MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Gramicidin S | Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Gramicidin soviet. CAS No. 113-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5712. |  |
| Gramine | Gramine (Donaxine) is a natural alkaloid isolated from giant reed [2] , acts as an active adiponectin receptor (AdipoR) agonist, with IC 50 s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively [1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist [2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Donaxine. CAS No. 87-52-5. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N0166. | |
| Granisetron | Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 43694. CAS No. 109889-09-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0071. | |
| Granisetron Hydrochloride | Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 43694A. CAS No. 107007-99-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0071A. | |
| Grape seed extract | Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 84929-27-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N7072. | |
| Grapiprant | Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E 2 (PGE 2 ). Grapiprant displaces [ 3 H]-PGE 2 (1 nM) binding to dog recombinant EP4 receptor with IC 50 value of 35 nM and K i value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CJ-023423; RQ-00000007; AAT-007. CAS No. 415903-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16781. | |
| Grazoprevir | Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K i s of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] [2]. Grazoprevir inhibits SARS-CoV-2 3CL pro activity [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-5172. CAS No. 1350514-68-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15298. | |
| Grazoprevir hydrate | Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K i s of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] [2]. Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-5172 hydrate. CAS No. 1350462-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15298B. | |
| Gremubamab | Gremubamab (MEDI3902) is a humanized IgG1 kappa anti- PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI3902. CAS No. 1800381-36-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99649. | |
| Grepafloxacin hydrochloride | Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OPC-17116 hydrochloride; dl-Grepafloxacin hydrochloride. CAS No. 161967-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0147A. | |
| Griseofulvin | Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 126-07-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-17583. | |
| Griseofulvin (Standard) | Griseofulvin (Standard) is the analytical standard of Griseofulvin. This product is intended for research and analytical applications. Uses: Scientific research. Group: Natural products. CAS No. 126-07-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-17583R. | |
| GRK2 Inhibitor 1 | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24269-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123538. | |
| GS39783 | GS39783 is a positive allosteric modulator (PAM) of GABA B R. Positive modulation of the GABA B R can be used for the research of Nicotine addiction [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39069-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103475. | |
| GS-441524 | GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC 50 of 0.78 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191237-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103586. | |
| GS-9667 | GS-9667 (CVT 3619), a novel N 6 -5'-substituted adenosine analog, is a selective, partial agonist of the A 1 adenosine receptor (A 1 AdoR). GS-9667 binds to adipocyte membranes with high (K H =14 nM) and low (K L =5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC 50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CVT 3619. CAS No. 618380-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19842. | |
| GSK1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC 50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 958852-01-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12036. | |
| GSK-1070806 | GSK-1070806 is a CHO-expressed humanized antibody that targets IL-18. GSK-1070806 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 147.38 kDa. The isotype control for GSK-1070806 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Aletekitug. CAS No. 2923284-67-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990591. | |
| GSK1521498 free base | GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and agents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1007573-18-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115066. | |
| GSK 1562590 hydrochloride | GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT) , with pK i s of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1003878-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108446. | |
| GSK1904529A | GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) , with IC 50 s of 27 and 25 nM, respectively. GSK1904529A shows poor activity ( IC 50 >1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1089283-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10524. | |
| GSK2018682 | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC 50 s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis. Uses: Scientific research. Group: Signaling pathways. CAS No. 1034688-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-19511. | |
| GSK2245035 | GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC 50 s of 9.3 and 6.5 for IFNα and TFN&alpha. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1207629-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118250. | |
| GSK2256098 | GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 1224887-10-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100498. | |
| GSK-2256098 hydrochloride | GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416771-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100498A. | |
| GSK239512 | GSK239512 is a potent and brain penetrated H 3 receptor antagonist. GSK239512 can be used for the research of mild-to-moderate Alzheimer's disease (AD) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 720691-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106000. | |
| GSK2578215A | GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC 50 s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. Uses: Scientific research. Group: Signaling pathways. CAS No. 1285515-21-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13237. | |
| GSK2636771 | GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a K i of 0.89 nM and an IC 50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms. Uses: Scientific research. Group: Signaling pathways. CAS No. 1372540-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15245. | |
| GSK2807 Trifluoroacetate | GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3 , with a K i of 14 nM and an IC 50 of 130 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245255-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104009A. | |
| GSK3004774 | GSK3004774 is a potent, nonabsorbable agonist of CaSR , with an pEC 50 of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC 50 of 50 nM for human CaSR [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138814-32-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107773. | |
| GSK 3008348 | GSK 3008348 is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for Integrin Antagonist 1 was 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). Uses: Scientific research. Group: Signaling pathways. CAS No. 1629249-33-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19767. | |
| GSK 3008348 hydrochloride | GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). Uses: Scientific research. Group: Signaling pathways. CAS No. 1629249-40-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19767A. | |
| GSK3117391 | GSK3117391 (ESM-HDAC391) is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ESM-HDAC391; CHR-5154; HDAC-IN-3. CAS No. 1018673-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19772. | |
| GSK3145095 | GSK3145095 is a RIP1 kinase inhibitor with an IC 50 of 6.3 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1622849-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111946. | |
| GSK3326595 | GSK3326595 is a protein arginine methyltransferase 5 ( PRMT5 ) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EPZ015938. CAS No. 1616392-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101563. | |
| GSK3532795 | GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC 50 s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-955176. CAS No. 1392312-45-6. Pack Sizes: 1 mg. Product ID: HY-112714. | |
| GSK-3β inhibitor 11 | GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β ( GSK-3β ) inhibitor ( IC 50 =10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 536731-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148132. | |
| GSK-3β inhibitor 3 | GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) , with an IC 50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448990-73-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141480. | |
| GSK3β inhibitor II | GSK3β inhibitor II is an inhibitor of GSK3&beta. GSK3β inhibitor II can be used for research of Alzheimers disease (AD) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 478482-75-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14679. | |
| GSK-3 inhibitor 3 | GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3 , with IC 50 s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimers disease model, with IC 50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2227279-84-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-154851. | |
| (-)-GSK598809 hydrochloride | (-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1S,5R)-GSK598809 hydrochloride. CAS No. 863766-31-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19654C. | |
| GSK 650394 | GSK 650394 is a novel SGK inhibitor with IC 50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication. Uses: Scientific research. Group: Signaling pathways. CAS No. 890842-28-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15192. | |
| GSK963 | GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase , with an IC 50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2049868-46-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103028A. | |
| GSK-J1 | GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A , with IC 50 of 60 nM towards KDM6B. Uses: Scientific research. Group: Signaling pathways. CAS No. 1373422-53-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15648. | |
| GSK-J2 | GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394854-52-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15648A. | |
| GSK-J4 | GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC 50 s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC 50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 [1] [2] [3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1373423-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15648B. | |
| GSK-J4 hydrochloride | GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC 50 s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC 50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1797983-09-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15648F. | |
| GsMTx4 | GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology [1] [2] [4]. Uses: Scientific research. Group: Peptides. CAS No. 1209500-46-8. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1410. | |
| GTS-21 dihydrochloride | GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti - inflammatory and cognition - enhancing activities. GTS-21 dihydrochloride is also a α4β2 ( K i =20 nM for humanα4β2) and 5-HT3A receptor ( IC 50 =3.1 μM) antagonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DMXB-A; DMBX-anabaseine. CAS No. 156223-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14564A. | |
| GTX-758 | GTX-758 is an orally active, nonsteroidal, selective agonist of ER&alpha. GTX-758 plays an important role in castration resistant prostate cancer (CRPC) research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 938067-78-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-111061. | |
| Guacetisal | Guacetisal is obtained from the esterification of acetylsalicylic acid with guaiacol which has the potential for chronic bronchitis treatment extracted from patent CN 106866420 A. Uses: Scientific research. Group: Signaling pathways. CAS No. 55482-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17477. | |
| Guadecitabine sodium | Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases ( DNMT ) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SGI-110 sodium; S-110 sodium. CAS No. 929904-85-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15229. | |
| Guaiacin | Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-08-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2247. | |
| Guaiacol | Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation [1]. Anti-inflammatory activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methoxyphenol. CAS No. 90-05-1. Pack Sizes: 10 mM * 1 mL; 5 g; 25 g; 50 g. Product ID: HY-N1380. | |
| Guaiacol Carbonate | Guaiacol Carbonate acts as an expectorant by virtue of a reflex from the stomach by way of the afferent gastric nerves to the medullary centres and thenperipherally again to the respiratory tract [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 553-17-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-Y1876. | |
| Guaiazulene | Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 489-84-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N6951. | |
| Guaifenesin | Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate. CAS No. 93-14-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0264. | |
| Guaifenesin (Standard) | Guaifenesin (Standard) is the analytical standard of Guaifenesin. This product is intended for research and analytical applications. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Guaiacol glyceryl ether(Standard); Guaiphenesin(Standard); Glycerol guaiacolate (Standard). CAS No. 93-14-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0264R. | |
| Guaiol | Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC 50 of 0.01 μg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Champacol; Guaiac alcohol. CAS No. 489-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N3980. | |
| Guanabenz Acetate | Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BR-750; Wy8678 acetate. CAS No. 23256-50-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0566. | |
| Guanabenz hydrochloride | Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23113-43-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-12724A. | |
| Guanadrel | Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40580-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W376701. | |
| Guancydine | Guancydine (Guancidine) is an antihypertensive agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guancidine. CAS No. 1113-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-101554. | |
| Guanethidine sulfate | Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanethidine monosulfate. CAS No. 645-43-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0800. | |
| Guanfacine | Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 29110-47-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17416A. | |
| Guanfacine hydrochloride | Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 29110-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17416. | |
| Guanidine hydrochloride | Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Guanidinium chloride; Aminoformamidine hydrochloride. CAS No. 50-01-1. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-B0178A. | |
| Guanidine thiocyanate | Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction [1]. Uses: Scientific research. Group: Natural products. CAS No. 593-84-0. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-D0841. | |
| Guanidinosuccinic acid | Guanidinosuccinic acid is a nitrogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 6133-30-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-113373. | |
| Guanine | Guanine is one of the fundamental components of nucleic acids ( DNA and RNA ). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 73-40-5. Pack Sizes: 100 mg. Product ID: HY-Y1055. | |
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