MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Dodecyltrimethylammonium bromide | Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1119-94-4. Pack Sizes: 5 g. Product ID: HY-D0838. |  |
| DODMA | DODMA is a cationic lipid that can be used to prepare lipid nanoparticles. DODMA can be used for drug delivery [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 104162-47-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-112755. | |
| Dofetilide | Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK 68789. CAS No. 115256-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0232. | |
| DOI hydrochloride | DOI hydrochloride is a serotonin 5-HT 2A / 2C receptor agonist with K i values of 0.7 nM, 2.4 nM and 20 nM for h5-HT 2A , h5-HT 2C and h5-HT 2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 42203-78-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103124. | |
| Dolasetron | Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDL-73147. CAS No. 115956-12-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0750. | |
| Dolasetron Mesylate hydrate | Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDL-73147EF hydrate. CAS No. 878143-33-0. Pack Sizes: 100 mg; 200 mg. Product ID: HY-B0750B. | |
| Dolastatin 10 | Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. Uses: Scientific research. Group: Peptides. Alternative Names: DLS 10; NSC 376128. CAS No. 110417-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15580. | |
| Dolutegravir | Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572. CAS No. 1051375-16-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13238. | |
| Dolutegravir sodium | Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC 50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC 50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC 50 =3.6-5.8 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S/GSK1349572 sodium. CAS No. 1051375-19-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13238A. | |
| Domagrozumab | Domagrozumab is an anti- myostatin humanized monoclonal antibody with a K D value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PF-06252616. CAS No. 1629605-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99857. | |
| Domatinostat | Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC 50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4SC-202 free base. CAS No. 910462-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16012A. | |
| Domatinostat tosylate | Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC 50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4SC-202. CAS No. 1186222-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16012. | |
| Domiphen bromide | Domiphen bromide is a chemical antiseptic and a quaternary ammonium compound, used as a cationic surfactant. Uses: Scientific research. Group: Signaling pathways. CAS No. 538-71-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B1467. | |
| Domperidone | Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R33812. CAS No. 57808-66-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0411. | |
| Domperidone monomaleate | Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R33812 monomaleate. CAS No. 83898-65-1. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B0411A. | |
| Domvanalimab | Domvanalimab (AB154) is an anti- TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AB154. CAS No. 2368219-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99858. | |
| Donanemab | Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY3002813. CAS No. 1931944-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99859. | |
| Donanemab (Mouse IgG2a) | Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease. Uses: Scientific research. Group: Inhibitory antibodies. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991045. | |
| Donepezil | Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC 50 s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E2020 free base. CAS No. 120014-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14566. | |
| Donepezil-d5 | Donepezil-d 5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: E2020-d5 free base. CAS No. 1128086-25-8. Pack Sizes: 1 mg. Product ID: HY-14566S1. | |
| Donepezil-d5 hydrochloride | Donepezil-d 5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: E2020-d5. CAS No. 1883548-90-0. Pack Sizes: 1 mg. Product ID: HY-B0034S. | |
| Donepezil Hydrochloride | Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC 50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE [1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E2020. CAS No. 120011-70-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-B0034. | |
| Dooku1 | Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 ?M and 1.5 ?M for 2 ?M Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126010. | |
| Dopal | Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species (ROS) , and triggers aggregation of α-synuclein. Dopal elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 5707-55-1. Pack Sizes: 5 mg (65.72 mM * 500 μL in Methanol); 10 mg (65.72 mM * 1 mL in Methanol). Product ID: HY-121252. | |
| Dopamine | Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body [1]. Dopamine acts through D2 dopamine receptor s to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: ASL279 free base. CAS No. 51-61-6. Pack Sizes: 10 mM * 1 mL; 10 mg. Product ID: HY-B0451. | |
| Dopamine D2 receptor antagonist-1 | Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1055411-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129946. | |
| Dopamine-d3 hydrochloride | Dopamine-d 3 (hydrochloride) is the deuterium labeled Dopamine hydrochloride (ASL279)-[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: ASL279-d3. CAS No. 53587-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0451AS4. | |
| Dopamine-d5 hydrochloride | Dopamine-d 5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2193106-55-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0451AS7. | |
| Dopamine hydrochloride | Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body [1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptor s to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: ASL279. CAS No. 62-31-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0451A. | |
| DOPE | DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine. CAS No. 4004-5-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112005. | |
| Dopexamine hydrochloride | Dopexamine hydrochloride is a β2 adrenergic receptor agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FPL60278AR. CAS No. 86484-91-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00205. | |
| DOPG sodium | DOPG sodium is a naturally occurring anionic phospholipid, containing oleic acid (18:1) inserted at the sn-1 and sn-2 positions. DOPG can form a lipid bilayer in an aqueous solution and is used in the generation of micelles, liposomes, and other artificial membranes. DOPG also exhibits anti-inflammatory properties [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 67254-28-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-141571. | |
| Doramapimod | Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38?=38 nM, for p38?=65 nM, for p38?=200 nM, and for p38?=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIRB 796. CAS No. 285983-48-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10320. | |
| Doramectin | Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 117704-25-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-17035. | |
| Doramectin (Standard) | Doramectin (Standard) is the analytical standard of Doramectin. This product is intended for research and analytical applications. Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 117704-25-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17035R. | |
| Doravirine | Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC 50 s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-1439. CAS No. 1338225-97-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16767. | |
| Doripenem | Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S 4661. CAS No. 148016-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0187. | |
| Doripenem monohydrate | Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S 4661 monohydrate. CAS No. 364622-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0187A. | |
| Dornase alfa | Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions. Dornase alfa plays an important role in cystic fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: rhDNase. CAS No. 143831-71-4. Pack Sizes: 500 μg. Product ID: HY-108858. | |
| D-Ornithine hydrochloride | D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of bacterial cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-Ornithine hydrochloride. CAS No. 16682-12-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-34516. | |
| Dorsomorphin | Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor ( K i =109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2 , ALK3 , and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Compound C; BML-275. CAS No. 866405-64-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13418A. | |
| Dorsomorphin dihydrochloride | Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2 , ALK3 , and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Compound C dihydrochloride; BML-275 dihydrochloride. CAS No. 1219168-18-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13418. | |
| Dorzagliatin | Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HMS5552. CAS No. 1191995-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109030. | |
| Dorzolamide hydrochloride | Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC 50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: L671152 hydrochloride; MK507 hydrochloride. CAS No. 130693-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 100 mg; 250 mg. Product ID: HY-B0109A. | |
| Dosimertinib mesylate | Dosimertinib-d 5 (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d 5 (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d 5 (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d 5 (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC)[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2403760-72-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-142283AS. | |
| DOSPA | DOSPA is a cationicliposome. DOSPA can formulate with DNA to be a transfection system. DOSPA can be used for gene therapy research [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 282533-23-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142997. | |
| Dostarlimab | Dostarlimab (TSR-042) is a humanized anti- PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC 50 s of 1.8 and 1.5 nM, respectively [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TSR-042. CAS No. 2022215-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99345. | |
| Dot1L-IN-4 | Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2565705-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135127. | |
| DOTA-LM3 | DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis[1][2]. DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 1192362-32-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5126. | |
| DOTA-NHS-ester | DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 170908-81-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-128890. DOTA-?NHS-ester | |
| DOTAP chloride | DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane chloride. CAS No. 132172-61-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-112754A. | |
| DOTA-PEG5-azide | DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140752. | |
| DOTA-PEG5-C6-DBCO | DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-140314. | |
| DOTAP mesylate | DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 252769-92-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W127426. | |
| DOTAP methylsulfate | DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate. CAS No. 144189-73-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg. Product ID: HY-W127378. | |
| DOTATATE | DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106244. | |
| DOTATATE acetate | DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106244A. | |
| DOTA-tris(tBu)ester NHS ester | DOTA-tris(tBu)ester NHS ester is a derivative of DOTA for the labeling of peptides and antibodies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 819869-77-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-131326. | |
| DOTA-tri(t-butyl ester) | DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 137076-54-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W034551. | |
| Dothiepin | Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dosulepin; Dothep. CAS No. 113-53-1. Pack Sizes: 1 mg. Product ID: HY-12394. | |
| DOTMA | DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 104872-42-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-139200. | |
| Dotriacontane | Dotriacontane is an alkane substance that can be absorbed and metabolized by photosynthetic organisms. It can be labeled with 14 C and used for carbon tracing [1]. Uses: Scientific research. Group: Natural products. CAS No. 544-85-4. Pack Sizes: 5 g; 10 g. Product ID: HY-N9600. | |
| DOV-216,303 Free Base | DOV-216,303 (Free Base) is a potent triple serotonin , norepinephrine , and dopamine reuptake inhibitor, with IC 50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively [1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66504-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18332C. | |
| Dovitinib | Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC 50 s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , CSF-1R , FGFR1/FGFR3 , VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ , respectively. Dovitinib has potent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258; TKI258. CAS No. 405169-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50905. | |
| Dovitinib lactate | Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , FGFR1/3 , VEGFR1/2/3 and PDGFRα/β , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258 lactate; TKI-258 lactate. CAS No. 692737-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10207. | |
| Dowicil 200 | Dowicil 200 (Quaternium-15) is a skin toxin and allergen that inhibits the growth of Pinctada fucata cells. Dowicil 200 has antimicrobial activity and is more potent against fungi and molds than against fungi. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Quaternium-15. CAS No. 51229-78-8. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-W009497. | |
| Doxapram | Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 309-29-5. Pack Sizes: 10 mg; 25 mg. Product ID: HY-B0551. | |
| Doxapram hydrochloride hydrate | Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 7081-53-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0551A. | |
| Doxazosin | Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Uses: Scientific research. Group: Natural products. Alternative Names: UK 33274. CAS No. 74191-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-B0098. | |
| Doxazosin mesylate | Doxazosin mesylate (UK 33274 mesylate) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UK 33274 mesylate. CAS No. 77883-43-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0098A. | |
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