MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Nialamide | Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. Uses: Scientific research. Group: Signaling pathways. CAS No. 51-12-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1199. |  |
| Niaprazine | Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 27367-90-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105542. | |
| NIBR189 | NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1599432-08-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12336. | |
| NIBR-LTSi | NIBR-LTSi is an orally active and selective LATS kinase inhibitor. NIBR-LTSi can activate YAP signaling. NIBR-LTSi promotes stem cell proliferation, maintains stemness and blocks differentiation. NIBR-LTSi accelerates liver regeneration following extended hepatectomy in mice[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160769. | |
| Nicarbazin | Nicarbazin is an effective anticoccidial agent for chickens [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330-95-0. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-107814. | |
| Nicardipine | Nicardipine (YC-93 free base) is a calcium channel blocker with an IC 50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YC-93 free base. CAS No. 55985-32-5. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-12515. | |
| Nicardipine hydrochloride | Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC 50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YC-93. CAS No. 54527-84-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-12515A. | |
| Nicardipine (hydrochloride) (Standard) | Nicardipine (hydrochloride) (Standard) is the analytical standard of Nicardipine (hydrochloride). This product is intended for research and analytical applications. Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC 50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 54527-84-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12515AR. | |
| NICE-01 | NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for co-import and nuclear trapping of cytosolic proteins[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AP1867-PEG2-JQ1; AP-PEG2-JQ1. CAS No. 2982819-94-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-156214. | |
| Nicergoline | Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α 1A -adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 27848-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0702. | |
| Niclosamide | Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research [1]. Niclosamide is a STAT3 inhibitor with an IC 50 of 0.25 μM in HeLa cells [4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells [2] [3] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY2353. CAS No. 50-65-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0497. | |
| Niclosamide olamine | Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research [1]. Niclosamide olamin is a STAT3 inhibitor with an IC 50 of 0.25 μM in HeLa cells [4]. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells [2] [3] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY2353 olamine. CAS No. 1420-04-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0497C. | |
| Niclosamide (Standard) | Niclosamide (Standard) is the analytical standard of Niclosamide. This product is intended for research and analytical applications. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research [1]. Niclosamide is a STAT3 inhibitor with an IC 50 of 0.25 μM in HeLa cells [4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells [2] [3] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 50-65-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0497R. | |
| Nicodicosapent | Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP) , a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1269181-69-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17640. | |
| Nicorandil | Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K + channels and cardiac ATP-sensitive K + channels (K ATP ). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SG-75. CAS No. 65141-46-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0341. | |
| Nicosulfuron | Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs) , which is proming for maize cultivation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 111991-09-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B1876. | |
| Nicotelline | Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nicotellin. CAS No. 494-04-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135560. | |
| Nicotiflorin | Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. Uses: Scientific research. Group: Natural products. CAS No. 17650-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N1475. | |
| Nicotinamide | Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity ( IC 50 : 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD + , ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti- HBV activity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Niacinamide; Nicotinic acid amide. CAS No. 98-92-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0150. | |
| Nicotinamide-d4 | Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Niacinamide-d4; Nicotinic acid amide-d4. CAS No. 347841-88-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0150S. | |
| Nicotinamide-guanine dinucleotide sodium | Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2600354-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164690A. | |
| Nicotinamide N-oxide | Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor. Uses: Scientific research. Group: Natural products. CAS No. 1986-81-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-101407. | |
| Nicotinamide riboside chloride | Nicotinamide riboside Chloride, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities [1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimers disease [2]. Uses: Scientific research. Group: Natural products. CAS No. 23111-00-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-123033A. | |
| Nicotinic acid riboside | Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 17720-18-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W104368. | |
| Nicotinohydrazide | Nicotinohydrazide (Nicotinic acid hydrazide) is a small molecular compound [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nicotinic acid hydrazide. CAS No. 553-53-7. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-W012617. | |
| Nicotinuric acid | Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid. Uses: Scientific research. Group: Natural products. CAS No. 583-08-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-113353. | |
| Nidanilimab (Nadunolimab) | Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1? and IL1? signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) [1][2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanilimab). CAS No. 2171061-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99379. | |
| Nidufexor | Nidufexor (LMB763) is an orally-available farnesoid X receptor ( FXR ) agonist for the research of nonalcoholic steatohepatitis (NASH) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LMB763. CAS No. 1773489-72-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109096. | |
| Nifedipine | Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-a-1040. CAS No. 21829-25-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0284. | |
| Nifekalant hydrochloride | Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC 50 of 10 μM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MS-551. CAS No. 130656-51-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0772A. | |
| Nifenalol hydrochloride | Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5704-60-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100952. | |
| Nifenazone | Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders. Uses: Scientific research. Group: Signaling pathways. CAS No. 2139-47-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17475. | |
| Niflumic acid | Niflumic acid is a calcium-activated chloride channel blocker and COX -2 inhibitor with the IC 50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8 / Bid / Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4394-00-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0493. | |
| Nifuratel | Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NF 113; SAP 113; Methylmercadone. CAS No. 4936-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0059. | |
| Nifuroxazide | Nifuroxazide is an effective inhibitor of STAT3 , also exerts potent anti-tumor and anti-metastasis activity. Nifuroxazide is an orally active nitrofuran antibiotic. Uses: Scientific research. Group: Signaling pathways. CAS No. 965-52-6. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-B1436. | |
| Nifurpirinol | Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic ? cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: P-7138. CAS No. 13411-16-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135470. | |
| Nifurtimox | Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi , has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase ( LDH ). Uses: Scientific research. Group: Signaling pathways. CAS No. 23256-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W040073. | |
| Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 28380-24-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127019. | |
| Nigericin sodium salt | Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 28643-80-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100381. | |
| (+)-Niguldipine hydrochloride | (+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID 50 of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED 30 of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-Niguldipine hydrochloride. CAS No. 113145-69-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101390. | |
| Nikethamide | Nikethamide (N,N-Diethylnicotinamide), one of the respiratory central stimulants, has the potential for respiratory failure research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N,N-Diethylnicotinamide. CAS No. 59-26-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1280. | |
| Nikkomycin Z | Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 59456-70-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-19593. | |
| NIK SMI1 | NIK SMI1 is a potent, selective NF-?B inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM. NIK SMI1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1660114-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112433. | |
| Nile blue chloride | Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2381-85-3. Pack Sizes: 1 g. Product ID: HY-W110898. | |
| Nile Red | Nile red (Nile blue oxazone) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Nile Blue A oxazone; Phenoxazone 9. CAS No. 7385-67-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-D0718. | |
| Nilotinib | Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMN107. CAS No. 641571-10-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10159. | |
| Nilotinib monohydrochloride monohydrate | Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMN107 monohydrochloride monohydrate. CAS No. 923288-90-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10159A. | |
| Nilutamide | Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nilandron; RU 23908. CAS No. 63612-50-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-13702. | |
| Nilvadipine | Nilvadipine is a potent calcium channel antagonist, and the IC 50 value is around 0.1 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FK235; FR34235. CAS No. 75530-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14284. | |
| NIM811 | NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: (Melle-4)cyclosporin; SDZ NIM811. CAS No. 143205-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0025. | |
| Nimbin | Nimbin is a intermediate limonoid isolated from Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 5945-86-8. Pack Sizes: 1 mg. Product ID: HY-N3187. | |
| Nimesulide | Nimesulide is a selective COX-2 inhibitor, with IC 50 s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC 50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R805. CAS No. 51803-78-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0363. | |
| Nimodipine | Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-e 9736. CAS No. 66085-59-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0265. | |
| Nimorazole | Nimorazole (K-1900), a 2-nitroimidazole, is a hypoxic cell-radiation sensitizer. Nimorazole has anti-infective and anti-protozoal against trichomoniasis. Nimorazole has the potential for head and neck cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K-1900. CAS No. 6506-37-2. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16349. | |
| Nimotuzumab | Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a K D of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 780758-10-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9968. | |
| Nimustine hydrochloride | Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis , commonly used in chemotherapy for glioblastomas [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACNU. CAS No. 55661-38-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13703A. | |
| Ninerafaxstat | Ninerafaxstat (IMB-1018972) is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat can be used for research on cardiovascular diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMB-1018972; IMB-101. CAS No. 2254741-41-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139577. | |
| Ningetinib | Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor ( TKI ) with IC 50 s of 6.7, 1.9 and <1.0 nM for c-Met , VEGFR2 and Axl , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394820-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107145A. | |
| Ningetinib Tosylate | Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor ( TKI ) with IC 50 s of 6.7, 1.9 and <1.0 nM for c-Met , VEGFR2 and Axl , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394820-77-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107145. | |
| Ninhydrin | Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins. Uses: Scientific research. Group: Fluorescent dye. CAS No. 485-47-2. Pack Sizes: 10 mM * 1 mL; 25 g; 50 g; 100 g. Product ID: HY-D0908. | |
| Nintedanib | Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3 , FGFR1/2/3 and PDGFRα/β with IC 50 s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBF 1120. CAS No. 656247-17-5. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50904. | |
| Nintedanib esylate | Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3 , FGFR1/2/3 and PDGFRα/β with IC 50 s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBF 1120 esylate. CAS No. 656247-18-6. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-11106. | |
| N-Iodosuccinimide | N-Iodosuccinimide is a biological material or organic compound that can be used in life science research [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 516-12-1. Pack Sizes: 50 g; 100 g; 500 g. Product ID: HY-ER017. | |
| Nipecotic acid | Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid ( GABA ) uptake in vitro. Nipecotic acid can also directly activate GABA A -like chloride channels , with an EC 50 of approximately 300 μM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine. CAS No. 498-95-3. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-69359. | |
| Niperotidine | Niperotidine is a histamine H2-receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 84845-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15539. | |
| Nipocalimab | Nipocalimab (M281) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor ( FcRn ) at both endosomal pH 6.0 and extracellular pH 7.6 [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: M281. CAS No. 2211985-36-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99037. | |
| Niraparib | Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827. CAS No. 1038915-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10619. | |
| Niraparib hydrochloride | Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 hydrochloride. CAS No. 1038915-64-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619A. | |
| Niraparib tosylate | Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC 50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 tosylate. CAS No. 1038915-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619B. | |
| Niraparib tosylate hydrate | Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 tosylate hydrate. CAS No. 1613220-15-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619E. | |
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