MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SARS-CoV-IN-3 | SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC 50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC 50 s of 11.7 and 20.4 nM; and IC 90 s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1 -induced cytopathic effect with an EC 50 of 10 μM in MT-4 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 888958-27-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-135858. |  |
| Saruparib | Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC 50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD5305. CAS No. 2589531-76-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132167. | |
| (S)-Atenolol | (S)-Atenolol is a potent beta-adrenoreceptor blocker. (S)-Atenolol has the potential for the research of cardiovascular disorder [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93379-54-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-17498A. | |
| Satoreotide | Satoreotide (JR11) is a SSTR2 antagonist. Satoreotide is usually conjugated with radiolabeled chelators used in neuroendocrine tumor imaing [1]. Uses: Scientific research. Group: Peptides. Alternative Names: JR11. CAS No. 1801415-23-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10137. | |
| Satralizumab | Satralizumab, a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1535963-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99112. | |
| Satraplatin | Satraplatin is an alkylating agent, with potent antitumor effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS182751; BMY45594; JM216. CAS No. 129580-63-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17576. | |
| Sauchinone | Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 177931-17-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0613. | |
| Savolitinib | Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC 50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Volitinib; HMPL-504; AZD-6094. CAS No. 1313725-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15959. | |
| Saxagliptin | Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) ( K i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-477118. CAS No. 361442-04-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10285. | |
| Saxagliptin hydrate | Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) ( K i = 0.6-1.3 nM) inhibitor. Saxagliptin hydrate has the peotential for type 2 diabetes mellitus research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-477118 hydrate. CAS No. 945667-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10285A. | |
| Saxagliptin hydrochloride | Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) ( K i = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-477118 hydrochloride. CAS No. 709031-78-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16448. | |
| SB-200646A | SB-200646A is the first selective 5-HT 2B/2C over 5-HT 2A receptor antagonist with pK i values of 7.5, 6.9 and 5.2 for 5-HT 2B , 5-HT 2C and 5-HT 2A , respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 143797-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103129. | |
| SB 202190 | SB 202190 is a selective p38 MAP kinase inhibitor with IC 50 s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a K d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits [1] [2]. SB202190 induces autophagy [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 152121-30-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10295. | |
| SB 202190 hydrochloride | SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC 50 s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a K d of 38 nM. SB 202190 hydrochloride has anti-cancer activity [1] [2]. SB202190 hydrochloride induces autophagy [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 350228-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10295A. | |
| SB 204990 | SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. Uses: Scientific research. Group: Signaling pathways. CAS No. 154566-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16450. | |
| SB 206553 hydrochloride | SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT 2B / 5-HT 2C receptor antagonist (rat 5-HT 2B pA2 = 8.89, human 5-HT 2C pKi = 7.92) [1]. SB 206553 possesses anxiolytic-like properties [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1197334-04-5. Pack Sizes: 5 mg. Product ID: HY-103135. | |
| SB-216 | SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756818-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144898. | |
| SB 216763 | SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC 50 s of 34.3 nM for both GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 280744-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12012. | |
| SB-222200 | SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174635-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15722. | |
| SB-224289 hydrochloride | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-224289A. CAS No. 180084-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101105A. | |
| SB 242235 | SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC 50 of 1.0?μM in primary human chondrocytes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193746-75-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18306. | |
| SB-258585 hydrochloride | SB-258585 is a high affinity ligand for the 5-HT 6 receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT 6 receptors. SB-258585 can be used to label recombinant and natural 5-HT 6 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216468-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103141. | |
| SB-269970 | SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK i of 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 201038-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15370. | |
| SB-269970 hydrochloride | SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK i of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-269970A. CAS No. 261901-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15370A. | |
| SB 271046 Hydrochloride | SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC 50 =0.16 μM) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 271046A. CAS No. 209481-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14336A. | |
| SB-277011 hydrochloride | SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D 3 receptor (D 3 R) antagonist with K i values of 10.7 nM and 11.2 nM at rodent and human D 3 R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK i s of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT 1B , and 5-HT 1D receptors, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-277011A hydrochloride. CAS No. 215804-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10847B. | |
| SB-328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC 50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006)-resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 247580-43-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103363. | |
| SB-334867 | SB-334867 (SB 334867A) is an excellent,selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 334867A. CAS No. 249889-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10895. | |
| SB-334867 free base | SB-334867 free base (SB334867A free base) is an excellent, selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB334867A free base. CAS No. 792173-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10895A. | |
| SB-366791 | SB-366791 is a potent and selective vanilloid receptor ( VR1/TRPV1 ) antagonist ( IC 50 =5.7 nM). SB-366791 can be used for the research of inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 472981-92-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12245. | |
| SB-399885 hydrochloride | SB-399885 hydrochloride is a 5-HT 6 receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 402713-81-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103099. | |
| SB-408124 | SB-408124 is a non-peptide OX1 receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 288150-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-70068. | |
| SB-408124 Hydrochloride | SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-90-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-76612. | |
| SB 415286 | SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α , with an IC 50 of 77.5 nM, and a K i of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 264218-23-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15438. | |
| SB-431542 | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10431. | |
| SB-431542 (Standard) | SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-10431R. | |
| SB 525334 | SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC 50 of 14.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 356559-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12043. | |
| SB-590885 | SB-590885 is a potent B-Raf inhibitor with a K i of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 405554-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10966. | |
| SB-649868 | SB-649868 is a potent and selective orally active orexin ( OX ) 1 and OX 2 receptor antagonist ( pK i =9.4 and 9.5 at the OX 1 and OX 2 receptor, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK649868. CAS No. 380899-24-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10806. | |
| SB-674042 | SB-674042 is a potent and selective non-peptide orexin OX 1 receptor antagonist (K d =5.03 nM), exhibits 100-fold selectivity for OX 1 over OX 2 receptors with IC 50 values of 3.76 nM and 531 nM, respectively [1] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 483313-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10898. | |
| SB-699551 | SB-699551 is a potent and selective 5-HT5A antagonist with a K i value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1 , and decreases the phosphorylation levels of AKT , PRAS40 , P70S6K , FOXO1 , and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 864741-95-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-103100. | |
| SB-743921 hydrochloride | SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5) , with a K i of 0.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 940929-33-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12069. | |
| sBADA | sBADA is a potent green fluorescent dye. sBADA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA is used to label peptidoglycans in bacterial cell walls in situ. (λ ex =490 nm, λ em =510 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2376838-11-6. Pack Sizes: 1 mg. Product ID: HY-D1690A. | |
| (S)-BAY 73-6691 | (S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 794568-91-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104028B. | |
| (S)-(-)-Bay-K-8644 | (S)-(-)-Bay-K-8644 is an agonist of L-type Ca 2+ channel. (S)-(-)-Bay-K-8644 activates Ba 2+ currents ( I Ba ) ( EC 50 =32 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 98625-26-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15124. | |
| SBFI-AM | SBFI-AM is a Na + selective fluorescent indicator. SBFI-AM shows selectivity for Na + over K + [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 129423-53-6. Pack Sizes: 281 μg (5 mM * 50 μL in DMSO). Product ID: HY-126831. | |
| SC-10 | SC-10 is a direct activator of PKC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 102649-79-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100931. | |
| SC-2001 | SC-2001 is a compound structurally related to obatoclax that has better antitumor effects than obatoclax in liver cancer cell lines, downregulating Mcl-1 protein levels, inhibiting STAT3 phosphorylation, inducing apoptosis, and enhancing SHP1 expression and activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1383727-17-0. Pack Sizes: 1 mg. Product ID: HY-120113. | |
| SC209 | SC209, an ADC cytotoxin extracted from patent WO2021247798, is used in synthesis of anti- EGFR antibody-drug conjugate ADC. SC209 is the payload of STRO-002 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1977557-86-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144880. | |
| SC 51089 free base | SC 51089 free base is a selective antagonist of prostaglandin E 2 EP1 receptor , with K i s of 1.3, 11.2, 17.5, and 61.1 μM for EP1 , TP , EP3 , and FP receptors , respectively. SC 51089 free base exhibits neuroprotective activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 146033-03-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108563A. | |
| SC-514 | SC-514 is a selective IKK-2 inhibitor ( IC 50 =11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GK 01140. CAS No. 354812-17-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13802. | |
| SC-560 | SC-560 is a potent and selective COX-1 inhibitor with an IC 50 of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 188817-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-59105. | |
| SC-58125 | SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2) , with an IC 50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162054-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013164. | |
| (S)-(+)-Carvone | (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes ( SOD , CAT ) and ROS , reduces the levels of oxidative stress markers ( MDA , AChE ), reduces the secretion of proinflammatory cytokines ( IL-1β , IL-4 , IL-6 , IL-10 ), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase -8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12]. Uses: Scientific research. Group: Natural products. Alternative Names: D-Carvone. CAS No. 2244-16-8. Pack Sizes: 500 mg; 1 g. Product ID: HY-W013579. | |
| SCH-202676 hydrobromide | SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors ( GPCRs ) and adenosine receptor ( AR ). SCH-202676 hydrobromide has antiviral activity and inhibits 3CL pro in a time-dependent manner with an IC 50 value of 0.655 μM [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 265980-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110012. | |
| SCH 221510 | SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC 50 of 12 nM and K i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 322473-89-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107722. | |
| SCH-23390 hydrochloride | SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D 1 -like receptor antagonist with K i s of 0.2 nM and 0.3 nM for the D 1 and D 5 receptor , respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT 2C receptor agonist with a K i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT 2 and 5-HT 1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC 50 of 268 nM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-(+)-SCH-23390 hydrochloride. CAS No. 125941-87-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19545A. | |
| SCH 50911 | SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC 50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3 H overflow with an IC 50 of 3 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733717-87-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12783A. | |
| SCH 58261 | SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC 50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 160098-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19533. | |
| SCH79797 | SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC 50 of 70 nM and a K i of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC 50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 245520-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14993. | |
| SCH79797 dihydrochloride | SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC 50 of 70 nM and a K i of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC 50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216720-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14994. | |
| SCH-900271 | SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC 50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 915210-50-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111143. | |
| Schisandrin | Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Schizandrin; Schizandrol; Schizandrol-A. CAS No. 7432-28-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0691. | |
| Schisandrin A | Schisandrin A inhibits CYP3A activity with an IC 50 of 6.60 μM and K i of 5.83 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Schizandrin-A; Wuweizisu-A; Deoxyschizandrin. CAS No. 61281-38-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0693. | |
| (+)-Schisandrin B | (+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis , has antioxidant effect on rodent liver and heart [1]. Uses: Scientific research. Group: Natural products. CAS No. 82467-52-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2267. | |
| Schisandrin B | Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents. Uses: Scientific research. Group: Natural products. Alternative Names: γ-Schisandrin; Wuweizisu B. CAS No. 61281-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0089. | |
| Schisandrone | Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera [1]. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia [2]. Uses: Scientific research. Group: Natural products. CAS No. 98619-25-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2245. | |
| Schisantherin A | Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation. Uses: Scientific research. Group: Natural products. Alternative Names: Gomisin-C; Schizantherin-A; Wuweizi ester-A. CAS No. 58546-56-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0694. | |
| Sclareol | Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis [1]. Uses: Scientific research. Group: Natural products. CAS No. 515-03-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0128. | |
| Sclareolide | Sclareolide is isolated from the flower of Perilla frutescens with antibacterial and cytotoxic activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 564-20-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0129. | |
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