MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| NSP-805 | NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3) , and a cardiotonic agent with vasodilator properties. Uses: Scientific research. Group: Signaling pathways. CAS No. 125068-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-19102. |  |
| NST-628 | NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3002056-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-158115. | |
| N-Stearoylglycine | N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Stearoylglycine; N-Octadecanoylglycine. CAS No. 6333-54-6. Pack Sizes: 250 mg. Product ID: HY-W141932. | |
| N-Stearoyl Taurine | Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Uses: Scientific research. Group: Signaling pathways. CAS No. 63155-80-6. Pack Sizes: 1 mg (2.55 mM * 1 mL in Methanol). Product ID: HY-120964. | |
| N-Succinimidyl-S-acetylthioacetate | N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: SATA. CAS No. 76931-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135233. | |
| NT-0796 | NT-0796 is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. NT-0796 inhibits IL-1β release in human PBMC cells with an IC 50 value of 0.32 nM. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 reverses high fat diet-induced obesity, systemic inflammation and astrogliosis in the diet-induced obesity mouse model. NT-0796 is promising for research of neurodegenerative disorders, including Alzheimers disease, Parkinsons disease, multiple sclerosis, and amyotrophic lateral sclerosis [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2272917-13-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156438. | |
| NT157 | NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tyrphostin NT157. CAS No. 1384426-12-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100037. | |
| NT219 | NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 ( IRS1/2 ) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1198078-60-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145935. | |
| N-tert-Boc-cis-4-fluoro-L-proline | N-tert-Boc-cis-4-fluoro-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Peptides. CAS No. 203866-13-1. Pack Sizes: 5 g. Product ID: HY-W003222. | |
| N-tert-Butyl-α-phenylnitrone | N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3376-24-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-128463. | |
| N-Tetradecanoyl-L-homoserine lactone | N-Tetradecanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202284-87-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133684. | |
| NTNCB hydrochloride | NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a K i of 8 nM against human Y5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191931-56-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107733. | |
| NTPAN-MI | NTPAN-MI is a fluorescent probe. NTPAN-MI is selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on the extent of proteostasis[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2411398-95-1. Pack Sizes: 1 mg. Product ID: HY-D1781. | |
| N-trans-Caffeoyltyramine | N-TRANS-CaffeoyLtyramine is an effective inflammatory response regulator, which has antioxidant activity and anticoagulation effects [1]. Uses: Scientific research. Group: Natural products. CAS No. 103188-48-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N8241. | |
| N-trans-Feruloyltyramine | N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H 2 O 2 -induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: N-feruloyltyramine; Moupinamide. CAS No. 66648-43-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2410. | |
| NTRC-824 | NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC 50 of 38 nM and a K i of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (K i >30 μM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1623002-61-8. Pack Sizes: 1 mg. Product ID: HY-12436. | |
| NU6102 | NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 ?M), DYRK1A (IC50 of 0.9 ?M), PDK1 (IC50 of 0.8 ?M) and ROCKII (IC50 of 0.6 ?M)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 444722-95-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15569. | |
| NU 7026 | NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 ?M, also inhibits PI3K with IC50 of 13 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY293646. CAS No. 154447-35-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15719. | |
| NU9056 | NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450644-28-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110127. | |
| NUC-7738 | NUC-7738, an aryloxy phosphoramidate of 3-Deoxyadenosine, is a 5-aryloxy phosphoramidate prodrug of 3-Deoxyadenosine (3-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2348493-39-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136506. | |
| Nuciferine | Nuciferine is an antagonist at 5-HT 2A ( IC 50 =478 nM), 5-HT 2C ( IC 50 =131 nM), and 5-HT 2B ( IC 50 =1 μM), an inverse agonist at 5-HT 7 ( IC 50 =150 nM), a partial agonist at D 2 ( EC 50 =64 nM), D 5 ( EC 50 =2.6 μM) and 5-HT 6 ( EC 50 =700 nM), an agonist at 5-HT 1A ( EC 50 =3.2 μM) and D 4 ( EC 50 =2 μM) receptor. Uses: Scientific research. Group: Natural products. CAS No. 475-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N0049. | |
| Nuclear Fast Red | Nuclear Fast Red, an anthraquinone dye, is commonly used in conjunction with an excess of aluminum ions as a red nuclear counterstain. Nuclear fast red has been used as a histochemical and colorimetric reagent for calcium [1]. Nuclear fast red as highly sensitive "off/on" fluorescent probe for detecting guanine [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Kernechtrot. CAS No. 6409-77-4. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-D0943. | |
| Nuclease P1 | Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries [1]. Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc. Uses: Scientific research. Group: Signaling pathways. CAS No. 54576-84-0. Pack Sizes: 250 U. Product ID: HY-P2963. | |
| Nuclease S1, Aspergillus oryzae | Nuclease S1, Aspergillus oryzae is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37288-25-8. Pack Sizes: 10 KU. Product ID: HY-P2773. | |
| Nuclease, Serratia marcescens | Serratia marcescens nuclease (EC 3.1.30.2) is a nonspecific nuclease. Serratia marcescens nuclease has broad utility due to its potent digestive activity toward both DNA and RNA [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Serratia marcescens nuclease. CAS No. 9025-65-4. Pack Sizes: 5 KU; 10 KU; 25 KU. Product ID: HY-131160. | |
| Nucleoprotein (396-404) | Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: NP 396. CAS No. 158475-79-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1571. | |
| Nudifloramide | Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2PY. CAS No. 701-44-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113432. | |
| Numidargistat | Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB-1158; INCB01158. CAS No. 2095732-06-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-101979. | |
| Numidargistat dihydrochloride | Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB-1158 dihydrochloride; INCB01158 dihydrochloride. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101979A. | |
| Nurr1 agonist 4 | Nurr1 agonist 4 (compound 8) is a high-affinity Nurr1 agonist with EC 50 of 2.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 87645-58-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-149867. | |
| Nurr1 agonist 7 | Nurr1 agonist 7 (compound 110) is a Nurr1 agonist with an EC 50 value of 0.12 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 228707-95-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-157026. | |
| Nurr1 inverse agonist-1 | Nurr1 inverse agonist-1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1. Uses: Scientific research. Group: Signaling pathways. CAS No. 2758673-07-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132909. | |
| Nurulimab | Nurulimab (BCD-145) is an anti- cytotoxic T lymphocyte antigen-4 (anti-CTLA-4) human monoclonal antibody. Nurulimab can be can be used in research of melanoma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BCD-145. CAS No. 2168561-20-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99760. | |
| Nusinersen | Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258984-36-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-112980. | |
| Nusinersen sodium | Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen sodium improves spinal muscular atrophy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112980A. | |
| Nutlin-3 | Nutlin-3 is a commercial available p53-MDM2 inhibitor, with K i of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 548472-68-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50696. | |
| Nutlin-3a | Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor ( IC 50 =90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Rebemadlin. CAS No. 675576-98-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10029. | |
| NV03 | NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a K d of 2.4 μM. NV03 has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2448341-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125292. | |
| NV-5138 | NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095886-80-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114384. | |
| NV-5138 hydrochloride | NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2639392-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-114384B. | |
| N-Vanillyldecanamide | N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum , significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner [1]. Uses: Scientific research. Group: Natural products. CAS No. 31078-36-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5099. | |
| NVP-2 | NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 ?M, 0.706 ?M, and 0.605 ?M, respectively. NVP-2 induces cell apoptosis.[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1263373-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12214A. | |
| NVP 231 | NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK[1]. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 362003-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13945. | |
| NVP-AEW541 | NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 ?M. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 ?M. NVP-AEW541 has antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AEW541. CAS No. 475489-16-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50866. | |
| NVP-BHG712 | NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BHG712. CAS No. 940310-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13258A. | |
| NVP-BHG712 isomer | NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245892-85-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13258. | |
| NVP-BSK805 dihydrochloride | NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1942919-79-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14722A. | |
| NVP-CGM097 | NVP-CGM097 is a potent and selective MDM2 inhibitor with IC 50 of 1.7±0.1 nM for hMDM2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGM097. CAS No. 1313363-54-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15954. | |
| NVP-CGM097 sulfate | NVP-CGM097 sulfate is a potent and selective MDM2 inhibitor with IC 50 of 1.7±0.1 nM for hMDM2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGM097 sulfate. CAS No. 1313367-56-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15954B. | |
| NVP-DFF332 | HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC 50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HIF-2α-IN-8. CAS No. 2734922-78-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148860. | |
| NVP-DFV890 | NVP-DFV890 (Comopound 102) is a NLRP3 antagonist. NVP-DFV890 can be used for osteoarthritis research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3 antagonist 2. CAS No. 2271394-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155876. | |
| NVP-DKY709 | NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2291360-73-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-144998. | |
| NVP-HSP990 | NVP-HSP990 is a potent, selective and orally active Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90?, Hsp90?, and Grp94, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HSP-990. CAS No. 934343-74-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15190. | |
| NVP-TAE 226 | NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAE226. CAS No. 761437-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13203. | |
| NVP-TAE 684 | NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAE 684. CAS No. 761439-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10192. | |
| NVP-TNKS656 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC 50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNKS656. CAS No. 1419949-20-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13990. | |
| NVS-CECR2-1 | NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 ( CECR2 ) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity ( IC 50 =47 nM; K D =80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1992047-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110374. | |
| NVS-PAK1-1 | NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC 50 of 5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1783816-74-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100519. | |
| NVS-PAK1-C | NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC 50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 ( IC 50 =270 nM) and phosphorylated PAK2 ( IC 50 =720 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250019-95-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131043. | |
| NX-1607 | NX-1607 (Compound 23) is an inhibitor of Cbl-b , an E3 enzyme in the ubiquitin-proteasome pathway, with an IC 50 value of less than 1 nM. NX-1607 can be used in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cbl-b-IN-3. CAS No. 2573775-59-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141432. | |
| NX-2127 | NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] [2]. NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304). Uses: Scientific research. Group: Signaling pathways. CAS No. 2416131-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153220. | |
| NX-5948 | NX-5948 (BTK-IN-24) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. NX-5948 exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. NX-5948 is efficacious in a mouse collageninduced arthritis (CIA) model. NX-5948 can cross the blood brain barrier (BBB). NX-5948 is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: ligand for target protein; Blue: CRBN; Black: linker) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTK-IN-24. CAS No. 2649400-34-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-153321. | |
| NXE0041178 | NXE0041178 (Procedure 1) is a GPR52 receptor modulator with the potential to study neuropsychiatric diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2642079-89-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154980. | |
| NXP800 | NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCT361814. CAS No. 1693734-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145927. | |
| NXT629 | NXT629 is a potent, selective, and competitive PPAR-? antagonist, with an IC50 of 77 nM for human PPAR?, shows high selectivity over other nuclear hormone receptor, such as PPAR?, PPAR?, ER?, GR and TR?, IC50s are 6.0, 15, 15.2, 32.5 and >100 ?M, respectively[1]. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454925-59-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114263. | |
| Nybomycin | Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 30408-30-1. Pack Sizes: 500 μg. Product ID: HY-123635. | |
| NY-ESO-1 (157-165) peptide | NY-ESO-1 (157-165) peptide is a peptide fragment from NY-ESO-1 protein. NY-ESO-1 (157-165) peptide can activate the immune system, especially for HLA-A2 positive individuals, it can be recognized by CD8+ T cells, thus triggering an immune response. NY-ESO-1 (157-165) peptide is expressed in a variety of tumors and can be used as a target for tumor immunotherapy [1]. Uses: Scientific research. Group: Peptides. CAS No. 202815-17-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10493. | |
| Nylidrin hydrochloride | Nylidrin hydrochloride is an inhibitor of IgE-mediated histamine release in passive sensitized rat peritoneal mast cells, and it has anti-allergic effects. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Buphenine hydrochloride. CAS No. 849-55-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B1404. | |
| Nystatin | Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion [1] [2]. Nystatin is a cholesterol-sequestering agent [3] , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis [5]. Uses: Scientific research. Group: Natural products. CAS No. 1400-61-9. Pack Sizes: 500 mg. Product ID: HY-17409. | |
| Nystose | Nystose is a tetrasaccharide with two fructose molecules linked via beta (1?2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the Wnt/?-catenin signaling pathway[2]. Uses: Scientific research. Group: Natural products. CAS No. 13133-07-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1499. | |
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