MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Propargyl-PEG7-alcohol | Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs [1]. Propargyl-PEG7-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1422023-54-8. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-130378. |  |
| Propiconazole | Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 60207-90-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-B0847. | |
| Propidium Iodide | Propidium Iodide (PI) is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis ( apoptosis ) or necrosis ( necrosis ), and is often used in flow cytometry analysis. Uses: Scientific research. Group: Fluorescent dye. CAS No. 25535-16-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-D0815. | |
| Propidium monoazide | Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR [1]. Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 91416-20-5. Pack Sizes: 1 mg. Product ID: HY-D1444. | |
| Propiolactone | Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: β-propiolactone; 2-Oxetanone; Betaprone. CAS No. 57-57-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-107931. | |
| Propionyl coenzyme A lithium | Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 108321-21-7. Pack Sizes: 1 mg. Product ID: HY-134424. | |
| Propionyl-DL-carnitine chloride | Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 18828-58-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101018. | |
| Propionylglycine | Propionylglycine is a peptide [1]. Uses: Scientific research. Group: Peptides. CAS No. 21709-90-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-W587803. | |
| Propionyl-L-carnitine | Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis , Bax , and reduces NF-κB , VCAM-1 , MCP-1 , and survivin. Propionyl-L-carnitine activates Src kinase , Akt , induces p-AMPK and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis [1] [2] [3] [4] [5] [6] [7] [8] [9] [10]. Uses: Scientific research. Group: Peptides. CAS No. 20064-19-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-121705. | |
| Propionylpromazine | Propionylpromazine is a dopamine receptor DRD2 antagonist. Propionylpromazine also is an effective tranquillizer. Propionylpromazine can be used in veterinary studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3568-24-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-111480. | |
| Propionylpromazine hydrochloride | Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 ( DRD2 ) antagonist, can be used in the research of Parkinson disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Propiopromazine hydrochloride. CAS No. 7681-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-W040146. | |
| Propiverine hydrochloride | Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 54556-98-8. Pack Sizes: 10 mM * 1 mL; 25 mg. Product ID: HY-116408A. | |
| Propofol | Propofol potently and directly activates GABA A receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2,6-Diisopropylphenol. CAS No. 2078-54-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0649. | |
| Propoxur | Propoxur is a carbamate insecticide with a fast knockdown and long residual effect used against turf, forestry, and household pests and fleas. Uses: Scientific research. Group: Signaling pathways. CAS No. 114-26-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0916. | |
| Propoxur (Standard) | Propoxur (Standard) is the analytical standard of Propoxur. This product is intended for research and analytical applications. Uses: Scientific research. Group: Signaling pathways. CAS No. 114-26-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0916R. | |
| Propoxycaine hydrochloride | Propoxycaine hydrochloride inhibits voltage-gated sodium channels , and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation. Uses: Scientific research. Group: Signaling pathways. CAS No. 550-83-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1243. | |
| Propranolol | Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K i values of 1.8 nM and 0.8 nM, respectively [1]. Propranolol inhibits [ 3 H]-DHA binding to rat brain membrane preparation with an IC 50 of 12 nM [2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy [3]. Uses: Scientific research. Group: Natural products. CAS No. 525-66-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0573B. | |
| Propranolol-d7 | Propranolol-d 7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 98897-23-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0573BS. | |
| Propranolol-d7 hydrochloride | Propranolol-d 7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1613439-56-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0573S. | |
| Propranolol-d7 (ring-d7) | Propranolol-d 7 (ring-d 7 ) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 344298-99-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0573S1. | |
| Propranolol hydrochloride | Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K i values of 1.8 nM and 0.8 nM, respectively [1]. Propranolol hydrochloride inhibits [ 3 H]-DHA binding to rat brain membrane preparation with an IC 50 of 12 nM [2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy [3]. Uses: Scientific research. Group: Natural products. CAS No. 318-98-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0573. | |
| Propylboronic acid | Propylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 17745-45-8. Pack Sizes: 25 g; 100 g. Product ID: HY-W007470. | |
| Propylparaben | Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate. CAS No. 94-13-3. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-N2026. | |
| Propylparaben (Standard) | Propylparaben (Standard) is the analytical standard of Propylparaben. This product is intended for research and analytical applications. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 94-13-3. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-N2026R. | |
| Propyl pyrazole triol | Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ER?) agonist. The relative binding affinity of Propyl pyrazole triol for ER? (ER?: 49%) around 410 times higher compared with estrogen receptor beta (ER?: 0.12%)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PPT. CAS No. 263717-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100689. | |
| Propylthiouracil | Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU. CAS No. 51-52-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0346. | |
| Propyphenazone | Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Isopropylantipyrine; Isopropylphenazone. CAS No. 479-92-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-A0273. | |
| Propyzamide | Propyzamide is a anti-microtubule herbicide [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Kerb; RH 315. CAS No. 23950-58-5. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-B1883. | |
| Prosaptide Tx14(A) | Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 196391-82-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1342. | |
| Proscillaridin A | Proscillaridin A is a potent poison of topoisomerase I/II activity with IC 50 values of 30 nM and 100 nM, respectively [1]. Uses: Scientific research. Group: Natural products. CAS No. 466-06-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N2331. | |
| Prostaglandin B2 | Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 13367-85-6. Pack Sizes: 1 mg (29.90 mM * 100 μL in Methyl acetate); 5 mg (29.90 mM * 500 μL in Methyl acetate). Product ID: HY-113042. | |
| Prostaglandin D2 | Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals [1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances [2]. PGD2 plays a protective role by suppressing inflammation [3]. Uses: Scientific research. Group: Natural products. Alternative Names: PGD2. CAS No. 41598-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101988. | |
| Prostaglandin E1 | Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K i s of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3 , EP4 , EP2 , IP and EP1 , respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Alprostadil; PGE1. CAS No. 745-65-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0131. | |
| Prostaglandin E2 | Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Uses: Scientific research. Group: Natural products. Alternative Names: PGE2; Dinoprostone. CAS No. 363-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101952. | |
| Prostaglandin F1a | Prostaglandin F1a is a compound that has the effect of contracting smooth muscle and lowering blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 745-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-113459. | |
| Prostaglandin H2 | Prostaglandin H2 (PGH2), a potent vasoconstrictor, is produced by the conversion of Arachidonic acid (AA). Prostaglandin H2 is asubstrate for the production of Prostaglandins (PGs) and thromboxanes (TXs) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PGH2. CAS No. 42935-17-1. Pack Sizes: 10 μg (283.71 μM * 100 μL in Acetone); 50 μg (283.71 μM * 500 μL in Acetone); 100 μg (283.71 μM * 1 mL in Acetone). Product ID: HY-136500. | |
| Prostaglandin J2 | Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: PGJ2. CAS No. 60203-57-8. Pack Sizes: 500 μg (14.95 mM * 100 μL in Methyl acetate). Product ID: HY-113366. | |
| Prostratin | Prostratin, a natural terpenoid compound, is a PKC activator, with a K i of 12.5 nM and shows inhibitory effect on HIV-1. Uses: Scientific research. Group: Natural products. CAS No. 60857-08-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107421. | |
| PROTAC AR/AR-V7 degrader-1 | PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 ?M for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2841308-96-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162412. | |
| PROTAC AR Degrader-8 | PROTAC AR Degrader-8 (Compound NP18) is the PROTAC degrader for androgen receptor ( AR ), that degrades AR-FL with DC 50 of 0.018 μM and 0.14 μM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC 50 of 0.026 μM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC 50 of 0.038 μM and 1.11 μM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model [1]. (Pink: ligand for target protein AR ligand-33 (HY-170330); Black: linker (HY-W007731); Blue: ligand for E3 ligase Cereblon (HY-14658)). Uses: Scientific research. Group: Signaling pathways. CAS No. 3044108-04-2. Pack Sizes: 1 mg. Product ID: HY-170329. | |
| PROTAC Bcl2 degrader-1 | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 ?M; DC50, 3.0 ?M) and Mcl-1 (IC50, 11.81 ?M) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1] (Blue: CRBN ligand, Black: linker?Pink: Mcl-1/Bcl-2 inhibitor, Nap-1). Uses: Scientific research. Group: Signaling pathways. CAS No. 2378801-85-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125876. | |
| PROTAC B-Raf degrader 1 | PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2364367-27-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111758. | |
| PROTAC BRAF-V600E degrader-1 | PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 (HY-107779), red part; E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part; PROTAC linker: G007-LK (HY-12438), black part. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417296-84-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-137487. | |
| PROTAC BRD4 Degrader-8 | PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026420-38-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-138555. | |
| PROTAC CDK2/9 Degrader-1 | PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408641-24-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130709. | |
| PROTAC ERα Degrader-1 | PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha ( ERα ) degrader. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417369-94-7. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112098. | |
| PROTAC EZH2 Degrader-1 | PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641601-67-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147525. | |
| PROTAC GPX4 degrader-1 | PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 ?M in HT1080 cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2916433-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-149236. | |
| PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033812-84-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155008. | |
| PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 ?M). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2488851-89-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131911. | |
| PROTAC JAK1 degrader 1 | PROTAC JAK1 degrader 1 degrader 1 (compound 10c) is an effective and selective PROTAC JAK1 degrader with a DC50 of 214 nM. PROTAC JAK1 degrader 1 has antitumor activity. (Structure Note: PINK, JAK1 ligand 1 (HY-10961); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3052553-20-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162608. | |
| PROTAC K-Ras Degrader-4 | PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960); Black: linker (HY-159790); Blue: ligand for E3 ligase VHL (HY-W998248)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2938169-99-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-159788. | |
| PROTAC KRAS G12D degrader 1 | PROTAC KRAS G12D degrader 1 (compound 8o) is a potent, rapid, and selective degrader of protac KRASG12D with DC50 of 38.06 nM. PROTAC KRAS G12D degrader 1 showes significant antitumor efficacy[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033583-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-161176. | |
| PROTAC YAP degrader-1 | PROTAC YAP degrader-1 (compound YZ-6) is a PROTAC targeting YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 is composed of PROTAC target protein ligand NSC682769 (HY-168017) (red part) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019) (blue+black part), in which the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058483-58-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168016. | |
| proTAME | proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1362911-19-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124955. | |
| Protamine sulfate | Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9009-65-8. Pack Sizes: 100 mg. Product ID: HY-107911. | |
| Protease-Activated Receptor-1, PAR-1 Agonist | Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 141136-85-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2518. | |
| Protease-Activated Receptor-2, amide | Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. Uses: Scientific research. Group: Peptides. CAS No. 190383-13-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0283. | |
| Protease-Activated Receptor-4 | Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Uses: Scientific research. Group: Peptides. CAS No. 245443-52-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0297. | |
| Protectin D1 | Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3 , ASC , and Caspase-1 , and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Neuroprotectin D1; NPD1. CAS No. 660430-03-5. Pack Sizes: 10 μg (138.7 μM * 200 μL in ethanol). Product ID: HY-130413. | |
| Protegrin-1 | Protegrin-1 is a antimicrobial peptide with antimicrobial activity [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PG1. CAS No. 168831-77-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1633. | |
| Protein A | Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: SPA. CAS No. 308083-69-4. Pack Sizes: 5 mg. Product ID: HY-NP006. | |
| Proteinase, Aspergillus oryzae | Proteinase, Aspergillus oryzae refers to the enzymes with proteolytic activity. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9001-92-7. Pack Sizes: 500 mg; 1 g. Product ID: HY-B2228. | |
| Proteinase K | Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Protease K. CAS No. 39450-01-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-108717. | |
| Protein kinase inhibitor 1 hydrochloride | Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC 50 s of 136 and 74 nM for HIPK1 and HIPK2, and a K d of 9.5 nM for HIPK2. Uses: Scientific research. Group: Signaling pathways. CAS No. 2321337-71-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00439A. | |
| Protein kinase inhibitor 6 | Protein kinase inhibitor 6 is a protein kinase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 348-45-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-47026. | |
| Prothioconazole | Prothioconazole is a triazolinthione fungicide. Prothioconazole is a CYP51 inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JAU-6476. CAS No. 178928-70-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-116568. | |
| Prothionamide | Protionamide (prothionamide) acts on tuberculosis and leprosy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Protionamide. CAS No. 14222-60-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0306. | |
| PROT-IN-1 | PROT-IN-1 (Compound 2) is a proline transporter ( PROT ) inhibitor ( IC 50 : 1.48 μM). PROT-IN-1 can be used for research of cognitive disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329935-45-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153763. | |
| Protirelin | Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. Uses: Scientific research. Group: Peptides. Alternative Names: Thyrotropin-releasing-hormone; TRH. CAS No. 24305-27-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0002. | |
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