Cobalt(II) Phthalocyanine. Grades: ≥95.0%. CAS No. 3317-67-7. Molecular formula: C32H16CoN8. Mole weight: 571.46. | |
| Physcion-1-O-β-D-glucoside | Physcion-1-O-β-D-glucoside is a diterpenoid compound. Synonyms: Physcion 8-glucoside; 1-Hydroxy-3-methoxy-6-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)anthracene-9,10-dione. Grades: >98%. CAS No. 26296-54-8. Molecular formula: C22H22O10. Mole weight: 446.408. | |
| PI4KIIIbeta-IN-10 | PI4KIIIbeta-IN-10, a potent anti-viral agent, is a highly PI4KIIIβ inhibitor with weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3K&beta. Synonyms: N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide PI4KIIIbeta-IN-10 SCHEMBL14851574. CAS No. 1881233-39-1. Molecular formula: C22H25N3O5S2. Mole weight: 475.58. | |
| PI4KIIIbeta-IN-9 | PI4KIIIbeta-IN-9, a thiazole derivative, is a selective PI4KIIIβ inhibitor over PI3Kγ (>140-fold) and PI3Kδ (>20-fold). Studies shows that this compounds may be formulated or provided to a subject in combination with a second anti-infective agent. IC50: P. Synonyms: N- [5- [3- [ (4-hydroxyphenyl) sulfamoyl] -4-methoxyphenyl] -4-methyl-1, 3-thiazol-2-yl] cyclopentanecarboxamidePI4KIIIbeta-IN-9SCHEMBL14851744CS-5620; HY-19798; CS 5620; HY 19798; CS5620; HY19798; 5S8. CAS No. 1429624-84-9. Molecular formula: C23H25N3O5S2. Mole weight: 487.59. | |
| PI4KIII β inhibitor 3 | The most effective test compound, the compound of formula 3 (PI4KIII beta inhibitor 3), inhibited IL2 and IFNy secretion with IC50 values of less than 1 nM in each case. Thus, the compound of formula (3) was shown to be as effective at inhibiting IL2 and IFNy secretion as conventional immunosuppressants such as cyclosporine A. IC50 on IFNy and IL-2 release of Cyclosporine A are 2nM and less than 1 nM respectively. Twelve animals received daily treatment with vehicle (1%methylcellulose), twelve others received PI4KIII beta inhibitor 3 at 40 mg/kg/d in 1% methylcellulose. Synonyms: PI4KIII beta inhibitor 3. Grades: >98%. CAS No. 1245319-54-3. Molecular formula: C22H22N8OS. Mole weight: 446.53. | |
| Picfeltarraenin IB | Picfeltarraenin IB is a triterpenoid Picria isolated from felterrae Lour. Synonyms: HY-N2211. Grades: 98%. CAS No. 97230-46-1. Molecular formula: C42H64O14. Mole weight: 792.95. | |
| Picfeltarraenin X | Picfeltarraenin X is a triterpenoid compound isolated from the herbs of Picria felterrae Lour. Picfeltarraenin X exhibits inhibitory effect against AChE. Synonyms: (2beta,3alpha,9beta,10alpha,16alpha)-2-(beta-D-Glucopyranosyloxy)-20,24-epoxy-3,16-dihydroxy-9-methyl-19-norlanosta-5,23-diene-11,22-dione. Grades: >98%. CAS No. 1391826-61-1. Molecular formula: C36H54O11. Mole weight: 662.817. | |
| Picloxydine | Picloxydine, a heterocyclic biguanide, has antibacterial and antiplaque properties. In vitro studies have shown that the antibacterial properties of chlorhexidine and picloxydine are similar. Synonyms: 1-N', 4-N'-bis[N'- (4-chlorophenyl) carbamimidoyl]piperazine-1, 4-dicarboximidamide; 1, 1- (p-chlorophenylguanidinoformimidonyl) bis piperazine picloxidine; picloxydine; picloxydine dihydrochloride; Vitabact. CAS No. 5636-92-0. Molecular formula: C20H24Cl2N10. Mole weight: 475.38. | |
| Picoplatin | Picoplatin is a new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis. Synonyms: AMD473; AMD 473; AMD-473; NX 473; NX473; NX-473; ZD0473; ZD 0473; ZD-0473. CAS No. 181630-15-9. Molecular formula: C6H10Cl2N2Pt. Mole weight: 376.15. | |
| Picotamide | Picotamide is a dual inhibitor of thromboxane A2 (TXA2) receptors and TXA2 synthase. It is used as an antiplatelet drug. Picotamide has been demonstrated that reduces overall mortality in type 2 diabetic patients with associated peripheral arterial disease (PAD). Synonyms: 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide. Grades: ≥98%. CAS No. 32828-81-2. Molecular formula: C21H20N4O3. Mole weight: 376.4. | |
| Picrocrocin | Picrocrocin is a monoterpene glycoside found in the saffron. Synonyms: Saffron-bitter; Picrocrocine; (4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexene-1-carbaldehyde. CAS No. 138-55-6. Molecular formula: C16H26O7. Mole weight: 330.377. | |
| Picroside III | Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS) that protects liver. Uses: Protecting liver. Synonyms: [(1aS)-1a, 1bα, 2, 5aα, 6, 6aβ-Hexahydro-6α-[(E)-3-(4-hydroxy-3-methoxyphenyl)propenoyloxy]-1aβ-(hydroxymethyl)oxireno[4, 5]cyclopenta[1, 2-c]pyran-2α-yl]β-D-glucopyranoside; Picroside III; (1aS, 1bS, 2S, 5aR, 6S, 6aS)-1a, 1b, 2, 5a, 6, 6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4, 5]cyclopenta[1, 2-c]pyran-2-yl beta-D-glucopyranoside 6-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate]; [(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-[(E)-3-(4-hydroxy-3-Methoxyphenyl)propenoyloxy]-1aβ-(hydroxyMethyl)oxireno[4,5]cy; AMphicoside ?. Grades: >98%. CAS No. 64461-95-6. Molecular formula: C25H30O13. Mole weight: 538.5. | |
| Picroside IV | Picroside IV is a compound of the iridoids found in the roots of Picrorhiza scrophulariiflora. Synonyms: β-D-Glucopyranoside, (1aS, 1bS, 2S, 5aR, 6S, 6aS)-1a, 1b, 2, 5a, 6, 6a-hexahydro-. Grades: >98%. CAS No. 211567-04-3. Molecular formula: C24H28O12. Mole weight: 508.5. | |
| Pidotimod Impurity X | An impurity of Pidotimod which increases the concentration of salivary IgA directed against bacteria. Synonyms: 3-(5,8-Dioxohexahydro-1H-thiazolo[3,4-a]pyrazin-6-yl)propanoic acid; Pidotimod Diketopiperazine-6-propanoic Acid; 3-(5,8-dioxohexahydro-3H-thiazolo[3,4-a]pyrazin-6-yl)propanoic acid; 3H-Thiazolo[3,4-a]pyrazine-6-propanoic acid, hexahydro-5,8-dioxo-; 3-(5,8-dioxo-3,6,7,8a-tetrahydro-1H-[1,3]thiazolo[3,4-a]pyrazin-6-yl)propanoic acid; FT-0673899; F78336; 3-{5,8-dioxo-hexahydro-1H-[1,3]thiazolo[3,4-a]pyrazin-6-yl}propanoic acid. Grades: > 95%. CAS No. 161771-75-1. Molecular formula: C9H12N2O4S. Mole weight: 244.27. | |
| Pidotimod Impurity Y | An impurity of Pidotimod which is an immunomodulator. Synonyms: Pidotimod Impurity Y; 161771-76-2; 1H,3H,5H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine5,8,10(5aH,10aH)-trione,dihydro-; Dihydro-1H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(3H,5aH,10aH)-trione; 5-thia-1,7-diazatricyclo[7.3.0.03,7]dodecane-2,8,12-trione; tetrahydro-3H,5H,10H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(5aH)-trione; Pidotimod Diketopiperazine; DTXSID801137585; BCP33578; Dihydro-1H,3H,5H-pyrrolo[1,2-a]thiazolo[3,4-d]pyrazine-5,8,10(5aH,10aH)-trione; F78340; J-009858; 5-thia-1,7-diazatricyclo[7.3.0.0,dodecane-2,8,12-trione; 5-THIA-1,7-DIAZATRICYCLO[7.3.0.0(3),?]DODECANE-2,8,12-TRIONE; Pidotimod Diketopiperazine; 5-Thia-1,7-diazatricyclo[7.3.0.03,7]dodecane-2,8,12-trione. Grades: > 95%. CAS No. 161771-76-2. Molecular formula: C9H10N2O3S. Mole weight: 226.26. | |
| Pifithrin-α hydrobromide | Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Synonyms: Pifithrin-alpha; Pifithrin alpha; PFT-alpha; PFTalpha; PFT alpha. Grades: >98%. CAS No. 63208-82-2. Molecular formula: C16H18N2OS·HBr. Mole weight: 367.3. | |
| PIM-1 Inhibitor 2 | PIM-1 Inhibitor 2, a pyrimidinyl-benzisoxazolo compound, is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region. Synonyms: 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine; PIMi II. Grades: ≥98% by HPLC. CAS No. 477845-12-8. Molecular formula: C17H11ClN4O. Mole weight: 322.75. | |
| PIM447 | This active molecular is a potent PIM 1, 2, and 3 kinase inhibitor under the development of Novartis. In vivo, PIM447 reduces the tumor burden and also preventes tumor-associated bone loss in a disseminated murine model of human myeloma. In vitro, it inhibits osteoclast formation and resorption. Moreover, it increases osteoblast activity and mineralization. In May 2016, Novartis completed a phase I trial for Multiple myeloma (Second-line treatment or greater) in Japan. Uses: Multiple myeloma. Synonyms: PIM447; PIM 447; PIM-447; LGH-447;N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide. Grades: 98%. CAS No. 1210608-43-7. Molecular formula: C24H23F3N4O. Mole weight: 440.47. | |
| PIM inhibitor 1 phosphate | PAK4-IN-1 is an inhibitor of Pim (IC50 < 35 nM). Synonyms: 2-Pyridinecarboxamide, N-[(7R)?-4-[(3R,?4R,?5S)?-3-amino-4-hydroxy-5-methyl-1-piperidinyl]?-6,?7-dihydro-7-hydroxy-5H-cyclopenta[b]?pyridin-3-yl]?-6-(2,?6-difluorophenyl)?-5-fluoro-, phosphate (1:1). CAS No. 2088852-47-3. Molecular formula: C26H29F3N5O7P. Mole weight: 611.51. | |
| Pinane Thromboxane A2 | Pinane Thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TXA2R antagonist and a TXA synthase inhibitor. It inhibits coronary artery constriction and platelet aggregation. Synonyms: 15(S)-Pinane Thromboxane A2; Pinane TXA2; PTA2; 7-[3-(3-hydroxyoct-1-enyl)-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 71111-01-8. Molecular formula: C24H40O3. Mole weight: 376.6. | |
| Pinol | Pinol is a natural product found in Agathosma betulina. Synonyms: 6-Oxabicyclo[3.2.1]oct-3-ene, 4,7,7-trimethyl-; p-Menth-1-ene, 8-epoxy-; NSC-407159. Grades: ≥95%. CAS No. 2437-97-0. Molecular formula: C10H16O. Mole weight: 152.23. | |
| Pioglitazone Imino Impurity | An impurity of Pioglitazone which a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: 5-{4-[2-(5-Ethyl-2-pyridinyl) ethoxy] benzyl}-2-imino-4-thiazolidinedione; EPEBI. Grades: > 95%. CAS No. 105355-26-8. Molecular formula: C19H21N3O2S. Mole weight: 355.46. | |
| Pioglitazone Impurity A | Cas No. 625853-74-9. | |
| Pipazetate | Pipazetate, as a cough suppressant, is a non-narcotic oral antitussive agent acting centrally on the medullary cough center. Synonyms: 2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate; Pipazethate; Pipazetate; Theratuss; Lenopect; Pipazetatum[INN-Latin]; 2167-85-3. Grades: 95%. CAS No. 2167-85-3. Molecular formula: C21H25N3O3S. Mole weight: 399.506. | |
| Piperacetazine | Piperacetazine is an antipsychotic drug, most notably used for schizophrenia. Uses: An antipsychotic drug. Synonyms: 1-[10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]phenothiazin-2-yl]ethanone. Grades: ≥98%. CAS No. 3819-00-9. Molecular formula: C24H30N2O2S. Mole weight: 410.579. | |
| Piperazine-1,4-diethylamine | Piperazine-1,4-diethylamine (CAS# 6531-38-0 ) is a useful research chemical. Synonyms: 1,4-Piperazinediethanamine; 2,2'-(piperazine-1,4-diyl)diethanamine. Grades: 98 %. CAS No. 6531-38-0. Molecular formula: C8H20N4. Mole weight: 172.27. | |
| Piperazine citrate (1:1) | Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an anthelmintic. Synonyms: Antepar. CAS No. 14396-16-8. Molecular formula: C6H8O7.C4H10N2. Mole weight: 282.248. | |
| Piperazine citrate (3:2) | Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an anthelmintic. It can be used for ascariasis of livestock and poultry, as well as horse pinworm disease, trichinosis, and esophageal nematode disease of cattle, sheep and pigs. Synonyms: Antepar. Grades: >98%. CAS No. 144-29-6. Molecular formula: C24H48N6O15. Mole weight: 660.67. | |
| Piperidolate | Piperidolate is a tertiary amine antimuscarinic. It is similar to atropine. It is mainly used in the smooth muscle spasm of the gastrointestinal tract and inhibits intestinal cramp induced by acetylcholine in rats and dogs. Uses: Piperidolate is mainly used in the smooth muscle spasm of the gastrointestinal tract and inhibits intestinal cramp induced by acetylcholine in rats and dogs. Synonyms: 1-Ethyl-3-piperidinyl diphenylacetate;3-Piperidinol, 1-ethyl-, diphenylacetate;Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester;Alpha-phenyl-benzeneaceticaci1-ethyl-3-piperidinylester;AN 1087;Benzeneacetic acid, alpha-phenyl-, 1-ethyl-3-piperidinyl ester;Dactil;1-Ethylpiperidin-3-yl 2,2-diphenylacetate;N-Ethyl-3-piperidyl diphenylacetate. Grades: >98%. CAS No. 82-98-4. Molecular formula: C21H25NO2. Mole weight: 323.43. | |
| Pipobroman | Pipobroman (trade names Vercite, Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. It is marketed by Abbott Laboratories. Pipobroman (PB) has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Uses: Antineoplastic agents, alkylating. Synonyms: NSC25154; NSC 25154; NSC-25154; 3-bromo-1-[4-(3-bromopropanoyl) piperazin-1-yl]-propan-1-one. Grades: >98%. CAS No. 54-91-1. Molecular formula: C10H16Br2N2O2. Mole weight: 356.05. | |
| PIR 3.5 | PIR 3.5 is a negative control of IPA 3, an allosteric inhibitor of group I PAK activation. Synonyms: 2-Naphthalenol, 6,6'-dithiobis-; 2-Naphthol, 6,6'-dithiodi-; 6,6'-Dithiobis[2-naphthalenol]; (6,6'-Dihydroxy-2,2'-dinaphthyl)disulfide; 2,2'-Dihydroxy-6,6'-dinaphthyl disulfide; 6,6'-Dithiodi(2-naphthol); Bis(6-hydroxy-2-naphthyl)disulfide; DDD (analytical); NSC 87629. Grades: ≥98% by HPLC. CAS No. 6088-51-3. Molecular formula: C20H14O2S2. Mole weight: 350.45. | |
| Pirenzepine hydrochloride | Pirenzepine hydrochloride is an antiulcerative that acts via suppressing gastric secretion. Pirenzepine is a selective muscarinic M1 receptor antagonist. Uses: M1 muscarinic receptor selective antagonist. Synonyms: Pirenzepine dihydrochloride; Pirenzepine HCl; Bisvanil; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5-H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride. Grades: >98%. CAS No. 29868-97-1. Molecular formula: C19H23Cl2N5O2. Mole weight: 424.33. | |
| Piroxicam-β-cyclodextrin | Piroxicam-β-cyclodextrin is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic properties. Synonyms: Piroxicam-beta-cyclodextrin; Chf 1194; Chf-1194; Piroxicam mixture with beta-cyclodextrin. CAS No. 96684-39-8. Molecular formula: C57H83N3O39S. Mole weight: 1466.33. | |
| Pirozadil | Pirozadil is a drug used to treat type IIa hyperlipidemia. Synonyms: Pemix. Grades: 98%. CAS No. 54110-25-7. Molecular formula: C27H29NO10. Mole weight: 527.5. | |
| PIT 1 | PIT 1 is an apoptosis inducing selective PIP3 antagonist which has been shown to inhibit the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). PIT 1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling, and exhibits antitumor activity in vivo. Synonyms: Pit-1; Pit 1; Pit1. N-[[ (3-Chloro-2-hydroxy-5-nitrophenyl) amino]thioxomethyl]benzamide. Grades: ≥99% by HPLC. CAS No. 53501-41-0. Molecular formula: C14H10ClN3O4S. Mole weight: 351.76. | |
| Pitavastatin 5-Oxo Impurity Calcium Salt | An impurity in the synthesis of Pitavastatin, a HMG-CoA reductase inhibitor that lowers LDL cholesterol and triglycerides and increase HDL cholesterol in your blood. Synonyms: (3R,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3-hydroxy-5-oxo-6-heptenoic acid calcium salt (2:1). CAS No. 2180095-22-9. Molecular formula: C50H42CaF2N2O8. Mole weight: 876.9. | |
| Pitavastatin Impurity 8 | An impurity of Pitavastatin which lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Synonyms: 3,5-Dideoxy-2,4-O-(1-methylethylidene)-D-erythro-hexuronic Acid 1,1-Dimethylethyl Ester. Grades: > 95%. CAS No. 1044518-75-3. Molecular formula: C13H22O5. Mole weight: 258.32. | |
| Pitavastatin Lactone | A metabolite of Pitavastatin which is a member of the blood cholesterol lowering medication class of statins. Uses: Hydroxymethylglutaryl-coa reductase inhibitors. Synonyms: Itavastatin Lactone; (4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one. Grades: > 95%. CAS No. 141750-63-2. Molecular formula: C25H22FNO3. Mole weight: 403.46. | |
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