MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Icariin | Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC 50 s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Uses: Scientific research. Group: Natural products. Alternative Names: Ieariline. CAS No. 489-32-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-N0014. |  |
| Icaritin | Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornu Maxim. and potently inhibits proliferation of K562 cells ( IC 50 of 8 μM) and primary CML cells ( IC 50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis [1] [2] [3. Uses: Scientific research. Group: Natural products. Alternative Names: Anhydroicaritin. CAS No. 118525-40-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0678. | |
| Icatibant | Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC 50 and K i of 1.07 nM and 0.798 nM respectively [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: HOE 140. CAS No. 130308-48-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-17446. | |
| Icatibant acetate | Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC 50 and K i of 1.07 nM and 0.798 nM respectively [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: HOE 140 acetate. CAS No. 138614-30-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108896. | |
| Icenticaftor | Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC 50 s of 79 nM and 497 nM for F508del and G551D CFTR , respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: QBW251. CAS No. 1334546-77-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109177. | |
| ICG-001 | ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC 50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 780757-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14428. | |
| ICI 174864 | ICI 174864 is a highly selective, potent δ-receptor antagonist. ICI 174864 is equipotent with naloxone and can not reverse the effect of the μ-agonist [D-Ala2, MePhe4, Gly-Ol5]enkephalin or the κ-agonist-tifluadom [1]. Uses: Scientific research. Group: Peptides. CAS No. 89352-67-0. Pack Sizes: 1 mg. Product ID: HY-101230. | |
| ICI 199441 | ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 115199-84-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101205. | |
| ICI-204448 | ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121264-04-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101231. | |
| ICI 216140 | ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC 50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124001-41-8. Pack Sizes: 1 mg. Product ID: HY-P3112. | |
| ICI-63197 | ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with K i values of 9 μM and 10 μM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 27277-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103024. | |
| Icilin | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 ( TRPM8 ) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner ( EC 50 =1.4 μM). Icilin is a "super-cooling agent" [1] [2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-3-5. CAS No. 36945-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-11062. | |
| Iclaprim | Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus ( MRSA ) with an MIC 90 of 0.06 μg/mL. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AR-100. CAS No. 192314-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101479. | |
| Iclepertin | Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-425809. CAS No. 1421936-85-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138935. | |
| Icomidocholic acid | Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aramchol; C20-FABAC. CAS No. 246529-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19796. | |
| Icosabutate | Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis [1]. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253909-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121212. | |
| Icotinib | Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009. CAS No. 610798-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164A. | |
| Icotinib Hydrochloride | Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009H. CAS No. 1204313-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164. | |
| ICRF-193 | ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21416-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118590. | |
| ID-8 | ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147591-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15838. | |
| Idalopirdine hydrochloride | Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lu AE58054 hydrochloride. CAS No. 467458-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14338A. | |
| Idarubicin hydrochloride | Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Demethoxydaunorubicin hydrochloride. CAS No. 57852-57-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17381. | |
| Idasanutlin | Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC 50 of 6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG7388. CAS No. 1229705-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15676. | |
| Idazoxan hydrochloride | Idazoxan hydrochloride (RX 781094 hydrochloride) is an α 2 -adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinsons disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RX 781094 hydrochloride. CAS No. 79944-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-14561A. | |
| IDE 2 | IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1136466-93-7. Pack Sizes: 1 mg. Product ID: HY-100534. | |
| Idebenone | Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC 50 =16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells [2]. Idebenone quickly crosses the blood-brain barrier. Uses: Scientific research. Group: Signaling pathways. CAS No. 58186-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0303. | |
| Idelalisib | Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC 50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAL-101; GS-1101. CAS No. 870281-82-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13026. | |
| IDO1-IN-19 | IDO1-IN-19 (Compound 17) is an orally active IDO1 inhibitor with an IC 50 of CYP2C9 of 8.64 μM. IDO1-IN-19 also acts funciton on cardiac channels, with IC 50 s of 12 μM ( IKr ), 40 μM ( INa ), 8.3 μM ( ICa ), respectively. IDO1-IN-19 has the potential to study cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2328099-11-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144652. | |
| IDO-IN-12 | IDO-IN-12 is an indoleamine 2,3-dioxygenase ( IDO ) inhibitor extracted from patent WO 2017181849 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1888341-29-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115122. | |
| Idoxifene | Idoxifene (CB7432) is a novel tissue-specific selective estrogen receptor modulator ( SERM ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB7432. CAS No. 116057-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00178. | |
| Idoxuridine | Idoxuridine (5-Iodo-2-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC 50 value of 4.3 μM [1]. Idoxuridine shows anti-orthopoxvirus activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Iodo-2-deoxyuridine; 5-IUdR; IdUrd. CAS No. 54-42-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0307. | |
| IDR-1 | IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 940291-10-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2320. | |
| IDR 1002 | IDR-1002 is an anti-infective peptide that enhances the ability of human monocytes to migrate toward chemokines on fibronectin. IDR-1002 also induces adhesion and activation of β1-integrin, a mechanism that promotes monocyte recruitment [1]. Uses: Scientific research. Group: Peptides. CAS No. 1224095-25-3. Pack Sizes: 1 mg. Product ID: HY-P5812. | |
| IDRA 21 | IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22503-72-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-101528. | |
| IDX184 | IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase ( IC 50 =0.31 μM, K i =52.3 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1036915-08-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19558. | |
| IEM-1460 | IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121034-89-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103230. | |
| Ieramilimab | Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3 , resulting in inhibition of LAG-3 interaction with MHC-II molecules [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LAG525; IMP701. CAS No. 2137049-37-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99027. | |
| Ifebemtinib | Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase ( FAK ) inhibitor (recombinant FAK IC 50 =1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC 50 s of 900 nM and 1040 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-853520; IN-10018. CAS No. 1227948-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122844. | |
| Ifenprodil tartrate | Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors ( IC 50 =0.34 μM) over 400-fold than at NR1A/NR2A receptors ( IC 50 =146 μM) [1]. Ifenprodil tartrate inhibits GIRK (Kir3) , reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator [2]. Uses: Scientific research. Group: Natural products. CAS No. 23210-58-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-12882A. | |
| Iferanserin | Iferanserin (S-MPEC) is a selective 5-HT receptor ( serotonin receptor ) antagonist with an affinity for 5-HT 2A receptor. Iferanserin has the potential for internal hemorrhoid disease treatment [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-MPEC. CAS No. 58754-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118557. | |
| Ifetroban | Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291. CAS No. 143443-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218. | |
| Ifetroban sodium | Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291 sodium. CAS No. 156715-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218A. | |
| Ifinatamab | Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2484870-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99367. | |
| Ifinatamab deruxtecan | Ifinatamab deruxtecan (DS-7300a) is an ADC that binds an anti-B7-H3 antibody to the DNA topoisomerase I inhibitory anti-tumor drug DXd. Ifinatamab deruxtecan has antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: DS-7300a; MABX-9001a. CAS No. 2484870-92-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3371. | |
| IFN-γ Antagonist 1 | IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ ( IFN γ ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC 50 value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation [1]. Uses: Scientific research. Group: Peptides. CAS No. 158040-83-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4717. | |
| Ifosfamide | Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Uses: Scientific research. Group: Signaling pathways. CAS No. 3778-73-2. Pack Sizes: 200 mg; 500 mg. Product ID: HY-17419. | |
| IgdE protease | IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1892548-76-3. Pack Sizes: 1 KU. Product ID: HY-E70364. | |
| Iguratimod | Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2 , with an IC 50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor ( MIF ) with an IC 50 of 6.81 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T614. CAS No. 123663-49-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17009. | |
| IHR-1 | IHR-1 is a cell membrane impermeable Smo antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 548779-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110240. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC 50 value of <0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153585. | |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| IKKβ-IN-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127. | |
| IL-17-IN-2 | IL-17-IN-2 (Example 51) is a potent inhibitor of IL-17 , with the IC 50 of < 0.4 μM in HTRF and NHK assay [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058278-46-6. Pack Sizes: 1 mg. Product ID: HY-168582. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149. CAS No. 172152-36-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101664. | |
| Ilaprazole sodium | Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149 sodium. CAS No. 172152-50-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2145. | |
| Ilaprazole sodium hydrate | Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149 sodium hydrate. CAS No. 2322264-11-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2145A. | |
| Ilimaquinone | Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus [1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects [2]. Uses: Scientific research. Group: Natural products. CAS No. 71678-03-0. Pack Sizes: 100 μg. Product ID: HY-119500. | |
| Iloperidone | Iloperidone (HP 873) is a D 2 /5-HT 2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HP 873. CAS No. 133454-47-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17410. | |
| Iloprost | Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Ciloprost; ZK 36374. CAS No. 78919-13-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0096. | |
| Ilorasertib | Ilorasertib (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC 50 s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib also is a potent VEGF , PDGF inhibitor. Ilorasertib has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-348. CAS No. 1227939-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16018. | |
| Ilorasertib hydrochloride | Ilorasertib (ABT-348) hydrochloride is a potent, orally active and ATP-competitive aurora inhibitor with IC 50 s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF , PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-348 hydrochloride. CAS No. 1847485-91-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16018A. | |
| Ilunocitinib | Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY-3411067. CAS No. 1187594-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132819. | |
| IM-2 | IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2813269-89-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160157. | |
| IM-250 | IM-250 is an orally active helicase-primase inhibitor. IM-250 is effective against HSV infection. IM-250 inhibits HSV-1 infection in Vero cells (IC 50 : ~20 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305750-23-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150306. | |
| IMAB027 | IMAB027 (ASP1650) is a specific anti- CLDN6 mAb, while CLDN6 ( Claudin 6 ) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 + ovarian and testicular cancer cell lines [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ASP1650. CAS No. 1650599-68-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99413. | |
| Imaradenant | AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor ( A2AR ) antagonist. AZD4635 binds to human A2AR with a K i of 1.7 nM and shows >30-fold selectivity over other adenosine receptors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HTL1071; AZD4635. CAS No. 1321514-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101980. | |
| Imatinib | Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL , v-Abl , PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively [1] [2] [3] [4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI571; CGP-57148B. CAS No. 152459-95-5. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-15463. | |
| Imatinib Mesylate | Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit , Bcr-Abl , and PDGFR ( IC 50 =100 nM) tyrosine kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI571 Mesylate; CGP-57148B Mesylate. CAS No. 220127-57-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-50946. | |
| Imazalil | Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Enilconazole. CAS No. 35554-44-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1134. | |
| Imazamox | Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CL29926; (±)-Imazamox. CAS No. 114311-32-9. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-100427. | |
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