MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| NP-1815-PX sodium | NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1239578-80-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150270A. |  |
| N-Palmitoyl Taurine | Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered. N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation. Uses: Scientific research. Group: Signaling pathways. CAS No. 83982-06-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120965. | |
| NPB | NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99 , with an IC 50 of 0.41 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247491-97-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119368. | |
| NPBA | NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K + channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 524033-40-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139064. | |
| NP-BSA | NP-BSA (4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin) is an antigen-adjuvant conjugate of 4-Hydroxy-3-nitrophenylacetyl (NP) conjugated to bovine serum albumin (BSA), which is an immune complex. By conjugating antigens to protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and can enhance cross-presentation and the generation of antigen-specific T cells[1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin. Pack Sizes: 1 mg. Product ID: HY-NP141. | |
| N-(p-Coumaroyl) Serotonin | N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFR?, ERK1/2 and caspase-8 with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits glioblastoma cells (U251MG, T98G) with IC50 of 48-81 ?M, while the IC50 for normal fibroblasts is 181-197 ?M. N-(p-Coumaroyl) Serotonin inhibits PDGF signaling (reducing receptor phosphorylation), blocks Ca2+ influx, and induces apoptosis (activating caspase-8). N-(p-Coumaroyl) Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma[1][2][3]. Uses: Scientific research. Group: Natural products. CAS No. 68573-24-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129440. | |
| NP-G2-044 | NP-G2-044 is a potent, orally active fascin inhibitor, with an IC 50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1807454-59-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125506. | |
| N-Phenethylbenzamide | N-Phenethylbenzamide is an active compound. N-Phenethylbenzamide can be extracted from Liriodendron tulipifera. N-Phenethylbenzamide can be used for the research of inflammatory diseases [1]. Uses: Scientific research. Group: Natural products. CAS No. 3278-14-6. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-32135. | |
| N-Phenylacrylamide | N-Phenylacrylamide is a special polymer showing high affinity with Ochratoxin A, a colorless and crystalline mycotoxin compound. N-Phenylacrylamide can be applied in the field of mycotoxin extraction, and be used for the security research of agricultural commodities and foods made from cereals and grapes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2210-24-4. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W018582. | |
| N-Phenylnaphthalen-1-amine | N-Phenylnaphthalen-1-amine is a fluorescence probe for odorant-binding proteins (OBP) with a dissociation constant of 1.67 μM. N-Phenylnaphthalen-1-amine exhibits an excitation wavelength of 337 nM and an emission wavelength of 407 nM [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 90-30-2. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-W009756. | |
| NP-KLH,Type II | NP-KLH,Type II (4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II) is a 4-Hydroxy-3-nitrophenylacetyl (NP) hapten. NP-KLH,Type II can be used for study as a carrier protein in immunological research[1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II. Pack Sizes: 1 mg; 5 mg. Product ID: HY-NP133A. | |
| NP-OVAL (Ovalbumin) | NP-OVAL (Ovalbumin) is an immunoconjugate. NP-OVAL (Ovalbumin) is used as a model antigen for the study of multiple myeloma[1]. Uses: Scientific research. Group: Biochemical assay reagents. Pack Sizes: 1 mg; 5 mg. Product ID: HY-NP138. | |
| NPPB | NPPB is a blocker of the outwardly rectifying chloride channel ( ORCC ). Uses: Scientific research. Group: Signaling pathways. CAS No. 107254-86-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101012. | |
| NP-PE (Phycoerythrin) | NP-PE (Phycoerythrin) is an immune complex. The formation and transport of NP-PE (Phycoerythrin) depends on the complement system, specifically through the complement receptors CR1 and CR2. These receptors are expressed on the surface of B cells and help B cells capture and transport immune complexes. NP-PE (Phycoerythrin) can be used to study the mechanisms by which B cells capture and transport immune complexes in lymph nodes[1]. Uses: Scientific research. Group: Biochemical assay reagents. Pack Sizes: 1 mg. Product ID: HY-NP137. | |
| N-Propargylglycine | N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH). N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 58160-95-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142035. | |
| NPS-2143 | NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca 2+ concentrations ( IC 50 =43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-262470A. CAS No. 284035-33-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10007. | |
| NPS-2143 hydrochloride | NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca 2+ concentrations ( IC 50 =43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-262470A hydrochloride. CAS No. 324523-20-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10171. | |
| NPS 2390 | NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 [1]. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 226878-01-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11095. | |
| NQ301 | NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC 50 of 10 mg/mL. Uses: Scientific research. Group: Signaling pathways. CAS No. 130089-98-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101054. | |
| NQO1 substrate | NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304503-05-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114315. | |
| NR2F6 modulator-1 | NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. NR2F6 modulator-1 can be used for researching immune modulation and modulation of cancer stem cell activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 904449-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147228. | |
| Nrf2 activator-1 | Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 ( Nrf2 ). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230697-41-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145390. | |
| Nrf2 activator-12 | Nrf2 activator-12 (compund 10v) potently activates Nrf2 (EC50=83.5 nM) and exhibits promising pharmacological properties, reversing disease progression and alleviating demyelination in an experimental autoimmune encephalomyelitis mouse model [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3020661-05-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169201. | |
| Nrf2-Activator-12G | Nrf2-Activator-12G (compd 12g) is an activator of Nrf2. Nrf2-Activator-12G induces the expression of nrf2-dependentantioxidant enzymes at both mRNA and protein levels in DAergic neuronal cell. Nrf2-Activator-12G can used in study Parkinsons Disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1554271-18-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-115849. | |
| Nrf2 degrader 1 | Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3025286-00-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162307. | |
| Nrf2-IN-1 | Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1610022-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101025. | |
| Nrf2-IN-3 | Nrf2-IN-3 (Compound R16) is a small-molecule NRF2 inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6325-13-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149508. | |
| NRP1 antagonist 1 | NRP1 antagonist 1 (compound 12a) is a potent NRP1 antagonist with an IC 50 of 19.1 μM. NRP1 antagonist 1 has the potential for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2569598-01-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133034. | |
| NRX-252114 | NRX-252114 is a potent enhancer of the interaction between ?-catenin, and its cognate E3 ligase, SCF?-TrCP. NRX-252114 enhances the binding of pSer33/S37A ?-catenin peptide for ?-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant ?-catenin degradation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763260-39-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111836. | |
| NRX-252262 | NRX-252262 is a potent enhancer of the interaction between ?-Catenin, and its cognate E3 ligase, SCF?-TrCP, induces mutant ?-catenin degradation, with an EC50 of 3.8 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2438637-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111760. | |
| NS 11021 | NS 11021 is a potent and specific Ca 2+ -activated big-conductance K + Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 956014-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13103. | |
| NS-1619 | NS-1619 is an opener of large conductance Ca 2+ -activated K + (BK) channel. NS-1619 is a highly effective relaxant with an EC 50 of about 10 - 30 μM in several smooth muscles of blood vessels and other tissues [1]. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 153587-01-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-12496. | |
| NS1643 | NS1643 is a partial agonist of human ether-a-go-go-related gene ( hERG ) K + channels with an EC 50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448895-37-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16916. | |
| NS-2028 | NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity[1]. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 ?M)[1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 204326-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12379. | |
| NS2B/NS3-IN-2 | NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 μM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3010940-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144612. | |
| NS383 | NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC 50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 309711-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-131879. | |
| NS3861 | NS3861 is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216853-59-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110121A. | |
| NS3861 fumarate | NS3861 fumarate is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216853-60-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110121. | |
| NS-398 | NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 ( COX-2 ) activity, with an IC 50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 123653-11-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13913. | |
| NS8593 hydrochloride | NS8593 hydrochloride is a potent and selective small conductance Ca 2+ -activated K + channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3 -mediated currents with a K d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca 2+ -dependently ( K d s of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+ ), and does not affect the Ca 2+ -activated K + channels of intermediate and large conductance (hIK and hBK channels, respectively) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875755-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110105. | |
| NSAH | NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC 50 of 32 μM and cell-based IC 50 of ~250 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1099592-35-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114503. | |
| N-Salicyloyltryptamine | N-Salicyloyltryptamine acts on voltage-dependent Na + , Ca 2+ , and K + ion channels inhibitor. N-Salicyloyltryptamine inhibits K + currents with an IC 50 value of 34.6 μM ( I to ). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect [1] - [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 31384-98-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-147377. | |
| NSC 107512 | NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22242-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-141687. | |
| NSC 15364 | NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4550-72-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108937. | |
| NSC16168 | NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 ?M. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6837-93-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100690. | |
| NSC 185058 | NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39122-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125169. | |
| NSC 194308 | NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 90379-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153736. | |
| NSC 228155 | NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 ?M[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113104-25-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101084. | |
| NSC232003 | NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. Uses: Scientific research. Group: Signaling pathways. CAS No. 1905453-18-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-103236. | |
| NSC 23766 | NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 733767-34-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723. | |
| NSC 23766 trihydrochloride | NSC 23766 trihydrochloride is an inhibitor of Rac1 activation. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177865-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723A. | |
| NSC23925 | NSC23925 is a novel, selective and effective P-glycoprotein ( Pgp ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 858474-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19626. | |
| NSC2805 | NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 ?M. NSC2805 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4371-34-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134417. | |
| NSC319726 | NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZMC1. CAS No. 71555-25-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18634. | |
| NSC 405020 | NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 7497-7-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15827. | |
| NSC 42834 | NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JAK2 Inhibitor V; Z3. CAS No. 195371-52-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15480. | |
| NSC59984 | NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway [1]. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 803647-40-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19726. | |
| NSC 617145 | NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203115-63-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110185. | |
| NSC632839 | NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 ?M, 37±1 ?M, and 9.8±1.8 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 157654-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100708. | |
| NSC 663284 | NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 ?M. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively[1]. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM)[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA-3003-1. CAS No. 383907-43-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100034. | |
| NSC668394 | NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 ?M. NSC668394 inhibit ezrin T567 phosphorylation caused by PKC? primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 382605-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115492. | |
| NSC689857 | NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 ?M for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 ?M). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 241127-79-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123578. | |
| NSC697923 | NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-?B signaling. Antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 343351-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13811. | |
| NSC 74859 | NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S3I-201. CAS No. 501919-59-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15146. | |
| NSC-87877 | NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 ?M, 0.355 ?M shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 56990-57-9. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18756. | |
| NSC 95397 | NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B))[1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93718-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108543. | |
| NSD2-PWWP1-IN-2 | NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor with an IC 50 value of 1.49 μM. NSD2-PWWP1-IN-2 has the potential for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2797183-32-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171120. | |
| N-sec-butyl Pentylone hydrochloride | N-sec-butyl Pentylone hydrochloride is a cathinone. Uses: Scientific research. Group: Signaling pathways. CAS No. 17763-05-2. Pack Sizes: 1 mg. Product ID: HY-402939A. | |
| NSI-189 | NSI-189 is an orally active chemical entity with enhanced neurogenic activity. NSI-189 up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. NSI-189 exhibits anti-depressant effect. NSI-189 enhances synaptic plasticity and reduces cognitive dysfunction. NSI-189 holds potential for psychiatric disorder research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1270138-40-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13999. | |
| NSI-189 phosphate | NSI-189 is an orally active chemical entity with enhanced neurogenic activity. NSI-189 up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. NSI-189 exhibits anti-depressant effect. NSI-189 enhances synaptic plasticity and reduces cognitive dysfunction. NSI-189 holds potential for psychiatric disorder research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1270138-41-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13999A1. | |
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