MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dubermatinib | Dubermatinib (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TP-0903. CAS No. 1341200-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12963. |  |
| DUB-IN-2 | DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 ?M for USP8[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 924296-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50737A. | |
| Dulaglutide | Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: LY2189265. CAS No. 923950-08-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0120. | |
| Duligotuzumab | Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody that specifically targets Her3 (ErbB3) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEHD-7945A; RG 7597. CAS No. 1314238-96-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99866. | |
| Duloxetine hydrochloride | Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-Duloxetine hydrochloride; LY-248686 hydrochloride. CAS No. 136434-34-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0161A. | |
| Duocarmycin Analog | Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 372954-15-9. Pack Sizes: 1 mg. Product ID: HY-129355. | |
| Duocarmycin DM free base | Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116745-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128915. | |
| Duocarmycin SA | Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130288-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12456. | |
| DUPA | DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in agent conjugate to selectively deliver cytotoxic agents to prostate cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 302941-52-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111606. | |
| Dupilumab | Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN-668; SAR-231893. CAS No. 1190264-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9926. | |
| Duramycin | Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Moli1901; Lancovutide. CAS No. 1391-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106302. | |
| Durlobactam sodium | Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC 50 s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ETX2514. CAS No. 1467157-21-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117974. | |
| Durvalumab | Durvalumab (MEDI 4736) is an human anti- PD-L1 monoclonal antibody [1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80 , with IC 50 s of 0.1 and 0.04 nM, respectively [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI 4736. CAS No. 1428935-60-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9919. | |
| Durvalumab (anti-PD-L1) | Durvalumab (anti-PD-L1)(MEDI 4736) is a human anti- PD-L1 protein monoclonal antibody. Durvalumab (anti-PD-L1) completely blocks PD-L1 binding to PD-1 and CD80 , IC 50 are 0.1 and 0.04 nM respectively, has anti-tumor activity [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI 4736 (anti-PD-L1). CAS No. 1428935-60-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9919A. | |
| Dusquetide | Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection [1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns. Uses: Scientific research. Group: Peptides. Alternative Names: SGX942. CAS No. 931395-42-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2076. | |
| Dutasteride | Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GG 745; GI 198745. CAS No. 164656-23-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13613. | |
| Dutogliptin | Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 ( DPP4 ) inhibitor for the treatment of type 2 diabetes mellitus. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PHX-1149 free base. CAS No. 852329-66-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10286. | |
| Duvakitug | Duvakitug is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15 /TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2750005-84-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990006. | |
| Duvelisib | Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC 50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI-145; INK1197. CAS No. 1201438-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17044. | |
| Duvortuxizumab | Duvortuxizumab (MGD 011) is a chimeric humanized IG antibody targeting CD19 and CD3E [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MGD 011. CAS No. 1831098-91-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99868. | |
| D-Valine | D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid. Uses: Scientific research. Group: Natural products. CAS No. 640-68-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g; 25 g. Product ID: HY-N0717A. | |
| D-Valinol | (2R)-2-Amino-3-methylbutan-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Peptides. Alternative Names: (R)-2-Amino-3-methyl-butanol. CAS No. 4276-9-9. Pack Sizes: 10 g; 25 g; 50 g; 100 g. Product ID: HY-30167. | |
| D-Val-Leu-Arg-pNA acetate | D-Val-Leu-Arg-pNA (acetate) is the acetate form of D-Pro-Phe-Arg-p-nitroanilide (pNa). D-Pro-Phe-Arg-p-nitroanilide (pNa) is the substrate for kallikrein and can be used to assay the activity of kallikrein [1]. Uses: Scientific research. Group: Peptides. CAS No. 162303-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114150D. | |
| D-Val-Leu-Lys-pNA dihydrochloride | D-Val-Leu-Lys-pNA dihydrochloride (D-VLK-pNA dihydrochloride) is a colorimetric substrate for plasminolytic activity. D-Val-Leu-Lys-pNA dihydrochloride is catalytically bound and hydrolyzed by plasmin to release p-nitroaniline (pNA), which can be detected colorimetrically at 405 nm as a measure of plasminolytic activity [1]. Uses: Scientific research. Group: Peptides. Alternative Names: D-Val-Leu-Lys-p-itoailide dihydrochloride; D-VLK-pNA dihydrochloride; S 2251 dihydrochloride. CAS No. 62354-43-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-131409. | |
| dWIZ-1 | dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD)[1]. Uses: Scientific research. Group: Signaling pathways. Product ID: HY-159098. | |
| DX600 | DX600 is a selective ACE2 specific inhibitor ( K D : 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 478188-26-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2222. | |
| Dxd | Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Exatecan derivative for ADC. CAS No. 1599440-33-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13631D. | |
| Dxd-d5 | Dxd-d5 is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 ?M, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Exatecan-d5 derivative for ADC. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-13631DS. | |
| D-Xylulose | D-xylulose is a precursor of the pentiol D-arabitol. Uses: Scientific research. Group: Natural products. CAS No. 551-84-8. Pack Sizes: 5 mg (0.5 M * 66.6 μL in Water); 10 mg (0.5 M * 133.2 μL in Water). Product ID: HY-W010256. | |
| DY131 | DY131 (GSK 9089) is a potent and selective ERR? and ERR? agonist. DY131displays inactive against ERR?, ER? and ER?[1][2]. DY131 also inhibits Smo signaling[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 9089. CAS No. 95167-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15483. | |
| DY-46-2 | DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC50 value of 0.39 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1105110-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-151136. | |
| Dyclonine hydrochloride | Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC 50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dyclocaine hydrochloride. CAS No. 536-43-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0364A. | |
| Dydrogesterone | Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Uses: Scientific research. Group: Signaling pathways. CAS No. 152-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0257A. | |
| Dymanthine | Dymanthine is an anthelminthic. Dymanthine has the potential for the research of multiple intestinal helmintic infestations [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N,N-Dimethyloctadecan-1-amine. CAS No. 124-28-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-121429. | |
| Dynarrestin | Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2222768-84-3. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-121802. | |
| Dynasore | Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 ?M. Dynasore blocks cell migration. Uses: Scientific research. Group: Signaling pathways. CAS No. 304448-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15304. | |
| Dynole 34-2 | Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 μM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1128165-88-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107545. | |
| Dynorphin A | Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 80448-90-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1333. | |
| Dynorphin A (1-8) | Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC 50 =303 nM) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 75790-53-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P2159. | |
| Dyrk1A-IN-4 | Dyrk1A-IN-4 (compound 48) is a potent and orally active DYRK1A and DYRK2 inhibitor with IC 50 s of 2 nM and 6 nM, respectively. Dyrk1A-IN-4 has anticancer effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2091883-59-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147066. | |
| DYRK1-IN-1 | DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical probe[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2814486-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132308. | |
| DZD1516 | DZD1516 is a potent and selective HER2 inhibitor ( IC 50 =0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387570-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155079. | |
| (E)-10-Hydroxynortriptyline | (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A)[1]. E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-10-OH-NT. CAS No. 47132-16-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-U00050. | |
| E1231 | E1231 is an orally active activator of Sirtuin 1 ( SIRT1 ) ( EC 50 =0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K D =9.61 μM) and deacetylated liver X receptor-alpha ( LXRα ), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE -/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one. CAS No. 1031195-19-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117006. | |
| E1R | E1R is a positive allosteric modulator of sigma-1 receptors ( Sig1R PAM ) with cognition-enhancing activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1301211-78-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116463. | |
| E 2012 | E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870843-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-10016. | |
| E235 | E235 is an expression regulator of activates transcription factor 4 ( ATF4 ). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 891894-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153339. | |
| E260 | E260 is a Fer / FerT kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1241537-79-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112097. | |
| (E)-2-Methyl-2-pentenoic acid | (E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16957-70-3. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-W010533. | |
| (E)-3,4,5-Trimethoxycinnamic acid | (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABA A /BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT 2C and 5-HT 1A receptor, with IC 50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMCA. CAS No. 20329-98-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W050162. | |
| (E)-3,4-Dimethoxycinnamic acid | (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway [1]. Anti-apoptotic effects [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (E)-O-Methylferulic acid. CAS No. 14737-89-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N1778A. | |
| E-3620 | E-3620 is a potent 5-HT 3 receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 151213-86-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19199. | |
| (E)-3',6-Disinapoylsucrose | (E)-3',6-Disinapoylsucrose, the index component of Yuanzhi ( Polygala tenuifolia Willd), possesses potent antioxidant activity and antidepressant effect [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 139891-98-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1414. | |
| E3 ligase Ligand 32 | E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2300099-98-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W382038. | |
| E-4031 | E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113559-13-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15551. | |
| (E)-4-Hydroxytamoxifen | (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-Afimoxifene. CAS No. 174592-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-16950B. | |
| (E)-4-Oxo-2-nonenal | (E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-ONE. CAS No. 103560-62-9. Pack Sizes: 5 mg; 500 μg. Product ID: HY-114524. | |
| (E)-5-O-Cinnamoylquinic acid | (E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 6470-68-4. Pack Sizes: 5 mg. Product ID: HY-N8224A. | |
| E6-272 | E6-272 is an inhibitor for human papillomavirus 16 (HPV 16). E6-272 inhibits the proliferation of HPV-positive cells SiHa and CaSki with GI50 of 32 nM and 62 nM. E6-272 induces apoptosis in cell SiHa and CaSki[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 945142-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163901. | |
| E-64 | E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC 50 of 9 nM for papain. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Proteinase inhibitor E 64. CAS No. 66701-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15282. | |
| E6446 dihydrochloride | E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 ?M), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345675-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12756A. | |
| E7016 | E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GPI 21016. CAS No. 902128-92-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13540. | |
| E7090 | E7090 is an orally available, potent, and selective FGFR inhibitor with IC 50 s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1622204-21-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101466. | |
| E7090 succinate | E7090 succinate is an orally available, selective and potent inhibitor of FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC 50 values of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/2/3/4, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1879965-80-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101466A. | |
| E-7386 | E-7386 is an orally active CBP/beta-catenin modulator. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799824-08-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111386. | |
| E7766 diammonium salt | E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242635-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111999A. | |
| E7820 | E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC 50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ER68203-00. CAS No. 289483-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14571. | |
| EA2 | EA2 is a biological active peptide. (This is a peptide substrate for polypeptide N-acetylgalactosaminyltransferase (polypeptide GalNAc-T).). Uses: Scientific research. Group: Peptides. CAS No. 562082-63-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5473. | |
| EA4 | EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA 2 with a K i value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 389614-94-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131722. | |
| EACC | EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864941-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129111. | |
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