MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| N-Boc-L-glutamic acid | N-Boc-L-glutamic acid is a glutamic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 2419-94-5. Pack Sizes: 25 g; 100 g; 500 g. Product ID: HY-W002169. |  |
| N-Boc-L-phenylalanine methyl ester | N-Boc-L-phenylalanine methyl ester is a phenylalanine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 51987-73-6. Pack Sizes: 25 g; 100 g. Product ID: HY-30090. | |
| N-Boc-L-tert-Leucine | N-Boc-L-tert-Leucine is a leucine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 62965-35-9. Pack Sizes: 500 g. Product ID: HY-59260. | |
| N-Boc-N-methylethylenediamine | tert-Butyl (2-aminoethyl)(methyl)carbamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 121492-06-6. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-40174A. | |
| N-Boc-nortropinone | N-Boc-nortropinone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 185099-67-6. Pack Sizes: 25 g. Product ID: HY-W001484. | |
| N-Boc-PEG1-bromide | N-Boc-PEG1-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG1-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 164332-88-1. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-130503. | |
| N-Boc-piperazine | N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57260-71-6. Pack Sizes: 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-30105. | |
| N-Boc-trans-4-fluoro-L-proline | N-Boc-trans-4-fluoro-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Peptides. CAS No. 203866-14-2. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W046071. | |
| NBQX | NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FG9202. CAS No. 118876-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15068. | |
| NBQX disodium | NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FG9202 disodium. CAS No. 479347-86-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15068A. | |
| N-Bromoacetamide | N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79-15-2. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-131899. | |
| NBTGR | NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport ; inhibits adenosine uptake with a K i of 70 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 13153-27-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108322. | |
| N-Butanoyl-L-homoserine lactone | N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C4-HSL; N-Butyryl-L-homoserine lactone. CAS No. 67605-85-0. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-114816. | |
| N-Butyl cinnamate | N-Butyl cinnamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 538-65-8. Pack Sizes: 10 mM * 1 mL; 10 g. Product ID: HY-126070. | |
| N-Butyl-N-(4-hydroxybutyl)nitrosamine | N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3817-11-6. Pack Sizes: 100 mg. Product ID: HY-W755252. | |
| N-Butylthiophosphoric triamide | N-Butylthiophosphoric triamide (NBPT) is a potent urease inhibitor. Butylthiophosphoric triamide inhibits nitrification and reduces the conversion of urea to NH3 gas [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NBPT. CAS No. 94317-64-3. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-107199. | |
| N-Butyrylglycine | N-Butyrylglycine is a Glycine (HY-Y0966) derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 20208-73-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-113119. | |
| NCAO | N-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase ( ODC ) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC 50 values ranging from 1 to 50.6 μM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 20584-81-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-160843. | |
| N-Caproicacid-d3 sodium | N-caproicacidsodiumsalt-d 3 is the deuterium labeled N-caproicacidsodiumsalt[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Hexanoate-d3 sodium. CAS No. 1219794-91-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W099696S1. | |
| N-Caproicacid sodium | N-caproicacid sodium is an anionic surfactant, sodium n-caproic acid. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Hexanoate sodium. CAS No. 10051-44-2. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-W099696. | |
| N-Carbamoyl-L-aspartic acid | N-Carbamoyl-L-aspartic acid is intermediate of pyrimidine (HY-Y0519) metabolism. N-Carbamoyl-L-aspartic acid can be used to measure enzyme activity of dihydroorotase (DHOse) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: L-Ureidosuccinic acid. CAS No. 13184-27-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-128425A. | |
| NCB-0846 | NCB-0846 is an orally active, selective inhibitor for Wnt , that inhibits Traf2- and Nck-interacting kinase ( TNIK ) with an IC 50 of 21?nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1792999-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100830. | |
| N-Cbz-hydroxy-L-proline | N-Cbz-hydroxy-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Cbz-Hydroxy-L-Proline. CAS No. 13504-85-3. Pack Sizes: 5 g; 10 g. Product ID: HY-W016042. | |
| NCGC00351170 | NCGC00351170 is an antiplatelet agent that disrupts the calcium and integrin-binding protein 1 (CIB1)-α IIb β 3 interaction. NCGC00351170 inhibits thrombin-induced human platelet aggregation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 886536-76-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162558. | |
| N-Chlorosuccinimide | N-Chlorosuccinimide can enhance the antimicrobial effect of Benzalkonium chloride (HY-B2232) on biofilm Pseudomonas aeruginosa [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Succinchlorimide. CAS No. 128-09-6. Pack Sizes: 10 mM * 1 mL; 500 g. Product ID: HY-Y0532. | |
| NCS-382 sodium | NCS-382 (sodium) is a potent GABA receptor antagonist. NCS-382 (sodium) has anti-sedative and anti-hypnotic activities and can be used in research related to neurological diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131733-92-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W008645. | |
| NCT-501 | NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 ?M). Uses: Scientific research. Group: Signaling pathways. CAS No. 1802088-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18768. | |
| NCT-503 | NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1916571-90-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101966. | |
| ND-646 | ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1434639-57-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101842. | |
| NDB | NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1660153-08-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138937. | |
| N-Decanoyl-L-homoserine lactone | N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species ( ROS ), increases the activity of mitogen-activated protein kinase 6 ( MPK6 ), and induces nitric oxide ( NO ) production in Arabidopsis roots [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C10-HSL. CAS No. 177315-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136409. | |
| N-Desalkylflurazepam | N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Norfludiazepam. CAS No. 2886-65-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-106454. | |
| N-Desethyl amodiaquine | N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC 50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79352-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128554. | |
| N-Desethyl amodiaquine dihydrochloride | N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC 50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79049-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128554A. | |
| N-Desmethyl clomipramine hydrochloride | N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride. CAS No. 29854-14-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12388A. | |
| N-Desmethylclozapine | N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist ( EC 50 =115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Norclozapine; Desmethylclozapine; Normethylclozapine. CAS No. 6104-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-G0021. | |
| N-desmethyl Enzalutamide | N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-desmethyl MDV 3100. CAS No. 1242137-16-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-70002A. | |
| N-Desmethyl imatinib | N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Norimatinib; Imatinib metabolite N-Desmethyl imatinib. CAS No. 404844-02-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-G0017. | |
| N-Desmethylolanzapine | N-Desmethylolanzapine is an antipsychotic drug. The formation of N-Desmethylolanzapine correlates with the level and activity of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine can be used in the study of antipsychotic drugs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Demethylolanzapine; LY170055. CAS No. 161696-76-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-W009247. | |
| N-Desmethyl Sildenafil | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desmethylsildenafil; UK-103,320. CAS No. 139755-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117605. | |
| N-Desmethyltamoxifen hydrochloride | N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15917-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129099A. | |
| NDI-091143 | NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375840-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127111. | |
| NDI-101150 | NDI-101150 is an orally active, potent and selective hematopoietic progenitor cell kinase 1 ( HPK1 ) inhibitor. NDI-101150 enhances T cell activation and inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2628486-22-4. Pack Sizes: 1 mg. Product ID: HY-159643. | |
| N-(Diphenylmethylene)glycine tert-butyl ester | N-(Diphenylmethylene)glycine tert-butyl ester is a dye, also as the raw material and intermediate for organic syntheses [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 81477-94-3. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-Y1778. | |
| N-Dodecanoyl-DL-homoserine lactone | N-Dodecanoyl-DL-homoserine lactone is a serine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 18627-38-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W044573. | |
| N-dodecanoyl-L-Homoserine lactone | N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C12-HSL. CAS No. 137173-46-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118697. | |
| NDSB-195 | NDSB-195 is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 160255-06-1. Pack Sizes: 100 mg. Product ID: HY-135484. | |
| NDSB-201 | NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-(1-Pyridinio)-1-propanesulfonate. CAS No. 15471-17-7. Pack Sizes: 25 g. Product ID: HY-W014837. | |
| NDSB-256 | NDSB-256 is a non-stain remover sulfabetaine. NDSB-256 prevents protein aggregation and promotes denaturation of chemically and thermally denatured proteins [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-(Benzyldimethylammonio)propane-1-sulfonate; PDA. CAS No. 81239-45-4. Pack Sizes: 1 g; 5 g. Product ID: HY-W011831. | |
| NDSB 256-4T | NDSB 256-4T is a non-washing sulfabetaine compound. NDSB-256-4T prevents protein aggregation and promotes protein folding by interacting with early folding intermediates [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-(4-(tert-Butyl)pyridinio)-1-propanesulfonate. CAS No. 570412-84-9. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W127622. | |
| NE-100 hydrochloride | NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC 50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 149409-57-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101484A. | |
| Neamine tetrahydrochloride | Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15446-43-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-115349. | |
| Nebentan potassium | Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ET A receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ 125 I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K i of 0.697 nM and 569 nM, respectively [1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YM598. CAS No. 342005-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106994A. | |
| Nebicapone | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIA 3-202. CAS No. 274925-86-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106405. | |
| Nebivolol | Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 065824. CAS No. 118457-14-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0203. | |
| Nebivolol hydrochloride | Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 065824 hydrochloride. CAS No. 152520-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0203A. | |
| Neboglamine hydrochloride | Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CR-2249 hydrochloride; XY-2401 hydrochloride. CAS No. 2759182-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114753A. | |
| Necitumumab | Necitumumab is a human IgG monoclonal antibody directed against EGFR. Necitumumab can be used for research of NSCLC, colorectal cancer, etc [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 906805-06-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9964. | |
| Necrocide 1 | Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1247028-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14307. | |
| Necroptosis-IN-1 | Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391980-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-135826. | |
| Necroptosis-IN-3 | Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis [1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1 [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 547698-18-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148454. | |
| Necrostatin-1 | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC 50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase ( EC 50 =182 nM). Necrostatin-1 is also an IDO inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15760. | |
| Necrostatin-1 (inactive control) | Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1 (inactive control). CAS No. 64419-92-7. Pack Sizes: 1 mg. Product ID: HY-121954. | |
| Necrostatin 2 | Necrostatin 2 is a potent necroptosis inhibitor. EC 50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 852391-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14622. | |
| Necrostatin 2 racemate | Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1. CAS No. 852391-15-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-14622A. | |
| Necrostatin-7 | Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC 50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-7. CAS No. 351062-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117200. | |
| Necrosulfonamide | Necrosulfonamide, a necroptosis and gasdermin D inhibitor, selectively targets (MLKL). Necrosulfonamide prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a key substrate of RIP3 in the induction of necrosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1360614-48-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100573. | |
| Ned 19 | Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 874374-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-103316A. | |
| Nedaplatin | Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 375101D. CAS No. 95734-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13700. | |
| Nedisertib | Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Peposertib; M3814. CAS No. 1637542-33-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101570. | |
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