BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| PBIT | PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B. Synonyms: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one. Grades: ≥98% by HPLC. CAS No. 2514-30-9. Molecular formula: C14H11NOS. Mole weight: 241.31. |  |
| (-)-p-Bromotetramisole Oxalate | (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. Synonyms: (-)-p-Bromotetramisole oxalate; L-p-BROMOTETRAMISOLE OXALATE; S(-)-p-Bromotetramisole oxalate; (S)-(-)-4-Bromotetramisole oxalate; L-(-)-p-Bromotetramisole oxalate; (-)-p-Bromolevamisole oxalate; (-)-4-Bromotetramisole oxalate; (-)-p-Bromotetramisole (oxalate); (S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate; 6-Bromolevamisole oxalate; R 30402 oxalate; EU-0100021; ()-p-Bromolevamisole oxalate; BMK1-H3; MLS000860040; CHEMBL1256792; Bromotetramisole, L-(-) oxalate; HMS2231M14; HMS3260E03; BCP16717; Tox21_500021; s7383; (-)-p-Bromolevamisole oxalate, 99%; AKOS030526170; CCG-221325; CS-5385; LP00021; NCGC00093544-01; NCGC00260706-01; AS-72721; HY-19695; SMR000326898; MLS-0317970.P017; SW220284-1; C75926; SR-01000075599; SR-01000075599-1; (6S)-6-(4-BROMOPHENYL)-2H,3H,5H,6H-IMIDAZO[2,1-B][1,3]THIAZOLE; OXALIC ACID; (S)-(-)-4-Bromotetramisole Oxalate; (-)-4-bromotetramisole oxalate salt; ()-p-Bromolevamisole oxalate. Grades: >98%. CAS No. 62284-79-1. Molecular formula: C13H13BrN2O4S. Mole weight: 373.22. | |
| PBTZ169 | PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The MIC values of PBTZ169 ranged from 0.03 μg/mL to 0.0037 μg/mL. The MIC50 value of PBTZ169 was 0.0075μg/mL; MIC90 value was 0.030 μg/mL. Uses: Anti-bacterial. Synonyms: PBTZ169; PBTZ-169; PBTZ 169; macozinone; 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one. Grades: 98%. CAS No. 1377239-83-2. Molecular formula: C20H23F3N4O3S. Mole weight: 456.48. | |
| PCNA I1 | PCNA-I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. It inhibits growth of a range of tumor cell lines in vitro. It induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells. Synonyms: PCNA I1; PCNA-I1; PCNAI1; N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide. Grades: ≥98% by HPLC. CAS No. 444930-42-1. Molecular formula: C17H14N2O2S. Mole weight: 310.37. | |
| PCO371 | PCO371 is a selective PTHR1 agonist that can be used to treat hypoparathyroidism. Synonyms: PCO-371; PCO 371. Grades: >98%. CAS No. 1613373-33-3. Molecular formula: C29H32F3N5O6S. Mole weight: 635.7. | |
| PD 0220245 | PD 0220245 is a non-peptide interleukine 8 (IL-8) receptor antagonist. Synonyms: PD 0220245; PD0220245; PD-0220245; N-[6,7-dichloro-3-(5-thiophen-2-ylthiophen-2-yl)quinoxalin-2-yl]-N',N'-diethylbutane-1,4-diamine dihydrochloride. Grades: 99%. CAS No. 640736-79-4. Molecular formula: C24H26Cl2N4S2.2HCl. Mole weight: 578.45. | |
| PD0325901 | PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. Uses: Reprogramming, self-renewal. Synonyms: PD 0325901; PD 325901. Grades: >98%. CAS No. 391210-10-9. Molecular formula: C16H14F3IN2O4. Mole weight: 482.198. | |
| PD 099560 | PD 099560, a benzopyran derivative, has been found to be a HIV-1 protease inhibitor that could be significant in HIV studies. Synonyms: PD-099560; PD099560; PD 099560; 4-Hydroxy-3-(3-phenoxypropyl)-2H-1-benzopyran-2-one; PD-099560; PD099560; 3PhOPr-4OHBzpyran2one. Grades: 98%. CAS No. 155758-74-0. Molecular formula: C18H16O4. Mole weight: 296.32. | |
| PD 125754 | This active molecular is a Renin inhibitor that applicated in treatment of essential hypertension. Uses: Essential hypertension. Synonyms: PD125754; PD-125754; PD 125754; tert-butyl ((2S,3S)-6-(((2S,3S)-5-(((S)-1-((3-(aminomethyl)benzyl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl)amino)-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate. Grades: 98%. CAS No. 124339-32-8. Molecular formula: C42H65N5O7. Mole weight: 752.00. | |
| PD 125967 | PD 125967 is a renin inhibitor which may be useful for treatment of essential hypertension. Uses: Essential hypertension. Synonyms: PD125967; PD-125967; PD 125967; 5-(3-(1H-imidazol-4-yl)-2-(3-(naphthalen-1-yl)-2-(naphthalen-1-ylmethyl)propanamido)propanamido)-6-cyclohexyl-4-hydroxy-2-isobutyl-N-(2-methylbutyl)hexanamide. Grades: 98%. CAS No. 128139-14-0. Molecular formula: C51H67N5O4. Mole weight: 814.12. | |
| PD 130883 | This active molecular is a potent lipophilic quinazoline antifolate and data show that marked PD130883 suppression of thymidylate synthase slows the rate but not the extent of tetrahydrofolate cofactor interconversion to dihydrofolate upon complete suppression of dihydrofolate reductase with trimetrexate. Synonyms: CHEMBL62769;123685-36-9;2-Amino-6-(((4-nitrophenyl)-2-propynylamino)methyl)-4(3H)quinazolinone;4(3H)-Quinazolinone,2-amino-6-[[(4-nitrophenyl)-2-propyn-1-ylamino]methyl]-;ACMC-20mqpf;PD-130883; PD130883; PD 130883. Grades: 95%. CAS No. 123685-36-9. Molecular formula: C18H15N5O3. Mole weight: 349.34. | |
| PD 130908 | PD 130908 is an effective hypoxic cytotoxin as an analogue of RSU 1069, but less potent than the hypoxic cell radiosensitizer RSU 1069. Toxicity toward hypoxic tumor cells in vivo is demonstrated by clamping tumors (for 60 min) following administration of PD 130908. No development was reported for the treatment of cancer. Uses: Cancer. Synonyms: PD-130908; PD130908; PD 130908; N-(2-bromoethyl)-3-(2-nitro-1H-imidazol-1-yl)propan-1-amine hydrobromide. Grades: 98%. CAS No. 131505-02-7. Molecular formula: C8H14Br2N4O2. Mole weight: 358.03. | |
| PD 131628 | PD 131628 is a new fluoroquinolone as the bioactive form of PD 131112 which is a antibacterial agent originated by Pfizer. PD 131112 can be used for the treatment of infections with penicillin-resistant and -susceptible pneumococci, but no development has been published yet. Uses: Bacterial infections. Synonyms: PD-131628; PD131628; PD 131628; (S)-7-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. Grades: 98%. CAS No. 127967-03-7. Molecular formula: C16H17FN4O3. Mole weight: 332.33. | |
| PD 132002 | PD 132002 is a renin inhibitor originated by Pfizer. In Dec 2001, clinical trials for Hypertension in USA was discontinued. Uses: Hypertension. Synonyms: PD-132002; PD132002; PD 132002; (2R)-methyl 3-amino-2-((2S)-N-((2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-3-oxopropanoate. Grades: 98%. CAS No. 134452-04-3. Molecular formula: C31H50N4O9S. Mole weight: 654.81. | |
| PD 136450 | PD-136,450 is a Cholecystokinin type B receptor antagonist originated by Pfizer. It is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. It has therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. No development for the treatment of Peptic ulcer was reported. Uses: Peptic ulcer. Synonyms: Cam 1189; Cam-1189; Cam1189; PD-136450; PD136450; PD 136450;(E)-4-((2-(2-(((adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-1-phenylethyl)amino)-4-oxobut-2-enoic acid. Grades: 98%. CAS No. 139067-52-0. Molecular formula: C35H40N4O6. Mole weight: 612.72. | |
| PD 138142 | PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development for Hypercholesterolaemia in USA was discontinued. Uses: Hypercholesterolaemia. Synonyms: PD-138142; PD138142; PD 138142; 2,6-diisopropylphenyl (2,6-diisopropylphenoxy)carbonylsulfamate. Grades: 98%. CAS No. 142642-31-7. Molecular formula: C25H35NO5S. Mole weight: 461.62. | |
| PD-138312 | PD-138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a difluorophenyl substitution or a cyclopropyl at the 1 positions, respectively. It has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens in vitro activity. It was evaluated for its in vivo potencies against acute systemic infections and pneumococcal in mice pneumonia model. Uses: Pd-138312 has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens. Synonyms: PD-138312; PD138312; PD 138312;7-(3-(2-Aminopropan-2-yl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;7-(3-(1-Amino-1-methylethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: >98%. CAS No. 107334-06-5. Molecular formula: C19H23FN4O3. Mole weight: 374.41. | |
| PD 142505-0028 | PD 142505-0028, also know as CI-1017, has been found to be a muscarinic agonist that could exhibit effect against cognition disorder so that was once studied in AD. Synonyms: CI-1017; CI1017; CI 1017; PD-142505-0028; PD42505-0028; PD 142505-0028; CTK4D0956; 1-Azabicyclo[2.2.1]heptan-3-one,O-[3-(3-methoxyphenyl)-2-propyn-1-yl]oxime. Grades: 98%. CAS No. 161774-09-0. Molecular formula: C18H20N2O6. Mole weight: 360.36. | |
| PD 145305 | PD 145305 is an inactive analog of PD 150606, a selective calpain inhibitor. Synonyms: 3-phenyl-2-sulfanylpropanoic acid; Benzylthioglykolsaure. Grades: ≥95%. CAS No. 90536-15-5. Molecular formula: C9H10O2S. Mole weight: 182.2. | |
| PD 168368 | PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors. It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide. Grades: ≥95%. CAS No. 204066-82-0. Molecular formula: C31H34N6O4. Mole weight: 554.6. | |
| PD173074 | PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. Uses: Differentiation, self-renewal. Synonyms: PD173074; PD 173074; PD-173074. Grades: 0.98. CAS No. 219580-11-7. Molecular formula: C28H41N7O3. Mole weight: 523.682. | |
| PD-1/PD-L1 Inhibitor 1 | PD-1/PD-L1 Inhibitor 1, is an inhibitor of the PD-1 /PD-Ll protein/protein interaction. Synonyms: PD1-PDL1 inhibitor 1; PD1-PDL1-IN1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; (2S) -1-[[2, 6-dimethoxy-4-[ (2-methyl-3-phenylphenyl) methoxy]phenyl]methyl]piperidine-2-carboxylic acidPD1-PDL1 inhibitor 1CHEMBL3582252(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid1675201-83-8. CAS No. 1675201-83-8. Molecular formula: C29H33NO5. Mole weight: 475.58. | |
| PD-1/PD-L1 inhibitor 2 | The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM. Synonyms: BMS-202; BMS 202; BMS202. Grades: 98%. CAS No. 1675203-84-5. Molecular formula: C25H29N3O3. Mole weight: 419.52. | |
| PD 404182 | PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM), and also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). PD 404182 is a potential antibiotic of gram negative bacteria. Synonyms: PD-404182; PD 404182; PD404182. 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Grades: ≥98% by HPLC. CAS No. 72596-74-8. Molecular formula: C11H11N3S. Mole weight: 217.29. | |
| PD 90780 | PD 90780, a pyrazoloquinazolinone compound, is a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells), which binds NGF, not p75NTR. Differential activity of PD90780 suggests altered NGF-p75NTR interactions in the presence of TrkA. It may be useful in identifying the region(s) of nerve growth factor involved in binding to the p75 receptor and in clarifying the role of p75 receptor in the actions of the neurotrophins. Synonyms: PD 90780; PD90780; PD-90780; 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 77422-99-2. Molecular formula: C19H14N4O4. Mole weight: 362.34. | |
| PD98059 | PD98059 is a potent, selective and cell-permeant inhibitor of MAP kinase kinase. It enhances human embryonic stem cell self-renewal. Synonyms: PD-98059; 2-(2-amino-3-methoxyphenyl)chromen-4-one. Grades: >98%. CAS No. 167869-21-8. Molecular formula: C16H13NO3. Mole weight: 267.284. | |
| PDD 00017273 | PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM), with >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. PARG has been shown to be involved in the repair of single strand DNA breaks. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair. Synonyms: 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide. Grades: ≥98% by HPLC. CAS No. 1945950-21-9. Molecular formula: C23H26N6O4S2. Mole weight: 514.62. | |
| PDK1 inhibitor | PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent. Grades: >98%. CAS No. 1001409-50-2. Molecular formula: C28H22F2N4O4. Mole weight: 516.5. | |
| PDK1 inhibitor 2610 | PDK1 inhibitor 2610 is an ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB, respectively). Synonyms: PDK1 inhibitor 2610; 2108463-93-8; 853909-77-0; PDK1inhibitor2610; 2-(4-(8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile hydrochloride. Grades: 99%. CAS No. 2108463-93-8. Molecular formula: C25H15N5.HCl. Mole weight: 421.88. | |
| PDM-11 | PDM-11 is a derivative of resveratrol. Compared with resveratrol, PDM-11 has a stronger affinity for aromatic hydrocarbon receptor (AhR) and does not have any affinity for estrogen receptors. Synonyms: PDM11; 1-[2-(4-Chloro-Phenyl)-Vinyl]-3,5-DiMethoxy-Benzene; CHEMBL1172974; PDM 11. Grades: 98%. CAS No. 1032508-03-4. Molecular formula: C16H15ClO2. Mole weight: 274.74. | |
| Peficitinib | Peficitinib is a potent JAK inhibitor with IC50 values of 3.9, 5.0, 0.71 and 4.8 nM for JAK1, JAK2, JAK3 and TYK2 enzyme activities, respectively. It inhibits the IL-2-induced proliferation of human T cells with IC50 value of 18 nM. Moreover, peficitinib is 14-fold more potent against JAK1/3 than JAK2/2 on the basis of EPO-induced proliferation of human leukemia cells. Peficitinib has been used for the treatment of psoriasis and rheumatoid arthritis. Uses: Inhibited jak1, jak2, jak3 and tyk2 enzyme activities with ic50 values of 3.9, 5.0, 0.71 and 4.8 nm, respectively; inhibited the il-2-induced proliferation of human t cells with an ic50 value of 18 nm. Synonyms: ASP015K; ASP-015K; 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide. Grades: >98%. CAS No. 944118-01-8. Molecular formula: C18H22N4O2. Mole weight: 326.39. | |
| PEG-MGF | PEG-MGF is a polyethylene glycol structure attached to a larger mechano growth factor molecule. It is a derived form of the IGF-1 (insulin-like growth factor-1), which stimulates myoblasts division and allows for muscle fibers to fuse and mature. Synonyms: Pegylated MGF, PEG IGF-1 Ec. Grades: >95%. Molecular formula: C121H200N42O39. Mole weight: 2948.15. | |
| Pegsitacianine | Pegsitacianine is a diagnostic imaging agent. Polymer. Synonyms: α-bromo-ω-{2-methyl-1-[α-methylpoly(oxyethylene)-ω-oxy]-1-oxopropan-2-yl}poly{[2-(dibutylamino)ethyl methacrylate]-co-(2-acetamidoethyl methacrylate)-co-(2-{6-[(2E)-2-{(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene}-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl]hexanamido}ethyl methacrylate) (0.97:0.02:0.01)}; 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-3-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,1-dimethyl-, inner salt, reaction products with acetic anhydride, 2-aminoethyl methacrylate hydrochloride-2-(dibutylamino)ethyl methacrylate polymer and polyethylene glycol 2-bromo-2-methylpropanoate Me ether. CAS No. 2396651-85-5. Molecular formula: [ (C14H27NO2)x (C8H13NO3)y (C51H59N3O6S)z]m. (C2H4O)n. C5H9BrO2. | |
| Peimisine | Peimisine is an alkaloid FR 5 from Fritillaria thunbergii, and an angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant herb in traditional Chinese medicine. Uses: Antitussive; anti-ulcer. Synonyms: Ebeiensine. Grades: >98%. CAS No. 19773-24-1. Molecular formula: C27H41NO3. Mole weight: 427.62. | |
| Pemetrexed Disodium | Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Synonyms: LY231514 disodium; Alimta; Rolazar; Tifolar; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2); L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt; LY-231514 disodium; LY 231514 disodium; Pemetrexed sodium; sodium (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate. Grades: >98%. CAS No. 150399-23-8. Molecular formula: C20H19N5Na2O6. Mole weight: 471.37. | |
| Pemigatinib | Pemigatinib is an inhibitor of fibroblast growth factor receptor types 1, 2, and 3 (FGFR1/2/3). Under the brand name Pemazyre, it is used as a medication for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma. Synonyms: INCB054828. CAS No. 1513857-77-6. Molecular formula: C24H27F2N5O4. Mole weight: 487.5. | |
| PEN (human) | PEN (human), a proSAAS-derived neuropeptide, is an endogenous peptide GPR83 agonist. Synonyms: AADHDVGSELPPEGVLGALLRV. CAS No. 597578-70-6. Molecular formula: C97H159N27O32. Mole weight: 2215.49. | |
| Penicillamine | Penicillamine is used as an antirheumatic and as a chelating agent in Wilson's disease. Synonyms: Dimethyl Cysteine. Grades: >98%. CAS No. 52-67-5. Molecular formula: C5H11NO2S. Mole weight: 149.21. | |
| PEN (mouse) | PEN, an abundant peptide in the brain that has been implicated in the regulation of feeding, is an endogenous peptide GPR83 agonist. PEN (mouse) activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus. CAS No. 1236955-25-1. Molecular formula: C102H169N27O34. Mole weight: 2317.62. | |
| PEN (rat) | PEN (rat), a proSAAS-derived neuropeptide, is an endogenous peptide GPR83 agonist. PEN is an abundant peptide in the brain that has been implicated in the regulation of feeding. Synonyms: AVDQDLGPEVPPENVLGALLRV. CAS No. 569364-13-2. Molecular formula: C102H169N27O33. Mole weight: 2301.62. | |
| Pentamethylcyclopentadienylbis (triphenylphosphine)ruthenium (II) chloride | Pentamethylcyclopentadienylbis (triphenylphosphine)ruthenium (II) chloride (CAS# 92361-49-4 ) is a useful research chemical. Synonyms: Chloro (pentamethylcyclopentadienyl)bis (triphenylphosphine)ruthenium (II), Cp*RuCl(PPh3)2. CAS No. 92361-49-4. Molecular formula: [(C10H15)Ru(P((C6H5)3))2Cl]. Mole weight: 796.32. | |
| Pentane, 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)- | Synonyms: 3-Methoxyperfluoro(2-methylpentane); 1,1,1,2,3,4,4,5,5,5-Decafluoro-3-methoxy-2-(trifluoromethyl)pentane. Grades: 95%. CAS No. 132182-92-4. Molecular formula: C7H3F13O. Mole weight: 350.08. | |
| Pentylamine-6-carboxyltetramethylrhodamine TFA salt | Pentylamine-6-carboxyltetramethylrhodamine TFA salt, also called Xanthylium, 9-[5-[[(5-aminopentyl)?amino]?carbonyl]?-2-carboxyphenyl]?-3,?6-bis(dimethylamino)?-, inner salt, is a novel molecular rhodamine-type fluorescent probe. Uses: A novel molecular rhodamine-type fluorescent probe. Synonyms: Xanthylium, 9-[5-[[(5-aminopentyl)?amino]?carbonyl]?-2-carboxyphenyl]?-3,?6-bis(dimethylamino)?-, inner salt. Grades: ≥ 97.0%. CAS No. 709025-58-1. Molecular formula: C30H34N4O4. Mole weight: 514.62. | |
| Pentyl phenoxyacetate | Synonyms: Phenoxyacetic acid pentyl ester. CAS No. 74525-52-3. Molecular formula: C13H18O3. Mole weight: 222.28. | |
| Pepstatin A | Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). Uses: Protease inhibitors. Synonyms: Pepstatin; NSC 272671; NSC-272671; NSC272671; Pepstatin A; Pepstatina; Pepstatinum; Pepstatin A. Grades: >98%. CAS No. 26305-03-3. Molecular formula: C34H63N5O9. Mole weight: 685.89. | |
| Peptide5 | Peptide5 is a mimetic peptide of Connexin 43 (Cx43), which is the most ubiquitously expressed type of Cx in the skin. It reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Synonyms: VDCFLSRPTEKT; Peptide5; Peptide 5; Peptide-5. CAS No. 916977-43-0. Molecular formula: C60H98N16O20S. Mole weight: 1395.59. | |
| Perfluoro(4-methylpent-2-ene) | Perfluoro(4-methylpent-2-ene) is an exceptional compound with diverse applications, particularly in the fabrication of various fluorinated polymers and resins like the ubiquitous Teflon. Furthermore, this specialty chemical is indispensable in the pharmaceutical and electronics industries. It holds immense potential in the synthesis of surfactants as well. Nonetheless, there is limited knowledge on its therapeutic benefits against drugs or pathologies. Synonyms: perfluoro(4-methyl-2-pentene). Grades: 95%. CAS No. 2070-70-4. Molecular formula: C6F12. Mole weight: 300.05. | |
| Perindopril Erbumine | Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykinin/angiotensin I selectivity ratio of 1.44. Uses: Angiotensin-converting enzyme inhibitors. Synonyms: S9490-3. Grades: >98%. CAS No. 107133-36-8. Molecular formula: C19H32N2O5.C4H11N. Mole weight: 441.6. | |
| Perindopril Related Compound 1 HCl | An impurity of Perindopril which is a potent vasoconstrictor in the renin-angiotensin-aldosterone system (RAAS). Synonyms: (2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylic acid hydrochloride; (2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride; 1H-Indole-2-carboxylic acid, octahydro-, hydrochloride (1:1), (2S,3aR,7aS)-; (2S,3aR,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylic acid; hydrochloride; (2S,3aR,7aS)-1H-octahydroindole-2-carboxylic acid HCl; PONAUWFRJYNGAC-MWDCIYOWSA-N; (2S,3aR,7aS)-Octahydro-indole-2-carboxylic acid hydrochloride; SCHEMBL1041576; DTXSID60647571; AMY14951; FD7233; AKOS015915339; AC-8816; (2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylic acid--hydrogen chloride (1/1). Grades: > 95%. CAS No. 144540-75-0. Molecular formula: C9H15NO2.HCl. Mole weight: 205.69. | |
| Peritassine A | Peritassine A is a natural compound of the sesquiterpenoid class found in the roots of Tripterygium wilfordii Hook. f. Synonyms: Peritassine A; 262601-67-2; PeritassineA; FT-0775572. Grades: >98%. CAS No. 262601-67-2. Molecular formula: C38H47NO18. Mole weight: 805.783. | |
| Perylene Orange | Lumaogen F 40 is a fluorescent pigment. Synonyms: Lumaogen F 40. Grades: >98.0%. CAS No. 82953-57-9. Molecular formula: C48H42N2O4. Mole weight: 710.87. | |
| Perylene Red | Perylene Red is a fluorescent dye. Synonyms: Fluorescense red; Lumogen Red 300; KF-856; KF856; KF 856; N,N'-Bis(2,6-diisopropylphenyl)-1,6,7,12-tetraphenoxy-3,4,9,10-perylenetetracarboxylic Diimide. CAS No. 123174-58-3. Molecular formula: C72H58N2O8. Mole weight: 1079.2. | |
| Pevonedistat | Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. Uses: Enzyme inhibitors. Synonyms: TAK-924; TAK 924; TAK924; MLN4924; MLN 4924; BAY-73-4506; BAY 73-4506; BAY73-4506. Grades: ≥98% (HPLC). CAS No. 905579-51-3. Molecular formula: C21H25N5O4S. Mole weight: 443.52. | |
| Pexacerfont | Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress. Pexacerfont is a potent and orally active CRF-1 antagonist trials for the treatment of anxiety disorders, and has also been proposed to be useful for the treatment of depression and irritable bowel syndrome. Uses: Crf-1 antagonist. Synonyms: BMS-562086; BMS 562086; BMS562086; BMS-562,086; BMS562,086; BMS 562,086; Pexacerfont.8-(6-Methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-((1R)-1-methylpropyl)pyrazolo(1,5-a)-1,3,5-triazin-4-amine. Grades: ≥98%. CAS No. 459856-18-9. Molecular formula: C18H24N6O. Mole weight: 340.43. | |
| Pexiganan acetate | An antimicrobial peptide (AMP) that is effective against a broad spectrum of bacteria including aerobic and anaerobic, gram-positive and gram-negative. Synonyms: MSI 78; Pexiganan. Grades: >98%. CAS No. 172820-23-4. Molecular formula: C122H210N32O22.C2H4O2. Mole weight: 2537.22. | |
| PF-03758309 | PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival. Synonyms: PF03758309; PF 03758309; PF-3758309; PF3758309; PF 3758309. Grades: >98%. CAS No. 898044-15-0. Molecular formula: C25H30N8OS. Mole weight: 490.63. | |
| PF-04457845 | PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. Synonyms: PF-04457845; PF 04457845; PF04457845; PF-4457845; PF 4457845; PF4457845. Grades: >98%. CAS No. 1020315-31-4. Molecular formula: C23H20F3N5O2. Mole weight: 455.43. | |
| PF 05175157 | PF-05175157 is a selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 and isoform ACC2 dominant. IC50 values are 27 nM and 33 nM, respectively. It was originated by Pfizer. ACC inihibitors can inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids. In Feb 2015, Phase-II for Type-2 diabetes mellitus in USA was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PF-05175157; PF05175157; 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one. Grades: 98%. CAS No. 1301214-47-0. Molecular formula: C23H27N5O2. Mole weight: 405.50. | |
| PF-05231023 | PF-05231023 is a long-acting FGF21 mimic. PF-05231023 can reduce the weight of non-human primates and patients with type 2 diabetes and improve blood lipid status. It is a PEG-based PROTAC linker that can be used to synthesize PROTAC. Synonyms: Mal-Amido-PEG2-C2-Amido-Ph-C2-CO-AZD; 2, 5-Dihydro-2, 5-Dioxo-N- (2- (2- (3-Oxo-3- ( (4- (3-Oxo-3- (2-Oxo-1-Azetidinyl) Propyl) Phenyl) Amino) Propoxy) Ethoxy) Ethyl) -1H-Pyrrole-1-Propanamide; 2, 5-Dihydro-2, 5-Dioxo-N- [2- [2- [3-Oxo-3- [ [4- [3-Oxo-3- (2-Oxo-1-Azetidinyl) Propyl] Phenyl] Amino] Propoxy] Ethoxy] Ethyl] -1H-Pyrrole-1-Propanamide. Grades: ≥98% by HPLC. CAS No. 1037589-69-7. Molecular formula: C26H32N4O8. Mole weight: 528.6. | |
| PF 06424439 | PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Synonyms: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate; PF-06424439; PF06424439; PF 06424439; PF-6424439; PF-6424439; PF 6424439. Grades: ≥98% by HPLC. CAS No. 1469284-79-4. Molecular formula: C22H26ClN7O.CH4O3S. Mole weight: 536.05. | |
| PF-06471553 | PF-06471553, isoindoline-5-sulfonamide, selectively inhibits MGAT3 with high in vitro potency and cell efficacy which displayed suitable PK properties in mouse and in vivo MGAT3 inhibition in a transgenic mouse model. Synonyms: PF-06471553; PF 06471553; PF06471553; PF-6471553; PF 6471553; PF6471553. N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-(2-(3-methoxyphenyl)acetyl)isoindoline-5-sulfonamide. Grades: >98%. CAS No. 1808094-07-6. Molecular formula: C23H25N5O4S. Mole weight: 467.54. | |
| PF-06651600 | PF-06651600 is a selective JAK3 inhibitor with IC50 value of 0.346 nM. It was shown to inhibit Th1 and Th17 cell differentiation and function in vitro. Synonyms: Ritlecitinib; PF 06651600; PF06651600; 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-. Grades: >98%. CAS No. 1792180-81-4. Molecular formula: C15H19N5O. Mole weight: 285.351. | |
| PF-06840003 | PF-06840003 is a highly selective inhibitor of IDO1 (IC50 = 0.41mcM), an immunosuppressive enzyme induced by multiple cancers. Study in vitro showed that PF-06840003 led to IDO-1-induced T-cell anergy. Study in vivo revealed that it significantly suppressed tumor growth in combination with avelumab in mouse model. Uses: Antitumor drug. Synonyms: EOS200271, EOS-200271; EOS 200271; PF-06840003; PF 06840003; PF06840003. CAS No. 198474-05-4. Molecular formula: C12H9FN2O2. Mole weight: 232.21. | |
| PF-07321332 | PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants. Synonyms: PF 07321332; PF07321332. Grades: 98%. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.53. | |
| PF-3274167 | PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Synonyms: PF-03274167; PF 03274167; PF03274167; PF-3274167; PF 3274167; PF3274167. Grades: 98%. CAS No. 900510-03-4. Molecular formula: C19H19ClFN5O3. Mole weight: 419.84. | |
| PF 3644022 | PF 3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (IC50 = 5.2 nM; Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF 3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-onel; PF-3644022; PF 3644022; PF3644022. Grades: ≥98% by HPLC. CAS No. 1276121-88-0. Molecular formula: C21H18N4OS. Mole weight: 374.46. | |
| PF 3758309 dihydrochloride | PF 3758309 dihydrochloride is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 (IC50 = 1.3 nM; Kd = 2.7 nM). PF 3758309 inhibits phosphorylation of a natural PAK4 substrate in cells with an IC50 ~1 nM and inhibits anchorage-independent growth (expected biology for PAK4 inhibition) at 240 pM. Synonyms: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride; PF 3758309 dihydrochloride; PF3758309 dihydrochloride; PF-3758309 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H30N8OS.2HCl. Mole weight: 563.55. | |
| PF-4136309 | PF-4136309 is a potent, selective, and orally bioavailable antagonist of CCR2, a chemokine receptor of the super family of seven-transmembrane G-protein-coupled receptors (GPCRs). Synonyms: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide; PF4136309; PF 4136309; PF04136309; PF-04136309; INCB8761; INCB 8761; INCB-8761. CAS No. 1341224-83-6. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
| PF 429242 | PF 429242 is a reversible, competitive, cell permeable inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM) without disrupting a panel of serine proteases. Some studies reported that the inhibition of SKI-1/S1P, a master lipo- 387 genic regulator, could impair HCV genome replication, lipid droplet 388 homeostasis and the production of infectious HCV virions. Synonyms: PF-429242; PF 429242; PF429242. Benzamide, 4-[(diethylamino)?methyl]?-N-[2-(2-methoxyphenyl)?ethyl]?-N-(3R)?-3-pyrrolidinyl-; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide. CAS No. 947303-87-9. Molecular formula: C25H35N3O2. Mole weight: 409.56. | |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Synonyms: PF-429242 dihydrochloride; PF429242 dihydrochloride. Grades: ≥97% by HPLC. CAS No. 2248666-66-0. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. | |
Our database is helping our users find suppliers everyday.
