BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| (R)-Metoprolol | (R)-Metoprolol is the (R)-Enantiomer of Metoprolol, a β1 receptor blocker medication. Synonyms: (2R)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol; (+)-Metoprolol; (R)-(+)-Metoprolol. Grades: > 95%. CAS No. 81024-43-3. Molecular formula: C15H25NO3. Mole weight: 267.36. |  |
| (R)-MG132 | (R)-MG-132 is a reversible, cell permeable and selective tripeptide aldehyde proteasome inhibitor (IC50 = 0.22 μM), the most potent stereoisomer of MG-132. It exhibits cytostatic and cytotoxic effects in tumor cells in vitro. Synonyms: (R)-MG132; (R)-MG 132; MolPort-009-019-420; Cbz-L-leu-D-leu-L-leu-H; KS-000006AS; N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide. Grades: ≥97% by HPLC. CAS No. 1211877-36-9. Molecular formula: C26H41N3O5. Mole weight: 475.62. | |
| RMM 46 | RMM 46 is a reversible covalent inhibitor that exhibits high ligand efficiency and selectivity for MSK/RSK-family kinases. It shows selectivity for RSK2 over NEK2 and PLK1 (IC50s= 12, 530 and 2200 nM, respectively). Synonyms: RMM-46; RMM 46; RMM46; 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide. Grades: ≥98% by HPLC. CAS No. 1307896-46-3. Molecular formula: C24H26N4O5. Mole weight: 450.5. | |
| R-Morinidazole | R-Morinidazole is the R enantiomer of Morinidazole, wich is a novel 5-nitroimidazole antimicrobial drug. It undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. It is used in the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria. Uses: R-morinidazole is used in the treatment of bacterial infections including appendicitis and pelvic inflammatory disease (pid) caused by anaerobic bacteria. Synonyms: (R)-1-(2-Methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;(2R)-1-(2-methyl-5-nitroimidazol-1-yl)-3-morpholin-4-ylpropan-2-ol;Morinidazole R enantiomer. Grades: >98%. CAS No. 898230-59-6. Molecular formula: C11H18N4O4. Mole weight: 270.29. | |
| (R)-(-)-muscone | Synonyms: Cyclopentadecanone, 3-methyl-, (3R)-; UPS3C6CV36; (-)-3-Methylcyclopentadecanone; (3R)-3-methylcyclopentadecan-1-one. CAS No. 10403-00-6. Molecular formula: C16H30O. Mole weight: 238.415. | |
| RN 1 dihydrochloride | RN 1 is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM), which exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50= 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). It blocks long-term but not short-term memory in mice following intraperitoneal administration. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. Synonyms: RN 1 dihydrochloride; RN-1 dihydrochloride; RN1 dihydrochloride; 1- (4-methyl-1-piperazinyl) -2-[[ (1R*, 2S*) -2-[4-phenylmethoxy) phenyl]cyclopropyl]amino]ethanone dihydrochloride; RN-1, monohydrochloride; RN-1 2HCl. Grades: ≥97% by HPLC. CAS No. 1781835-13-9. Molecular formula: C23H29N3O2.2HCl. Mole weight: 452.42. | |
| (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine | (R)-(-)-N-(3,5-Dinitrobenzoyl)-alpha-phenylglycine, a vital compound, serves as an essential precursor in the pharmaceutical synthesis used to treat different maladies. This compound has demonstrated the property of improving the functioning of GABAergic neurotransmission, which makes it a promising therapeutic agent for combating anxiety and depression. Its potential in treating various mood disorders is a subject of ongoing scientific inquiry. Synonyms: N-(3,5-Dinitrobenzoyl)phenylglycine; DNBPG. Grades: >98.0%(LC)(T). CAS No. 74927-72-3. Molecular formula: C15H11N3O7. Mole weight: 345.26. | |
| (R)-N-Methyl-Laudanosine benzene sulfonate | An impurity of Laudanosine, which is a metabolite of Atracurium. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Grades: 95%. CAS No. 155913-37-4. Molecular formula: C28H35NO7S. Mole weight: 529.654. | |
| Ro 1138452 hydrochloride | Ro 1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Synonyms: Ro 1138452 hydrochloride; Ro1138452 hydrochloride; Ro-1138452 hydrochloride; 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride; Ro 1138452 Hcl. Grades: ≥98% by HPLC. Molecular formula: C19H23N3O.HCl. Mole weight: 345.87. | |
| Ro18-5362 | Ro18-5362 is the less active prodrug of Ro 18-5364 which is an extremely potent and rapid inhibitor of the gastric mucosal (H+ + K+)-ATPase. Synonyms: 2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfanyl]-5,5,7,7-tetramethyl-3H-cyclopenta[f]benzimidazol-6-one; Ro-18-5362. CAS No. 101387-97-7. Molecular formula: C22H25N3O2S. Mole weight: 395.52. | |
| Ro 20-1724 | Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. Synonyms: Ro20-1724; Ro 20-1724; Ro-20-1724. 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone; 4-[(3-Butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone; 4-(3-Butoxy-4-methoxy benzyl)-2-imidazolidinone; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidone; DL-4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Roche 20-1724. Grades: ≥99% by HPLC. CAS No. 29925-17-5. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| Ro 41-?3290 | Ro 41-3290, a desethylated metabolite of Ro 41-3696, has shown to be also a partial agonist at the benzodiazepine receptor. Synonyms: 10-chloro-1-[(3S)-3-hydroxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydrobenzo[a]quinolizin-4-one; Ro 41-3290; Ro-41-3290. CAS No. 143943-72-0. Molecular formula: C24H21ClN2O3. Mole weight: 420.89. | |
| RO-46-8443 | RO-46-8443, a benzenesulfonamide derivative, has been found to be a non-peptide endothelin ETB receptor antagonist and could probably be useful in some biological studies of ETB receptors in pathology. Synonyms: RO 46-8443; RO46-8443; RO-46-8443; RO 468443; RO-468443; RO468443; RO 46,8443; RO-46,8443; RO46,8443. 4-tert-butyl-N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl]benzenesulfonamide; AC1NSM3O; SCHEMBL795046; GTPL1011; Ro 46-8443. Grades: 98%. CAS No. 175556-12-4. Molecular formula: C31H35N3O8S. Mole weight: 609.69. | |
| Ro 48-8071 | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro-48-8071. Grades: >98%. CAS No. 161582-11-2. Molecular formula: C23H27BrFNO2. Mole weight: 448.37. | |
| Ro 48-8071 fumarate | Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Synonyms: Ro 48-8071; Ro48-8071; Ro-48-8071; Ro 488071; Ro488071; Ro-488071. Grades: >98%. CAS No. 189197-69-1. Molecular formula: C27H31BrFNO6. Mole weight: 564.44. | |
| RO 5263397 | RO5263397 is a selective trace amine-associated receptor 1(TAAR1) agonist. TAAR1 is a drug discovery target for cocaine addiction. RO5263397 is efficacious in reducing cocaine-mediated behaviors and it can dose-dependently prevent cocaine-induced lowering of ICSS thresholds. Uses: Cocaine addiction. Synonyms: RO 5263397; RO5263397; RO-5263397; (4S)?-4-(3-Fluoro-2-methylphenyl)?-4,?5-dihydro-2-oxazolamine. Grades: 98%. CAS No. 1357266-05-7. Molecular formula: C10H11FN2O. Mole weight: 194.21. | |
| Ro 6842262 | Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM) with >1,200-fold selectivity for LPA1 over LPA3. Synonyms: RO-6842262;RO 6842262; RO6842262; 1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1396006-71-5. Molecular formula: C28H26N4O4. Mole weight: 482.53. | |
| RO8191 | RO8191 is an agonist of interferon α receptor type 2 (IFNAR2) effective against HCV with EC50 value of 200 nM. RO8191 phosphorylates STAT1 and STAT2, which functions as a gateway to the type I IFN signal cascade, and stimulates the phosphorylation of STAT3, 5 and 6. Synonyms: Ro 494-8191; 2-[2,4-bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole; 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine. Grades: ≥98%. CAS No. 691868-88-9. Molecular formula: C14H5F6N5O. Mole weight: 373.2. | |
| Rocilinostat | Rocilinostat is an orally bioavailable histone deacetylase 6 (HDAC6) inhibitor with potential antineoplastic activity. It selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Compared to non-selective HDAC inhibitor, Rocilinostat is able to reduce the toxic effects on normal, healthy cells. Uses: Antineoplastic agents. Synonyms: ACY-1215; ACY1215; ACY 1215; Rocilinostat; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide. Grades: 98%. CAS No. 1316214-52-4. Molecular formula: C24H27N5O3. Mole weight: 433.512. | |
| (R)-O-Demethylmetoprolol | (R)-O-Demethylmetoprolol is an impurity of Betaxolol, which is a selective beta1 adrenergic receptor blocker for the treatment of hypertension and glaucoma. Synonyms: O-Demethylmetoprolol, (+)-; (R)-(+)-O-Demethylmetoprolol. CAS No. 131564-70-0. Molecular formula: C14H23NO3. Mole weight: 253.342. | |
| (R)-Ofloxacin | An impurity of Ofloxacin, which is a synthetic broad-spectrum antimicrobial agent. Synonyms: (3R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid; (+)-Ofloxacin. Grades: > 95%. CAS No. 100986-86-5. Molecular formula: C18H20FN3O4. Mole weight: 361.38. | |
| Rogaratinib | Rogaratinib is a pan inhibitor of human fibroblast growth factor receptors (FGFRs). It reduced proliferation in FGFR-addicted cancer cell lines of various cancer types including lung, breast, colon and bladder cancer. Synonyms: BAY-1163877; BAY 1163877; BAY1163877. CAS No. 1443530-05-9. Molecular formula: C23H26N6O3S. Mole weight: 466.6. | |
| (R)-Omeprazole Sodium Salt | (R)-Omeprazole Sodium Salt is an impurity of Omeprazole. Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia. It binds to the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) and inhibits its activity and the parietal cell secretion of H+ ions into the gastric lumen. Uses: R-form of omeprazole. gastric proton-pump inhibitor. Synonyms: 5-Methoxy-2-[(R-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium salt; (R)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium salt; (+)-Omeprazole sodium salt. Grades: >95%. CAS No. 161796-77-6. Molecular formula: C17H18N3NaO3S. Mole weight: 367.40. | |
| Romidepsin | Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Uses: For research used only. Synonyms: Istodax; FK228; FK 228; FK-228; Chromadax; Antibiotic FR 901228; FR901228; FR-901228; NSC-630176; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide. Grades: >98%. CAS No. 128517-07-7. Molecular formula: C24H36N4O6S2. Mole weight: 540.69. | |
| Ronomilast | Ronomilast is type 4 cyclic nucleotide phosphodiesterase inhibitor for the treatment of chronic obstructive pulmonary disease (COPD). Uses: Type 4 cyclic nucleotide phosphodiesterase inhibitor. Synonyms: AWD 12353; AWD12353; AWD-12353; ELB353; ELB-353; ELB 353; Elbimilast; Ronomilast.N-(3,5-dichloropyridin-4-yl)-2-(1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetamide. Grades: ≥98%. CAS No. 418794-42-0. Molecular formula: C21H13Cl2FN4O2. Mole weight: 443.25. | |
| Ropidoxuridine | Ropidoxuridine is a novel, orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR). It has radiosensitizing activity. It is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. It is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. It is associated with a lower toxicity profile and improved anti-tumor activity. It has dose responsive and synergistic effects. It has also shown reduced toxicity, with better tissue incorporation and improved anti-tumor activity. It maybe used to treat colorectal, gastric, and pancreatic cancer, and other solid tumors. Uses: Ropidoxuridine has radiosensitizing activity. it maybe used to treat colorectal, gastric, and pancreatic cancer, and other solid tumors. Synonyms: IPdR; D08992; Ropidoxuridine; 5-Iodo-2-pyrimidinone-2-deoxyribose. 1-(2-deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone;5-Iodo-2-pyrimidinone-2'-deoxyribose;IPdR;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one. Grades: >98 %. CAS No. 93265-81-7. Molecular formula: C9H11IN2O4. Mole weight: 338.10. | |
| Roquinimex | Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. Check for active clinical trials or closed clinical trials using this agent. Synonyms: FCF89; FCF-89; FCF 89; LS2616; LS-2616; LS 2616; Quinoline-3-carboxamide; CCRIS 7673; Linomide. Grades: >98%. CAS No. 84088-42-6. Molecular formula: C18H16N2O3. Mole weight: 308.33. | |
| Rosarin | Rosarin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. It exhibits anti-inflammatory and neuroprotective effects. Synonyms: (2E)-3-Phenylprop-2-en-1-yl 6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranoside. Grades: >98%. CAS No. 84954-93-8. Molecular formula: C20H28O10. Mole weight: 428.4. | |
| Rosavin | Rosavin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. It exhibits antidepressant and anxiolytic activity. Uses: Antidepressant and anxiolytic. Synonyms: [(E)-3-Phenyl-2-propenyl]6-O-(α-L-arabinopyranosyl)-β-D-glucopyranoside; [(E)-3-Phenyl-2-propenyl]6-O-α-L-arabinopyranosyl-β-D-glucopyranoside; (2E)-3-phenyl-2-propenyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside; (2S,3R,4S,5S,6R)-2-[(E)-3-phenylprop-2-enoxy]-6-([(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxyMethyl)oxane-3,4,5-triole; Rosavidin; (2R,3R,4S,5S,6R)-2-(cinnamyloxy)-6-((((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)Methyl)tetrahydro-2H-pyran-3,4,5-triol; b-D-Glucopyranoside, (2E)-3-phenyl-2-propen-1-yl 6-O-a-L-arabinopyranosyl-. Grades: >98%. CAS No. 84954-92-7. Molecular formula: C20H28O10. Mole weight: 428.43. | |
| Rosmanol | Rosmanol is a novel antioxidant found in Rosemary. Synonyms: UNII-F25TV383OC; (4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one; AK101906; SCHEMBL459610. CAS No. 80225-53-2. Molecular formula: C20H26O5. Mole weight: 346.423. | |
| Rosoxacin | Rosoxacin. Rosoxacin is a 4-quinolone antibacterial with actions similar to those of nalidixic acid have antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. Uses: Quinolone antibiotic. Synonyms: 1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid; PD-107522;Win-35213. Grades: ≥98%. CAS No. 40034-42-2. Molecular formula: C17H14N2O3. Mole weight: 294.31. | |
| Rosuvastatin EP Impurity A | Rosuvastatin EP Impurity A is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Synonyms: (3R,5S,6E)-7-[2-(2,N-Dimethyl-2-hydroxypropane-1-sulfonamido)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl](methyl)amino]-6-(1-methylethyl)-pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,E)-7-(4-(4-Fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid; S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl]methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl]methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid; Rosuvastatin Calcium EP Impurity A. Grades: ≥95%. CAS No. 1715120-13-0. Molecular formula: C25H34FN3O7S. Mole weight: 539.62. | |
| Rosuvastatin EP Impurity C Sodium Salt | Rosuvastatin EP Impurity C Sodium Salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Synonyms: Rosuvastatin Impurity Sodium Salt; 5-Oxo Rosuvastatin Sodium Salt; Sodium (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate; (3R, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3-hydroxy-5-oxo-6-heptenoic Acid Sodium Salt; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, sodium salt (1:1), (3R,6E)-; (3R, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3-hydroxy-5-oxo-6-heptenoic acid sodium salt. Grades: ≥95%. CAS No. 1620823-61-1. Molecular formula: C22H25FN3NaO6S. Mole weight: 501.51. | |
| Rosuvastatin Impurity 12 | An impurity of Rosuvastatin. Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Synonyms: SCHEMBL1021914; SCHEMBL1022804; 2-((4R,6S)-6-((E)-2-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid; 894787-93-0. Grades: 95%. CAS No. 894787-93-0. Molecular formula: C25H32FN3O6S. Mole weight: 521.60. | |
| Rosuvastatin Impurity C | Cas No. 1422619-13-3. | |
| Rosuvastatin lactone | Cas No. 503610-43-3. | |
| Rosuvastatin Z-Isomer Calcium Salt | Rosuvastatin Z-Isomer Calcium Salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Synonyms: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6Z)-; Calcium (3R,5S,Z)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate; (3R,5S,6Z)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid calcium salt. Grades: ≥95%. CAS No. 1444772-08-0. Molecular formula: C22H27FN3O6S.1/2Ca. Mole weight: 500.57. | |
| Rotundatin | Rotundatin is a 9,10-dihydrophenanthrene derivative isolated from the orchid, Dendrobium rotundatum. Synonyms: 2,5,9-Trihydroxy-4-methoxy-9,10-dihydrophenanthrene. Grades: >98%. CAS No. 144506-16-1. Molecular formula: C15H14O4. Mole weight: 258.27. | |
| RP 001 hydrochloride | Cas No. 1306761-53-4. | |
| Rp-8-bromo-Cyclic AMPS sodium salt | Rp-8-bromo-Cyclic AMPS is a cell-permeable cAMP analog and an antagonist of cAMP-dependent protein kinases (PKAs). Synonyms: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer; Rp-8-Br-cAMPS; Rp-8-bromo-cAMPS. Grades: ≥98%. CAS No. 925456-59-3. Molecular formula: C10H10BrN5O5PS·Na. Mole weight: 446.1. | |
| Rp-8-bromo-Cyclic GMPS sodium salt | Rp-8-bromo-Cyclic GMPS is a cell-permeable analog of cGMP and an inhibitor of cGMP-dependent protein kinase (cGK). Synonyms: 8-bromo-guanosinecyclic3',5'-[(R)-(hydrogenphosphorothioate)], monosodium salt; Rp-8-Br-cGMPS; Rp-8-bromo-cGMPS. Grades: ≥99%. CAS No. 208445-06-1. Molecular formula: C10H10BrN5O6PS·Na. Mole weight: 462.1. | |
| Rp-8-bromo-PET-Cyclic GMPS sodium salt | Rp-8-bromo-PET-Cyclic GMPS is an analog of cyclic GMP (cGMP) and an inhibitor of cGMP-dependent protein kinases (cGKs). Synonyms: Rp-8-Br-PET-cGMPS; Rp-8-bromo-PET-cGMPS. Grades: ≥99%. CAS No. 185246-32-6. Molecular formula: C18H14BrN5O6PS·Na. Mole weight: 562.27. | |
| Rp-8-CPT-Cyclic AMP sodium salt | Rp-8-CPT-cAMP is a combination of lipophilic and hydrolizable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS. It also acts as a site-selective inhibitor of protein kinase A (PKA) type I and II. Synonyms: Rp-8-CPT-cAMP. Grades: ≥98%. CAS No. 221905-35-7. Molecular formula: C16H14ClN5O5PS2·Na. Mole weight: 509.8. | |
| Rp-8-pCPT-cGMPS sodium | Rp-8-pCPT-cGMPS sodium, a stable, cell-permeable cGMP analog, is a PKG inhibitor (Ki= 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Synonyms: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium; Rp-8-pCPT-cGMPS. Grades: ≥99% by HPLC. CAS No. 208445-07-2. Molecular formula: C16H14ClN5NaO6PS2. Mole weight: 525.86. | |
| RPI-1 | RPI-1 is a cell-permeable, ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. It can also be used in biological study of proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations and identification of new signaling elements. Synonyms: 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one; RPI-1; RPI1; RPI 1. CAS No. 269730-03-2. Molecular formula: C17H15NO4. Mole weight: 297.31. | |
| (R)-(-)-PK 11195 | (R)-(-)-PK 11195 is the (R)-enantiomer of PK 11195, which is a peripheral benzodiazepine antagonist with high affinity for PBR in all species. It is used as a drug reference standard of [11C](R)-PK 11195 in PET studies. Synonyms: (R)-(-)-PK 11195; (R)-(-)-PK11195; (R)-(-)-PK-11195. Grades: 99%. CAS No. 205934-46-9. Molecular formula: C21H21ClN2O. Mole weight: 352.86. | |
| R-Rivaroxaban | 5-R-Rivaroxaban is the R-isomer of Rivaroxaban, which is a novel, oral, direct Factor Xa (FXa) inhibitor. It is useful for antithrombotic agent and is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic. Uses: 5-r-rivaroxaban is useful for antithrombotic agent and is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic. Synonyms: (R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide;5-Chloro-N-({(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide;BAY 59-7939;R-Rivaroxaban;ent-Rivaroxaban. Grades: >98%. CAS No. 865479-71-6. Molecular formula: C19H18ClN3O5S. Mole weight: 435.88. | |
| RS-1 | RS-1, a cell-permeable sulfonamido-benzamide compound that increases the DNA binding activity of RAD51 (Kd range = 48-107 nM, value depends on cofactors present). Synonyms: RS-1; RS 1; RS1. RAD51-Stimulatory Compound-1. 3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide3-((benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)benzamideRS-1 compound. CAS No. 312756-74-4. Molecular formula: C20H16Br2N2O3S. Mole weight: 524.23. | |
| RS 16566 dihydrochloride | RS 16566 dihydrochloride was found to be a high affinity ligand for the (R)- zacopride binding site (pKi 9.84). Synonyms: RS 16566 dihydrochloride; RS16566 dihydrochloride; RS-16566 dihydrochloride; (R)-N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-1-(1-methylethyl)-1H-benzimidazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 1217788-97-0. Molecular formula: C18H23ClN4O.2HCl. Mole weight: 419.78. | |
| RS 45041-190 hydrochloride | RS 45041-190 hydrochloride is a highly selective I2 imidazoline receptor ligand and its hyperphagic effect may suggest a role for I2 imidazoline receptors in the modulation of appetite. However, in the absence of a selective agonist it is unclear whether this ligand is an agonist or an antagonist at I2 receptors. Synonyms: RS 45041-190 hydrochloride; RS-45041-190 hydrochloride; RS45041190 hydrochloride; 4-Chloro-2-(imidazolin-2-yl)isoindoline hydrochloride; RS-45041-190. CAS No. 204274-74-8. Molecular formula: C11H12ClN3.HCl. Mole weight: 258.15. | |
| (RS)-4-Carboxy-3-hydroxyphenylglycine | (RS)-4-Carboxy-3-hydroxyphenylglycine has been found to be a broad spectrum EAA ligand. Synonyms: (RS)-4C3H-PG. Grades: ≥98% by HPLC. CAS No. 134052-66-7. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
| (RS)-4-Carboxyphenylglycine | (RS)-4-Carboxyphenylglycine has been found to be a broad spectrum EAA ligand. Synonyms: α-Amino-4-carboxybenzeneacetic Acid; (±)-α-Amino-4-carboxy-benzeneacetic Acid. Grades: ≥99% by HPLC. CAS No. 7292-81-1. Molecular formula: C9H9NO4. Mole weight: 195.17. | |
| (R,S)-AMPA | AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Synonyms: α-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid. Grades: ≥99%. CAS No. 77521-29-0. Molecular formula: C7H10N2O4. Mole weight: 186.2. | |
| RSM-932A | RSM-932A is a novel anticancer drug. Its target is the human choline kinase alpha. Choline kinase alpha is an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A can reduce parasitemia and induce the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion. Uses: Anticancer. Synonyms: RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide. Grades: 98%. CAS No. 850807-63-5. Molecular formula: C46H38Br2Cl2N4. Mole weight: 877.55. | |
| (R,S)-Stylopine | Cas No. 4312-32-7. | |
| RTA-408 | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Synonyms: RTA408; RTA408; RTA-408. Omaveloxolone; Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-. Grades: >98%. CAS No. 1474034-05-3. Molecular formula: C33H44F2N2O3. Mole weight: 554.723. | |
| RU-302 | RU-302 is a pan-tam inhibitor that can block the interface between the extracellular domain of TAM Ig1 and the Lg domain of Gas6. It can effectively block the activation of Axl receptors induced by Gas6 and inhibit lung cancer tumor growth. Synonyms: RU 302; RU302. Grades: ≥98% by HPLC. CAS No. 1182129-77-6. Molecular formula: C24H24F3N3O2S. Mole weight: 475.5. | |
| RuBi-Glutamate | RuBi-Glutamate, a ruthenium-bipyridine-trimethylphosphine caged glutamate, can be excited by visible wavelengths and releases glutamate after one- or two- photon excitation. RuBi-Glutamate has a relatively high absorption cross section in the visible (blue) and has a high quantum efficiency of uncaging which allows use at low concentrations. Synonyms: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt. Molecular formula: C28H32N5O4PRu.2NaPF6. Mole weight: 970.54. | |
| RuBi-Nicotine | RuBi-Nicotine is a ruthenium-bisbipyridine-caged nicotine with nanosecond range kinetics and visible light sensitivity. Synonyms: Bis(2,2'-bipyridine-N,N')bis(S-nicotine-N1) ruthenium(2+) dichloride. CAS No. 1256362-30-7. Molecular formula: C40H44Cl2N8Ru. Mole weight: 808.81. | |
| Rubratoxin A | Rubratoxin A is a competitive inhibitor of protein phosphatase 2A (PP2A) with anticancer activity. It hardly inhibits any other phosphatases. Rubratoxin A showed higher suppression of tumor metastasis and reduction of the primary tumor volume than cytostatin in mouse experiments. Synonyms: BRN 1633008; HSDB 3532. Grades: ≥95%. CAS No. 22467-31-8. Molecular formula: C26H32O11. Mole weight: 520.5. | |
| Rubratoxin B | Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver, and has anti-cancer activity. Synonyms: J38U4758MY. Grades: 98%. CAS No. 21794-01-4. Molecular formula: C26H30O11. Mole weight: 518.5. | |
| Rucaparib | Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair. Uses: Cancer therapy. Synonyms: 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one; Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca. Grades: >98%. CAS No. 283173-50-2. Molecular formula: C19H18FN3O. Mole weight: 323.36. | |
| Rucaparib Camsylate | Rucaparib camsylate is a PARP inhibitor. Synonyms: Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:x); 8-fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (1:x); 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1:x). Grades: ≥98% by HPLC. CAS No. 1327258-57-0. Molecular formula: C19H18FN3O.xC10H16O4S. Mole weight: 323.37 (free base). | |
| Rucosopasem Manganese | Rucosopasem manganese is a superoxide dismutase (SOD) mimic. Synonyms: FW5T90VM32; GC-4419 dipropionate; Bis-propionato(gc4419); Avasopasem manganese dipropionate. Grades: >98%. CAS No. 2248030-85-3. Molecular formula: C27H45MnN5O4. Mole weight: 558.6. | |
| Ruscogenin | Ruscogenin is a saponin found in the root of Ophiopogon japonicus. It inhibits the expressions of TF, iNOS, and NF-kappaB p65 and is therefore a potential target for acute lung injury or sepsis. It remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. Synonyms: (25R)-spirost-5-ene-1-beta,3-beta-diol; Ruscorectal; (1β,3β,25R)-Spirost-5-ene-1,3-diol. Grades: >98%. CAS No. 472-11-7. Molecular formula: C27H42O4. Mole weight: 430.6. | |
| Rusfertide | Rusfertide is a mimic of hepcidin. Synonyms: UNII-XM71MYX0IQ; XM71MYX0IQ; PTG-300; S6,S16-cyclo[N-(3-methylbutanoyl)-L-α-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-cysteinyl-L-isoleucyl-N6-(N-hexadecanoyl-L-γ-glutamyl)-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-lysinamide]. CAS No. 1628323-80-7. Molecular formula: C114H181N27O28S. Mole weight: 2441.95. | |
| RUSKI-201 dihydrochloride | RUSKI-201 dihydrochloride is a sonic hedgehog acyltransferase (HHAT) inhibitor (IC50 = 0.20 μM) devoid of off-target cytotoxicity, and quantitative whole-proteome palmitoylation profiling with a bioorthogonal alkyne-palmitate reporter. Synonyms: RUSKI-201 dihydrochloride; RUSKI 201 dihydrochloride; RUSKI201 dihydrochloride; 2-(2-methylbutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone dihydrochloride. Grades: 98%. Molecular formula: C20H27N3OS.2HCl. Mole weight: 430.43. | |
| Ruxolitinib | Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50 values of 3.3 nM and 2.8 nM respectively in cell-free assays, and has > 130-fold selectivity for JAK1/2 versus JAK3. Synonyms: (R)-Ruxolitinib; INCB018424; R-INCB018424; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile. Grades: >98%. CAS No. 941678-49-5. Molecular formula: C17H18N6. Mole weight: 306.37. | |
| RVX297 | RVX297 is a BD2 selective inhibitor of BET bromodomains. It is structurally related to the clinical compound RVX-208. It has significant implications on differential gene expression, which possibly can be further linked to the specific disease indication. It is currently undergoing phase III clinical trials for the treatment of cardiovascular diseases. Uses: Rvx297 is used for the treatment of cardiovascular diseases. Synonyms: RVX-297; RVX 297; RVX297. 2-(3,5-Dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one. Grades: >98 %. CAS No. 1044871-04-6. Molecular formula: C24H29N3O4. Mole weight: 423.51. | |
| (R)-ZINC 3573 | Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM). Displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. Synonyms: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine; N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine; N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine. Grades: ≥98% by HPLC. CAS No. 2089389-15-9. Molecular formula: C18H21N5. Mole weight: 307.4. | |
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