BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Sitagliptin EP Impurity B | Sitagliptin EP Impurity B is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Analog 13; 4-Desfluoro Sitagliptin; (R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,5-difluorophenyl)butan-2-amine. Grades: > 95%. CAS No. 486460-31-5. Molecular formula: C16H16F5N5O. Mole weight: 389.32. |  |
| Sitagliptin EP Impurity B Phosphate | Sitagliptin EP Impurity B Phosphate is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Analog 13 Phosphate; 4-Desfluoro Sitagliptin Phosphate; (R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,5-difluorophenyl)butan-2-amine phosphate. CAS No. 1345822-87-8. Molecular formula: C16H19F5N5O5P. Mole weight: 487.32. | |
| Sitagliptin EP Impurity C | Sitagliptin EP Impurity C is a impurity of Sitagliptin. Sitagliptin is an dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: 5-Desfluoro Sitagliptin; (R)-3-amino-4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one. CAS No. 945261-48-3. Molecular formula: C16H16F5N5O. Mole weight: 389.32. | |
| Sitagliptin EP Impurity C Phosphate | Sitagliptin EP Impurity C Phosphate is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: 5-Desfluoro Sitagliptin Phosphate; (R)-3-Amino-4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one-phosphate. CAS No. 1345822-86-7. Molecular formula: C16H19F5N5O5P. Mole weight: 487.32. | |
| Sitagliptin FP Impurity B | Sitagliptin FP Impurity B is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Triazecine Impurity; Sitagliptin Triazecine Analog; (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione. Grades: >95%. CAS No. 2088771-61-1. Molecular formula: C16H13F6N5O2. Mole weight: 421.3. | |
| Sitagliptin FP Impurity C | Sitagliptin FP Impurity C is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: 3-Desamino-3,4-dehydro Sitagliptin; Sitagliptin Styrylacetyl Analog; (3E)-1-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)but-3-en-1-one. Grades: >95%. CAS No. 1803026-58-5. Molecular formula: C16H12F6N4O. Mole weight: 390.28. | |
| Sitagliptin FP Impurity D | Sitagliptin FP Impurity D is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Deamino Impurity 1; 3-Desamino-2,3-dehydro Sitagliptin; (2E)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one. Grades: >90%. CAS No. 1253056-18-6. Molecular formula: C16H12F6N4O. Mole weight: 390.28. | |
| Sitagliptin FP Impurity E Hydrochloride | Sitagliptin EP Impurity E is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Impurity 17 HCl; Sitagliptin Acid Impurity HCl; (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride; (βR)-β-Amino-2,4,5-trifluorobenzenebutanoic Acid Hydrochloride. Grades: >95%. CAS No. 1204818-19-8. Molecular formula: C10H11ClF3NO2. Mole weight: 269.65. | |
| Sitagliptin Fumarate Adduct (Mixture of Diastereomers) | Sitagliptin Fumarate Adduct is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Tablets EP Impurity FP-A; Sitagliptin FP Impurity A; N-[(1R)-3-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-L-Aspartic acid; Sitagliptin Maleate adduct. Grades: 95%. CAS No. 2088771-60-0. Molecular formula: C20H19F6N5O5. Mole weight: 523.39. | |
| Sitagliptin Impurity 40 HCl | Sitagliptin Impurity 40 HCl is an impurity of Sitagliptin. Sitagliptin is an dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: methyl (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate, hydrochloride (1:1); (R)-Methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate hydrochloride; Methyl (R)-beta-Amino-2,4,5-F3-benzenebutanoate HCl. CAS No. 1374985-05-3. Molecular formula: C11H12F3NO2.HCl. Mole weight: 283.67. | |
| Sitagliptin impurity D | Cas No. 1379666-94-0. | |
| Sitagliptin Phosphate Monohydrate | Sitagliptin Phosphate Monohydrate is the phosphate salt form of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: MK-0431 phosphate monohydrate; 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate. Grades: >98%. CAS No. 654671-77-9. Molecular formula: C16H20F6N5O6P. Mole weight: 523.32. | |
| Sitamaquine tosylate | Sitamaquine tosylate is a dose-dependent and orally bioactive inhibitor of complex II (succinate dehydrogenase or SDH) of the respiratory chain in digitonin-permeabilized promastigotes. Sitamaquine has the potential for the treatment of life-threatening visceral leishmaniasis (VL) caused by Leishmania donovani (EC50 value 19.8 μM for L. donovani promastigotes in vitro). Synonyms: WR6026 tosylate; WR-6026 tosylate; WR 6026 tosylate. Grades: 99%. CAS No. 1019640-33-5. Molecular formula: C21H33N3O.C7H8O3S. Mole weight: 515.71. | |
| SK1-IN-1 | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor (IC50 = 58 nM). Synonyms: (2S,3S)-N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxypyrrolidine-2-carboxamide. CAS No. 1218816-71-7. Molecular formula: C22H30N4O3. Mole weight: 398.5. | |
| SKF 89976A hydrochloride | Cas No. 85375-15-1. | |
| SKF 91488 dihydrochloride | SKF 91488 dihydrochloride is a potent inhibitor of histamine N-methyltransferase with no histamine agonist activity. SKF 91488 is used in the treatment of depression, anxiety and Parkinson's disease. Uses: The treatment of depression, anxiety and parkinson's disease. Synonyms: SKF 91488 dihydrochloride; SKF91488 dihydrochloride; SKF-91488 dihydrochloride; 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride. CAS No. 68941-21-9. Molecular formula: C7H17N3S.2HCl. Mole weight: 248.21. | |
| SKF-96365 | SKF-96365, a store-operated Ca2+ entry inhibitor, has been found to restrain the depolarization of circular smooth muscle caused by acetylcholine and also exhibit antineoplastic activity through leading to cells apoptosis. It has been already discontinued. Uses: Skf-96365 is a store-operated ca2+ entry inhibitor that has been found to restrain the depolarization of circular smooth muscle caused by acetylcholine and also exhibit antineoplastic activity through leading to cells apoptosis. Synonyms: SKF-96365; SKF 96365; SKF96365; 1-[2- (4-Methoxyphenyl) -2-[3- (4-methoxyphenyl) propoxy]ethyl]imidazole, 1-[-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride. Grades: 95%. CAS No. 130495-35-1. Molecular formula: C22H27ClN2O3. Mole weight: 402.91. | |
| SKI 178 | SKI 178 is a non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM) used for the treatment of AML. SKI 178 has been shown to induce CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Uses: Aml treatment. Synonyms: SKI-178; SKI 178; SKI178. N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Grades: ≥98% by HPLC. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.42. | |
| SKI II | 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins. Synonyms: SphK-I2; SKI-II; SKI II. Sphingosine kinase inhibitor II. Grades: >98%. CAS No. 312636-16-1. Molecular formula: C15H11ClN2OS. Mole weight: 302.78. | |
| Skp2 Inhibitor C1 | Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. Synonyms: MDK-1699; MDK 1699; MDK1699; Skp2 inhibitor C1 and SKPin C1. Grades: >98%. CAS No. 432001-69-9. Molecular formula: C18H13BrN2O4S2. Mole weight: 465.34. | |
| (S)-KT109 | (S)-KT109 is the S isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109. Synonyms: (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2S)-2-(phenylmethyl)-1-piperidinyl]-methanone; [(2S)-2-benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone. Grades: ≥98%. CAS No. 2055172-61-5. Molecular formula: C27H26N4O. Mole weight: 422.52. | |
| SLC-0111 | SLC-0111, also known as U-104, MST-104 and NSC 213841, is a potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models. Synonyms: 4- (3- (4-fluorophenyl) ureido) benzenesulfonamide; SLC-0111; SLC0111; SLC 0111; MST-104; MST-104; MST-104; NSC-213841; NSC213841; NSC 213841; U-104; U104; U 104. CAS No. 178606-66-1. Molecular formula: C13H12FN3O3S. Mole weight: 309.31. | |
| SLC5111312 hydrochloride | SLC5111312 is a dual inhibitor of sphingosine kinase 1 (SPHK1) and SPHK2. Synonyms: (2S,3S)-3-hydroxy-2-[3-[6-(pentyloxy)-2-naphthalenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide monohydrochloride. Grades: ≥98%. CAS No. 1870811-01-0. Molecular formula: C22H27N5O3·HCl. Mole weight: 445.94. | |
| SLF | SLF is a cell-permeable analog of FK-506, an immunosuppressant with high affinity for FK-506 binding protein 12 (FKBP12). SLF binds tightly to FKBP but lacks the ability to inhibit calcineurin. Synonyms: SLF Exclusive; Synthetic Ligand of FKBP. Grades: ≥98%. CAS No. 195513-96-3. Molecular formula: C30H40N2O6. Mole weight: 524.66. | |
| SLM 6031434 | SLM 6031434 is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2), displaying 40-fold selectivity for Sphk2 over Sphk1. Synonyms: (2S)-2-[3-[4-Octoxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide. Grades: ≥98%. CAS No. 1897379-33-7. Molecular formula: C22H30F3N5O2. Mole weight: 453.5. | |
| SLM 6031434 hydrochloride | SLM 6031434 is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2), displaying 40-fold selectivity for Sphk2 over Sphk1. Synonyms: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1897379-34-8. Molecular formula: C22H30F3N5O2·HCl. Mole weight: 489.96. | |
| SLP120701 HCl | The hydrochloride salt form of SLP120701, an oxadiazol derivative, has been found to be a Sphk inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Uses: The hydrochloride salt form of slp120701 has been found to be a sphk inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Synonyms: (S)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboximidamide hydrochloride; SLP120701; SLP-120701; SLP120701. Grades: 98%. CAS No. 1449768-46-0. Molecular formula: C20H30ClN5O. Mole weight: 391.94. | |
| SLP7111228 hydrochloride | SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 μM for SPHK1 and 2, respectively. It depressed blood levels of S1P in a dose-dependent manner in rats. Synonyms: SLP7111228 Hydrochloride. Grades: ≥95%. CAS No. 1449768-48-2. Molecular formula: C22H34ClN5O. Mole weight: 419.99. | |
| SLR080811 | SLR080811, an oxadiazol derivative, has been found to be a SphK inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Uses: Slr080811 has been found to be a sphk inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Synonyms: SLR080811; SLR080811; SLR 080811; (R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride. Grades: 98%. CAS No. 1449765-65-4. Molecular formula: C21H31N5O. Mole weight: 406.00. | |
| SLR080811 HCl | The hydrochloride salt form of SLR080811, an oxadiazol derivative, has been found to be a SphK inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Uses: Slr080811 hcl has been found to be a sphk inhibitor and could probably be useful in studies of some cancer, fibrosis, and sickle cell diseases. Synonyms: SLR080811 HCl; SLR 080811 HCl; SLR-080811 HCl; SLR080811 hydrochloride; SLR 080811 HCl; 1-Pyrrolidinecarboximi?damide, 2-[3-(4-octylphenyl)?-1,?2,?4-oxadiazol-5-yl]?-, hydrochloride. Grades: 98%. CAS No. 1449768-36-8. Molecular formula: C21H32ClN5O. Mole weight: 369.50. | |
| SM-102 | SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles which is used in the Moderna COVID-19 vaccine. Synonyms: 1-Octylnonyl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate. Grades: 95%. CAS No. 2089251-47-6. Molecular formula: C44H87NO5. Mole weight: 710.16. | |
| SMCC | SMCC is a heterobifunctional protein crosslinker for antibody-drug-conjugation (ADC). Synonyms: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid N-Hydroxysuccinimide Ester; NSC 344483; N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester; 1H-Pyrrole-2,5-dione, 1-[[4-[[ (2, 5-dioxo-1-pyrrolidinyl) oxy]carbonyl]cyclohexyl]methyl]-; 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate; 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-ylmethyl)-cyclohexanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester; N-Hydroxysuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate; N-Succinimidyl 4- (maleimidomethyl) cyclohexanecarboxylate; Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate; Succinimidyl 4- (N-maleimidomethyl) cyclohexanecarboxylate; Succinimidyl 4-[maleimidomethyl]cyclohexan-1-carboxylate. Grades: ≥95%. CAS No. 64987-85-5. Molecular formula: C16H18N2O6. Mole weight: 334.32. | |
| SMDC818909 | This active molecular is a selective p97 inhibitor. The IC50 value of it decreased with increasing ATP concentration. IC50 value is 26.0 ± 0.9μM in 5μM ATP, 11.5 ± 0.9μM in 5μM ATP, 4.9 ± 0.9 μM in 100 μM ATP. These data indicated that SMDC818909 behaved primarily uncompetitively with the ATP substrate. SMDC818909 represents a novel uncompetitive inhibitor whicn can be applicated as a starting point for drug discovery. Uses: Used as a starting point for drug discovery. Synonyms: SMDC818909; SMDC 818909; SMDC-818909. 3-amino-N-(2-methyl-1H-indol-5-yl)pyrazine-2-carboxamide. Grades: 98%. CAS No. 1147823-21-9. Molecular formula: C14H13N5O. Mole weight: 267.29. | |
| (S)-Metoprolol | (S)-Metoprolol is the (S)-Enantiomer of Metoprolol, a β1 receptor blocker medication. Synonyms: (2S)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol; (-)-Metoprolol; (S)-(-)-Metoprolol. Grades: > 95%. CAS No. 81024-42-2. Molecular formula: C15H25NO3. Mole weight: 267.36. | |
| SMI-16a | SMI-16a, a cell-permeable thiazolidinedione compound, is a selective and ATP-competitive Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively. Synonyms: Pim1/2 Inhibitor IV; PIM1/2 Kinase Inhibitor VI; Pim1/2 Kinase Inhibitor IV; SMI-16a. (5Z)-5-[(4-propoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione; ST50842732; (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione; 5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione; (5Z)-5-(4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione. CAS No. 587852-28-6. Molecular formula: C13H13NO3S. Mole weight: 263.31. | |
| SMI 481 | SMI 481 is a small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer proteins (PITP) Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI 481 exhibits exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. Synonyms: SMI481; SMI-481 SMI 481; NPPM 6748-481; NPPM 6748481; NPPM6748481; NPPM-6748-481; (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone; 1-(4-chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)piperazine; (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)piperazin-1-yl]methanone. Grades: 99%. CAS No. 432020-20-7. Molecular formula: C17H15ClFN3O3. Mole weight: 363.77. | |
| SMI-4a | SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM against Pim-1 and 100 nM against Pim-2) with little or no activity against a panel of 58 other kin. Synonyms: SMI-4a; SMI 4a; SMI4a; (5E)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dioneTCS-PIM-1-4aMS-1740; MS 1740; MS1740327033-36-35-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione. CAS No. 327033-36-3. Molecular formula: C11H6F3NO2S. Mole weight: 273.20. | |
| SMIFH2 | SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. SMIFH2 prevents formin-mediated actin nucleation and barbed end elongation, disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts. Synonyms: SMIFH-2; SMIFH 2; SMIFH2; 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione; (5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione. Grades: ≥99% by HPLC. CAS No. 340316-62-3. Molecular formula: C15H9BrN2O3S. Mole weight: 377.21. | |
| SMND-309 | SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo. Synonyms: SMND-309; SMND 309; SMND309. Grades: >98%. CAS No. 1065559-56-9. Molecular formula: C18H14O8. Mole weight: 358.3. | |
| SNAP-8 | SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation and preventing the formation of lines and wrinkles. Synonyms: Snap-8 Acetyl Octapeptide-3; SNAP8; SNAP 8. Grades: >98%. CAS No. 868844-74-0. Molecular formula: C41H70N16O16S. Mole weight: 1075.16. | |
| SNAP 94847 | SNAP 94847 hydrochloride is a potent and orally bioactive melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM; KD=530 pM), displaying > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. SNAP 94847 was indicated ability to increase neurogenesis in the dentate gyrus and decrease food-reinforced operant responding in vivo. Synonyms: SNAP-94847; SNAP 94847; SNAP94847; N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 487051-12-7. Molecular formula: C29H32F2N2O2. Mole weight: 478.57. | |
| SNAP 94847 hydrochloride | SNAP 94847 is a potent melanin-concentrating hormone receptor 1 (MCH1) antagonist with > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Synonyms: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1781934-47-1. Molecular formula: C29H32F2N2O2·HCl. Mole weight: 515.03. | |
| SNDX-5613 | SNDX-5613 is a potent and specific Menin-MLL inhibitor. It can be used to study MLL rearrangement (MLL-r) acute leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Synonyms: SNDX 5613; SNDX5613. Grades: ≥98% by HPLC. CAS No. 2169919-21-3. Molecular formula: C32H47FN6O4S. Mole weight: 630.82. | |
| Sobetirome | Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. Treatment of hypercholestemia obesity, and thyroid proliferative disorders. Synonyms: GC-1; GC1; GC 1; QRX-431; QRX 431; QRX431; Sobetirome. Grades: >98%. CAS No. 211110-63-3. Molecular formula: C20H24O4. Mole weight: 328.4. | |
| (S)-O-Demethylmetoprolol | (S)-O-Demethylmetoprolol is an impurity of Betaxolol, which is a selective beta1 adrenergic receptor blocker for the treatment of hypertension and glaucoma. Synonyms: O-Demethylmetoprolol, (-)-; (S)-(-)-O-Demethylmetoprolol. CAS No. 131564-69-7. Molecular formula: C14H23NO3. Mole weight: 253.342. | |
| Sodium 1-dodecanesulfonate | Sodium 1-dodecanesulfonate (CAS# 2386-53-0) is a useful research chemical. Uses: Alkane sulfonates: used in liquid detergents, concentrated shampoos, textile and leather auxiliaries (mercerising), metal cleaning preparations, steam jets, and pickling bathes. Synonyms: sodium;dodecane-1-sulfonate. Grades: > 98.0 % (T). CAS No. 2386-53-0. Molecular formula: C12H25NaO3S. Mole weight: 272.38. | |
| Sodium 1-hexanesulfonate monohydrate | Sodium 1-hexanesulfonate monohydrate is a useful research chemical. Synonyms: 1-Hexanesulfonic acid sodium salt monohydrate. Grades: 95 %. CAS No. 207300-91-2. Molecular formula: C6H15NaO4S. Mole weight: 206.24. | |
| Sodium 2-((2S,5S)-5-benzyl-3,6-dioxopiperazin-2-yl)acetate | Synonyms: 2-Piperazineacetic acid, 3,6-dioxo-5-(phenylmethyl)-, sodium salt (1:1), (2S,5S)-; 2-Piperazineacetic acid, 3,6-dioxo-5-(phenylmethyl)-, monosodium salt, (2S-cis)-. Grades: 95%. CAS No. 136983-81-8. Molecular formula: C13H13N2NaO4. Mole weight: 284.24. | |
| Sodium 3-hydroxybenzenesulfonate | Sodium 3-hydroxybenzenesulfonate, an organic chemical commonly employed in medicinal production and synthetic processes, exerts potent anti-inflammatory and analgesic actions. Such biochemical interventions are found efficacious in countering a panoply of afflictions including pain, fever, and inflammation symptomatic of arthritis and rheumatoid disorders. Synonyms: sodium 3-hydroxybenzenesulfonate; Sodium m-phenolsulfonate. CAS No. 14278-60-5. Molecular formula: C6H5NaO4S. Mole weight: 196.16. | |
| Sodium 4-pentynoate | Sodium 4-pentynoate, an alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types. Synonyms: sodium 4-pentynoate; 101917-30-0; sodium pent-4-ynoate; sodium; pent-4-ynoate; sodium4-pentynoate; CS-0723; SCHEMBL3503732; DTXSID70735352; BCP33409; AKOS030526202; AS-57204; HY-15286; D86943; EN300-178227. Grades: >98%. CAS No. 101917-30-0. Molecular formula: C5H5NaO2. Mole weight: 120.08. | |
| Sodium Aescinate | Sodium aescinate, which is isolated from the herbs of Aesculus hippocastanum L, has immunity enhancing effects. Besides, it may effectively control and improve wound healing in diabetic rats via its anti-inflammatory and antioxidant activities. Sodium Aescinate can protect the lung injury induced by intestinal ischemia/reperfusion (I/R), which may be mediated by inhibiting lipid peroxidation, upregulating Bcl-2 gene protein expression, improving the ratio of Bcl-2/ Bax to inhibit lung apoptosis. Uses: Anti-inflammatory / antioxidative / antiedematous. Synonyms: Sodium escinate. Grades: 95% (mixture of isomers). CAS No. 20977-05-3. Molecular formula: C55H86NaO24. Mole weight: 1154.25. | |
| Sodium diethyl phosphate | Sodium diethyl phosphate can be used in a cosmetic composition for treating keratin materials. Synonyms: Diethyl Phosphate Sodium Salt; Phosphoric acid, diethyl ester, sodium salt. CAS No. 2870-30-6. Molecular formula: C4H10NaO4P. Mole weight: 176.08. | |
| Sodium formononetin-3(acute)-sulfonate | Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin. It has a protective potential against myocardial infarction injury. It not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities. Synonyms: Sul-F. Grades: >98%. CAS No. 949021-68-5. Molecular formula: C16H11NaO7S. Mole weight: 370.31. | |
| Sodium metatungstate hydrate | POM 1 is a polyoxometalate that inhibits ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) 1 and 3 with Ki values of 2.58 and 3.26 μM, respectively. Synonyms: Sodium Metatungstate; Sodium Polyoxotungstate. Grades: ≥95%. CAS No. 314075-43-9. Molecular formula: Na6O39W12·H2O. Mole weight: 2986.1. | |
| Sodium Nitroprusside | Sodium Nitroprusside is a potent vasodilator working through releasing NO spontaneously in blood. Grades: >98%. CAS No. 14402-89-2. Molecular formula: C5FeN6O.2Na. Mole weight: 261.92. | |
| Sodium orthovanadate | Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. Synonyms: Sodium orthovanadate; 13721-39-6; Trisodium vanadate; Sodium o-vanadate; Sodium pervanadate; Sodium vanadate (ortho); Trisodium tetraoxovanadate; Sodium vanadium oxide (Na3VO4); Sodium tetraoxovanadate(3-); Vanadic acid, trisodium salt; TRISODIUM ORTHOVANADATE; Vanadic acid (H3VO4), sodium salt; trisodium trioxido(oxo)vanadium; trisodium; trioxido(oxo)vanadium; Sodium vanadate(V) (Na3VO4); 7845MV6C8V; MFCD00003511; CCRIS 9063; EINECS 237-287-9; NSC 79534; Vanadyl; UNII-7845MV6C8V; Vanadate (VO43-), trisodium, (T-4)-; AI3-52157; Vanadate(VO4(3-)), trisodium; sodiumorthovanadate; Sodium Ortho Vanadate; Na3VO4; Vanadate (VO43-), trisodium, (beta-4)-; sodium tetraoxidovanadate(V); sodium tetraoxidovanadate(3-); DTXSID2037269; CHEBI:35607; IHIXIJGXTJIKRB-UHFFFAOYSA-N; vanadate (VO4(3-)), trisodium; s2000; AKOS004910370; SODIUM ORTHOVANADATE (NA3VO4); CCG-266460; Sodium orthovanadate, >=90% (titration); FT-0688138; E75940; Sodium orthovanadate, 99.98% trace metals basis; J-006982; Q2156566. Grades: >98%. CAS No. 13721-39-6. Molecular formula: Na3O4V. Mole weight: 183.91. | |
| sodium polyglutamate | Sodium polyglutamate is a zwitterionic surfactant with excellent film formation, lubrication, dispersion, penetration and performance. Sodium polyglutamate is used as an emulsifier and dispersant in cosmetics. CAS No. 28829-38-1. Molecular formula: (C5H73)n.xNa. | |
| Sodium (R)-alpha-lipoate | Sodium (R)-alpha-lipoate, a robust antioxidant, is efficaciously exploited to rectify diabetic neuropathy. By enhancing glucose metabolism and curtailing oxidative stress, sodium (R)-alpha-lipoate averts nerve damage. Additionally, research illustrates its prospective role in remedying Alzheimer's disease and multiple sclerosis. Synonyms: Sodium (R)-lipoate; 1,2-Dithiolane-3-pentanoic acid, sodium salt, (R)-; Sodium (R)-5-(1,2-dithiolan-3-yl)pentanoate; 1,2-Dithiolane-3-pentanoic acid, sodium salt, (3R)- (1:1); (R)-lipoic acid sodium salt; R-(+)-alpha-Lipoic acid sodium salt. Grades: ≥95%. CAS No. 176110-81-9. Molecular formula: C8H13NaO2S2. Mole weight: 228.31. | |
| Sonidegib | Sonidegib is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. It was approved by the FDA for treating basal-cell carcinoma in July 2015. Synonyms: Erismodegib; LDE225; NVP-LDE225; Odomzo; N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide. Grades: >98%. CAS No. 956697-53-3. Molecular formula: C26H26F3N3O3. Mole weight: 485.507. | |
| Sonoflora 1 | Sonoflora 1, a kind of PDT photosensitivizer, was once studied against breast cancer and the Phase I/II trial has been already discontinued by SonneMed. Synonyms: Sonoflora 1; Sonoflora1; Sonoflora-1; SF1; SF-1; SF 1; Stannate(3-)?, [N-[2-[(7S, ?8S)?-3-carboxy-7-(2-carboxyethyl)?-13-ethenyl-18-ethyl-2, ?8, ?12, ?17-tetramethyl-21H, ?23H-porphin-5-yl-κ N21, ?κ N22, ?κ N23, ?κ N24]?acetyl]?glycylglycinato(5-). Grades: 98%. CAS No. 1609250-37-4. Molecular formula: C38H42N6O10Sn. Mole weight: 861.48. | |
| Sophoflavescenol | Sophoflavescenol is a compound of the flavonoid class found in the roots of Sophora flavescens Ait. Sophoflavescenol is a PDE5 inhibitor with antioxidant and anti-inflammatory properties. Synonyms: 3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)chromen-4-one. Grades: >98%. CAS No. 216450-65-6. Molecular formula: C21H20O6. Mole weight: 368.385. | |
| Sophorabioside | Sophorabioside is a compound of the flavonoid class found in the seeds of Sophora japonica. Synonyms: 3-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxyphenyl]-5,7-dihydroxychromen-4-one. Grades: >98%. CAS No. 2945-88-2. Molecular formula: C27H30O14. Mole weight: 578.523. | |
| Soraprazan | Soraprazan, also known as BY359, is a reversible, and fast-acting inhibitor of gastric H+/K+ ATPase, used as anti-secretory drug. Synonyms: (7R,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridin-8-ol; (7R,8R,9R)-7-(2methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo(1,2-H)(1,7)naphtyridin-8-ol; 2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo(1,2-h)(1,7)naphthyridine; BYK 61359; BYK-61359; BYK61359; remofuscin; soraprazan. CAS No. 261944-46-1. Molecular formula: C21H25N3O3. Mole weight: 367.44. | |
| Sortin1 | Sortin1 is a synthetic chemical ats as a Sorting inhibitor, redirecting the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis. Uses: Sorting inhibitor. Synonyms: Sortin1; Sortin-1; Sortin 1; 4-(5-[3-(Methoxycarbonyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-B]pyridin-4-yl]-2-furyl)benzoic acid;4-[5-(3-methoxycarbonyl-2-methyl-5-oxo-1,4-dihydroindeno[1,2-b]pyridin-4-yl)furan-2-yl]benzoic acid. Grades: ≥95%. CAS No. 503837-98-7. Molecular formula: C26H19NO6. Mole weight: 441.43. | |
| Soticlestat | Soticlestat is a cholesterol 24-hydroxylase (CYP46A1) inhibitor with the potential to reduce seizure susceptibility and improve seizure control. Synonyms: OV935; TAK-935. Grades: 98%. CAS No. 1429505-03-2. Molecular formula: C23H23N3O2. Mole weight: 373.4. | |
| Soyasaponin I | Soyasaponin I is extracted from the seeds of Glycine max. It can exhibit reverse effects on over expression of c-met, VEGF in Eca-9706 cells. Synonyms: β-D-Glucopyranosiduronic acid, (3β,4β,22β)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-Mannopyranosyl-(1?2)-O-β-D-galactopyranosyl-(1?2)-; Soyasaponin Bb. Grades: >98%. CAS No. 51330-27-9. Molecular formula: C48H78O18. Mole weight: 943.134. | |
| Soyasaponin II | Soyasaponin II is found in Glycine max, it shows antiviral effects. Synonyms: Soyasaponin Bc; Soyasaponin B-II; Soysaponin II. Grades: > 95%. CAS No. 55319-36-3. Molecular formula: C47H76O17. Mole weight: 913.09. | |
| (S)-p38 MAPK Inhibitor III | (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively). Synonyms: (S)-p38 MAP Kinase Inhibitor III; 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamin; (S)-p38 Mitogen-activated Protein Kinase Inhibitor III. Grades: ≥98%. CAS No. 581098-48-8. Molecular formula: C23H21FN4S. Mole weight: 404.5. | |
| SP-420 | SP-420 is a desferrithiocin analogue with iron-clearing efficiency. Its ICE value is 26.7. It is more potent than desferrithiocin. Uses: Sp-420 has iron-clearing effect. Synonyms: SP-420; SP420; SP 420; (4S)-4,5-Dihydro-2-[2-hydroxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid. Grades: >98%. CAS No. 911714-45-9. Molecular formula: C16H21NO6S. Mole weight: 355.41. | |
| Sp-5,6-dichloro-cBIMPS sodium salt | Sp-5,6-dichloro-cBIMPS is a potent and selective activator of protein kinase A (PKA). Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases. Synonyms: Sp-5,6-DCI-cBIMPS; 5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt. Grades: ≥99%. CAS No. 142439-96-1. Molecular formula: C12H10Cl2N2O5PS·Na. Mole weight: 419.1. | |
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