MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Peptidase, microorganism | Peptidase (IMPa) (Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Erepsin; Peptidase (IMPa). CAS No. 9031-96-3. Pack Sizes: 5 g. Product ID: HY-E70017. |  |
| Peptide T | Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor. Uses: Scientific research. Group: Peptides. CAS No. 106362-32-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0272. | |
| Peptide YY (PYY) (3-36), Human | Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion [1]. Uses: Scientific research. Group: Peptides. CAS No. 123583-37-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10000. | |
| Peptide YY (PYY), human | Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors. Uses: Scientific research. Group: Peptides. CAS No. 118997-30-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1514. | |
| Peptone from casein | Peptone from casein is derived from casein hydrolysis, casein is hydrolyzed by pancreatic enzymes and refined into peptone. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 91079-40-2. Pack Sizes: 50 g; 100 g. Product ID: HY-150278. | |
| Peptone from soya | Peptone from soya (Peptones, soybean) is a peptone that is commonly used as a component of culture medium. Peptone from soya can be used in microbiology and cell culture to provide needed sources of nitrogen, carbon and other nutrients. Peptone from soya stimulates/regulates cyclic arachidonic acid biosynthesis. Peptone from soya also exerts enteric cell activity in jejunum of piglets through this mechanism [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Peptones, soybean. CAS No. 91079-46-8. Pack Sizes: 25 g; 100 g. Product ID: HY-W133891. | |
| Peramivir | Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RWJ-270201; BCX-1812. CAS No. 330600-85-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17015A. | |
| Peramivir trihydrate | Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC 50 values ranging from 0.9 to 4.3 nM for nine NA subtypes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RWJ 270201 trihydrate; BCX 1812 trihydrate. CAS No. 1041434-82-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17015. | |
| Peresolimab | Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY-3462817. CAS No. 2411580-63-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9993. | |
| Peretinoin | Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 [1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC 50 of 9 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIK333. CAS No. 81485-25-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100008. | |
| Perfluorodecyl bromide | Perfluorodecyl bromide (PFDB), a Perflubron (PFOB, HY-B1724) analogue, is a high molecular weight lipophilic fluorocarbon. Perfluorodecyl bromide can be used to prepare phospholipid-stabilized fluorocarbon emulsions [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PFDB. CAS No. 307-43-7. Pack Sizes: 50 mg; 100 mg. Product ID: HY-119554. | |
| Pergolide mesylate | Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D 1 and D 2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pergolide methanesulfonate; LY127809. CAS No. 66104-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13720A. | |
| Perhexiline maleate | Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina [1] [2] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6724-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1334A. | |
| Pericyazine | Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis [1]. Pericyazine is a selective D2-dopamine receptor antagonist [2] [3]. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Propericiazine; RP 8909. CAS No. 2622-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14263. | |
| Perifosine | Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC 50 s of 0.6-8.9 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KRX-0401; NSC 639966; D21266. CAS No. 157716-52-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50909. | |
| Perillartine | Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Perillartine. CAS No. 30950-27-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-N2084. | |
| Perillyl alcohol | Perillyl alcohol, a monoterpene, is active in inducing apoptosis in tumor cells without affecting normal cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 536-59-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N7000. | |
| Perindopril | Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: S-9490. CAS No. 82834-16-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B0130. | |
| Perindopril erbumine | Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Perindopril tert-butylamine salt; S-9490 erbumine. CAS No. 107133-36-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B0130A. | |
| Periplogenin | Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 514-39-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2414. | |
| Perisesaccharide B | Perisesaccharide B is an oligosaccharide isolated from the root barks of Periploca sepium. Uses: Scientific research. Group: Natural products. CAS No. 1095261-93-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4249. | |
| Perisesaccharide C | Perisesaccharide C is an oligosaccharide isolated from the root barks of Periploca sepium. Uses: Scientific research. Group: Natural products. CAS No. 1311473-28-5. Pack Sizes: 1 mg. Product ID: HY-N4248. | |
| Permethrin | Permethrin (NRDC-143) is an insecticide , acaricide and a high selectively inhibitor of the Mitochondrial complex I , found in sediment and water samples. Permethrin shows estrogenic in vivo and anti- estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka ( Oryzias latipes ) [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NRDC-143. CAS No. 52645-53-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0887. | |
| Perospirone | Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT 2A receptor ( K i =0.6 nM) and dopamine D 2 receptor ( K i =1.4 nM), and also a partial agonist of 5-HT 1A receptor ( K i =2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-9018 free base. CAS No. 150915-41-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0731A. | |
| Perospirone hydrochloride | Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT 2A receptor ( K i of 0.6 nM) and dopamine D 2 receptor ( K i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT 1A receptor ( K i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-9018. CAS No. 129273-38-7. Pack Sizes: 10 mg; 25 mg. Product ID: HY-B0731. | |
| Peroxidase, Horseradish | Peroxidase, Horseradish actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9003-99-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-125859. | |
| Peroxynitrite sodium | Peroxynitrite sodium is a highly reactive nitroxide species that can decompose at physiological pH [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14042-01-4. Pack Sizes: 25.5 mg (0.3 M * 1 mL in Sodium hydroxide). Product ID: HY-155386. | |
| Perphenazine | Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation [1] [3] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 58-39-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-A0077. | |
| Pertussis Toxin | Pertussis Toxin is a protein-based AB 5 -type exotoxin produced by the bacterium Bordetella pertussis , which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70323-44-3. Pack Sizes: 50 μg. Product ID: HY-112779. | |
| Pertuzumab | Pertuzumab, a humanized IgG1 monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 380610-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9912. | |
| Pertuzumab (anti-HER2) | Pertuzumab (anti-HER2), a humanized monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 380610-27-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9912A. | |
| Peruvoside | Peruvoside is a potent inhibitor of Src , PI3K , JNK , STAT , and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Encordin. CAS No. 1182-87-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108016. | |
| Perylene | Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Peri-dinaphthalene (purified by sublimation); Perylene. CAS No. 198-55-0. Pack Sizes: 1 g; 5 g. Product ID: HY-W090294. | |
| Perzinfotel | Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EAA-090. CAS No. 144912-63-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19168. | |
| Petosemtamab | Petosemtamab (MCLA 158) is an anti- EGFR ( K d : 0.22 nM) and anti- LGR5 ( K d : 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MCLA 158. CAS No. 2213450-26-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99406. | |
| Petroselinic acid | Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid is used as substrate for sophorolipid fermentation [1]. Uses: Scientific research. Group: Natural products. CAS No. 593-39-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113362. | |
| Petunidin-3-O-glucoside chloride | Petunidin-3-O-glucoside chloride is a flavonoid isolated from Phaseolus vulgaris L. seed, has antioxidant activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 6988-81-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N7832. | |
| Petunidin chloride | Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis. Uses: Scientific research. Group: Natural products. CAS No. 1429-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126410. | |
| Pevonedistat | Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme ( NAE ) inhibitor with an IC 50 of 4.7 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN4924. CAS No. 905579-51-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-70062. | |
| Pevonedistat hydrochloride | Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC 50 of 4.7 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN4924 hydrochloride. CAS No. 1160295-21-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10484. | |
| Pexacerfont | Pexacerfont is a selective corticotropin-releasing factor ( CRF 1 ) receptor antagonist with IC 50 of 6.1±0.6 nM for human CRF 1 receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-562086. CAS No. 459856-18-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12127. | |
| Pexidartinib | Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC 50 s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLX-3397. CAS No. 1029044-16-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 20 g. Product ID: HY-16749. | |
| Pexidartinib hydrochloride | Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC 50 s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLX-3397 hydrochloride. CAS No. 2040295-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 20 g. Product ID: HY-16749A. | |
| Pexiganan | Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections [1]. Uses: Scientific research. Group: Peptides. Alternative Names: MSI 78 free base. CAS No. 147664-63-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105088. | |
| PF-00356231 hydrochloride | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 ( IC 50 =1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC 50 s of 0.00065, 1.7, 0.98, 0.39 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 820223-77-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114091. | |
| PF-03463275 | PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a K i of 11.6 nM. PF-03463275 has the potential for Schizophrenia research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173239-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10716A. | |
| PF-03654746 Tosylate | PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms [1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD) [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1039399-17-1. Pack Sizes: 1 mg. Product ID: HY-11044. | |
| PF 03716556 | PF 03716556 is a potent, selective, competitive and reversible acid pump (H + ,K + -ATPase) antagonist with pIC 50 s of 6.026, 6.038 and 6.009 for porcine , canine , and human recombinant gastric H + ,K + -ATPase , respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 928774-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13100. | |
| PF-03732010 | PF-03732010 is a humanized antibody expressed in CHO, targeting CDH3/P-cadherin. PF-03732010 has a huIgG1 type heavy chain and a huλ type light chain, with a predicted molecular weight (MW) of 142.7 kDa. The isotype control for PF-03732010 can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2070913-84-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990645. | |
| PF-04217903 | PF-04217903 is a potent ATP-competitive c-Met kinase inhibitor with K i of 4.8 nM for human c-Met. PF-04217903 shows more than 1,000-fold selectivity relative to 208 kinases. Antiangiogenic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956905-27-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12017. | |
| PF-04217903 mesylate | PF-04217903 mesylate is a potent ATP-competitive c-Met kinase inhibitor with K i of 4.8 nM for human c-Met. PF-04217903 mesylate shows more than 1,000-fold selectivity relative to 208 kinases. Antiangiogenic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956906-93-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12017A. | |
| PF-04418948 | PF-04418948 is an orally active, potent and selective prostaglandin EP 2 receptor antagonist with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1078166-57-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-18966. | |
| PF-04449613 | PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM[1]. PF-04449613 improved motor learning ability in a mouse model[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1236858-52-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12788. | |
| PF-04620110 | PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC 50 of 19 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1109276-89-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13009. | |
| PF-04691502 | PF-04691502 is a potent and selective inhibitor of PI3K and mTOR. PF-04691502 binds to human PI3Kα, β, δ, γ and mTOR with K i s of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1013101-36-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15177. | |
| PF-04859989 hydrochloride | PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC 50 s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 177943-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116451. | |
| PF 05089771 | PF 05089771 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor, with IC 50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNa v 1.7, cynNa v 1.7, dogNa v 1.7, ratNa v 1.7, and musNa v 1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1235403-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12883. | |
| PF-05180999 | PF-05180999 (PF-999) is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC 50 of 1.6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-999. CAS No. 1394033-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111371. | |
| PF-06372865 | PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABA A positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABA A receptors containing α1/α2/α3/α5 subunits ( K i s of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. PF-06372865 can across the blood-brain barrier (BBB). PF-06372865 has anxiolytic activity and has the potential for epilepsy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1614245-70-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120874. | |
| PF-06648671 | PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimers disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1587727-31-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120789. | |
| PF-06726304 | PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with K i s of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1616287-82-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103682. | |
| PF-06835919 | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK) , with IC 50 s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketohexokinase inhibitor 1. CAS No. 2102501-84-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00461. | |
| PF-06939999 | PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRMT5-IN-3. CAS No. 2159123-14-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131493. | |
| PF-06952229 | PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1801333-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136244. | |
| PF-07258669 | PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2755890-53-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148349. | |
| PF-07265807 | PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC 50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412356-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147218. | |
| PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC 50 value of 21 nM. PF-07284892 decreases the expression of pERK [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-558. CAS No. 2498597-94-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-153740. | |
| PF-3758309 | PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 ( K d = 2.7 nM; K i =18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03758309. CAS No. 898044-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13007. | |
| PF-3845 | PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380. | |
| PF-4708671 | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K i of 20 nM and IC 50 of 160 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255517-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15773. | |
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